MCID: CHR005
MIFTS: 54

Chorioamnionitis

Categories: Fetal diseases

Aliases & Classifications for Chorioamnionitis

MalaCards integrated aliases for Chorioamnionitis:

Name: Chorioamnionitis 12 55 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:0050697
MeSH 44 D002821
UMLS 73 C0008495

Summaries for Chorioamnionitis

Disease Ontology : 12 A placenta disease that is an inflammation of the fetal membranes (amnion and chorion) due to a bacterial infection.

MalaCards based summary : Chorioamnionitis is related to funisitis and preterm premature rupture of the membranes. An important gene associated with Chorioamnionitis is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Cefuroxime and Ampicillin have been mentioned in the context of this disorder. Affiliated tissues include placenta, lung and brain, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 76 Chorioamnionitis also known as intra-amniotic infection (IAI) is an inflammation of the fetal membranes... more...

Related Diseases for Chorioamnionitis

Diseases related to Chorioamnionitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 373)
# Related Disease Score Top Affiliating Genes
1 funisitis 31.0 CXCL8 IL1B IL6 MMP8
2 preterm premature rupture of the membranes 30.7 CRP CXCL8 IL1B IL6 MMP8 MMP9
3 cerebral palsy 30.5 IL1B IL6 MMP8 TNF
4 endometritis 30.3 IL1B IL6 OXT TNF
5 bronchopulmonary dysplasia 30.2 CXCL8 ELANE FLT1 IL1RN
6 haemophilus influenzae 30.2 CXCL8 IL1B TNF
7 vasculitis 30.1 CCL2 CRP ELANE TNF
8 eclampsia 30.0 FLT1 OXT TNF
9 bacterial vaginosis 29.9 CXCL8 IL1A IL1B IL6 TLR4 TNF
10 septic arthritis 29.8 CRP CXCL8 TLR4
11 adult respiratory distress syndrome 29.7 CXCL8 ELANE IL6 TNF
12 newborn respiratory distress syndrome 29.7 CXCL8 ELANE IL1B IL6
13 bacteriuria 29.6 CCL2 CXCL8 IL6 TLR4
14 perinatal necrotizing enterocolitis 29.6 CRP CXCL8 IL1B IL6 TLR4 TNF
15 lung disease 29.6 CCL2 CXCL8 ELANE IL1B IL6 MMP8
16 pre-eclampsia 29.6 FLT1 IL6 OXT TLR4 TNF
17 toxic shock syndrome 29.6 CXCL8 IL1B IL6 TLR4 TNF
18 otitis media 29.6 CXCL8 IL1B IL6 TLR4 TNF
19 appendicitis 29.5 CRP CXCL8 IL1B IL6 MMP8 MMP9
20 pertussis 29.5 IL1A IL1B IL6 TLR4 TNF
21 endometriosis 29.5 CCL2 CXCL8 IL1B IL6
22 respiratory failure 29.5 CRP CXCL8 ELANE TNF
23 chlamydia 29.2 CRP CXCL8 IL1A IL1B IL6 TLR4
24 pneumonia 29.2 CCL2 CRP CXCL8 ELANE IL1B IL6
25 arthritis 29.0 CCL2 CXCL8 IL1A IL1B IL1RN IL6
26 malaria 28.5 CCL2 CRP CXCL8 IL1A IL1B IL1RN
27 asthma 28.1 CCL2 CXCL8 ELANE IL1A IL1B IL1R1
28 listeriosis 11.4
29 retinitis pigmentosa 55 10.3 IL6 TNF
30 angioimmunoblastic lymphadenopathy with dysproteinemia 10.3 IL6 TNF
31 critical limb ischemia 10.3 IL6 TNF
32 papillary conjunctivitis 10.3 CXCL8 IL6
33 brain injury 10.3
34 tungiasis 10.3 CXCL8 TNF
35 null-cell leukemia 10.3 IL6 TNF
36 anca-associated vasculitis 10.3 IL6 TNF
37 leukomalacia 10.3 IL6 TNF
38 scorpion envenomation 10.3 IL6 TNF
39 cardiogenic shock 10.3 IL6 TNF
40 peptic esophagitis 10.3 CXCL8 IL1B
41 kashin-beck disease 10.3 IL1B TNF
42 paraneoplastic syndromes 10.3 IL1B IL6
43 leukoregulin 10.3 CXCL8 IL1A
44 rheumatoid lung disease 10.3 IL1B TNF
45 staphylococcal toxic shock syndrome 10.3 IL1B TNF
46 skin conditions 10.3 IL1A TNF
47 myasthenic syndrome, congenital, 1a, slow-channel 10.3 CRP CXCL8
48 scabies 10.3 CXCL8 IL1A
49 pyuria 10.3 CRP CXCL8
50 cold agglutinin disease 10.3 CRP IL6

