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MCID: CHR005
MIFTS: 51

Chorioamnionitis

Categories: Fetal diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Chorioamnionitis

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MalaCards integrated aliases for Chorioamnionitis:

Name: Chorioamnionitis 12 54 43 15 17 71

Classifications:

MalaCards categories:
Global: Fetal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:0050697
MeSH 43 D002821
UMLS 71 C0008495
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Summaries for Chorioamnionitis

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Disease Ontology : 12 A placenta disease that is an inflammation of the fetal membranes (amnion and chorion) due to a bacterial infection.

MalaCards based summary : Chorioamnionitis is related to listeriosis and funisitis. An important gene associated with Chorioamnionitis is IL6 (Interleukin 6), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Cefuroxime and Cefazolin have been mentioned in the context of this disorder. Affiliated tissues include placenta, lung and brain, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 74 Chorioamnionitis also known as intra-amniotic infection (IAI) is an inflammation of the fetal membranes... more...

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Related Diseases for Chorioamnionitis

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Diseases related to Chorioamnionitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 784)
# Related Disease Score Top Affiliating Genes
1 listeriosis 32.7 TNF TLR4 IL6 IL1B IL10
2 funisitis 32.4 TNF S100A12 MMP8 IL6 IL1B IL10
3 bronchopulmonary dysplasia 31.5 IL1RN FLT1 ELANE CXCL8
4 periventricular leukomalacia 31.3 TNF IL6 IL1R1 IL18
5 endometritis 31.2 TNF TLR4 OXT IL6 IL1B CXCL8
6 vasculitis 30.9 TNF IL6 IL10 ELANE CRP CCL2
7 pain agnosia 30.8 OXT IL6 IL1B
8 asphyxia neonatorum 30.8 OXT IL6 CRP
9 perinatal necrotizing enterocolitis 30.8 TNF TLR4 IL6 IL1B IL10 CXCL8
10 cerebral palsy 30.7 TNF TLR4 MMP8 IL6 IL1B IL18
11 haemophilus influenzae 30.7 TNF CXCL8
12 meconium aspiration syndrome 30.7 TNF OXT IL6 CXCL8
13 eclampsia 30.7 VEGFA TNF OXT IL6 FLT1
14 preterm premature rupture of the membranes 30.6 TNF TLR4 OXT MMP9 MMP8 IL6
15 vaginal discharge 30.5 TNF OXT IL6 IL1B CXCL8 CRP
16 cervicitis 30.5 TNF TLR4 IL6 IL1B CXCL8
17 trichomoniasis 30.5 TNF IL6 IL1B CXCL8
18 thrombocytosis 30.4 IL6 IL1B IL1A CRP
19 candidiasis 30.4 TNF TLR4 IL6 IL1B IL10 CXCL8
20 graft-versus-host disease 30.4 TNF IL6 IL1B IL1A IL10
21 placental insufficiency 30.4 VEGFA IL6 FLT1 CXCL8
22 disseminated intravascular coagulation 30.3 TNF IL6 IL10 ELANE CRP
23 newborn respiratory distress syndrome 30.2 IL6 IL1B ELANE CXCL8 CRP
24 food allergy 30.2 TNF TLR4 IL10 CXCL8
25 tetanus 30.2 TNF IL6 IL1B IL1A IL10 CRP
26 bacterial vaginosis 30.2 TNF TLR4 MMP8 IL6 IL1RN IL1B
27 conjunctivitis 30.2 TNF MMP9 IL6 IL10 CXCL8 CCL2
28 adenomyosis 30.1 VEGFA OXT MMP9 IL6 CXCL8
29 rubella 30.1 TNF TLR4 IL6 IL1B IL10
30 severe pre-eclampsia 30.1 VEGFA TLR4 MMP9
31 toxoplasmosis 30.1 TNF TLR4 IL6 IL1B IL10
32 bacteriuria 30.1 TLR4 IL6 IL18 CXCL8 CRP CCL2
33 necrotizing fasciitis 30.1 IL6 IL1RN IL1B IL18 CXCL8 CRP
34 intestinal perforation 30.1 VEGFA TNF TLR4 IL6 CRP
35 fasciitis 30.1 TNF IL6 IL1RN IL18 CXCL8 CRP
36 endometriosis 30.0 VEGFA IL6 IL1B CXCL8 CCL2
37 vaginitis 30.0 TNF TLR4 IL6 IL1B IL1A IL10
38 pulmonary emphysema 30.0 VEGFA MMP9 MMP8 ELANE CXCL8
39 pulmonary edema 30.0 TNF OXT IL1B IL10 CXCL8 CRP
40 immune deficiency disease 29.9 TNF IL6 IL1A IL18 IL10 CCL2
41 septic arthritis 29.9 TREM1 TNF TLR4 IL6 IL1B CXCL8
42 acute cystitis 29.8 TNF TLR4 IL6 IL1B IL18 IL10
43 pertussis 29.8 TNF TLR4 IL6 IL1B IL1A IL10
44 chlamydia 29.7 TNF TLR4 IL6 IL1B IL1A IL18
45 placenta disease 29.7 VEGFA TNF TLR4 OXT IL6 IL1B
46 dermatitis 29.7 TNF IL6 IL1B IL1A IL18 IL10
47 adult respiratory distress syndrome 29.7 TNF IL6 IL1R1 IL1B IL10 ELANE
48 stroke, ischemic 29.6 VEGFA TNF TLR4 MMP9 IL6 IL1B
49 appendicitis 29.6 TNF TLR4 MMP9 MMP8 IL6 IL1B
50 pyelonephritis 29.6 TNF TLR4 IL6 IL1B IL1A IL10

