Chorioamnionitis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: CHR005 MIFTS: 54	Chorioamnionitis Categories: Fetal diseases
Genes Tissues Related diseases Publications Pathways Drugs Expand all tables

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Aliases & Classifications for Chorioamnionitis

MalaCards integrated aliases for Chorioamnionitis:

Name: Chorioamnionitis ¹² ⁵⁵ ⁴⁴ ¹⁵ ⁷³

Classifications:

MalaCards categories:
Global: Fetal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0050697

MeSH ⁴⁴ D002821

UMLS ⁷³ C0008495

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Summaries for Chorioamnionitis

Disease Ontology : ¹² A placenta disease that is an inflammation of the fetal membranes (amnion and chorion) due to a bacterial infection.

MalaCards based summary : Chorioamnionitis is related to funisitis and preterm premature rupture of the membranes. An important gene associated with Chorioamnionitis is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Cefuroxime and Ampicillin have been mentioned in the context of this disorder. Affiliated tissues include placenta, lung and brain, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : ⁷⁶ Chorioamnionitis also known as intra-amniotic infection (IAI) is an inflammation of the fetal membranes... more...

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Related Diseases for Chorioamnionitis

Diseases related to Chorioamnionitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 373)

#	Related Disease	Score	Top Affiliating Genes
1	funisitis	31.0	CXCL8 IL1B IL6 MMP8
2	preterm premature rupture of the membranes	30.7	CRP CXCL8 IL1B IL6 MMP8 MMP9
3	cerebral palsy	30.5	IL1B IL6 MMP8 TNF
4	endometritis	30.3	IL1B IL6 OXT TNF
5	bronchopulmonary dysplasia	30.2	CXCL8 ELANE FLT1 IL1RN
6	haemophilus influenzae	30.2	CXCL8 IL1B TNF
7	vasculitis	30.1	CCL2 CRP ELANE TNF
8	eclampsia	30.0	FLT1 OXT TNF
9	bacterial vaginosis	29.9	CXCL8 IL1A IL1B IL6 TLR4 TNF
10	septic arthritis	29.8	CRP CXCL8 TLR4
11	adult respiratory distress syndrome	29.7	CXCL8 ELANE IL6 TNF
12	newborn respiratory distress syndrome	29.7	CXCL8 ELANE IL1B IL6
13	bacteriuria	29.6	CCL2 CXCL8 IL6 TLR4
14	perinatal necrotizing enterocolitis	29.6	CRP CXCL8 IL1B IL6 TLR4 TNF
15	lung disease	29.6	CCL2 CXCL8 ELANE IL1B IL6 MMP8
16	pre-eclampsia	29.6	FLT1 IL6 OXT TLR4 TNF
17	toxic shock syndrome	29.6	CXCL8 IL1B IL6 TLR4 TNF
18	otitis media	29.6	CXCL8 IL1B IL6 TLR4 TNF
19	appendicitis	29.5	CRP CXCL8 IL1B IL6 MMP8 MMP9
20	pertussis	29.5	IL1A IL1B IL6 TLR4 TNF
21	endometriosis	29.5	CCL2 CXCL8 IL1B IL6
22	respiratory failure	29.5	CRP CXCL8 ELANE TNF
23	chlamydia	29.2	CRP CXCL8 IL1A IL1B IL6 TLR4
24	pneumonia	29.2	CCL2 CRP CXCL8 ELANE IL1B IL6
25	arthritis	29.0	CCL2 CXCL8 IL1A IL1B IL1RN IL6
26	malaria	28.5	CCL2 CRP CXCL8 IL1A IL1B IL1RN
27	asthma	28.1	CCL2 CXCL8 ELANE IL1A IL1B IL1R1
28	listeriosis	11.4
29	retinitis pigmentosa 55	10.3	IL6 TNF
30	angioimmunoblastic lymphadenopathy with dysproteinemia	10.3	IL6 TNF
31	critical limb ischemia	10.3	IL6 TNF
32	papillary conjunctivitis	10.3	CXCL8 IL6
33	brain injury	10.3
34	tungiasis	10.3	CXCL8 TNF
35	null-cell leukemia	10.3	IL6 TNF
36	anca-associated vasculitis	10.3	IL6 TNF
37	leukomalacia	10.3	IL6 TNF
38	scorpion envenomation	10.3	IL6 TNF
39	cardiogenic shock	10.3	IL6 TNF
40	peptic esophagitis	10.3	CXCL8 IL1B
41	kashin-beck disease	10.3	IL1B TNF
42	paraneoplastic syndromes	10.3	IL1B IL6
43	leukoregulin	10.3	CXCL8 IL1A
44	rheumatoid lung disease	10.3	IL1B TNF
45	staphylococcal toxic shock syndrome	10.3	IL1B TNF
46	skin conditions	10.3	IL1A TNF
47	myasthenic syndrome, congenital, 1a, slow-channel	10.3	CRP CXCL8
48	scabies	10.3	CXCL8 IL1A
49	pyuria	10.3	CRP CXCL8
50	cold agglutinin disease	10.3	CRP IL6

Graphical network of the top 20 diseases related to Chorioamnionitis:

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Symptoms & Phenotypes for Chorioamnionitis

MGI Mouse Phenotypes related to Chorioamnionitis:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cardiovascular system	MP:0005385	10.11	CRP FLT1 IL1A IL1B IL1R1 IL1RN
2	homeostasis/metabolism	MP:0005376	10.07	CRP ELANE FLT1 IL1A IL1B IL1R1
3	hematopoietic system	MP:0005397	10.02	ELANE FLT1 IL1A IL1B IL1R1 IL1RN
4	immune system	MP:0005387	9.97	CCL2 CRP ELANE FLT1 IL1A IL1B
5	integument	MP:0010771	9.61	IL1A IL1B IL1R1 IL1RN IL6 MMP9
6	neoplasm	MP:0002006	9.28	ELANE IL1A IL1B IL1R1 IL6 MMP8

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Drugs & Therapeutics for Chorioamnionitis

Drugs for Chorioamnionitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 182)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Cefuroxime

