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MCID: CHR005
MIFTS: 50

Chorioamnionitis

Categories: Fetal diseases, Infectious diseases, Reproductive diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Chorioamnionitis

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MalaCards integrated aliases for Chorioamnionitis:

Name: Chorioamnionitis 12 54 44 15 17 71

Classifications:

MalaCards categories:
Global: Fetal diseases Infectious diseases
Anatomical: Reproductive diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:0050697
MeSH 44 D002821
UMLS 71 C0008495
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Summaries for Chorioamnionitis

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Disease Ontology : 12 A placenta disease that is an inflammation of the fetal membranes (amnion and chorion) due to a bacterial infection.

MalaCards based summary : Chorioamnionitis is related to listeriosis and funisitis. An important gene associated with Chorioamnionitis is IL6 (Interleukin 6), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Clindamycin and Gentamicins have been mentioned in the context of this disorder. Affiliated tissues include placenta, brain and uterus, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 74 Chorioamnionitis, also known as intra-amniotic infection (IAI), is an inflammation of the fetal... more...

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Related Diseases for Chorioamnionitis

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Diseases related to Chorioamnionitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 817)
# Related Disease Score Top Affiliating Genes
1 listeriosis 31.8 TNF IL6 IL1B IL10
2 funisitis 31.2 TNF S100A12 OXT MMP8 IL6 IL1B
3 periventricular leukomalacia 31.2 TNF IL6 IL1R1
4 bronchopulmonary dysplasia 31.0 IL1RN FLT1 ELANE CXCL8
5 endometritis 30.8 TNF TLR4 OXT IL6 IL1B CXCL8
6 vasculitis 30.8 TNF IL6 ELANE CRP CCL2
7 cerebral palsy 30.7 TNF TLR4 MMP8 IL6 IL1B IL10
8 enterocolitis 30.6 TNF TLR4 IL6 IL10 CXCL8 CRP
9 urinary tract infection 30.5 TLR4 CRP
10 pain agnosia 30.4 TNF OXT IL6 IL1B
11 haemophilus influenzae 30.4 TNF CXCL8
12 perinatal necrotizing enterocolitis 30.4 TNF TLR4 IL6 IL1B IL10 CXCL8
13 meconium aspiration syndrome 30.3 TNF OXT IL6 CXCL8
14 eclampsia 30.3 VEGFA TNF OXT FLT1
15 asphyxia neonatorum 30.3 OXT IL6 IL1B CRP
16 exudative vitreoretinopathy 1 30.3 VEGFA TNF IL6 IL1B FLT1 CXCL8
17 preterm premature rupture of the membranes 30.2 TNF TLR4 OXT MMP9 MMP8 IL6
18 fasciitis 30.2 TNF IL6 IL1RN CXCL8
19 septic arthritis 30.1 TREM1 TLR4 CXCL8 CRP
20 bacteriuria 30.1 TLR4 IL6 CXCL8 CRP CCL2
21 candidiasis 30.0 TNF TLR4 IL6 IL1B IL10 CXCL8
22 necrotizing fasciitis 30.0 IL6 IL1RN IL1B CXCL8 CRP
23 thrombocytosis 30.0 IL6 IL1B IL1A CRP
24 placenta accreta 30.0 VEGFA OXT FLT1
25 graft-versus-host disease 30.0 TNF IL6 IL1B IL1A IL10
26 allergic disease 29.9 TNF TLR4 IL6 IL1B
27 vaginal discharge 29.9 TNF OXT IL6 IL1B IL10 CXCL8
28 vaginitis 29.8 TNF IL6 IL1B IL1A IL10 CXCL8
29 placental insufficiency 29.8 VEGFA IL6 FLT1 CXCL8
30 conjunctivitis 29.8 TNF MMP9 IL6 IL10 CXCL8 CCL2
31 tetanus 29.8 TNF IL6 IL1B IL1A IL10 CRP
32 chlamydia 29.8 TNF TLR4 IL6 IL1B IL1A IL10
33 bacterial vaginosis 29.8 TNF TLR4 MMP8 IL6 IL1RN IL1B
34 trichomoniasis 29.8 TNF IL6 IL1B IL10 CXCL8
35 cervicitis 29.8 TNF TLR4 IL6 IL1B IL10 CXCL8
36 food allergy 29.7 TNF TLR4 IL10 CXCL8
37 adenomyosis 29.7 VEGFA OXT MMP9 IL6 CXCL8
38 disseminated intravascular coagulation 29.7 TNF IL6 IL10 HMGB1 ELANE CRP
39 severe pre-eclampsia 29.7 VEGFA TLR4 MMP9
40 dermatitis 29.6 TNF IL6 IL1B IL1A IL10 CXCL8
41 rubella 29.6 TNF TLR4 IL6 IL1B IL10
42 toxoplasmosis 29.6 TNF TLR4 IL6 IL1B IL10
43 endometriosis 29.6 VEGFA IL6 IL1B CXCL8 CCL2
44 endocarditis 29.6 TNF IL6 IL1A IL10 CXCL8 CRP
45 pulmonary edema 29.6 TNF OXT IL1B IL10 CXCL8 CRP
46 ileus 29.6 TNF IL6 IL1B IL10 CRP CCL2
47 intestinal perforation 29.6 VEGFA TNF TLR4 IL6 CRP
48 placenta disease 29.6 VEGFA TNF OXT IL6 IL1B FLT1
49 pulmonary emphysema 29.5 VEGFA MMP9 MMP8 ELANE CXCL8
50 hepatitis b 29.5 TNF TLR4 IL6 CXCL8

