MCID: CHN053
MIFTS: 39

Chondromyxoid Fibroma

Categories: Bone diseases, Rare diseases

Aliases & Classifications for Chondromyxoid Fibroma

MalaCards integrated aliases for Chondromyxoid Fibroma:

Name: Chondromyxoid Fibroma 58 17 70
Fibroma Chondromyxoid 54

Characteristics:

Orphanet epidemiological data:

58
chondromyxoid fibroma
Inheritance: Not applicable; Prevalence: <1/1000000 (Worldwide); Age of onset: Adult;

Classifications:

Orphanet: 58  
Rare bone diseases


External Ids:

ICD10 via Orphanet 33 D16.9
UMLS via Orphanet 71 C0221290
Orphanet 58 ORPHA404507
UMLS 70 C0221290

Summaries for Chondromyxoid Fibroma

MalaCards based summary : Chondromyxoid Fibroma, also known as fibroma chondromyxoid, is related to fibroma and rare tumor, and has symptoms including pain An important gene associated with Chondromyxoid Fibroma is GRM1 (Glutamate Metabotropic Receptor 1), and among its related pathways/superpathways are ERK Signaling and Endometrial cancer. Affiliated tissues include bone, spinal cord and smooth muscle, and related phenotypes are behavior/neurological and cellular

Wikipedia : 73 Chondromyxoid fibroma is a rare type of cartilaginous tumor. Rarely occur in the skull or skull... more...

Related Diseases for Chondromyxoid Fibroma

Diseases related to Chondromyxoid Fibroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 201)
# Related Disease Score Top Affiliating Genes
1 fibroma 31.9 VIM S100A1 DES ACTC1
2 rare tumor 31.2 DES ACTC1
3 osteogenic sarcoma 30.6 PTHLH PTH1R CDKN2A CDKN1A
4 chondroblastoma 30.3 SOX9 S100A2 PTHLH PTH1R FGFR3
5 chondrosarcoma 30.3 VIM SOX9 S100A1 PTHLH FGFR3 COL10A1
6 chondroid chordoma 30.2 VIM S100A1
7 neurilemmoma 30.1 VIM S100A1 DES ACTC1
8 chordoma 30.0 VIM SOX9 S100A1 DES CDKN2A
9 mesenchymal chondrosarcoma 30.0 VIM SOX9 DES
10 synovial chondromatosis 30.0 SOX9 FGFR3
11 sarcoma, synovial 29.7 VIM DES BCL2
12 osteochondroma 29.5 VIM PTHLH FGFR3 CDKN1A BCL2
13 fibrosarcoma 28.8 VIM TGFB1 SERPINE1 DES CDKN1A ACTC1
14 chondroma 10.6
15 aneurysmal bone cysts 10.5
16 primary bone cancer 10.4
17 histiocytic sarcoma 10.3 CDKN2A BCL2
18 fibroblastic rheumatism 10.3 DES ACTC1
19 ovarian fibrothecoma 10.3 DES ACTC1
20 bowenoid papulosis 10.3 CDKN2A CCND1
21 esophagus verrucous carcinoma 10.3 CDKN2A CCND1
22 myxoid chondrosarcoma 10.3
23 exophthalmos 10.3
24 enchondroma 10.3
25 back pain 10.3
26 human papillomavirus infectious disease 10.3 CDKN2A CDKN1A
27 bizarre leiomyoma 10.3 CDKN2A ACTC1
28 adult cystic nephroma 10.3 DES ACTC1
29 pulmonary vein stenosis 10.3 DES ACTC1
30 actinic cheilitis 10.3 FGFR3 CDKN1A
31 tonsil squamous cell carcinoma 10.3 CDKN2A CCND1
32 botryoid rhabdomyosarcoma 10.3 DES ACTC1
33 conjunctival intraepithelial neoplasm 10.3 S100A2 S100A1
34 ectomesenchymoma 10.2 S100A1 DES
35 lymphangiectasis 10.2 VIM ACTC1
36 extramedullary plasmacytoma 10.2 CDKN1A CCND1 BCL2
37 suppressor of tumorigenicity 3 10.2 CDKN2A CDKN1A BCL2
38 intravascular papillary endothelial hyperplasia 10.2 VIM ACTC1
39 glomangiomyoma 10.2 VIM ACTC1
40 papillary tumor of the pineal region 10.2 VIM S100A1
41 eiken syndrome 10.2 PTHLH PTH1R
42 plasmablastic lymphoma 10.2 DES CDKN2A
43 angiocentric glioma 10.2 VIM ACTC1
44 hypercalcemia, infantile, 1 10.2 PTHLH PTH1R
45 endometrial mucinous adenocarcinoma 10.2 VIM CDKN2A
46 osteoid osteoma 10.2
47 meningioma, familial 10.2
48 intracranial meningioma 10.2
49 osteomalacia 10.2
50 juxtacortical chondroma 10.2