Approved

Phase 4

55268-75-2

5361202 5479529

Ampicillin

Approved, Vet_approved

Phase 4,Phase 2,Phase 3,Not Applicable

69-53-4

6249

Dinoprostone

Approved

Phase 4,Phase 3,Not Applicable

363-24-6

5280360

Clindamycin

Approved, Vet_approved

Phase 4,Not Applicable

18323-44-9

29029

Misoprostol

Approved

Phase 4,Phase 2,Not Applicable

59122-46-2

5282381

Oxytocin

Approved, Vet_approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

50-56-6

439302 53477758

Progesterone

Approved, Vet_approved

Phase 4,Phase 3,Phase 2,Not Applicable

57-83-0

5994

Azithromycin

Approved

Phase 4

83905-01-5

55185 447043

Amoxicillin

Approved, Vet_approved

Phase 4

26787-78-0

33613

Povidone-iodine

Approved

Phase 4,Not Applicable

25655-41-8

Alprostadil

Approved, Investigational

Phase 4

745-65-3

149351 5280723

Glucosamine

Approved, Investigational

Phase 4

3416-24-8

439213

Antibiotics, Antitubercular

Phase 4,Phase 3,Phase 2,Not Applicable

cefuroxime axetil

Phase 4

Anti-Bacterial Agents

Phase 4,Phase 2,Phase 3,Not Applicable

Antitubercular Agents

Phase 4,Phase 2,Phase 3,Not Applicable

Anti-Infective Agents

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

Oxytocics

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Clindamycin palmitate

Phase 4,Not Applicable

Clindamycin phosphate

Phase 4,Not Applicable

Antacids

Phase 4,Phase 2,Not Applicable

Anti-Ulcer Agents

Phase 4,Phase 2,Not Applicable

Gastrointestinal Agents

Phase 4,Phase 3,Phase 2,Not Applicable

Peripheral Nervous System Agents

Phase 4,Phase 3,Phase 2,Not Applicable

Anesthetics

Phase 4,Phase 3,Not Applicable

Analgesics

Phase 4,Phase 3,Phase 2,Not Applicable

Gentamicins

Phase 4,Phase 2,Phase 3,Not Applicable

Mydriatics

Phase 4

Adjuvants, Anesthesia

Phase 4

Parasympatholytics

Phase 4

Scopolamine hydrobromide

Phase 4

114-49-8

Cholinergic Agents

Phase 4

Muscarinic Antagonists

Phase 4

Cholinergic Antagonists

Phase 4

Neurotransmitter Agents

Phase 4

Butylscopolammonium Bromide

Phase 4

Anticonvulsants

Phase 4,Phase 3

Autonomic Agents

Phase 4,Phase 2,Phase 3

Bromides

Phase 4

Immunologic Factors

Phase 4,Phase 2

Vaccines

Phase 4,Phase 2,Not Applicable

Progestins

Phase 4,Phase 3,Phase 2,Not Applicable

Hormones

Phase 4,Phase 3,Phase 2,Not Applicable

Hormone Antagonists

Phase 4,Phase 3,Phase 2,Not Applicable

Hormones, Hormone Substitutes, and Hormone Antagonists

Phase 4,Phase 3,Phase 2,Not Applicable

Pharmaceutical Solutions

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

Laxatives

Phase 4

Carboxymethylcellulose Sodium

Phase 4

Cathartics

Phase 4

Glucuronyl glucosamine glycan sulfate

Phase 4

Interventional clinical trials:

(show top 50) (show all 183)