Graphical network of the top 20 diseases related to Chorioamnionitis:



Diseases related to Chorioamnionitis

Symptoms & Phenotypes for Chorioamnionitis

MGI Mouse Phenotypes related to Chorioamnionitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.11 CRP FLT1 IL1A IL1B IL1R1 IL1RN
2 homeostasis/metabolism MP:0005376 10.07 CRP ELANE FLT1 IL1A IL1B IL1R1
3 hematopoietic system MP:0005397 10.02 ELANE FLT1 IL1A IL1B IL1R1 IL1RN
4 immune system MP:0005387 9.97 CCL2 CRP ELANE FLT1 IL1A IL1B
5 integument MP:0010771 9.61 IL1A IL1B IL1R1 IL1RN IL6 MMP9
6 neoplasm MP:0002006 9.28 ELANE IL1A IL1B IL1R1 IL6 MMP8

Drugs & Therapeutics for Chorioamnionitis

Drugs for Chorioamnionitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 182)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cefuroxime Approved Phase 4 55268-75-2 5361202 5479529
2
Ampicillin Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 69-53-4 6249
3
Dinoprostone Approved Phase 4,Phase 3,Not Applicable 363-24-6 5280360
4
Clindamycin Approved, Vet_approved Phase 4,Not Applicable 18323-44-9 29029
5
Misoprostol Approved Phase 4,Phase 2,Not Applicable 59122-46-2 5282381
6
Oxytocin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-56-6 439302 53477758
7
Progesterone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 57-83-0 5994
8
Azithromycin Approved Phase 4 83905-01-5 55185 447043
9
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
10
Povidone-iodine Approved Phase 4,Not Applicable 25655-41-8
11
Alprostadil Approved, Investigational Phase 4 745-65-3 149351 5280723
12
Glucosamine Approved, Investigational Phase 4 3416-24-8 439213
13 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Not Applicable
14 cefuroxime axetil Phase 4
15 Anti-Bacterial Agents Phase 4,Phase 2,Phase 3,Not Applicable
16 Antitubercular Agents Phase 4,Phase 2,Phase 3,Not Applicable
17 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
18 Oxytocics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
19 Clindamycin palmitate Phase 4,Not Applicable
20 Clindamycin phosphate Phase 4,Not Applicable
21 Antacids Phase 4,Phase 2,Not Applicable
22 Anti-Ulcer Agents Phase 4,Phase 2,Not Applicable
23 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Not Applicable
24 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Not Applicable
25 Anesthetics Phase 4,Phase 3,Not Applicable
26 Analgesics Phase 4,Phase 3,Phase 2,Not Applicable
27 Gentamicins Phase 4,Phase 2,Phase 3,Not Applicable
28 Mydriatics Phase 4
29 Adjuvants, Anesthesia Phase 4
30 Parasympatholytics Phase 4
31 Scopolamine hydrobromide Phase 4 114-49-8
32 Cholinergic Agents Phase 4
33 Muscarinic Antagonists Phase 4
34 Cholinergic Antagonists Phase 4
35 Neurotransmitter Agents Phase 4
36 Butylscopolammonium Bromide Phase 4
37 Anticonvulsants Phase 4,Phase 3
38 Autonomic Agents Phase 4,Phase 2,Phase 3
39 Bromides Phase 4
40 Immunologic Factors Phase 4,Phase 2
41 Vaccines Phase 4,Phase 2,Not Applicable
42 Progestins Phase 4,Phase 3,Phase 2,Not Applicable
43 Hormones Phase 4,Phase 3,Phase 2,Not Applicable
44 Hormone Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
45 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
46 Pharmaceutical Solutions Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
47 Laxatives Phase 4
48 Carboxymethylcellulose Sodium Phase 4
49 Cathartics Phase 4
50 Glucuronyl glucosamine glycan sulfate Phase 4

Interventional clinical trials:

(show top 50) (show all 183)
# Name Status NCT ID Phase Drugs
1 Comparison of Two Antibiotic Prophylactic Protocols in Preterm Premature Rupture of the Membranes Unknown status NCT02819570 Phase 4 I.V cefuroxime 750 mg*3/d for 2 days;I.V ampicillin 2 gram x4/d for 2 days;P.O cefuroxime 500 mgx2/d for 5 days;P.O roxithromycin 150 mg*2/d for 7 days;P.O moxypen 500 mgx3/d for 5 days
2 A Trial of Prostaglandin E2 Tablets Versus Foley Catheter for Labor Induction Unknown status NCT02486679 Phase 4 Prostin (PGE2) tablets
3 Prevention of Very Preterm Delivery by Testing for and Treatment of Bacterial Vaginosis Completed NCT00642980 Phase 4 Clindamycin;Placebo;Clindamycin
4 Randomized Trial Comparing Misoprostol and Foley Bulb for Pregnancy Termination in the Second Trimester Completed NCT00324519 Phase 4 misoprostol
5 Safety Study of Hyoscine N Butyl Bromide in Active Management of Labor Completed NCT02098889 Phase 4 hyoscine-N-butyl bromide(HBB);Saline
6 Oxytocin Regimen to Prevent Atony and Postpartum Hemorrhage During Vaginal Delivery: 3-arm RCT Completed NCT00790062 Phase 4 Oxytocin
7 A Trial of Oral Misoprostol for Labor Augmentation Completed NCT00906347 Phase 4 Misoprostol;Oxytocin
8 Safety and Immunogenicity of Simultaneous Tdap and IIV in Pregnant Women Completed NCT02783170 Phase 4
9 Prevention of Preterm Birth in Pregnant Women at Risk Identified by Ultrasound: Evaluation of Two Treatment Strategies Completed NCT01643980 Phase 4 Vaginal micronized progesterone
10 Induction of Labor With a Foley Balloon Catheter: Inflation With 30ml Compared to 60ml Completed NCT00451308 Phase 4
11 Antibiotic Prophlaxis for High-risk Laboring Women in Low Income Countries Recruiting NCT03248297 Phase 4 Azithromycin;Azithromycin and amoxicillin;Placebo
12 Cervical Cerclage for Preventing Spontaneous Preterm Birth in Singleton Pregnancies Without Prior Spontaneous Preterm Birth and With Short Transvaginal Ultrasound Cervical Length Recruiting NCT02746900 Phase 4
13 Comparison of Low-dose and High-dose Oxytocin Regimens for Labor Augmentation Recruiting NCT02487797 Phase 4 Oxytocin
14 Cervical Ripening for Obese Women: A Randomized, Comparative Effectiveness Trial Recruiting NCT02639429 Phase 4 Vaginal Misoprostol
15 Foley Bulb With Oral Misoprostol for Induction of Labor Recruiting NCT03407625 Phase 4
16 A Comparison of Oral Misoprostol and Vaginal Misoprostol for Cervical Ripening and Induction of Labor Recruiting NCT02777190 Phase 4 Misoprostol
17 Vaginal Progesterone for the Prolongation of Pregnancy After Arrested Pre-term Labor Recruiting NCT02430233 Phase 4 micronized progesterone 400 mg (Utrogestan)
18 Comparison of Misoprostol Ripening Efficacy With Dilapan Recruiting NCT03670836 Phase 4 Misoprostol
19 Cook Balloon Versus Propess After 12 Hours of Rupture of Membranes Recruiting NCT03310333 Phase 4 Propess® (dinoprostone)
20 The Obese Pitocin Study Recruiting NCT03140488 Phase 4 Oxytocin
21 TRAP Intervention STudy: Early Versus Late Intervention for Twin Reversed Arterial Perfusion Sequence Recruiting NCT02621645 Phase 4
22 Treatment Utility of Postpartum Antibiotics in Chorioamnionitis Terminated NCT01585129 Phase 4 Postpartum Antibiotics;No postpartum antibiotics
23 Removal Versus Retention of Cerclage in Preterm Premature Rupture of Membranes (PPROM) Terminated NCT00201656 Phase 4
24 Buccal Versus Vaginal Misoprostol for Third Trimester Induction of Labor Terminated NCT01519765 Phase 4 Buccal Misoprostol;Vaginal misoprostol
25 Intrapartum Fever: Antibiotics Versus no Treatment Withdrawn NCT03168178 Phase 4 Standard Antibiotic Treatment
