EMC
MCID: CHN056
MIFTS: 45

Chondrosarcoma, Extraskeletal Myxoid (EMC)

Categories: Cancer diseases, Genetic diseases, Rare diseases

Aliases & Classifications for Chondrosarcoma, Extraskeletal Myxoid

MalaCards integrated aliases for Chondrosarcoma, Extraskeletal Myxoid:

Name: Chondrosarcoma, Extraskeletal Myxoid 57 13 44
Extraskeletal Myxoid Chondrosarcoma 12 59 37 15 73
Myxoid Extraosseous Chondrosarcoma 12
Emc 57

Characteristics:

Orphanet epidemiological data:

59
extraskeletal myxoid chondrosarcoma
Inheritance: Not applicable; Age of onset: Adult; Age of death: adult;

HPO:

32
chondrosarcoma, extraskeletal myxoid:
Inheritance somatic mutation


Classifications:



External Ids:

OMIM 57 612237
Disease Ontology 12 DOID:6496
MeSH 44 C563195
NCIt 50 C27502
Orphanet 59 ORPHA209916
UMLS via Orphanet 74 C1275278
ICD10 via Orphanet 34 C49.9
MedGen 42 C1275278
KEGG 37 H00053
SNOMED-CT via HPO 69 124975008 14990007 443520009
UMLS 73 C1275278

Summaries for Chondrosarcoma, Extraskeletal Myxoid

OMIM : 57 Extraskeletal myxoid chondrosarcoma is a rare soft tissue neoplasm of chondroblastic origin. The tumors are most commonly found in middle-aged and elderly individuals, are more common among men, and are often detected as deep-seated lesions in the extremities. Despite their relatively low-grade malignancy, recurrence and metastasis may appear many years after the initial diagnosis. Histologic tissue section examination reveals a mixture of cellular and myxoid stromal components (Panagopoulos et al., 2002). (612237)

MalaCards based summary : Chondrosarcoma, Extraskeletal Myxoid, also known as extraskeletal myxoid chondrosarcoma, is related to epithelial-myoepithelial carcinoma and extraosseous chondrosarcoma. An important gene associated with Chondrosarcoma, Extraskeletal Myxoid is NR4A3 (Nuclear Receptor Subfamily 4 Group A Member 3), and among its related pathways/superpathways are Transcriptional misregulation in cancer and Chromatin Regulation / Acetylation. The drugs Abraxane and Emend have been mentioned in the context of this disorder. Affiliated tissues include bone, heart and cerebellum, and related phenotypes are chondrosarcoma and shRNA abundance <= 50%

Disease Ontology : 12 An extraosseous chondrosarcoma that has material basis in cells derived from transformed cells that produce cartilage and is characterized by a marked abundance of extracellular mucoid (myxoid) matrix.

