MCID: CHN053
MIFTS: 43

Chondromyxoid Fibroma

Categories: Bone diseases, Rare diseases

Aliases & Classifications for Chondromyxoid Fibroma

MalaCards integrated aliases for Chondromyxoid Fibroma:

Name: Chondromyxoid Fibroma 60 17 74
Fibroma Chondromyxoid 56

Characteristics:

Orphanet epidemiological data:

60
chondromyxoid fibroma
Inheritance: Not applicable; Prevalence: <1/1000000 (Worldwide); Age of onset: Adult;

Classifications:

Orphanet: 60  
Rare bone diseases


External Ids:

ICD10 via Orphanet 35 D16.9
UMLS via Orphanet 75 C0221290
Orphanet 60 ORPHA404507
UMLS 74 C0221290

Summaries for Chondromyxoid Fibroma

MalaCards based summary : Chondromyxoid Fibroma, also known as fibroma chondromyxoid, is related to chondroblastoma and giant cell tumor, and has symptoms including pain An important gene associated with Chondromyxoid Fibroma is GRM1 (Glutamate Metabotropic Receptor 1), and among its related pathways/superpathways are ERK Signaling and Endometrial cancer. Affiliated tissues include bone and spinal cord, and related phenotypes are behavior/neurological and cellular

Wikipedia : 77 Chondromyxoid fibroma is a type of cartilaginous... more...

Related Diseases for Chondromyxoid Fibroma

Diseases related to Chondromyxoid Fibroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 109)
# Related Disease Score Top Affiliating Genes
1 chondroblastoma 31.1 PTH1R PTHLH SOX9
2 giant cell tumor 30.5 ACTC1 DES VIM
3 mesenchymal chondrosarcoma 30.4 DES SOX9 VIM
4 chordoma 29.9 CDKN2A DES S100A1 VIM
5 fibroma 11.4
6 chondrosarcoma 10.6
7 aneurysmal bone cysts 10.5
8 lymphangiectasis 10.4 ACTC1 VIM
9 glomangiomyoma 10.4 ACTC1 VIM
10 infantile digital fibromatosis 10.4 DES VIM
11 intravascular papillary endothelial hyperplasia 10.4 ACTC1 VIM
12 lymphoma, small cleaved-cell, diffuse 10.4 BCL2 CCND1
13 lymphangiomatosis 10.4 DES VIM
14 ovarian fibrothecoma 10.4 ACTC1 DES
15 histiocytic sarcoma 10.4 BCL2 CDKN2A
16 fibroblastic rheumatism 10.4 ACTC1 DES
17 primitive neuroectodermal tumor of the cervix uteri 10.4 DES VIM
18 breast papillomatosis 10.4 CCND1 CDKN2A
19 malignant peritoneal mesothelioma 10.4 CDKN2A VIM
20 cutaneous leiomyosarcoma 10.3 ACTC1 DES
21 botryoid rhabdomyosarcoma 10.3 ACTC1 DES
22 bizarre leiomyoma 10.3 ACTC1 CDKN2A
23 tooth ankylosis 10.3 PTH1R PTHLH
24 tonsil squamous cell carcinoma 10.3 CCND1 CDKN2A
25 clear cell chondrosarcoma 10.3 PTH1R PTHLH
26 angiolipoma 10.3 ACTC1 DES VIM
27 spindle cell lipoma 10.3 ACTC1 DES VIM
28 parachordoma 10.3 ACTC1 DES VIM
29 syringocystadenoma papilliferum 10.3 ACTC1 DES VIM
30 ossifying fibromyxoid tumor 10.3 ACTC1 DES VIM
31 epithelioid leiomyosarcoma 10.3 ACTC1 DES VIM
32 suppressor of tumorigenicity 3 10.3 BCL2 CDKN1A CDKN2A
33 perivascular epithelioid cell tumor 10.3 ACTC1 DES VIM
34 cutaneous fibrous histiocytoma 10.3 ACTC1 DES VIM
35 epulis 10.3 DES VIM
36 fibrous histiocytoma 10.3 ACTC1 DES VIM
37 congenital fibrosarcoma 10.3 ACTC1 DES VIM
38 pseudosarcomatous fibromatosis 10.3 ACTC1 DES VIM
39 glomangioma 10.3 ACTC1 DES
40 fibromatosis 10.3 ACTC1 DES VIM
41 plasma cell leukemia 10.3 CCND1 FGFR3
42 glomus tumor 10.3 ACTC1 DES VIM
43 spindle cell sarcoma 10.3 ACTC1 DES VIM
44 smooth muscle tumor 10.3 ACTC1 DES VIM
45 hemangiopericytoma, malignant 10.3 ACTC1 DES VIM
46 pleomorphic liposarcoma 10.3 CDKN2A DES VIM
47 liposarcoma 10.3 CDKN2A DES VIM
48 infantile myofibromatosis 10.3 ACTC1 DES VIM
49 malignant fibroxanthoma 10.3 ACTC1 DES VIM
50 hidradenocarcinoma 10.3 BCL2 CCND1 VIM

