MCID: CHN053
MIFTS: 44

Chondromyxoid Fibroma

Categories: Bone diseases, Rare diseases

Aliases & Classifications for Chondromyxoid Fibroma

MalaCards integrated aliases for Chondromyxoid Fibroma:

Name: Chondromyxoid Fibroma 59 73
Fibroma Chondromyxoid 55

Characteristics:

Orphanet epidemiological data:

59
chondromyxoid fibroma
Inheritance: Not applicable; Prevalence: <1/1000000 (Worldwide); Age of onset: Adult;

Classifications:

Orphanet: 59  
Rare bone diseases


External Ids:

Orphanet 59 ORPHA404507
UMLS via Orphanet 74 C0221290
ICD10 via Orphanet 34 D16.9
UMLS 73 C0221290

Summaries for Chondromyxoid Fibroma

MalaCards based summary : Chondromyxoid Fibroma, also known as fibroma chondromyxoid, is related to chondroblastoma and giant cell tumor, and has symptoms including pain An important gene associated with Chondromyxoid Fibroma is GRM1 (Glutamate Metabotropic Receptor 1), and among its related pathways/superpathways are ERK Signaling and Endometrial cancer. The drugs Denosumab and Bone Density Conservation Agents have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and skin, and related phenotypes are behavior/neurological and cellular

Wikipedia : 76 Chondromyxoid fibroma is a type of cartilaginous... more...

Related Diseases for Chondromyxoid Fibroma

Diseases related to Chondromyxoid Fibroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 110)
# Related Disease Score Top Affiliating Genes
1 chondroblastoma 30.9 PTH1R PTHLH SOX9
2 giant cell tumor 30.3 ACTC1 DES VIM
3 mesenchymal chondrosarcoma 30.2 DES SOX9 VIM
4 chordoma 29.9 CDKN2A DES S100A1 VIM
5 chondrosarcoma 10.6
6 aneurysmal bone cysts 10.5
7 ovarian fibrothecoma 10.2 ACTC1 DES
8 breast papillomatosis 10.2 CCND1 CDKN2A
9 fibroblastic rheumatism 10.2 ACTC1 DES
10 actinic cheilitis 10.2 CDKN1A FGFR3
11 botryoid rhabdomyosarcoma 10.2 ACTC1 DES
12 bizarre leiomyoma 10.2 ACTC1 CDKN2A
13 tonsil squamous cell carcinoma 10.2 CCND1 CDKN2A
14 lymphangiectasis 10.2 ACTC1 VIM
15 lymphoma, small cleaved-cell, diffuse 10.2 BCL2 CCND1
16 infantile digital fibromatosis 10.2 DES VIM
17 glomangiomyoma 10.2 ACTC1 VIM
18 plasma cell leukemia 10.2 CCND1 FGFR3
19 glomangioma 10.2 ACTC1 DES
20 intravascular papillary endothelial hyperplasia 10.2 ACTC1 VIM
21 lymphangiomatosis 10.2 DES VIM
22 dedifferentiated liposarcoma 10.2 ACTC1 CDKN2A DES
23 primitive neuroectodermal tumor of the cervix uteri 10.2 DES VIM
24 malignant peritoneal mesothelioma 10.2 CDKN2A VIM
25 retinal cancer 10.2 CCND1 CDKN1A CDKN2A
26 bowenoid papulosis 10.2 CCND1 CDKN2A
27 suppressor of tumorigenicity 3 10.2 BCL2 CDKN1A CDKN2A
28 ocular cancer 10.2 CCND1 CDKN1A CDKN2A
29 tooth ankylosis 10.2 PTH1R PTHLH
30 tongue cancer 10.2 CCND1 CDKN1A CDKN2A
31 clear cell chondrosarcoma 10.2 PTH1R PTHLH
32 skin carcinoma in situ 10.1 CCND1 CDKN2A
33 nervous system cancer 10.1 CCND1 CDKN1A CDKN2A
34 bladder disease 10.1 CCND1 CDKN2A FGFR3
35 endometrial squamous cell carcinoma 10.1 CCND1 CDKN2A
36 extramedullary plasmacytoma 10.1 BCL2 CCND1 CDKN1A
37 fasciitis 10.1 ACTC1 DES VIM
38 angiolipoma 10.1 ACTC1 DES VIM
39 cutaneous leiomyosarcoma 10.1 ACTC1 DES VIM
40 pleomorphic liposarcoma 10.1 CDKN2A DES VIM
41 liposarcoma 10.1 CDKN2A DES VIM
42 spindle cell lipoma 10.1 ACTC1 DES VIM
43 parachordoma 10.1 ACTC1 DES VIM
44 epulis 10.1 DES VIM
45 ossifying fibromyxoid tumor 10.1 ACTC1 DES VIM
46 epithelioid leiomyosarcoma 10.1 ACTC1 DES VIM
47 perivascular epithelioid cell tumor 10.1 ACTC1 DES VIM
48 cutaneous fibrous histiocytoma 10.1 ACTC1 DES VIM
49 fibrous histiocytoma 10.1 ACTC1 DES VIM
50 congenital fibrosarcoma 10.1 ACTC1 DES VIM

