MCID: CHN012
MIFTS: 56

Chondrosarcoma

Categories: Genetic diseases, Rare diseases, Bone diseases, Cancer diseases

Aliases & Classifications for Chondrosarcoma

MalaCards integrated aliases for Chondrosarcoma:

Name: Chondrosarcoma 57 12 76 53 59 75 29 13 55 6 44 15 40 73
Primary Chondrosarcoma of the Bone 12
Chondrosarcoma of Bone 12
Chdsa 75

Characteristics:

Orphanet epidemiological data:

59
chondrosarcoma
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe),1-9/100000 (Europe); Age of onset: Adult; Age of death: adult,elderly;

OMIM:

57
Inheritance:
autosomal recessive


HPO:

32
chondrosarcoma:
Inheritance autosomal recessive inheritance


Classifications:

Orphanet: 59  
Rare bone diseases


External Ids:

OMIM 57 215300
Disease Ontology 12 DOID:3371
MeSH 44 D002813
NCIt 50 C2946 C7155
Orphanet 59 ORPHA55880
MESH via Orphanet 45 D002813
UMLS via Orphanet 74 C0008479
ICD10 via Orphanet 34 C49.9
MedGen 42 C0008479
SNOMED-CT via HPO 69 258211005

Summaries for Chondrosarcoma

NIH Rare Diseases : 53 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.Orpha Number: 55880Disease definitionChondrosarcoma is a malignant bone tumor arising from cartilaginous tissue, most frequently occuring at the ends of the femur and tibia, the proximal end of the humerus and the pelvis; and presenting with a palpable mass and progressive pain. Chondrosarcoma is usually slow growing at low histological grades and can be well managed by intralesional curettage or en-block wide resection.Visit the Orphanet disease page for more resources.

MalaCards based summary : Chondrosarcoma, also known as primary chondrosarcoma of the bone, is related to intracranial chondrosarcoma and myxoid chondrosarcoma. An important gene associated with Chondrosarcoma is EXT1 (Exostosin Glycosyltransferase 1), and among its related pathways/superpathways are Glucose / Energy Metabolism and Citrate cycle (TCA cycle). The drugs Doxorubicin and Ifosfamide have been mentioned in the context of this disorder. Affiliated tissues include bone, breast and lung, and related phenotypes are abnormality of the skeletal system and chondrosarcoma

UniProtKB/Swiss-Prot : 75 Chondrosarcoma: A malignant neoplasm derived from cartilage cells. Chondrosarcomas range from slow-growing non-metastasizing lesions to highly aggressive metastasizing sarcomas.

Disease Ontology : 12 A connective tissue cancer that has material basis in cells derived from transformed cells that produce cartilage.

Wikipedia : 76 Chondrosarcoma is a cancer composed of cells derived from transformed cells that produce cartilage.... more...

Description from OMIM: 215300

Related Diseases for Chondrosarcoma

Diseases in the Chondrosarcoma family:

