MCID: CHR005
MIFTS: 51

Chorioamnionitis

Categories: Fetal diseases

Aliases & Classifications for Chorioamnionitis

MalaCards integrated aliases for Chorioamnionitis:

Name: Chorioamnionitis 12 55 44 15 17 72

Classifications:



External Ids:

Disease Ontology 12 DOID:0050697
MeSH 44 D002821
UMLS 72 C0008495

Summaries for Chorioamnionitis

Disease Ontology : 12 A placenta disease that is an inflammation of the fetal membranes (amnion and chorion) due to a bacterial infection.

MalaCards based summary : Chorioamnionitis is related to funisitis and cerebral palsy. An important gene associated with Chorioamnionitis is IL6 (Interleukin 6), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Cefuroxime and Cefazolin have been mentioned in the context of this disorder. Affiliated tissues include placenta, lung and brain, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 75 Chorioamnionitis also known as intra-amniotic infection (IAI) is an inflammation of the fetal membranes... more...

Related Diseases for Chorioamnionitis

Diseases related to Chorioamnionitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 425)
# Related Disease Score Top Affiliating Genes
1 funisitis 31.7 MMP8 IL6 IL1B CXCL8
2 cerebral palsy 31.5 TNF MMP8 IL6 IL1B
3 endometritis 31.2 TNF OXT IL6 IL1B
4 haemophilus influenzae 30.9 TNF IL1B CXCL8
5 vaginitis 30.8 IL6 IL1B CXCL8
6 meconium aspiration syndrome 30.8 TNF IL6 CXCL8
7 preterm premature rupture of the membranes 30.8 MMP9 MMP8 IL6 IL1B CXCL8 CRP
8 vasculitis 30.6 TNF ELANE CRP CCL2
9 placenta disease 30.6 OXT IL6 IL1B CXCL8
10 acute cystitis 30.6 IL6 CXCL8 CRP CCL2
11 fasciitis 30.6 TNF IL6 CXCL8
12 eclampsia 30.5 TNF OXT FLT1
13 graft-versus-host disease 30.4 TNF IL6 IL1B IL1A
14 bronchopulmonary dysplasia 30.2 IL1RN FLT1 ELANE CXCL8
15 toxic shock syndrome 30.1 TNF TLR4 IL6 IL1B CXCL8
16 pulmonary edema 30.1 TNF IL1B CXCL8 CRP
17 perinatal necrotizing enterocolitis 30.1 TNF TLR4 IL6 IL1B CXCL8 CRP
18 septic arthritis 30.1 TLR4 CXCL8 CRP
19 respiratory failure 30.0 TNF ELANE CXCL8 CRP
20 endometriosis 30.0 IL6 IL1B CXCL8 CCL2
21 bacterial vaginosis 30.0 TNF TLR4 IL6 IL1B IL1A CXCL8
22 newborn respiratory distress syndrome 30.0 IL6 IL1B ELANE CXCL8
23 adult respiratory distress syndrome 30.0 TNF IL6 ELANE CXCL8
24 pulmonary emphysema 30.0 MMP9 MMP8 ELANE
25 bacteriuria 29.9 TLR4 IL6 CXCL8 CCL2
26 toxoplasmosis 29.9 TNF TLR4 IL6 IL1B
27 necrotizing fasciitis 29.8 IL6 IL1RN CXCL8
28 pertussis 29.7 TNF TLR4 IL6 IL1B IL1A
29 acute respiratory distress syndrome 29.7 TNF IL6 IL1B ELANE CXCL8
30 otitis media 29.6 TNF TLR4 IL6 IL1B CXCL8
31 chlamydia 29.4 TNF TLR4 IL6 IL1B IL1A CXCL8
32 appendicitis 29.4 TNF MMP9 MMP8 IL6 IL1B CXCL8
33 exanthem 29.4 TNF IL6 IL1RN CRP
34 cerebrovascular disease 29.3 TNF TLR4 MMP9 IL6 CRP
35 atherosclerosis susceptibility 29.2 TNF TLR4 IL6 CRP CCL2
36 lung disease 29.2 TNF MMP9 MMP8 IL6 IL1B ELANE
37 bacterial sepsis 29.2 TNF TLR4 ELANE CXCL8 CRP
38 inflammatory bowel disease 29.1 TNF TLR4 IL6 IL1B CXCL8 CRP
39 pyelonephritis 28.6 TNF TLR4 IL6 IL1B CXCL8 CRP
40 pneumonia 28.3 TNF TLR4 IL6 IL1B ELANE CXCL8
41 bacterial infectious disease 27.9 TNF TLR4 IL6 IL1B ELANE CXCL8
42 malaria 26.4 TNF TLR4 MMP9 IL6 IL1RN IL1B
43 asthma 26.1 TNF MMP9 IL6 IL1RN IL1R1 IL1B
44 proteasome-associated autoinflammatory syndrome 1 25.6 TNF TLR4 MMP9 IL6 IL1RN IL1R1
45 listeriosis 11.6
46 scorpion envenomation 10.7 TNF IL6
47 angioimmunoblastic lymphadenopathy with dysproteinemia 10.7 TNF IL6
48 autoimmune myocarditis 10.6 TNF IL6
49 cold agglutinin disease 10.6 IL6 CRP
50 staphylococcal toxic shock syndrome 10.6 TNF IL1B