#	Name	Status	NCT ID	Phase	Drugs
1	Comparison of Two Antibiotic Prophylactic Protocols in Preterm Premature Rupture of the Membranes	Unknown status	NCT02819570	Phase 4	I.V cefuroxime 750 mg3/d for 2 days;I.V ampicillin 2 gram x4/d for 2 days;P.O cefuroxime 500 mgx2/d for 5 days;P.O roxithromycin 150 mg2/d for 7 days;P.O moxypen 500 mgx3/d for 5 days
2	A Trial of Prostaglandin E2 Tablets Versus Foley Catheter for Labor Induction	Unknown status	NCT02486679	Phase 4	Prostin (PGE2) tablets
3	Prevention of Very Preterm Delivery by Testing for and Treatment of Bacterial Vaginosis	Completed	NCT00642980	Phase 4	Clindamycin;Placebo;Clindamycin
4	Randomized Trial Comparing Misoprostol and Foley Bulb for Pregnancy Termination in the Second Trimester	Completed	NCT00324519	Phase 4	misoprostol
5	Safety Study of Hyoscine N Butyl Bromide in Active Management of Labor	Completed	NCT02098889	Phase 4	hyoscine-N-butyl bromide(HBB);Saline
6	Oxytocin Regimen to Prevent Atony and Postpartum Hemorrhage During Vaginal Delivery: 3-arm RCT	Completed	NCT00790062	Phase 4	Oxytocin
7	A Trial of Oral Misoprostol for Labor Augmentation	Completed	NCT00906347	Phase 4	Misoprostol;Oxytocin
8	Safety and Immunogenicity of Simultaneous Tdap and IIV in Pregnant Women	Completed	NCT02783170	Phase 4
9	Prevention of Preterm Birth in Pregnant Women at Risk Identified by Ultrasound: Evaluation of Two Treatment Strategies	Completed	NCT01643980	Phase 4	Vaginal micronized progesterone
10	Induction of Labor With a Foley Balloon Catheter: Inflation With 30ml Compared to 60ml	Completed	NCT00451308	Phase 4
11	Antibiotic Prophlaxis for High-risk Laboring Women in Low Income Countries	Recruiting	NCT03248297	Phase 4	Azithromycin;Azithromycin and amoxicillin;Placebo
12	Cervical Cerclage for Preventing Spontaneous Preterm Birth in Singleton Pregnancies Without Prior Spontaneous Preterm Birth and With Short Transvaginal Ultrasound Cervical Length	Recruiting	NCT02746900	Phase 4
13	Comparison of Low-dose and High-dose Oxytocin Regimens for Labor Augmentation	Recruiting	NCT02487797	Phase 4	Oxytocin
14	Cervical Ripening for Obese Women: A Randomized, Comparative Effectiveness Trial	Recruiting	NCT02639429	Phase 4	Vaginal Misoprostol
15	Foley Bulb With Oral Misoprostol for Induction of Labor	Recruiting	NCT03407625	Phase 4
16	A Comparison of Oral Misoprostol and Vaginal Misoprostol for Cervical Ripening and Induction of Labor	Recruiting	NCT02777190	Phase 4	Misoprostol
17	Vaginal Progesterone for the Prolongation of Pregnancy After Arrested Pre-term Labor	Recruiting	NCT02430233	Phase 4	micronized progesterone 400 mg (Utrogestan)
18	Comparison of Misoprostol Ripening Efficacy With Dilapan	Recruiting	NCT03670836	Phase 4	Misoprostol
19	Cook Balloon Versus Propess After 12 Hours of Rupture of Membranes	Recruiting	NCT03310333	Phase 4	Propess® (dinoprostone)
20	The Obese Pitocin Study	Recruiting	NCT03140488	Phase 4	Oxytocin
21	TRAP Intervention STudy: Early Versus Late Intervention for Twin Reversed Arterial Perfusion Sequence	Recruiting	NCT02621645	Phase 4
22	Treatment Utility of Postpartum Antibiotics in Chorioamnionitis	Terminated	NCT01585129	Phase 4	Postpartum Antibiotics;No postpartum antibiotics
23	Removal Versus Retention of Cerclage in Preterm Premature Rupture of Membranes (PPROM)	Terminated	NCT00201656	Phase 4
24	Buccal Versus Vaginal Misoprostol for Third Trimester Induction of Labor	Terminated	NCT01519765	Phase 4	Buccal Misoprostol;Vaginal misoprostol
25	Intrapartum Fever: Antibiotics Versus no Treatment	Withdrawn	NCT03168178	Phase 4	Standard Antibiotic Treatment
26	Bacterial Vaginosis Screening and Treatment to Reduce Infective Complications, Abortion and Preterm Delivery	Unknown status	NCT00491270	Phase 3
27	Trial of AMNIOECHANGE in Gastroschisis Affected Foetuses	Unknown status	NCT00127946	Phase 3
28	Pessary as Adjunctive Therapy to Cerclage for the Prevention of Preterm Birth	Unknown status	NCT02678026	Phase 3
29	Ampicillin / Sulbactam vs. Ampicillin / Gentamicin for Treatment of Chorioamnionitis	Completed	NCT00879190	Phase 2, Phase 3	Unasyn;Ampicillin/gentamicin
30	Antibiotics to Reduce Chorioamnionitis-Related Perinatal HIV Transmission	Completed	NCT00021671	Phase 3	Erythromycin;Nevirapine;Ampicillin sodium;Metronidazole
31	Antibiotic Prophylaxis in Prelabor Rupture of Membranes at Term	Completed	NCT01633294	Phase 2, Phase 3	Ampicillin + gentamicin
32	Antibiotics Study in Preterm Premature Rupture of the Membranes	Completed	NCT01401179	Phase 3	cefazolin, erythromycin, clarithromycin
33	Combined Anesthesia for Labor and Maternal Temperature	Completed	NCT01078519	Phase 3	Combined epidural and spinal anesthesia
34	Induction of Labor in Term Premature Rupture of Membranes: A Comparison Between Oxytocin and Dinoprostone Followed Six Hours Later by Oxytocin	Completed	NCT01099280	Phase 3	SYNPITAN FORT 5 IU;Propess,SYNPITAN FORT
35	Chlorhexidine Vaginal and Infant Wash in Pakistan	Completed	NCT00121394	Phase 3
36	Does Vitamins C and E Supplementation of After Preterm Rupture of Membranes Prolong the Duration of Latency? A Prospective Randomized Controlled Study	Completed	NCT01266928	Phase 3	vitamine C and E
37	Pessary in Singleton Gestations With Short Cervix Without Prior Preterm Birth	Completed	NCT02716909	Phase 3
38	Fetal ST Segment and T Wave Analysis in Labor	Completed	NCT01131260	Phase 3
39	Beneficial Effects of Antenatal Magnesium Sulfate (BEAM Trial)	Completed	NCT00014989	Phase 3	magnesium sulfate
40	Trial of Progesterone in Twins and Triplets to Prevent Preterm Birth (STTARS)	Completed	NCT00099164	Phase 3	17 alpha-hydroxyprogesterone caproate (17P)
41	Reduction of Spontaneous Prematurity by Antibiotic Treatment (Josamycin)	Completed	NCT00718705	Phase 3	Josamycin;Placebo
42	Cerclage for Singletons With Short Cervix Without Prior Preterm Birth	Recruiting	NCT02716922	Phase 3
43	Effects of ACS in Twin With LPB: Study Protocol for a RCT	Recruiting	NCT03547791	Phase 2, Phase 3	Betamethason Sodium Phosphate;Normal saline
44	Does a Rescue Course of Betamethasone in Pregnant Women With PPROM Decrease Neonatal Morbidity?	Recruiting	NCT02939742	Phase 2, Phase 3	Betamethasone;Placebo
45	Comparison of Insulin Alone to Insulin With Metformin to Treat Gestational Diabetes Mellitus	Recruiting	NCT03651531	Phase 3	Insulin;Metformin
46	Impact of a Booster Course of Antenatal Steroids on Neonatal Outcome in Patients With Premature Rupture of the Membranes	Recruiting	NCT02469519	Phase 2, Phase 3	Betamethasone - ACTIVE
47	Antenatal Late Preterm Steroids (ALPS): A Randomized Placebo-Controlled Trial	Active, not recruiting	NCT01222247	Phase 3	Betamethasone;Placebo
48	Oral Probiotic Supplementation in Pregnancy to Reduce Group B Streptococcus Colonization	Not yet recruiting	NCT03407157	Phase 3
49	Progesterone for Maintenance Tocolysis: A Randomized Placebo Controlled Trial	Terminated	NCT00946088	Phase 2, Phase 3	Progesterone;Polyethylene glycol&hydrogenated vegetable oil.
50	A Phase III Efficacy and Safety Study of Intravenous Retosiban Versus Placebo for Women in Spontaneous Preterm Labor	Terminated	NCT02377466	Phase 3	Retosiban IV infusion;Placebo IV infusion

Search NIH Clinical Center for Chorioamnionitis

Cochrane evidence based reviews: chorioamnionitis

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Genetic Tests for Chorioamnionitis

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Anatomical Context for Chorioamnionitis

MalaCards organs/tissues related to Chorioamnionitis:

⁴¹

Placenta, Lung, Brain, Uterus, Skin, Neutrophil, Heart

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Publications for Chorioamnionitis

Articles related to Chorioamnionitis:

(show top 50) (show all 924)