Localized Chondrosarcoma

Diseases related to Chondrosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 189)
# Related Disease Score Top Affiliating Genes
1 intracranial chondrosarcoma 34.3 IDH1 IDH2
2 myxoid chondrosarcoma 34.1 EWSR1 MTAP NR4A3 TAF15
3 extraosseous chondrosarcoma 33.5 ENO2 EWSR1 TAF15 TFG
4 chondrosarcoma, extraskeletal myxoid 33.5 ENO2 EWSR1 NR4A3 TAF15 TFG
5 clear cell chondrosarcoma 33.4 EXT2 PTHLH SPARC
6 periosteal chondrosarcoma 33.1 EXT1 IDH1 IDH2 NCOA2 PTHLH
7 exostoses, multiple, type i 32.7 EXT1 EXT2
8 multiple enchondromatosis, maffucci type 32.6 EXT1 EXT2 IDH1 IDH2
9 enchondroma 31.9 IDH1 IDH2
10 osteochondroma 31.1 EXT1 EXT2 PTHLH
11 chondroblastic osteosarcoma 30.9 IDH1 IDH2
12 enchondromatosis, multiple, ollier type 30.0 EXT1 EXT2 IDH1 IDH2 PTHLH
13 undifferentiated pleomorphic sarcoma 29.7 IDH1 IDH2
14 ewing sarcoma 29.6 ENO2 EWSR1 MMP1 NR4A3 TAF15
15 mesenchymal chondrosarcoma 12.4
16 bone chondrosarcoma 12.2
17 adult mesenchymal chondrosarcoma 12.1
18 adult myxoid chondrosarcoma 12.1
19 extraskeletal mesenchymal chondrosarcoma 12.1
20 localized chondrosarcoma 12.0
21 juxtacortical chondrosarcoma 12.0
22 pediatric mesenchymal chondrosarcoma 11.8
23 pediatric myxoid chondrosarcoma 11.8
24 adult extraosseous chondrosarcoma 11.8
25 chondroid chordoma 11.2
26 dysplasia epiphysealis hemimelica 11.0 EXT1 EXT2
27 interval angle-closure glaucoma 10.9 IDH1 IDH2
28 adult oligodendroglioma 10.9 IDH1 IDH2
29 exostoses, multiple, type ii 10.9
30 bone cancer 10.9
31 bizzare parosteal osteochondromatous proliferation 10.9
32 hereditary multiple osteochondromas 10.8 EXT1 EXT2
33 cytogenetically normal acute myeloid leukemia 10.8 IDH1 IDH2
34 intraductal papilloma 10.7 IDH1 IDH2
35 pilocytic astrocytoma of cerebellum 10.7 IDH1 IDH2
36 spindle cell hemangioma 10.6 IDH1 IDH2
37 glioma susceptibility 1 10.6 IDH1 IDH2
38 adult astrocytic tumour 10.6 IDH1 IDH2 MMP1
39 small cell osteogenic sarcoma 10.5 ENO2 EWSR1
40 juxtacortical chondroma 10.5 EWSR1 EXT1 PTHLH
41 orbital cancer 10.5 ENO2 EWSR1
42 sinonasal undifferentiated carcinoma 10.5 ENO2 IDH2
43 askin's tumor 10.5 ENO2 EWSR1
44 bone deterioration disease 10.4 MMP1 MMP13 SOX9
45 kidney rhabdoid cancer 10.4 ENO2 EWSR1
46 cauda equina neoplasm 10.4 ENO2 EWSR1
47 connective tissue cancer 10.4 ENO2 EWSR1 EXT1
48 chordoma 10.3
49 periostitis 10.3
50 tooth ankylosis 10.3 PTHLH SPARC

Graphical network of the top 20 diseases related to Chondrosarcoma:



Diseases related to Chondrosarcoma

Symptoms & Phenotypes for Chondrosarcoma

Symptoms via clinical synopsis from OMIM:

57
Skel:
chondrosarcoma


Clinical features from OMIM:

215300

Human phenotypes related to Chondrosarcoma:

32
# Description HPO Frequency HPO Source Accession
1 abnormality of the skeletal system 32 HP:0000924
2 chondrosarcoma 32 HP:0006765