Related Diseases for Chondrosarcoma, Extraskeletal Myxoid

Diseases related to Chondrosarcoma, Extraskeletal Myxoid via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 124)
# Related Disease Score Top Affiliating Genes
1 epithelial-myoepithelial carcinoma 32.5 NR4A3 SMARCB1 TAF15
2 extraosseous chondrosarcoma 32.2 ENO2 EWSR1 FUS SMARCB1 SNRPC SYP
3 myxoid chondrosarcoma 31.7 EWSR1 NR4A3 TAF15
4 chondrosarcoma 31.4 ENO2 EWSR1 NR4A3 TAF15 TFG
5 sarcoma 29.0 CREB3L2 DDIT3 EWSR1 FUS NR4A3 SS18
6 chordoma 10.4
7 severe acute respiratory syndrome 10.3
8 small cell osteogenic sarcoma 10.3 ENO2 EWSR1
9 cellular myxoid liposarcoma 10.3 EWSR1 FUS
10 askin's tumor 10.3 ENO2 EWSR1
11 carotid body cancer 10.3 ENO2 SYP
12 malignant sertoli cell tumor 10.3 ENO2 SYP
13 urinary bladder small cell neuroendocrine carcinoma 10.3 ENO2 SYP
14 auditory system cancer 10.3 ENO2 SYP
15 pediatric fibrosarcoma 10.3 EWSR1 TFG
16 sinonasal undifferentiated carcinoma 10.3 ENO2 SYP
17 gallbladder small cell carcinoma 10.3 ENO2 SYP
18 pancreatic somatostatinoma 10.3 ENO2 SYP
19 large cell carcinoma with rhabdoid phenotype 10.3 ENO2 SMARCB1
20 cutaneous ganglioneuroma 10.3 ENO2 SYP
21 extrahepatic bile duct adenocarcinoma 10.3 ENO2 SYP
22 small cell carcinoma of the bladder 10.3 ENO2 SYP
23 melanotic medulloblastoma 10.3 ENO2 SMARCB1
24 papillary tumor of the pineal region 10.3 ENO2 SYP
25 sensory organ benign neoplasm 10.3 ENO2 SYP
26 orbital cancer 10.3 ENO2 SYP
27 middle ear adenoma 10.3 ENO2 SYP
28 vulvar sarcoma 10.3 EWSR1 SMARCB1
29 pulmonary large cell neuroendocrine carcinoma 10.3 ENO2 SYP
30 sarcomatosis 10.3 EWSR1 WT1
31 epithelioid malignant peripheral nerve sheath tumor 10.3 ENO2 SMARCB1
32 atypical follicular adenoma 10.3 ENO2 SYP
33 central nervous system primitive neuroectodermal neoplasm 10.3 ENO2 SYP
34 cerebellum cancer 10.3 ENO2 SYP
35 clear cell ependymoma 10.3 ENO2 SYP
36 cerebral neuroblastoma 10.2 ENO2 SYP
37 endometrial small cell carcinoma 10.2 ENO2 SYP
38 juxtacortical chondroma 10.2 EWSR1 FUS
39 subependymal glioma 10.2 ENO2 SYP
40 malignant teratoma 10.2 ENO2 SYP
41 peritoneal serous adenocarcinoma 10.2 SYP WT1
42 atypical lipomatous tumor 10.2 FUS SMARCB1
43 astroblastoma 10.2 ENO2 SYP
44 olfactory nerve neoplasm 10.2 ENO2 SYP
45 pineal gland cancer 10.2 ENO2 SYP
46 autonomic nervous system benign neoplasm 10.2 ENO2 SYP
47 myxofibrosarcoma 10.2 CREB3L2 FUS
48 melanotic neuroectodermal tumor 10.2 ENO2 SYP
49 sclerosing liposarcoma 10.2 CREB3L2 FUS
50 benign ependymoma 10.2 ENO2 SYP

Graphical network of the top 20 diseases related to Chondrosarcoma, Extraskeletal Myxoid:



Diseases related to Chondrosarcoma, Extraskeletal Myxoid

Symptoms & Phenotypes for Chondrosarcoma, Extraskeletal Myxoid

Clinical features from OMIM:

612237

Human phenotypes related to Chondrosarcoma, Extraskeletal Myxoid:

32
# Description HPO Frequency HPO Source Accession
1 chondrosarcoma 32 HP:0006765

GenomeRNAi Phenotypes related to Chondrosarcoma, Extraskeletal Myxoid according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 shRNA abundance <= 50% GR00343-S 9.32 CREB3L2 DDIT3 FUS NR4A2 NR4A3 SMARCB1

Drugs & Therapeutics for Chondrosarcoma, Extraskeletal Myxoid

FDA approved drugs:

# Drug Name Active Ingredient(s) 18 Company Approval Date
1
Abraxane 18 49 PACLITAXEL Celgene October 2012
2
Emend 18 49 APREPITANT FOSAPREPITANT DIMEGLUMINE Merck March 2003
3
Gemzar 18 49 GEMCITABINE HYDROCHLORIDE Eli Lilly May 1996
4
Tarceva 18 49 ERLOTINIB HYDROCHLORIDE Genentech, OSI Pharmaceuticals November, 2004
5
Portazza 18 NECITUMUMAB Eli Lilly November 2015