Graphical network of the top 20 diseases related to Chorioamnionitis:



Diseases related to Chorioamnionitis
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Symptoms & Phenotypes for Chorioamnionitis

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MGI Mouse Phenotypes related to Chorioamnionitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.3 CRP FLT1 IL10 IL18 IL1A IL1B
2 homeostasis/metabolism MP:0005376 10.3 CRP ELANE FLT1 IL10 IL18 IL1A
3 hematopoietic system MP:0005397 10.25 ELANE FLT1 IL10 IL18 IL1A IL1B
4 immune system MP:0005387 10.25 CCL2 CRP ELANE FLT1 IL10 IL18
5 digestive/alimentary MP:0005381 10.09 IL10 IL18 IL1R1 IL6 MMP9 OXT
6 integument MP:0010771 10.07 ELANE IL10 IL18 IL1A IL1B IL1R1
7 muscle MP:0005369 9.81 FLT1 IL10 IL18 IL1R1 IL6 MMP9
8 neoplasm MP:0002006 9.73 ELANE IL10 IL1A IL1B IL1R1 IL6
9 vision/eye MP:0005391 9.28 FLT1 IL10 IL18 IL1R1 IL6 MMP9
Sources

Drugs & Therapeutics for Chorioamnionitis

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Drugs for Chorioamnionitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 152)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cefuroxime Approved Phase 4 55268-75-2 5479529 5361202
2
Cefazolin Approved Phase 4 25953-19-9 656510 33255
3
Azithromycin Approved Phase 4 83905-01-5 447043 55185
4
Misoprostol Approved Phase 4 59122-46-2 5282381
5
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
6
Progesterone Approved, Vet_approved Phase 4 57-83-0 5994
7
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
8
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
9 cefuroxime axetil Phase 4
10 Gastrointestinal Agents Phase 4
11 Antacids Phase 4
12 Anti-Ulcer Agents Phase 4
13 Progestins Phase 4
14 Lactoferrin Phase 4
15 Gentamicins Phase 4
16 Respiratory System Agents Phase 4
17 Clindamycin phosphate Phase 4
18 Clindamycin palmitate Phase 4
19 Hormones Phase 4
20 Anti-Asthmatic Agents Phase 4
21 Hormone Antagonists Phase 4
22 glucocorticoids Phase 4
23 Anti-Inflammatory Agents Phase 4
24
Sulbactam Approved Phase 2, Phase 3 68373-14-8
25
Sultamicillin Approved, Investigational Phase 2, Phase 3 76497-13-7
26
Nevirapine Approved Phase 3 129618-40-2 4463
27
Metronidazole Approved Phase 3 443-48-1 4173
28
Clarithromycin Approved Phase 3 81103-11-9 84029
29
Dinoprostone Approved Phase 3 363-24-6 5280360
30
Hydrocortisone Approved, Vet_approved Phase 3 50-23-7 5754
31
Hydrocortisone acetate Approved, Vet_approved Phase 3 50-03-3
32
Carbetocin Approved, Investigational Phase 3 37025-55-1 71715 16681432
33
Ampicillin Approved, Vet_approved Phase 3 69-53-4 6249
34
Erythromycin Approved, Investigational, Vet_approved Phase 3 114-07-8 12560 441411
35
Nitric Oxide Approved Phase 3 10102-43-9 145068
36
Isosorbide Dinitrate Approved, Investigational Phase 3 87-33-2 6883
37
AT-101 Approved, Investigational Phase 3 652-67-5, 90141-22-3 12597
38
Chlorhexidine Approved, Vet_approved Phase 3 55-56-1 9552079 2713
39
Iodine Approved, Investigational Phase 3 7553-56-2 807
40
Povidone Approved Phase 3 9003-39-8
41
Povidone-iodine Approved Phase 3 25655-41-8
42
Nifedipine Approved Phase 3 21829-25-4 4485
43
Folic acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
44
Pyridoxine Approved, Investigational, Nutraceutical, Vet_approved Phase 3 65-23-6 1054
45 Antiviral Agents Phase 3
46 Antiprotozoal Agents Phase 3
47 Anti-HIV Agents Phase 3
48 Reverse Transcriptase Inhibitors Phase 3
49 Antiparasitic Agents Phase 3
50 Anti-Retroviral Agents Phase 3

Interventional clinical trials:

(show top 50) (show all 154)
# Name Status NCT ID Phase Drugs
1 Comparison of Two Antibiotic Prophylactic Protocols in Preterm Premature Rupture of the Membranes. A Randomized Prospective, Open Trial Unknown status NCT02819570 Phase 4 I.V cefuroxime 750 mg*3/d for 2 days;I.V ampicillin 2 gram x4/d for 2 days;P.O cefuroxime 500 mgx2/d for 5 days;P.O roxithromycin 150 mg*2/d for 7 days;P.O moxypen 500 mgx3/d for 5 days
2 The Effect of Maternal Antenatal Steroid Administration on the Blood Flow Through the Pulmonary Artery in the Term Fetus; a Randomized Control Double Blinded Study Unknown status NCT02978976 Phase 4 Betamethasone;saline
3 Foley Bulb With Oral Misoprostol Versus Oral Misoprostol for Induction of Labor: A Cluster Randomized Trial Completed NCT03407625 Phase 4
4 Increased Cefazolin (Ancef) Dosing for Prophylaxis During Cesarean Delivery in the Obese Population Completed NCT02049944 Phase 4 Cefazolin
5 Comparison of Subcuticular Suture Type in Post-Cesarean Wound Complications Completed NCT02459093 Phase 4
6 POM PROM: Pitocin or Oral Misoprostol for PROM IOL in Nulliparous Women With Unfavorable Cervical Exams Recruiting NCT04028765 Phase 4 Misoprostol;Oxytocin
7 The Effect of Antibiotics on Latency in Previable Prelabor Rupture of Membranes Between 18 0/7 and 22 6/7 Weeks Gestational Age Recruiting NCT04047849 Phase 4 Antibiotics, oral Azithromycin and oral Amoxicillin
8 Lactoferrin or Progesterone for Prevention of Preterm Delivery Active, not recruiting NCT02372942 Phase 4 Lattoferrin;Progesterone
9 Treatment Utility of Postpartum Antibiotics in Chorioamnionitis Terminated NCT01585129 Phase 4 Postpartum Antibiotics;No postpartum antibiotics
10 Removal Versus Retention of Cervical Cerclage in Preterm Premature Rupture of Membranes-A Multicenter Randomized Clinical Trial Terminated NCT00201656 Phase 4
11 Randomized Trial on Efficacy and Safety of the Antenatal Rescue Course of Glucocorticoids in Threatened Premature Birth (ACG Trial) Terminated NCT00295464 Phase 4 Betamethasone sodium phos (drug)
12 A Randomized Trial in Intrapartum Fever Of No Antibiotics for Low-risk Women (RATIONAL) Withdrawn NCT03168178 Phase 4 Standard Antibiotic Treatment
13 A Study Aimed at Comparing Two Methods of Contractions Monitoring (Electrical Uterine Monitor - EUM vs. Tocodynamometer) for Clinical Decision Making Regarding Treatment Among Pregnant Women With Preterm Contractions. Unknown status NCT02875418 Phase 3
14 Antibiotic Prophylaxis in Prelabor Rupture of Membranes at Term - a Randomized Controlled Trial Completed NCT01633294 Phase 2, Phase 3 Ampicillin + gentamicin
15 Comparison of Ampicillin / Sulbactam vs. Ampicillin / Gentamicin for Treatment of Intrapartum Chorioamnionitis: a Randomized Controlled Trial Completed NCT00879190 Phase 2, Phase 3 Unasyn;Ampicillin/gentamicin
16 Phase III Trial of Antibiotics to Reduce Chorioamnionitis-Related Perinatal HIV Transmission Completed NCT00021671 Phase 3 Erythromycin;Nevirapine;Ampicillin sodium;Metronidazole
17 Randomized Phase III Trial of Cefazolin or Combination of Cefazolin and Erythromycin or Cefazolin and Clarithromycin in Women With Preterm Premature Rupture of the Membranes Completed NCT01401179 Phase 3 cefazolin, erythromycin, clarithromycin
18 The Efficacy of Symbiotic Preparation on Cytokines Which Act on Necrotising Enterocolitis Pathogenesis in Very Low Birth Weight Infants Completed NCT01899677 Phase 3 symbiotic
19 Combined Spinal and Epidural Anesthesia and Maternal Intrapartum Temperature During Vaginal Delivery: a Randomized Clinical Trial Completed NCT01078519 Phase 3 Combined epidural and spinal anesthesia
20 Induction of Labor in Term Premature Rupture of Membranes: A Comparison Between Oxytocin and Dinoprostone Followed Six Hours Later by Oxytocin Completed NCT01099280 Phase 3 SYNPITAN FORT 5 IU;Propess,SYNPITAN FORT
21 Early Prevention of Broncho-pulmonary Dysplasia and Neonatal Mortality in Very Preterm Infants Using Low Dose of Hydrocortisone: a Randomized Controlled Trial Completed NCT00623740 Phase 3 hydrocortisone;placebo
22 Comparison of the Efficacy of Oral Progesterone and Vaginal Progesterone After Tocolytic Therapy in Threatened Preterm Labor Completed NCT02989519 Phase 3 dydrogesterone;Micronized progesterone
23 Carbetocin in Preventing Postpartum Bleeding in Women With Severe Preeclampsia. Completed NCT02086994 Phase 3 misoprostol;carbetocin
24 Tocolysis in the Management of Preterm Premature Rupture of Membranes Before 34 Weeks of Gestation: a Double-blinded Randomized Controlled Trial Recruiting NCT03976063 Phase 3 Nifedipine;Placebo of Nifedipine