Graphical network of the top 20 diseases related to Chorioamnionitis:



Diseases related to Chorioamnionitis
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Symptoms & Phenotypes for Chorioamnionitis

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MGI Mouse Phenotypes related to Chorioamnionitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.28 CRP FLT1 IL10 IL1A IL1B IL1R1
2 homeostasis/metabolism MP:0005376 10.22 CRP ELANE FLT1 IL10 IL1A IL1B
3 hematopoietic system MP:0005397 10.18 ELANE FLT1 IL10 IL1A IL1B IL1R1
4 immune system MP:0005387 10.16 CCL2 CRP ELANE FLT1 IL10 IL1A
5 digestive/alimentary MP:0005381 10.01 IL10 IL1R1 IL6 MMP9 OXT TLR4
6 integument MP:0010771 9.93 ELANE IL10 IL1A IL1B IL1R1 IL1RN
7 muscle MP:0005369 9.56 FLT1 IL10 IL1R1 IL6 MMP9 TLR4
8 neoplasm MP:0002006 9.4 ELANE IL10 IL1A IL1B IL1R1 IL6
Sources

Drugs & Therapeutics for Chorioamnionitis

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Drugs for Chorioamnionitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 32)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
2 Gentamicins Phase 4
3 Clindamycin palmitate Phase 4
4 Clindamycin phosphate Phase 4
5
Ampicillin Approved, Vet_approved Phase 2, Phase 3 69-53-4 6249
6
Sulbactam Approved Phase 2, Phase 3 68373-14-8
7
Erythromycin Approved, Investigational, Vet_approved Phase 3 114-07-8 12560
8
Metronidazole Approved Phase 3 443-48-1 4173
9
Nevirapine Approved Phase 3 129618-40-2 4463
10 Antiviral Agents Phase 3
11 Erythromycin Estolate Phase 3
12 Anti-HIV Agents Phase 3
13 Erythromycin stearate Phase 3
14 Reverse Transcriptase Inhibitors Phase 3
15 Antiparasitic Agents Phase 3
16 Erythromycin Ethylsuccinate Phase 3
17 Antiprotozoal Agents Phase 3
18 Anti-Retroviral Agents Phase 3
19 Gastrointestinal Agents Phase 3
20
Acetylcysteine Approved, Investigational Phase 1, Phase 2 616-91-1 12035
21
Acetaminophen Approved Phase 1, Phase 2 103-90-2 1983
22 Respiratory System Agents Phase 1, Phase 2
23 N-monoacetylcystine Phase 1, Phase 2
24 Expectorants Phase 1, Phase 2
25 Antidotes Phase 1, Phase 2
26 Pharmaceutical Solutions Phase 1, Phase 2
27
Oxytocin Approved, Vet_approved 50-56-6 439302 53477758
28
Melatonin Approved, Nutraceutical, Vet_approved 73-31-4 896
29 Protective Agents
30 Antioxidants
31 Fibrinolytic Agents
32 Plasminogen

Interventional clinical trials:

(show all 33)
# Name Status NCT ID Phase Drugs
1 Removal Versus Retention of Cervical Cerclage in Preterm Premature Rupture of Membranes-A Multicenter Randomized Clinical Trial Terminated NCT00201656 Phase 4
2 Treatment Utility of Postpartum Antibiotics in Chorioamnionitis Terminated NCT01585129 Phase 4 Postpartum Antibiotics;No postpartum antibiotics
3 A Randomized Trial in Intrapartum Fever Of No Antibiotics for Low-risk Women (RATIONAL) Withdrawn NCT03168178 Phase 4 Standard Antibiotic Treatment
4 Antibiotic Prophylaxis in Prelabor Rupture of Membranes at Term - a Randomized Controlled Trial Completed NCT01633294 Phase 2, Phase 3 Ampicillin + gentamicin
5 Comparison of Ampicillin / Sulbactam vs. Ampicillin / Gentamicin for Treatment of Intrapartum Chorioamnionitis: a Randomized Controlled Trial Completed NCT00879190 Phase 2, Phase 3 Unasyn;Ampicillin/gentamicin
6 Phase III Trial of Antibiotics to Reduce Chorioamnionitis-Related Perinatal HIV Transmission Completed NCT00021671 Phase 3 Erythromycin;Nevirapine;Ampicillin sodium;Metronidazole
7 Safety of N-acetylcysteine in Maternal Chorioamnionitis Completed NCT00724594 Phase 1, Phase 2 N-acetylcysteine;Control
8 Effect of N-acetylcysteine in Preventing Adverse Neonatal Outcomes in Women With Intra-amniotic Infection/Inflammation Completed NCT00397735 Phase 1, Phase 2 N-acetylcysteine or placebo
9 Maternal Effects of Bacterial Vaginosis (BV) Treatment in Pregnancy (Randomized Trial of BV Treatment in Pregnancy) Completed NCT00153517 Phase 2 oral versus vaginal metronidazole
10 Treatment of Chorioamnionitis After Delivery Unknown status NCT00814905 saline;ampicillin gentamicin;Ampicillin gentamicin clindamycin;ampicillin gentamicin clindamycin
11 Closure of Skin in ChorioAmnionitis Research Pilot Study Unknown status NCT01988168
12 Changes in Blood Flow in MCA of Fetuses to Mothers Having Clinical Chorioamnionitis During Labor Comparing to Fetuses to Healthy Mothers. Unknown status NCT00299637
13 S100B as a Marker for Fetal Brain Injury in Premature Rupture of Membranes Unknown status NCT01778725
14 Core-temperature Monitoring in Patients With PPROM for Early Detection of Chorioamnionitis - a Pilot Study Unknown status NCT02125708
15 Contribution of the Study of Maternal Plasmatic Regulator T Cells and Th17 for the Diagnosis of Acute Chorioanmionitis Among Women Hospitalized for Premature Rupture of Fetal Membranes (PPROM) Between 24 and 34 Gestation Weeks Unknown status NCT01610258
16 Clinical Research: Effect of Chorioamnionitis on Platelet Activation and Placental Vessel Among Preterm Infants by Wnt-Flt1 Signal Pathway Completed NCT03636698
17 PK and PD Modeling of Ampicillin and Gentamicin in Peripartum Patients Completed NCT02427932 Ampicillin;Ampicillin and Gentamicin;Gentamicin
