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MCID: CHR005
MIFTS: 51

Chorioamnionitis

Categories: Fetal diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Chorioamnionitis

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MalaCards integrated aliases for Chorioamnionitis:

Name: Chorioamnionitis 12 55 15 73

Classifications:

MalaCards categories:
Global: Fetal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:0050697
UMLS 73 C0008495
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Summaries for Chorioamnionitis

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Disease Ontology : 12 A placenta disease that is an inflammation of the fetal membranes (amnion and chorion) due to a bacterial infection.

MalaCards based summary : Chorioamnionitis is related to funisitis and preterm premature rupture of the membranes. An important gene associated with Chorioamnionitis is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Dinoprostone and Clindamycin have been mentioned in the context of this disorder. Affiliated tissues include placenta, brain and uterus, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 76 Chorioamnionitis also known as intra-amniotic infection (IAI) is an inflammation of the fetal membranes... more...

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Related Diseases for Chorioamnionitis

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Diseases related to Chorioamnionitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 345)
# Related Disease Score Top Affiliating Genes
1 funisitis 31.6 CXCL8 IL1B IL6
2 preterm premature rupture of the membranes 31.6 CXCL8 IL6 MMP8
3 vaginitis 31.3 CXCL8 IL1B IL6
4 cerebral palsy 31.1 IL1B IL6 TNF
5 placenta disease 30.7 CXCL8 IL1B IL6 OXT
6 haemophilus influenzae 30.4 CXCL8 IL1B TNF
7 bronchopulmonary dysplasia 30.4 CXCL8 ELANE FLT1
8 endometritis 30.4 IL1B IL6 OXT TNF
9 endometriosis 30.1 CCL2 CXCL8 IL6
10 eclampsia 30.0 FLT1 OXT TNF
11 bacteriuria 29.8 CXCL8 IL6 TLR4
12 septic arthritis 29.7 CRP CXCL8 TLR4
13 pre-eclampsia 29.6 FLT1 IL6 OXT TNF
14 vasculitis 29.6 CCL2 CRP ELANE TNF
15 respiratory failure 29.4 CRP CXCL8 ELANE TNF
16 toxic shock syndrome 28.9 CXCL8 IL1B IL6 TLR4 TNF
17 otitis media 28.9 CXCL8 IL1B IL6 TLR4 TNF
18 pertussis 28.8 IL1A IL1B IL6 TLR4 TNF
19 crohn's disease 28.8 CRP IL1B IL6 TLR4 TNF
20 bacterial vaginosis 28.6 CXCL8 IL1A IL1B IL6 TLR4 TNF
21 lung disease 28.6 CCL2 CXCL8 ELANE IL1B MMP9 TNF
22 perinatal necrotizing enterocolitis 28.6 CRP CXCL8 IL1B IL6 TLR4 TNF
23 chlamydia 28.3 CRP CXCL8 IL1B IL6 TLR4 TNF
24 appendicitis 28.3 CRP CXCL8 IL1B IL6 MMP8 MMP9
25 arthritis 27.9 CCL2 CXCL8 IL1A IL1B IL6 MMP9
26 pneumonia 26.9 CCL2 CRP CXCL8 ELANE IL1B IL6
27 malaria 24.8 CCL2 CRP CXCL8 IL1A IL1B IL1R1
28 asthma 24.5 CCL2 CXCL8 ELANE IL1A IL1B IL1R1
29 listeriosis 11.0
30 scorpion envenomation 10.9 IL6 TNF
31 leukomalacia 10.9 IL6 TNF
32 angioimmunoblastic lymphadenopathy with dysproteinemia 10.9 IL6 TNF
33 critical limb ischemia 10.9 IL6 TNF
34 tungiasis 10.9 CXCL8 TNF
35 systemic onset juvenile idiopathic arthritis 10.9 IL1B TNF
36 staphylococcal toxic shock syndrome 10.8 IL1B TNF
37 null-cell leukemia 10.8 IL6 TNF
38 autoimmune myocarditis 10.8 IL1B TNF
39 cold agglutinin disease 10.8 CRP IL6
40 kashin-beck disease 10.8 IL1B TNF
41 leukoregulin 10.8 CXCL8 IL1A
42 retinitis pigmentosa 55 10.8 IL6 TNF
43 papillary conjunctivitis 10.7 CXCL8 IL6
44 skin conditions 10.7 IL1A TNF
45 scabies 10.7 CXCL8 IL1A
46 cardiogenic shock 10.7 CRP IL6
47 acute cholangitis 10.7 CRP IL6
48 slow-channel congenital myasthenic syndrome 10.7 CRP CXCL8
49 streptococcal toxic-shock syndrome 10.7 CXCL8 IL6 TNF
50 anca-associated vasculitis 10.7 IL6 TNF

