MCID: CHR033
MIFTS: 33

Chordoid Glioma

Categories: Cancer diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Chordoid Glioma

MalaCards integrated aliases for Chordoid Glioma:

Name: Chordoid Glioma 12 60 15
Chordoid Glioma of the Third Ventricle 74

Characteristics:

Orphanet epidemiological data:

60
chordoid glioma
Age of onset: Adult; Age of death: adult;

Classifications:

Orphanet: 60  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:3774
NCIt 51 C5592
ICD10 via Orphanet 35 C71.9
Orphanet 60 ORPHA251674
UMLS 74 C1322252

Summaries for Chordoid Glioma

MalaCards based summary : Chordoid Glioma, also known as chordoid glioma of the third ventricle, is related to third ventricle chordoid glioma and glioma. An important gene associated with Chordoid Glioma is GFAP (Glial Fibrillary Acidic Protein), and among its related pathways/superpathways are Neuroscience and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Dabrafenib and Vincristine have been mentioned in the context of this disorder. Affiliated tissues include brain, thyroid and testes, and related phenotype is Decreased cell migration.

Related Diseases for Chordoid Glioma

Diseases related to Chordoid Glioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 177)
# Related Disease Score Top Affiliating Genes
1 third ventricle chordoid glioma 12.6
2 glioma 11.0
3 localized hypertrophic neuropathy 10.3 MUC1 S100B
4 sclerosing perineurioma 10.3 MUC1 S100B
5 perineurioma 10.3 MUC1 S100B
6 reticular perineurioma 10.3 MUC1 S100B
7 neuronal ceroid-lipofuscinoses 10.3 GFAP S100B
8 gliosarcoma 10.3 GFAP S100B
9 non-functioning pituitary adenoma 10.3 MUC1 S100B
10 functioning pituitary adenoma 10.3 MUC1 S100B
11 epithelioid malignant peripheral nerve sheath tumor 10.3 MUC1 S100B
12 ossifying fibromyxoid tumor 10.3 MUC1 S100B
13 eccrine porocarcinoma 10.3 MUC1 S100B
14 aggressive digital papillary adenocarcinoma 10.3 MUC1 S100B
15 monophasic synovial sarcoma 10.3 MUC1 S100B
16 spiradenoma 10.3 MUC1 S100B
17 gemistocytic astrocytoma 10.3 GFAP S100B
18 pleomorphic liposarcoma 10.3 MUC1 S100B
19 cutaneous leiomyosarcoma 10.3 GFAP MUC1
20 parachordoma 10.2 GFAP MUC1
21 oncocytoma 10.2 MUC1 SYP
22 meningeal melanocytoma 10.2 MUC1 S100B
23 cystadenoma 10.2 MUC1 SYP
24 clear cell meningioma 10.2 GFAP MUC1
25 dendritic cell tumor 10.2 MUC1 S100B
26 primary hepatic neuroendocrine carcinoma 10.2 S100B SYP
27 mixed type thymoma 10.2 S100B SYP
28 hypoganglionosis 10.2 S100B SYP
29 rosette-forming glioneuronal tumor 10.2 S100B SYP
30 sinonasal undifferentiated carcinoma 10.2 MUC1 SYP
31 supratentorial cancer 10.2 GFAP SYP
32 atypical teratoid rhabdoid tumor 10.2 GFAP SYP
33 granular cell tumor 10.2 GFAP S100B
34 cerebrum cancer 10.2 GFAP SYP
35 supratentorial primitive neuroectodermal tumor 10.2 S100B SYP
36 polymorphous low-grade adenocarcinoma 10.2 MUC1 S100B
37 papillary tumor of the pineal region 10.2 MUC1 SYP
38 middle ear adenoma 10.2 MUC1 SYP
39 hemangiopericytoma, malignant 10.2 MUC1 S100B
40 ovarian small cell carcinoma 10.2 MUC1 SYP
41 traumatic brain injury 10.2 GFAP S100B
42 desmoplastic infantile ganglioglioma 10.2 GFAP SYP
43 extraventricular neurocytoma 10.2 GFAP SYP
44 brain injury 10.2 GFAP S100B
45 intraneural perineurioma 10.2 MUC1 S100B
46 lung combined type small cell carcinoma 10.2 GFAP SYP
47 cellular ependymoma 10.2 GFAP SYP
48 papillary carcinoma 10.2 MUC1 NKX2-1
49 adenosquamous carcinoma 10.2 MUC1 NKX2-1
50 malignant pleural mesothelioma 10.2 MUC1 NKX2-1

