Aliases & Classifications for Chondromalacia

MalaCards integrated aliases for Chondromalacia:

Name: Chondromalacia 12 74 15 71 32

Classifications:



External Ids:

Disease Ontology 12 DOID:2557
ICD9CM 34 733.92
MeSH 43 D002357
SNOMED-CT 67 63198006
ICD10 32 M94.2
UMLS 71 C0085700

Summaries for Chondromalacia

MalaCards based summary : Chondromalacia is related to patella, chondromalacia of and relapsing polychondritis. An important gene associated with Chondromalacia is COMP (Cartilage Oligomeric Matrix Protein), and among its related pathways/superpathways are NF-kappaB Signaling and Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions. The drugs Hyaluronic acid and Methylene blue have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and trachea, and related phenotype is immune system.

Wikipedia : 74 Chondromalacia patellae (also known as CMP) is an inflammation of the underside of the patella and... more...

Related Diseases for Chondromalacia

Diseases related to Chondromalacia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 447)
# Related Disease Score Top Affiliating Genes
1 patella, chondromalacia of 34.8 LAX1 COMP
2 relapsing polychondritis 32.3 MATN1 IL6 CRP COMP
3 osteomyelitis 30.0 TNF IL6 IL1RN
4 enthesopathy 29.8 TNFRSF1B TNF MRAP CRP
5 exostosis 29.7 PES1 MRAP ACAN
6 fasciitis 29.7 TNF IL6 IL1RN CRP
7 osteoarthritis 29.5 TNF MATN1 IL6 IL1RN CRP COMP
8 bone disease 29.5 TNF IL6 IBSP COMP ACAN
9 arthropathy 29.2 TNF IL6 IL1RN CRP COMP ACAN
10 bursitis 29.1 TNFRSF1B TNF PES1 MRAP CRP
11 gastroesophageal reflux 29.1 TNF MPO IL6 IL1RN
12 arthritis 28.6 TNFRSF1B TNF IL6 IL1RN CRP COMP
13 synovitis 28.6 TNF PRTN3 MATN1 IL6 IL1RN CRP
14 tendinitis 27.9 TNFRSF1B TNF PRTN3 PES1 MRAP IL6
15 epiphyseal dysplasia, multiple, 5 10.4 MATN1 COMP
16 ethmoid sinusitis 10.4 PRTN3 CRP
17 tolosa-hunt syndrome 10.4 PRTN3 CRP
18 drug reaction with eosinophilia and systemic symptoms 10.4 TNF CRP
19 bicipital tenosynovitis 10.4 PRTN3 CRP
20 ankylosing spondylitis 1 10.4 TNFRSF1B CRP
21 granulomatous angiitis 10.4 PRTN3 CRP
22 systemic onset juvenile idiopathic arthritis 10.4 TNF IL1RN
23 glossopharyngeal nerve disease 10.3 PRTN3 CRP
24 chromophil adenoma of the kidney 10.3 TNFRSF1B TNF
25 vulvar vestibulitis syndrome 10.3 TNF IL1RN
26 hyper-igd syndrome 10.3 IL1RN CRP
27 cholesterol embolism 10.3 PRTN3 CRP
28 hyperglobulinemic purpura 10.3 TNFRSF1B IL1RN
29 skin sarcoidosis 10.3 TNFRSF1B TNF
30 necrobiosis lipoidica 10.3 TNFRSF1B TNF
31 transient arthritis 10.3 TNFRSF10A MRAP
32 louse-borne relapsing fever 10.3 TNF CRP
33 deep keratitis 10.3 PRTN3 MRAP
34 macrophage activation syndrome 10.3 TNFRSF1B TNF
35 achondrogenesis 10.3 MATN1 COMP ACAN
36 hypochondrogenesis 10.3 MATN1 ACAN
37 cold agglutinin disease 10.3 IL6 CRP
38 external pathological resorption 10.2 TNF IL6
39 neuroretinitis 10.2 MRAP CRP
40 prosthetic joint infection 10.2 IL6 CRP
41 disseminated chorioretinitis 10.2 TNFRSF1B MRAP
42 patellofemoral pain syndrome 10.2
43 trochlear dysplasia 10.2
44 scorpion envenomation 10.2 TNF IL6
45 pseudoachondroplasia 10.2 MATN1 COMP ACAN
46 gastrointestinal tuberculosis 10.2 TNF CRP
47 cerebritis 10.2 TNF CRP
48 tuberculous epididymitis 10.2 TNF CRP
49 granuloma annulare 10.2 TNFRSF1B TNF
50 uremic pruritus 10.2 IL6 CRP