#	Title	Authors	Year
1	Association of Histologic Chorioamnionitis With Perinatal Brain Injury and Early Childhood Neurodevelopmental Outcomes Among Preterm Neonates. ( 29610829 )	Bierstone D....Miller S.P.	2018
2	Incidence of early-onset sepsis in infants born to women with clinical chorioamnionitis. ( 29791315 )	Randis T.M....Sorokin Y.	2018
3	The expression of Toll-like receptor 5 in preterm histologic chorioamnionitis. ( 29371755 )	Moroi H....Kikkawa F.	2018
4	Histologic chorioamnionitis in preterm infants: correlation with brain magnetic resonance imaging at term equivalent age. ( 29448926 )	Granger C....Cheong J.	2018
5	Impact of histologic chorioamnionitis on pulmonary hypertension and respiratory outcomes in preterm infants. ( 29480140 )	Yum S.K....Sung I.K.	2018
6	Chorioamnionitis exposure dampens the preterm monocyte response to subsequent challenges. ( 29931696 )	Bermick J....Schaller M.	2018
7	Suspected Chorioamnionitis and Myometrial Contractility: Mechanisms for Increased Risk of Cesarean Delivery and Postpartum Hemorrhage. ( 29848185 )	Zackler A....Goetzl L.	2018
8	Persistent Pulmonary Hypertension and Histologic Chorioamnionitis in Preterm Infants: Controlled Study. ( 29453682 )	Katz N....Kohelet D.	2018
9	Prediction of histological chorioamnionitis and neonatal and infantile outcomes using procalcitonin in the umbilical cord blood and amniotic fluid at birth. ( 29315994 )	Horinouchi T....Ushijima K.	2018
10	Case Report: Chorioamnionitis and Premature Delivery due to<i>Burkholderia pseudomallei</i>Infection in Pregnancy. ( 29363450 )	Porter M.C....Currie B.J.	2018
11	Intrapartum Management of Chorioamnionitis. ( 29215424 )	Wisner K.	2018
12	Daily gentamicin using ideal body weight demonstrates lower risk of postpartum endometritis and increased chance of successful outcome compared with traditional 8-hour dosing for the treatment of intrapartum chorioamnionitis. ( 29642754 )	Martingano D....Carey J.	2018
13	Concurrent intraoperative uterine rupture and placenta accreta. Do preoperative chronic hypertension, preterm premature rupture of membranes, chorioamnionitis, and placental abruption provide warning to this rare occurrence? ( 29756067 )	Cometa M.A....Wendling A.L.	2018
14	Chorioamnionitis, neuroinflammation, and injury: timing is key in the preterm ovine fetus. ( 29673373 )	Gussenhoven R....Wolfs T.G.A.M.	2018
15	Exposure to chorioamnionitis alters the monocyte transcriptional response to the neonatal pathogen Staphylococcus epidermidis. ( 29533486 )	de Jong E....Currie A.J.	2018
16	The Consequences of Preterm Birth and Chorioamnionitis on Brainstem Respiratory Centers: Implications for Neurochemical Development and Altered Functions by Inflammation and Prostaglandins. ( 29449803 )	Stojanovska V....Polglase G.R.	2018
17	Chorioamnionitis Induces a Specific Signature of Placental ABC Transporters Associated with an Increase of miR-331-5p in the Human Preterm Placenta. ( 29402780 )	do Imperio G.E....Matthews S.G.	2018
18	Validation of diagnostic tests for histologic chorioamnionitis: Systematic review and meta-analysis. ( 29908373 )	CataA+o Sabogal C.P....GarcA-a-Perdomo H.A.	2018
19	The change of fetal heart rate short-term variability during the course of histological chorioamnionitis in fetal sheep. ( 29908375 )		2018
20	Clinical Monitoring of Well-Appearing Infants Born to Mothers With Chorioamnionitis. ( 29599112 )		2018
21	Subclinical and clinical chorioamnionitis, fetal vasculitis, and risk for preterm birth: A cohort study. ( 29941174 )		2018
22	In response: Is early onset sepsis risk calculator safe for the management of neonates born to mothers with chorioamnionitis? ( 29795323 )		2018
23	Case report of Staphylococcus epidermidis maternal sepsis and chorioamnionitis following fetoscopy. ( 29055131 )		2018
24	Increased miR-223 expression in foetal organs is a signature of acute chorioamnionitis with systemic consequences. ( 29083107 )		2018
25	Does maternal chorioamnionitis have to equal antibiotics in an asymptomatic infant? ( 29887607 )		2018
26	Discharge breastmilk feeding rates in asymptomatic term newborns admitted to the neonatal intensive care unit for maternal chorioamnionitis. ( 29526120 )		2018
27	Maternal Serum Interleukin-6: A Non-Invasive Predictor of Histological Chorioamnionitis in Women with Preterm-Prelabor Rupture of Membranes. ( 29635237 )		2018
28	Antenatal Vitamin D Preserves Placental Vascular and Fetal Growth in Experimental Chorioamnionitis Due to Intra-amniotic Endotoxin Exposure. ( 29715698 )		2018
29	Daily dosing of gentamicin using ideal body weight for the treatment of intrapartum chorioamnionitis: a pilot study. ( 28349720 )	Martingano D...Carey J	2018
30	Magnesium sulfate for neuroprotection in the setting of chorioamnionitis. ( 28395549 )	Edwards JM...Grotegut CA	2018
31	Prediction of chorioamnionitis in cases of intraamniotic infection by ureaplasma urealyticum in women with very preterm premature rupture of membranes or preterm labour. ( 28502201 )	Revello R...Bartha JL	2018
32	Maternal Glucose Supplementation in a Murine Model of Chorioamnionitis Alleviates Dysregulation of Autophagy in Fetal Brain. ( 29017418 )	Lei J...Burd I	2018
33	Is early-onset sepsis risk calculator safe for the management of neonates born to mothers with chorioamnionitis? ( 29467522 )	Aghai ZH	2018
34	"Capnocytophaga spp. infection causing chorioamnionitis: an unusual suspect". ( 30031140 )	Felix L...Hamula C	2018
35	Association between clinical chorioamnionitis and histological funisitis at term. ( 30040750 )	Suzuki S	2018
36	Infants Born to Mothers with Clinical Chorioamnionitis: A Cross-Sectional Survey on the Use of Early-Onset Sepsis Risk Calculator and Prolonged Use of Antibiotics. ( 30130819 )	Ayrapetyan M...Aghai ZH	2018
37	Implementation of the sepsis risk score for chorioamnionitis-exposed newborns. ( 30158677 )	Gievers LL...Khaki S	2018
38	Lipopolysaccharide-induced chorioamnionitis and postnatal lung injury: The beneficial effects of L-citrulline in newborn rats. ( 30198795 )	Dedja A...Zaramella P	2018
39	Applying the neonatal Early-Onset Sepsis calculator in cases of clinical chorioamnionitis at or after 34 weeks of gestation. ( 30201182 )	Degraeuwe P	2018
40	Immunohistochemical demonstration of RECK protein and interleukin-6 in fetal membranes from singleton pregnancies with late preterm delivery, intact membranes and histological chorioamnionitis. ( 30230382 )	Benzon Z...Stefanovic V	2018
41	Vaginal Ureaplasma species increase chorioamnionitis in very preterm infants with preterm premature rupture of the membranes at < 28 weeks of gestation. ( 30244363 )	Suzuki Y...Ohkuchi A	2018
42	Chorioamnionitis Is a Risk Factor for Intraventricular Hemorrhage in Preterm Infants: A Systematic Review and Meta-Analysis. ( 30271352 )	Villamor-Martinez E...Villamor E	2018
43	Clinical Chorioamnionitis at Term: New Insights into the Etiology, Microbiology, and the Fetal, Maternal and Amniotic Cavity Inflammatory Responses. ( 30320312 )	Romero R...Yoon BH	2018
44	Chorioamnionitis as a risk factor for retinopathy of prematurity: An updated systematic review and meta-analysis. ( 30332485 )	Villamor-Martinez E...Villamor E	2018
45	DNA methylation profiling of acute chorioamnionitis-associated placentas and fetal membranes: insights into epigenetic variation in spontaneous preterm births. ( 30373633 )	Konwar C...Robinson WP	2018
46	Clinical chorioamnionitis at term IX: in vivo evidence of intra-amniotic inflammasome activation. ( 30412466 )	Gomez-Lopez N...Hsu CD	2018
47	Fetal cord blood and tissue immune responses to chronic placental inflammation and chorioamnionitis. ( 30473713 )	Singh AM...Kumar R	2018
48	Challenging management of chorioamnionitis with placental listeriosis: lessons from 2 cases. ( 30474016 )	Park JH...Kim YH	2018
49	Association of chorioamnionitis and its duration with adverse maternal outcomes by mode of delivery: a cohort study. ( 30485648 )	Venkatesh KK...Stamilio DM	2018
50	Histological chorioamnionitis and developmental outcomes in very preterm infants. ( 30518803 )	Strunk T...Doherty D	2018

