MCID: CHN011
MIFTS: 37

Chondromalacia

Categories: Bone diseases

Aliases & Classifications for Chondromalacia

MalaCards integrated aliases for Chondromalacia:

Name: Chondromalacia 12 74 15 71 32

Classifications:



External Ids:

Disease Ontology 12 DOID:2557
ICD9CM 34 733.92
MeSH 44 D002357
SNOMED-CT 67 63198006
ICD10 32 M94.2
UMLS 71 C0085700

Summaries for Chondromalacia

Disease Ontology : 12 A cartilage disease that is characterized by softening and breakdown of cartilage inside a joint.

MalaCards based summary : Chondromalacia is related to patella, chondromalacia of and relapsing polychondritis. An important gene associated with Chondromalacia is COMP (Cartilage Oligomeric Matrix Protein), and among its related pathways/superpathways are Folate Metabolism and Spinal Cord Injury. The drugs Hyaluronic acid and Methylene blue have been mentioned in the context of this disorder. Affiliated tissues include trachea and bone marrow.

Wikipedia : 74 Chondromalacia patellae (also known as CMP) is an inflammation of the underside of the patella and... more...

Related Diseases for Chondromalacia

Diseases related to Chondromalacia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 439)
# Related Disease Score Top Affiliating Genes
1 patella, chondromalacia of 32.8 IBSP COMP ACAN
2 relapsing polychondritis 31.3 TREM1 MATN1 IL6 CRP COMP
3 enthesopathy 29.8 TNF CRP ACAN
4 bursitis 29.8 TNF IL6 CRP
5 osteoarthritis 29.8 TNF MATN1 IL6 CRP COMP ACAN
6 osteomyelitis 29.8 TNF IL6 CRP
7 arthropathy 29.5 TNF IL6 CRP COMP ACAN
8 gastroesophageal reflux 29.4 TNF MPO IL6
9 tendinitis 29.4 TNF PRTN3 IL6 CRP COMP
10 bone disease 29.4 TNF IL6 IBSP COMP ACAN
11 synovitis 29.0 TNF PRTN3 MATN1 IL6 CRP COMP
12 cranial nerve palsy 10.4 PRTN3 CRP
13 frontal sinusitis 10.3 PRTN3 CRP
14 orbital plasma cell granuloma 10.3 PRTN3 CRP
15 bicipital tenosynovitis 10.3 PRTN3 CRP
16 tolosa-hunt syndrome 10.3 PRTN3 CRP
17 ethmoid sinusitis 10.3 PRTN3 CRP
18 optic papillitis 10.3 TNFRSF10A CRP
19 chronic orbital inflammation 10.3 PRTN3 CRP
20 granulomatous angiitis 10.3 PRTN3 CRP
21 drug reaction with eosinophilia and systemic symptoms 10.3 TNF CRP
22 cholesterol embolism 10.3 PRTN3 CRP
23 ross river fever 10.3 IL6 COMP
24 rheumatoid arthritis interstitial lung disease 10.3 TNF CRP
25 skeletal tuberculosis 10.3 TNF CRP
26 tuberculous epididymitis 10.3 TNF CRP
27 perforated corneal ulcer 10.3 TNFRSF10A CRP
28 splenic tuberculosis 10.3 PRTN3 CRP
29 meningovascular neurosyphilis 10.3 TNF CRP
30 critical illness polyneuropathy 10.3 TNF CRP
31 branch retinal artery occlusion 10.3 PRTN3 CRP
32 louse-borne relapsing fever 10.3 TNF CRP
33 opportunistic bacterial infectious disease 10.3 TNF CRP
34 cogan syndrome 10.3 PRTN3 CRP
35 transient arthritis 10.3 TNFRSF10A IL6
36 dental pulp necrosis 10.3 TNF IBSP
37 tertiary syphilis 10.3 TNF CRP
38 nocardiosis 10.3 TNF CRP
39 arachnoiditis 10.2 TNF CRP
40 soft tissue sarcoma 10.2 TNF CRP
41 gastrointestinal tuberculosis 10.2 TNF CRP
42 intestinal tuberculosis 10.2 TNF CRP
43 oral tuberculosis 10.2 TNF CRP
44 external pathological resorption 10.2 TNF IL6
45 cerebritis 10.2 TNF CRP
46 aspiration pneumonitis 10.2 TNF CRP
47 inflammatory and toxic neuropathy 10.2 TNF CRP
48 discitis 10.2 CRP ACAN
49 granulomatous hepatitis 10.2 TNF CRP
50 cold agglutinin disease 10.2 IL6 CRP