Graphical network of the top 20 diseases related to Chondromyxoid Fibroma:



Diseases related to Chondromyxoid Fibroma

Symptoms & Phenotypes for Chondromyxoid Fibroma

UMLS symptoms related to Chondromyxoid Fibroma:


pain

MGI Mouse Phenotypes related to Chondromyxoid Fibroma:

46 (show all 22)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.47 BCL2 CCND1 CDKN1A CDKN2A COL10A1 COL12A1
2 cellular MP:0005384 10.46 ACTC1 BCL2 CCND1 CDKN1A CDKN2A COL10A1
3 cardiovascular system MP:0005385 10.4 ACTC1 BCL2 CCND1 CDKN1A CDKN2A DES
4 homeostasis/metabolism MP:0005376 10.4 ACTC1 BCL2 CCND1 CDKN1A CDKN2A DES
5 growth/size/body region MP:0005378 10.39 ACTC1 BCL2 CCND1 CDKN1A CDKN2A COL10A1
6 mortality/aging MP:0010768 10.36 ACTC1 BCL2 CCND1 CDKN1A CDKN2A COL10A1
7 hematopoietic system MP:0005397 10.35 ACTC1 BCL2 CCND1 CDKN1A CDKN2A COL10A1
8 immune system MP:0005387 10.29 BCL2 CCND1 CDKN1A CDKN2A COL10A1 FGFR3
9 craniofacial MP:0005382 10.27 ACTC1 BCL2 CCND1 CDKN1A COL10A1 FGFR3
10 digestive/alimentary MP:0005381 10.22 BCL2 CCND1 CDKN1A CDKN2A FGFR3 PTH1R
11 endocrine/exocrine gland MP:0005379 10.21 BCL2 CCND1 CDKN1A CDKN2A COL10A1 PTH1R
12 integument MP:0010771 10.19 BCL2 CCND1 CDKN1A CDKN2A FGFR3 GRM1
13 nervous system MP:0003631 10.18 ACTC1 BCL2 CCND1 CDKN1A CDKN2A COL10A1
14 muscle MP:0005369 10.17 ACTC1 BCL2 CDKN1A CDKN2A COL12A1 DES
15 adipose tissue MP:0005375 10.15 BCL2 CDKN1A GRM1 PTHLH SERPINE1 SOX9
16 neoplasm MP:0002006 10.1 BCL2 CCND1 CDKN1A CDKN2A FGFR3 GRM1
17 limbs/digits/tail MP:0005371 10.02 CDKN1A COL10A1 COL12A1 FGFR3 PTH1R PTHLH
18 reproductive system MP:0005389 9.96 BCL2 CCND1 CDKN1A CDKN2A FGFR3 GRM1
19 renal/urinary system MP:0005367 9.92 BCL2 CDKN1A FGFR3 GRM1 PTHLH SERPINE1
20 respiratory system MP:0005388 9.9 CCND1 CDKN1A CDKN2A FGFR3 PTH1R PTHLH
21 skeleton MP:0005390 9.73 CCND1 CDKN1A CDKN2A COL10A1 COL12A1 FGFR3
22 vision/eye MP:0005391 9.36 BCL2 CCND1 CDKN1A CDKN2A FGFR3 GRM1

Drugs & Therapeutics for Chondromyxoid Fibroma

Search Clinical Trials , NIH Clinical Center for Chondromyxoid Fibroma

Genetic Tests for Chondromyxoid Fibroma

Anatomical Context for Chondromyxoid Fibroma

MalaCards organs/tissues related to Chondromyxoid Fibroma:

40
Bone, Spinal Cord, Smooth Muscle

Publications for Chondromyxoid Fibroma

Articles related to Chondromyxoid Fibroma:

(show top 50) (show all 512)
# Title Authors PMID Year
1
[Chondromyxoid fibroma]. 61 54
17642191 2007
2
Sclerosing epithelioid fibrosarcoma of bone: morphological, immunophenotypical, and molecular findings of 9 cases. 61
33084978 2021
3
Subperiosteal chondromyxoid fibroma: a rare case involving the humeral diaphysis. 61
32803376 2021
4
Fine-Needle Aspiration Cytology in Preoperative Diagnosis of Bone Lesions: A Three-Year Study in a Tertiary Care Hospital. 61
33181515 2021
5
H3F3A G34 mutation DNA sequencing and G34W immunohistochemistry analysis in 366 cases of giant cell tumors of bone and other bone tumors. 61
33021329 2021
6
Chondromyxoid Fibroma of the Sacral Spine. 61
32362154 2020
7
Chondromyxoid fibroma of the nasal cavity - A rare tumor at an unusual site. 61
33154331 2020
8
Secondary aneurysmal bone cysts and associated primary lesions: imaging features of 49 cases. 61
32036238 2020
9
Chondromyxoid Fibroma of the Mastoid: A Rare Entity with Comprehensive Literature Review. 61
32209521 2020
10
Chondromyxoid fibroma of the temporal bone: A rare case report. 61
32176085 2020
11
Soft Tissue Special Issue: Chondroid Neoplasms of the Skull. 61
31950468 2020
12
Utility of FOS as diagnostic marker for osteoid osteoma and osteoblastoma. 61
31768625 2020
13
Chondromyxoid Fibroma of Distal Phalanx of the Great Toe: A Rare Clinical Entity. 61
32257678 2020
14
Chondromyxoid fibroma-like osteosarcoma: a case series and literature review. 61
31996205 2020
15
Primary chondromyxoid fibroma of the orbit: An orbital mass with calcification. 61
31755478 2019
16
Sinonasal Chondromyxoid Fibroma: Case Report and Literature Review. 61
31754576 2019
17
Chondromyxoid Fibroma of the Pelvis: Institutional Case Series With a Focus on Distinctive Features. 61
30580642 2019
18
Surface-type chondromyxoid fibroma in an elderly patient: a case report and literature review. 61
30498967 2019
19
[Chondromucinous tumors involving craniocerebral slope area: a clinicopathological analysis of eight cases]. 61
30831645 2019
20
An update of molecular pathology of bone tumors. Lessons learned from investigating samples by next generation sequencing. 61
30582658 2019
21
Histone H3K36M mutation and trimethylation patterns in chondroblastoma. 61
30098026 2019
22
Diagnosis and Literature Review of Chondromyxoid Fibroma - A Pathological Puzzle. 61
32405500 2019
23
Chondromyxoid fibroma of the temporal bone: A case report and review of the literature. 61
30613685 2018
24
Chondromyxoid fibroma with a secondary aneurysmal bone cyst of the distal radius: A case report. 61
30580890 2018
25
Treatment of cryotherapy and orthotopic transplantation following chondromyxoid fibroma of zygomatic bone: A case report. 61
30075574 2018
26
Fluorescent In Situ Hybridization for TP53 in the Diagnosis of Pediatric Osteogenic Sarcoma. 61
29543677 2018
27
A case report on partial scapulectomy with glenoid preservation for Chondromyxoid fibroma of scapula. 61
29628714 2018
28
Chondromyxoid Fibroma Arising in Craniofacial Sites: A Clinicopathologic Analysis of 25 Cases. 61
29324473 2018
29
Benign Chondromyxoid Fibroma of the Iliac Crest. 61
29385939 2018
30
Chondromyxoid Fibroma of the Metatarsal Bone: A Diagnosis Using Fine Needle Aspiration Biopsy. 61
29403178 2018
31
Huge chondromyxoid fibroma of the right iliac wing with tremendous soft tissue extensions. 61
30363225 2018
32
An intracortical chondromyxoid fibroma in the diaphysis of the metatarsal. 61
28808739 2017
33
Radiological presentation of chondromyxoid fibroma in the sellar region: A CARE-compliant article and literature review. 61
29245307 2017
34
Chondromyxoid fibroma : a case report. 61
29877562 2017
35
Chondromyxoid Fibroma of the Skull Base: Our Experience with an Elusive Disease. 61
28255973 2017
36
Phosphaturic Mesenchymal Tumors: Clinicopathologic, Immunohistochemical and Molecular Analysis of 22 Cases Expanding their Morphologic and Immunophenotypic Spectrum. 61
28614212 2017
37
[Effectiveness of unicompartment allografts replacement for bone tumor around the knee]. 61
29806423 2017
38
Benign Bone Conditions That May Be FDG-avid and Mimic Malignancy. 61
28583274 2017
39
Chondromyxoid fibroma of the distal fibula treated by percutaneous radiofrequency ablation. 61
28731366 2017
40
Primary Orbital Chondromyxoid Fibroma: A Rare Case. 61
28099230 2017
41
Pediatric Chondromyxoid Fibroma-Like Osteosarcoma. 61
27935335 2017
42
Exceptional Rare Giant Craniofacial Chondroid Tumor in Adult. 61
28003165 2017
43
Long-lasting chondromyxoid fibroma of the zygoma: A rare case report and review of literature. 61
28852667 2017
44
[Rare location of chondromyxoid fibroma: about a case]. 61
28690733 2017
45
[Chondromyxoid fibroma of the mandible: a case report]. 61
28318171 2016
46
Acute cauda equina syndrome secondary to chondromyxoid fibroma of the lumbar spine. 61
26882861 2016
47
Chondromyxoid Fibroma: A Rare Case Report and Review of Literature. 61
27833828 2016
48
Imaging features of chondromyxoid fibroma: report of 15 cases and literature review. 61
27226218 2016
49
Decalcified allograft in repair of lytic lesions of bone: A study to evolve bone bank in developing countries. 61
27512226 2016
50
[EFFICACY OF BIOACTIVE GLASS AND ALLOGENIC BONE IN REPAIR OF BONE DEFECT AFTER BENIGN BONE TUMOR CURETTAGE]. 61
29786274 2016