26 Bacterial Vaginosis Screening and Treatment to Reduce Infective Complications, Abortion and Preterm Delivery Unknown status NCT00491270 Phase 3
27 Trial of AMNIOECHANGE in Gastroschisis Affected Foetuses Unknown status NCT00127946 Phase 3
28 Pessary as Adjunctive Therapy to Cerclage for the Prevention of Preterm Birth Unknown status NCT02678026 Phase 3
29 Ampicillin / Sulbactam vs. Ampicillin / Gentamicin for Treatment of Chorioamnionitis Completed NCT00879190 Phase 2, Phase 3 Unasyn;Ampicillin/gentamicin
30 Antibiotics to Reduce Chorioamnionitis-Related Perinatal HIV Transmission Completed NCT00021671 Phase 3 Erythromycin;Nevirapine;Ampicillin sodium;Metronidazole
31 Antibiotic Prophylaxis in Prelabor Rupture of Membranes at Term Completed NCT01633294 Phase 2, Phase 3 Ampicillin + gentamicin
32 Antibiotics Study in Preterm Premature Rupture of the Membranes Completed NCT01401179 Phase 3 cefazolin, erythromycin, clarithromycin
33 Combined Anesthesia for Labor and Maternal Temperature Completed NCT01078519 Phase 3 Combined epidural and spinal anesthesia
34 Induction of Labor in Term Premature Rupture of Membranes: A Comparison Between Oxytocin and Dinoprostone Followed Six Hours Later by Oxytocin Completed NCT01099280 Phase 3 SYNPITAN FORT 5 IU;Propess,SYNPITAN FORT
35 Chlorhexidine Vaginal and Infant Wash in Pakistan Completed NCT00121394 Phase 3
36 Does Vitamins C and E Supplementation of After Preterm Rupture of Membranes Prolong the Duration of Latency? A Prospective Randomized Controlled Study Completed NCT01266928 Phase 3 vitamine C and E
37 Pessary in Singleton Gestations With Short Cervix Without Prior Preterm Birth Completed NCT02716909 Phase 3
38 Fetal ST Segment and T Wave Analysis in Labor Completed NCT01131260 Phase 3
39 Beneficial Effects of Antenatal Magnesium Sulfate (BEAM Trial) Completed NCT00014989 Phase 3 magnesium sulfate
40 Trial of Progesterone in Twins and Triplets to Prevent Preterm Birth (STTARS) Completed NCT00099164 Phase 3 17 alpha-hydroxyprogesterone caproate (17P)
41 Reduction of Spontaneous Prematurity by Antibiotic Treatment (Josamycin) Completed NCT00718705 Phase 3 Josamycin;Placebo
42 Cerclage for Singletons With Short Cervix Without Prior Preterm Birth Recruiting NCT02716922 Phase 3
43 Effects of ACS in Twin With LPB: Study Protocol for a RCT Recruiting NCT03547791 Phase 2, Phase 3 Betamethason Sodium Phosphate;Normal saline
44 Does a Rescue Course of Betamethasone in Pregnant Women With PPROM Decrease Neonatal Morbidity? Recruiting NCT02939742 Phase 2, Phase 3 Betamethasone;Placebo
45 Comparison of Insulin Alone to Insulin With Metformin to Treat Gestational Diabetes Mellitus Recruiting NCT03651531 Phase 3 Insulin;Metformin
46 Impact of a Booster Course of Antenatal Steroids on Neonatal Outcome in Patients With Premature Rupture of the Membranes Recruiting NCT02469519 Phase 2, Phase 3 Betamethasone - ACTIVE
47 Antenatal Late Preterm Steroids (ALPS): A Randomized Placebo-Controlled Trial Active, not recruiting NCT01222247 Phase 3 Betamethasone;Placebo
48 Oral Probiotic Supplementation in Pregnancy to Reduce Group B Streptococcus Colonization Not yet recruiting NCT03407157 Phase 3
49 Progesterone for Maintenance Tocolysis: A Randomized Placebo Controlled Trial Terminated NCT00946088 Phase 2, Phase 3 Progesterone;Polyethylene glycol&hydrogenated vegetable oil.
50 A Phase III Efficacy and Safety Study of Intravenous Retosiban Versus Placebo for Women in Spontaneous Preterm Labor Terminated NCT02377466 Phase 3 Retosiban IV infusion;Placebo IV infusion