18 Selective Use of Antibiotics in Neonates Born to Mothers With Suspected Chorioamnionitis Completed NCT03576560
19 Comparison of Once Daily Versus 8 Hour Dosing of Gentamicin for the Treatment of Intrapartum Chorioamnionitis Completed NCT00185991 gentamicin
20 A Comparison of Sterile and Non-sterile Gloves for the Incidence of Chorioamnionitis During Labor: a Randomized Controlled Trial Completed NCT01852188
21 Impact of Chorioamnionitis on Maternal and Fetal Levels of Proinflammatory S100A12 Completed NCT02996279
22 Assessment of Labour Progress by Intrapartum Ultrasound: Can it Reduce the Incidence of Chorioamnionitis? Completed NCT04651309
23 Expression Profiling of Bacterial Lipopolysaccharide Activated Neutrophil in Pre-Term, Term Infants and Adults Completed NCT00546195
24 Perinatal Infections and Pregnancy Outcomes in Pakistan: A Collaborative Research Project in Partnership With the University of Alabama, USA Completed NCT00070746
25 Circulating Markers in Preterm Infants With Perinatal and Neonatal Inflammation: An Observational Study Recruiting NCT03320785
26 A Retrospective Chart Review of Newborns With the Presence of Confirmed or Suspected Maternal Chorioamnionitis and Utilization of the Early Onset Sepsis Calculator Recruiting NCT04513691
27 Fetal Heart Rate Variability Analysis for the Early Detection of Chorioamnionitis During Preterm Premature Rupture of Membranes Recruiting NCT02901795
28 Umbilical Cord and Maternal Blood Concentrations of Melatonin, Soluble Urokinase-type Plasminogen Activator Receptor, and Orosomucoid 2 in Pregnancy Complicated by Preterm Premature Rupture of the Membranes and Histological Chorioamnionitis Active, not recruiting NCT04588220
29 Umbilical Cord and Maternal Blood Concentrations of Matrix Metalloproteinase 14, Neopterin, and Orosomucoid 1 in Pregnancy Complicated by Preterm Premature Rupture of the Membranes and Histological Chorioamnionitis Active, not recruiting NCT04532021
30 Comparison Between Two Protocols for Management of Prelabor Rupture of the Membranes at Term Not yet recruiting NCT04307069 Oxytocin
31 Effects of Intentional Delivery After Preterm and Prelabor Rupture of Membranes Between 32 and 35 Weeks of Gestation: A Multicentre Randomized and Controlled Trial Terminated NCT00259519
32 Kinetics of Inflammation Markers in Maternal Plasma (Interleukins, Matrix Metalloproteinases -MMP): Study of the Correlation With the Diagnosis of Chorioamnionitis in Women Hospitalized for Spontaneous Rupture of the Fetal Membranes (SPROM) Before 34 Weeks of Amenorrhea (WA) With no Modification in the Usual Therapy. Terminated NCT01903759
33 Chorioamnionitis: Observation of at Risk Infants vs Standard Care. Randomized Controlled Trial. Withdrawn NCT02886910

