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MCID: CHR005
MIFTS: 53

Chorioamnionitis

Categories: Fetal diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Chorioamnionitis

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MalaCards integrated aliases for Chorioamnionitis:

Name: Chorioamnionitis 12 56 45 15 74

Classifications:

MalaCards categories:
Global: Fetal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:0050697
MeSH 45 D002821
UMLS 74 C0008495
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Summaries for Chorioamnionitis

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Disease Ontology : 12 A placenta disease that is an inflammation of the fetal membranes (amnion and chorion) due to a bacterial infection.

MalaCards based summary : Chorioamnionitis is related to funisitis and cerebral palsy. An important gene associated with Chorioamnionitis is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Cefuroxime and Ampicillin have been mentioned in the context of this disorder. Affiliated tissues include placenta, brain and lung, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 77 Chorioamnionitis also known as intra-amniotic infection (IAI) is an inflammation of the fetal membranes... more...

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Related Diseases for Chorioamnionitis

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Diseases related to Chorioamnionitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 370)
# Related Disease Score Top Affiliating Genes
1 funisitis 31.1 CXCL8 IL1B IL6 MMP8
2 cerebral palsy 30.7 IL1B IL6 MMP8 TNF
3 preterm premature rupture of the membranes 30.6 CRP CXCL8 IL1B IL6 MMP8 MMP9
4 endometritis 30.4 IL1B IL6 OXT TNF
5 eclampsia 30.4 FLT1 OXT TNF
6 haemophilus influenzae 30.4 CXCL8 IL1B TNF
7 melioidosis 30.1 IL6 TLR4 TNF
8 vasculitis 30.1 CCL2 CRP ELANE TNF
9 bronchopulmonary dysplasia 30.0 CXCL8 ELANE FLT1 IL1RN
10 septic arthritis 30.0 CRP CXCL8 TLR4
11 adult respiratory distress syndrome 29.8 CXCL8 ELANE IL6 TNF
12 newborn respiratory distress syndrome 29.8 CXCL8 ELANE IL1B IL6
13 bacterial vaginosis 29.8 CXCL8 IL1A IL1B IL6 TLR4 TNF
14 bacteriuria 29.6 CCL2 CXCL8 IL6 TLR4
15 endometriosis 29.6 CCL2 CXCL8 IL1B IL6
16 toxic shock syndrome 29.5 CXCL8 IL1B IL6 TLR4 TNF
17 otitis media 29.5 CXCL8 IL1B IL6 TLR4 TNF
18 perinatal necrotizing enterocolitis 29.5 CRP CXCL8 IL1B IL6 TLR4 TNF
19 respiratory failure 29.5 CRP CXCL8 ELANE TNF
20 pertussis 29.5 IL1A IL1B IL6 TLR4 TNF
21 appendicitis 29.4 CRP CXCL8 IL1B IL6 MMP8 MMP9
22 lung disease 29.3 CCL2 CXCL8 ELANE IL1B IL6 MMP8
23 chlamydia 29.0 CRP CXCL8 IL1A IL1B IL6 TLR4
24 pneumonia 28.8 CCL2 CRP CXCL8 ELANE IL1B IL6
25 arthritis 28.4 CCL2 CXCL8 IL1A IL1B IL1RN IL6
26 malaria 27.6 CCL2 CRP CXCL8 IL1A IL1B IL1RN
27 asthma 27.4 CCL2 CXCL8 ELANE IL1A IL1B IL1R1
28 listeriosis 11.5
29 retinitis pigmentosa 55 10.5 IL6 TNF
30 angioimmunoblastic lymphadenopathy with dysproteinemia 10.5 IL6 TNF
31 critical limb ischemia 10.5 IL6 TNF
32 papillary conjunctivitis 10.5 CXCL8 IL6
33 tungiasis 10.5 CXCL8 TNF
34 null-cell leukemia 10.5 IL6 TNF
35 autoimmune myocarditis 10.5 IL6 TNF
36 leukomalacia 10.5 IL6 TNF
37 scorpion envenomation 10.5 IL6 TNF
38 cardiogenic shock 10.5 IL6 TNF
39 peptic esophagitis 10.5 CXCL8 IL1B
40 kashin-beck disease 10.5 IL1B TNF
41 burns 10.5 IL1B TNF
42 leukoregulin 10.5 CXCL8 IL1A
43 staphylococcal toxic shock syndrome 10.5 IL1B TNF
44 skin conditions 10.5 IL1A TNF
45 myasthenic syndrome, congenital, 1a, slow-channel 10.5 CRP CXCL8
46 scabies 10.5 CXCL8 IL1A
47 pyuria 10.5 CRP CXCL8
48 cold agglutinin disease 10.5 CRP IL6
49 salpingitis 10.5 CRP TNF
50 drug reaction with eosinophilia and systemic symptoms 10.5 CRP TNF