Search NIH Clinical Center for Chorioamnionitis

Cochrane evidence based reviews: chorioamnionitis

Genetic Tests for Chorioamnionitis

Anatomical Context for Chorioamnionitis

MalaCards organs/tissues related to Chorioamnionitis:

41
Placenta, Lung, Brain, Uterus, Skin, Neutrophil, Heart

Publications for Chorioamnionitis

Articles related to Chorioamnionitis:

(show top 50) (show all 924)
# Title Authors Year
1
Association of Histologic Chorioamnionitis With Perinatal Brain Injury and Early Childhood Neurodevelopmental Outcomes Among Preterm Neonates. ( 29610829 )
2018
2
Incidence of early-onset sepsis in infants born to women with clinical chorioamnionitis. ( 29791315 )
2018
3
The expression of Toll-like receptor 5 in preterm histologic chorioamnionitis. ( 29371755 )
2018
4
Histologic chorioamnionitis in preterm infants: correlation with brain magnetic resonance imaging at term equivalent age. ( 29448926 )
2018
5
Impact of histologic chorioamnionitis on pulmonary hypertension and respiratory outcomes in preterm infants. ( 29480140 )
2018
6
Chorioamnionitis exposure dampens the preterm monocyte response to subsequent challenges. ( 29931696 )
2018
7
Suspected Chorioamnionitis and Myometrial Contractility: Mechanisms for Increased Risk of Cesarean Delivery and Postpartum Hemorrhage. ( 29848185 )
2018
8
Persistent Pulmonary Hypertension and Histologic Chorioamnionitis in Preterm Infants: Controlled Study. ( 29453682 )
2018
9
Prediction of histological chorioamnionitis and neonatal and infantile outcomes using procalcitonin in the umbilical cord blood and amniotic fluid at birth. ( 29315994 )
2018
10
Case Report: Chorioamnionitis and Premature Delivery due to<i>Burkholderia pseudomallei</i>Infection in Pregnancy. ( 29363450 )
2018
11
Intrapartum Management of Chorioamnionitis. ( 29215424 )
2018
12
Daily gentamicin using ideal body weight demonstrates lower risk of postpartum endometritis and increased chance of successful outcome compared with traditional 8-hour dosing for the treatment of intrapartum chorioamnionitis. ( 29642754 )
2018
13
Concurrent intraoperative uterine rupture and placenta accreta. Do preoperative chronic hypertension, preterm premature rupture of membranes, chorioamnionitis, and placental abruption provide warning to this rare occurrence? ( 29756067 )
2018
14
Chorioamnionitis, neuroinflammation, and injury: timing is key in the preterm ovine fetus. ( 29673373 )
2018
15
Exposure to chorioamnionitis alters the monocyte transcriptional response to the neonatal pathogen Staphylococcus epidermidis. ( 29533486 )
2018
16
The Consequences of Preterm Birth and Chorioamnionitis on Brainstem Respiratory Centers: Implications for Neurochemical Development and Altered Functions by Inflammation and Prostaglandins. ( 29449803 )
2018
17
Chorioamnionitis Induces a Specific Signature of Placental ABC Transporters Associated with an Increase of miR-331-5p in the Human Preterm Placenta. ( 29402780 )
2018
18
Validation of diagnostic tests for histologic chorioamnionitis: Systematic review and meta-analysis. ( 29908373 )
2018
19
The change of fetal heart rate short-term variability during the course of histological chorioamnionitis in fetal sheep. ( 29908375 )
2018
20
Clinical Monitoring of Well-Appearing Infants Born to Mothers With Chorioamnionitis. ( 29599112 )
2018
21
Subclinical and clinical chorioamnionitis, fetal vasculitis, and risk for preterm birth: A cohort study. ( 29941174 )
2018
22
In response: Is early onset sepsis risk calculator safe for the management of neonates born to mothers with chorioamnionitis? ( 29795323 )
2018
23
Case report of Staphylococcus epidermidis maternal sepsis and chorioamnionitis following fetoscopy. ( 29055131 )
2018
24