Search NIH Clinical Center for Chorioamnionitis

Cochrane evidence based reviews: chorioamnionitis

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Genetic Tests for Chorioamnionitis

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Anatomical Context for Chorioamnionitis

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MalaCards organs/tissues related to Chorioamnionitis:

40
Placenta, Brain, Uterus, Neutrophil, Heart, Cervix, Fetal Lung
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Publications for Chorioamnionitis

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Articles related to Chorioamnionitis:

(show top 50) (show all 4087)
# Title Authors PMID Year
1
Labor induction with a Foley balloon inflated to 30 mL compared with 60 mL: a randomized controlled trial. 61 54
20502296 2010
2
IL-6 and TNFalpha across the umbilical circulation in term pregnancies: relationship with labour events. 61 54
20171025 2010
3
Accuracy of C-reactive protein determination in predicting chorioamnionitis and neonatal infection in pregnant women with premature rupture of membranes: a systematic review. 54 61
19819609 2009
4
Intravenous oxytocin alone for cervical ripening and induction of labour. 61 54
19821304 2009
5
The association between intrauterine inflammation and spontaneous vaginal delivery at term: a cross-sectional study. 54 61
19668329 2009
6
Using proteomics in perinatal and neonatal sepsis: hopes and challenges for the future. 61 54
19395960 2009
7
Inflammatory cytokine mRNA detection by real time PCR in chorioamniotic membranes from pregnant women with preterm premature rupture of membranes. 54 61
19272692 2009
8
Mechanisms of leukocyte accumulation and activation in chorioamnionitis: interleukin 1 beta and tumor necrosis factor alpha enhance colony stimulating factor 2 expression in term decidua. 54 61
19164476 2009
9
[Local expression of tumor necrosis factor-alpha on premature rupture of membranes]. 61 54
19669033 2009
10
Intra-amniotic LPS modulation of TLR signaling in lung and blood monocytes of fetal sheep. 54 61
19318420 2009
11
Uncultivated bacteria as etiologic agents of intra-amniotic inflammation leading to preterm birth. 54 61
18971361 2009
12
Lipopolysaccharide binding protein in the early diagnosis of intraamniotic infection of pregnant women with premature rupture of the membranes. 61 54
18783308 2009
13
Value of amniotic fluid interleukin-8 for the prediction of histological chorioamnionitis in preterm premature rupture of membranes. 61 54
20038922 2009
14
[Relationship among TNF-alpha gene promoter -308 site polymorphism, the levels of maternal serum TNF-alpha, and the mRNA expression placental TNF-alpha in preterm labor]. 54 61
19292050 2009
15
[The assessment of neutrophil elastase measurements usefulness in pregnant women with premature rupture of fetal membranes and chorioamnionitis suspicion]. 54 61
19323055 2009
16
Fetal umbilical cord blood erythropoietin, interleukin-6, pH, pO(2), pCO(2), and base excess levels in histologic and/or clinical chorioamnionitis: is the response only inflammatory? 54 61
19842878 2009
17
Severe neonatal hypoxic respiratory failure correlates with histological chorioamnionitis and raised concentrations of interleukin 6 (IL6), IL8 and C-reactive protein. 54 61
18192328 2008
18
First-trimester maternal plasma concentrations of C-reactive protein in low-risk patients and the subsequent development of chorioamnionitis. 54 61
18938289 2008
19
Haplotypes of tumor necrosis factor gene and tracheal aspirate fluid levels of tumor necrosis factor-alpha in preterm infants. 61 54
18645461 2008
20
Interleukin-6 polymorphism is associated with chorioamnionitis and neonatal infections in preterm infants. 61 54
18571528 2008
21
Nucleated red blood cells are a direct response to mediators of inflammation in newborns with early-onset neonatal sepsis. 61 54
18395034 2008
22
[Cord blood levels of interleukin 6 in preterm infants as an early marker of neonatal morbidity]. 54 61
18358131 2008
23