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Genes for Chorioamnionitis

Genes related to Chorioamnionitis (0 elite genes):

(show all 15)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	TNF	Tumor Necrosis Factor	Protein Coding	34.76	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	17273989 11006206 19292050 (more) 10224608 19669033 10806666 10749467 9595363 17003486 10923535 10426263 10820910 11082954 8497360 11304864 14671209 17940116 16199639 16376986 12850624 9396923 15983435 18645461 16814164 14968205 15507966 11883229 9822511 17194482 10924750 1595815 19164476 19272692 9127126 8492010 17145371 10599732 15128916 9373840
2	IL6	Interleukin 6	Protein Coding	33.59	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	11979375 8725257 11006206 (more) 12092128 10338061 9654173 10749467 12380603 12235716 9194619 10806666 15983435 8178864 18571528 10224608 9595363 18476141 11883229 8420357 10924750 11263180 11861935 17000235 16389028 20171025 11125929 10820910 10874989 19842878 8497360 18971361 18395034 16459014 9396923 9277663 8629898 19668329 18475321 17594943 17437242 16549908 16338780 9822511 8311926 8838971 9065108 7892891 18192328 16988192 16199639 11916177 10426263 9185076 15611353 7943078 8509668 15893869 15547537 10080881 9890219 19318420 11120524 10195738 8885727 19272692 18358131 15183137 17405871
3	CXCL8	C-X-C Motif Chemokine Ligand 8	Protein Coding	32.23	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	8429521 8238198 10456863 (more) 1569349 9184952 20038922 9494917 9744050 17003486 12235716 15983435 1391327 10924750 11883229 10923535 10820910 9595363 9536833 8838971 1522134 18192328 12359779 9757992 9396923 18475321 17594943 7738906 17405871 10460229 16549908 15611353 19272692 8089606
4	IL1B	Interleukin 1 Beta	Protein Coding	30.7	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	8178864 8497360 9536833 (more) 12569180 19272692 10599732 15611353 17594943 11861935 8838971 19164476 17940116 17003486 16199639 11839503 15998775 18475321 17437242 8584379 10080881 11125929 14671209 8509668
5	CRP	C-Reactive Protein	Protein Coding	30.5	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	17567416 19819609 2353964 (more) 10775727 11008336 17426373 16108395 9813940 17437242 18938289 9194619 16126504 16390808 8331777 15025328 15315168 18358131 18783308 11495410 14669391
6	MMP8	Matrix Metallopeptidase 8	Protein Coding	30	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	14711859
7	ELANE	Elastase, Neutrophil Expressed	Protein Coding	26.05	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	17364282 19323055 16752257 (more) 8462835 8230740
8	TLR4	Toll Like Receptor 4	Protein Coding	25.48	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	16157088 14745724 16814164 (more) 17064297 18345485 17055575
9	IL1R1	Interleukin 1 Receptor Type 1	Protein Coding	23.77	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	7506905 8885727 8838971
10	OXT	Oxytocin/Neurophysin I Prepropeptide	Protein Coding	23.69	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	1579312 9170488 10796160 (more) 10796161 8238153 15229013 19821304 9207828 16750257 17636608 7566849 7612091 17636609 20502296 10831982 10796159 16883446 12850607 8760703 12738150 12972015 15970823 17636610 8598837 7485346
11	FLT1	Fms Related Tyrosine Kinase 1	Protein Coding	22.64	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	16148081 12454810
12	IL1RN	Interleukin 1 Receptor Antagonist	Protein Coding	22.47	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	7506905 8838971
13	IL1A	Interleukin 1 Alpha	Protein Coding	22	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
14	CCL2	C-C Motif Chemokine Ligand 2	Protein Coding	21.71	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
15	MMP9	Matrix Metallopeptidase 9	Protein Coding	21.64	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)

Sources

Variations for Chorioamnionitis

Sources

Expression for Chorioamnionitis

Search GEO for disease gene expression data for Chorioamnionitis.