Graphical network of the top 20 diseases related to Chorioamnionitis:



Diseases related to Chorioamnionitis
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Symptoms & Phenotypes for Chorioamnionitis

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MGI Mouse Phenotypes related to Chorioamnionitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.11 CRP FLT1 IL1A IL1B IL1R1 IL1RN
2 homeostasis/metabolism MP:0005376 10.07 CRP ELANE FLT1 IL1A IL1B IL1R1
3 hematopoietic system MP:0005397 10.02 ELANE FLT1 IL1A IL1B IL1R1 IL1RN
4 immune system MP:0005387 9.97 CCL2 CRP ELANE FLT1 IL1A IL1B
5 integument MP:0010771 9.61 IL1A IL1B IL1R1 IL1RN IL6 MMP9
6 neoplasm MP:0002006 9.28 ELANE IL1A IL1B IL1R1 IL6 MMP8
Sources

Drugs & Therapeutics for Chorioamnionitis

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Drugs for Chorioamnionitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 178)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cefuroxime Approved Phase 4 55268-75-2 5479529 5361202
2
Ampicillin Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 69-53-4 6249
3
Povidone-iodine Approved Phase 4,Not Applicable 25655-41-8
4
Dinoprostone Approved Phase 4,Phase 3,Not Applicable 363-24-6 5280360
5
Clindamycin Approved, Vet_approved Phase 4,Not Applicable 18323-44-9 29029
6
Misoprostol Approved Phase 4,Phase 2,Not Applicable 59122-46-2 5282381
7
Oxytocin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-56-6 53477758 439302
8
Scopolamine Approved, Investigational Phase 4 51-34-3, 6533-68-2 5184
9
Progesterone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 57-83-0 5994
10
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
11
Azithromycin Approved Phase 4,Phase 3,Early Phase 1 83905-01-5 447043 55185
12
Alprostadil Approved, Investigational Phase 4 745-65-3 5280723 149351
13 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
14 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
15 Antitubercular Agents Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1
16 cefuroxime axetil Phase 4
17 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
18 Oxytocics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
19 Clindamycin palmitate Phase 4,Not Applicable
20 Clindamycin phosphate Phase 4,Not Applicable
21 Anti-Ulcer Agents Phase 4,Phase 2,Not Applicable
22 Antacids Phase 4,Phase 2,Not Applicable
23 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Not Applicable
24 Anesthetics Phase 4,Phase 3,Not Applicable
25 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Not Applicable
26 Analgesics Phase 4,Phase 3,Phase 2,Not Applicable
27 Gentamicins Phase 4,Phase 2,Phase 3,Not Applicable
28 Immunologic Factors Phase 4,Phase 2
29 Vaccines Phase 4,Phase 2,Not Applicable
30 Butylscopolammonium Bromide Phase 4
31 Cholinergic Antagonists Phase 4
32 Muscarinic Antagonists Phase 4
33 Autonomic Agents Phase 4,Phase 2,Phase 3
34 Antiemetics Phase 4,Phase 2,Phase 3
35 Adjuvants, Anesthesia Phase 4
36 Bromides Phase 4
37 Parasympatholytics Phase 4
38 Neurotransmitter Agents Phase 4
39 Mydriatics Phase 4
40 Cholinergic Agents Phase 4
41 Anticonvulsants Phase 4,Phase 3
42 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
43 Hormone Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
44 Hormones Phase 4,Phase 3,Phase 2,Not Applicable
45 Progestins Phase 4,Phase 3,Phase 2,Not Applicable
46 Pharmaceutical Solutions Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
47
Sultamicillin Approved, Investigational Phase 2, Phase 3 76497-13-7
48
Sulbactam Approved Phase 2, Phase 3 68373-14-8
49
Metronidazole Approved Phase 3,Phase 2,Phase 1,Not Applicable 443-48-1 4173
50
Nevirapine Approved Phase 3 129618-40-2 4463

Interventional clinical trials:

(show top 50) (show all 193)
# Name Status NCT ID Phase Drugs
1 Comparison of Two Antibiotic Prophylactic Protocols in Preterm Premature Rupture of the Membranes Unknown status NCT02819570 Phase 4 I.V cefuroxime 750 mg*3/d for 2 days;I.V ampicillin 2 gram x4/d for 2 days;P.O cefuroxime 500 mgx2/d for 5 days;P.O roxithromycin 150 mg*2/d for 7 days;P.O moxypen 500 mgx3/d for 5 days
2 Cervical Cerclage for Preventing Spontaneous Preterm Birth in Singleton Pregnancies Without Prior Spontaneous Preterm Birth and With Short Transvaginal Ultrasound Cervical Length Unknown status NCT02746900 Phase 4
3 A Trial of Prostaglandin E2 Tablets Versus Foley Catheter for Labor Induction Unknown status NCT02486679 Phase 4 Prostin (PGE2) tablets
4 Prevention of Very Preterm Delivery by Testing for and Treatment of Bacterial Vaginosis Completed NCT00642980 Phase 4 Clindamycin;Placebo;Clindamycin
5 Randomized Trial Comparing Misoprostol and Foley Bulb for Pregnancy Termination in the Second Trimester Completed NCT00324519 Phase 4 misoprostol
6 Safety and Immunogenicity of Simultaneous Tdap and IIV in Pregnant Women Completed NCT02783170 Phase 4
7 Safety Study of Hyoscine N Butyl Bromide in Active Management of Labor Completed NCT02098889 Phase 4 hyoscine-N-butyl bromide(HBB);Saline
8 Oxytocin Regimen to Prevent Atony and Postpartum Hemorrhage During Vaginal Delivery: 3-arm RCT Completed NCT00790062 Phase 4 Oxytocin
9 A Trial of Oral Misoprostol for Labor Augmentation Completed NCT00906347 Phase 4 Misoprostol;Oxytocin
10 Prevention of Preterm Birth in Pregnant Women at Risk Identified by Ultrasound: Evaluation of Two Treatment Strategies Completed NCT01643980 Phase 4 Vaginal micronized progesterone
11 Induction of Labor With a Foley Balloon Catheter: Inflation With 30ml Compared to 60ml Completed NCT00451308 Phase 4
12 Antibiotic Prophlaxis for High-risk Laboring Women in Low Income Countries Recruiting NCT03248297 Phase 4 Azithromycin;Azithromycin and amoxicillin;Placebo
13 Comparison of Low-dose and High-dose Oxytocin Regimens for Labor Augmentation Recruiting NCT02487797 Phase 4 Oxytocin
14 Foley Bulb With Oral Misoprostol for Induction of Labor Recruiting NCT03407625 Phase 4
15 A Comparison of Oral Misoprostol and Vaginal Misoprostol for Cervical Ripening and Induction of Labor Recruiting NCT02777190 Phase 4 Misoprostol
16 Vaginal Progesterone for the Prolongation of Pregnancy After Arrested Pre-term Labor Recruiting NCT02430233 Phase 4 micronized progesterone 400 mg (Utrogestan)
17 Comparison of Misoprostol Ripening Efficacy With Dilapan Recruiting NCT03670836 Phase 4 Misoprostol
18 Cook Balloon Versus Propess After 12 Hours of Rupture of Membranes Recruiting NCT03310333 Phase 4 Propess® (dinoprostone)
19 The Obese Pitocin Study Recruiting NCT03140488 Phase 4 Oxytocin
20 TRAP Intervention STudy: Early Versus Late Intervention for Twin Reversed Arterial Perfusion Sequence Recruiting NCT02621645 Phase 4
21 Cervical Ripening for Obese Women: A Randomized, Comparative Effectiveness Trial Active, not recruiting NCT02639429 Phase 4 Vaginal Misoprostol
22 Treatment Utility of Postpartum Antibiotics in Chorioamnionitis Terminated NCT01585129 Phase 4 Postpartum Antibiotics;No postpartum antibiotics
23 Removal Versus Retention of Cerclage in Preterm Premature Rupture of Membranes (PPROM) Terminated NCT00201656 Phase 4
24 Buccal Versus Vaginal Misoprostol for Third Trimester Induction of Labor Terminated NCT01519765 Phase 4 Buccal Misoprostol;Vaginal misoprostol
25 Intrapartum Fever: Antibiotics Versus no Treatment Withdrawn NCT03168178 Phase 4 Standard Antibiotic Treatment