Drugs & Therapeutics for Chondrosarcoma

Drugs for Chondrosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 152)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxorubicin Approved, Investigational Phase 3,Phase 2,Phase 1 23214-92-8 31703
2
Ifosfamide Approved Phase 3,Phase 2 3778-73-2 3690
3
Mechlorethamine Approved, Investigational Phase 3,Phase 2 51-75-2 4033
4
Cyclophosphamide Approved, Investigational Phase 2, Phase 3,Not Applicable 50-18-0, 6055-19-2 2907
5
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
6
Cyproheptadine Approved Phase 3 129-03-3 2913
7
Histamine Approved, Investigational Phase 3 75614-87-8, 51-45-6 774
8
Trabectedin Approved, Investigational Phase 2, Phase 3 114899-77-3 108150
9
Doxil Approved June 1999 Phase 3,Phase 2,Phase 1 31703
10 Pancreatic Polypeptide Investigational Phase 3 59763-91-6
11 Alkylating Agents Phase 3,Phase 2,Not Applicable
12 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1,Not Applicable
13 Antibiotics, Antitubercular Phase 3,Phase 2,Phase 1
14 Antineoplastic Agents, Alkylating Phase 3,Phase 2,Not Applicable
15
Isophosphamide mustard Phase 3,Phase 2 0
16 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1
17 Analgesics Phase 3,Phase 1,Phase 2,Not Applicable
18 Liver Extracts Phase 3,Phase 2,Phase 1,Not Applicable
19 Peripheral Nervous System Agents Phase 3,Phase 1,Phase 2,Not Applicable
20 Adjuvants, Anesthesia Phase 3
21 Analgesics, Opioid Phase 3
22 Anesthetics Phase 3
23 Anesthetics, General Phase 3
24 Anesthetics, Intravenous Phase 3
25 Central Nervous System Depressants Phase 3
26 Narcotics Phase 3
27 Gastrointestinal Agents Phase 3,Phase 1,Phase 2
28 Anti-Allergic Agents Phase 3
29 Antipruritics Phase 3
30 Dermatologic Agents Phase 3
31 Histamine Antagonists Phase 3
32 Histamine H1 Antagonists Phase 3
33
Histamine Phosphate Phase 3 51-74-1 65513
34 Neurotransmitter Agents Phase 3
35 Serotonin Agents Phase 3
36 Serotonin Antagonists Phase 3
37 Cola Nutraceutical Phase 3,Phase 1,Not Applicable
38
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
39
Everolimus Approved Phase 2,Phase 1 159351-69-6 6442177
40
Miconazole Approved, Investigational, Vet_approved Phase 2,Phase 1 22916-47-8 4189
41
Sirolimus Approved, Investigational Phase 2,Phase 1 53123-88-9 5284616 6436030 46835353
42
chloroquine Approved, Investigational, Vet_approved Phase 1, Phase 2 54-05-7 2719
43
Metformin Approved Phase 1, Phase 2 657-24-9 14219 4091
44
Dacarbazine Approved, Investigational Phase 2 4342-03-4 5351166
45
Temozolomide Approved, Investigational Phase 2 85622-93-1 5394
46
Pemetrexed Approved, Investigational Phase 2 150399-23-8, 137281-23-3 446556 60843
47
Docetaxel Approved, Investigational Phase 2,Phase 1 114977-28-5 148124
48
Gemcitabine Approved Phase 2,Phase 1 95058-81-4 60750
49
Lenograstim Approved, Investigational Phase 2,Phase 1 135968-09-1
50
Angiotensin II Approved, Investigational Phase 2 68521-88-0, 4474-91-3, 11128-99-7 172198 65143

Interventional clinical trials:

(show top 50) (show all 83)
# Name Status NCT ID Phase Drugs
1 Stereotactic Body Radiotherapy for Head and Neck Tumors Unknown status NCT01344356 Phase 4
2 Ifosfamide and Doxorubicin, Radiation Therapy, and/or Surgery in Treating Young Patients With Localized Soft Tissue Sarcoma Unknown status NCT00334854 Phase 3 doxorubicin hydrochloride;ifosfamide
3 Observation, Radiation Therapy, Combination Chemotherapy, and/or Surgery in Treating Young Patients With Soft Tissue Sarcoma Completed NCT00346164 Phase 3 doxorubicin hydrochloride;ifosfamide
4 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
5 Trial of Proton Versus Carbon Ion Radiation Therapy in Patients With Low and Inter-mediate Grade Chondrosarcoma of the Skull Base Recruiting NCT01182753 Phase 3
6 Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery Recruiting NCT02180867 Phase 2, Phase 3 Doxorubicin Hydrochloride;Ifosfamide;Pazopanib Hydrochloride
7 Randomised Trial of Volume of Post-operative Radiotherapy Given to Adult Patients With eXtremity Soft Tissue Sarcoma Active, not recruiting NCT00423618 Phase 3
8 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
9 Doxorubicin Hydrochloride or Trabectedin in Treating Patients With Previously Untreated Advanced or Metastatic Soft Tissue Sarcoma Terminated NCT01189253 Phase 2, Phase 3 doxorubicin hydrochloride;trabectedin
10 Proton Radiation for Chordomas and Chondrosarcomas Unknown status NCT01449149 Phase 1, Phase 2
11 Trial of Pazopanib in Patients With Solitary Fibrous Tumor and Extraskeletal Myxoid Chondrosarcoma Unknown status NCT02066285 Phase 2 Pazopanib
12 Sirolimus and Cyclophosphamide in Metastatic or Unresectable Myxoid Liposarcoma and Chondrosarcoma Unknown status NCT02821507 Phase 2 sirolimus and cyclophosphamide
13 Metformin And Chloroquine in IDH1/2-mutated Solid Tumors Unknown status NCT02496741 Phase 1, Phase 2 Metformin and chloroquine combination
14 Trial of Nilotinib and Adriamycin as Treatment in Liposarcomas and Leiomyosarcomas of Retroperitoneum Unknown status NCT02587169 Phase 1, Phase 2 Nilotinib-adriamycin
15 Temozolomide in Treating Patients With Advanced Soft Tissue Sarcoma Unknown status NCT00003718 Phase 2 temozolomide
16 Study of Pazopanib in the Treatment of Surgically Unresectable or Metastatic Chondrosarcoma Completed NCT01330966 Phase 2 pazopanib
17 A Safety and Efficacy Study of Patients With Metastatic or Locally Advanced (Unresectable) Chondrosarcoma Completed NCT01310816 Phase 2 IPI-926;Placebo Arm
18 S0344 Intralesional Resection in Treating Patients With Chondrosarcoma of the Bone Completed NCT00096213 Phase 2
19 S0423 Pemetrexed Disodium in Treating Patients With Recurrent and Unresectable or Metastatic Chondrosarcoma Completed NCT00107419 Phase 2 pemetrexed disodium
20 Charged Particle RT for Chordomas and Chondrosarcomas of the Base of Skull or Cervical Spine Completed NCT00592748 Phase 1, Phase 2
21 Gemcitabine and Docetaxel in Treating Patients With Recurrent Osteosarcoma (Closed to Accrual as of 12/21/06) or Ewing's Sarcoma or Unresectable or Locally Recurrent Chondrosarcoma Completed NCT00073983 Phase 2 docetaxel;gemcitabine hydrochloride
22 A Trial of Perifosine in Patients With Chemo-Insensitive Sarcomas Completed NCT00401388 Phase 2 Perifosine
23 A Study of R1507 in Participants With Recurrent or Refractory Sarcoma Completed NCT00642941 Phase 2 RG1507
24 Linsitinib in Treating Patients With Gastrointestinal Stromal Tumors Completed NCT01560260 Phase 2 Linsitinib
25 Study of Orally Administered AG-221 in Subjects With Advanced Solid Tumors, Including Glioma, and With Angioimmunoblastic T-cell Lymphoma, With an IDH2 Mutation Subjects With Advanced Solid Tumors, Including Glioma, and With Angioimmunoblastic T-cell Lymp Completed NCT02273739 Phase 1, Phase 2 AG-221