Sources

Pathways for Chorioamnionitis

Pathways related to Chorioamnionitis according to GeneCards Suite gene sharing:

(show top 50) (show all 84)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁶ Show member pathways Immune System ⁶⁶ Neutrophil degranulation ⁶⁶	14.04	CCL2 CRP CXCL8 ELANE IL1A IL1B
2	PEDF Induced Signaling ⁶⁴ Show member pathways all-trans-Retinoic Acid Signaling in Brain ⁶⁴ Cytokine-cytokine receptor interaction ³⁷ Endothelin-1 Signaling Pathway ⁶⁴ Glucocorticoid Receptor Signaling ⁶⁴ IL-6 Pathway ⁶⁴ MIF Mediated Glucocorticoid Regulation ⁶⁴ MIF Regulation of Innate Immune Cells ⁶⁴ NFAT Signaling and Lymphocyte Interactions ⁶⁴ PGC1Alpha Pathway ⁶⁴ RAR-Gamma-RXR-Alpha Degradation ⁶⁴ STAT3 Pathway ⁶⁴	13.74	CCL2 CXCL8 FLT1 IL1A IL1B IL1R1
3	TGF-Beta Pathway ⁶⁴ Show member pathways JAK-STAT Pathway ⁶⁴ JNK Pathway ⁶⁴ MAPK Family Pathway ⁶⁴ Regulation of eIF4 and p70S6K ⁶⁴ SOCS Pathway ⁶⁴	13.58	CCL2 CXCL8 FLT1 IL1A IL1B IL1R1
4	Akt Signaling ⁶⁴ Show member pathways p38 Signaling ⁶⁴ Tec Kinases Signaling ⁶⁴	13.48	CCL2 CXCL8 FLT1 IL1A IL1B IL1R1
5	Cytokine Signaling in Immune system ⁶⁶ Show member pathways Signaling by Interleukins ⁶⁶	13.43	CCL2 CXCL8 IL1A IL1B IL1R1 IL1RN
6	PAK Pathway ⁶⁴ Show member pathways Antioxidant Action of Vitamin-C ⁶⁴ Epithelial Adherens Junctions ⁶⁴	13.37	CCL2 CXCL8 FLT1 IL1A IL1B IL1R1
7	Human cytomegalovirus infection ³⁷ Show member pathways Hepatitis B ³⁷ Human immunodeficiency virus 1 infection ³⁷ Kaposi sarcoma-associated herpesvirus infection ³⁷	13.14	CCL2 CXCL8 IL1B IL1R1 IL6 MMP9
8	Toll-like Receptor Signaling Pathway ³⁷ ¹ Show member pathways Chagas disease (American trypanosomiasis) ³⁷ NOD-like receptor signaling pathway ³⁷ NOD-like Receptor Signaling Pathways ⁶⁵ Regulation of toll-like receptor signaling pathway ¹	13.06	CCL2 CXCL8 IL1B IL6 TLR4 TNF
9	Allograft rejection ¹ ³⁷ Show member pathways Antigen processing and presentation ³⁷ Asthma ³⁷ Autoimmune thyroid disease ³⁷ CTL Mediated Apoptosis ⁶⁴ Graft-versus-host disease ³⁷ Intestinal immune network for IgA production ³⁷ THC Differentiation Pathway ⁶⁴ Type I diabetes mellitus ³⁷ Viral myocarditis ³⁷	12.89	CXCL8 IL1A IL1B IL6 TNF
10	Influenza A ³⁷ Show member pathways Herpes simplex infection ³⁷ Measles ³⁷	12.89	CCL2 CXCL8 IL1A IL1B IL6 TLR4
11	MAPK signaling pathway ³⁷ ¹	12.81	FLT1 IL1A IL1B IL1R1 TNF
12	RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways ⁶⁶ Show member pathways Cytosolic DNA-sensing pathway ³⁷ Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway ²² Negative regulators of RIG-I/MDA5 signaling ⁶⁶ NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 ⁶⁶ RIG-I-like Receptor Signaling ¹ RIG-I-like receptor signaling pathway ³⁷ TRAF3-dependent IRF activation pathway ⁶⁶ TRAF6 mediated IRF7 activation ⁶⁶ Virus Detection and Induction of Antiviral Signaling Pathways by RIG-I-like Receptors (RLR) ⁶⁵	12.81	CXCL8 IL1B IL6 TLR4 TNF
13	NF-KappaB Family Pathway ⁶⁴ Show member pathways NF-KappaB (p50-p65) Pathway ⁶⁴	12.79	FLT1 IL1A IL1B IL1R1 IL6 TLR4
14	TRAF Pathway ⁶⁴ Show member pathways 14-3-3 Induced Apoptosis ⁶⁴ TNF Superfamily Pathway ⁶⁴ Toll-Like Receptors Pathway ⁶⁴	12.72	FLT1 IL1A IL1B IL1R1 TLR4 TNF
15	Th17 cell differentiation ³⁷ Show member pathways IL-22 Pathway ⁶⁴ Immune response IL-22 signaling pathway ²² Inflammatory bowel disease (IBD) ³⁷ Th1 and Th2 cell differentiation ³⁷	12.71	IL1A IL1B IL1R1 IL6 TLR4 TNF
16	Immune response IL-23 signaling pathway ²² Show member pathways Angiopoietin receptor Tie2-mediated signaling ¹ Angiopoietin-TIE2 Signaling ⁶⁴ Development Angiopoietin - Tie2 signaling ²² Development PDGF signaling via STATs and NF-kB ²² IL23-mediated signaling events ¹ Immune response IL-10 signaling pathway ²² Rac1/Pak1/p38/MMP-2 pathway ¹	12.6	CCL2 IL1B IL6 TNF
17	NF-kappaB Signaling ⁴	12.58	CCL2 IL1B IL1RN TNF
18	Apoptosis Pathway ⁷² Show member pathways Akt Pathway ⁷² NF-kappaB Pathway ⁷²	12.48	FLT1 IL1A IL1B IL1R1
19	T cell receptor signaling pathway ³⁷ Show member pathways T-Cell antigen Receptor (TCR) Signaling Pathway ¹ T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection ¹	12.46	IL1A IL1B IL6 TNF