Graphical network of the top 20 diseases related to Chondromyxoid Fibroma:



Diseases related to Chondromyxoid Fibroma

Symptoms & Phenotypes for Chondromyxoid Fibroma

UMLS symptoms related to Chondromyxoid Fibroma:


pain

MGI Mouse Phenotypes related to Chondromyxoid Fibroma:

47 (show all 22)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.47 BCL2 CCND1 CDKN1A CDKN2A COL10A1 COL12A1
2 cellular MP:0005384 10.46 ACTC1 BCL2 CCND1 CDKN1A CDKN2A COL10A1
3 cardiovascular system MP:0005385 10.4 ACTC1 BCL2 CCND1 CDKN1A CDKN2A DES
4 homeostasis/metabolism MP:0005376 10.4 ACTC1 BCL2 CCND1 CDKN1A CDKN2A DES
5 growth/size/body region MP:0005378 10.39 ACTC1 BCL2 CCND1 CDKN1A CDKN2A COL10A1
6 mortality/aging MP:0010768 10.36 ACTC1 BCL2 CCND1 CDKN1A CDKN2A COL10A1
7 hematopoietic system MP:0005397 10.31 BCL2 CCND1 CDKN1A CDKN2A COL10A1 FGFR3
8 immune system MP:0005387 10.29 BCL2 CCND1 CDKN1A CDKN2A COL10A1 FGFR3
9 craniofacial MP:0005382 10.23 BCL2 CCND1 CDKN1A COL10A1 FGFR3 PTH1R
10 digestive/alimentary MP:0005381 10.22 BCL2 CCND1 CDKN1A CDKN2A FGFR3 PTH1R
11 endocrine/exocrine gland MP:0005379 10.21 BCL2 CCND1 CDKN1A CDKN2A COL10A1 PTH1R
12 integument MP:0010771 10.19 BCL2 CCND1 CDKN1A CDKN2A FGFR3 GRM1
13 muscle MP:0005369 10.17 ACTC1 BCL2 CDKN1A CDKN2A COL12A1 DES
14 adipose tissue MP:0005375 10.15 BCL2 CDKN1A GRM1 PTHLH SERPINE1 SOX9
15 nervous system MP:0003631 10.15 BCL2 CCND1 CDKN1A CDKN2A COL10A1 FGFR3
16 neoplasm MP:0002006 10.1 BCL2 CCND1 CDKN1A CDKN2A FGFR3 GRM1
17 limbs/digits/tail MP:0005371 10.02 CDKN1A COL10A1 COL12A1 FGFR3 PTH1R PTHLH
18 reproductive system MP:0005389 9.96 BCL2 CCND1 CDKN1A CDKN2A FGFR3 GRM1
19 renal/urinary system MP:0005367 9.92 BCL2 CDKN1A FGFR3 GRM1 PTHLH SERPINE1
20 respiratory system MP:0005388 9.9 CCND1 CDKN1A CDKN2A FGFR3 PTH1R PTHLH
21 skeleton MP:0005390 9.7 CCND1 CDKN1A CDKN2A COL10A1 COL12A1 FGFR3
22 vision/eye MP:0005391 9.36 BCL2 CCND1 CDKN1A CDKN2A FGFR3 GRM1

Drugs & Therapeutics for Chondromyxoid Fibroma

Search Clinical Trials , NIH Clinical Center for Chondromyxoid Fibroma

Genetic Tests for Chondromyxoid Fibroma

Anatomical Context for Chondromyxoid Fibroma

MalaCards organs/tissues related to Chondromyxoid Fibroma:

42
Bone, Spinal Cord

Publications for Chondromyxoid Fibroma

Articles related to Chondromyxoid Fibroma:

(show top 50) (show all 316)
# Title Authors Year
1
Chondromyxoid Fibroma of the Metatarsal Bone: A Diagnosis Using Fine Needle Aspiration Biopsy. ( 29403178 )
2018
2
Chondromyxoid Fibroma Arising in Craniofacial Sites: A Clinicopathologic Analysis of 25 Cases. ( 29324473 )
2018
3
Benign Chondromyxoid Fibroma of the Iliac Crest. ( 29385939 )
2018
4
A case report on partial scapulectomy with glenoid preservation for Chondromyxoid fibroma of scapula. ( 29628714 )
2018
5
Treatment of cryotherapy and orthotopic transplantation following chondromyxoid fibroma of zygomatic bone: A case report. ( 30075574 )
2018
6
Huge chondromyxoid fibroma of the right iliac wing with tremendous soft tissue extensions. ( 30363225 )
2018
7
Surface-type chondromyxoid fibroma in an elderly patient: a case report and literature review. ( 30498967 )
2018
8
Chondromyxoid Fibroma of the Pelvis: Institutional Case Series With a Focus on Distinctive Features. ( 30580642 )
2018
9
Chondromyxoid fibroma with a secondary aneurysmal bone cyst of the distal radius: A case report. ( 30580890 )
2018
10
Chondromyxoid fibroma of the temporal bone: A case report and review of the literature. ( 30613685 )
2018
11
Radiological presentation of chondromyxoid fibroma in the sellar region: A CARE-compliant article and literature review. ( 29245307 )
2017
12
Primary Orbital Chondromyxoid Fibroma: A Rare Case. ( 28099230 )
2017
13
Chondromyxoid Fibroma of the Skull Base: Our Experience with an Elusive Disease. ( 28255973 )
2017
14
Long-lasting chondromyxoid fibroma of the zygoma: A rare case report and review of literature. ( 28852667 )
2017
15
Chondromyxoid fibroma of the distal fibula treated by percutaneous radiofrequency ablation. ( 28731366 )
2017
16
Chondromyxoid fibroma : a case report. ( 29877562 )
2017
17
An intracortical chondromyxoid fibroma in the diaphysis of the metatarsal. ( 28808739 )
2017
18
Chondromyxoid Fibroma of Radius: A Case Report. ( 27437232 )
2016
19
Acute cauda equina syndrome secondary to chondromyxoid fibroma of the lumbar spine. ( 26882861 )
2016
20
Chondromyxoid fibroma of the sacrum: A case report and literature review. ( 27274412 )
2016
21
Pediatric Chondromyxoid Fibroma-Like Osteosarcoma. ( 27935335 )
2016
22
Chondromyxoid Fibroma of the Skull Base and Calvarium: Surgical Management and Literature Review. ( 26929898 )
2016
23
Rare case of sacral mass due to chondromyxoid fibroma. ( 26961558 )
2016
24
Imaging features of chondromyxoid fibroma: report of 15 cases and literature review. ( 27226218 )
2016
25
Chondromyxoid fibroma of the pubic ramus: a case report and literature review. ( 26854059 )
2016
26
Chondromyxoid Fibroma: A Rare Case Report and Review of Literature. ( 27833828 )
2016
27
Chondromyxoid Fibroma of Pelvis, Surgical Management of 8 Cases. ( 26058932 )
2015
28
Chondromyxoid fibroma of the frontal bone mimicking meningioma. ( 25748938 )
2015
29
Chondromyxoid fibroma of zygoma in an elderly patient: A rare presentation. ( 26981481 )
2015
30
Chondromyxoid Fibroma of the Sternum in a 63-Year-Old Woman. ( 26413029 )
2015
31
Surgical management of a giant sternal chondromyxoid fibroma: a case report. ( 26615403 )
2015
32
Extradural spinal chondromyxoid fibroma mimicking intradural mass lesion: MR and MR myelographic images. ( 26235465 )
2015
33
Chondromyxoid fibroma invasion of the transverse-sigmoid sinus junction causing posterior fossa hemorrhage. ( 26481053 )
2015
34
Maxillary osteosarcoma masquerading as chondromyxoid fibroma: report of a case. ( 25838677 )
2015
35
Chondromyxoid Fibroma of Two Cervical Vertebrae with Involvement of Surrounding Soft Tissue: Radiologic Diagnostic Dilemma. ( 26587204 )
2015
36
Chondromyxoid Fibroma: An Unusual Tumour at An Atypical Location. ( 26393192 )
2015
37
Surface chondromyxoid fibroma of the distal ulna: unusual tumor, site, and age. ( 24057439 )
2014
38
Chondromyxoid fibroma of zygoma: A rare case report. ( 24959045 )
2014
39
Chondromyxoid fibroma of the finger. ( 24883287 )
2014
40
Chondromyxoid Fibroma of the Mandible in an Adolescent: Case Report and Microsurgical Reconstructive Option. ( 24625223 )
2014
41
Chondromyxoid fibroma management: a single institution experience of 22 cases. ( 25217119 )
2014
42
Chondromyxoid fibroma; experience of 36 cases of an intriguing entity. ( 25989772 )
2014
43
GRM1 is upregulated through gene fusion and promoter swapping in chondromyxoid fibroma. ( 24658000 )
2014
44
Chondromyxoid fibroma of the mandible: Case report and review of the literature. ( 24987604 )
2014
45
A false positive finding on the PET of somatostatin receptor due to a chondromyxoid fibroma. ( 24140025 )
2014
46
Chondromyxoid fibroma of the calcaneus: two case reports and literature review. ( 23590809 )
2013
47
Epiphyseal chondromyxoid fibroma with prominent adipose tissue: an unusual radiologic and histologic presentation. ( 23630677 )
2013
48
Pseudotetraploid clone with structural chromosomal rearrangements in a chondromyxoid fibroma: a case report. ( 23282218 )
2013
49
Chondromyxoid fibroma of the second rib. ( 23845646 )
2013
50
Huge chondromyxoid fibroma of proximal third tibia masquerading as an aneurysmal bone cyst: A rare case report. ( 24455535 )
2013