26 Bacterial Vaginosis Screening and Treatment to Reduce Infective Complications, Abortion and Preterm Delivery Unknown status NCT00491270 Phase 3
27 Trial of AMNIOECHANGE in Gastroschisis Affected Foetuses Unknown status NCT00127946 Phase 3
28 Cerclage for Singletons With Short Cervix Without Prior Preterm Birth Unknown status NCT02716922 Phase 3
29 Pessary as Adjunctive Therapy to Cerclage for the Prevention of Preterm Birth Unknown status NCT02678026 Phase 3
30 Ampicillin / Sulbactam vs. Ampicillin / Gentamicin for Treatment of Chorioamnionitis Completed NCT00879190 Phase 2, Phase 3 Unasyn;Ampicillin/gentamicin
31 Antibiotics to Reduce Chorioamnionitis-Related Perinatal HIV Transmission Completed NCT00021671 Phase 3 Erythromycin;Nevirapine;Ampicillin sodium;Metronidazole
32 Antibiotic Prophylaxis in Prelabor Rupture of Membranes at Term Completed NCT01633294 Phase 2, Phase 3 Ampicillin + gentamicin
33 Antibiotics Study in Preterm Premature Rupture of the Membranes Completed NCT01401179 Phase 3 cefazolin, erythromycin, clarithromycin
34 Combined Anesthesia for Labor and Maternal Temperature Completed NCT01078519 Phase 3 Combined epidural and spinal anesthesia
35 Induction of Labor in Term Premature Rupture of Membranes: A Comparison Between Oxytocin and Dinoprostone Followed Six Hours Later by Oxytocin Completed NCT01099280 Phase 3 SYNPITAN FORT 5 IU;Propess,SYNPITAN FORT
36 Chlorhexidine Vaginal and Infant Wash in Pakistan Completed NCT00121394 Phase 3
37 Does Vitamins C and E Supplementation of After Preterm Rupture of Membranes Prolong the Duration of Latency? A Prospective Randomized Controlled Study Completed NCT01266928 Phase 3 vitamine C and E
38 Pessary in Singleton Gestations With Short Cervix Without Prior Preterm Birth Completed NCT02716909 Phase 3
39 Beneficial Effects of Antenatal Magnesium Sulfate (BEAM Trial) Completed NCT00014989 Phase 3 magnesium sulfate
40 Trial of Progesterone in Twins and Triplets to Prevent Preterm Birth (STTARS) Completed NCT00099164 Phase 3 17 alpha-hydroxyprogesterone caproate (17P)
41 Reduction of Spontaneous Prematurity by Antibiotic Treatment (Josamycin) Completed NCT00718705 Phase 3 Josamycin;Placebo
42 Effects of ACS in Twin With LPB: Study Protocol for a RCT Recruiting NCT03547791 Phase 2, Phase 3 Betamethason Sodium Phosphate;Normal saline
43 Does a Rescue Course of Betamethasone in Pregnant Women With PPROM Decrease Neonatal Morbidity? Recruiting NCT02939742 Phase 2, Phase 3 Betamethasone;Placebo
44 Comparison of Insulin Alone to Insulin With Metformin to Treat Gestational Diabetes Mellitus Recruiting NCT03651531 Phase 3 Insulin;Metformin
45 Impact of a Booster Course of Antenatal Steroids on Neonatal Outcome in Patients With Premature Rupture of the Membranes Recruiting NCT02469519 Phase 2, Phase 3 Betamethasone - ACTIVE
46 Antenatal Late Preterm Steroids (ALPS): A Randomized Placebo-Controlled Trial Active, not recruiting NCT01222247 Phase 3 Betamethasone;Placebo
47 Oral Probiotic Supplementation in Pregnancy to Reduce Group B Streptococcus Colonization Not yet recruiting NCT03407157 Phase 3
48 Azithromycin-Prevention in Labor Use Study (A-PLUS) Not yet recruiting NCT03871491 Phase 3 Azithromycin;Placebo
49 Progesterone for Maintenance Tocolysis: A Randomized Placebo Controlled Trial Terminated NCT00946088 Phase 2, Phase 3 Progesterone;Polyethylene glycol&hydrogenated vegetable oil.
50 RCT of Progesterone to Prevent Preterm Birth in Nulliparous Women With a Short Cervix Terminated NCT00439374 Phase 3 17 alpha-hydroxyprogesterone caproate