Graphical network of the top 20 diseases related to Chorioamnionitis:



Diseases related to Chorioamnionitis
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Symptoms & Phenotypes for Chorioamnionitis

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MGI Mouse Phenotypes related to Chorioamnionitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.07 CRP IL6 FLT1 MMP9 IL1A OXT
2 homeostasis/metabolism MP:0005376 10.03 CRP IL6 ELANE FLT1 MMP8 MMP9
3 hematopoietic system MP:0005397 9.97 IL1R1 IL6 ELANE FLT1 MMP9 IL1A
4 immune system MP:0005387 9.93 CRP IL6 ELANE FLT1 MMP8 MMP9
5 integument MP:0010771 9.56 IL6 MMP9 IL1A OXT IL1B TLR4
6 neoplasm MP:0002006 9.28 IL6 ELANE MMP8 MMP9 IL1A IL1B
Sources

Drugs & Therapeutics for Chorioamnionitis

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Drugs for Chorioamnionitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 156)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dinoprostone Approved Phase 4,Phase 3,Not Applicable 363-24-6 5280360
2
Clindamycin Approved, Vet_approved Phase 4,Not Applicable 18323-44-9 29029
3
Misoprostol Approved Phase 4,Phase 2,Not Applicable 59122-46-2 5282381
4
Oxytocin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-56-6 439302 53477758
5
Ampicillin Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 69-53-4 6249
6
Progesterone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 57-83-0 5994
7
Cefuroxime Approved Phase 4 55268-75-2 5361202 5479529
8
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
9
Azithromycin Approved Phase 4 83905-01-5 55185 447043
10
Povidone-iodine Approved Phase 4,Not Applicable 25655-41-8
11
Glucosamine Approved, Investigational, Nutraceutical Phase 4 3416-24-8 439213
12 Oxytocics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
13 Anti-Bacterial Agents Phase 4,Phase 2,Phase 3,Not Applicable
14 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
15 Clindamycin palmitate Phase 4,Not Applicable
16 Clindamycin phosphate Phase 4,Not Applicable
17 Antacids Phase 4,Phase 2,Not Applicable
18 Anti-Ulcer Agents Phase 4,Phase 2,Not Applicable
19 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Not Applicable
20 Anesthetics Phase 4,Phase 3,Not Applicable
21 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Not Applicable
22 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Not Applicable
23 Antitubercular Agents Phase 4,Phase 2,Phase 3,Not Applicable
24 Analgesics Phase 4,Phase 3,Phase 2,Not Applicable
25 Gentamicins Phase 4,Phase 2,Phase 3,Not Applicable
26 Adjuvants, Anesthesia Phase 4
27 Anticonvulsants Phase 4,Phase 3
28 Autonomic Agents Phase 4,Phase 2,Phase 3
29 Bromides Phase 4
30 Butylscopolammonium Bromide Phase 4
31 Cholinergic Agents Phase 4
32 Cholinergic Antagonists Phase 4
33 Muscarinic Antagonists Phase 4
34 Mydriatics Phase 4
35 Neurotransmitter Agents Phase 4
36 Parasympatholytics Phase 4
37 Scopolamine hydrobromide Phase 4 114-49-8
38 Hormone Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
39 Hormones Phase 4,Phase 3,Phase 2,Not Applicable
40 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
41 Progestins Phase 4,Phase 3,Phase 2,Not Applicable
42 Pharmaceutical Solutions Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
43 cefuroxime axetil Phase 4
44 Anticoagulants Phase 4
45 Antimetabolites Phase 4
46 Fibrinolytic Agents Phase 4
47 Glucuronyl glucosamine glycan sulfate Phase 4
48 Hypoglycemic Agents Phase 4
49 Hypolipidemic Agents Phase 4
50 Lipid Regulating Agents Phase 4

Interventional clinical trials:

(show top 50) (show all 166)
# Name Status NCT ID Phase Drugs
1 A Trial of Prostaglandin E2 Tablets Versus Foley Catheter for Labor Induction Unknown status NCT02486679 Phase 4 Prostin (PGE2) tablets
2 Prevention of Very Preterm Delivery by Testing for and Treatment of Bacterial Vaginosis Completed NCT00642980 Phase 4 Clindamycin;Placebo;Clindamycin
3 Randomized Trial Comparing Misoprostol and Foley Bulb for Pregnancy Termination in the Second Trimester Completed NCT00324519 Phase 4 misoprostol
4 Safety Study of Hyoscine N Butyl Bromide in Active Management of Labor Completed NCT02098889 Phase 4 hyoscine-N-butyl bromide(HBB);Saline
5 Oxytocin Regimen to Prevent Atony and Postpartum Hemorrhage During Vaginal Delivery: 3-arm RCT Completed NCT00790062 Phase 4 Oxytocin
6 A Trial of Oral Misoprostol for Labor Augmentation Completed NCT00906347 Phase 4 Misoprostol;Oxytocin
7 Prevention of Preterm Birth in Pregnant Women at Risk Identified by Ultrasound: Evaluation of Two Treatment Strategies Completed NCT01643980 Phase 4 Vaginal micronized progesterone
8 Induction of Labor With a Foley Balloon Catheter: Inflation With 30ml Compared to 60ml Completed NCT00451308 Phase 4
9 Comparison of Two Antibiotic Prophylactic Protocols in Preterm Premature Rupture of the Membranes Recruiting NCT02819570 Phase 4 I.V cefuroxime 750 mg*3/d for 2 days;I.V ampicillin 2 gram x4/d for 2 days;P.O cefuroxime 500 mgx2/d for 5 days;P.O roxithromycin 150 mg*2/d for 7 days;P.O moxypen 500 mgx3/d for 5 days
10 Intrapartum Fever: Antibiotics Versus no Treatment Recruiting NCT03168178 Phase 4 Standard Antibiotic Treatment
11 Antibiotic Prophlaxis for High-risk Laboring Women in Low Income Countries Recruiting NCT03248297 Phase 4 Azithromycin;Azithromycin and amoxicillin;Placebo
12 Cervical Cerclage for Preventing Spontaneous Preterm Birth in Singleton Pregnancies Without Prior Spontaneous Preterm Birth and With Short Transvaginal Ultrasound Cervical Length Recruiting NCT02746900 Phase 4
13 Comparison of Low-dose and High-dose Oxytocin Regimens for Labor Augmentation Recruiting NCT02487797 Phase 4 Oxytocin
14 Cervical Ripening for Obese Women: A Randomized, Comparative Effectiveness Trial Recruiting NCT02639429 Phase 4 Vaginal Misoprostol
15 Foley Bulb With Oral Misoprostol for Induction of Labor Recruiting NCT03407625 Phase 4
16 A Comparison of Oral Misoprostol and Vaginal Misoprostol for Cervical Ripening and Induction of Labor Recruiting NCT02777190 Phase 4 Misoprostol
17 Cook Balloon Versus Propess After 12 Hours of Rupture of Membranes Recruiting NCT03310333 Phase 4 Propess® (dinoprostone)
18 The Obese Pitocin Study Recruiting NCT03140488 Phase 4 Oxytocin
19 TRAP Intervention STudy: Early Versus Late Intervention for Twin Reversed Arterial Perfusion Sequence Recruiting NCT02621645 Phase 4
20 Safety and Immunogenicity of Simultaneous Tdap and IIV in Pregnant Women Active, not recruiting NCT02783170 Phase 4
21 Treatment Utility of Postpartum Antibiotics in Chorioamnionitis Terminated NCT01585129 Phase 4 Postpartum Antibiotics;No postpartum antibiotics
22 Removal Versus Retention of Cerclage in Preterm Premature Rupture of Membranes (PPROM) Terminated NCT00201656 Phase 4
23 Buccal Versus Vaginal Misoprostol for Third Trimester Induction of Labor Terminated NCT01519765 Phase 4 Buccal Misoprostol;Vaginal misoprostol
24 Bacterial Vaginosis Screening and Treatment to Reduce Infective Complications, Abortion and Preterm Delivery Unknown status NCT00491270 Phase 3
25 Trial of AMNIOECHANGE in Gastroschisis Affected Foetuses Unknown status NCT00127946 Phase 3