Graphical network of the top 20 diseases related to Chondromalacia:



Diseases related to Chondromalacia

Symptoms & Phenotypes for Chondromalacia

Drugs & Therapeutics for Chondromalacia

Drugs for Chondromalacia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741
2
Methylene blue Approved, Investigational Phase 4 61-73-4
3 Pharmaceutical Solutions Phase 4
4
Lidocaine Approved, Vet_approved 137-58-6 3676
5
Povidone-iodine Approved 25655-41-8
6 neurokinin A
7
Substance P 33507-63-0 44359816
8 Protective Agents
9 Viscosupplements
10 Immunologic Factors
11 Adjuvants, Immunologic
12 Hylan

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Double-blind, Randomized, Post-marketing Surveillance to Evaluate the Efficacy of Intra-articular Collagen Injection in Patients With Knee Joint Pain Compared to Normal Saline Injection Unknown status NCT02539095 Phase 4
2 Injection Site Diversity Influences Sodium Hyaluronate Distribution and Its Clinical Results in Management of Chondromalacia Patellae and Knee Osteoarthritis: A Preliminary, Multi-central, Randomize-controlled Serial Trial Completed NCT03600571 Phase 4
3 Effectiveness of Neuroprolotherapy With Home Physical Therapy Against Isolated Physical Therapy for the Treatment of Patellar Chondromalacia Unknown status NCT03515720
4 Prevalence of Chondromalacia Patella Among Adolescent Dancers - Correlation Between Symptoms and Sonography Findings Unknown status NCT02606942
5 Effect of Pulsed Signal Therapy in Patella Chondromalacia. Randomized Prospective Trial. Completed NCT02012413
6 Prospective, Randomized, Double Blind Evaluation of the Efficacy of a Single Dose of Synvisc-One® (6.0 cc) for the Treatment of Patellofemoral Chondromalacia Completed NCT01771952
7 Temporal Activation of Core Muscles and Vasti in Isolated Patellofemoral Osteoarthritis During Stair-stepping Completed NCT04589702
8 Changes in Quadriceps Function Following Local or Distant Interventions in Individuals With Patellofemoral Pain Completed NCT01434966
9 Effect of Core Stability Exercise on Temporal Activation of Core Muscles and Vasti in Isolated Patellofemoral Osteoarthritis. Recruiting NCT04669834

Search NIH Clinical Center for Chondromalacia

Genetic Tests for Chondromalacia

Anatomical Context for Chondromalacia

MalaCards organs/tissues related to Chondromalacia:

40
Trachea, Bone Marrow

Publications for Chondromalacia

Articles related to Chondromalacia:

