Aliases & Classifications for Chondromalacia

MalaCards integrated aliases for Chondromalacia:

Name: Chondromalacia 12 77 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:2557
ICD9CM 36 733.92
MeSH 45 D002357
SNOMED-CT 69 63198006
ICD10 34 M94.2 M94.20
UMLS 74 C0085700

Summaries for Chondromalacia

MalaCards based summary : Chondromalacia is related to patella, chondromalacia of and relapsing polychondritis. An important gene associated with Chondromalacia is COMP (Cartilage Oligomeric Matrix Protein), and among its related pathways/superpathways are NF-kappaB Signaling and TNF signaling (REACTOME). The drugs Hyaluronic acid and Methylene blue have been mentioned in the context of this disorder. Affiliated tissues include bone, trachea and testes, and related phenotypes are homeostasis/metabolism and immune system

Wikipedia : 77 Chondromalacia patellae (also known as CMP) is an inflammation of the underside of the patella and... more...

Related Diseases for Chondromalacia

Diseases related to Chondromalacia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 125)
# Related Disease Score Top Affiliating Genes
1 patella, chondromalacia of 34.2 COMP GSTO1 IBSP
2 relapsing polychondritis 32.5 COMP CRP
3 joint disorders 29.8 IL1RN TNF
4 arthritis 29.7 IL1RN TNF TNFRSF1B
5 arthropathy 29.6 COMP CRP TNF
6 osteoarthritis 10.4
7 tendinitis 10.2 COMP CRP
8 cryopyrin-associated periodic syndrome 10.1 CRP IL1RN
9 acute cholangitis 10.1 CRP IL1RN
10 hyper-igd syndrome 10.1 CRP IL1RN
11 schnitzler syndrome 10.1 CRP IL1RN
12 pericardium disease 10.1 CRP IL1RN
13 orbital cellulitis 10.1 CRP IL1RN
14 acute orbital inflammation 10.1 CRP IL1RN
15 pericoronitis 10.1 CRP TNFRSF1B
16 anterior scleritis 10.1 IL1RN TNFRSF1B
17 posterior scleritis 10.0 TNF TNFRSF10A
18 frasier syndrome 10.0
19 tracheoesophageal fistula with or without esophageal atresia 10.0
20 aging 10.0
21 blood group, gerbich system 10.0
22 esophageal atresia 10.0
23 frozen shoulder 10.0
24 patellofemoral pain syndrome 10.0
25 enthesopathy 10.0
26 bursitis 10.0
27 tracheal stenosis 10.0
28 hypermobile ehlers-danlos syndrome 10.0
29 acute mountain sickness 10.0
30 tracheoesophageal fistula 10.0
31 drug reaction with eosinophilia and systemic symptoms 10.0 CRP TNF
32 salpingitis 10.0 CRP TNF
33 vulvar vestibulitis syndrome 10.0 IL1RN TNF
34 transient arthritis 10.0 COMP TNFRSF10A TNFRSF1B
35 relapsing fever 10.0 CRP TNF
36 osteosclerotic myeloma 10.0 IL1RN TNF
37 louse-borne relapsing fever 9.9 CRP TNF
38 streptococcal meningitis 9.9 CRP TNF
39 tuberculous peritonitis 9.9 CRP TNF
40 ischemic heart disease 9.9 CRP TNF
41 diverticulitis 9.9 CRP TNF
42 mycoplasma pneumoniae pneumonia 9.9 CRP TNF
43 hypersensitivity reaction type iii disease 9.9 CRP TNF
44 aseptic meningitis 9.9 IL1RN TNF
45 scrub typhus 9.9 CRP TNF
46 proctitis 9.9 CRP TNF
47 apnea, obstructive sleep 9.9 CRP TNF
48 bacterial sepsis 9.9 CRP TNF
49 suppurative cholangitis 9.9 CRP TNF
50 perinatal necrotizing enterocolitis 9.9 CRP TNF

Graphical network of the top 20 diseases related to Chondromalacia:



Diseases related to Chondromalacia

Symptoms & Phenotypes for Chondromalacia

MGI Mouse Phenotypes related to Chondromalacia:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.5 COMP CRP GSTO1 IL1RN TNF TNFRSF10A
2 immune system MP:0005387 9.17 COMP CRP IBSP IL1RN TNF TNFRSF10A

Drugs & Therapeutics for Chondromalacia

Drugs for Chondromalacia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hyaluronic acid Approved, Vet_approved Phase 4,Not Applicable 9004-61-9 53477741
2
Methylene blue Approved, Investigational Phase 4 61-73-4
3 Pharmaceutical Solutions Phase 4,Not Applicable
4
Povidone-iodine Approved Not Applicable 25655-41-8
5
Lidocaine Approved, Vet_approved Not Applicable 137-58-6 3676
6 Hylan Not Applicable
7 Immunologic Factors Not Applicable
8 Protective Agents Not Applicable
9 Adjuvants, Immunologic Not Applicable
10 Viscosupplements Not Applicable
11
s 1 (combination) Not Applicable
12 neurokinin A Not Applicable
13
Substance P Not Applicable 33507-63-0 44359816