Drugs for Chondrosarcoma, Extraskeletal Myxoid (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 44)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyclophosphamide Approved, Investigational Phase 2, Phase 3 6055-19-2, 50-18-0 2907
2
Mechlorethamine Approved, Investigational Phase 2, Phase 3,Phase 3 51-75-2 4033
3
Doxorubicin Approved, Investigational Phase 2, Phase 3,Phase 3,Phase 1 23214-92-8 31703
4
Ifosfamide Approved Phase 2, Phase 3,Phase 3 3778-73-2 3690
5
Trabectedin Approved, Investigational Phase 2, Phase 3 114899-77-3 108150
6
Doxil Approved June 1999 Phase 2, Phase 3,Phase 3,Phase 1 31703
7 Antineoplastic Agents, Alkylating Phase 2, Phase 3,Phase 3
8 Alkylating Agents Phase 2, Phase 3,Phase 3
9
Isophosphamide mustard Phase 2, Phase 3,Phase 3 0
10 Anti-Bacterial Agents Phase 2, Phase 3,Phase 3,Phase 1
11 Antibiotics, Antitubercular Phase 2, Phase 3,Phase 3,Phase 1
12 Topoisomerase Inhibitors Phase 2, Phase 3,Phase 3,Phase 1
13
Dacarbazine Approved, Investigational Phase 2 4342-03-4 5351166
14
Temozolomide Approved, Investigational Phase 2 85622-93-1 5394
15
Allopurinol Approved Phase 2 315-30-0 2094
16
Loperamide Approved Phase 2 53179-11-6 3955
17
Mecasermin Approved, Investigational Phase 2 68562-41-4
18
Romidepsin Approved, Investigational Phase 2 128517-07-7 5352062
19
Gemcitabine Approved Phase 2 95058-81-4 60750
20
Sunitinib Approved, Investigational Phase 2 557795-19-4, 341031-54-7 5329102
21 Antidiarrheals Phase 2
22 Free Radical Scavengers Phase 2
23 Antimetabolites Phase 2
24 Antioxidants Phase 2
25 Antiemetics Phase 2
26 Gastrointestinal Agents Phase 2
27 Antirheumatic Agents Phase 2
28 Autonomic Agents Phase 2
29 Protective Agents Phase 2
30 Peripheral Nervous System Agents Phase 2
31 Mitogens Phase 2
32 Insulin, Globin Zinc Phase 2
33 Antibodies, Monoclonal Phase 2,Phase 1
34 Immunoglobulins Phase 2,Phase 1
35 insulin Phase 2
36 Antibodies Phase 2,Phase 1
37 lysine Phase 2,Phase 1
38 Antiviral Agents Phase 2
39 Immunosuppressive Agents Phase 2
40 Antimetabolites, Antineoplastic Phase 2
41 Anti-Infective Agents Phase 2
42 Immunologic Factors Phase 2
43 Angiogenesis Modulating Agents Phase 2
44 Angiogenesis Inhibitors Phase 2

Interventional clinical trials:

(show all 19)
# Name Status NCT ID Phase Drugs
1 Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery Suspended NCT02180867 Phase 2, Phase 3 Doxorubicin Hydrochloride;Ifosfamide;Pazopanib Hydrochloride
2 Observation, Radiation Therapy, Combination Chemotherapy, and/or Surgery in Treating Young Patients With Soft Tissue Sarcoma Completed NCT00346164 Phase 3 doxorubicin hydrochloride;ifosfamide
3 Doxorubicin Hydrochloride or Trabectedin in Treating Patients With Previously Untreated Advanced or Metastatic Soft Tissue Sarcoma Terminated NCT01189253 Phase 2, Phase 3 doxorubicin hydrochloride;trabectedin
4 Randomised Trial of Volume of Post-operative Radiotherapy Given to Adult Patients With eXtremity Soft Tissue Sarcoma Active, not recruiting NCT00423618 Phase 3
5 Trial of Pazopanib in Patients With Solitary Fibrous Tumor and Extraskeletal Myxoid Chondrosarcoma Unknown status NCT02066285 Phase 2 Pazopanib
6 Temozolomide in Treating Patients With Advanced Soft Tissue Sarcoma Unknown status NCT00003718 Phase 2 temozolomide
7 A Trial of Perifosine in Patients With Chemo-Insensitive Sarcomas Completed NCT00401388 Phase 2 Perifosine
8 Proton or Photon RT for Retroperitoneal Sarcomas Recruiting NCT01659203 Phase 1, Phase 2
9 A Study of R1507 in Participants With Recurrent or Refractory Sarcoma Completed NCT00642941 Phase 2 RG1507
10 A Phase II, Multicenter Study of the EZH2 Inhibitor Tazemetostat in Adult Subjects With INI1-Negative Tumors or Relapsed/Refractory Synovial Sarcoma Recruiting NCT02601950 Phase 2 Tazemetostat
11 Depsipeptide (Romidepsin) in Treating Patients With Metastatic or Unresectable Soft Tissue Sarcoma Completed NCT00112463 Phase 2 romidepsin
12 Gemcitabine Hydrochloride With or Without Pazopanib Hydrochloride in Treating Patients With Refractory Soft Tissue Sarcoma Recruiting NCT01532687 Phase 2 Gemcitabine Hydrochloride;Pazopanib Hydrochloride
13 Vismodegib and Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Advanced or Metastatic Sarcoma Completed NCT01154452 Phase 1, Phase 2 Gamma-Secretase Inhibitor RO4929097;Vismodegib
14 Intensity-Modulated Radiation Therapy in Treating Patients Undergoing Surgery for Stage IB, Stage II, or Stage III Soft Tissue Sarcoma Terminated NCT00740597 Phase 2
15 Image-Guided Radiation Therapy in Treating Patients With Primary Soft Tissue Sarcoma of the Shoulder, Arm, Hip, or Leg Completed NCT00589121 Phase 2 Chemotherapy
16 Sunitinib in Treating Patients With Metastatic, Locally Advanced, or Locally Recurrent Sarcomas Completed NCT00474994 Phase 2 sunitinib malate
17 A Phase 1 Study of the EZH2 Inhibitor Tazemetostat in Pediatric Subjects With Relapsed or Refractory INI1-Negative Tumors or Synovial Sarcoma Active, not recruiting NCT02601937 Phase 1 Tazemetostat
18 Cixutumumab and Doxorubicin Hydrochloride in Treating Patients With Unresectable, Locally Advanced, or Metastatic Soft Tissue Sarcoma Completed NCT00720174 Phase 1 Doxorubicin Hydrochloride
19 Tissue Sample Collection From Patients With Soft Tissue Sarcoma of the Arms, Hands, Legs, or Feet Treated on Clinial Trial CRUK-VORTEX Unknown status NCT00900211

Search NIH Clinical Center for Chondrosarcoma, Extraskeletal Myxoid

Cochrane evidence based reviews: chondrosarcoma, extraskeletal myxoid

Genetic Tests for Chondrosarcoma, Extraskeletal Myxoid

Anatomical Context for Chondrosarcoma, Extraskeletal Myxoid

MalaCards organs/tissues related to Chondrosarcoma, Extraskeletal Myxoid:

41
Bone, Heart, Cerebellum, Skin, Brain, Kidney, Pineal

Publications for Chondrosarcoma, Extraskeletal Myxoid

Articles related to Chondrosarcoma, Extraskeletal Myxoid:

(show top 50) (show all 187)
# Title Authors Year
1
Molecular and Clinicopathologic Heterogeneity of Intracranial Tumors Mimicking Extraskeletal Myxoid Chondrosarcoma. ( 29924341 )
2018
2
Extraskeletal Myxoid Chondrosarcoma: A Comparative Study of Imaging and Pathology. ( 29977924 )
2018
3
Identification of an Actionable Mutation of KIT in a Case of Extraskeletal Myxoid Chondrosarcoma. ( 29937513 )
2018
4
Extraskeletal Myxoid Chondrosarcoma of Nasopharynx: An Oncologic Entity Rarely Reported. ( 29657686 )
2018
5
Intraluminal EWSR1-CREB1 gene rearranged, low-grade myxoid sarcoma of the pulmonary artery resembling extraskeletal myxoid chondrosarcoma (EMC). ( 30326150 )
2018
6
Fine-needle aspiration features of extraskeletal myxoid chondrosarcoma: A study of cytological and molecular features. ( 30353688 )
2018
7
Extraskeletal myxoid chondrosarcoma with massive pulmonary metastases. ( 30534357 )
2018
8
INSM1 expression and its diagnostic significance in extraskeletal myxoid chondrosarcoma. ( 29327709 )
2018
9
Primary pulmonary myxoid sarcoma, a potential mimic of metastatic extraskeletal myxoid chondrosarcoma. ( 29110880 )
2017
10
Curious case of extraskeletal myxoid chondrosarcoma. ( 28360467 )
2017
11
Next generation sequencing of extraskeletal myxoid chondrosarcoma. ( 28423517 )
2017
12
Extraskeletal myxoid chondrosarcoma of the masticator space in a pediatric patient. ( 28638563 )
2017
13
Primary extraskeletal myxoid chondrosarcoma in cerebellum: A case report with literature review: Erratum. ( 29390404 )
2017
14
HSPA8 as a novel fusion partner of NR4A3 in extraskeletal myxoid chondrosarcoma. ( 28383167 )
2017
15
Primary extraskeletal myxoid chondrosarcoma of bone: Report of three cases and review of the literature. ( 28249774 )
2017
16
Primary extraskeletal myxoid chondrosarcoma in cerebellum: A case report with literature review. ( 29381948 )
2017
17
A rare manifestation of extraskeletal myxoid chondrosarcoma with a huge expanding hematoma. ( 28187993 )
2017
18
Results of sub-analysis of a phase 2 study on trabectedin treatment for extraskeletal myxoid chondrosarcoma and mesenchymal chondrosarcoma. ( 27418251 )
2016
19
Pulmonary extraskeletal myxoid chondrosarcoma: A case report and literature review. ( 27591381 )
2016
20
Extraskeletal Myxoid Chondrosarcoma of the Orbit. ( 27162461 )
2016
21
Extraskeletal Myxoid Chondrosarcoma of the Foot Clinically Mimicking Plantar Fibromatosis. ( 27655120 )
2016
22
Benefit of Radiotherapy in Extraskeletal Myxoid Chondrosarcoma: A Propensity Score Weighted Population-based Analysis of the SEER Database. ( 27819877 )
2016
23
Clinicopathologic and radiologic features of extraskeletal myxoid chondrosarcoma: a retrospective study of 40 Chinese cases with literature review. ( 27402218 )
2016
24
Diagnosis of extraskeletal myxoid chondrosarcoma in the thigh using EWSR1-NR4A3 gene fusion: a case report. ( 27832806 )
2016
25
Extraskeletal myxoid chondrosarcoma of maxilla: A rare entity. ( 27194880 )
2016
26
Extraskeletal myxoid chondrosarcoma of the vulva: A case report. ( 26622802 )
2015
27
Breast Metastasis of Extraskeletal Myxoid Chondrosarcoma: A Case Report. ( 26125202 )
2015
28
Spontaneous Regression of Metastatic Extraskeletal Myxoid Chondrosarcoma. ( 26434451 )
2015
29
Extraskeletal Myxoid Chondrosarcoma Presenting as a Plantar Fibroma: Case Report and Review of the Literature. ( 26504046 )
2015
30
Paravertebral extraskeletal myxoid chondrosarcoma: a case report and review of the literature. ( 26448808 )
2015
31
Unresectable Extraskeletal Myxoid Chondrosarcoma of the Neck: Early Tumor Response to Chemoradiotherapy. ( 26848421 )
2015
32
Primary extraskeletal myxoid chondrosarcoma of pulmonary arteries: a rare mimic of acute pulmonary thromboembolism. ( 25564577 )
2015
33
Extraskeletal myxoid chondrosarcoma presenting as an intradural spinal mass: report of a rare clinical presentation with an emphasis on differential diagnostic considerations. ( 25568751 )
2014
34
Extraskeletal myxoid chondrosarcoma of the thigh in a child: a case report. ( 25550031 )
2014
35
Activity of sunitinib in extraskeletal myxoid chondrosarcoma. ( 24703573 )
2014
36
Extraskeletal myxoid chondrosarcoma with a t(9;16)(q22;p11.2) resulting in a NR4A3-FUS fusion. ( 25130955 )
2014
37
Clinical and radiologic features of extraskeletal myxoid chondrosarcoma including initial presentation, local recurrence, and metastases. ( 25177237 )
2014
38
Extraskeletal myxoid chondrosarcoma with non-EWSR1-NR4A3 variant fusions correlate with rhabdoid phenotype and high-grade morphology. ( 24746215 )
2014
39
Extraskeletal myxoid chondrosarcoma: A report of two cases. ( 24944710 )
2014
40
Diagnostic utility of molecular investigation in extraskeletal myxoid chondrosarcoma. ( 24508382 )
2014
41
Extraskeletal myxoid chondrosarcoma arising in the femoral vein: a case report. ( 24818862 )
2014
42
Extraskeletal Myxoid Chondrosarcoma of the Vulva With PLAG1 Gene Activation: Molecular Genetic Characterization of 2 Cases. ( 24185117 )
2013
43
Extraskeletal myxoid chondrosarcoma of the neck. ( 23230139 )
2013
44
Osseous myxochondroid sarcoma: a detailed study of 5 cases of extraskeletal myxoid chondrosarcoma of the bone. ( 23588370 )
2013
45
Anthracycline-based chemotherapy in extraskeletal myxoid chondrosarcoma: a retrospective study. ( 24345066 )
2013
46
Multicentric extraskeletal myxoid chondrosarcoma of uterine adnexa in a young female: an unusual presentation. ( 22499307 )
2012
47
Primary pulmonary myxoid sarcoma with EWSR1-CREB1 fusion, resembling extraskeletal myxoid chondrosarcoma: Case report with a review of Literature. ( 23252871 )
2012
48
Extraskeletal myxoid chondrosarcoma: a review of 23 patients treated at a single referral center with long-term follow-up. ( 22678528 )
2012
49
Identification of genes regulated by the EWS/NR4A3 fusion protein in extraskeletal myxoid chondrosarcoma. ( 22592656 )
2012
50
Intra-articular extraskeletal myxoid chondrosarcoma of the ankle. ( 22438126 )
2012

