EMC
MCID: CHN056
MIFTS: 47

Chondrosarcoma, Extraskeletal Myxoid (EMC)

Categories: Bone diseases, Cancer diseases, Genetic diseases, Rare diseases

Aliases & Classifications for Chondrosarcoma, Extraskeletal Myxoid

MalaCards integrated aliases for Chondrosarcoma, Extraskeletal Myxoid:

Name: Chondrosarcoma, Extraskeletal Myxoid 58 13 45
Extraskeletal Myxoid Chondrosarcoma 12 60 38 15 74
Myxoid Extraosseous Chondrosarcoma 12
Emc 58

Characteristics:

Orphanet epidemiological data:

60
extraskeletal myxoid chondrosarcoma
Inheritance: Not applicable; Age of onset: Adult; Age of death: adult;

HPO:

33
chondrosarcoma, extraskeletal myxoid:
Inheritance somatic mutation


Classifications:



External Ids:

Disease Ontology 12 DOID:6496
OMIM 58 612237
KEGG 38 H00053
MeSH 45 C563195
NCIt 51 C27502
ICD10 via Orphanet 35 C49.9
UMLS via Orphanet 75 C1275278
Orphanet 60 ORPHA209916
MedGen 43 C1275278
SNOMED-CT via HPO 70 124975008 14990007 443520009
UMLS 74 C1275278

Summaries for Chondrosarcoma, Extraskeletal Myxoid

OMIM : 58 Extraskeletal myxoid chondrosarcoma is a rare soft tissue neoplasm of chondroblastic origin. The tumors are most commonly found in middle-aged and elderly individuals, are more common among men, and are often detected as deep-seated lesions in the extremities. Despite their relatively low-grade malignancy, recurrence and metastasis may appear many years after the initial diagnosis. Histologic tissue section examination reveals a mixture of cellular and myxoid stromal components (Panagopoulos et al., 2002). (612237)

MalaCards based summary : Chondrosarcoma, Extraskeletal Myxoid, also known as extraskeletal myxoid chondrosarcoma, is related to epithelial-myoepithelial carcinoma and myxoid chondrosarcoma. An important gene associated with Chondrosarcoma, Extraskeletal Myxoid is NR4A3 (Nuclear Receptor Subfamily 4 Group A Member 3), and among its related pathways/superpathways are Transcriptional misregulation in cancer and Chromatin Regulation / Acetylation. The drugs Ifosfamide and Mechlorethamine have been mentioned in the context of this disorder. Affiliated tissues include lung, bone and heart, and related phenotype is chondrosarcoma.

Disease Ontology : 12 An extraosseous chondrosarcoma that has material basis in cells derived from transformed cells that produce cartilage and is characterized by a marked abundance of extracellular mucoid (myxoid) matrix.

Wikipedia : 77 Extraskeletal myxoid chondrosarcoma (EMC) is a rare low-grade malignant mesenchymal neoplasm of the soft... more...