Using proteomic analysis of the human amniotic fluid to identify histologic chorioamnionitis. 61 54
18238979 2008
24
Fetal cortisol response to intrauterine microbial colonisation identified by the polymerase chain reaction and fetal inflammation. 61 54
17405871 2008
25
Progestin-inflammatory cytokine interactions affect matrix metalloproteinase-1 and -3 expression in term decidual cells: implications for treatment of chorioamnionitis-induced preterm delivery. 61 54
17940116 2008
26
Increased production of beta-defensin 3 (hBD-3) by human amniotic epithelial cells (HAEC) after activation of toll-like receptor 4 in chorioamnionitis. 54 61
18345485 2008
27
WITHDRAWN: Oxytocin for prelabour rupture of membranes at or near term. 54 61
17636608 2007
28
Use of C-reactive protein as a predictor of chorioamnionitis in preterm prelabour rupture of membranes: a systematic review. 61 54
17567416 2007
29
WITHDRAWN: Prostaglandins versus oxytocin for prelabour rupture of membranes at or near term. 61 54
17636609 2007
30
WITHDRAWN: Prostaglandins versus oxytocin for prelabour rupture of membranes at term. 61 54
17636610 2007
31
Perfusion with lipopolysaccharide differently affects the secretion of tumor necrosis factor-alpha and interleukin-6 by term and preterm human placenta. 61 54
17194482 2007
32
Maternal serum proinflammatory cytokines in preterm labor with intact membranes: neonatal outcome and histological associations. 61 54
17594943 2007
33
LPS induces translocation of TLR4 in amniotic epithelium. 61 54
17055575 2007
34
Maternal plasma interleukin-6, interleukin-1beta and C-reactive protein as indicators of tocolysis failure and neonatal outcome after preterm delivery. 54 61
17437242 2007
35
Toll-like receptor-2 expression in normal and pathologic human placenta. 61 54
17239937 2007
36
Impact of subclinical chorioamnionitis on maternal and neonatal outcomes. 61 54
17364282 2007
37
Delivery outcome after cold-knife conization of the uterine cervix. 54 61
16750257 2006
38
Dermatitis as a component of the fetal inflammatory response syndrome is associated with activation of Toll-like receptors in epidermal keratinocytes. 61 54
17064297 2006
39
IL-6 is constitutively expressed during lung morphogenesis and enhances fetal lung explant branching. 54 61
16988192 2006
40
Role of single nucleotide polymorphisms of cytokine genes in spontaneous preterm delivery. 61 54
17145371 2006
41
The Alabama preterm birth study: corticosteroids and neonatal outcomes in 23- to 32-week newborns with various markers of intrauterine infection. 61 54
17000235 2006
42
[Chorioamnionitis in relation to cord blood sICAM-1 and CRP levels of newborns with and without markers of early onset infection]. 54 61
17426373 2006
43
Tumor necrosis factor-alpha and interleukin-1beta regulate interleukin-8 expression in third trimester decidual cells: implications for the genesis of chorioamnionitis. 61 54
17003486 2006
44
The value of cord blood interleukin-6 levels for predicting chorioamnionitis, funisitis and neonatal infection in term premature rupture of membranes. 61 54
16459014 2006
45
Tumour necrosis factor-alpha converting enzyme in human gestational tissues from pregnancies complicated by chorioamnionitis. 61 54
16376986 2006
46
Predictors of cesarean section following elective post-dates induction of labor in nullipara with uncomplicated singleton vertex pregnancies. 61 54
16883446 2006
47
Multiplex measurement of cytokine/receptor gene polymorphisms and interaction between interleukin-10 (-1082) genotype and chorioamnionitis in extreme preterm delivery. 54 61
16814164 2006
48
Intrauterine inflammation and the onset of peri-intraventricular hemorrhage in premature infants. 54 61
16549908 2006
49
Acute and chronic chorioamnionitis and the risk of perinatal human immunodeficiency virus-1 transmission. 61 54
16389028 2006
50
Amniotic fluid neutrophil elastase and lactate dehydrogenase: association with histologic chorioamnionitis. 54 61
16752257 2006
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Variations for Chorioamnionitis