Variations for Chondrosarcoma, Extraskeletal Myxoid

Cosmic variations for Chondrosarcoma, Extraskeletal Myxoid:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM6944849 SMAD2 bone,extraskeletal,chondrosarcoma,myxoid c.3G>A p.M1I 18:47896754-47896754 16
2 COSM5324 PTEN bone,extraskeletal,chondrosarcoma,myxoid c.522T>G p.Y174* 10:87952147-87952147 16
3 COSM6912431 PRKN bone,extraskeletal,chondrosarcoma,myxoid c.678G>T p.L226F 6:161973358-161973358 16
4 COSM6917156 PIK3C3 bone,extraskeletal,chondrosarcoma,myxoid c.1109A>T p.H370L 18:42004480-42004480 16
5 COSM221068 KMT2D bone,extraskeletal,chondrosarcoma,myxoid c.7088C>A p.S2363* 12:49039872-49039872 16
6 COSM251400 ARID1A bone,extraskeletal,chondrosarcoma,myxoid c.3424C>T p.Q1142* 1:26772517-26772517 16
7 COSM6912432 bone,extraskeletal,chondrosarcoma,myxoid c.678G>T p.L226F 6:161973358-161973358 16
8 COSM221069 bone,extraskeletal,chondrosarcoma,myxoid c.7898C>A p.S2633* 12:49039872-49039872 16
9 COSM6944850 bone,extraskeletal,chondrosarcoma,myxoid c.3G>A p.M1I 18:47896754-47896754 16