Graphical network of the top 20 diseases related to Chondromyxoid Fibroma:



Diseases related to Chondromyxoid Fibroma

Symptoms & Phenotypes for Chondromyxoid Fibroma

UMLS symptoms related to Chondromyxoid Fibroma:


pain

MGI Mouse Phenotypes related to Chondromyxoid Fibroma:

46 (show all 22)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.47 BCL2 CCND1 CDKN1A CDKN2A COL10A1 COL12A1
2 cellular MP:0005384 10.46 ACTC1 BCL2 CCND1 CDKN1A CDKN2A COL10A1
3 cardiovascular system MP:0005385 10.4 ACTC1 BCL2 CCND1 CDKN1A CDKN2A DES
4 homeostasis/metabolism MP:0005376 10.4 ACTC1 BCL2 CCND1 CDKN1A CDKN2A DES
5 growth/size/body region MP:0005378 10.39 ACTC1 BCL2 CCND1 CDKN1A CDKN2A COL10A1
6 mortality/aging MP:0010768 10.36 ACTC1 BCL2 CCND1 CDKN1A CDKN2A COL10A1
7 hematopoietic system MP:0005397 10.31 BCL2 CCND1 CDKN1A CDKN2A COL10A1 FGFR3
8 immune system MP:0005387 10.29 BCL2 CCND1 CDKN1A CDKN2A COL10A1 FGFR3
9 craniofacial MP:0005382 10.23 BCL2 CCND1 CDKN1A COL10A1 FGFR3 PTH1R
10 digestive/alimentary MP:0005381 10.22 BCL2 CCND1 CDKN1A CDKN2A FGFR3 PTH1R
11 endocrine/exocrine gland MP:0005379 10.21 BCL2 CCND1 CDKN1A CDKN2A COL10A1 PTH1R
12 integument MP:0010771 10.19 BCL2 CCND1 CDKN1A CDKN2A FGFR3 GRM1
13 muscle MP:0005369 10.17 ACTC1 BCL2 CDKN1A CDKN2A COL12A1 DES
14 adipose tissue MP:0005375 10.15 BCL2 CDKN1A GRM1 PTHLH SERPINE1 SOX9
15 nervous system MP:0003631 10.15 BCL2 CCND1 CDKN1A CDKN2A COL10A1 FGFR3
16 neoplasm MP:0002006 10.1 BCL2 CCND1 CDKN1A CDKN2A FGFR3 GRM1
17 limbs/digits/tail MP:0005371 10.02 CDKN1A COL10A1 COL12A1 FGFR3 PTH1R PTHLH
18 reproductive system MP:0005389 9.96 BCL2 CCND1 CDKN1A CDKN2A FGFR3 GRM1
19 renal/urinary system MP:0005367 9.92 BCL2 CDKN1A FGFR3 GRM1 PTHLH SERPINE1
20 respiratory system MP:0005388 9.9 CCND1 CDKN1A CDKN2A FGFR3 PTH1R PTHLH
21 skeleton MP:0005390 9.7 CCND1 CDKN1A CDKN2A COL10A1 COL12A1 FGFR3
22 vision/eye MP:0005391 9.36 BCL2 CCND1 CDKN1A CDKN2A FGFR3 GRM1

Drugs & Therapeutics for Chondromyxoid Fibroma

Drugs for Chondromyxoid Fibroma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Denosumab Approved Phase 2 615258-40-7
2 Bone Density Conservation Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Denosumab in Subjects With Giant Cell Rich Tumors of Bone Recruiting NCT03605199 Phase 2 Denosumab

Search NIH Clinical Center for Chondromyxoid Fibroma

Genetic Tests for Chondromyxoid Fibroma

Anatomical Context for Chondromyxoid Fibroma

MalaCards organs/tissues related to Chondromyxoid Fibroma:

41
Bone, Lung, Skin, Breast, Tonsil, Cervix, Smooth Muscle

Publications for Chondromyxoid Fibroma

Articles related to Chondromyxoid Fibroma:

(show top 50) (show all 313)
# Title Authors Year
1
Chondromyxoid Fibroma of the Metatarsal Bone: A Diagnosis Using Fine Needle Aspiration Biopsy. ( 29403178 )
2018
2
Chondromyxoid Fibroma Arising in Craniofacial Sites: A Clinicopathologic Analysis of 25 Cases. ( 29324473 )
2018
3
Benign Chondromyxoid Fibroma of the Iliac Crest. ( 29385939 )
2018
4
A case report on partial scapulectomy with glenoid preservation for Chondromyxoid fibroma of scapula. ( 29628714 )
2018
5
Treatment of cryotherapy and orthotopic transplantation following chondromyxoid fibroma of zygomatic bone: A case report. ( 30075574 )
2018
6
Huge chondromyxoid fibroma of the right iliac wing with tremendous soft tissue extensions. ( 30363225 )
2018
7
Surface-type chondromyxoid fibroma in an elderly patient: a case report and literature review. ( 30498967 )
2018
8
Radiological presentation of chondromyxoid fibroma in the sellar region: A CARE-compliant article and literature review. ( 29245307 )
2017
9
Primary Orbital Chondromyxoid Fibroma: A Rare Case. ( 28099230 )
2017
10
Chondromyxoid Fibroma of the Skull Base: Our Experience with an Elusive Disease. ( 28255973 )
2017
11
Long-lasting chondromyxoid fibroma of the zygoma: A rare case report and review of literature. ( 28852667 )
2017
12
Chondromyxoid fibroma of the distal fibula treated by percutaneous radiofrequency ablation. ( 28731366 )
2017
13
Chondromyxoid fibroma : a case report. ( 29877562 )
2017
14
An intracortical chondromyxoid fibroma in the diaphysis of the metatarsal. ( 28808739 )
2017
15
Chondromyxoid Fibroma of Radius: A Case Report. ( 27437232 )
2016
16
Acute cauda equina syndrome secondary to chondromyxoid fibroma of the lumbar spine. ( 26882861 )
2016
17
Chondromyxoid fibroma of the sacrum: A case report and literature review. ( 27274412 )
2016
18
Pediatric Chondromyxoid Fibroma-Like Osteosarcoma. ( 27935335 )
2016
19
Chondromyxoid Fibroma of the Skull Base and Calvarium: Surgical Management and Literature Review. ( 26929898 )
2016
20
Rare case of sacral mass due to chondromyxoid fibroma. ( 26961558 )
2016
21
Imaging features of chondromyxoid fibroma: report of 15 cases and literature review. ( 27226218 )
2016
22
Chondromyxoid fibroma of the pubic ramus: a case report and literature review. ( 26854059 )
2016
23
Chondromyxoid Fibroma: A Rare Case Report and Review of Literature. ( 27833828 )
2016
24
Chondromyxoid Fibroma of Pelvis, Surgical Management of 8 Cases. ( 26058932 )
2015
25
Chondromyxoid fibroma of the frontal bone mimicking meningioma. ( 25748938 )
2015
26
Chondromyxoid fibroma of zygoma in an elderly patient: A rare presentation. ( 26981481 )
2015
27
Chondromyxoid Fibroma of the Sternum in a 63-Year-Old Woman. ( 26413029 )
2015
28
Surgical management of a giant sternal chondromyxoid fibroma: a case report. ( 26615403 )
2015
29
Extradural spinal chondromyxoid fibroma mimicking intradural mass lesion: MR and MR myelographic images. ( 26235465 )
2015
30
Chondromyxoid fibroma invasion of the transverse-sigmoid sinus junction causing posterior fossa hemorrhage. ( 26481053 )
2015
31
Maxillary osteosarcoma masquerading as chondromyxoid fibroma: report of a case. ( 25838677 )
2015
32
Chondromyxoid Fibroma of Two Cervical Vertebrae with Involvement of Surrounding Soft Tissue: Radiologic Diagnostic Dilemma. ( 26587204 )
2015
33
Chondromyxoid Fibroma: An Unusual Tumour at An Atypical Location. ( 26393192 )
2015
34
Surface chondromyxoid fibroma of the distal ulna: unusual tumor, site, and age. ( 24057439 )
2014
35
Chondromyxoid fibroma of zygoma: A rare case report. ( 24959045 )
2014
36
Chondromyxoid fibroma of the finger. ( 24883287 )
2014
37
Chondromyxoid Fibroma of the Mandible in an Adolescent: Case Report and Microsurgical Reconstructive Option. ( 24625223 )
2014
38
Chondromyxoid fibroma management: a single institution experience of 22 cases. ( 25217119 )
2014
39
Chondromyxoid fibroma; experience of 36 cases of an intriguing entity. ( 25989772 )
2014
40
GRM1 is upregulated through gene fusion and promoter swapping in chondromyxoid fibroma. ( 24658000 )
2014
41
Chondromyxoid fibroma of the mandible: Case report and review of the literature. ( 24987604 )
2014
42
A false positive finding on the PET of somatostatin receptor due to a chondromyxoid fibroma. ( 24140025 )
2014
43
Chondromyxoid fibroma of the calcaneus: two case reports and literature review. ( 23590809 )
2013
44
Epiphyseal chondromyxoid fibroma with prominent adipose tissue: an unusual radiologic and histologic presentation. ( 23630677 )
2013
45
Pseudotetraploid clone with structural chromosomal rearrangements in a chondromyxoid fibroma: a case report. ( 23282218 )
2013
46
Chondromyxoid fibroma of the second rib. ( 23845646 )
2013
47
Huge chondromyxoid fibroma of proximal third tibia masquerading as an aneurysmal bone cyst: A rare case report. ( 24455535 )
2013
48
Chondromyxoid fibroma of calcaneus. ( 23337277 )
2013
49
Chondroblastoma and chondromyxoid fibroma. ( 23545728 )
2013
50
Intracortical chondromyxoid fibroma of the tibia. ( 21814765 )
2013