Variations for Chondromyxoid Fibroma

Copy number variations for Chondromyxoid Fibroma from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 206032 6 135200000 139100000 Gain BCLAF1 Chondromyxoid Fibroma
2 215014 6 70000000 75900000 Gain COL12A1 Chondromyxoid Fibroma
3 215892 6 82700000 149100000 Deletion UTRN Chondromyxoid Fibroma

Expression for Chondromyxoid Fibroma

Search GEO for disease gene expression data for Chondromyxoid Fibroma.

Pathways for Chondromyxoid Fibroma

Pathways related to Chondromyxoid Fibroma according to GeneCards Suite gene sharing:

(show all 44)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.73 BCL2 CCND1 CDKN1A CDKN2A COL10A1 COL12A1
2
Show member pathways
12.82 BCL2 CCND1 CDKN1A CDKN2A TGFB1
3 12.75 BCL2 CCND1 CDKN1A CDKN2A FGFR3 TGFB1
4
Show member pathways
12.69 BCL2 CCND1 CDKN1A CDKN2A TGFB1
5
Show member pathways
12.63 BCL2 CCND1 CDKN1A CDKN2A FGFR3
6 12.46 CCND1 CDKN1A CDKN2A VIM
7 12.31 CCND1 CDKN1A CDKN2A TGFB1
8 12.31 CCND1 CDKN1A CDKN2A TGFB1
9
Show member pathways
12.29 CCND1 CDKN1A CDKN2A TGFB1
10 12.27 BCL2 CCND1 CDKN1A CDKN2A FGFR3 VIM
11
Show member pathways
12.24 BCL2 CCND1 CDKN1A CDKN2A SERPINE1
12
Show member pathways
12.16 BCL2 CCND1 CDKN1A FGFR3
13
Show member pathways
12.15 CCND1 CDKN1A CDKN2A TGFB1
14 12.07 BCL2 CCND1 CDKN1A FGFR3
15 12.03 CCND1 CDKN1A CDKN2A SERPINE1 TGFB1
16
Show member pathways
12.02 CCND1 CDKN1A GRM1 TGFB1
17 11.99 BCL2 CDKN1A S100A2 SERPINE1
18 11.98 BCL2 CDKN1A CDKN2A TGFB1
19 11.94 CCND1 SOX9 TGFB1 VIM
20 11.91 CCND1 CDKN1A CDKN2A
21 11.86 BCL2 CDKN1A SERPINE1
22 11.86 BCL2 CDKN1A PTH1R PTHLH
23 11.82 BCL2 CCND1 CDKN1A
24 11.81 BCL2 CCND1 SERPINE1 TGFB1
25 11.74 FGFR3 SOX9 VIM
26 11.73 BCL2 CCND1 CDKN1A
27 11.72 BCL2 CCND1 CDKN1A CDKN2A TGFB1
28 11.7 CDKN1A TGFB1 VIM
29 11.69 BCL2 CDKN1A CDKN2A
30 11.68 CDKN1A SERPINE1 TGFB1
31 11.68 ACTC1 DES VIM
32 11.62 BCL2 CDKN1A CDKN2A TGFB1
33 11.62 CCND1 CDKN1A CDKN2A FGFR3
34 11.61 BCL2 CCND1 CDKN1A TGFB1 VIM
35 11.58 BCL2 CCND1 CDKN1A
36 11.49 CCND1 CDKN1A TGFB1
37 11.46 BCL2 CDKN1A CDKN2A COL10A1 SERPINE1 TGFB1
38 11.38 BCL2 CCND1 CDKN1A CDKN2A
39 11.35 CCND1 PTH1R PTHLH
40
Show member pathways
11.01 BCL2 CDKN1A CDKN2A
41 10.95 TGFB1 VIM
42 10.91 COL10A1 FGFR3 PTH1R PTHLH SOX9 TGFB1
43 10.85 BCL2 COL10A1 COL12A1 DES FGFR3 TGFB1
44 10.83 BCL2 TGFB1