Related Diseases for Chondrosarcoma, Extraskeletal Myxoid

Diseases related to Chondrosarcoma, Extraskeletal Myxoid via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 117)
# Related Disease Score Top Affiliating Genes
1 epithelial-myoepithelial carcinoma 32.7 NR4A3 SMARCB1 TAF15
2 myxoid chondrosarcoma 31.9 EWSR1 NR4A3 TAF15
3 extraosseous chondrosarcoma 31.4 ENO2 EWSR1 FUS SMARCB1 SNRPC SYP
4 chondrosarcoma 31.4 ENO2 EWSR1 NR4A3 TAF15 TFG
5 sarcoma 28.8 CREB3L2 DDIT3 EWSR1 FUS NR4A3 SS18
6 small cell osteogenic sarcoma 10.4 ENO2 EWSR1
7 cellular myxoid liposarcoma 10.4 EWSR1 FUS
8 askin's tumor 10.4 ENO2 EWSR1
9 carotid body cancer 10.4 ENO2 SYP
10 malignant sertoli cell tumor 10.4 ENO2 SYP
11 urinary bladder small cell neuroendocrine carcinoma 10.4 ENO2 SYP
12 auditory system cancer 10.4 ENO2 SYP
13 pediatric fibrosarcoma 10.4 EWSR1 TFG
14 sinonasal undifferentiated carcinoma 10.4 ENO2 SYP
15 pancreatic somatostatinoma 10.4 ENO2 SYP
16 cutaneous ganglioneuroma 10.4 ENO2 SYP
17 extrahepatic bile duct adenocarcinoma 10.4 ENO2 SYP
18 large cell carcinoma with rhabdoid phenotype 10.4 ENO2 SMARCB1
19 small cell carcinoma of the bladder 10.4 ENO2 SYP
20 papillary tumor of the pineal region 10.4 ENO2 SYP
21 sensory organ benign neoplasm 10.4 ENO2 SYP
22 melanotic medulloblastoma 10.4 ENO2 SMARCB1
23 orbital cancer 10.4 ENO2 SYP
24 middle ear adenoma 10.4 ENO2 SYP
25 vulvar sarcoma 10.4 EWSR1 SMARCB1
26 pulmonary large cell neuroendocrine carcinoma 10.4 ENO2 SYP
27 epithelioid malignant peripheral nerve sheath tumor 10.4 ENO2 SMARCB1
28 gallbladder small cell carcinoma 10.4 ENO2 SYP
29 atypical follicular adenoma 10.4 ENO2 SYP
30 central nervous system primitive neuroectodermal neoplasm 10.4 ENO2 SYP
31 cerebellum cancer 10.4 ENO2 SYP
32 clear cell ependymoma 10.4 ENO2 SYP
33 juxtacortical chondroma 10.4 EWSR1 FUS
34 cerebral neuroblastoma 10.4 ENO2 SYP
35 endometrial small cell carcinoma 10.4 ENO2 SYP
36 subependymal glioma 10.4 ENO2 SYP
37 malignant teratoma 10.4 ENO2 SYP
38 chordoma 10.4
39 atypical lipomatous tumor 10.4 FUS SMARCB1
40 astroblastoma 10.4 ENO2 SYP
41 olfactory nerve neoplasm 10.4 ENO2 SYP
42 pineal gland cancer 10.4 ENO2 SYP
43 autonomic nervous system benign neoplasm 10.3 ENO2 SYP
44 melanotic neuroectodermal tumor 10.3 ENO2 SYP
45 benign ependymoma 10.3 ENO2 SYP
46 nodular ganglioneuroblastoma 10.3 ENO2 SYP
47 severe acute respiratory syndrome 10.3
48 pineocytoma 10.3 ENO2 SYP
49 angiomyoma 10.3 ENO2 SYP
50 clear cell sarcoma 10.3 ENO2 EWSR1 FUS

Graphical network of the top 20 diseases related to Chondrosarcoma, Extraskeletal Myxoid:



Diseases related to Chondrosarcoma, Extraskeletal Myxoid

Symptoms & Phenotypes for Chondrosarcoma, Extraskeletal Myxoid

Human phenotypes related to Chondrosarcoma, Extraskeletal Myxoid:

33
# Description HPO Frequency HPO Source Accession
1 chondrosarcoma 33 HP:0006765

Clinical features from OMIM:

612237

Drugs & Therapeutics for Chondrosarcoma, Extraskeletal Myxoid

Drugs for Chondrosarcoma, Extraskeletal Myxoid (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 44)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ifosfamide Approved Phase 3,Phase 2 3778-73-2 3690
2
Mechlorethamine Approved, Investigational Phase 3,Phase 2 51-75-2 4033
3
Doxorubicin Approved, Investigational Phase 3,Phase 2,Phase 1 23214-92-8 31703
4
Cyclophosphamide Approved, Investigational Phase 2, Phase 3 6055-19-2, 50-18-0 2907
5
Trabectedin Approved, Investigational Phase 2, Phase 3 114899-77-3 108150
6
Doxil Approved June 1999 Phase 3,Phase 2,Phase 1 31703
7 Antineoplastic Agents, Alkylating Phase 3,Phase 2
8 Alkylating Agents Phase 3,Phase 2
9
Isophosphamide mustard Phase 3,Phase 2 0
10 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1
11 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1
12 Antibiotics, Antitubercular Phase 3,Phase 2,Phase 1
13
Temozolomide Approved, Investigational Phase 2 85622-93-1 5394
14
Allopurinol Approved Phase 2 315-30-0 2094
15
Loperamide Approved Phase 2 53179-11-6 3955
16
Mecasermin Approved, Investigational Phase 2 68562-41-4
17
Romidepsin Approved, Investigational Phase 2 128517-07-7 5352062
18
Sunitinib Approved, Investigational Phase 2 557795-19-4, 341031-54-7 5329102
19
Gemcitabine Approved Phase 2 95058-81-4 60750
20 Peripheral Nervous System Agents Phase 2
21 Antioxidants Phase 2
22 Antimetabolites Phase 2
23 Free Radical Scavengers Phase 2
24 Autonomic Agents Phase 2
25 Antidiarrheals Phase 2
26 Antirheumatic Agents Phase 2
27 Gastrointestinal Agents Phase 2
28 Protective Agents Phase 2
29 Antiemetics Phase 2
30 insulin Phase 2
31 Insulin, Globin Zinc Phase 2
32 Antibodies Phase 2,Phase 1
33 Mitogens Phase 2
34 Antibodies, Monoclonal Phase 2,Phase 1
35 Immunoglobulins Phase 2,Phase 1
36 Angiogenesis Modulating Agents Phase 2
37 Protein Kinase Inhibitors Phase 2
38 Angiogenesis Inhibitors Phase 2
39 Immunosuppressive Agents Phase 2
40 lysine Phase 2,Phase 1
41 Antimetabolites, Antineoplastic Phase 2
42 Immunologic Factors Phase 2
43 Anti-Infective Agents Phase 2
44 Antiviral Agents Phase 2

Interventional clinical trials:

(show all 19)
# Name Status NCT ID Phase Drugs
1 Observation, Radiation Therapy, Combination Chemotherapy, and/or Surgery in Treating Young Patients With Soft Tissue Sarcoma Completed NCT00346164 Phase 3 doxorubicin hydrochloride;ifosfamide
2 Randomised Trial of Volume of Post-operative Radiotherapy Given to Adult Patients With eXtremity Soft Tissue Sarcoma Completed NCT00423618 Phase 3
3 Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery Active, not recruiting NCT02180867 Phase 2, Phase 3 Doxorubicin Hydrochloride;Ifosfamide;Pazopanib Hydrochloride
4 Doxorubicin Hydrochloride or Trabectedin in Treating Patients With Previously Untreated Advanced or Metastatic Soft Tissue Sarcoma Terminated NCT01189253 Phase 2, Phase 3 doxorubicin hydrochloride;trabectedin
5 Trial of Pazopanib in Patients With Solitary Fibrous Tumor and Extraskeletal Myxoid Chondrosarcoma Unknown status NCT02066285 Phase 2 Pazopanib
6 Temozolomide in Treating Patients With Advanced Soft Tissue Sarcoma Unknown status NCT00003718 Phase 2 temozolomide
7 A Trial of Perifosine in Patients With Chemo-Insensitive Sarcomas Completed NCT00401388 Phase 2 Perifosine
8 A Study of R1507 in Participants With Recurrent or Refractory Sarcoma Completed NCT00642941 Phase 2 RG1507
9 Depsipeptide (Romidepsin) in Treating Patients With Metastatic or Unresectable Soft Tissue Sarcoma Completed NCT00112463 Phase 2 romidepsin
10 Vismodegib and Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Advanced or Metastatic Sarcoma Completed NCT01154452 Phase 1, Phase 2 Gamma-Secretase Inhibitor RO4929097;Vismodegib
11 Image-Guided Radiation Therapy in Treating Patients With Primary Soft Tissue Sarcoma of the Shoulder, Arm, Hip, or Leg Completed NCT00589121 Phase 2 Chemotherapy
12 Sunitinib in Treating Patients With Metastatic, Locally Advanced, or Locally Recurrent Sarcomas Completed NCT00474994 Phase 2 sunitinib malate
13 Proton or Photon RT for Retroperitoneal Sarcomas Recruiting NCT01659203 Phase 1, Phase 2
14 A Phase II, Multicenter Study of the EZH2 Inhibitor Tazemetostat in Adult Subjects With INI1-Negative Tumors or Relapsed/Refractory Synovial Sarcoma Recruiting NCT02601950 Phase 2 Tazemetostat
15 Gemcitabine Hydrochloride With or Without Pazopanib Hydrochloride in Treating Patients With Refractory Soft Tissue Sarcoma Recruiting NCT01532687 Phase 2 Gemcitabine Hydrochloride;Pazopanib Hydrochloride
16 Intensity-Modulated Radiation Therapy in Treating Patients Undergoing Surgery for Stage IB, Stage II, or Stage III Soft Tissue Sarcoma Terminated NCT00740597 Phase 2
17 Cixutumumab and Doxorubicin Hydrochloride in Treating Patients With Unresectable, Locally Advanced, or Metastatic Soft Tissue Sarcoma Completed NCT00720174 Phase 1 Doxorubicin Hydrochloride
18 A Phase 1 Study of the EZH2 Inhibitor Tazemetostat in Pediatric Subjects With Relapsed or Refractory INI1-Negative Tumors or Synovial Sarcoma Recruiting NCT02601937 Phase 1 Tazemetostat
19 Tissue Sample Collection From Patients With Soft Tissue Sarcoma of the Arms, Hands, Legs, or Feet Treated on Clinial Trial CRUK-VORTEX Unknown status NCT00900211