(show top 50) (show all 984)
# Title Authors PMID Year
1
Magnetic resonance imaging features of intra-articular tenosynovial giant cell tumor in children. 61
33156428 2021
2
Predictors of Secondary Ulnar Shortening and Reoperation After Arthroscopic TFCC Debridement. 61
33530709 2021
3
An Analysis of Symptomatic Meniscal Re-Tear Incidence in Two Age Populations: Differences in Older versus Younger Adults. 61
31390671 2021
4
Basal joint arthroscopy indications in first CMC joint arthritis. 61
33444782 2021
5
The Benefit of Perineural Injection Treatment with Dextrose for Treatment of Chondromalacia Patella in Participants Receiving Home Physical Therapy: A Pilot Randomized Clinical Trial. 61
33217236 2021
6
Is There a Relationship Between Age, Personal Factors or Surgical Findings, and Outcome After Temporomandibular Joint Arthroscopy? 61
33434521 2020
7
Isolated meniscus extrusion associated with meniscotibial ligament abnormality. 61
31332493 2020
8
The micro-current stimulation of knee acupoints in management of chondromalacia patella: a case report. 61
33281295 2020
9
Patient-specific factors are associated with severity of chondrolabral injury in patients with femoroacetabular impingement. 61
32333055 2020
10
Systematic Review of the Surgical Outcomes of Elbow Plicae. 61
33195708 2020
11
Vibroarthrographic Signal Spectral Features in 5-Class Knee Joint Classification. 61
32899440 2020
12
Patella-patellar tendon angle and lateral patella-tilt angle decrease patients with chondromalacia patella. 61
32451620 2020
13
Correction to: Patella-patellar tendon angle and lateral patella-tilt angle decrease patients with chondromalacia patella. 61
32533224 2020
14
Can Ellipsoid Sign be One of the Earliest Findings of the Medial Femoral Condyle Chondromalacia of Knee Antero Posterior X-Ray? 61
32549968 2020
15
Management of Bone Marrow Lesions of the Hip With Subchondral Calcium Phosphate Injection: Surgical Technique and Tips. 61
32714792 2020
16
Quantitative Knee Arthrography in a Large Animal Model of Osteoarthritis Using Photon-Counting Detector CT. 61
31985604 2020
17
Is Primary Arthroscopic Repair Using the Pulley Technique an Effective Treatment for Partial Proximal ACL Tears? 61
31876551 2020
18
Chondromalacia of the cranial medial femoral condyle; its occurrence and association with clinical outcome in a population of adult horses with stifle lameness. 61
31710379 2020
19
Relation of the chondromalatia patellae to proximal tibial anatomical parameters, assessed with MRI. 61
32324164 2020
20
The relationship between early-onset chondromalacia and the position of the patella. 61
31319691 2020
21
Assessment of the relationship between patellar volume and chondromalacia patellae using knee magnetic resonance imaging. 61
32478301 2020
22
Feasibility of using half-dose Gd-BOPTA for delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) at the knee, compared with standard-dose Gd-DTPA. 61
31141254 2020
23
[Biochemical predictors of cartilaginous tissue metabolic disorders for early osteoarthrosis evidence diagnostics.] 61
32163689 2020
24
Prior Knee Arthroscopy Is Associated With Increased Risk of Revision After Total Knee Arthroplasty. 61
31548115 2020
25
Histological and mechanical comparisons of arytenoid cartilage between 4 brachycephalic and 8 non-brachycephalic dogs: A pilot study. 61
32941546 2020
26
Patellar calcar: morphometric analysis by knee magnetic resonance imaging and three-dimensional reconstruction software-assisted. 61
31529166 2019
27
Joint Space Narrowing in Patients with Femoroacetabular Impingement: A Matched Cohort Study of Military versus Civilian Patients. 61
31125070 2019
28
How Can We Define Clinically Important Improvement in Pain Scores After Hip Arthroscopy for Femoroacetabular Impingement Syndrome? Minimum 2-Year Follow-up Study. 61
31603720 2019
29
Chondromalacia Patella among Military Recruits with Anterior Knee Pain: Prevalence and Association with Patellofemoral Malalignment. 61
31673166 2019
30
Patellofemoral Chondromalacia Does Not Influence Radiographic and Clinical Outcomes following High Tibial Osteotomy. 61
31752024 2019
31
Prevalence and Clinical Implications of Chondral Injuries After Hip Arthroscopic Surgery for Femoroacetabular Impingement Syndrome. 61
31411901 2019
32
Diabetic hip arthropathy is associated with a higher prevalence of femoral head chondromalacia: a case-controlled study. 61
30465436 2019
33
Injury Risk Associated With Sports Specialization and Activity Volume in Youth. 61
31555716 2019
34
Arthroscopic Evaluation of the Subtalar Joint: a Review and Survey of Pathology. 61
31549854 2019
35
Kellgren-Lawrence scoring system underestimates cartilage damage when indicating TKA: preoperative radiograph versus intraoperative photograph. 61
31209613 2019
36
Optimizing Patellofemoral Cartilage Restoration and Instability With Tibial Tubercle Osteotomy. 61
31395155 2019
37
Intra-articular Injection of Type I Atelocollagen to Alleviate Knee Pain: A Double-Blind, Randomized Controlled Trial. 61
31370668 2019
38
Correlation of distraction index with arthroscopic findings in juvenile dogs with hip dysplasia. 61
31222781 2019
39
A novel clinical test for assessing patellar cartilage changes and its correlation with magnetic resonance imaging and arthroscopy. 61
29601214 2019
40
[Hyaluronate acid for treatment of chondromalacia patellae: a 52-week follow-up study]. 61
31340911 2019
41
Bilateral Ulnar Styloid Impaction Syndrome Treated with Ulnar Styloidectomy. 61
31192047 2019
42
The relationship between patellofemoral arthritis and fat tissue volume, body mass index and popliteal artery intima-media thickness through 3T knee MRI 61
31121997 2019
43
Survivorship and Outcome of Hip Arthroscopy for Femoroacetabular Impingement Syndrome Performed With Modern Surgical Techniques. 61
31145663 2019
44
Prospective, Randomized, Double-Blind Evaluation of the Efficacy of a Single-Dose Hyaluronic Acid for the Treatment of Patellofemoral Chondromalacia. 61
31263727 2019
45
A rare complication of knee hematoma after genicular nerve radiofrequency ablation. 61
31583351 2019
46
A Case of Knee Monoarthritis Caused by Mycobacterium Tuberculosis. 61
30982829 2019
47
WHO/ILO work-related burden of disease and injury: Protocol for systematic reviews of exposure to occupational ergonomic risk factors and of the effect of exposure to occupational ergonomic risk factors on osteoarthritis of hip or knee and selected other musculoskeletal diseases. 61
30583853 2019
48
Contrast-enhanced MRI compared to direct joint visualization at arthroscopy in pediatric patients with suspected temporomandibular joint synovitis. 61
30382321 2019
49
Is there a correlation between arthroscopic findings and the clinical signs and symptoms of patients with internal derangement of the temporomandibular joint? A prospective study. 61
30049606 2019
50
Analysis of patellofemoral arthrokinematic motion quality in open and closed kinetic chains using vibroarthrography. 61
30704430 2019