Increased miR-223 expression in foetal organs is a signature of acute chorioamnionitis with systemic consequences. ( 29083107 )
2018
25
Does maternal chorioamnionitis have to equal antibiotics in an asymptomatic infant? ( 29887607 )
2018
26
Discharge breastmilk feeding rates in asymptomatic term newborns admitted to the neonatal intensive care unit for maternal chorioamnionitis. ( 29526120 )
2018
27
Maternal Serum Interleukin-6: A Non-Invasive Predictor of Histological Chorioamnionitis in Women with Preterm-Prelabor Rupture of Membranes. ( 29635237 )
2018
28
Antenatal Vitamin D Preserves Placental Vascular and Fetal Growth in Experimental Chorioamnionitis Due to Intra-amniotic Endotoxin Exposure. ( 29715698 )
2018
29
Daily dosing of gentamicin using ideal body weight for the treatment of intrapartum chorioamnionitis: a pilot study. ( 28349720 )
2018
30
Magnesium sulfate for neuroprotection in the setting of chorioamnionitis. ( 28395549 )
2018
31
Prediction of chorioamnionitis in cases of intraamniotic infection by ureaplasma urealyticum in women with very preterm premature rupture of membranes or preterm labour. ( 28502201 )
2018
32
Maternal Glucose Supplementation in a Murine Model of Chorioamnionitis Alleviates Dysregulation of Autophagy in Fetal Brain. ( 29017418 )
2018
33
Is early-onset sepsis risk calculator safe for the management of neonates born to mothers with chorioamnionitis? ( 29467522 )
2018
34
"Capnocytophaga spp. infection causing chorioamnionitis: an unusual suspect". ( 30031140 )
2018
35
Association between clinical chorioamnionitis and histological funisitis at term. ( 30040750 )
2018
36
Infants Born to Mothers with Clinical Chorioamnionitis: A Cross-Sectional Survey on the Use of Early-Onset Sepsis Risk Calculator and Prolonged Use of Antibiotics. ( 30130819 )
2018
37
Implementation of the sepsis risk score for chorioamnionitis-exposed newborns. ( 30158677 )
2018
38
Lipopolysaccharide-induced chorioamnionitis and postnatal lung injury: The beneficial effects of L-citrulline in newborn rats. ( 30198795 )
2018
39
Applying the neonatal Early-Onset Sepsis calculator in cases of clinical chorioamnionitis at or after 34 weeks of gestation. ( 30201182 )
2018
40
Immunohistochemical demonstration of RECK protein and interleukin-6 in fetal membranes from singleton pregnancies with late preterm delivery, intact membranes and histological chorioamnionitis. ( 30230382 )
2018
41
Vaginal Ureaplasma species increase chorioamnionitis in very preterm infants with preterm premature rupture of the membranes at < 28 weeks of gestation. ( 30244363 )
2018
42
Chorioamnionitis Is a Risk Factor for Intraventricular Hemorrhage in Preterm Infants: A Systematic Review and Meta-Analysis. ( 30271352 )
2018
43
Clinical Chorioamnionitis at Term: New Insights into the Etiology, Microbiology, and the Fetal, Maternal and Amniotic Cavity Inflammatory Responses. ( 30320312 )
2018
44
Chorioamnionitis as a risk factor for retinopathy of prematurity: An updated systematic review and meta-analysis. ( 30332485 )
2018
45
DNA methylation profiling of acute chorioamnionitis-associated placentas and fetal membranes: insights into epigenetic variation in spontaneous preterm births. ( 30373633 )
2018
46
Clinical chorioamnionitis at term IX: in vivo evidence of intra-amniotic inflammasome activation. ( 30412466 )
2018
47
Fetal cord blood and tissue immune responses to chronic placental inflammation and chorioamnionitis. ( 30473713 )
2018
48
Challenging management of chorioamnionitis with placental listeriosis: lessons from 2 cases. ( 30474016 )
2018
49
Association of chorioamnionitis and its duration with adverse maternal outcomes by mode of delivery: a cohort study. ( 30485648 )
2018
50
Histological chorioamnionitis and developmental outcomes in very preterm infants. ( 30518803 )
2018