26 Pessary as Adjunctive Therapy to Cerclage for the Prevention of Preterm Birth Unknown status NCT02678026 Phase 3
27 Ampicillin / Sulbactam vs. Ampicillin / Gentamicin for Treatment of Chorioamnionitis Completed NCT00879190 Phase 2, Phase 3 Unasyn;Ampicillin/gentamicin
28 Antibiotics to Reduce Chorioamnionitis-Related Perinatal HIV Transmission Completed NCT00021671 Phase 3 Erythromycin;Nevirapine;Ampicillin sodium;Metronidazole
29 Antibiotic Prophylaxis in Prelabor Rupture of Membranes at Term Completed NCT01633294 Phase 2, Phase 3 Ampicillin + gentamicin
30 Antibiotics Study in Preterm Premature Rupture of the Membranes Completed NCT01401179 Phase 3 cefazolin, erythromycin, clarithromycin
31 Combined Anesthesia for Labor and Maternal Temperature Completed NCT01078519 Phase 3 Combined epidural and spinal anesthesia
32 Induction of Labor in Term Premature Rupture of Membranes: A Comparison Between Oxytocin and Dinoprostone Followed Six Hours Later by Oxytocin Completed NCT01099280 Phase 3 SYNPITAN FORT 5 IU;Propess,SYNPITAN FORT
33 Chlorhexidine Vaginal and Infant Wash in Pakistan Completed NCT00121394 Phase 3
34 Does Vitamins C and E Supplementation of After Preterm Rupture of Membranes Prolong the Duration of Latency? A Prospective Randomized Controlled Study Completed NCT01266928 Phase 3 vitamine C and E
35 Pessary in Singleton Gestations With Short Cervix Without Prior Preterm Birth Completed NCT02716909 Phase 3
36 Fetal ST Segment and T Wave Analysis in Labor Completed NCT01131260 Phase 3
37 Beneficial Effects of Antenatal Magnesium Sulfate (BEAM Trial) Completed NCT00014989 Phase 3 magnesium sulfate
38 Trial of Progesterone in Twins and Triplets to Prevent Preterm Birth (STTARS) Completed NCT00099164 Phase 3 17 alpha-hydroxyprogesterone caproate (17P)
39 Reduction of Spontaneous Prematurity by Antibiotic Treatment (Josamycin) Completed NCT00718705 Phase 3 Josamycin;Placebo
40 Cerclage for Singletons With Short Cervix Without Prior Preterm Birth Recruiting NCT02716922 Phase 3
41 Effects of ACS in Twin With LPB: Study Protocol for a RCT Recruiting NCT03547791 Phase 2, Phase 3 Betamethason Sodium Phosphate;Normal saline
42 Does a Rescue Course of Betamethasone in Pregnant Women With PPROM Decrease Neonatal Morbidity? Recruiting NCT02939742 Phase 2, Phase 3 Betamethasone;Placebo
43 Impact of a Booster Course of Antenatal Steroids on Neonatal Outcome in Patients With Premature Rupture of the Membranes Recruiting NCT02469519 Phase 2, Phase 3 Betamethasone - ACTIVE
44 Antenatal Late Preterm Steroids (ALPS): A Randomized Placebo-Controlled Trial Active, not recruiting NCT01222247 Phase 3 Betamethasone 3 MG/ML;Placebo
45 Oral Probiotic Supplementation in Pregnancy to Reduce Group B Streptococcus Colonization Not yet recruiting NCT03407157 Phase 3
46 Progesterone for Maintenance Tocolysis: A Randomized Placebo Controlled Trial Terminated NCT00946088 Phase 2, Phase 3 Progesterone;Polyethylene glycol&hydrogenated vegetable oil.
47 A Phase III Efficacy and Safety Study of Intravenous Retosiban Versus Placebo for Women in Spontaneous Preterm Labor Terminated NCT02377466 Phase 3 Retosiban IV infusion;Placebo IV infusion
48 Can Safety Planning Improve Perinatal Outcomes Among Pregnant Women Exposed to Intimate Partner Violence? Withdrawn NCT00831831 Phase 3
49 Indomethacin Versus Placebo in Women With Preterm Premature Rupture of Membranes (PPROM) Unknown status NCT00466128 Phase 2 indomethacin
50 Prehospital Cervical Ripening Before Induction and the Maternal Experience Unknown status NCT01641601 Phase 1, Phase 2