Search NIH Clinical Center for Chondrosarcoma, Extraskeletal Myxoid

Cochrane evidence based reviews: chondrosarcoma, extraskeletal myxoid

Genetic Tests for Chondrosarcoma, Extraskeletal Myxoid

Anatomical Context for Chondrosarcoma, Extraskeletal Myxoid

MalaCards organs/tissues related to Chondrosarcoma, Extraskeletal Myxoid:

42
Lung, Bone, Heart, Breast, Cerebellum, Liver, Bone Marrow

Publications for Chondrosarcoma, Extraskeletal Myxoid

Articles related to Chondrosarcoma, Extraskeletal Myxoid:

(show top 50) (show all 188)
# Title Authors Year
1
Systemic manifestations of extraskeletal myxoid chondrosarcoma associated with a novel t(2;22)(q34;q12) EWS translocation in a child and a review of the literature. ( 30776935 )
2019
2
Molecular and Clinicopathologic Heterogeneity of Intracranial Tumors Mimicking Extraskeletal Myxoid Chondrosarcoma. ( 29924341 )
2018
3
Extraskeletal Myxoid Chondrosarcoma: A Comparative Study of Imaging and Pathology. ( 29977924 )
2018
4
Identification of an Actionable Mutation of KIT in a Case of Extraskeletal Myxoid Chondrosarcoma. ( 29937513 )
2018
5
INSM1 expression and its diagnostic significance in extraskeletal myxoid chondrosarcoma. ( 29327709 )
2018
6
Extraskeletal Myxoid Chondrosarcoma of Nasopharynx: An Oncologic Entity Rarely Reported. ( 29657686 )
2018
7
Intraluminal EWSR1-CREB1 gene rearranged, low-grade myxoid sarcoma of the pulmonary artery resembling extraskeletal myxoid chondrosarcoma (EMC). ( 30326150 )
2018
8
Fine-needle aspiration features of extraskeletal myxoid chondrosarcoma: A study of cytological and molecular features. ( 30353688 )
2018
9
Extraskeletal myxoid chondrosarcoma with massive pulmonary metastases. ( 30534357 )
2018
10
Primary pulmonary myxoid sarcoma, a potential mimic of metastatic extraskeletal myxoid chondrosarcoma. ( 29110880 )
2017
11
Curious case of extraskeletal myxoid chondrosarcoma. ( 28360467 )
2017
12
Next generation sequencing of extraskeletal myxoid chondrosarcoma. ( 28423517 )
2017
13
Extraskeletal myxoid chondrosarcoma of the masticator space in a pediatric patient. ( 28638563 )
2017
14
Primary extraskeletal myxoid chondrosarcoma in cerebellum: A case report with literature review: Erratum. ( 29390404 )
2017
15
HSPA8 as a novel fusion partner of NR4A3 in extraskeletal myxoid chondrosarcoma. ( 28383167 )
2017
16
Primary extraskeletal myxoid chondrosarcoma of bone: Report of three cases and review of the literature. ( 28249774 )
2017
17
Primary extraskeletal myxoid chondrosarcoma in cerebellum: A case report with literature review. ( 29381948 )
2017
18
A rare manifestation of extraskeletal myxoid chondrosarcoma with a huge expanding hematoma. ( 28187993 )
2017
19
Results of sub-analysis of a phase 2 study on trabectedin treatment for extraskeletal myxoid chondrosarcoma and mesenchymal chondrosarcoma. ( 27418251 )
2016
20
Pulmonary extraskeletal myxoid chondrosarcoma: A case report and literature review. ( 27591381 )
2016
21
Extraskeletal Myxoid Chondrosarcoma of the Orbit. ( 27162461 )
2016
22
Extraskeletal Myxoid Chondrosarcoma of the Foot Clinically Mimicking Plantar Fibromatosis. ( 27655120 )
2016
23
Benefit of Radiotherapy in Extraskeletal Myxoid Chondrosarcoma: A Propensity Score Weighted Population-based Analysis of the SEER Database. ( 27819877 )
2016