Variations for Chondromyxoid Fibroma

Copy number variations for Chondromyxoid Fibroma from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 206032 6 135200000 139100000 Gain BCLAF1 Chondromyxoid Fibroma
2 215014 6 70000000 75900000 Gain COL12A1 Chondromyxoid Fibroma
3 215892 6 82700000 149100000 Deletion UTRN Chondromyxoid Fibroma

Expression for Chondromyxoid Fibroma

Search GEO for disease gene expression data for Chondromyxoid Fibroma.

Pathways for Chondromyxoid Fibroma

Pathways related to Chondromyxoid Fibroma according to GeneCards Suite gene sharing:

(show all 45)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.72 BCL2 CCND1 CDKN1A CDKN2A COL10A1 COL12A1
2
Show member pathways
12.82 BCL2 CCND1 CDKN1A CDKN2A TGFB1
3 12.75 BCL2 CCND1 CDKN1A CDKN2A FGFR3 TGFB1
4
Show member pathways
12.71 BCL2 CCND1 CDKN1A CDKN2A FGFR3
5
Show member pathways
12.7 BCL2 CCND1 CDKN1A CDKN2A TGFB1
6 12.46 CCND1 CDKN1A CDKN2A VIM
7 12.38 CCND1 CDKN1A CDKN2A TGFB1
8 12.31 CCND1 CDKN1A CDKN2A TGFB1
9
Show member pathways
12.29 CCND1 CDKN1A CDKN2A TGFB1
10 12.27 BCL2 CCND1 CDKN1A CDKN2A FGFR3 VIM
11
Show member pathways
12.24 BCL2 CCND1 CDKN1A CDKN2A SERPINE1
12 12.23 BCL2 CCND1 CDKN1A VIM
13
Show member pathways
12.16 BCL2 CCND1 CDKN1A FGFR3
14
Show member pathways
12.15 CCND1 CDKN1A CDKN2A TGFB1
15 12.07 BCL2 CCND1 CDKN1A FGFR3
16 12.03 CCND1 CDKN1A CDKN2A SERPINE1 TGFB1
17
Show member pathways
12.02 CCND1 CDKN1A GRM1 TGFB1
18 11.99 BCL2 CDKN1A S100A2 SERPINE1
19 11.98 BCL2 CDKN1A CDKN2A TGFB1
20 11.94 CCND1 SOX9 TGFB1 VIM
21 11.91 CCND1 CDKN1A CDKN2A
22 11.86 BCL2 CDKN1A SERPINE1
23 11.86 BCL2 CDKN1A PTH1R PTHLH
24 11.83 BCL2 CCND1 CDKN1A
25 11.82 BCL2 CCND1 SERPINE1 TGFB1
26 11.74 FGFR3 SOX9 VIM
27 11.73 BCL2 CCND1 CDKN1A
28 11.72 BCL2 CCND1 CDKN1A CDKN2A TGFB1
29 11.71 CDKN1A TGFB1 VIM
30 11.7 BCL2 CDKN1A CDKN2A
31 11.69 CDKN1A SERPINE1 TGFB1
32 11.68 ACTC1 DES VIM
33 11.62 BCL2 CDKN1A CDKN2A TGFB1
34 11.62 CCND1 CDKN1A CDKN2A FGFR3
35 11.61 BCL2 CCND1 CDKN1A TGFB1 VIM
36 11.59 BCL2 CCND1 CDKN1A
37 11.49 CCND1 CDKN1A TGFB1
38 11.46 BCL2 CDKN1A CDKN2A COL10A1 SERPINE1 TGFB1
39 11.38 BCL2 CCND1 CDKN1A CDKN2A
40 11.35 CCND1 PTH1R PTHLH
41
Show member pathways
11.01 BCL2 CDKN1A CDKN2A
42 10.95 TGFB1 VIM
43 10.91 COL10A1 FGFR3 PTH1R PTHLH SOX9 TGFB1
44 10.85 BCL2 COL10A1 COL12A1 DES FGFR3 TGFB1
45 10.83 BCL2 TGFB1