Variations for Chorioamnionitis

Expression for Chorioamnionitis

Search GEO for disease gene expression data for Chorioamnionitis.

Pathways for Chorioamnionitis

Pathways related to Chorioamnionitis according to GeneCards Suite gene sharing:

(show top 50) (show all 84)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.04 CCL2 CRP CXCL8 ELANE IL1A IL1B
2
Show member pathways
13.74 CCL2 CXCL8 FLT1 IL1A IL1B IL1R1
3
Show member pathways
13.58 CCL2 CXCL8 FLT1 IL1A IL1B IL1R1
4
Show member pathways
13.48 CCL2 CXCL8 FLT1 IL1A IL1B IL1R1
5
Show member pathways
13.43 CCL2 CXCL8 IL1A IL1B IL1R1 IL1RN
6
Show member pathways
13.37 CCL2 CXCL8 FLT1 IL1A IL1B IL1R1
7
Show member pathways
13.14 CCL2 CXCL8 IL1B IL1R1 IL6 MMP9
8
Show member pathways
13.06 CCL2 CXCL8 IL1B IL6 TLR4 TNF
9
Show member pathways
12.89 CXCL8 IL1A IL1B IL6 TNF
10
Show member pathways
12.89 CCL2 CXCL8 IL1A IL1B IL6 TLR4
11 12.81 FLT1 IL1A IL1B IL1R1 TNF
12
Show member pathways
12.81 CXCL8 IL1B IL6 TLR4 TNF
13
Show member pathways
12.79 FLT1 IL1A IL1B IL1R1 IL6 TLR4
14
Show member pathways
12.72 FLT1 IL1A IL1B IL1R1 TLR4 TNF
15
Show member pathways
12.71 IL1A IL1B IL1R1 IL6 TLR4 TNF
16
Show member pathways
12.6 CCL2 IL1B IL6 TNF
17 12.58 CCL2 IL1B IL1RN TNF
18
Show member pathways
12.48 FLT1 IL1A IL1B IL1R1
19
Show member pathways
12.46 IL1A IL1B IL6 TNF
20
Show member pathways
12.45 CCL2 CRP IL1B IL6 TNF
21
Show member pathways
12.43 CCL2 CXCL8 IL1B IL6 MMP9 TNF
22
Show member pathways
12.42 CCL2 IL1A IL1B IL1R1 IL1RN
23
Show member pathways
12.38 CXCL8 IL1A IL6 TLR4 TNF
24
Show member pathways
12.38 CXCL8 FLT1 IL1A IL1B IL6 TNF
25
Show member pathways
12.38 CXCL8 IL1A IL1B IL1R1 IL6 TLR4
26 12.37 CXCL8 ELANE FLT1 IL6 MMP9
27 12.35 IL1A IL1B IL6 TLR4 TNF
28
Show member pathways
12.32 IL1A IL1B TLR4 TNF
29
Show member pathways
12.28 IL1A IL1B TLR4 TNF
30
Show member pathways
12.28 CXCL8 IL1B IL1R1 IL6 TLR4 TNF
31 12.27 CXCL8 IL1A IL1B IL1RN IL6 TNF
32
Show member pathways
12.27 CCL2 CXCL8 IL1A IL1B IL1R1 MMP8
33
Show member pathways
12.27 CXCL8 IL1A IL1B IL1R1 IL1RN IL6
34 12.26 IL6 MMP9 TLR4 TNF
35
Show member pathways
12.18 IL1B IL1R1 IL6 TLR4 TNF
36
Show member pathways
12.17 IL1B IL6 MMP9 TLR4 TNF
37 12.17 CCL2 IL1A IL1B IL1R1 MMP9 TNF
38
Show member pathways
12.16 CCL2 CXCL8 FLT1 IL1A IL1B IL1R1
39 12.13 IL1A IL1B IL1R1 TNF
40
Show member pathways
12.12 IL1A IL1B IL1R1 TLR4
41 12.09 CCL2 IL1B IL6 MMP9 TNF
42 12.05 CXCL8 IL1A IL1B IL6
43 12.03 IL1A IL1B IL1R1 IL6 TNF
44
Show member pathways
12.01 ELANE MMP8 MMP9 TNF
45 12.01 CXCL8 IL1B IL1R1 TLR4 TNF
46 12 CCL2 CXCL8 IL1A IL1B IL6 TNF
47 11.95 CXCL8 IL1A IL1B IL6 TLR4
48 11.95 CXCL8 IL1B IL1R1 IL6 TLR4 TNF
49 11.94 FLT1 IL6 TLR4
50
Show member pathways
11.9 CXCL8 IL6 TLR4

GO Terms for Chorioamnionitis

Cellular components related to Chorioamnionitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.77 CCL2 CRP CXCL8 ELANE FLT1 IL1A
2 extracellular region GO:0005576 9.47 CCL2 CRP CXCL8 ELANE FLT1 IL1A
3 secretory granule GO:0030141 9.33 ELANE IL1B OXT