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Efficacy of Intra-articular Collagen Injection in Patients With Knee Joint Pain Compared to Normal Saline Injection Unknown status NCT02539095 Phase 4
2 Injection Site Diversity Influences HA Distribution and Clinical Results in CP and KOA Completed NCT03600571 Phase 4
3 Prevalence of Chondromalacia Patella Among Adolescent Dancers - Correlation Between Symptoms and Sonography Findings Unknown status NCT02606942
4 Randomized Evaluation of the Efficacy of Synvisc-One® for the Treatment of Patellofemoral Chondromalacia Unknown status NCT01771952 Not Applicable
5 Periacetabular Osteotomy With Versus Without Adjunctive Hip Arthroscopy Unknown status NCT02790749 Not Applicable
6 Effect of Pulsed Signal Therapy in Patella Chondromalacia Completed NCT02012413 Not Applicable
7 The ChAMP (Chondral Lesions And Meniscus Procedures) Trial Completed NCT01527201 Not Applicable
8 Changes in Quadriceps Function Following Local or Distant Interventions in Individuals With Patellofemoral Pain Completed NCT01434966 Not Applicable
9 Study of Platelet-rich Plasma in Treating Patients With Tibiofemoral Cartilage Degeneration Completed NCT01418755 Not Applicable
10 Neuroprolotherapy With Physical Therapy for Treatment of Patellar Chondromalacia Not yet recruiting NCT03515720 Not Applicable
11 Subchondral Perfusion Mapping Using Indocyanin Green Laser Terminated NCT02918383 Not Applicable

Search NIH Clinical Center for Chondromalacia

Genetic Tests for Chondromalacia

Anatomical Context for Chondromalacia

MalaCards organs/tissues related to Chondromalacia:

42
Bone, Trachea, Testes, Skin, Heart, Lymph Node, Pancreas

Publications for Chondromalacia

Articles related to Chondromalacia:

(show top 50) (show all 271)
# Title Authors Year
1
Diabetic hip arthropathy is associated with a higher prevalence of femoral head chondromalacia: a case-controlled study. ( 30465436 )
2018
2
Does the grading of chondromalacia patellae influence anterior knee pain following total knee arthroplasty without patellar resurfacing? ( 28986675 )
2018
3
Chondromalacia as pathological finding in arthroscopy of the temporomandibular joint: A retrospective study. ( 29229366 )
2018
4
Investigation of the Relationship between Anterior Knee Pain and Chondromalacia Patellae and Patellofemoral Malalignment. ( 29531488 )
2018
5
The Relationship between Chondromalacia Patella, Medial Meniscal Tear and Medial Periarticular Bursitis in Patients with Osteoarthritis. ( 29333118 )
2017
6
Sagittal plane tilting deformity of the patellofemoral joint: a new concept in patients with chondromalacia patella. ( 27034088 )
2017
7
A new MRI grading system for chondromalacia patellae. ( 27329395 )
2017
8
Association between trochlear morphology and chondromalacia patella: an MRI study. ( 27723501 )
2017
9
The relation between chondromalacia patella and meniscal tear and the sulcus angle/ trochlear depth ratio as a powerful predictor. ( 27911285 )
2017
10
Preoperative Patellofemoral Chondromalacia is Not a Contraindication for Fixed-Bearing Medial Unicompartmental Knee Arthroplasty. ( 28254376 )
2017
11
Magnetic Resonance Imaging for Patellofemoral Chondromalacia: Is There a Role for T2 Mapping? ( 29204454 )
2017
12
Joint Motion Quality in Chondromalacia Progression Assessed by Vibroacoustic Signal Analysis. ( 27060646 )
2016
13
Cyclists Have Greater Chondromalacia Index Than Age-Matched Controls at the Time of Hip Arthroscopy. ( 27289277 )
2016
14
Clinical effect of traditional Chinese spinal orthopedic manipulation in treatment of chondromalacia patellae. ( 29949332 )
2016
15
Outcomes of prolotherapy in chondromalacia patella patients: improvements in pain level and function. ( 24596471 )
2014
16
The association of patellofemoral joint morphology with chondromalacia patella: a quantitative MRI analysis. ( 24651059 )
2014
17
T2 mapping in patellar chondromalacia. ( 24713490 )
2014
18
Cystic chondromalacia of the auricle treated with dual-plane excision with intracartilaginous dissection. ( 25255358 )
2014
19
Correlation between subcutaneous knee fat thickness and chondromalacia patellae on magnetic resonance imaging of the knee. ( 22884229 )
2013
20
Prevalence and clinical significance of chondromalacia isolated to the anterior margin of the lateral femoral condyle as a component of patellofemoral disease: observations at MR imaging. ( 23689689 )
2013
21
A novel biological approach to treat chondromalacia patellae. ( 23700485 )
2013
22
3-D printouts of the tracheobronchial tree generated from CT images as an aid to management in a case of tracheobronchial chondromalacia caused by relapsing polychondritis. ( 24421951 )
2013
23
Does posteromedial chondromalacia reduce rate of return to play after ulnar collateral ligament reconstruction? ( 22009711 )
2012
24
The role of autologous chondrocyte implantation in the treatment of symptomatic chondromalacia patellae. ( 22246591 )
2012
25
The modified tibial tubercle osteotomy for anterior knee pain due to chondromalacia patellae in adults: A five-year prospective study. ( 23610687 )
2012
26
Evaluation of the chondromalacia patella using a microscopy coil: comparison of the two-dimensional fast spin echo techniques and the three-dimensional fast field echo techniques. ( 21228943 )
2011
27
Anterior knee pain: the pitfalls of plica and chondromalacia patellae. ( 21699003 )
2011
28
Bone density in patients with chondromalacia patella. ( 19771434 )
2010
29
Reliability of clinical findings and magnetic resonance imaging for the diagnosis of chondromalacia patellae. ( 20360517 )
2010
30
Capsulolabral advancement for the treatment of glenoid chondromalacia. ( 20608600 )
2010
31
Ulnohumeral chondral and ligamentous overload: biomechanical correlation for posteromedial chondromalacia of the elbow in throwing athletes. ( 20829418 )
2010
32
Open versus closed kinetic chain exercises for patellar chondromalacia in young women. ( 19124993 )
2009
33
Chondromalacia patellae treated by warming needle and rehabilitation training. ( 19663091 )
2009
34
Open versus closed kinetic chain exercises for patellar chondromalacia. ( 17615174 )
2008
35
The diagnostic value of the Clarke sign in assessing chondromalacia patella. ( 18345345 )
2008
36
Idiopathic tracheal stenosis: a clinicopathologic study of 63 cases and comparison of the pathology with chondromalacia. ( 18545144 )
2008
37
Evaluation of magnetic resonance signal modification induced by hyaluronic acid therapy in chondromalacia patellae: a preliminary study. ( 19036227 )
2008
38
MRI quantitative morphologic analysis of patellofemoral region: lack of correlation with chondromalacia patellae at surgery. ( 17954655 )
2007
39
Arthroscopic debridement for grade III and IV chondromalacia of the knee in patients older than 60 years. ( 17993066 )
2007
40
Chondromalacia of trochlear notch after healing of olecranon stress fracture: a case report. ( 16237533 )
2006
41
Retropatellar chondromalacia associated with medial osteoarthritis after meniscus injury. One year of observations in sheep. ( 16699283 )
2006
42
Lunate chondromalacia: evaluation of routine MRI sequences. ( 15855097 )
2005
43
Acetabular labral tears with underlying chondromalacia: a possible association with high-level running. ( 15891725 )
2005
44
Chondromalacia of sesamoids in first metatarsophalangeal joint. ( 15294134 )
2004
45
Evaluation of patellar chondromalacia with MR: comparison between T2-weighted FSE SPIR and GE MTC. ( 15343130 )
2004
46
Cystic chondromalacia of the ear. ( 12619465 )
2003
47
Dynamics of muscle strength improvement during isokinetic rehabilitation of athletes with ACL rupture and chondromalacia patellae. ( 12629465 )
2003
48
MR arthrography in chondromalacia patellae diagnosis on a low-field open magnet system. ( 12727059 )
2003
49
A correlative study between prevalence of chondromalacia patellae and sports injury in 4068 students. ( 14642059 )
2003
50
Relation between isokinetic muscle strength and functional capacity in recreational athletes with chondromalacia patellae. ( 14665581 )
2003

Variations for Chondromalacia

Expression for Chondromalacia

Search GEO for disease gene expression data for Chondromalacia.

Pathways for Chondromalacia

GO Terms for Chondromalacia

Cellular components related to Chondromalacia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.35 COMP CRP IBSP IL1RN TNF
2 extracellular region GO:0005576 9.1 COMP CRP IBSP IL1RN TNF TNFRSF1B

Biological processes related to Chondromalacia according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.65 IL1RN TNF TNFRSF1B
2 extracellular matrix organization GO:0030198 9.58 COMP IBSP TNF
3 positive regulation of interleukin-6 production GO:0032755 9.54 IL1RN TNF
4 cellular response to lipopolysaccharide GO:0071222 9.54 IL1RN TNF TNFRSF1B
5 cellular response to growth factor stimulus GO:0071363 9.52 IBSP TNFRSF1B
6 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.51 TNF TNFRSF1B
7 positive regulation of cell adhesion GO:0045785 9.49 IBSP TNF
8 inflammatory response GO:0006954 9.46 CRP IL1RN TNF TNFRSF1B
9 extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 9.43 TNF TNFRSF10A
10 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.32 TNF TNFRSF1B
11 negative regulation of lipid storage GO:0010888 9.26 CRP TNF
12 positive regulation of JUN kinase activity GO:0043507 9.16 TNF
13 extrinsic apoptotic signaling pathway GO:0097191 8.8 TNF TNFRSF10A TNFRSF1B
14 chronic inflammatory response to antigenic stimulus GO:0002439 8.65 TNF

Molecular functions related to Chondromalacia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 8.8 COMP TNF TNFRSF10A

Sources for Chondromalacia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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