Variations for Chondromyxoid Fibroma

Copy number variations for Chondromyxoid Fibroma from CNVD:

7
# CNVD ID Chromosome Start End Type Gene Symbol CNVD Disease
1 206032 6 135200000 139100000 Gain BCLAF1 Chondromyxoid Fibroma
2 215014 6 70000000 75900000 Gain COL12A1 Chondromyxoid Fibroma
3 215892 6 82700000 149100000 Deletion UTRN Chondromyxoid Fibroma

Expression for Chondromyxoid Fibroma

Search GEO for disease gene expression data for Chondromyxoid Fibroma.

Pathways for Chondromyxoid Fibroma

Pathways related to Chondromyxoid Fibroma according to GeneCards Suite gene sharing:

(show all 42)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.71 VIM TGFB1 SOX9 FGFR3 COL12A1 COL10A1
2
Show member pathways
12.81 TGFB1 CDKN2A CDKN1A CCND1 BCL2
3 12.75 TGFB1 FGFR3 CDKN2A CDKN1A CCND1 BCL2
4
Show member pathways
12.69 TGFB1 CDKN2A CDKN1A CCND1 BCL2
5
Show member pathways
12.54 TGFB1 FGFR3 CDKN1A CCND1 BCL2
6 12.45 VIM CDKN2A CDKN1A CCND1
7 12.34 VIM FGFR3 CDKN2A CDKN1A CCND1 BCL2
8 12.3 TGFB1 CDKN2A CDKN1A CCND1
9
Show member pathways
12.28 TGFB1 CDKN2A CDKN1A CCND1
10 12.27 TGFB1 CDKN2A CDKN1A CCND1
11
Show member pathways
12.25 SERPINE1 CDKN2A CDKN1A CCND1 BCL2
12
Show member pathways
12.17 FGFR3 CDKN1A CCND1 BCL2
13
Show member pathways
12.15 TGFB1 CDKN2A CDKN1A CCND1
14 12.02 TGFB1 SERPINE1 CDKN2A CDKN1A CCND1
15
Show member pathways
12.01 TGFB1 GRM1 CDKN1A CCND1
16 11.99 SERPINE1 S100A2 CDKN1A BCL2
17 11.94 VIM TGFB1 SOX9 CCND1
18 11.91 CDKN2A CDKN1A CCND1
19 11.9 SERPINE1 CDKN1A BCL2
20 11.85 PTHLH PTH1R CDKN1A BCL2
21 11.83 TGFB1 SOX9 DES
22 11.81 CDKN1A CCND1 BCL2
23 11.81 TGFB1 SERPINE1 CCND1 BCL2
24 11.74 VIM SOX9 FGFR3
25 11.73 CDKN1A CCND1 BCL2
26 11.72 TGFB1 CDKN2A CDKN1A CCND1 BCL2
27 11.7 VIM TGFB1 CDKN1A
28 11.69 CDKN2A CDKN1A BCL2
29 11.68 VIM DES ACTC1
30 11.68 TGFB1 SERPINE1 CDKN1A
31 11.63 TGFB1 CDKN2A CDKN1A BCL2
32 11.62 FGFR3 CDKN2A CDKN1A CCND1
33 11.61 VIM TGFB1 CDKN1A CCND1 BCL2
34 11.58 CDKN1A CCND1 BCL2
35 11.49 TGFB1 CDKN1A CCND1
36 11.46 TGFB1 SERPINE1 COL10A1 CDKN2A CDKN1A BCL2
37 11.35 PTHLH PTH1R CCND1
38 11.33 CDKN2A CDKN1A CCND1 BCL2
39
Show member pathways
11.01 CDKN2A CDKN1A BCL2
40 10.91 TGFB1 SOX9 PTHLH PTH1R FGFR3 COL10A1
41 10.85 VIM TGFB1 FGFR3 DES COL12A1 COL10A1
42 10.82 TGFB1 BCL2