26 Vismodegib and Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Advanced or Metastatic Sarcoma Completed NCT01154452 Phase 1, Phase 2 Gamma-Secretase Inhibitor RO4929097;Vismodegib
27 Therapeutic Angiotensin-(1-7) in Treating Patients With Metastatic Sarcoma That Cannot Be Removed By Surgery Completed NCT01553539 Phase 2 therapeutic angiotensin-(1-7)
28 Depsipeptide (Romidepsin) in Treating Patients With Metastatic or Unresectable Soft Tissue Sarcoma Completed NCT00112463 Phase 2 romidepsin
29 Sunitinib in Treating Patients With Metastatic, Locally Advanced, or Locally Recurrent Sarcomas Completed NCT00474994 Phase 2 sunitinib malate
30 Combination Chemotherapy in Treating Children With Metastatic Rhabdomyosarcoma or Other Malignant Mesenchymal Tumors Completed NCT00025441 Phase 2 carboplatin;cyclophosphamide;doxorubicin hydrochloride;epirubicin hydrochloride;etoposide;ifosfamide;vincristine sulfate
31 Combination Chemotherapy Followed by Bone Marrow Transplantation in Treating Patients With Rare Cancer Completed NCT00002515 Phase 2 carboplatin;thiotepa;topotecan hydrochloride
32 Radiation Therapy in Treating Patients With Newly Diagnosed Brain Metastases From Kidney Cancer, Melanoma, or Sarcoma Completed NCT00003308 Phase 2
33 High-dose ICE With Amifostine Completed NCT00003657 Phase 2 Amifostine;Carboplatin;Etoposide;Ifosfamide
34 Safety and Efficacy Study of Torisel and Liposomal Doxorubicin for Patients With Recurrent Sarcoma Completed NCT00949325 Phase 1, Phase 2 temsirolimus (Torisel) plus liposomal doxorubicin (Doxil)
35 A Study of CDX-1401 in Patients With Malignancies Known to Express NY-ESO-1 Completed NCT00948961 Phase 1, Phase 2
36 Phase II Study of Imatinib Mesylate in Patients With Life Threatening Malignant Rare Diseases Completed NCT00154388 Phase 2 Imatinib mesylate
37 Alanosine in Treating Patients With Cancer Completed NCT00062283 Phase 2 L-alanosine
38 Nivolumab (Opdivo®) Plus ABI-009 (Nab-rapamycin) for Advanced Sarcoma Recruiting NCT03190174 Phase 1, Phase 2 Nab-Rapamycin
39 A Phase II Study Evaluating Efficacy and Safety of Regorafenib in Patients With Metastatic Bone Sarcomas Recruiting NCT02389244 Phase 2 Regorafenib;Placebo
40 Proton or Photon RT for Retroperitoneal Sarcomas Recruiting NCT01659203 Phase 1, Phase 2
41 A Phase II, Multicenter Study of the EZH2 Inhibitor Tazemetostat in Adult Subjects With INI1-Negative Tumors or Relapsed/Refractory Synovial Sarcoma Recruiting NCT02601950 Phase 2 Tazemetostat
42 SARC028: A Phase II Study of the Anti-PD1 Antibody Pembrolizumab (MK-3475) in Patients With Advanced Sarcomas Recruiting NCT02301039 Phase 2 Pembrolizumab
43 Gemcitabine Hydrochloride With or Without Pazopanib Hydrochloride in Treating Patients With Refractory Soft Tissue Sarcoma Recruiting NCT01532687 Phase 2 Gemcitabine Hydrochloride;Pazopanib Hydrochloride
44 Autologous Dendritic Cell Vaccine Loaded With Allogeneic Tumor Lysate Expression of Cancer Testis Antigens in Patients With Soft Tissue Sarcoma Recruiting NCT01883518 Phase 1, Phase 2
45 Proton Beam Therapy for Chondrosarcoma Active, not recruiting NCT00496522 Phase 2
46 Imatinib in Patients With Desmoid Tumor and Chondrosarcoma Active, not recruiting NCT00928525 Phase 2 Imatinib Mesylate
47 Vismodegib in Treating Patients With Advanced Chondrosarcomas Active, not recruiting NCT01267955 Phase 2 Vismodegib
48 Trial of Dasatinib in Advanced Sarcomas Active, not recruiting NCT00464620 Phase 2 Dasatinib
49 Iodine I 131 Monoclonal Antibody 3F8 in Treating Patients With Central Nervous System Cancer or Leptomeningeal Cancer Active, not recruiting NCT00445965 Phase 2
50 Image-Guided Radiation Therapy in Treating Patients With Primary Soft Tissue Sarcoma of the Shoulder, Arm, Hip, or Leg Active, not recruiting NCT00589121 Phase 2 Chemotherapy