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Expression for Chorioamnionitis

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Search GEO for disease gene expression data for Chorioamnionitis.
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Pathways for Chorioamnionitis

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Pathways related to Chorioamnionitis according to GeneCards Suite gene sharing:

(show top 50) (show all 88)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 13.98 VEGFA TREM1 TNF TLR4 S100A12 MMP9
2
ERK Signaling 63
Show member pathways
 13.92 VEGFA TNF IL6 IL1R1 IL1B IL1A
3
PEDF Induced Signaling 63
Show member pathways
 13.78 TNF TLR4 IL6 IL1RN IL1R1 IL1B
4
TGF-Beta Pathway 63
Show member pathways
 13.65 VEGFA TNF IL6 IL1R1 IL1B IL1A
5
Akt Signaling 63
Show member pathways
 13.52 TNF TLR4 IL6 IL1R1 IL1B IL1A
6
Cytokine Signaling in Immune system 65
Show member pathways
 13.43 VEGFA TNF MMP9 IL6 IL1RN IL1R1
7
PAK Pathway 63
Show member pathways
 13.42 TNF IL6 IL1R1 IL1B IL1A IL10
8
IL-2 Pathway 63
Show member pathways
 13.29 TREM1 TNF TLR4 IL1R1 IL1B IL1A
9
Toll-like Receptor Signaling Pathway 36 1
Show member pathways
 13.15 TREM1 TNF TLR4 MMP9 IL6 IL1B
10
Human cytomegalovirus infection 36
Show member pathways
 13.06 VEGFA TNF TLR4 IL6 IL1R1 IL1B
11
Allograft rejection 36 1
Show member pathways
 12.98 VEGFA TNF IL6 IL1B IL1A IL10
12
Measles 36
Show member pathways
 12.95 TNF TLR4 IL6 IL1B IL1A CXCL8
13
MAPK signaling pathway 36 1
12.88 VEGFA TNF IL1R1 IL1B IL1A FLT1
14
Salmonella infection (KEGG) 36
Show member pathways
 12.86 TNF TLR4 IL6 IL1R1 IL1B CXCL8
15
NF-KappaB Family Pathway 63
Show member pathways
 12.84 TNF TLR4 IL6 IL1R1 IL1B IL1A
16
Toll-Like receptor Signaling Pathways 64
Show member pathways
 12.82 TNF TLR4 IL6 IL1RN IL1R1 IL1B
17
T cell receptor signaling pathway 36
Show member pathways
 12.73 TNF TLR4 IL6 IL1B IL1A IL10
18
Th17 cell differentiation 36
Show member pathways
 12.73 TNF TLR4 IL6 IL1R1 IL1B IL1A
19
Immune response IL-23 signaling pathway 23
Show member pathways
 12.69 TNF IL6 IL1B IL10 CCL2
20
TRAF Pathway 63
Show member pathways
 12.68 TNF TLR4 IL1R1 IL1B IL1A
21
NF-kappaB Signaling 4
12.67 TNF IL1RN IL1B IL10 CCL2
22
Shigellosis 36
12.53 TNF TLR4 IL1R1 IL1B CXCL8
23
IL-17 Family Signaling Pathways 64
Show member pathways
 12.47 TNF MMP9 IL6 IL1B CXCL8 CCL2
24
Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions 64
Show member pathways
 12.46 TNF IL6 IL10 CXCL8 CCL2
25
Folate Metabolism 1
Show member pathways
 12.46 TNF IL6 IL1B CRP CCL2
26
IL-1 signaling pathway 1
Show member pathways
 12.43 IL1RN IL1R1 IL1B IL1A CCL2
27
Toll Comparative Pathway 63
Show member pathways
 12.43 TNF TLR4 IL6 IL1R1 IL1B IL1A
28
Transcriptional misregulation in cancer 36
12.4 MMP9 IL6 FLT1 ELANE CXCL8
29
Immune response IFN alpha/beta signaling pathway 23
Show member pathways
 12.4 TNF IL6 IL1B IL1A IL10 FLT1
30
Diseases associated with the TLR signaling cascade 65
Show member pathways
 12.39 TNF TLR4 IL6 IL1A CXCL8
31
Toxoplasmosis 36
Show member pathways
 12.39 TNF TLR4 IL1B IL1A IL10
32
Proteoglycans in cancer 36
12.38 VEGFA TNF TLR4 MMP9
33
NOD-like receptor signaling pathway 36
12.37 TNF TLR4 IL6 IL1B CXCL8 CCL2
34
Tuberculosis 36
12.36 TNF TLR4 IL6 IL1B IL1A IL10
35
Necroptosis 36
Show member pathways
 12.33 TNF TLR4 IL1B IL1A HMGB1
36
Colorectal Cancer Metastasis 63
12.32 VEGFA TNF TLR4 MMP9 IL6
37
Bacterial infections in CF airways 23
Show member pathways
 12.31 TNF TLR4 IL6 IL1R1 IL1B CXCL8
38
C-type lectin receptor signaling pathway 36
Show member pathways
 12.3 TNF IL6 IL1B IL10
39
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.29 VEGFA TNF IL6 IL1RN IL1B IL1A
40
Fluid shear stress and atherosclerosis 36
12.23 VEGFA TNF MMP9 IL1R1 IL1B IL1A
41
Yersinia infection 36
12.22 TNF TLR4 IL6 IL1B IL10 CXCL8
42
Osteoclast differentiation 36
12.16 TNF IL1R1 IL1B IL1A
43
MAPK Pathway 70
Show member pathways
 12.14 TLR4 IL1R1 IL1B IL1A
44
TNF signaling pathway 36
12.13 TNF MMP9 IL6 IL1B CCL2
45
HIF-1 signaling pathway 36
12.08 VEGFA TLR4 IL6 FLT1
46
NF-kappa B signaling pathway 36
12.08 TNF TLR4 IL1R1 IL1B CXCL8
47
Senescence and Autophagy in Cancer 1
12.07 IL6 IL1B IL1A CXCL8
48
Hematopoietic cell lineage 36
12.06 TNF IL6 IL1R1 IL1B IL1A
49
Amoebiasis 36
12.06 TNF TLR4 IL6 IL1R1 IL1B IL10
50
Matrix Metalloproteinases 1
Show member pathways
 12.04 TNF MMP9 MMP8 ELANE
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GO Terms for Chorioamnionitis

