Aliases & Classifications for Chondromalacia

MalaCards integrated aliases for Chondromalacia:

Name: Chondromalacia 12 76 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:2557
ICD10 33 M94.2 M94.20
ICD9CM 35 733.92
MeSH 44 D002357
SNOMED-CT 68 63198006
UMLS 73 C0085700

Summaries for Chondromalacia

MalaCards based summary : Chondromalacia is related to patella, chondromalacia of and relapsing polychondritis. An important gene associated with Chondromalacia is COMP (Cartilage Oligomeric Matrix Protein), and among its related pathways/superpathways are ECM proteoglycans and Interleukin-10 signaling. The drugs Hyaluronic acid and Methylene blue have been mentioned in the context of this disorder. Affiliated tissues include bone, trachea and testes, and related phenotypes are cellular and immune system

Wikipedia : 76 Chondromalacia patellae (also known as CMP) is inflammation of the underside of the patella and... more...

Related Diseases for Chondromalacia

Diseases related to Chondromalacia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 41)
# Related Disease Score Top Affiliating Genes
1 patella, chondromalacia of 34.0 COMP GSTO1 IBSP
2 relapsing polychondritis 11.4
3 osteoarthritis 10.2
4 arthritis 10.2
5 tenosynovitis 10.1 COMP TNFRSF1B
6 synovitis 10.0 COMP IL1RN
7 post-transplant lymphoproliferative disease 10.0 TNFRSF10A TNFRSF1B
8 juvenile ankylosing spondylitis 10.0 IL1RN TNFRSF1B
9 spondylitis 10.0 IL1RN TNFRSF1B
10 scleral disease 10.0 IL1RN TNFRSF1B
11 pustulosis of palm and sole 10.0 IL1RN TNFRSF1B
12 palindromic rheumatism 10.0 TNFRSF10A TNFRSF1B
13 orbital cellulitis 10.0 IL1RN TET2
14 acute orbital inflammation 10.0 IL1RN TET2
15 transient arthritis 10.0 COMP TNFRSF10A TNFRSF1B
16 anterior scleritis 9.9 IL1RN TNFRSF1B
17 tracheoesophageal fistula with or without esophageal atresia 9.9
18 aging 9.9
19 joint disorders 9.9
20 esophageal atresia 9.9
21 patellofemoral pain syndrome 9.9
22 enthesopathy 9.9
23 bursitis 9.9
24 tracheal stenosis 9.9
25 arthropathy 9.9
26 acute mountain sickness 9.9
27 tracheoesophageal fistula 9.9
28 central nervous system vasculitis 9.9 SMUG1 TNFRSF10A
29 rectum squamous cell carcinoma 9.9 SMUG1 TNFRSF1B
30 rheumatoid lung disease 9.9 SMUG1 TNFRSF1B
31 granulomatous myositis 9.9 SMUG1 TNFRSF1B
32 exanthem 9.9 IL1RN TNFRSF1B
33 pericardium disease 9.8 IL1RN SMUG1
34 cogan syndrome 9.8 SMUG1 TNFRSF1B
35 tracheal cancer 9.8 SMUG1 TNFRSF1B
36 juvenile rheumatoid arthritis 9.8 IL1RN TNFRSF1B
37 temporal arteritis 9.7 IL1RN SMUG1 TNFRSF10A
38 bone inflammation disease 9.7 COMP IL1RN TNFRSF10A TNFRSF1B
39 hypersensitivity reaction type iv disease 9.7 IL1RN SMUG1 TNFRSF1B
40 rheumatoid arthritis 9.6 COMP IL1RN TNFRSF1B
41 cartilage disease 9.2 COMP GSTO1 IL1RN SMUG1 TET2 TNFRSF10A

Graphical network of the top 20 diseases related to Chondromalacia:



Diseases related to Chondromalacia

Symptoms & Phenotypes for Chondromalacia

MGI Mouse Phenotypes related to Chondromalacia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.63 COMP IL1RN SMUG1 TET2 TNFRSF10A TNFRSF1B
2 immune system MP:0005387 9.43 COMP IBSP IL1RN TET2 TNFRSF10A TNFRSF1B
3 neoplasm MP:0002006 8.92 SMUG1 TET2 TNFRSF10A TNFRSF1B

Drugs & Therapeutics for Chondromalacia

Drugs for Chondromalacia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hyaluronic acid Approved, Vet_approved Phase 4,Not Applicable 9004-61-9 53477741
2
Methylene blue Approved, Investigational Phase 4 61-73-4
3 Pharmaceutical Solutions Phase 4,Not Applicable
4
Povidone-iodine Approved Not Applicable 25655-41-8
5
Lidocaine Approved, Vet_approved Not Applicable 137-58-6 3676
6
Substance P Investigational Not Applicable 33507-63-0 44359816
7 Immunologic Factors Not Applicable
8 Adjuvants, Immunologic Not Applicable
9 Hylan Not Applicable
10 Viscosupplements Not Applicable
11 Protective Agents Not Applicable
12
s 1 (combination) Not Applicable
13 neurokinin A Not Applicable