25 Nitric Oxide Donor Isosorbide Mono Nitrate for Cervical Ripening in Induction of Labor in Term or Post Term Pregnancies in Females With Pre-labor Rupture of Membranes Recruiting NCT03665779 Phase 3 isosorbide mononitrate;Placebo
26 TREAT: Treatment of ppROM With Erythromycin vs. Azithromycin Trial Recruiting NCT03060473 Phase 3 Azithromycin;Erythromycin;Ampicillin;Amoxicillin
27 Efficacy of Prophylactic IgM-Enriched Immunoglobulin for the Management of Early-Onset Neonatal Sepsis in Very Low Birth Weight Preterm Neonates; A Randomized Controlled Trial Not yet recruiting NCT04041765 Phase 3 IgM-enriched IVIG
28 A Randomized Trial to Investigate if a Pre-operative Wash With Chlorhexidine vs Povidone-iodine Vaginal Scrub Decreases Infectious Morbidity in Patients Undergoing Cesarean Section After Ruptured Membranes Not yet recruiting NCT03925155 Phase 3 EZ scrub vaginal chlorhexidine 4% solution;10% provodine-iodine vaginal preparation
29 Effect of Autologous Cord Blood Mononuclear Cells for Prevention of Bronchopulmonary Dysplasia in Extremely Preterm Neonates: a Placebo-controlled Randomized Multicenter Trial Not yet recruiting NCT04440670 Phase 3
30 Study of Different Doses of Nifedipine to Treat Preterm Labor Terminated NCT00137501 Phase 3 Nifedipine
31 Can Safety Planning Improve Perinatal Outcomes Among Pregnant Women Exposed to Intimate Partner Violence? Withdrawn NCT00831831 Phase 3
32 ADDATION OF Azithromycin TO CEFAZOLIN PRE ELECTIVE C S Unknown status NCT03502356 Phase 1, Phase 2 Azithromycin
33 Is More Than One Dose of Misoprostol Needed to Expedite Vaginal Delivery in a Patient With an Unripe Cervix? Unknown status NCT02680314 Phase 2 Misoprostol
34 Safety of N-acetylcysteine in Maternal Chorioamnionitis Completed NCT00724594 Phase 1, Phase 2 N-acetylcysteine;Control
35 Maternal Effects of Bacterial Vaginosis (BV) Treatment in Pregnancy (Randomized Trial of BV Treatment in Pregnancy) Completed NCT00153517 Phase 2 oral versus vaginal metronidazole
36 A Randomized Controlled Trial Comparing Normal Saline With and Without Dextrose on the Course of Labor in Nulliparas Completed NCT00569439 Phase 2 D5NS;D10NS;NS
37 Effect of N-acetylcysteine in Preventing Adverse Neonatal Outcomes in Women With Intra-amniotic Infection/Inflammation Completed NCT00397735 Phase 1, Phase 2 N-acetylcysteine or placebo
38 Trial II of Lung Protection With Azithromycin in the Preterm Infant Completed NCT00319956 Phase 2 Azithromycin;Placebo
39 Concurrent Versus Sequential Administration of Amniotomy and Oxytocin for Augmentation of Labour: a Randomized Controlled Trial Completed NCT02318121 Phase 2 Oxytocin
40 Effects of Melatonin as a Novel Antioxidant and Free Radicals Scavenger in Neonatal Sepsis Completed NCT03295162 Phase 1, Phase 2 Melatonin 10 mg
41 Randomized Controlled Trial of Mupirocin to Reduce Staphylococcus Aureus Colonization in Infants Hospitalized in a Neonatal Intensive Care Unit Recruiting NCT02967432 Phase 2 Mupirocin Topical Ointment;Petroleum Jelly
42 Randomized Control Trial of Intravenous Acetaminophen (OFIRMEV) for the Reduction of Intrapartum Maternal Fever and Fetal Tachycardia Active, not recruiting NCT02625454 Phase 2 Intravenous Acetaminophen;Oral Acetaminophen
43 Intracervical Catheters for Induction of Labour in Women With Prelabour Rupture of Membranes at Term: A Pilot Study. Terminated NCT00890630 Phase 2 Oxytocin
44 Phase 2 Study of Oral Probiotics Reduce the Incidence and Severity of Necrotizing Enterocolitis for Very Low Birth Weight Infants -Multi-Center Randomized Control Trial Terminated NCT00540033 Phase 2
45 A Randomized Trial of Foley Bulb Induction With and Without Simultaneous Use of Oxytocin Completed NCT02098421 Phase 1 Oxytocin
46 Clinical Trial: Security and Feasibility of Mesenchymal Stem Cell Therapy in Treatment and Prevention of Bronchopulmonary Dysplasia in Preterm Babies Recruiting NCT02443961 Phase 1
47 Changes in Blood Flow in MCA of Fetuses to Mothers Having Clinical Chorioamnionitis During Labor Comparing to Fetuses to Healthy Mothers. Unknown status NCT00299637
48 S100B as a Marker for Fetal Brain Injury in Premature Rupture of Membranes Unknown status NCT01778725
49 Closure of Skin in ChorioAmnionitis Research Pilot Study Unknown status NCT01988168
50 Contribution of the Study of Maternal Plasmatic Regulator T Cells and Th17 for the Diagnosis of Acute Chorioanmionitis Among Women Hospitalized for Premature Rupture of Fetal Membranes (PPROM) Between 24 and 34 Gestation Weeks Unknown status NCT01610258