Graphical network of the top 20 diseases related to Chondromalacia:



Diseases related to Chondromalacia

Symptoms & Phenotypes for Chondromalacia

MGI Mouse Phenotypes related to Chondromalacia:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.36 COMP CRP IBSP IL1RN IL6 LAX1

Drugs & Therapeutics for Chondromalacia

Drugs for Chondromalacia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741
2
Methylene blue Approved, Investigational Phase 4 61-73-4
3 Pharmaceutical Solutions Phase 4
4
Povidone-iodine Approved 25655-41-8
5
Lidocaine Approved, Vet_approved 137-58-6 3676
6 Adjuvants, Immunologic
7 Immunologic Factors
8 neurokinin A
9
Substance P 33507-63-0 44359816

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Double-blind, Randomized, Post-marketing Surveillance to Evaluate the Efficacy of Intra-articular Collagen Injection in Patients With Knee Joint Pain Compared to Normal Saline Injection Unknown status NCT02539095 Phase 4
2 Injection Site Diversity Influences Sodium Hyaluronate Distribution and Its Clinical Results in Management of Chondromalacia Patellae and Knee Osteoarthritis: A Preliminary, Multi-central, Randomize-controlled Serial Trial Completed NCT03600571 Phase 4
3 Prevalence of Chondromalacia Patella Among Adolescent Dancers - Correlation Between Symptoms and Sonography Findings Unknown status NCT02606942
4 Prospective, Randomized, Double Blind Evaluation of the Efficacy of a Single Dose of Synvisc-One® (6.0 cc) for the Treatment of Patellofemoral Chondromalacia Unknown status NCT01771952
5 Periacetabular Osteotomy With Versus Without Adjunctive Hip Arthroscopy for Intra-Articular Pathology in Hip Dysplasia: a Prospective Randomized Trial Unknown status NCT02790749
6 Platelet-rich Plasma in Patients With Tibiofemoral Cartilage Degeneration Completed NCT01418755
7 Effect of Pulsed Signal Therapy in Patella Chondromalacia. Randomized Prospective Trial. Completed NCT02012413
8 Changes in Quadriceps Function Following Local or Distant Interventions in Individuals With Patellofemoral Pain Completed NCT01434966
9 Effectiveness of Neuroprolotherapy With Home Physical Therapy Against Isolated Physical Therapy for the Treatment of Patellar Chondromalacia Not yet recruiting NCT03515720
10 The Use of Viscosupplementation for the Treatment of Patients With Persistent Non-mechanical Pain Status-post Partial Menisectomy Withdrawn NCT00971074 Hylan G-F 20

Search NIH Clinical Center for Chondromalacia

Genetic Tests for Chondromalacia

Anatomical Context for Chondromalacia

MalaCards organs/tissues related to Chondromalacia:

40
Bone, Testes, Trachea, Bone Marrow, Lung

Publications for Chondromalacia

Articles related to Chondromalacia:

(show top 50) (show all 977)
# Title Authors PMID Year
1
Can Ellipsoid Sign be One of the Earliest Findings of the Medial Femoral Condyle Chondromalacia of Knee Antero Posterior X-Ray? 61
32549968 2020
2
Quantitative Knee Arthrography in a Large Animal Model of Osteoarthritis Using Photon-Counting Detector CT. 61
31985604 2020
3
Correction to: Patella-patellar tendon angle and lateral patella-tilt angle decrease patients with chondromalacia patella. 61
32533224 2020
4
Patella-patellar tendon angle and lateral patella-tilt angle decrease patients with chondromalacia patella. 61
32451620 2020
5
Is Primary Arthroscopic Repair Using the Pulley Technique an Effective Treatment for Partial Proximal ACL Tears? 61
31876551 2020
6
Chondromalacia of the cranial medial femoral condyle; its occurrence and association with clinical outcome in a population of adult horses with stifle lameness. 61
31710379 2020
7
Patient-specific factors are associated with severity of chondrolabral injury in patients with femoroacetabular impingement. 61
32333055 2020
8
Relation of the chondromalatia patellae to proximal tibial anatomical parameters, assessed with MRI. 61
32324164 2020
9
The relationship between early-onset chondromalacia and the position of the patella. 61
31319691 2020
10
Assessment of the relationship between patellar volume and chondromalacia patellae using knee magnetic resonance imaging. 61
32478301 2020
11
Feasibility of using half-dose Gd-BOPTA for delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) at the knee, compared with standard-dose Gd-DTPA. 61
31141254 2020
12
[Biochemical predictors of cartilaginous tissue metabolic disorders for early osteoarthrosis evidence diagnostics.] 61
32163689 2020
13
Prior Knee Arthroscopy Is Associated With Increased Risk of Revision After Total Knee Arthroplasty. 61
31548115 2020
14
Patellar calcar: morphometric analysis by knee magnetic resonance imaging and three-dimensional reconstruction software-assisted. 61
31529166 2019
15
Joint Space Narrowing in Patients with Femoroacetabular Impingement: A Matched Cohort Study of Military versus Civilian Patients. 61
31125070 2019
16
How Can We Define Clinically Important Improvement in Pain Scores After Hip Arthroscopy for Femoroacetabular Impingement Syndrome? Minimum 2-Year Follow-up Study. 61
31603720 2019
17
Patellofemoral Chondromalacia Does Not Influence Radiographic and Clinical Outcomes following High Tibial Osteotomy. 61
31752024 2019
18
Chondromalacia Patella among Military Recruits with Anterior Knee Pain: Prevalence and Association with Patellofemoral Malalignment. 61
31673166 2019
19
Diabetic hip arthropathy is associated with a higher prevalence of femoral head chondromalacia: a case-controlled study. 61
30465436 2019
20
Injury Risk Associated With Sports Specialization and Activity Volume in Youth. 61
31555716 2019
21
Arthroscopic Evaluation of the Subtalar Joint: a Review and Survey of Pathology. 61
31549854 2019
22
Kellgren-Lawrence scoring system underestimates cartilage damage when indicating TKA: preoperative radiograph versus intraoperative photograph. 61
31209613 2019
23
Prevalence and Clinical Implications of Chondral Injuries After Hip Arthroscopic Surgery for Femoroacetabular Impingement Syndrome. 61
31411901 2019
24
An Analysis of Symptomatic Meniscal Re-Tear Incidence in Two Age Populations: Differences in Older versus Younger Adults. 61
31390671 2019
25
Optimizing Patellofemoral Cartilage Restoration and Instability With Tibial Tubercle Osteotomy. 61
31395155 2019
26
Intra-articular Injection of Type I Atelocollagen to Alleviate Knee Pain: A Double-Blind, Randomized Controlled Trial. 61
31370668 2019
27
Correlation of distraction index with arthroscopic findings in juvenile dogs with hip dysplasia. 61
31222781 2019
28
A novel clinical test for assessing patellar cartilage changes and its correlation with magnetic resonance imaging and arthroscopy. 61
29601214 2019
29
[Hyaluronate acid for treatment of chondromalacia patellae: a 52-week follow-up study]. 61
31340911 2019
30
Isolated meniscus extrusion associated with meniscotibial ligament abnormality. 61
31332493 2019
31
Survivorship and Outcome of Hip Arthroscopy for Femoroacetabular Impingement Syndrome Performed With Modern Surgical Techniques. 61
31145663 2019
32
Bilateral Ulnar Styloid Impaction Syndrome Treated with Ulnar Styloidectomy. 61
31192047 2019
33
The relationship between patellofemoral arthritis and fat tissue volume, body mass index and popliteal artery intima-media thickness through 3T knee MRI 61
31121997 2019
34
Prospective, Randomized, Double-Blind Evaluation of the Efficacy of a Single-Dose Hyaluronic Acid for the Treatment of Patellofemoral Chondromalacia. 61
31263727 2019
35
A rare complication of knee hematoma after genicular nerve radiofrequency ablation. 61
31583351 2019
36
A Case of Knee Monoarthritis Caused by Mycobacterium Tuberculosis. 61
30982829 2019
37
WHO/ILO work-related burden of disease and injury: Protocol for systematic reviews of exposure to occupational ergonomic risk factors and of the effect of exposure to occupational ergonomic risk factors on osteoarthritis of hip or knee and selected other musculoskeletal diseases. 61
30583853 2019
38
Is there a correlation between arthroscopic findings and the clinical signs and symptoms of patients with internal derangement of the temporomandibular joint? A prospective study. 61
30049606 2019
39
Contrast-enhanced MRI compared to direct joint visualization at arthroscopy in pediatric patients with suspected temporomandibular joint synovitis. 61
30382321 2019
40
Analysis of patellofemoral arthrokinematic motion quality in open and closed kinetic chains using vibroarthrography. 61
30704430 2019
41
Early movement restriction leads to enduring disorders in muscle and locomotion. 61
29437246 2018
42
Practical Aspects of Hyaluronic Acid Application in Biolevox HA Preparations - Report on Research. 61
30648662 2018
43
Synovial Mesenchymal Stem Cells Derived From the Cotyloid Fossa Synovium Have Higher Self-renewal and Differentiation Potential Than Those From the Paralabral Synovium in the Hip Joint. 61
30215533 2018
44
Interventional Radiology Management of Tracheal and Bronchial Collapse. 61
29941216 2018
45
The association of patellar maltracking with infrapatellar fat pad edema and chondromalacia patella: A quantitative morphological magnetic resonance imaging analysis. 61
31453518 2018
46
Acetabular Focal Chondral Lesions Are Not Associated With Worse Outcomes After Periacetabular Osteotomy: A Matched Group Analyses. 61
29691165 2018
47
Operative findings and complications associated with adjunctive hip arthroscopy in 95 hips undergoing periacetabular osteotomy. 61
29192736 2018
48
Procaine and saline have similar effects on articular cartilage and synovium in rat knee. 61
29743011 2018
49
Osteoarticular Allograft Transplantation of the Trochlear Groove for Trochlear Dysplasia: A Case Report. 61
29742532 2018
50
Does the grading of chondromalacia patellae influence anterior knee pain following total knee arthroplasty without patellar resurfacing? 61
28986675 2018