Search NIH Clinical Center for Chorioamnionitis

Cochrane evidence based reviews: chorioamnionitis

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Genetic Tests for Chorioamnionitis

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Anatomical Context for Chorioamnionitis

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MalaCards organs/tissues related to Chorioamnionitis:

42
Placenta, Brain, Lung, Uterus, Cervix, Testes, Colon
Sources

Publications for Chorioamnionitis

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Articles related to Chorioamnionitis:

(show top 50) (show all 954)
# Title Authors Year
1
Causal role of group B Streptococcus-induced acute chorioamnionitis in intrauterine growth retardation and cerebral palsy-like impairments. ( 30626456 )
2019
2
Maternal Serum Interleukin-6: A Non-Invasive Predictor of Histological Chorioamnionitis in Women with Preterm-Prelabor Rupture of Membranes. ( 29635237 )
2019
3
Suspected Chorioamnionitis and Myometrial Contractility: Mechanisms for Increased Risk of Cesarean Delivery and Postpartum Hemorrhage. ( 29848185 )
2019
4
Association between clinical chorioamnionitis and histological funisitis at term. ( 30040750 )
2019
5
Infants Born to Mothers with Clinical Chorioamnionitis: A Cross-Sectional Survey on the Use of Early-Onset Sepsis Risk Calculator and Prolonged Use of Antibiotics. ( 30130819 )
2019
6
Clinical chorioamnionitis at term IX: in vivo evidence of intra-amniotic inflammasome activation. ( 30412466 )
2019
7
Association of chorioamnionitis and its duration with adverse maternal outcomes by mode of delivery: a cohort study. ( 30485648 )
2019
8
Histological chorioamnionitis and developmental outcomes in very preterm infants. ( 30518803 )
2019
9
A Genome-Wide Analysis of Clinical Chorioamnionitis among Preterm Infants. ( 30674050 )
2019
10
Immune biomarkers in maternal plasma to identify histologic chorioamnionitis in women with preterm labor. ( 30706186 )
2019
11
Isolated acute funisitis in the absence of acute chorioamnionitis: What does it mean? ( 30712665 )
2019
12
Maternal peripheral blood platelet-to-white blood cell ratio and platelet count as potential diagnostic markers of histological chorioamnionitis-related spontaneous preterm birth. ( 30714639 )
2019
13
Association of chorioamnionitis and its duration with neonatal morbidity and mortality. ( 30723279 )
2019
14
Histological chorioamnionitis at term according to labor onset: a prospective controlled study. ( 30723280 )
2019
15
Antibody Microarray Analysis of Plasma Proteins for the Prediction of Histologic Chorioamnionitis in Women With Preterm Premature Rupture of Membranes. ( 30727818 )
2019
16
Chorioamnionitis: a reason to deliver but not perform a caesarean. ( 30734473 )
2019
17
Association of a placental Interleukin-6 genetic variant (rs1800796) with DNA methylation, gene expression and risk of acute chorioamnionitis. ( 30795743 )
2019
18
Re: Chorioamnionitis in pregnancy: a comparative study of HIV-positive and HIV-negative parturients. ( 30803410 )
2019
19
The value of amniotic fluid analysis in patients with suspected clinical chorioamnionitis. ( 30817305 )
2019
20
Corrigendum: Chorioamnionitis Is a Risk Factor for Intraventricular Hemorrhage in Preterm Infants: A Systematic Review and Meta-Analysis. ( 30828303 )
2019
21
Management of Chorioamnionitis-Exposed Infants in the Newborn Nursery Using a Clinical Examination-Based Approach. ( 30833294 )
2019
22
Correction: Association of chorioamnionitis and its duration with neonatal morbidity and mortality. ( 30842550 )
2019
23
Successful delayed-interval delivery in the presence of clinical chorioamnionitis in the leading twin: A report of two cases. ( 30846669 )
2019
24
The cost-effectiveness of ertapenem for the treatment of chorioamnionitis after cesarean delivery. ( 30885073 )