Graphical network of the top 20 diseases related to Chorioamnionitis:



Diseases related to Chorioamnionitis

Symptoms & Phenotypes for Chorioamnionitis

MGI Mouse Phenotypes related to Chorioamnionitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.11 CRP FLT1 IL1A IL1B IL1R1 IL1RN
2 homeostasis/metabolism MP:0005376 10.07 CRP ELANE FLT1 IL1A IL1B IL1R1
3 hematopoietic system MP:0005397 10.02 ELANE FLT1 IL1A IL1B IL1R1 IL1RN
4 immune system MP:0005387 9.97 CCL2 CRP ELANE FLT1 IL1A IL1B
5 integument MP:0010771 9.61 IL1A IL1B IL1R1 IL1RN IL6 MMP9
6 neoplasm MP:0002006 9.28 ELANE IL1A IL1B IL1R1 IL6 MMP8

Drugs & Therapeutics for Chorioamnionitis

Drugs for Chorioamnionitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 161)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cefuroxime Approved Phase 4 55268-75-2 5361202 5479529
2
Cefazolin Approved Phase 4 25953-19-9 656510 33255
3
Azithromycin Approved Phase 4 83905-01-5 447043 55185
4
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
5
Misoprostol Approved Phase 4 59122-46-2 5282381
6
Progesterone Approved, Vet_approved Phase 4 57-83-0 5994
7
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
8
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
9 cefuroxime axetil Phase 4
10 Gastrointestinal Agents Phase 4
11 Antacids Phase 4
12 Oxytocics Phase 4
13 Anti-Ulcer Agents Phase 4
14 Lactoferrin Phase 4
15 Progestins Phase 4
16 Gentamicins Phase 4
17 Respiratory System Agents Phase 4
18 Clindamycin palmitate Phase 4
19 Clindamycin phosphate Phase 4
20 Hormone Antagonists Phase 4
21 Hormones Phase 4
22 glucocorticoids Phase 4
23 Anti-Inflammatory Agents Phase 4
24 Betamethasone-17,21-dipropionate Phase 4
25 Anti-Asthmatic Agents Phase 4
26 Betamethasone Valerate Phase 4 2152-44-5
27 Betamethasone sodium phosphate Phase 4
28 Betamethasone benzoate Phase 4
29 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
30
Sultamicillin Approved, Investigational Phase 2, Phase 3 76497-13-7
31
Sulbactam Approved Phase 2, Phase 3 68373-14-8
32
Oxytocin Approved, Vet_approved Phase 3 50-56-6 439302 53477758
33
Clarithromycin Approved Phase 3 81103-11-9 84029
34
Dinoprostone Approved Phase 3 363-24-6 5280360
35
Hydrocortisone acetate Approved, Vet_approved Phase 3 50-03-3
36
Hydrocortisone Approved, Vet_approved Phase 3 50-23-7 5754
37
Carbetocin Approved, Investigational Phase 3 37025-55-1 16681432 71715
38
Ampicillin Approved, Vet_approved Phase 3 69-53-4 6249
39
Erythromycin Approved, Investigational, Vet_approved Phase 3 114-07-8 441411 12560
40
Nitric Oxide Approved Phase 3 10102-43-9 145068
41
Isosorbide Dinitrate Approved, Investigational Phase 3 87-33-2 6883
42
AT-101 Approved, Investigational Phase 3 90141-22-3, 652-67-5 12597
43
Povidone Approved Phase 3 9003-39-8
44
Povidone-iodine Approved Phase 3 25655-41-8
45
Iodine Approved, Investigational Phase 3 7553-56-2 807
46
Nifedipine Approved Phase 3 21829-25-4 4485
47
Folic acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
48
Pyridoxine Approved, Investigational, Nutraceutical, Vet_approved Phase 3 65-23-6 1054
49
Calcium Approved, Nutraceutical Phase 3 7440-70-2 271
50 beta-Lactamase Inhibitors Phase 2, Phase 3