Search NIH Clinical Center for Chorioamnionitis

Cochrane evidence based reviews: chorioamnionitis

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Genetic Tests for Chorioamnionitis

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Anatomical Context for Chorioamnionitis

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MalaCards organs/tissues related to Chorioamnionitis:

40
Placenta, Lung, Brain, Colon, Testes, Neutrophil, Uterus
Sources

Publications for Chorioamnionitis

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Articles related to Chorioamnionitis:

(show top 50) (show all 3909)
# Title Authors PMID Year
1
Labor induction with a Foley balloon inflated to 30 mL compared with 60 mL: a randomized controlled trial. 54 61
20502296 2010
2
IL-6 and TNFalpha across the umbilical circulation in term pregnancies: relationship with labour events. 54 61
20171025 2010
3
Accuracy of C-reactive protein determination in predicting chorioamnionitis and neonatal infection in pregnant women with premature rupture of membranes: a systematic review. 61 54
19819609 2009
4
Intravenous oxytocin alone for cervical ripening and induction of labour. 61 54
19821304 2009
5
The association between intrauterine inflammation and spontaneous vaginal delivery at term: a cross-sectional study. 61 54
19668329 2009
6
Using proteomics in perinatal and neonatal sepsis: hopes and challenges for the future. 61 54
19395960 2009
7
Inflammatory cytokine mRNA detection by real time PCR in chorioamniotic membranes from pregnant women with preterm premature rupture of membranes. 61 54
19272692 2009
8
Mechanisms of leukocyte accumulation and activation in chorioamnionitis: interleukin 1 beta and tumor necrosis factor alpha enhance colony stimulating factor 2 expression in term decidua. 54 61
19164476 2009
9
[Local expression of tumor necrosis factor-alpha on premature rupture of membranes]. 61 54
19669033 2009
10
Intra-amniotic LPS modulation of TLR signaling in lung and blood monocytes of fetal sheep. 61 54
19318420 2009
11
Lipopolysaccharide binding protein in the early diagnosis of intraamniotic infection of pregnant women with premature rupture of the membranes. 61 54
18783308 2009
12
Uncultivated bacteria as etiologic agents of intra-amniotic inflammation leading to preterm birth. 54 61
18971361 2009
13
Value of amniotic fluid interleukin-8 for the prediction of histological chorioamnionitis in preterm premature rupture of membranes. 54 61
20038922 2009
14
[Relationship among TNF-alpha gene promoter -308 site polymorphism, the levels of maternal serum TNF-alpha, and the mRNA expression placental TNF-alpha in preterm labor]. 61 54
19292050 2009
15
Fetal umbilical cord blood erythropoietin, interleukin-6, pH, pO(2), pCO(2), and base excess levels in histologic and/or clinical chorioamnionitis: is the response only inflammatory? 61 54
19842878 2009
16
[The assessment of neutrophil elastase measurements usefulness in pregnant women with premature rupture of fetal membranes and chorioamnionitis suspicion]. 54 61
19323055 2009
17
Severe neonatal hypoxic respiratory failure correlates with histological chorioamnionitis and raised concentrations of interleukin 6 (IL6), IL8 and C-reactive protein. 61 54
18192328 2008
18
First-trimester maternal plasma concentrations of C-reactive protein in low-risk patients and the subsequent development of chorioamnionitis. 54 61
18938289 2008
19
Haplotypes of tumor necrosis factor gene and tracheal aspirate fluid levels of tumor necrosis factor-alpha in preterm infants. 54 61
18645461 2008
20
Interleukin-6 polymorphism is associated with chorioamnionitis and neonatal infections in preterm infants. 54 61
18571528 2008
21
Nucleated red blood cells are a direct response to mediators of inflammation in newborns with early-onset neonatal sepsis. 61 54
18395034 2008
22
[Cord blood levels of interleukin 6 in preterm infants as an early marker of neonatal morbidity]. 61 54
18358131 2008
23