Search NIH Clinical Center for Chondrosarcoma

Cochrane evidence based reviews: chondrosarcoma

Genetic Tests for Chondrosarcoma

Genetic tests related to Chondrosarcoma:

# Genetic test Affiliating Genes
1 Chondrosarcoma 29 EXT1

Anatomical Context for Chondrosarcoma

MalaCards organs/tissues related to Chondrosarcoma:

41
Bone, Breast, Lung, Kidney, Brain, Liver, Endothelial

Publications for Chondrosarcoma

Articles related to Chondrosarcoma:

(show top 50) (show all 1724)
# Title Authors Year
1
Laryngeal Chondrosarcoma: A rare cause of critical upper airway obstruction. ( 29869857 )
2018
2
Secondary Chondrosarcoma Presenting with Symptoms Similar to Thoracic Outlet Syndrome. ( 29721343 )
2018
3
The role of surgical margins in chondrosarcoma. ( 29929901 )
2018
4
Sellar chondrosarcoma presenting with amenorrhea: A case report. ( 29979394 )
2018
5
Periosteal mesenchymal chondrosarcoma of the tibia. ( 29397433 )
2018
6
Dedifferentiated Chondrosarcoma Demonstrating Osteosarcomatous Differentiation. ( 29902785 )
2018
7
Tracheal chondrosarcoma and surgical management. ( 29860896 )
2018
8
Molecular and Clinicopathologic Heterogeneity of Intracranial Tumors Mimicking Extraskeletal Myxoid Chondrosarcoma. ( 29924341 )
2018
9
Mesenchymal chondrosarcoma of the orbit: Imaging features of CT and MRI. ( 29975155 )
2018
10
Chondrosarcoma third metacarpal: Diagnosis and management options. ( 29893351 )
2018
11
Primary extraskeletal mesenchymal chondrosarcoma arising from the iliac vein. ( 29332118 )
2018
12
Mesenchymal Chondrosarcoma of the Lacrimal Gland. ( 29342030 )
2018
13
Extraskeletal Myxoid Chondrosarcoma: A Comparative Study of Imaging and Pathology. ( 29977924 )
2018
14
Mosaic-pattern dedifferentiation in liposarcoma and chondrosarcoma: imaging features of an uncommon form of dedifferentiation. ( 29362843 )
2018
15
Falcine Myxoid Chondrosarcoma: A Rare Aggressive Case. ( 29492125 )
2018
16
Metastasis from Intracranial Mesenchymal Chondrosarcoma: Report of a Rare Case. ( 29972855 )
2018
17
How to Diagnose Enchondroma, Bone Infarct, and Chondrosarcoma. ( 29724496 )
2018
18
Extended endoscopic endonasal surgery for clival chordoma and chondrosarcoma: Our experience in 14 cases. ( 29691145 )
2018
19
Expression of PD-L1/PD-L2 is associated with high proliferation index of Ki-67 but not with TP53 overexpression in chondrosarcoma. ( 29862874 )
2018
20
Huge myxoid chondrosarcoma expanded into the thoracic cavity with spinal involvement. ( 29974237 )
2018
21
Intracranial chondrosarcoma: Series of three cases with varied and unusual presentations. ( 29676384 )
2018
22
Clear Cell Chondrosarcoma With Chondroblastoma-Like Features: A Case for Team Diagnosis. ( 29774790 )
2018
23
Anti-Hu-Associated Autoimmune Limbic Encephalitis in a Patient with PD-1 Inhibitor-Responsive Myxoid Chondrosarcoma. ( 29158368 )
2018
24
Mesenchymal Chondrosarcoma of the Orbit Attached to the Optic Nerve. ( 29863559 )
2018
25
18F-FDG PET/CT in Diagnostic and Prognostic Evaluation of Patients With Suspected Recurrence of Chondrosarcoma. ( 29261626 )
2018
26