GO Terms for Chondromyxoid Fibroma

Cellular components related to Chondromyxoid Fibroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.77 BCL2 CCND1 CDKN1A CDKN2A DES FGFR3
2 collagen-containing extracellular matrix GO:0062023 8.92 COL10A1 COL12A1 SERPINE1 TGFB1

Biological processes related to Chondromyxoid Fibroma according to GeneCards Suite gene sharing:

(show all 28)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.93 ACTC1 CDKN2A SOX9 TGFB1 VIM
2 negative regulation of apoptotic process GO:0043066 9.91 ACTC1 BCL2 CDKN1A SOX9
3 response to drug GO:0042493 9.85 ACTC1 BCL2 CCND1 CDKN1A TGFB1
4 cytokine-mediated signaling pathway GO:0019221 9.8 BCL2 CCND1 CDKN1A TGFB1 VIM
5 positive regulation of cell proliferation GO:0008284 9.8 BCL2 CCND1 FGFR3 PTH1R PTHLH SOX9
6 cellular calcium ion homeostasis GO:0006874 9.79 BCL2 PTH1R TGFB1
7 female pregnancy GO:0007565 9.79 BCL2 PTHLH TGFB1
8 G1/S transition of mitotic cell cycle GO:0000082 9.77 CCND1 CDKN1A CDKN2A
9 response to organic substance GO:0010033 9.77 CCND1 CDKN1A TGFB1
10 ossification GO:0001503 9.76 BCL2 PTH1R SOX9
11 response to glucocorticoid GO:0051384 9.74 BCL2 CCND1 CDKN1A
12 negative regulation of cell growth GO:0030308 9.73 BCL2 CDKN1A CDKN2A TGFB1
13 animal organ regeneration GO:0031100 9.69 CCND1 CDKN1A TGFB1
14 bone mineralization GO:0030282 9.67 FGFR3 PTH1R PTHLH
15 muscle filament sliding GO:0030049 9.65 ACTC1 DES VIM
16 intermediate filament organization GO:0045109 9.64 DES VIM
17 negative regulation of chondrocyte differentiation GO:0032331 9.63 PTHLH SOX9
18 response to iron ion GO:0010039 9.63 BCL2 CCND1
19 negative regulation of phosphorylation GO:0042326 9.62 CDKN1A CDKN2A
20 negative regulation of epithelial cell differentiation GO:0030857 9.58 CCND1 SOX9
21 heart valve morphogenesis GO:0003179 9.56 SOX9 TGFB1
22 negative regulation of biomineral tissue development GO:0070168 9.55 SOX9 TGFB1
23 negative regulation of ossification GO:0030279 9.54 BCL2 SOX9 TGFB1
24 positive regulation of extracellular matrix assembly GO:1901203 9.52 SOX9 TGFB1
25 replicative senescence GO:0090399 9.5 CDKN1A CDKN2A SERPINE1
26 negative regulation of cell proliferation GO:0008285 9.5 BCL2 CDKN1A CDKN2A PTH1R PTHLH SOX9
27 chondrocyte differentiation GO:0002062 9.46 FGFR3 PTH1R SOX9 TGFB1
28 skeletal system development GO:0001501 9.02 COL10A1 FGFR3 PTH1R PTHLH SOX9

Molecular functions related to Chondromyxoid Fibroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.17 BCL2 DES FGFR3 S100A1 S100A2 TGFB1
2 cyclin-dependent protein serine/threonine kinase inhibitor activity GO:0004861 8.96 CDKN1A CDKN2A

Sources for Chondromyxoid Fibroma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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