Search NIH Clinical Center for Chorioamnionitis

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Genetic Tests for Chorioamnionitis

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Anatomical Context for Chorioamnionitis

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MalaCards organs/tissues related to Chorioamnionitis:

41
Placenta, Brain, Uterus, Lung, Testes, Colon, Cervix
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Publications for Chorioamnionitis

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Articles related to Chorioamnionitis:

(show top 50) (show all 706)
# Title Authors Year
1
Association of Histologic Chorioamnionitis With Perinatal Brain Injury and Early Childhood Neurodevelopmental Outcomes Among Preterm Neonates. ( 29610829 )
2018
2
Incidence of early-onset sepsis in infants born to women with clinical chorioamnionitis. ( 29791315 )
2018
3
The expression of Toll-like receptor 5 in preterm histologic chorioamnionitis. ( 29371755 )
2018
4
Histologic chorioamnionitis in preterm infants: correlation with brain magnetic resonance imaging at term equivalent age. ( 29448926 )
2018
5
Impact of histologic chorioamnionitis on pulmonary hypertension and respiratory outcomes in preterm infants. ( 29480140 )
2018
6
Chorioamnionitis exposure dampens the preterm monocyte response to subsequent challenges. ( 29931696 )
2018
7
Parallel detection of lactobacillus and bacterial vaginosis-associated bacterial DNA in the chorioamnion and vagina of pregnant women at term. ( 29478370 )
2018
8
Suspected Chorioamnionitis and Myometrial Contractility: Mechanisms for Increased Risk of Cesarean Delivery and Postpartum Hemorrhage. ( 29848185 )
2018
9
Persistent Pulmonary Hypertension and Histologic Chorioamnionitis in Preterm Infants: Controlled Study. ( 29453682 )
2018
10
Prediction of histological chorioamnionitis and neonatal and infantile outcomes using procalcitonin in the umbilical cord blood and amniotic fluid at birth. ( 29315994 )
2018
11
Case Report: Chorioamnionitis and Premature Delivery due to<i>Burkholderia pseudomallei</i>Infection in Pregnancy. ( 29363450 )
2018
12
Intrapartum Management of Chorioamnionitis. ( 29215424 )
2018
13
Daily gentamicin using ideal body weight demonstrates lower risk of postpartum endometritis and increased chance of successful outcome compared with traditional 8-hour dosing for the treatment of intrapartum chorioamnionitis. ( 29642754 )
2018
14
Concurrent intraoperative uterine rupture and placenta accreta. Do preoperative chronic hypertension, preterm premature rupture of membranes, chorioamnionitis, and placental abruption provide warning to this rare occurrence? ( 29756067 )
2018
15
Chorioamnionitis, neuroinflammation, and injury: timing is key in the preterm ovine fetus. ( 29673373 )
2018
16
Exposure to chorioamnionitis alters the monocyte transcriptional response to the neonatal pathogen Staphylococcus epidermidis. ( 29533486 )
2018
17
The Consequences of Preterm Birth and Chorioamnionitis on Brainstem Respiratory Centers: Implications for Neurochemical Development and Altered Functions by Inflammation and Prostaglandins. ( 29449803 )
2018
18
Chorioamnionitis Induces a Specific Signature of Placental ABC Transporters Associated with an Increase of miR-331-5p in the Human Preterm Placenta. ( 29402780 )
2018
19
Validation of diagnostic tests for histologic chorioamnionitis: Systematic review and meta-analysis. ( 29908373 )
2018
20
The change of fetal heart rate short-term variability during the course of histological chorioamnionitis in fetal sheep. ( 29908375 )
2018
21
Clinical Monitoring of Well-Appearing Infants Born to Mothers With Chorioamnionitis. ( 29599112 )
2018
22
Subclinical and clinical chorioamnionitis, fetal vasculitis, and risk for preterm birth: A cohort study. ( 29941174 )
2018
23