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Efficacy of Intra-articular Collagen Injection in Patients With Knee Joint Pain Compared to Normal Saline Injection Unknown status NCT02539095 Phase 4
2 Injection Site Diversity Influences HA Distribution and Clinical Results in CP and KOA Completed NCT03600571 Phase 4
3 Prevalence of Chondromalacia Patella Among Adolescent Dancers - Correlation Between Symptoms and Sonography Findings Unknown status NCT02606942
4 Randomized Evaluation of the Efficacy of Synvisc-One® for the Treatment of Patellofemoral Chondromalacia Unknown status NCT01771952 Not Applicable
5 Periacetabular Osteotomy With Versus Without Adjunctive Hip Arthroscopy Unknown status NCT02790749 Not Applicable
6 Effect of Pulsed Signal Therapy in Patella Chondromalacia Completed NCT02012413 Not Applicable
7 The ChAMP (Chondral Lesions And Meniscus Procedures) Trial Completed NCT01527201 Not Applicable
8 Changes in Quadriceps Function Following Local or Distant Interventions in Individuals With Patellofemoral Pain Completed NCT01434966 Not Applicable
9 Study of Platelet-rich Plasma in Treating Patients With Tibiofemoral Cartilage Degeneration Completed NCT01418755 Not Applicable
10 Neuroprolotherapy With Physical Therapy for Treatment of Patellar Chondromalacia Not yet recruiting NCT03515720 Not Applicable
11 Subchondral Perfusion Mapping Using Indocyanin Green Laser Terminated NCT02918383 Not Applicable

Search NIH Clinical Center for Chondromalacia

Genetic Tests for Chondromalacia

Anatomical Context for Chondromalacia

MalaCards organs/tissues related to Chondromalacia:

41
Bone, Trachea, Testes, Lung

Publications for Chondromalacia

Articles related to Chondromalacia:

(show top 50) (show all 272)
# Title Authors Year
1
Investigation of the Relationship between Anterior Knee Pain and Chondromalacia Patellae and Patellofemoral Malalignment. ( 29531488 )
2018
2
Chondromalacia as pathological finding in arthroscopy ofA theA temporomandibular joint: A retrospective study. ( 29229366 )
2018
3
Diabetic hip arthropathy is associated with a higher prevalence of femoral head chondromalacia: a case-controlled study. ( 30465436 )
2018
4
The Relationship between Chondromalacia Patella, Medial Meniscal Tear and Medial Periarticular Bursitis in Patients with Osteoarthritis. ( 29333118 )
2017
5
Association between trochlear morphology and chondromalacia patella: an MRI study. ( 27723501 )
2017
6
Does the grading of chondromalacia patellae influence anterior knee pain following total knee arthroplasty without patellar resurfacing? ( 28986675 )
2017
7
Magnetic Resonance Imaging for Patellofemoral Chondromalacia: Is There a Role for T2 Mapping? ( 29204454 )
2017
8
Preoperative Patellofemoral Chondromalacia is Not a Contraindication for Fixed-Bearing Medial Unicompartmental Knee Arthroplasty. ( 28254376 )
2017
9
Chondromalacia Patella ( 29083563 )
2017
10
The relation between chondromalacia patella and meniscal tear and the sulcus angle/ trochlear depth ratio as a powerful predictor. ( 27911285 )
2016
11
Clinical effect of traditional Chinese spinal orthopedic manipulation in treatment of chondromalacia patellae. ( 29949332 )
2016
12
Sagittal plane tilting deformity of the patellofemoral joint: a new concept in patients with chondromalacia patella. ( 27034088 )
2016
13
Cyclists Have Greater Chondromalacia Index Than Age-Matched Controls at the Time of Hip Arthroscopy. ( 27289277 )
2016
14
A new MRI grading system for chondromalacia patellae. ( 27329395 )
2016
15
Joint Motion Quality in Chondromalacia Progression Assessed by Vibroacoustic Signal Analysis. ( 27060646 )
2016
16
Cystic chondromalacia of the auricle treated with dual-plane excision with intracartilaginous dissection. ( 25255358 )
2014
17
The association of patellofemoral joint morphology with chondromalacia patella: a quantitative MRI analysis. ( 24651059 )
2014
18
T2 mapping in patellar chondromalacia. ( 24713490 )
2014
19
Outcomes of prolotherapy in chondromalacia patella patients: improvements in pain level and function. ( 24596471 )
2014
20
Prevalence and clinical significance of chondromalacia isolated to the anterior margin of the lateral femoral condyle as a component of patellofemoral disease: observations at MR imaging. ( 23689689 )
2013
21
3-D printouts of the tracheobronchial tree generated from CT images as an aid to management in a case of tracheobronchial chondromalacia caused by relapsing polychondritis. ( 24421951 )
2013
22
A novel biological approach to treat chondromalacia patellae. ( 23700485 )
2013
23
Correlation between subcutaneous knee fat thickness and chondromalacia patellae on magnetic resonance imaging of the knee. ( 22884229 )
2013
24
The modified tibial tubercle osteotomy for anterior knee pain due to chondromalacia patellae in adults: A five-year prospective study. ( 23610687 )
2012
25
The role of autologous chondrocyte implantation in the treatment of symptomatic chondromalacia patellae. ( 22246591 )
2012
26
Does posteromedial chondromalacia reduce rate of return to play after ulnar collateral ligament reconstruction? ( 22009711 )
2012
27
Evaluation of the chondromalacia patella using a microscopy coil: comparison of the two-dimensional fast spin echo techniques and the three-dimensional fast field echo techniques. ( 21228943 )
2011
28
Anterior knee pain: the pitfalls of plica and chondromalacia patellae. ( 21699003 )
2011
29
Bone density in patients with chondromalacia patella. ( 19771434 )
2010
30
Capsulolabral advancement for the treatment of glenoid chondromalacia. ( 20608600 )
2010
31
Reliability of clinical findings and magnetic resonance imaging for the diagnosis of chondromalacia patellae. ( 20360517 )
2010
32
Ulnohumeral chondral and ligamentous overload: biomechanical correlation for posteromedial chondromalacia of the elbow in throwing athletes. ( 20829418 )
2010
33
Chondromalacia patellae treated by warming needle and rehabilitation training. ( 19663091 )
2009
34
Open versus closed kinetic chain exercises for patellar chondromalacia in young women. ( 19124993 )
2009
35
Idiopathic tracheal stenosis: a clinicopathologic study of 63 cases and comparison of the pathology with chondromalacia. ( 18545144 )
2008
36
The diagnostic value of the Clarke sign in assessing chondromalacia patella. ( 18345345 )
2008
37
Evaluation of magnetic resonance signal modification induced by hyaluronic acid therapy in chondromalacia patellae: a preliminary study. ( 19036227 )
2008
38
Open versus closed kinetic chain exercises for patellar chondromalacia. ( 17615174 )
2008
39
MRI quantitative morphologic analysis of patellofemoral region: lack of correlation with chondromalacia patellae at surgery. ( 17954655 )
2007
40
Arthroscopic debridement for grade III and IV chondromalacia of the knee in patients older than 60 years. ( 17993066 )
2007
41
Retropatellar chondromalacia associated with medial osteoarthritis after meniscus injury. One year of observations in sheep. ( 16699283 )
2006
42
Chondromalacia of trochlear notch after healing of olecranon stress fracture: a case report. ( 16237533 )
2006
43
Acetabular labral tears with underlying chondromalacia: a possible association with high-level running. ( 15891725 )
2005
44
Lunate chondromalacia: evaluation of routine MRI sequences. ( 15855097 )
2005
45
Evaluation of patellar chondromalacia with MR: comparison between T2-weighted FSE SPIR and GE MTC. ( 15343130 )
2004
46
Chondromalacia of sesamoids in first metatarsophalangeal joint. ( 15294134 )
2004
47
A correlative study between prevalence of chondromalacia patellae and sports injury in 4068 students. ( 14642059 )
2003
48
MR arthrography in chondromalacia patellae diagnosis on a low-field open magnet system. ( 12727059 )
2003
49
Cystic chondromalacia of the ear. ( 12619465 )
2003
50
Dynamics of muscle strength improvement during isokinetic rehabilitation of athletes with ACL rupture and chondromalacia patellae. ( 12629465 )
2003

Variations for Chondromalacia

Expression for Chondromalacia

Search GEO for disease gene expression data for Chondromalacia.

Pathways for Chondromalacia

Pathways related to Chondromalacia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.71 COMP IBSP
2 10.31 IL1RN TNFRSF1B

GO Terms for Chondromalacia

Biological processes related to Chondromalacia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular response to growth factor stimulus GO:0071363 8.96 IBSP TNFRSF1B
2 extrinsic apoptotic signaling pathway GO:0097191 8.62 TNFRSF10A TNFRSF1B

Molecular functions related to Chondromalacia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 8.62 COMP TNFRSF10A

Sources for Chondromalacia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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