Using proteomic analysis of the human amniotic fluid to identify histologic chorioamnionitis. 54 61
18238979 2008
24
Fetal cortisol response to intrauterine microbial colonisation identified by the polymerase chain reaction and fetal inflammation. 54 61
17405871 2008
25
Increased production of beta-defensin 3 (hBD-3) by human amniotic epithelial cells (HAEC) after activation of toll-like receptor 4 in chorioamnionitis. 61 54
18345485 2008
26
Progestin-inflammatory cytokine interactions affect matrix metalloproteinase-1 and -3 expression in term decidual cells: implications for treatment of chorioamnionitis-induced preterm delivery. 61 54
17940116 2008
27
WITHDRAWN: Oxytocin for prelabour rupture of membranes at or near term. 54 61
17636608 2007
28
Use of C-reactive protein as a predictor of chorioamnionitis in preterm prelabour rupture of membranes: a systematic review. 54 61
17567416 2007
29
WITHDRAWN: Prostaglandins versus oxytocin for prelabour rupture of membranes at term. 61 54
17636610 2007
30
WITHDRAWN: Prostaglandins versus oxytocin for prelabour rupture of membranes at or near term. 54 61
17636609 2007
31
Maternal serum proinflammatory cytokines in preterm labor with intact membranes: neonatal outcome and histological associations. 61 54
17594943 2007
32
Perfusion with lipopolysaccharide differently affects the secretion of tumor necrosis factor-alpha and interleukin-6 by term and preterm human placenta. 61 54
17194482 2007
33
LPS induces translocation of TLR4 in amniotic epithelium. 61 54
17055575 2007
34
Maternal plasma interleukin-6, interleukin-1beta and C-reactive protein as indicators of tocolysis failure and neonatal outcome after preterm delivery. 61 54
17437242 2007
35
Toll-like receptor-2 expression in normal and pathologic human placenta. 54 61
17239937 2007
36
Impact of subclinical chorioamnionitis on maternal and neonatal outcomes. 54 61
17364282 2007
37
IL-6 is constitutively expressed during lung morphogenesis and enhances fetal lung explant branching. 54 61
16988192 2006
38
Delivery outcome after cold-knife conization of the uterine cervix. 61 54
16750257 2006
39
Dermatitis as a component of the fetal inflammatory response syndrome is associated with activation of Toll-like receptors in epidermal keratinocytes. 54 61
17064297 2006
40
Role of single nucleotide polymorphisms of cytokine genes in spontaneous preterm delivery. 54 61
17145371 2006
41
The Alabama preterm birth study: corticosteroids and neonatal outcomes in 23- to 32-week newborns with various markers of intrauterine infection. 61 54
17000235 2006
42
Tumor necrosis factor-alpha and interleukin-1beta regulate interleukin-8 expression in third trimester decidual cells: implications for the genesis of chorioamnionitis. 61 54
17003486 2006
43
[Chorioamnionitis in relation to cord blood sICAM-1 and CRP levels of newborns with and without markers of early onset infection]. 61 54
17426373 2006
44
The value of cord blood interleukin-6 levels for predicting chorioamnionitis, funisitis and neonatal infection in term premature rupture of membranes. 61 54
16459014 2006
45
Tumour necrosis factor-alpha converting enzyme in human gestational tissues from pregnancies complicated by chorioamnionitis. 61 54
16376986 2006
46
Predictors of cesarean section following elective post-dates induction of labor in nullipara with uncomplicated singleton vertex pregnancies. 61 54
16883446 2006
47
Multiplex measurement of cytokine/receptor gene polymorphisms and interaction between interleukin-10 (-1082) genotype and chorioamnionitis in extreme preterm delivery. 61 54
16814164 2006
48
Intrauterine inflammation and the onset of peri-intraventricular hemorrhage in premature infants. 61 54
16549908 2006
49
Acute and chronic chorioamnionitis and the risk of perinatal human immunodeficiency virus-1 transmission. 54 61
16389028 2006
50
Amniotic fluid neutrophil elastase and lactate dehydrogenase: association with histologic chorioamnionitis. 61 54
16752257 2006
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Variations for Chorioamnionitis