Interventional clinical trials:

(show top 50) (show all 145)
# Name Status NCT ID Phase Drugs
1 Comparison of Two Antibiotic Prophylactic Protocols in Preterm Premature Rupture of the Membranes. A Randomized Prospective, Open Trial Unknown status NCT02819570 Phase 4 I.V cefuroxime 750 mg*3/d for 2 days;I.V ampicillin 2 gram x4/d for 2 days;P.O cefuroxime 500 mgx2/d for 5 days;P.O roxithromycin 150 mg*2/d for 7 days;P.O moxypen 500 mgx3/d for 5 days
2 Increased Cefazolin (Ancef) Dosing for Prophylaxis During Cesarean Delivery in the Obese Population Completed NCT02049944 Phase 4 Cefazolin
3 Comparison of Subcuticular Suture Type in Post-Cesarean Wound Complications Completed NCT02459093 Phase 4
4 POM PROM: Pitocin or Oral Misoprostol for PROM IOL in Nulliparous Women With Unfavorable Cervical Exams Recruiting NCT04028765 Phase 4 Misoprostol;Oxytocin
5 The Effect of Maternal Antenatal Steroid Administration on the Blood Flow Through the Pulmonary Artery in the Term Fetus; a Randomized Control Double Blinded Study Recruiting NCT02978976 Phase 4 Betamethasone;saline
6 The Effect of Antibiotics on Latency in Previable Prelabor Rupture of Membranes Between 18 0/7 and 22 6/7 Weeks Gestational Age Recruiting NCT04047849 Phase 4 Antibiotics, oral Azithromycin and oral Amoxicillin
7 Lactoferrin or Progesterone for Prevention of Preterm Delivery Active, not recruiting NCT02372942 Phase 4 Lattoferrin;Progesterone
8 Foley Bulb With Oral Misoprostol Versus Oral Misoprostol for Induction of Labor: A Cluster Randomized Trial Active, not recruiting NCT03407625 Phase 4
9 Treatment Utility of Postpartum Antibiotics in Chorioamnionitis Terminated NCT01585129 Phase 4 Postpartum Antibiotics;No postpartum antibiotics
10 Removal Versus Retention of Cervical Cerclage in Preterm Premature Rupture of Membranes-A Multicenter Randomized Clinical Trial Terminated NCT00201656 Phase 4
11 Randomized Trial on Efficacy and Safety of the Antenatal Rescue Course of Glucocorticoids in Threatened Premature Birth (ACG Trial) Terminated NCT00295464 Phase 4 Betamethasone sodium phos (drug)
12 A Randomized Trial in Intrapartum Fever Of No Antibiotics for Low-risk Women (RATIONAL) Withdrawn NCT03168178 Phase 4 Standard Antibiotic Treatment
13 Antibiotic Prophylaxis in Prelabor Rupture of Membranes at Term - a Randomized Controlled Trial Completed NCT01633294 Phase 2, Phase 3 Ampicillin + gentamicin
14 Comparison of Ampicillin / Sulbactam vs. Ampicillin / Gentamicin for Treatment of Intrapartum Chorioamnionitis: a Randomized Controlled Trial Completed NCT00879190 Phase 2, Phase 3 Unasyn;Ampicillin/gentamicin
15 Randomized Phase III Trial of Cefazolin or Combination of Cefazolin and Erythromycin or Cefazolin and Clarithromycin in Women With Preterm Premature Rupture of the Membranes Completed NCT01401179 Phase 3 cefazolin, erythromycin, clarithromycin
16 The Efficacy of Symbiotic Preparation on Cytokines Which Act on Necrotising Enterocolitis Pathogenesis in Very Low Birth Weight Infants Completed NCT01899677 Phase 3 symbiotic