Variations for Chondromalacia

Expression for Chondromalacia

Search GEO for disease gene expression data for Chondromalacia.

Pathways for Chondromalacia

GO Terms for Chondromalacia

Cellular components related to Chondromalacia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.81 TNF PRTN3 MPO MATN1 IL6 IL1RN
2 extracellular region GO:0005576 9.36 TNFRSF1B TNF PRTN3 MPO MATN1 IL6
3 membrane raft GO:0045121 9.35 TNFRSF1B TNFRSF10A TNF PRTN3 LAX1

Biological processes related to Chondromalacia according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.83 TNFRSF1B TNF LAX1 IL6 IL1RN
2 inflammatory response GO:0006954 9.72 TNFRSF1B TNF IL6 IL1RN CRP
3 defense response to Gram-positive bacterium GO:0050830 9.69 TNF IL6 CRP
4 response to glucocorticoid GO:0051384 9.58 TNF IL6 IL1RN
5 cytokine-mediated signaling pathway GO:0019221 9.55 TNFRSF1B TNF PRTN3 IL6 IL1RN
6 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.52 TNFRSF1B TNF
7 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.49 TNF IL6
8 positive regulation of neuroinflammatory response GO:0150078 9.48 TNF IL6
9 regulation of neuroinflammatory response GO:0150077 9.46 TNFRSF1B IL6
10 extrinsic apoptotic signaling pathway GO:0097191 9.43 TNFRSF1B TNFRSF10A TNF
11 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.37 IL6 IL1RN
12 extracellular matrix organization GO:0030198 9.35 TNF MATN1 IBSP COMP ACAN
13 negative regulation of lipid storage GO:0010888 8.8 TNF IL6 CRP

Molecular functions related to Chondromalacia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 8.8 TNFRSF10A TNF COMP

Sources for Chondromalacia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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