GO Terms for Chondromyxoid Fibroma

Cellular components related to Chondromyxoid Fibroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.77 BCL2 CCND1 CDKN1A CDKN2A DES FGFR3
2 collagen-containing extracellular matrix GO:0062023 8.92 COL10A1 COL12A1 SERPINE1 TGFB1

Biological processes related to Chondromyxoid Fibroma according to GeneCards Suite gene sharing:

(show all 28)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.93 ACTC1 CDKN2A SOX9 TGFB1 VIM
2 response to drug GO:0042493 9.85 ACTC1 BCL2 CCND1 CDKN1A TGFB1
3 cytokine-mediated signaling pathway GO:0019221 9.8 BCL2 CCND1 CDKN1A TGFB1 VIM
4 positive regulation of cell proliferation GO:0008284 9.8 BCL2 CCND1 FGFR3 PTH1R PTHLH SOX9
5 cellular calcium ion homeostasis GO:0006874 9.79 BCL2 PTH1R TGFB1
6 female pregnancy GO:0007565 9.79 BCL2 PTHLH TGFB1
7 G1/S transition of mitotic cell cycle GO:0000082 9.77 CCND1 CDKN1A CDKN2A
8 response to organic substance GO:0010033 9.77 CCND1 CDKN1A TGFB1
9 ossification GO:0001503 9.76 BCL2 PTH1R SOX9
10 response to glucocorticoid GO:0051384 9.74 BCL2 CCND1 CDKN1A
11 negative regulation of cell growth GO:0030308 9.73 BCL2 CDKN1A CDKN2A TGFB1
12 animal organ regeneration GO:0031100 9.69 CCND1 CDKN1A TGFB1
13 bone mineralization GO:0030282 9.67 FGFR3 PTH1R PTHLH
14 muscle filament sliding GO:0030049 9.65 ACTC1 DES VIM
15 intermediate filament organization GO:0045109 9.64 DES VIM
16 negative regulation of chondrocyte differentiation GO:0032331 9.63 PTHLH SOX9
17 response to iron ion GO:0010039 9.63 BCL2 CCND1
18 negative regulation of phosphorylation GO:0042326 9.62 CDKN1A CDKN2A
19 negative regulation of epithelial cell differentiation GO:0030857 9.58 CCND1 SOX9
20 heart valve morphogenesis GO:0003179 9.56 SOX9 TGFB1
21 negative regulation of biomineral tissue development GO:0070168 9.55 SOX9 TGFB1
22 negative regulation of ossification GO:0030279 9.54 BCL2 SOX9 TGFB1
23 positive regulation of extracellular matrix assembly GO:1901203 9.52 SOX9 TGFB1
24 replicative senescence GO:0090399 9.5 CDKN1A CDKN2A SERPINE1
25 negative regulation of cell proliferation GO:0008285 9.5 BCL2 CDKN1A CDKN2A PTH1R PTHLH SOX9
26 chondrocyte differentiation GO:0002062 9.46 FGFR3 PTH1R SOX9 TGFB1
27 skeletal system development GO:0001501 9.1 COL10A1 COL12A1 FGFR3 PTH1R PTHLH SOX9
28 negative regulation of apoptotic process GO:0043066 10 ACTC1 BCL2 CDKN1A FGFR3 SOX9

Molecular functions related to Chondromyxoid Fibroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.17 BCL2 DES FGFR3 S100A1 S100A2 TGFB1
2 cyclin-dependent protein serine/threonine kinase inhibitor activity GO:0004861 8.96 CDKN1A CDKN2A

Sources for Chondromyxoid Fibroma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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