In response: Is early onset sepsis risk calculator safe for the management of neonates born to mothers with chorioamnionitis? ( 29795323 )
2018
24
Case report of Staphylococcus epidermidis maternal sepsis and chorioamnionitis following fetoscopy. ( 29055131 )
2018
25
Increased miR-223 expression in foetal organs is a signature of acute chorioamnionitis with systemic consequences. ( 29083107 )
2018
26
Does maternal chorioamnionitis have to equal antibiotics in an asymptomatic infant? ( 29887607 )
2018
27
Discharge breastmilk feeding rates in asymptomatic term newborns admitted to the neonatal intensive care unit for maternal chorioamnionitis. ( 29526120 )
2018
28
Maternal Serum Interleukin-6: A Non-Invasive Predictor of Histological Chorioamnionitis in Women with Preterm-Prelabor Rupture of Membranes. ( 29635237 )
2018
29
Antenatal Vitamin D Preserves Placental Vascular and Fetal Growth in Experimental Chorioamnionitis Due to Intra-amniotic Endotoxin Exposure. ( 29715698 )
2018
30
Is early-onset sepsis risk calculator safe for the management of neonates born to mothers with chorioamnionitis? ( 29467522 )
2018
31
Neutrophil extracellular traps in acute chorioamnionitis: AA mechanism of host defense. ( 28045214 )
2017
32
Genital tract GBS and rate of histologic chorioamnionitis in patients with preterm premature rupture of membrane. ( 28715920 )
2017
33
Urinary metabolomic analysis to identify preterm neonates exposed to histological chorioamnionitis: A pilot study. ( 29211784 )
2017
34
Quality and Clinical Outcomes Associated with a Gentamicin Use System Change for Managing Chorioamnionitis. ( 29124501 )
2017
35
Utility of Early-Onset Sepsis Risk Calculator for Neonates Born to Mothers with Chorioamnionitis. ( 29275925 )
2017
36
Chorioamnionitis: Is a major player in the development of bronchopulmonary dysplasia? ( 28861110 )
2017
37
Chorioamnionitis in the Development of Cerebral Palsy: A Meta-analysis and Systematic Review. ( 28814548 )
2017
38
Histological Chorioamnionitis as a Risk Factor for Preterm Birth without Disturbing Fetal Heart Rate: A Case-Control Study. ( 29249732 )
2017
39
Bacterial communities found in placental tissues are associated with severe chorioamnionitis and adverse birth outcomes. ( 28700642 )
2017
40
Histologic chorioamnionitis does not modulate the oxidative stress and antioxidant status in pregnancies complicated by spontaneous preterm delivery. ( 29132320 )
2017
41
The Human Ureaplasma Species as Causative Agents of Chorioamnionitis. ( 27974410 )
2017
42
Association of histological chorioamnionitis and magnesium sulfate treatment in singleton and dichorionic twin pregnancies with preterm premature rupture of membranes: preliminary observations. ( 28873067 )
2017
43
High- but not low-grade histologic chorioamnionitis is associated with spontaneous preterm birth in a Swedish cohort. ( 28605945 )
2017
44
Histologic Chorioamnionitis and Bronchopulmonary Dysplasia in Preterm Infants: The Epidemiologic Study on Low Gestational Ages 2 Cohort. ( 28583707 )
2017
45
<i>Candida</i> Chorioamnionitis Leads to Preterm Birth and Adverse Fetal-Neonatal Outcome. ( 29180840 )
2017
46
Chorioamnionitis, IL-17A, and fetal origins of neurologic disease. ( 29271527 )
2017
47
Chorioamnionitis and Management of Asymptomatic Infants a8Y35 Weeks Without Empiric Antibiotics. ( 28759393 )
2017
48
Intrauterine inflammation, infection, or both (Triple I): A new concept for chorioamnionitis. ( 29066072 )
2017
49
Maternal obesity is associated with chorioamnionitis and earlier indicated preterm delivery among expectantly managed women with preterm premature rupture of membranes. ( 28936902 )
2017
50
Chorioamnionitis following preterm premature rupture of membranes and fetal heart rate variability. ( 28945767 )
2017
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Variations for Chorioamnionitis