24
Clinicopathologic and radiologic features of extraskeletal myxoid chondrosarcoma: a retrospective study of 40 Chinese cases with literature review. ( 27402218 )
2016
25
Diagnosis of extraskeletal myxoid chondrosarcoma in the thigh using EWSR1-NR4A3 gene fusion: a case report. ( 27832806 )
2016
26
Extraskeletal myxoid chondrosarcoma of maxilla: A rare entity. ( 27194880 )
2016
27
Extraskeletal myxoid chondrosarcoma of the vulva: A case report. ( 26622802 )
2015
28
Breast Metastasis of Extraskeletal Myxoid Chondrosarcoma: A Case Report. ( 26125202 )
2015
29
Spontaneous Regression of Metastatic Extraskeletal Myxoid Chondrosarcoma. ( 26434451 )
2015
30
Extraskeletal Myxoid Chondrosarcoma Presenting as a Plantar Fibroma: Case Report and Review of the Literature. ( 26504046 )
2015
31
Paravertebral extraskeletal myxoid chondrosarcoma: a case report and review of the literature. ( 26448808 )
2015
32
Unresectable Extraskeletal Myxoid Chondrosarcoma of the Neck: Early Tumor Response to Chemoradiotherapy. ( 26848421 )
2015
33
Primary extraskeletal myxoid chondrosarcoma of pulmonary arteries: a rare mimic of acute pulmonary thromboembolism. ( 25564577 )
2015
34
Extraskeletal myxoid chondrosarcoma presenting as an intradural spinal mass: report of a rare clinical presentation with an emphasis on differential diagnostic considerations. ( 25568751 )
2014
35
Extraskeletal myxoid chondrosarcoma of the thigh in a child: a case report. ( 25550031 )
2014
36
Activity of sunitinib in extraskeletal myxoid chondrosarcoma. ( 24703573 )
2014
37
Extraskeletal myxoid chondrosarcoma with a t(9;16)(q22;p11.2) resulting in a NR4A3-FUS fusion. ( 25130955 )
2014
38
Clinical and radiologic features of extraskeletal myxoid chondrosarcoma including initial presentation, local recurrence, and metastases. ( 25177237 )
2014
39
Extraskeletal myxoid chondrosarcoma with non-EWSR1-NR4A3 variant fusions correlate with rhabdoid phenotype and high-grade morphology. ( 24746215 )
2014
40
Extraskeletal myxoid chondrosarcoma: A report of two cases. ( 24944710 )
2014
41
Diagnostic utility of molecular investigation in extraskeletal myxoid chondrosarcoma. ( 24508382 )
2014
42
Extraskeletal myxoid chondrosarcoma arising in the femoral vein: a case report. ( 24818862 )
2014
43
Extraskeletal Myxoid Chondrosarcoma of the Vulva With PLAG1 Gene Activation: Molecular Genetic Characterization of 2 Cases. ( 24185117 )
2013
44
Extraskeletal myxoid chondrosarcoma of the neck. ( 23230139 )
2013
45
Osseous myxochondroid sarcoma: a detailed study of 5 cases of extraskeletal myxoid chondrosarcoma of the bone. ( 23588370 )
2013
46
Anthracycline-based chemotherapy in extraskeletal myxoid chondrosarcoma: a retrospective study. ( 24345066 )
2013
47
Multicentric extraskeletal myxoid chondrosarcoma of uterine adnexa in a young female: an unusual presentation. ( 22499307 )
2012
48
Primary pulmonary myxoid sarcoma with EWSR1-CREB1 fusion, resembling extraskeletal myxoid chondrosarcoma: Case report with a review of Literature. ( 23252871 )
2012
49
Extraskeletal myxoid chondrosarcoma: a review of 23 patients treated at a single referral center with long-term follow-up. ( 22678528 )
2012
50
Identification of genes regulated by the EWS/NR4A3 fusion protein in extraskeletal myxoid chondrosarcoma. ( 22592656 )
2012