2019
25
Chorioamnionitis in Rats Precipitates Extended Postnatal Inflammatory Lymphocyte Hyperreactivity. ( 30921800 )
2019
26
Histological Chorioamnionitis Induces Differential Gene Expression in Human Cord Blood Mononuclear Leukocytes from Term Neonates. ( 30971730 )
2019
27
The prevalence of histologic acute chorioamnionitis among HIV infected pregnant women in Uganda and its association with adverse birth outcomes. ( 30973949 )
2019
28
CXCR2 Blockade Mitigates Neural Cell Injury Following Preclinical Chorioamnionitis. ( 31001130 )
2019
29
Maternal chorioamnionitis & long term neurological morbidity in the offspring. ( 31005407 )
2019
30
Managing Infants Exposed to Maternal Chorioamnionitis by the Use of Early-Onset Sepsis Calculator. ( 31008151 )
2019
31
Protection of the Ovine Fetal Gut against Ureaplasma-Induced Chorioamnionitis: A Potential Role for Plant Sterols. ( 31035616 )
2019
32
Should the diagnostic criteria for suspected clinical chorioamnionitis be changed? ( 31084245 )
2019
33
The combination of maternal blood and amniotic fluid biomarkers improves the predictive accuracy of histologic chorioamnionitis. ( 31103065 )
2019
34
More Maternal Vascular Malperfusion and Chorioamnionitis in Placentas After Expectant Management vs. Immediate Delivery in Fetal Growth Restriction at (Near) Term: A Further Analysis of the DIGITAT Trial. ( 31105647 )
2019
35
Maternal obesity is associated with chorioamnionitis and earlier indicated preterm delivery among expectantly managed women with preterm premature rupture of membranes. ( 28936902 )
2019
36
Discharge breastmilk feeding rates in asymptomatic term newborns admitted to the neonatal intensive care unit for maternal chorioamnionitis. ( 29526120 )
2019
37
Association of Histologic Chorioamnionitis With Perinatal Brain Injury and Early Childhood Neurodevelopmental Outcomes Among Preterm Neonates. ( 29610829 )
2018
38
Clinical Monitoring of Well-Appearing Infants Born to Mothers With Chorioamnionitis. ( 29599112 )
2018
39
Daily gentamicin using ideal body weight demonstrates lower risk of postpartum endometritis and increased chance of successful outcome compared with traditional 8-hour dosing for the treatment of intrapartum chorioamnionitis. ( 29642754 )
2018
40
Chorioamnionitis, neuroinflammation, and injury: timing is key in the preterm ovine fetus. ( 29673373 )
2018
41
Antenatal Vitamin D Preserves Placental Vascular and Fetal Growth in Experimental Chorioamnionitis Due to Intra-amniotic Endotoxin Exposure. ( 29715698 )
2018
42
Concurrent intraoperative uterine rupture and placenta accreta. Do preoperative chronic hypertension, preterm premature rupture of membranes, chorioamnionitis, and placental abruption provide warning to this rare occurrence? ( 29756067 )
2018
43
Incidence of early-onset sepsis in infants born to women with clinical chorioamnionitis. ( 29791315 )
2018
44
In response: Is early onset sepsis risk calculator safe for the management of neonates born to mothers with chorioamnionitis? ( 29795323 )
2018
45
Does maternal chorioamnionitis have to equal antibiotics in an asymptomatic infant? ( 29887607 )
2018
46
Validation of diagnostic tests for histologic chorioamnionitis: Systematic review and meta-analysis. ( 29908373 )
2018
47
The change of fetal heart rate short-term variability during the course of histological chorioamnionitis in fetal sheep. ( 29908375 )
2018
48
Chorioamnionitis exposure dampens the preterm monocyte response to subsequent challenges. ( 29931696 )
2018
49
Subclinical and clinical chorioamnionitis, fetal vasculitis, and risk for preterm birth: A cohort study. ( 29941174 )
2018
50
"Capnocytophaga spp. infection causing chorioamnionitis: an unusual suspect". ( 30031140 )
2018
Sources