20	Selenium Micronutrient Network ¹ Show member pathways Folate Metabolism ¹ Metabolism of ingested MeSeO2H into MeSeH ⁶⁶ thioredoxin pathway ¹ Vitamin B12 Metabolism ¹	12.45	CCL2 CRP IL1B IL6 TNF
21	IL-17 Family Signaling Pathways ⁶⁵ Show member pathways IL17 signaling pathway ¹ IL-17 signaling pathway ³⁷ Interleukin-17 signaling ⁶⁶ Mucin expression in CF via IL-6, IL-17 signaling pathways ²²	12.43	CCL2 CXCL8 IL1B IL6 MMP9 TNF
22	IL-1 signaling pathway ¹ Show member pathways IL1-mediated signaling events ¹ Interleukin-1 signaling ⁶⁶ MAP3K8 (TPL2)-dependent MAPK1/3 activation ⁶⁶ Structural Pathway of Interleukin 1 (IL-1) ¹	12.42	CCL2 IL1A IL1B IL1R1 IL1RN
23	Diseases associated with the TLR signaling cascade ⁶⁶ Show member pathways Diseases of Immune System ⁶⁶ Interleukin-1 Induced Activation of NF-kappa-B ¹ IRAK1 recruits IKK complex ⁶⁶ IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation ⁶⁶ IRAK4 deficiency (TLR2/4) ⁶⁶ IRAK4 deficiency (TLR5) ⁶⁶ MyD88 deficiency (TLR2/4) ⁶⁶ MyD88 deficiency (TLR5) ⁶⁶ Simplified Depiction of MYD88 Distinct Input-Output Pathway ¹ TLR4 Signaling and Tolerance ¹ Toll-like Receptor Signaling ¹	12.38	CXCL8 IL1A IL6 TLR4 TNF
24	Immune response IFN alpha/beta signaling pathway ²² Show member pathways Cytokine Network ⁶⁴ Interferon alpha/beta signaling ⁶⁶ Regulation of IFNA signaling ⁶⁶	12.38	CXCL8 FLT1 IL1A IL1B IL6 TNF
25	Toll Comparative Pathway ⁶⁴ Show member pathways IL-1 Pathway ⁶⁴ Immune response MIF in innate immunity response ²² iNOS Signaling ⁶⁴ TLR-TRIF Pathway ⁶⁴	12.38	CXCL8 IL1A IL1B IL1R1 IL6 TLR4
26	Transcriptional misregulation in cancer ³⁷	12.37	CXCL8 ELANE FLT1 IL6 MMP9
27	Tuberculosis ³⁷	12.35	IL1A IL1B IL6 TLR4 TNF
28	Toxoplasmosis ³⁷ Show member pathways Leishmaniasis ³⁷	12.32	IL1A IL1B TLR4 TNF
29	Necroptosis ³⁷ Show member pathways Nanoparticle triggered regulated necrosis ¹	12.28	IL1A IL1B TLR4 TNF
30	Bacterial infections in CF airways ²² Show member pathways IL-1 beta-dependent CFTR expression ²² Immune response Bacterial infections in normal airways ²² Immune response TLR signaling pathways ²²	12.28	CXCL8 IL1B IL1R1 IL6 TLR4 TNF
31	Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways ¹	12.27	CXCL8 IL1A IL1B IL1RN IL6 TNF
32	G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins ²² Show member pathways G-protein signaling G-Protein alpha-12 signaling pathway ²²	12.27	CCL2 CXCL8 IL1A IL1B IL1R1 MMP8
33	IL-1 Family Signaling Pathways ⁶⁵ Show member pathways Immune response IL-1 signaling pathway ²² Mucin expression in CF via TLRs, EGFR signaling pathways ²²	12.27	CXCL8 IL1A IL1B IL1R1 IL1RN IL6
34	Colorectal Cancer Metastasis ⁶⁴	12.26	IL6 MMP9 TLR4 TNF
35	Th1 Differentiation Pathway ⁶⁵ Show member pathways IL27-mediated signaling events ¹ Th17 Differentiation Pathway ⁶⁵	12.18	IL1B IL1R1 IL6 TLR4 TNF
36	Microglia Activation During Neuroinflammation: Overview ⁶⁵ Show member pathways Microglia Activation During Neuroinflammation: Microglia Activation ⁶⁵	12.17	IL1B IL6 MMP9 TLR4 TNF
37	Fluid shear stress and atherosclerosis ³⁷	12.17	CCL2 IL1A IL1B IL1R1 MMP9 TNF
38	Immune response IFN gamma signaling pathway ²² Show member pathways IFN-gamma pathway ¹	12.16	CCL2 CXCL8 FLT1 IL1A IL1B IL1R1
39	Osteoclast differentiation ³⁷	12.13	IL1A IL1B IL1R1 TNF
40	MAPK Pathway ⁷² Show member pathways Toll-like Receptor Pathway ⁷²	12.12	IL1A IL1B IL1R1 TLR4
41	TNF signaling pathway ³⁷	12.09	CCL2 IL1B IL6 MMP9 TNF
42	Senescence and Autophagy in Cancer ¹	12.05	CXCL8 IL1A IL1B IL6
43	Hematopoietic cell lineage ³⁷	12.03	IL1A IL1B IL1R1 IL6 TNF
44	Matrix Metalloproteinases ¹ Show member pathways Activation of Matrix Metalloproteinases ⁶⁶ Inhibition of Matrix Metalloproteinases ⁶⁴	12.01	ELANE MMP8 MMP9 TNF
45	NF-kappa B signaling pathway ³⁷	12.01	CXCL8 IL1B IL1R1 TLR4 TNF
46	AGE-RAGE signaling pathway in diabetic complications ³⁷	12	CCL2 CXCL8 IL1A IL1B IL6 TNF
47	Salmonella infection (KEGG) ³⁷	11.95	CXCL8 IL1A IL1B IL6 TLR4
48	Amoebiasis ³⁷	11.95	CXCL8 IL1B IL1R1 IL6 TLR4 TNF
49	HIF-1 signaling pathway ³⁷	11.94	FLT1 IL6 TLR4
50	Cytokine production by Th17 cells in CF (Mouse model) ²² Show member pathways Cytokine production by Th17 cells in CF ²²	11.9	CXCL8 IL6 TLR4