Variations for Chondrosarcoma, Extraskeletal Myxoid

Cosmic variations for Chondrosarcoma, Extraskeletal Myxoid:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM6944849 SMAD2 bone,extraskeletal,chondrosarcoma,myxoid c.3G>A p.M1I 18:47896754-47896754 0
2 COSM5324 PTEN bone,extraskeletal,chondrosarcoma,myxoid c.522T>G p.Y174* 10:87952147-87952147 0
3 COSM6912431 PRKN bone,extraskeletal,chondrosarcoma,myxoid c.678G>T p.L226F 6:161973358-161973358 0
4 COSM6917156 PIK3C3 bone,extraskeletal,chondrosarcoma,myxoid c.1109A>T p.H370L 18:42004480-42004480 0
5 COSM221068 KMT2D bone,extraskeletal,chondrosarcoma,myxoid c.7088C>A p.S2363* 12:49039872-49039872 0
6 COSM251400 ARID1A bone,extraskeletal,chondrosarcoma,myxoid c.3424C>T p.Q1142* 1:26772517-26772517 0
7 COSM6912432 bone,extraskeletal,chondrosarcoma,myxoid c.678G>T p.L226F 6:161973358-161973358 0
8 COSM221069 bone,extraskeletal,chondrosarcoma,myxoid c.7898C>A p.S2633* 12:49039872-49039872 0
9 COSM6944850 bone,extraskeletal,chondrosarcoma,myxoid c.3G>A p.M1I 18:47896754-47896754 0

Expression for Chondrosarcoma, Extraskeletal Myxoid

Search GEO for disease gene expression data for Chondrosarcoma, Extraskeletal Myxoid.

Pathways for Chondrosarcoma, Extraskeletal Myxoid

Pathways related to Chondrosarcoma, Extraskeletal Myxoid according to KEGG:

38
# Name Kegg Source Accession
1 Transcriptional misregulation in cancer hsa05202

Pathways related to Chondrosarcoma, Extraskeletal Myxoid according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.76 EWSR1 FUS SMARCB1 SS18 TAF15
2 11.37 DDIT3 EWSR1 FUS NR4A3 SS18 TAF15

GO Terms for Chondrosarcoma, Extraskeletal Myxoid

Cellular components related to Chondrosarcoma, Extraskeletal Myxoid according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleoplasm GO:0005654 9.65 CREB3L2 DDIT3 FUS NPM3 NR4A2 NR4A3
2 nucleus GO:0005634 9.47 CREB3L2 DDIT3 EWSR1 FUS NPM3 NR4A2
3 SWI/SNF complex GO:0016514 9.26 SMARCB1 SS18
4 npBAF complex GO:0071564 9.16 SMARCB1 SS18

Biological processes related to Chondrosarcoma, Extraskeletal Myxoid according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.8 CREB3L2 DDIT3 NR4A2 NR4A3 SMARCB1 SS18
2 regulation of transcription, DNA-templated GO:0006355 9.76 CREB3L2 DDIT3 EWSR1 FUS NR4A2 NR4A3
3 positive regulation of transcription, DNA-templated GO:0045893 9.23 CREB3L2 DDIT3 NR4A2 NR4A3 SS18 TAF15
4 cellular response to corticotropin-releasing hormone stimulus GO:0071376 8.96 NR4A2 NR4A3

Molecular functions related to Chondrosarcoma, Extraskeletal Myxoid according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA binding GO:0003677 9.85 CREB3L2 DDIT3 FUS NR4A2 NR4A3 SMARCB1
2 DNA-binding transcription factor activity GO:0003700 9.73 CREB3L2 DDIT3 NR4A2 NR4A3 TCF12 ZNF444
3 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.43 CREB3L2 DDIT3 NR4A2 NR4A3 SMARCB1 TCF12
4 retinoid X receptor binding GO:0046965 9.37 FUS NR4A2
5 glucocorticoid receptor binding GO:0035259 9.32 NR4A2 NR4A3
6 cAMP response element binding GO:0035497 8.8 CREB3L2 NR4A3 TCF12

Sources for Chondrosarcoma, Extraskeletal Myxoid

3 CDC
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17 EFO
18 ExPASy
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35 ICD10 via Orphanet
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37 IUPHAR
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