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Expression for Chorioamnionitis

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Search GEO for disease gene expression data for Chorioamnionitis.
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Pathways for Chorioamnionitis

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Pathways related to Chorioamnionitis according to GeneCards Suite gene sharing:

(show top 50) (show all 89)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 14 VEGFA TREM1 TNF TLR4 S100A12 MMP9
2
ERK Signaling 63
Show member pathways
 13.94 VEGFA TNF IL6 IL1R1 IL1B IL1A
3
PEDF Induced Signaling 63
Show member pathways
 13.8 TNF TLR4 IL6 IL1RN IL1R1 IL1B
4
TGF-Beta Pathway 63
Show member pathways
 13.68 VEGFA TNF IL6 IL1R1 IL1B IL1A
5
Akt Signaling 63
Show member pathways
 13.54 TNF TLR4 IL6 IL1R1 IL1B IL1A
6
Cytokine Signaling in Immune system 65
Show member pathways
 13.47 VEGFA TNF MMP9 IL6 IL1RN IL1R1
7
PAK Pathway 63
Show member pathways
 13.44 TNF IL6 IL1R1 IL1B IL1A IL18
8
Toll-like Receptor Signaling Pathway 36 1
Show member pathways
 13.2 TREM1 TNF TLR4 MMP9 IL6 IL1B
9
Human cytomegalovirus infection 36
Show member pathways
 13.08 VEGFA TNF TLR4 IL6 IL1R1 IL1B
10
Allograft rejection 1 36
Show member pathways
 13 VEGFA TNF IL6 IL1B IL1A IL10
11
Measles 36
Show member pathways
 12.97 TNF TLR4 IL6 IL1B IL1A IL18
12
MAPK signaling pathway 36 1
12.89 VEGFA TNF IL1R1 IL1B IL1A FLT1
13
NF-KappaB Family Pathway 63
Show member pathways
 12.87 TNF TLR4 IL6 IL1R1 IL1B IL1A
14
Toll-Like receptor Signaling Pathways 64
Show member pathways
 12.86 TNF TLR4 IL6 IL1RN IL1R1 IL1B
15
Th17 cell differentiation 36
Show member pathways
 12.77 TNF TLR4 IL6 IL1R1 IL1B IL1A
16
T cell receptor signaling pathway 36
Show member pathways
 12.74 TNF TLR4 IL6 IL1B IL1A IL10
17
Immune response IL-23 signaling pathway 22
Show member pathways
 12.73 TNF IL6 IL1B IL18 IL10 CCL2
18
TRAF Pathway 63
Show member pathways
 12.69 TNF TLR4 IL1R1 IL1B IL1A
19
NF-kappaB Signaling 4
12.67 TNF IL1RN IL1B IL10 CCL2
20
Shigellosis 36
12.57 TNF TLR4 IL1R1 IL1B IL18 CXCL8
21
IL-17 Family Signaling Pathways 64
Show member pathways
 12.5 TNF MMP9 IL6 IL1B CXCL8 CCL2
22
Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions 64
Show member pathways
 12.5 TNF IL6 IL18 IL10 CXCL8 CCL2
23
Toll Comparative Pathway 63
Show member pathways
 12.49 TNF TLR4 IL6 IL1R1 IL1B IL1A
24
Folate Metabolism 1
Show member pathways
 12.47 TNF IL6 IL1B CRP CCL2
25
Salmonella infection (KEGG) 36
12.47 TNF TLR4 IL6 IL1B IL18 CXCL8
26
IL-1 signaling pathway 1
Show member pathways
 12.44 IL1RN IL1R1 IL1B IL1A CCL2
27
Pathogenic Escherichia coli infection 36
12.44 TNF TLR4 IL6 IL1R1 IL1B IL18
28
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 12.43 TNF IL6 IL1B IL1A IL18 IL10
29
Transcriptional misregulation in cancer 36
12.42 MMP9 IL6 FLT1 ELANE CXCL8
30
Diseases associated with the TLR signaling cascade 65
Show member pathways
 12.41 TNF TLR4 IL6 IL1A CXCL8
31
NOD-like receptor signaling pathway 36
12.41 TNF TLR4 IL6 IL1B IL18 CXCL8
32
Toxoplasmosis 36
Show member pathways
 12.4 TNF TLR4 IL1B IL1A IL10
33
Tuberculosis 36
12.4 TNF TLR4 IL6 IL1B IL1A IL18
34
Proteoglycans in cancer 36
12.38 VEGFA TNF TLR4 MMP9
35
Bacterial infections in CF airways 22
Show member pathways
 12.36 TNF TLR4 IL6 IL1R1 IL1B CXCL8
36
Colorectal Cancer Metastasis 63
12.34 VEGFA TNF TLR4 MMP9 IL6
37
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.31 VEGFA TNF IL6 IL1RN IL1B IL1A
38
C-type lectin receptor signaling pathway 36
Show member pathways
 12.3 TNF IL6 IL1B IL10
39
Necroptosis 36
Show member pathways
 12.29 TNF TLR4 IL1B IL1A
40
Fluid shear stress and atherosclerosis 36
12.24 VEGFA TNF MMP9 IL1R1 IL1B IL1A
41
Osteoclast differentiation 36
12.16 TNF IL1R1 IL1B IL1A
42
MAPK Pathway 70
Show member pathways
 12.15 TLR4 IL1R1 IL1B IL1A
43
TNF signaling pathway 36
12.15 TNF MMP9 IL6 IL1B CCL2
44
IL27-mediated signaling events 1
Show member pathways
 12.14 TNF TLR4 IL6 IL1B IL18 IL10
45
NF-kappa B signaling pathway 36
12.12 TNF TLR4 IL1R1 IL1B CXCL8
46
HIF-1 signaling pathway 36
12.09 VEGFA TLR4 IL6 FLT1
47
Hematopoietic cell lineage 36
12.09 TNF IL6 IL1R1 IL1B IL1A
48
Amoebiasis 36
12.08 TNF TLR4 IL6 IL1R1 IL1B IL10
49
Senescence and Autophagy in Cancer 1
12.07 IL6 IL1B IL1A CXCL8
50
AGE-RAGE signaling pathway in diabetic complications 36
12.05 VEGFA TNF IL6 IL1B IL1A CXCL8
Sources

GO Terms for Chorioamnionitis

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Cellular components related to Chorioamnionitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.86 VEGFA TNF OXT MMP9 MMP8 IL6
2 extracellular region GO:0005576 9.6 VEGFA TREM1 TNF S100A12 OXT MMP9
3 secretory granule GO:0030141 9.46 VEGFA OXT IL1B ELANE

Biological processes related to Chorioamnionitis according to GeneCards Suite gene sharing:

(show top 50) (show all 75)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.33 VEGFA TLR4 OXT IL6 IL1RN IL1R1
2 positive regulation of transcription by RNA polymerase II GO:0045944 10.28 VEGFA TNF TLR4 IL6 IL1B IL1A
3 negative regulation of cell proliferation GO:0008285 10.14 IL6 IL1B IL1A IL10 CXCL8
4 defense response to bacterium GO:0042742 10.08 TNF TLR4 S100A12 IL10 ELANE
5 angiogenesis GO:0001525 10.07 VEGFA IL18 FLT1 CXCL8 CCL2
6 leukocyte migration GO:0050900 10.04 TREM1 TNF IL1B ELANE
7 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 10.04 TNF TLR4 S100A12 IL1B IL1A
8 positive regulation of protein phosphorylation GO:0001934 10.03 VEGFA TNF MMP9 IL1B
9 response to lipopolysaccharide GO:0032496 10.03 TLR4 IL1B IL10 ELANE
10 positive regulation of gene expression GO:0010628 10.02 VEGFA TNF TLR4 MMP8 IL6 IL1B
11 positive regulation of angiogenesis GO:0045766 10 VEGFA IL1B IL1A FLT1 CXCL8
12 positive regulation of NF-kappaB transcription factor activity GO:0051092 10 TNF TLR4 S100A12 IL6 IL1B IL18
13 positive regulation of DNA-binding transcription factor activity GO:0051091 9.99 TNF IL6 IL1B IL10
14 interleukin-1-mediated signaling pathway GO:0070498 9.97 IL1RN IL1R1 IL1B IL1A
15 positive regulation of JNK cascade GO:0046330 9.96 TNF TLR4 MMP8 IL1B
16 neutrophil chemotaxis GO:0030593 9.95 S100A12 IL1B CXCL8 CCL2
17 positive regulation of inflammatory response GO:0050729 9.95 TNF TLR4 S100A12 IL1B IL18
18 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.94 VEGFA TNF IL6 IL18
19 cellular response to organic cyclic compound GO:0071407 9.93 TNF IL1B IL18 CCL2
20 extracellular matrix disassembly GO:0022617 9.92 MMP9 MMP8 ELANE
21 positive regulation of smooth muscle cell proliferation GO:0048661 9.92 TNF IL6 IL18 ELANE
22 cellular response to lipopolysaccharide GO:0071222 9.92 TNF TLR4 IL6 IL1B IL1A IL10
23 humoral immune response GO:0006959 9.91 TREM1 TNF IL6 CCL2
24 response to glucocorticoid GO:0051384 9.91 TNF OXT IL6 IL1RN IL10
25 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.9 TNF MMP9 IL10
26 positive regulation of cell division GO:0051781 9.9 VEGFA IL1B IL1A
27 immune response GO:0006955 9.9 TNF TLR4 IL6 IL1RN IL1R1 IL1B
28 protein kinase B signaling GO:0043491 9.89 TNF IL1B CCL2
29 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.89 TNF IL1B IL1A
30 negative regulation of interleukin-6 production GO:0032715 9.89 TNF TLR4 IL10
31 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.89 TNF TLR4 MMP8 IL1B IL18
32 monocyte chemotaxis GO:0002548 9.88 S100A12 IL6 FLT1 CCL2
33 positive regulation of MAP kinase activity GO:0043406 9.88 VEGFA TNF S100A12 FLT1 ELANE
34 positive regulation of cytokine secretion GO:0050715 9.87 TNF IL1A IL10
35 positive regulation of JAK-STAT cascade GO:0046427 9.87 TNF IL6 IL10
36 positive regulation of interleukin-8 production GO:0032757 9.87 TNF TLR4 IL1B
37 positive regulation of nitric oxide biosynthetic process GO:0045429 9.87 TNF TLR4 MMP8 IL1B
38 positive regulation of vascular endothelial growth factor production GO:0010575 9.86 IL6 IL1B IL1A
39 positive regulation of interleukin-6 secretion GO:2000778 9.86 TNF TLR4 IL1B IL1A
40 negative regulation of neurogenesis GO:0050768 9.85 TNF IL6 IL1B
41 inflammatory response to antigenic stimulus GO:0002437 9.85 IL1RN IL1B IL1A
42 positive regulation of interleukin-6 production GO:0032755 9.85 TNF TLR4 MMP8 IL6 IL1B
43 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.84 TNF TLR4 IL6
44 positive regulation of chemokine production GO:0032722 9.83 TNF TLR4 IL6
45 positive regulation of glial cell proliferation GO:0060252 9.83 TNF IL6 IL1B
46 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.83 VEGFA IL1B FLT1
47 positive regulation of interferon-gamma production GO:0032729 9.83 TNF TLR4 IL1R1 IL1B IL18
48 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.81 TNF IL1B IL10
49 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.8 TNF TLR4 ELANE
50 lipopolysaccharide-mediated signaling pathway GO:0031663 9.8 TNF TLR4 IL1B IL18 CCL2

Molecular functions related to Chorioamnionitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.32 VEGFA TNF IL6 IL1RN IL1B IL1A
2 interleukin-1 receptor binding GO:0005149 9.13 IL1RN IL1B IL1A
Sources

Sources for Chorioamnionitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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