Variations for Chondromalacia

Expression for Chondromalacia

Search GEO for disease gene expression data for Chondromalacia.

Pathways for Chondromalacia

Pathways related to Chondromalacia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.96 TNF MPO IL6 CRP
2 11.66 TNF IL6 ACAN
3 11.61 TNF MPO IL6
4 11.13 TNF IL6 COMP
5 11.01 TNF MPO IL6
6 10.68 MATN1 IBSP COMP ACAN
7 10.64 TNF MPO
8 10.41 TNF IL6 CRP

GO Terms for Chondromalacia

Cellular components related to Chondromalacia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 TNF PRTN3 MPO IL6 IBSP CRP
2 collagen-containing extracellular matrix GO:0062023 9.46 PRTN3 MATN1 COMP ACAN
3 extracellular region GO:0005576 9.32 TREM1 TNF PRTN3 MPO MATN1 IL6

Biological processes related to Chondromalacia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 defense response to Gram-positive bacterium GO:0050830 9.54 CRP IL6 TNF
2 chondrocyte development GO:0002063 9.46 ACAN COMP
3 positive regulation of glial cell proliferation GO:0060252 9.43 IL6 TNF
4 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.4 IL6 TNF
5 extracellular matrix organization GO:0030198 9.35 ACAN COMP IBSP MATN1 TNF
6 humoral immune response GO:0006959 9.33 IL6 TNF TREM1
7 positive regulation of neuroinflammatory response GO:0150078 9.32 IL6 TNF
8 vascular endothelial growth factor production GO:0010573 9.26 IL6 TNF
9 negative regulation of lipid storage GO:0010888 8.8 TNF IL6 CRP

Molecular functions related to Chondromalacia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix structural constituent GO:0005201 9.13 MATN1 COMP ACAN
2 protease binding GO:0002020 8.8 TNFRSF10A TNF COMP

Sources for Chondromalacia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....