Personalised 3D-printed model of a chest-wall chondrosarcoma to enhance patient understanding of complex cardiothoracic surgery. ( 29804079 )
2018
27
Chondrosarcoma of the Osseous Spine Treated by Surgery With or Without Radiotherapy: A Propensity Score Matched and Grade/Stage-stratified Study. ( 29864077 )
2018
28
Primary mesenchymal chondrosarcoma of the orbit: Histopathological report of 3 pediatric cases. ( 29755276 )
2018
29
Synergistic anti-proliferative effects of mTOR and MEK inhibitors in high-grade chondrosarcoma cell line OUMS-27. ( 29397960 )
2018
30
Intracranial Mesenchymal Chondrosarcoma: Report of 16 Cases. ( 29783007 )
2018
31
Diagnostic Role of Intraoperative Imprint Cytology in an Unusual Case of Chondrosarcoma Presenting as Acute Onset Stridor. ( 29403179 )
2018
32
Chondrosarcoma: A Rare Misfortune in Aging Human Cartilage? The Role of Stem and Progenitor Cells in Proliferation, Malignant Degeneration and Therapeutic Resistance. ( 29361725 )
2018
33
Tumour Volume and Dose Influence Outcome after Surgery and High-dose Photon Radiotherapy for Chordoma and Chondrosarcoma of the Skull Base and Spine. ( 29402600 )
2018
34
Identification of an Actionable Mutation of KIT in a Case of Extraskeletal Myxoid Chondrosarcoma. ( 29937513 )
2018
35
Marginal resection in a case of juxtacortical chondrosarcoma of the mandible. ( 29937670 )
2018
36
18F-FDG PET/CT Findings of Mesenchymal Chondrosarcoma of the Orbit. ( 29215408 )
2018
37
Primary mesenchymal chondrosarcoma of the kidney: A case report and review of literature. ( 29893343 )
2018
38
Minute Mesenchymal Chondrosarcoma within Osteochondroma: An Unexpected Diagnosis Confirmed by HEY1-NCOA2 Fusion. ( 29596896 )
2018
39
Analysis of IL6-protein complexes in chondrosarcoma. ( 29399342 )
2018
40
Revision strategy and follow-up for implant failure in a case of combined anterior and posterior reconstruction after three-level en bloc vertebral body replacement and replacement of the aorta for chondrosarcoma of the thoracic spine. ( 29955999 )
2018
41
Mesenchymal Chondrosarcoma: a Review with Emphasis on its Fusion-Driven Biology. ( 29582189 )
2018
42
Osteosarcoma, Chondrosarcoma, and Chordoma. ( 29220289 )
2018
43
Expression of MMP-9 decreases metastatic potential of Chondrosarcoma: an immunohistochemical study. ( 29316907 )
2018
44
Response to: Periosteal mesenchymal chondrosarcoma of the tibia. ( 29473108 )
2018
45
INSM1 expression and its diagnostic significance in extraskeletal myxoid chondrosarcoma. ( 29327709 )
2018
46
Extraskeletal Myxoid Chondrosarcoma of Nasopharynx: An Oncologic Entity Rarely Reported. ( 29657686 )
2018
47
Primary pulmonary myxoid sarcoma, a potential mimic of metastatic extraskeletal myxoid chondrosarcoma. ( 29110880 )
2017
48
Chondrosarcoma in Metachondromatosis: A Rare Case Report. ( 29373887 )
2017
49
Chondrosarcoma of the patella: A case report. ( 28906396 )
2017
50
Puerarin induces cell apoptosis in human chondrosarcoma cell line SW1353 via inhibition of the PI3K/Akt signaling pathway. ( 29113186 )
2017

Variations for Chondrosarcoma

UniProtKB/Swiss-Prot genetic disease variations for Chondrosarcoma:

75
# Symbol AA change Variation ID SNP ID
1 EXT1 p.Asn316Ser VAR_012820

ClinVar genetic disease variations for Chondrosarcoma:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 EXT1 NM_000127.2(EXT1): c.528_535delCAAAGTGC (p.Lys177Glufs) deletion Pathogenic rs587776540 GRCh37 Chromosome 8, 119122751: 119122758
2 EXT1 NM_000127.2(EXT1): c.528_535delCAAAGTGC (p.Lys177Glufs) deletion Pathogenic rs587776540 GRCh38 Chromosome 8, 118110512: 118110519

Cosmic variations for Chondrosarcoma:

9
(show all 12)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM6940728 PALB2 bone,pelvis,chondrosarcoma,dedifferentiated c.2177C>T p.P726L 16:23629977-23629977 13
2 COSM28747 IDH1 bone,femur,chondrosarcoma,conventional c.394C>T p.R132C 2:208248389-208248389 13
3 COSM28750 IDH1 bone,femur,chondrosarcoma,conventional c.395G>T p.R132L 2:208248388-208248388 13
4 COSM28748 IDH1 bone,humerus,chondrosarcoma,conventional c.394C>A p.R132S 2:208248389-208248389 13
5 COSM28749 IDH1 bone,femur,chondrosarcoma,conventional c.394C>G p.R132G 2:208248389-208248389 13
6 COSM28746 IDH1 bone,femur,chondrosarcoma,conventional c.395G>A p.R132H 2:208248388-208248388 13
7 COSM480 HRAS bone,femur,chondrosarcoma,conventional c.34G>A p.G12S 11:534289-534289 13
8 COSM485 HRAS bone,femur,chondrosarcoma,conventional c.35G>C p.G12A 11:534288-534288 13
9 COSM6942013 CENPA bone,pelvis,chondrosarcoma,dedifferentiated c.199T>C p.F67L 2:26792229-26792229 13
10 COSM1732355 H3F3A soft tissue,bone,sarcoma,NS c.103G>T p.G35W 1:226064454-226064454 7
11 COSM3908208 GNAQ soft tissue,bone,sarcoma,NS c.442C>T p.R148* 9:77815650-77815650 7
12 COSM3908209 soft tissue,bone,sarcoma,NS c.355C>T p.R119* 9:77815650-77815650 7

Copy number variations for Chondrosarcoma from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 110025 17 31160600 31198351 Translate TAF15 Chondrosarcoma

Expression for Chondrosarcoma

Search GEO for disease gene expression data for Chondrosarcoma.

Pathways for Chondrosarcoma

GO Terms for Chondrosarcoma

Biological processes related to Chondrosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cartilage development GO:0051216 9.58 CNMD MMP13 SOX9
2 skeletal system development GO:0001501 9.56 CNMD EXT1 PTHLH SOX9
3 2-oxoglutarate metabolic process GO:0006103 9.48 IDH1 IDH2
4 negative regulation of chondrocyte differentiation GO:0032331 9.46 PTHLH SOX9
5 heparan sulfate proteoglycan biosynthetic process GO:0015012 9.43 EXT1 EXT2
6 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process GO:0015014 9.37 EXT1 EXT2
7 isocitrate metabolic process GO:0006102 9.32 IDH1 IDH2
8 glyoxylate cycle GO:0006097 9.16 IDH1 IDH2
9 cellular polysaccharide biosynthetic process GO:0033692 8.96 EXT1 EXT2
10 ossification GO:0001503 8.92 EXT1 EXT2 SOX9 SPARC

Molecular functions related to Chondrosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heparan sulfate N-acetylglucosaminyltransferase activity GO:0042328 9.32 EXT1 EXT2
2 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity GO:0050508 9.26 EXT1 EXT2
3 isocitrate dehydrogenase activity GO:0004448 9.16 IDH1 IDH2
4 isocitrate dehydrogenase (NADP+) activity GO:0004450 8.96 IDH1 IDH2
5 N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity GO:0050509 8.62 EXT1 EXT2
6 metal ion binding GO:0046872 10.11 ENO2 EWSR1 EXT1 EXT2 IDH1 IDH2

Sources for Chondrosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....