GO Terms for Chondromyxoid Fibroma

Cellular components related to Chondromyxoid Fibroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.44 VIM TGFB1 SOX9 S100A1 PTHLH PTH1R

Biological processes related to Chondromyxoid Fibroma according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.97 VIM TGFB1 SOX9 CDKN2A ACTC1
2 response to drug GO:0042493 9.83 TGFB1 CDKN1A CCND1 BCL2 ACTC1
3 cytokine-mediated signaling pathway GO:0019221 9.8 VIM TGFB1 CDKN1A CCND1 BCL2
4 positive regulation of cell proliferation GO:0008284 9.8 TGFB1 SOX9 PTHLH PTH1R FGFR3 CCND1
5 cellular calcium ion homeostasis GO:0006874 9.79 TGFB1 PTH1R BCL2
6 ossification GO:0001503 9.79 SOX9 PTH1R BCL2
7 G1/S transition of mitotic cell cycle GO:0000082 9.78 CDKN2A CDKN1A CCND1
8 female pregnancy GO:0007565 9.77 TGFB1 PTHLH BCL2
9 response to organic substance GO:0010033 9.76 TGFB1 CDKN1A CCND1
10 negative regulation of cell growth GO:0030308 9.76 TGFB1 CDKN2A CDKN1A BCL2
11 response to glucocorticoid GO:0051384 9.73 CDKN1A CCND1 BCL2
12 negative regulation of G1/S transition of mitotic cell cycle GO:2000134 9.72 CDKN2A CDKN1A BCL2
13 animal organ regeneration GO:0031100 9.69 TGFB1 CDKN1A CCND1
14 bone mineralization GO:0030282 9.67 PTHLH PTH1R FGFR3
15 muscle filament sliding GO:0030049 9.65 VIM DES ACTC1
16 apoptotic mitochondrial changes GO:0008637 9.62 CDKN2A BCL2
17 negative regulation of epithelial cell differentiation GO:0030857 9.59 SOX9 CCND1
18 negative regulation of biomineral tissue development GO:0070168 9.57 TGFB1 SOX9
19 skeletal system development GO:0001501 9.55 SOX9 PTHLH PTH1R FGFR3 COL10A1
20 heart valve morphogenesis GO:0003179 9.54 TGFB1 SOX9
21 negative regulation of ossification GO:0030279 9.54 TGFB1 SOX9 BCL2
22 positive regulation of extracellular matrix assembly GO:1901203 9.52 TGFB1 SOX9
23 replicative senescence GO:0090399 9.5 SERPINE1 CDKN2A CDKN1A
24 chondrocyte differentiation GO:0002062 9.26 TGFB1 SOX9 PTH1R FGFR3
25 negative regulation of cell proliferation GO:0008285 9.17 TGFB1 SOX9 PTHLH PTH1R CDKN2A CDKN1A

Molecular functions related to Chondromyxoid Fibroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.23 VIM TGFB1 S100A2 S100A1 GRM1 FGFR3
2 cyclin-dependent protein serine/threonine kinase inhibitor activity GO:0004861 8.96 CDKN2A CDKN1A

Sources for Chondromyxoid Fibroma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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