17 Combined Spinal and Epidural Anesthesia and Maternal Intrapartum Temperature During Vaginal Delivery: a Randomized Clinical Trial Completed NCT01078519 Phase 3 Combined epidural and spinal anesthesia
18 Early Prevention of Broncho-pulmonary Dysplasia and Neonatal Mortality in Very Preterm Infants Using Low Dose of Hydrocortisone: a Randomized Controlled Trial Completed NCT00623740 Phase 3 hydrocortisone;placebo
19 Comparison of the Efficacy of Oral Progesterone and Vaginal Progesterone After Tocolytic Therapy in Threatened Preterm Labor Completed NCT02989519 Phase 3 dydrogesterone;Micronized progesterone
20 Induction of Labor in Term Premature Rupture of Membranes: A Comparison Between Oxytocin and Dinoprostone Followed Six Hours Later by Oxytocin Completed NCT01099280 Phase 3 SYNPITAN FORT 5 IU;Propess,SYNPITAN FORT
21 Carbetocin in Preventing Postpartum Bleeding in Women With Severe Preeclampsia. Completed NCT02086994 Phase 3 misoprostol;carbetocin
22 Nitric Oxide Donor Isosorbide Mono Nitrate for Cervical Ripening in Induction of Labor in Term or Post Term Pregnancies in Females With Pre-labor Rupture of Membranes Recruiting NCT03665779 Phase 3 isosorbide mononitrate;Placebo
23 TREAT: Treatment of ppROM With Erythromycin vs. Azithromycin Trial Recruiting NCT03060473 Phase 3 Azithromycin;Erythromycin;Ampicillin;Amoxicillin
24 Tocolysis in the Management of Preterm Premature Rupture of Membranes Before 34 Weeks of Gestation: a Double-blinded Randomized Controlled Trial Not yet recruiting NCT03976063 Phase 3 Nifedipine;Placebo of Nifedipine
25 Efficacy of Prophylactic IgM-Enriched Immunoglobulin for the Management of Early-Onset Neonatal Sepsis in Very Low Birth Weight Preterm Neonates; A Randomized Controlled Trial Not yet recruiting NCT04041765 Phase 3 IgM-enriched IVIG
26 A Randomized Trial to Investigate if a Pre-operative Wash With Chlorhexidine vs Povidone-iodine Vaginal Scrub Decreases Infectious Morbidity in Patients Undergoing Cesarean Section After Ruptured Membranes Not yet recruiting NCT03925155 Phase 3 EZ scrub vaginal chlorhexidine 4% solution;10% provodine-iodine vaginal preparation
27 A Study Aimed at Comparing Two Methods of Contractions Monitoring (Electrical Uterine Monitor - EUM vs. Tocodynamometer) for Clinical Decision Making Regarding Treatment Among Pregnant Women With Preterm Contractions. Not yet recruiting NCT02875418 Phase 3
28 Study of Different Doses of Nifedipine to Treat Preterm Labor Terminated NCT00137501 Phase 3 Nifedipine
29 Can Safety Planning Improve Perinatal Outcomes Among Pregnant Women Exposed to Intimate Partner Violence? Withdrawn NCT00831831 Phase 3
30 Is More Than One Dose of Misoprostol Needed to Expedite Vaginal Delivery in a Patient With an Unripe Cervix? Unknown status NCT02680314 Phase 2 Misoprostol
31 Safety of N-acetylcysteine in Maternal Chorioamnionitis Completed NCT00724594 Phase 1, Phase 2 N-acetylcysteine;Control
32 A Randomized Controlled Trial Comparing Normal Saline With and Without Dextrose on the Course of Labor in Nulliparas Completed NCT00569439 Phase 2 D5NS;D10NS;NS
