MCID: CHN010
MIFTS: 44

Chondroma

Categories: Bone diseases, Cancer diseases, Rare diseases

Aliases & Classifications for Chondroma

MalaCards integrated aliases for Chondroma:

Name: Chondroma 12 75 53 55 44 15 72
Central Chondroma 12
Enchondroma 72

Classifications:



External Ids:

Disease Ontology 12 DOID:2602
MeSH 44 D002812
NCIt 50 C53459
SNOMED-CT 68 31186001
UMLS 72 C0936248 C1704356

Summaries for Chondroma

Disease Ontology : 12 A cell type benign neoplasm that is a cartilaginous tumor encapsulated with a lobular growing pattern.

MalaCards based summary : Chondroma, also known as central chondroma, is related to juxtacortical chondroma and paragangliomas 1, and has symptoms including pain An important gene associated with Chondroma is SDHC (Succinate Dehydrogenase Complex Subunit C), and among its related pathways/superpathways are Carbon metabolism and Pyruvate metabolism and Citric Acid (TCA) cycle. The drugs Dopamine and Methamphetamine have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and tongue, and related phenotypes are homeostasis/metabolism and mortality/aging

Wikipedia : 75 A chondroma is a benign cartilaginous tumor, which is encapsulated with a lobular growing... more...

Related Diseases for Chondroma

Diseases related to Chondroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 203)
# Related Disease Score Top Affiliating Genes
1 juxtacortical chondroma 33.9 HMGA2 CTNNB1
2 paragangliomas 1 31.6 SDHD SDHC SDHB
3 carney triad 31.2 SDHD SDHC SDHB SDHA PDGFRA
4 gastric leiomyosarcoma 30.1 SDHD PDGFRA
5 multiple endocrine neoplasia 29.9 SDHC SDHB
6 paraganglioma 29.8 SDHD SDHC SDHB SDHA
7 pleomorphic adenoma 29.8 HMGA2 ACTC1
8 glomus tumor 29.6 SDHD SDHB ACTC1
9 paraganglioma and gastric stromal sarcoma 29.5 SDHD SDHC SDHB
10 hereditary paraganglioma-pheochromocytoma syndromes 28.8 SDHD SDHC SDHB SDHA
11 gastrointestinal stromal tumor 27.2 SDHD SDHC SDHB SDHA PDGFRA ACTC1
12 extraskeletal chondroma 12.6
13 dysplasia epiphysealis hemimelica with chondromas and osteochondromas 12.3
14 central nervous system chondroma 12.2
15 phalanx chondroma 12.2
16 chondroid chordoma 11.5
17 carpotarsal osteochondromatosis 11.3
18 cartilage cancer 11.2
19 chondrosarcoma 10.8
20 fibromatosis 10.5 CTNNB1 ACTC1
21 leiomyosarcoma 10.5
22 nonsyndromic paraganglioma 10.4
23 congenital heart defects, hamartomas of tongue, and polysyndactyly 10.4
24 osteochondroma 10.4
25 pseudosarcomatous fibromatosis 10.4 CTNNB1 ACTC1
26 meningioma, radiation-induced 10.4
27 meningioma, familial 10.4
28 spinal meningioma 10.4
29 secretory meningioma 10.4
30 lymphoplasmacyte-rich meningioma 10.4
31 enchondroma 10.4
32 nodular medulloblastoma 10.4 GLI1 CTNNB1
33 chordoma 10.4
34 rare tumor 10.4
35 polymorphous low-grade adenocarcinoma 10.3 CTNNB1 ACTC1
36 fibroma 10.3
37 epithelioid leiomyosarcoma 10.3
38 headache 10.3
39 infratentorial cancer 10.3 GLI1 CTNNB1
40 chondroblastoma 10.3
41 synovial chondromatosis 10.3
42 giant cell tumor 10.2
43 adenoma 10.2
44 carpal tunnel syndrome 10.2
45 osteogenic sarcoma 10.2
46 dedifferentiated liposarcoma 10.1 HMGA2 ACTC1
47 seminal vesicle tumor 10.1 SDHB SDHA
48 carcinosarcoma 10.1 CTNNB1 ACTC1
49 familial isolated dilated cardiomyopathy 10.1 SDHA ACTC1
50 smooth muscle tumor 10.1 HMGA2 ACTC1