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Cellular components related to Chorioamnionitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.89 VEGFA TNF S100A12 OXT MMP9 MMP8
2 cell surface GO:0009986 9.63 VEGFA TNF TLR4 IL1R1 HMGB1 ELANE
3 extracellular region GO:0005576 9.6 VEGFA TREM1 TNF S100A12 OXT MMP9

Biological processes related to Chorioamnionitis according to GeneCards Suite gene sharing:

(show top 50) (show all 77)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.34 VEGFA TLR4 OXT IL6 IL1RN IL1R1
2 positive regulation of transcription by RNA polymerase II GO:0045944 10.28 VEGFA TNF TLR4 IL6 IL1A IL10
3 neutrophil degranulation GO:0043312 10.15 S100A12 MMP9 MMP8 HMGB1 ELANE
4 negative regulation of cell proliferation GO:0008285 10.14 IL6 IL1B IL1A IL10 CXCL8
5 positive regulation of gene expression GO:0010628 10.09 VEGFA TNF TLR4 MMP8 IL6 IL1B
6 defense response to bacterium GO:0042742 10.07 TNF TLR4 S100A12 IL10 ELANE
7 positive regulation of ERK1 and ERK2 cascade GO:0070374 10.05 VEGFA TNF TLR4 HMGB1 CCL2
8 leukocyte migration GO:0050900 10.04 TREM1 TNF MMP9 ELANE
9 positive regulation of protein phosphorylation GO:0001934 10.04 VEGFA TNF MMP9 IL1B HMGB1
10 response to lipopolysaccharide GO:0032496 10.03 TLR4 IL1B IL10 ELANE
11 positive regulation of NF-kappaB transcription factor activity GO:0051092 10.03 TNF TLR4 S100A12 IL6 IL1B
12 positive regulation of angiogenesis GO:0045766 10.02 VEGFA IL1B IL1A FLT1 CXCL8
13 immune response GO:0006955 10.02 TNF TLR4 IL6 IL1RN IL1R1 IL1B
14 chemotaxis GO:0006935 10.01 HMGB1 FLT1 CXCL8 CCL2
15 positive regulation of DNA-binding transcription factor activity GO:0051091 9.98 TNF IL6 IL1B IL10
16 interleukin-1-mediated signaling pathway GO:0070498 9.96 IL1RN IL1R1 IL1B IL1A
17 positive regulation of inflammatory response GO:0050729 9.96 TNF TLR4 S100A12 IL1B
18 positive regulation of MAPK cascade GO:0043410 9.96 VEGFA MMP8 IL6 HMGB1 FLT1
19 neutrophil chemotaxis GO:0030593 9.93 S100A12 CXCL8 CCL2
20 positive regulation of interferon-gamma production GO:0032729 9.93 TNF TLR4 IL1R1 IL1B
21 regulation of insulin secretion GO:0050796 9.92 TNF IL6 IL1B
22 negative regulation of interleukin-6 production GO:0032715 9.92 TNF TLR4 IL10
23 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.92 VEGFA TNF IL6
24 cellular response to organic cyclic compound GO:0071407 9.92 TNF IL1B CCL2
25 humoral immune response GO:0006959 9.92 TREM1 TNF IL6 CCL2
26 positive regulation of tumor necrosis factor production GO:0032760 9.92 TLR4 MMP8 IL6 IL1A HMGB1
27 extracellular matrix disassembly GO:0022617 9.91 MMP9 MMP8 ELANE
28 positive regulation of smooth muscle cell proliferation GO:0048661 9.91 TNF IL6 ELANE
29 positive regulation of interleukin-1 beta production GO:0032731 9.91 TNF TLR4 IL6 HMGB1
30 positive regulation of JNK cascade GO:0046330 9.91 TNF TLR4 MMP8 IL1B HMGB1
31 positive regulation of cytokine production GO:0001819 9.9 TNF IL1A IL10
32 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.9 TNF MMP9 IL10
33 response to activity GO:0014823 9.9 OXT IL6 IL10
34 positive regulation of cell division GO:0051781 9.89 VEGFA IL1B IL1A
35 negative regulation of interferon-gamma production GO:0032689 9.89 TLR4 IL10 HMGB1
36 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.89 TNF TLR4 MMP8 IL1B HMGB1
37 protein kinase B signaling GO:0043491 9.88 TNF IL1B CCL2
38 positive regulation of chemokine production GO:0032722 9.88 TNF TLR4 IL6
39 positive regulation of nitric oxide biosynthetic process GO:0045429 9.88 TNF TLR4 MMP8 IL1B
40 positive regulation of MAP kinase activity GO:0043406 9.88 VEGFA TNF S100A12 FLT1 ELANE
41 response to glucocorticoid GO:0051384 9.88 TNF OXT IL6 IL1RN IL10 HMGB1
42 acute-phase response GO:0006953 9.87 IL6 IL1RN CRP
43 positive regulation of interleukin-10 production GO:0032733 9.87 TLR4 IL6 HMGB1
44 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.87 TNF IL1B IL1A
45 monocyte chemotaxis GO:0002548 9.87 S100A12 IL6 FLT1 CCL2
46 positive regulation of JAK-STAT cascade GO:0046427 9.86 TNF IL6 IL10
47 positive regulation of DNA binding GO:0043388 9.86 MMP9 MMP8 HMGB1
48 positive regulation of sprouting angiogenesis GO:1903672 9.85 VEGFA IL10 HMGB1
49 positive regulation of vascular endothelial growth factor production GO:0010575 9.85 IL6 IL1B IL1A
50 positive regulation of interleukin-8 production GO:0032757 9.85 TNF TLR4 IL6 IL1B HMGB1 ELANE

Molecular functions related to Chorioamnionitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.32 VEGFA TNF IL6 IL1RN IL1B IL1A
2 interleukin-1 receptor binding GO:0005149 9.13 IL1RN IL1B IL1A
Sources

Sources for Chorioamnionitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
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28 GO
29 GTR
30 HMDB
31 HPO
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35 IUPHAR
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57 OMIM® (Updated 05-Mar-2021)
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63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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