33 Effect of N-acetylcysteine in Preventing Adverse Neonatal Outcomes in Women With Intra-amniotic Infection/Inflammation Completed NCT00397735 Phase 1, Phase 2 N-acetylcysteine or placebo
34 Trial II of Lung Protection With Azithromycin in the Preterm Infant Completed NCT00319956 Phase 2 Azithromycin;Placebo
35 Concurrent Versus Sequential Administration of Amniotomy and Oxytocin for Augmentation of Labour: a Randomized Controlled Trial Completed NCT02318121 Phase 2 Oxytocin
36 Effects of Melatonin as a Novel Antioxidant and Free Radicals Scavenger in Neonatal Sepsis Completed NCT03295162 Phase 1, Phase 2 Melatonin 10 mg
37 ADDATION OF Azithromycin TO CEFAZOLIN PRE ELECTIVE C S Recruiting NCT03502356 Phase 1, Phase 2 Azithromycin
38 Randomized Controlled Trial of Mupirocin to Reduce Staphylococcus Aureus Colonization in Infants Hospitalized in a Neonatal Intensive Care Unit Recruiting NCT02967432 Phase 2 Mupirocin Topical Ointment;Petroleum Jelly
39 Randomized Control Trial of Intravenous Acetaminophen (OFIRMEV) for the Reduction of Intrapartum Maternal Fever and Fetal Tachycardia Active, not recruiting NCT02625454 Phase 2 Intravenous Acetaminophen;Oral Acetaminophen
40 Intracervical Catheters for Induction of Labour in Women With Prelabour Rupture of Membranes at Term: A Pilot Study. Terminated NCT00890630 Phase 2 Oxytocin
41 Phase 2 Study of Oral Probiotics Reduce the Incidence and Severity of Necrotizing Enterocolitis for Very Low Birth Weight Infants -Multi-Center Randomized Control Trial Terminated NCT00540033 Phase 2
42 A Randomized Trial of Foley Bulb Induction With and Without Simultaneous Use of Oxytocin Completed NCT02098421 Phase 1 Oxytocin
43 Clinical Trial: Security and Feasibility of Mesenchymal Stem Cell Therapy in Treatment and Prevention of Bronchopulmonary Dysplasia in Preterm Babies Not yet recruiting NCT02443961 Phase 1
44 Changes in Blood Flow in MCA of Fetuses to Mothers Having Clinical Chorioamnionitis During Labor Comparing to Fetuses to Healthy Mothers. Unknown status NCT00299637
45 S100B as a Marker for Fetal Brain Injury in Premature Rupture of Membranes Unknown status NCT01778725
46 Contribution of the Study of Maternal Plasmatic Regulator T Cells and Th17 for the Diagnosis of Acute Chorioanmionitis Among Women Hospitalized for Premature Rupture of Fetal Membranes (PPROM) Between 24 and 34 Gestation Weeks Unknown status NCT01610258
47 Multicenter Study on Correlation Between Premature Rupture of Membranes and Early-onset Neonatal Infections Unknown status NCT03251898
48 Treatment of Chorioamnionitis After Delivery Unknown status NCT00814905 saline;ampicillin gentamicin;Ampicillin gentamicin clindamycin;ampicillin gentamicin clindamycin
49 "Active vs Expectant Management and Routine vs Only-when-necessary Vaginal Examinations During Labour for Prelabour Rupture of Membranes at Term, a Pilot RCT Study" Unknown status NCT02872883
50 Evaluation of Intrapartum Fever in Patients Receiving Epidural Anesthesia Unknown status NCT00326521