Graphical network of the top 20 diseases related to Chondroma:



Diseases related to Chondroma

Symptoms & Phenotypes for Chondroma

UMLS symptoms related to Chondroma:


pain

MGI Mouse Phenotypes related to Chondroma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.8 ACTC1 CTNNB1 PDGFRA SDHA SDHB SDHC
2 mortality/aging MP:0010768 9.76 ACTC1 CTNNB1 GLI1 PDGFRA SDHA SDHB
3 neoplasm MP:0002006 9.35 CTNNB1 GLI1 PDGFRA SDHB SDHD
4 normal MP:0002873 9.1 ACTC1 CTNNB1 GLI1 PDGFRA SDHB SDHD

Drugs & Therapeutics for Chondroma

Drugs for Chondroma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
2
Methamphetamine Approved, Illicit Phase 4 537-46-2 10836
3 Sympathomimetics Phase 4
4 Neurotransmitter Agents Phase 4
5 Central Nervous System Stimulants Phase 4
6 Adrenergic Agents Phase 4
7 Dopamine Agents Phase 4
8 Peripheral Nervous System Agents Phase 4
9 Neurotransmitter Uptake Inhibitors Phase 4
10 Dopamine Uptake Inhibitors Phase 4
11 Autonomic Agents Phase 4
12
Cisplatin Approved 15663-27-1 84093 441203 2767
13
Methotrexate Approved 1959-05-2, 59-05-2 126941
14
Doxorubicin Approved, Investigational 23214-92-8 31703
15
Liposomal doxorubicin 31703

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Bioactive Glass Granules as Bone Graft Substitute in Filling Material of Bone Defects Completed NCT01304121 Phase 4
2 A Randomized Phase II, Placebo-controlled, Multicenter Study Evaluating Efficacy and Safety of Regorafenib in Patients With Metastatic Bone Sarcomas Recruiting NCT02389244 Phase 2 Regorafenib;Placebo
3 Low Grade Chondrosarcoma Versus Enchondroma: Challenges in Diagnosis and Management Completed NCT02996747
4 Thulium Contact Laser in the Treatment of Tumorous and Non-tumorous Laryngotracheal Stenosis Completed NCT02587546
5 Establishment of New Molecular Prototyping Based on Proteomics for Predicting Osteosarcoma Chemotherapy Response and Risk of Recurrence Recruiting NCT03932058 Chemotherapy

Search NIH Clinical Center for Chondroma

Cochrane evidence based reviews: chondroma

Genetic Tests for Chondroma

Anatomical Context for Chondroma

MalaCards organs/tissues related to Chondroma:

41
Bone, Lung, Tongue, Breast, Spinal Cord, Thyroid, Trachea

Publications for Chondroma

Articles related to Chondroma:

(show top 50) (show all 2071)
# Title Authors PMID Year
1
Fusion, disruption, and expression of HMGA2 in bone and soft tissue chondromas. 9 38
14614053 2003
2
Chondrosarcoma of the jaw: a retrospective series. 38
31204208 2019
3
18F-FDG PET/CT in the evaluation of cartilaginous bone neoplasms: the added value of tumor grading. 38
31396797 2019
4
The incidence and outcome of chondral tumours as incidental findings on investigation of shoulder pathology. 38
31422474 2019
5
Inactivation of Lkb1 in postnatal chondrocytes leads to epiphyseal growth-plate abnormalities and promotes enchondroma-like formation. 38
31091421 2019
6
Differing characteristics of cartilaginous lesions of the larynx. 38
31338576 2019
7
Metabolic profiling of serum in patients with cartilage tumours using 1 H-NMR spectroscopy: A pilot study. 38
31323132 2019
8
A pragmatic approach to the imaging and follow-up of solitary central cartilage tumours of the proximal humerus and knee. 38
30827492 2019
9
Synovial chondromatosis and soft tissue chondroma: extraosseous cartilaginous tumor defined by FN1 gene rearrangement. 38
31273315 2019
10
[Chondrosarcoma of the hand arising from multiple enchondromas: a case report]. 38
31363795 2019
11
Skull Base Chondrosarcoma Caused by Ollier Disease: A Case Report and Literature Review. 38
30872199 2019
12
Calcified or ossified benign soft tissue lesions that may simulate malignancy. 38
31297550 2019
13
Intraosseous ganglion diagnosed on cytology: A familiar entity in an exotic location. 38
31359500 2019
14
[A painful ring finger following minimal trauma]. 38
31283120 2019
15
Chondroma of the Tongue. 38
30845089 2019
16
Skull Base Enchondroma and Chondrosarcoma in Ollier Disease and Maffucci Syndrome. 38
31233929 2019
17
IDH1 immunohistochemistry reactivity and mosaic IDH1 or IDH2 somatic mutations in pediatric sporadic enchondroma and enchondromatosis. 38
31240473 2019
18
Loss of SDHB protein expression by immunohistochemistry distinguishes pulmonary chondromas from hamartomas. 38
31236950 2019
19
Can 18F-FDG PET/CT diagnose malignant change in benign chondroid tumors? 38
30921251 2019
20
Distribution and evaluation of bone and soft tissue tumors operated in a tertiary care center. 38
30982757 2019
21
How to Diagnose Enchondroma, Bone Infarct, and Chondrosarcoma. 38
29724496 2019
22
Early Basal Cortisol Level as a Predictor of Hypothalamic-Pituitary-Adrenal (HPA) Axis Function After Pituitary Tumor Surgery. 38
31091548 2019
23
Transsphenoidal Removal of Retroclival Chondroma with Pituitary Transposition Manifesting as Repeated Subarachnoid Hemorrhage: A Case Report. 38
30708387 2019
24
One-Step Laryngotracheal Reconstruction With Prefabricated Corticoperiosteal Flap. 38
30391250 2019
25
Fibroma of tendon sheath embedded in carpal bones mimicking carpal enchondroma: A case report. 38
31008967 2019
26
Resection of Cervical Juxtacortical Chondroma and Circumferential Spinal Stabilization for Kyphotic Deformity. 38
31259132 2019
27
Intracellular cholesterol biosynthesis in enchondroma and chondrosarcoma. 38
31039139 2019
28
Juxta-Cortical Chondroma of the Phalanges: Is there a Role for Cone-Beam Computed Tomography in Diagnosis and Local Staging?: Main teaching point: Low-dose cone-beam computed tomography (CT) may be of additional value to radiographs and magnetic resonance imaging (MRI) in preoperative characterization and local staging of juxta-cortical chondroma. 38
30972379 2019
29
Non-squamous cell carcinoma diseases of the larynx: clinical and imaging findings. 38
30956151 2019
30
High resolution MRI of nail tumors and tumor-like conditions. 38
30777226 2019
31
Chondroma of laryngeal cartilage mimicking thyroid tumor: A case report. 38
30921219 2019
32
An Intraventricular Type of Chondroma : A Case Report. 38
30984997 2019
33
CT-guided percutaneous cryoablation of an osteoid osteoma of the rib☆. 38
30627298 2019
34
Outcome of conservative and surgical treatment of enchondromas and atypical cartilaginous tumors of the long bones: retrospective analysis of 228 patients. 38
30922289 2019
35
Giant cell tumour of the middle phalanx of the middle finger. 38
30914416 2019
36
Intraosseous synovial sarcoma of the distal ulna: a case report and review of the literature. 38
30709383 2019
37
Bullough's Lesion: An Unexpected Diagnosis After the Resection of a Slowly Growing Osseous-Like Retroauricular Bump-Case Report and Review of the Literature. 38
30448575 2019
38
Roles for HB-EGF in Mesenchymal Stromal Cell Proliferation and Differentiation During Skeletal Growth. 38
30550637 2019
39
Coexistence of giant cell tumor of tendon sheath and enchondroma in the middle phalanx of the little finger mimicking a malignant tumor: A case report. 38
30675262 2019
40
Chondroid Tumors as Incidental Findings and Differential Diagnosis between Enchondromas and Low-grade Chondrosarcomas. 38
30699449 2019
41
Intracranial Dural Parafalcine Chondroma: Case Report and Systematic Review of the Literature. 38
30273721 2019
42
Unique and overlapping GLI1 and GLI2 transcriptional targets in neoplastic chondrocytes. 38
30695055 2019
43
Radiographic Enchondroma Surveillance: Assessing Clinical Outcomes and Costs Effectiveness. 38
31413693 2019
44
An Unusual Cervical Mass in the Hyoid Bone: Intermediate-Grade Chondrosarcoma. 38
30944747 2019
45
Rare case of bladder chondroma causing lower urinary tract symptoms. 38
30661043 2019
46
Extra bone chondroma of the shoulder: a case study and literature review. 38
31223366 2019
47
A Rare Case of Acute-Onset Spastic Quadriparesis Caused by a Chondroma of the Cervical Spine. 38
31263610 2019
48
A Large Extraskeletal Chondroma: An Unusual Location in the Lower Extremity, Huge Extraskeletal Chondroma: An Unusual Localization in the Leg. 38
31245325 2019
49
Enchondroma of Tibia as Potential False-positive Finding on 68Ga-DOTATOC PET/CT Scan. 38
30371598 2019
50
Parotid gland chondroma masquerading as pleomorphic adenoma in fine needle aspiration cytology: A diagnostic challenge. 38
30144346 2018