Biological processes related to Chorioamnionitis according to GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Name GO ID Score Top Affiliating Genes
1 leukocyte migration GO:0050900 9.99 ELANE IL1B MMP9 TNF
2 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.97 IL1B IL1RN TLR4 TNF
3 positive regulation of angiogenesis GO:0045766 9.95 CXCL8 FLT1 IL1A IL1B
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.93 IL1B IL6 TLR4 TNF
5 activation of MAPK activity GO:0000187 9.91 IL1B TLR4 TNF
6 immune response GO:0006955 9.91 CCL2 CXCL8 IL1A IL1B IL1R1 IL1RN
7 positive regulation of DNA-binding transcription factor activity GO:0051091 9.9 IL1B IL6 TNF
8 defense response to Gram-positive bacterium GO:0050830 9.89 CRP IL6 TNF
9 memory GO:0007613 9.89 IL1B IL1RN OXT
10 cellular response to organic cyclic compound GO:0071407 9.89 CCL2 IL1B TNF
11 neutrophil chemotaxis GO:0030593 9.89 CCL2 CXCL8 IL1B IL1RN
12 regulation of inflammatory response GO:0050727 9.88 IL1R1 TLR4 TNF
13 positive regulation of MAP kinase activity GO:0043406 9.87 ELANE FLT1 TNF
14 extracellular matrix disassembly GO:0022617 9.87 ELANE MMP8 MMP9
15 humoral immune response GO:0006959 9.87 CCL2 IL6 TNF
16 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.87 IL1B MMP8 TLR4 TNF
17 cellular response to lipopolysaccharide GO:0071222 9.87 CCL2 CXCL8 IL1B IL1RN IL6 TLR4
18 positive regulation of smooth muscle cell proliferation GO:0048661 9.86 ELANE IL6 TNF
19 interleukin-1-mediated signaling pathway GO:0070498 9.86 IL1A IL1B IL1R1 IL1RN
20 positive regulation of JNK cascade GO:0046330 9.85 IL1B IL1RN MMP8 TLR4 TNF
21 monocyte chemotaxis GO:0002548 9.84 CCL2 FLT1 IL6
22 positive regulation of interferon-gamma production GO:0032729 9.84 IL1B IL1R1 TLR4 TNF
23 positive regulation of JUN kinase activity GO:0043507 9.83 IL1B IL1RN TNF
24 protein kinase B signaling GO:0043491 9.83 CCL2 IL1B TNF
25 positive regulation of nitric oxide biosynthetic process GO:0045429 9.83 IL1B MMP8 TLR4 TNF
26 response to glucocorticoid GO:0051384 9.83 IL1B IL1RN IL6 OXT TNF
27 lipopolysaccharide-mediated signaling pathway GO:0031663 9.81 CCL2 IL1B TLR4 TNF
28 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.8 IL1A IL1B TNF
29 positive regulation of interleukin-8 production GO:0032757 9.79 IL1B TLR4 TNF
30 negative regulation of neurogenesis GO:0050768 9.79 IL1B IL6 TNF
31 positive regulation of chemokine production GO:0032722 9.77 IL6 TLR4 TNF
32 positive regulation of glial cell proliferation GO:0060252 9.76 IL1B IL6 TNF
33 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.75 ELANE TLR4 TNF
34 embryonic digestive tract development GO:0048566 9.74 CXCL8 TNF
35 negative regulation of lipid catabolic process GO:0050995 9.74 IL1B TNF
36 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.73 IL1B TNF
37 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.73 IL1B TNF
38 negative regulation of growth of symbiont in host GO:0044130 9.73 ELANE TNF
39 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.73 IL1B TNF
40 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.72 CCL2 TLR4
41 positive regulation of reactive oxygen species biosynthetic process GO:1903428 9.72 MMP8 TLR4
42 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.72 IL1A IL1B
43 PERK-mediated unfolded protein response GO:0036499 9.72 CCL2 CXCL8
44 negative regulation of lipid storage GO:0010888 9.72 CRP IL6 TNF
45 positive regulation of chemokine biosynthetic process GO:0045080 9.71 IL1B TNF
46 ectopic germ cell programmed cell death GO:0035234 9.71 IL1A IL1B
47 negative regulation of glutamate secretion GO:0014050 9.7 IL1B IL1RN
48 positive regulation of prostaglandin secretion GO:0032308 9.7 IL1B OXT
49 regulation of establishment of endothelial barrier GO:1903140 9.7 IL1B TNF
50 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.68 IL1RN IL6

Molecular functions related to Chorioamnionitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 9.43 ELANE IL1R1 TNF
2 endopeptidase activity GO:0004175 9.33 ELANE MMP8 MMP9
3 cytokine activity GO:0005125 9.17 CCL2 CXCL8 IL1A IL1B IL1RN IL6
4 interleukin-1 receptor binding GO:0005149 9.13 IL1A IL1B IL1RN

Sources for Chorioamnionitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
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49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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