Variations for Chorioamnionitis

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Expression for Chorioamnionitis

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Search GEO for disease gene expression data for Chorioamnionitis.
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Pathways for Chorioamnionitis

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Pathways related to Chorioamnionitis according to GeneCards Suite gene sharing:

(show top 50) (show all 83)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 67
Show member pathways
 14.04 CCL2 CRP CXCL8 ELANE IL1A IL1B
2
PEDF Induced Signaling 65
Show member pathways
 13.74 CCL2 CXCL8 FLT1 IL1A IL1B IL1R1
3
TGF-Beta Pathway 65
Show member pathways
 13.57 CCL2 CXCL8 FLT1 IL1A IL1B IL1R1
4
Akt Signaling 65
Show member pathways
 13.48 CCL2 CXCL8 FLT1 IL1A IL1B IL1R1
5
Cytokine Signaling in Immune system 67
Show member pathways
 13.43 CCL2 CXCL8 IL1A IL1B IL1R1 IL1RN
6
PAK Pathway 65
Show member pathways
 13.37 CCL2 CXCL8 FLT1 IL1A IL1B IL1R1
7
Toll-like Receptor Signaling Pathway 1 38
Show member pathways
 13.14 CCL2 CXCL8 IL1B IL6 TLR4 TNF
8
Human cytomegalovirus infection 38
Show member pathways
 13.05 CCL2 CXCL8 IL1B IL1R1 IL6 MMP9
9
Allograft rejection 38 1
Show member pathways
 12.89 CXCL8 IL1A IL1B IL6 TNF
10
MAPK signaling pathway 1 38
12.81 FLT1 IL1A IL1B IL1R1 TNF
11
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways 67
Show member pathways
 12.81 CXCL8 IL1B IL6 TLR4 TNF
12
NF-KappaB Family Pathway 65
Show member pathways
 12.79 FLT1 IL1A IL1B IL1R1 IL6 TLR4
13
TRAF Pathway 65
Show member pathways
 12.72 FLT1 IL1A IL1B IL1R1 TLR4 TNF
14
Th17 cell differentiation 38
Show member pathways
 12.71 IL1A IL1B IL1R1 IL6 TLR4 TNF
15
Immune response IL-23 signaling pathway 23
Show member pathways
 12.59 CCL2 IL1B IL6 TNF
16
T cell receptor signaling pathway 38
Show member pathways
 12.59 IL1A IL1B IL6 TNF
17
NF-kappaB Signaling 4
12.57 CCL2 IL1B IL1RN TNF
18
Apoptosis Pathway 73
Show member pathways
 12.47 FLT1 IL1A IL1B IL1R1
19
Selenium Micronutrient Network 1
Show member pathways
 12.45 CCL2 CRP IL1B IL6 TNF
20
IL-17 Family Signaling Pathways 66
Show member pathways
 12.43 CCL2 CXCL8 IL1B IL6 MMP9 TNF
21
IL-1 signaling pathway 1
Show member pathways
 12.41 CCL2 IL1A IL1B IL1R1 IL1RN
22
Diseases associated with the TLR signaling cascade 67
Show member pathways
 12.38 CXCL8 IL1A IL6 TLR4 TNF
23
Toll Comparative Pathway 65
Show member pathways
 12.38 CXCL8 IL1A IL1B IL1R1 IL6 TLR4
24
Transcriptional misregulation in cancer 38
12.37 CXCL8 ELANE FLT1 IL6 MMP9
25
Immune response IFN alpha/beta signaling pathway 23
Show member pathways
 12.37 CXCL8 FLT1 IL1A IL1B IL6 TNF
26
Tuberculosis 38
12.35 IL1A IL1B IL6 TLR4 TNF
27
Toxoplasmosis 38
Show member pathways
 12.31 IL1A IL1B TLR4 TNF
28
Necroptosis 38
Show member pathways
 12.28 IL1A IL1B TLR4 TNF
29
Bacterial infections in CF airways 23
Show member pathways
 12.28 CXCL8 IL1B IL1R1 IL6 TLR4 TNF
30
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.27 CXCL8 IL1A IL1B IL1RN IL6 TNF
31
G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins 23
Show member pathways
 12.27 CCL2 CXCL8 IL1A IL1B IL1R1 MMP8
32
IL-1 Family Signaling Pathways 66
Show member pathways
 12.27 CXCL8 IL1A IL1B IL1R1 IL1RN IL6
33
Colorectal Cancer Metastasis 65
12.26 IL6 MMP9 TLR4 TNF
34
Th1 Differentiation Pathway 66
Show member pathways
 12.18 IL1B IL1R1 IL6 TLR4 TNF
35
Fluid shear stress and atherosclerosis 38
12.17 CCL2 IL1A IL1B IL1R1 MMP9 TNF
36
Microglia Activation During Neuroinflammation: Overview 66
Show member pathways
 12.16 IL1B IL6 MMP9 TLR4 TNF
37
Immune response IFN gamma signaling pathway 23
Show member pathways
 12.16 CCL2 CXCL8 FLT1 IL1A IL1B IL1R1
38
Osteoclast differentiation 38
12.13 IL1A IL1B IL1R1 TNF
39
MAPK Pathway 73
Show member pathways
 12.11 IL1A IL1B IL1R1 TLR4
40
TNF signaling pathway 38
12.09 CCL2 IL1B IL6 MMP9 TNF
41
Senescence and Autophagy in Cancer 1
12.04 CXCL8 IL1A IL1B IL6
42
NF-kappa B signaling pathway 38
12.04 CXCL8 IL1B IL1R1 TLR4 TNF
43
Hematopoietic cell lineage 38
12.03 IL1A IL1B IL1R1 IL6 TNF
44
Matrix Metalloproteinases 1
Show member pathways
 12.01 ELANE MMP8 MMP9 TNF
45
AGE-RAGE signaling pathway in diabetic complications 38
12 CCL2 CXCL8 IL1A IL1B IL6 TNF
46
Amoebiasis 38
11.95 CXCL8 IL1B IL1R1 IL6 TLR4 TNF
47
Salmonella infection (KEGG) 38
11.94 CXCL8 IL1A IL1B IL6 TLR4
48
HIF-1 signaling pathway 38
11.93 FLT1 IL6 TLR4
49
Cytokine production by Th17 cells in CF (Mouse model) 23
Show member pathways
 11.9 CXCL8 IL6 TLR4
50
Angiogenesis (CST) 4
11.88 CCL2 FLT1 MMP9
Sources

GO Terms for Chorioamnionitis

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Cellular components related to Chorioamnionitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.77 CCL2 CRP CXCL8 ELANE FLT1 IL1A
2 extracellular region GO:0005576 9.47 CCL2 CRP CXCL8 ELANE FLT1 IL1A
3 secretory granule GO:0030141 9.33 ELANE IL1B OXT