Graphical network of the top 20 diseases related to Chordoid Glioma:



Diseases related to Chordoid Glioma

Symptoms & Phenotypes for Chordoid Glioma

GenomeRNAi Phenotypes related to Chordoid Glioma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased cell migration GR00055-A-1 8.8 MUC1 NF2 PRKCA

Drugs & Therapeutics for Chordoid Glioma

Drugs for Chordoid Glioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dabrafenib Approved, Investigational Phase 2 1195765-45-7 44462760 44516822
2
Vincristine Approved, Investigational Phase 2 2068-78-2, 57-22-7 5978
3
Carboplatin Approved Phase 2 41575-94-4 38904 10339178 498142
4
Trametinib Approved Phase 2 871700-17-3 11707110
5 Protein Kinase Inhibitors Phase 2
6 Antimitotic Agents Phase 2
7 Antineoplastic Agents, Phytogenic Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase II Pediatric Study With Dabrafenib in Combination With Trametinib in Patients With HGG and LGG Recruiting NCT02684058 Phase 2 dabrafenib;trametinib;Carboplatin with vincristine

Search NIH Clinical Center for Chordoid Glioma

Genetic Tests for Chordoid Glioma

Anatomical Context for Chordoid Glioma

MalaCards organs/tissues related to Chordoid Glioma:

42
Brain, Thyroid, Testes, Hypothalamus

Publications for Chordoid Glioma

Articles related to Chordoid Glioma:

(show top 50) (show all 74)
# Title Authors Year
1
Chordoid Glioma Infiltrating Optic Structures. ( 30829943 )
2019
2
A recurrent kinase domain mutation in PRKCA defines chordoid glioma of the third ventricle. ( 29476136 )
2018
3
The trans-laminar terminalis approach reduces mortalities associated with chordoid glioma resections: A case report and a review of 20a8^years of literature. ( 29066234 )
2018
4
Gross Total Resection of Chordoid Glioma of the Third Ventricle via Anterior Interhemispheric Transcallosal Transforaminal Approach at Two Stages. ( 29588902 )
2018
5
Letter to the editor regarding "The trans-laminar terminalis approach reduces mortalities associated with chordoid glioma resections: A case report and a review of 20a8^years of literature". ( 29605280 )
2018
6
Chordoid Glioma with Psychosis: Case Report. ( 30188563 )
2018
7
Usefulness of neuroimaging and immunohistochemical study for accurate diagnosis of chordoid glioma of the third ventricle: A case report and review of the literature. ( 30533273 )
2018
8
Suprasellar chordoid glioma: a report of two cases. ( 30624507 )
2018
9
Chordoid Glioma: A Neoplasm Found in the Anterior Part of the Third Ventricle. ( 28708638 )
2017
10
Management in chordoid glioma: Avoiding the pitfalls in this rare and challenging entity. ( 28681757 )
2017
11
Chordoid glioma of the third ventricle: report of a rapidly progressive case. ( 28315998 )
2017
12
Corrigendum to "The radiological findings of chordoid glioma: report of two cases, one case with MR spectroscopy" [Clin Imaging 39 (2015) 1086-1089]. ( 27133706 )
2016
13
Chordoid Glioma of Third Ventricle With an Epidermoid Cyst: Coexistence or Common Histogenesis? ( 27194402 )
2016
14
Neurogenic fever in a patient with a chordoid glioma. ( 27856533 )
2016
15
Chordoid glioma of the third ventricle: a patient presenting with SIADH and a review of this rare tumor. ( 26879322 )
2016
16
Expanded Endoscopic Transnasal Approach to the Chordoid Glioma of the Third Ventricle : The First Case Ever Reported. ( 27847580 )
2016
17
Chordoid Glioma with Intraventricular Dissemination: A Case Report with Perfusion MR Imaging Features. ( 26798226 )
2016
18
Chordoid glioma: A new paradigm of hypothalamic dysfunction? ( 27798757 )
2016
19
Chordoid glioma: a rare radiologically, histologically, and clinically mystifying lesion. ( 26018908 )
2015
20
Suprasellar chordoid neoplasm with expression of thyroid transcription factor 1: evidence that chordoid glioma of the third ventricle and pituicytoma may form part of a spectrum of lineage-related tumors of the basal forebrain. ( 25934249 )
2015
21
Chordoid glioma. ( 26668411 )
2015
22
Chordoid glioma: Case report and review of the literature. ( 25648470 )
2015
23
Chordoid glioma of the third ventricle. ( 26543291 )
2015
24
The radiological findings of chordoid glioma: report of two cases, one case with MR spectroscopy. ( 26275847 )
2015
25
Expression of thyroid transcription factor 1 in a chordoid glioma. ( 25248954 )
2014
26
Neuro-Ophthalmologic Features of Chordoid Glioma. ( 24113763 )
2013
27
Therapeutic approach to chordoid glioma of the third ventricle. ( 23615418 )
2013
28
Chordoid glioma of the third ventricle: four cases including one case with papillary features. ( 22716306 )
2013
29
Chordoid glioma: a rare suprasellar mass. ( 22644806 )
2012
30
Chordoid glioma of the third ventricle. ( 22754136 )
2012
31
Cytology of chordoid glioma of the third ventricle. ( 22246938 )
2012
32
CD99 is expressed in chordoid glioma and suggests ependymal origin. ( 22102064 )
2012
33
Chordoid glioma in suprasellar location with extension into the third ventricle: smear preparation morphology of a rare tumor. ( 22246933 )
2012
34
Rarest of the rare: Chordoid glioma infiltrating the optic chiasm. ( 21697970 )
2011
35
Chordoid glioma: a case report and literature review. ( 21192197 )
2011
36
Chordoid glioma of the third ventricle: a case report with review of literature. ( 21743188 )
2011
37
Chordoid glioma: imaging pearls of a unique third ventricular tumor. ( 21059517 )
2010
38
Chordoid glioma: ten years of a low-grade tumor with high morbidity. ( 20808539 )
2010
39
Chordoid glioma : a case report of unusual location and neuroradiological characteristics. ( 20717514 )
2010
40
Chordoid glioma with calcification and neurofilament expression: case report and review of the literature. ( 18262609 )
2009
41
Chordoid glioma with calcification and neurofilament expression: case report and review of the literature (Iwami et al. Surg Neurol 2008;10.1016/j.surneu.2007.07.032). ( 19329155 )
2009
42
Diabetes insipidus, panhypopituitarism, and severe mental status deterioration in a patient with chordoid glioma: case report and literature review. ( 19364693 )
2009
43
Chordoid glioma of the third ventricle: a report of two cases, one with ultrastructural findings. ( 18498285 )
2009
44
Chordoid glioma: a case report and molecular characterization of five cases. ( 18652591 )
2009
45
Chordoid glioma of the third ventricle attached to the optic chiasm. Successful removal through a trans-lamina terminalis approach. ( 18597929 )
2008
46
Chordoid glioma of the third ventricle. ( 18936876 )
2008
47
Chordoid glioma: report of two rare examples with unusual features. ( 18246456 )
2008
48
An incidentally detected third ventricle chordoid glioma. ( 18040120 )
2007
49
Extraventricular unusual glioma in a child with extensive myxoid change resembling chordoid glioma. ( 17965223 )
2007
50
Test and teach. A recurrent third ventricular brain tumour. Diagnosis: Chordoid glioma of the third ventricle. ( 16753749 )
2006

Variations for Chordoid Glioma

Expression for Chordoid Glioma

Search GEO for disease gene expression data for Chordoid Glioma.

Pathways for Chordoid Glioma

Pathways related to Chordoid Glioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.56 GFAP NF2 NKX2-1 S100B SYP
2 11.03 GFAP S100B SYP

GO Terms for Chordoid Glioma

Biological processes related to Chordoid Glioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hippocampus development GO:0021766 9.16 NF2 NKX2-1
2 long-term synaptic potentiation GO:0060291 8.96 GFAP S100B
3 regulation of neuronal synaptic plasticity GO:0048168 8.62 S100B SYP

Sources for Chordoid Glioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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