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Expression for Chorioamnionitis

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Search GEO for disease gene expression data for Chorioamnionitis.
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Pathways for Chorioamnionitis

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Pathways related to Chorioamnionitis according to GeneCards Suite gene sharing:

(show top 50) (show all 82)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 66
Show member pathways
 14.03 CCL2 CRP CXCL8 ELANE IL1A IL1B
2
ERK Signaling 64
Show member pathways
 13.83 CCL2 CXCL8 FLT1 IL1A IL1B IL1R1
3
PEDF Induced Signaling 64
Show member pathways
 13.7 CCL2 CXCL8 FLT1 IL1A IL1B IL1R1
4
TGF-Beta Pathway 64
Show member pathways
 13.54 CCL2 CXCL8 FLT1 IL1A IL1B IL1R1
5
Akt Signaling 64
Show member pathways
 13.45 CCL2 CXCL8 FLT1 IL1A IL1B IL1R1
6
Cytokine Signaling in Immune system 66
Show member pathways
 13.41 CCL2 CXCL8 IL1A IL1B IL1R1 IL6
7
PAK Pathway 64
Show member pathways
 13.35 CCL2 CXCL8 FLT1 IL1A IL1B IL1R1
8
Toll-like Receptor Signaling Pathway 37 1
Show member pathways
 13.05 CCL2 CXCL8 IL1B IL6 TLR4 TNF
9
Allograft rejection 1 37
Show member pathways
 12.89 CXCL8 IL1A IL1B IL6 TNF
10
Influenza A 37
Show member pathways
 12.87 CCL2 CXCL8 IL1A IL1B IL6 TLR4
11
IL-2 Pathway 64
Show member pathways
 12.82 IL1A IL1B IL1R1 TLR4 TNF
12
MAPK signaling pathway 1 37
12.8 FLT1 IL1A IL1B IL1R1 TNF
13
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways 66
Show member pathways
 12.8 CXCL8 IL1B IL6 TLR4 TNF
14
NF-KappaB Family Pathway 64
Show member pathways
 12.76 FLT1 IL1A IL1B IL1R1 IL6 TLR4
15
Regulation of IFNA signaling 66
Show member pathways
 12.7 CXCL8 IL1A IL1B IL6 TNF
16
4-1BB Pathway 64
Show member pathways
 12.66 IL1A IL1B IL1R1 TNF
17
Kaposi's sarcoma-associated herpesvirus infection 37
Show member pathways
 12.63 CXCL8 IL6 MMP9 TLR4 TNF
18
TRAF Pathway 64
Show member pathways
 12.6 IL1A IL1B IL1R1 TLR4 TNF
19
Immune response IL-23 signaling pathway 22
Show member pathways
 12.59 CCL2 IL1B IL6 TNF
20
Th17 cell differentiation 37
Show member pathways
 12.54 IL1A IL1B IL1R1 IL6 TLR4 TNF
21
Apoptosis Pathway 72
Show member pathways
 12.47 FLT1 IL1A IL1B IL1R1
22
T cell receptor signaling pathway 37
Show member pathways
 12.46 IL1A IL1B IL6 TNF
23
Folate Metabolism 1
Show member pathways
 12.42 CCL2 CRP IL1B IL6 TNF
24
IL-17 Family Signaling Pathways 65
Show member pathways
 12.41 CCL2 CXCL8 IL1B IL6 MMP9 TNF
25
Diseases associated with the TLR signaling cascade 66
Show member pathways
 12.36 CXCL8 IL1A IL6 TLR4 TNF
26
IL-1 signaling pathway 1
Show member pathways
 12.35 CCL2 IL1A IL1B IL1R1
27
Th1 Differentiation Pathway 65
Show member pathways
 12.35 IL1B IL1R1 IL6 TLR4 TNF
28
Transcriptional misregulation in cancer 37
12.35 CXCL8 ELANE FLT1 IL6 MMP9
29
Tuberculosis 37
12.33 IL1A IL1B IL6 TLR4 TNF
30
Toxoplasmosis 37
Show member pathways
 12.31 IL1A IL1B TLR4 TNF
31
IL-1 Family Signaling Pathways 65
Show member pathways
 12.29 CXCL8 IL1A IL1B IL1R1 IL6 TNF
32
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.28 CXCL8 IL1A IL1B IL6 TNF
33
Necroptosis 37
Show member pathways
 12.27 IL1A IL1B TLR4 TNF
34
Toll Comparative Pathway 64
Show member pathways
 12.27 CXCL8 IL1A IL1B IL1R1 IL6 TLR4
35
Colorectal Cancer Metastasis 64
12.25 IL6 MMP9 TLR4 TNF
36
Bacterial infections in CF airways 22
Show member pathways
 12.24 CXCL8 IL1B IL1R1 IL6 TLR4 TNF
37
Fluid shear stress and atherosclerosis 37
12.14 CCL2 IL1A IL1B IL1R1 MMP9 TNF
38
Immune response IFN gamma signaling pathway 22
Show member pathways
 12.13 CCL2 CXCL8 FLT1 IL1A IL1B IL1R1
39
Osteoclast differentiation 37
12.12 IL1A IL1B IL1R1 TNF
40
MAPK Pathway 72
Show member pathways
 12.1 IL1A IL1B IL1R1 TLR4
41
TNF signaling pathway 37
12.06 CCL2 IL1B IL6 MMP9 TNF
42
Senescence and Autophagy in Cancer 1
12.03 CXCL8 IL1A IL1B IL6
43
Hematopoietic cell lineage 37
12 IL1A IL1B IL1R1 IL6 TNF
44
Matrix Metalloproteinases 1
Show member pathways
 11.99 ELANE MMP8 MMP9 TNF
45
NF-kappa B signaling pathway 37
11.99 CXCL8 IL1B IL1R1 TLR4 TNF
46
AGE-RAGE signaling pathway in diabetic complications 37
11.98 CCL2 CXCL8 IL1A IL1B IL6 TNF
47
Amoebiasis 37
11.94 CXCL8 IL1B IL1R1 IL6 TLR4 TNF
48
HIF-1 signaling pathway 37
11.93 FLT1 IL6 TLR4
49
Salmonella infection (KEGG) 37
11.92 CXCL8 IL1A IL1B IL6 TLR4
50
Cytokine production by Th17 cells in CF (Mouse model) 22
Show member pathways
 11.9 CXCL8 IL6 TLR4
Sources

GO Terms for Chorioamnionitis

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Cellular components related to Chorioamnionitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.73 CCL2 CRP CXCL8 ELANE FLT1 IL1A
2 extracellular region GO:0005576 9.44 CCL2 CRP CXCL8 ELANE FLT1 IL1A
3 secretory granule GO:0030141 9.33 ELANE IL1B OXT