Expression for Chondrosarcoma, Extraskeletal Myxoid

Search GEO for disease gene expression data for Chondrosarcoma, Extraskeletal Myxoid.

Pathways for Chondrosarcoma, Extraskeletal Myxoid

Pathways related to Chondrosarcoma, Extraskeletal Myxoid according to KEGG:

37
# Name Kegg Source Accession
1 Transcriptional misregulation in cancer hsa05202

Pathways related to Chondrosarcoma, Extraskeletal Myxoid according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.76 EWSR1 FUS SMARCB1 SS18 TAF15
2 11.44 DDIT3 EWSR1 FUS NR4A3 SS18 TAF15

GO Terms for Chondrosarcoma, Extraskeletal Myxoid

Cellular components related to Chondrosarcoma, Extraskeletal Myxoid according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleoplasm GO:0005654 9.7 CREB3L2 DDIT3 FUS NPM3 NR4A2 NR4A3
2 nucleus GO:0005634 9.53 CREB3L2 DDIT3 EWSR1 FUS MRTFB NPM3
3 SWI/SNF complex GO:0016514 9.26 SMARCB1 SS18
4 npBAF complex GO:0071564 9.16 SMARCB1 SS18

Biological processes related to Chondrosarcoma, Extraskeletal Myxoid according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of transcription, DNA-templated GO:0006355 9.81 CREB3L2 DDIT3 EWSR1 FUS NR4A2 NR4A3
2 transcription by RNA polymerase II GO:0006366 9.72 CREB3L2 NR4A2 TAF15 TCF12 WT1
3 positive regulation of transcription by RNA polymerase II GO:0045944 9.61 CREB3L2 DDIT3 MRTFB NR4A2 NR4A3 SMARCB1
4 positive regulation of transcription, DNA-templated GO:0045893 9.28 CREB3L2 DDIT3 NR4A2 NR4A3 SS18 TAF15
5 cellular response to corticotropin-releasing hormone stimulus GO:0071376 9.26 NR4A2 NR4A3

Molecular functions related to Chondrosarcoma, Extraskeletal Myxoid according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription factor activity GO:0003700 9.87 CREB3L2 DDIT3 NR4A2 NR4A3 TCF12 WT1
2 transcription coactivator activity GO:0003713 9.73 FUS MRTFB SMARCB1 SS18
3 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.73 CREB3L2 DDIT3 NR4A2 NR4A3 SMARCB1 TCF12
4 DNA binding GO:0003677 9.7 CREB3L2 DDIT3 FUS NR4A2 NR4A3 SMARCB1
5 transcription regulatory region DNA binding GO:0044212 9.67 CREB3L2 DDIT3 TCF12 WT1
6 retinoid X receptor binding GO:0046965 9.48 FUS NR4A2
7 glucocorticoid receptor binding GO:0035259 9.46 NR4A2 NR4A3
8 cAMP response element binding GO:0035497 9.33 CREB3L2 NR4A3 TCF12
9 proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001077 9.1 CREB3L2 DDIT3 NR4A2 NR4A3 TCF12 WT1
10 protein binding GO:0005515 10.31 DDIT3 ENO2 EWSR1 FUS MRTFB NPM3
11 metal ion binding GO:0046872 10.21 ENO2 EWSR1 FUS NR4A2 NR4A3 SNRPC
12 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 10.04 CREB3L2 DDIT3 NR4A2 NR4A3 TCF12 WT1

Sources for Chondrosarcoma, Extraskeletal Myxoid

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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