Variations for Chondroma

Expression for Chondroma

Search GEO for disease gene expression data for Chondroma.

Pathways for Chondroma

GO Terms for Chondroma

Cellular components related to Chondroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrial inner membrane GO:0005743 9.46 SDHD SDHC SDHB SDHA
2 protein-DNA complex GO:0032993 9.26 HMGA2 CTNNB1
3 respiratory chain complex II GO:0045273 8.96 SDHC SDHB
4 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) GO:0005749 8.92 SDHD SDHC SDHB SDHA

Biological processes related to Chondroma according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.83 SDHD SDHC SDHB SDHA
2 negative regulation of apoptotic process GO:0043066 9.65 HMGA2 CTNNB1 ACTC1
3 odontogenesis of dentin-containing tooth GO:0042475 9.56 PDGFRA CTNNB1
4 dorsal/ventral pattern formation GO:0009953 9.55 GLI1 CTNNB1
5 epithelial to mesenchymal transition GO:0001837 9.54 HMGA2 CTNNB1
6 aerobic respiration GO:0009060 9.51 SDHC SDHB
7 proximal/distal pattern formation GO:0009954 9.49 GLI1 CTNNB1
8 male genitalia development GO:0030539 9.46 PDGFRA CTNNB1
9 cardiac myofibril assembly GO:0055003 9.43 PDGFRA ACTC1
10 electron transport chain GO:0022900 9.43 SDHC SDHB SDHA
11 respiratory electron transport chain GO:0022904 9.4 SDHB SDHA
12 regulation of osteoblast differentiation GO:0045667 9.37 GLI1 CTNNB1
13 lung development GO:0030324 9.33 PDGFRA GLI1 CTNNB1
14 succinate metabolic process GO:0006105 9.32 SDHB SDHA
15 mitochondrial electron transport, succinate to ubiquinone GO:0006121 9.13 SDHD SDHC SDHA
16 tricarboxylic acid cycle GO:0006099 8.92 SDHD SDHC SDHB SDHA

Molecular functions related to Chondroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 electron transfer activity GO:0009055 9.46 SDHD SDHC SDHB SDHA
2 SMAD binding GO:0046332 9.37 HMGA2 CTNNB1
3 oxidoreductase activity, acting on the CH-CH group of donors GO:0016627 9.32 SDHC SDHA
4 succinate dehydrogenase activity GO:0000104 9.26 SDHD SDHA
5 ubiquinone binding GO:0048039 8.96 SDHD SDHB
6 succinate dehydrogenase (ubiquinone) activity GO:0008177 8.92 SDHD SDHC SDHB SDHA

Sources for Chondroma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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