Biological processes related to Chorioamnionitis according to GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Name GO ID Score Top Affiliating Genes
1 leukocyte migration GO:0050900 9.96 ELANE IL1B MMP9 TNF
2 positive regulation of gene expression GO:0010628 9.95 CRP IL1A IL1B IL6 TLR4 TNF
3 response to lipopolysaccharide GO:0032496 9.93 CXCL8 ELANE IL1B TLR4
4 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.91 IL1A IL1B TLR4 TNF
5 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.91 CCL2 FLT1 IL1A TLR4 TNF
6 activation of MAPK activity GO:0000187 9.89 IL1B TLR4 TNF
7 positive regulation of DNA binding transcription factor activity GO:0051091 9.89 IL1B IL6 TNF
8 defense response to Gram-positive bacterium GO:0050830 9.88 CRP IL6 TNF
9 interleukin-1-mediated signaling pathway GO:0070498 9.87 IL1A IL1B IL1R1
10 regulation of inflammatory response GO:0050727 9.87 IL1R1 TLR4 TNF
11 positive regulation of angiogenesis GO:0045766 9.87 CXCL8 FLT1 IL1A IL1B
12 regulation of signaling receptor activity GO:0010469 9.87 CCL2 CXCL8 IL1A IL1B IL6 OXT
13 extracellular matrix disassembly GO:0022617 9.86 ELANE MMP8 MMP9
14 cellular response to organic cyclic compound GO:0071407 9.86 CCL2 IL1B TNF
15 immune response GO:0006955 9.86 CCL2 CXCL8 IL1A IL1B IL1R1 IL6
16 neutrophil chemotaxis GO:0030593 9.85 CCL2 CXCL8 IL1B
17 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.85 IL1B IL6 TLR4 TNF
18 response to glucocorticoid GO:0051384 9.84 IL6 OXT TNF
19 positive regulation of MAP kinase activity GO:0043406 9.84 ELANE FLT1 TNF
20 humoral immune response GO:0006959 9.83 CCL2 IL6 TNF
21 positive regulation of smooth muscle cell proliferation GO:0048661 9.83 ELANE IL6 TNF
22 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.8 IL1B TLR4 TNF
23 positive regulation of JNK cascade GO:0046330 9.8 IL1A IL1B TLR4 TNF
24 cellular response to lipopolysaccharide GO:0071222 9.8 CCL2 CXCL8 IL6 TLR4 TNF
25 protein kinase B signaling GO:0043491 9.79 CCL2 IL1B TNF
26 monocyte chemotaxis GO:0002548 9.78 CCL2 FLT1 IL6
27 positive regulation of interferon-gamma production GO:0032729 9.77 IL1B TLR4 TNF
28 positive regulation of nitric oxide biosynthetic process GO:0045429 9.77 IL1B TLR4 TNF
29 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.73 IL1A IL1B TNF
30 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.72 FLT1 IL1B
31 embryonic digestive tract development GO:0048566 9.72 CXCL8 TNF
32 negative regulation of lipid catabolic process GO:0050995 9.72 IL1B TNF
33 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.71 IL1B TNF
34 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.71 CCL2 TLR4
35 negative regulation of growth of symbiont in host GO:0044130 9.71 ELANE TNF
36 positive regulation of interleukin-8 production GO:0032757 9.71 IL1B TLR4 TNF
37 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.7 IL1A IL1B
38 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.7 IL1B TNF
39 positive regulation of monocyte chemotactic protein-1 production GO:0071639 9.7 IL1A IL1B
40 PERK-mediated unfolded protein response GO:0036499 9.7 CCL2 CXCL8
41 positive regulation of chemokine production GO:0032722 9.7 IL6 TLR4 TNF
42 positive regulation of chemokine biosynthetic process GO:0045080 9.68 IL1B TNF
43 ectopic germ cell programmed cell death GO:0035234 9.68 IL1A IL1B
44 regulation of establishment of endothelial barrier GO:1903140 9.68 IL1B TNF
45 positive regulation of prostaglandin secretion GO:0032308 9.67 IL1B OXT
46 lipopolysaccharide-mediated signaling pathway GO:0031663 9.67 CCL2 IL1B TLR4 TNF
47 positive regulation of fever generation GO:0031622 9.65 IL1B TNF
48 fever generation GO:0001660 9.64 IL1A IL1B
49 positive regulation of neutrophil extravasation GO:2000391 9.64 IL1A IL1R1
50 negative regulation of lipid storage GO:0010888 9.63 CRP IL6 TNF

Molecular functions related to Chorioamnionitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 interleukin-1 receptor binding GO:0005149 9.16 IL1A IL1B
2 protease binding GO:0002020 9.13 ELANE IL1R1 TNF
3 cytokine activity GO:0005125 9.1 CCL2 CXCL8 IL1A IL1B IL6 TNF
Sources

Sources for Chorioamnionitis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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