Sources

GO Terms for Chorioamnionitis

Cellular components related to Chorioamnionitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	9.77	CCL2 CRP CXCL8 ELANE FLT1 IL1A
2	extracellular region	GO:0005576	9.47	CCL2 CRP CXCL8 ELANE FLT1 IL1A
3	secretory granule	GO:0030141	9.33	ELANE IL1B OXT

Biological processes related to Chorioamnionitis according to GeneCards Suite gene sharing:

(show top 50) (show all 66)

#	Name	GO ID	Score	Top Affiliating Genes
1	leukocyte migration	GO:0050900	9.99	ELANE IL1B MMP9 TNF
2	positive regulation of I-kappaB kinase/NF-kappaB signaling	GO:0043123	9.97	IL1B IL1RN TLR4 TNF
3	positive regulation of angiogenesis	GO:0045766	9.95	CXCL8 FLT1 IL1A IL1B
4	positive regulation of NF-kappaB transcription factor activity	GO:0051092	9.93	IL1B IL6 TLR4 TNF
5	activation of MAPK activity	GO:0000187	9.91	IL1B TLR4 TNF
6	immune response	GO:0006955	9.91	CCL2 CXCL8 IL1A IL1B IL1R1 IL1RN
7	positive regulation of DNA-binding transcription factor activity	GO:0051091	9.9	IL1B IL6 TNF
8	defense response to Gram-positive bacterium	GO:0050830	9.89	CRP IL6 TNF
9	memory	GO:0007613	9.89	IL1B IL1RN OXT
10	cellular response to organic cyclic compound	GO:0071407	9.89	CCL2 IL1B TNF
11	neutrophil chemotaxis	GO:0030593	9.89	CCL2 CXCL8 IL1B IL1RN
12	regulation of inflammatory response	GO:0050727	9.88	IL1R1 TLR4 TNF
13	positive regulation of MAP kinase activity	GO:0043406	9.87	ELANE FLT1 TNF
14	extracellular matrix disassembly	GO:0022617	9.87	ELANE MMP8 MMP9
15	humoral immune response	GO:0006959	9.87	CCL2 IL6 TNF
16	positive regulation of NIK/NF-kappaB signaling	GO:1901224	9.87	IL1B MMP8 TLR4 TNF
17	cellular response to lipopolysaccharide	GO:0071222	9.87	CCL2 CXCL8 IL1B IL1RN IL6 TLR4
18	positive regulation of smooth muscle cell proliferation	GO:0048661	9.86	ELANE IL6 TNF
19	interleukin-1-mediated signaling pathway	GO:0070498	9.86	IL1A IL1B IL1R1 IL1RN
20	positive regulation of JNK cascade	GO:0046330	9.85	IL1B IL1RN MMP8 TLR4 TNF
21	monocyte chemotaxis	GO:0002548	9.84	CCL2 FLT1 IL6
22	positive regulation of interferon-gamma production	GO:0032729	9.84	IL1B IL1R1 TLR4 TNF
23	positive regulation of JUN kinase activity	GO:0043507	9.83	IL1B IL1RN TNF
24	protein kinase B signaling	GO:0043491	9.83	CCL2 IL1B TNF
25	positive regulation of nitric oxide biosynthetic process	GO:0045429	9.83	IL1B MMP8 TLR4 TNF
26	response to glucocorticoid	GO:0051384	9.83	IL1B IL1RN IL6 OXT TNF
27	lipopolysaccharide-mediated signaling pathway	GO:0031663	9.81	CCL2 IL1B TLR4 TNF
28	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	GO:2001240	9.8	IL1A IL1B TNF
29	positive regulation of interleukin-8 production	GO:0032757	9.79	IL1B TLR4 TNF
30	negative regulation of neurogenesis	GO:0050768	9.79	IL1B IL6 TNF
31	positive regulation of chemokine production	GO:0032722	9.77	IL6 TLR4 TNF
32	positive regulation of glial cell proliferation	GO:0060252	9.76	IL1B IL6 TNF
33	positive regulation of interleukin-8 biosynthetic process	GO:0045416	9.75	ELANE TLR4 TNF
34	embryonic digestive tract development	GO:0048566	9.74	CXCL8 TNF
35	negative regulation of lipid catabolic process	GO:0050995	9.74	IL1B TNF
36	regulation of I-kappaB kinase/NF-kappaB signaling	GO:0043122	9.73	IL1B TNF
37	positive regulation of membrane protein ectodomain proteolysis	GO:0051044	9.73	IL1B TNF
38	negative regulation of growth of symbiont in host	GO:0044130	9.73	ELANE TNF
39	positive regulation of heterotypic cell-cell adhesion	GO:0034116	9.73	IL1B TNF
40	positive regulation of nitric-oxide synthase biosynthetic process	GO:0051770	9.72	CCL2 TLR4
41	positive regulation of reactive oxygen species biosynthetic process	GO:1903428	9.72	MMP8 TLR4
42	positive regulation of interleukin-2 biosynthetic process	GO:0045086	9.72	IL1A IL1B
43	PERK-mediated unfolded protein response	GO:0036499	9.72	CCL2 CXCL8
44	negative regulation of lipid storage	GO:0010888	9.72	CRP IL6 TNF
45	positive regulation of chemokine biosynthetic process	GO:0045080	9.71	IL1B TNF
46	ectopic germ cell programmed cell death	GO:0035234	9.71	IL1A IL1B
47	negative regulation of glutamate secretion	GO:0014050	9.7	IL1B IL1RN
48	positive regulation of prostaglandin secretion	GO:0032308	9.7	IL1B OXT
49	regulation of establishment of endothelial barrier	GO:1903140	9.7	IL1B TNF
50	negative regulation of interleukin-1-mediated signaling pathway	GO:2000660	9.68	IL1RN IL6

Molecular functions related to Chorioamnionitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protease binding	GO:0002020	9.43	ELANE IL1R1 TNF
2	endopeptidase activity	GO:0004175	9.33	ELANE MMP8 MMP9
3	cytokine activity	GO:0005125	9.17	CCL2 CXCL8 IL1A IL1B IL1RN IL6
4	interleukin-1 receptor binding	GO:0005149	9.13	IL1A IL1B IL1RN

Sources

Sources for Chorioamnionitis

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⁷¹ TGDB

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⁷⁶ Wikipedia