Biological processes related to Chorioamnionitis according to GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Name GO ID Score Top Affiliating Genes
1 leukocyte migration GO:0050900 9.99 ELANE IL1B MMP9 TNF
2 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.97 IL1B IL1RN TLR4 TNF
3 positive regulation of angiogenesis GO:0045766 9.95 CXCL8 FLT1 IL1A IL1B
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.93 IL1B IL6 TLR4 TNF
5 activation of MAPK activity GO:0000187 9.91 IL1B TLR4 TNF
6 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.91 CCL2 FLT1 TLR4 TNF
7 immune response GO:0006955 9.91 CCL2 CXCL8 IL1A IL1B IL1R1 IL1RN
8 positive regulation of DNA-binding transcription factor activity GO:0051091 9.9 IL1B IL6 TNF
9 defense response to Gram-positive bacterium GO:0050830 9.89 CRP IL6 TNF
10 neutrophil chemotaxis GO:0030593 9.89 CCL2 CXCL8 IL1B IL1RN
11 cellular response to organic cyclic compound GO:0071407 9.88 CCL2 IL1B TNF
12 regulation of inflammatory response GO:0050727 9.88 IL1R1 TLR4 TNF
13 positive regulation of MAP kinase activity GO:0043406 9.87 ELANE FLT1 TNF
14 extracellular matrix disassembly GO:0022617 9.87 ELANE MMP8 MMP9
15 humoral immune response GO:0006959 9.87 CCL2 IL6 TNF
16 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.87 IL1B MMP8 TLR4 TNF
17 cellular response to lipopolysaccharide GO:0071222 9.87 CCL2 CXCL8 IL1B IL1RN IL6 TLR4
18 positive regulation of smooth muscle cell proliferation GO:0048661 9.86 ELANE IL6 TNF
19 interleukin-1-mediated signaling pathway GO:0070498 9.86 IL1A IL1B IL1R1 IL1RN
20 positive regulation of JNK cascade GO:0046330 9.85 IL1B IL1RN MMP8 TLR4 TNF
21 monocyte chemotaxis GO:0002548 9.84 CCL2 FLT1 IL6
22 positive regulation of interferon-gamma production GO:0032729 9.84 IL1B IL1R1 TLR4 TNF
23 protein kinase B signaling GO:0043491 9.83 CCL2 IL1B TNF
24 positive regulation of nitric oxide biosynthetic process GO:0045429 9.83 IL1B MMP8 TLR4 TNF
25 lipopolysaccharide-mediated signaling pathway GO:0031663 9.81 CCL2 IL1B TLR4 TNF
26 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.8 IL1A IL1B TNF
27 positive regulation of interleukin-8 production GO:0032757 9.79 IL1B TLR4 TNF
28 negative regulation of neurogenesis GO:0050768 9.79 IL1B IL6 TNF
29 positive regulation of chemokine production GO:0032722 9.77 IL6 TLR4 TNF
30 positive regulation of glial cell proliferation GO:0060252 9.76 IL1B IL6 TNF
31 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.75 ELANE TLR4 TNF
32 embryonic digestive tract development GO:0048566 9.74 CXCL8 TNF
33 negative regulation of lipid catabolic process GO:0050995 9.73 IL1B TNF
34 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.73 IL1B TNF
35 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.73 IL1B TNF
36 negative regulation of growth of symbiont in host GO:0044130 9.73 ELANE TNF
37 response to glucocorticoid GO:0051384 9.73 IL1RN IL6 OXT TNF
38 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.72 IL1B TNF
39 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.72 CCL2 TLR4
40 positive regulation of reactive oxygen species biosynthetic process GO:1903428 9.72 MMP8 TLR4
41 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.72 IL1A IL1B
42 negative regulation of lipid storage GO:0010888 9.72 CRP IL6 TNF
43 PERK-mediated unfolded protein response GO:0036499 9.71 CCL2 CXCL8
44 positive regulation of chemokine biosynthetic process GO:0045080 9.71 IL1B TNF
45 ectopic germ cell programmed cell death GO:0035234 9.7 IL1A IL1B
46 positive regulation of prostaglandin secretion GO:0032308 9.7 IL1B OXT
47 regulation of establishment of endothelial barrier GO:1903140 9.7 IL1B TNF
48 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.68 IL1RN IL6
49 positive regulation of fever generation GO:0031622 9.68 IL1B TNF
50 positive regulation of T-helper 1 cell cytokine production GO:2000556 9.68 IL1B IL1R1

Molecular functions related to Chorioamnionitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 9.43 ELANE IL1R1 TNF
2 endopeptidase activity GO:0004175 9.33 ELANE MMP8 MMP9
3 cytokine activity GO:0005125 9.17 CCL2 CXCL8 IL1A IL1B IL1RN IL6
4 interleukin-1 receptor binding GO:0005149 9.13 IL1A IL1B IL1RN
Sources

Sources for Chorioamnionitis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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