Search NIH Clinical Center for Chorioamnionitis

Cochrane evidence based reviews: chorioamnionitis

Genetic Tests for Chorioamnionitis

Anatomical Context for Chorioamnionitis

MalaCards organs/tissues related to Chorioamnionitis:

41
Placenta, Lung, Brain, Colon, Testes, Uterus, Neutrophil

Publications for Chorioamnionitis

Articles related to Chorioamnionitis:

(show top 50) (show all 3739)
# Title Authors PMID Year
1
Labor induction with a Foley balloon inflated to 30 mL compared with 60 mL: a randomized controlled trial. 9 38
20502296 2010
2
IL-6 and TNFalpha across the umbilical circulation in term pregnancies: relationship with labour events. 9 38
20171025 2010
3
Accuracy of C-reactive protein determination in predicting chorioamnionitis and neonatal infection in pregnant women with premature rupture of membranes: a systematic review. 9 38
19819609 2009
4
Intravenous oxytocin alone for cervical ripening and induction of labour. 9 38
19821304 2009
5
The association between intrauterine inflammation and spontaneous vaginal delivery at term: a cross-sectional study. 9 38
19668329 2009
6
Using proteomics in perinatal and neonatal sepsis: hopes and challenges for the future. 9 38
19395960 2009
7
Inflammatory cytokine mRNA detection by real time PCR in chorioamniotic membranes from pregnant women with preterm premature rupture of membranes. 9 38
19272692 2009
8
Mechanisms of leukocyte accumulation and activation in chorioamnionitis: interleukin 1 beta and tumor necrosis factor alpha enhance colony stimulating factor 2 expression in term decidua. 9 38
19164476 2009
9
[Local expression of tumor necrosis factor-alpha on premature rupture of membranes]. 9 38
19669033 2009
10
Intra-amniotic LPS modulation of TLR signaling in lung and blood monocytes of fetal sheep. 9 38
19318420 2009
11
Value of amniotic fluid interleukin-8 for the prediction of histological chorioamnionitis in preterm premature rupture of membranes. 9 38
20038922 2009
12
Fetal umbilical cord blood erythropoietin, interleukin-6, pH, pO(2), pCO(2), and base excess levels in histologic and/or clinical chorioamnionitis: is the response only inflammatory? 9 38
19842878 2009
13
[Relationship among TNF-alpha gene promoter -308 site polymorphism, the levels of maternal serum TNF-alpha, and the mRNA expression placental TNF-alpha in preterm labor]. 9 38
19292050 2009
14
[The assessment of neutrophil elastase measurements usefulness in pregnant women with premature rupture of fetal membranes and chorioamnionitis suspicion]. 9 38
19323055 2009
15
Lipopolysaccharide binding protein in the early diagnosis of intraamniotic infection of pregnant women with premature rupture of the membranes. 9 38
18783308 2009
16
Uncultivated bacteria as etiologic agents of intra-amniotic inflammation leading to preterm birth. 9 38
18971361 2009
17
Severe neonatal hypoxic respiratory failure correlates with histological chorioamnionitis and raised concentrations of interleukin 6 (IL6), IL8 and C-reactive protein. 9 38
18192328 2008
18
First-trimester maternal plasma concentrations of C-reactive protein in low-risk patients and the subsequent development of chorioamnionitis. 9 38
18938289 2008
19
Haplotypes of tumor necrosis factor gene and tracheal aspirate fluid levels of tumor necrosis factor-alpha in preterm infants. 9 38
18645461 2008
20
Interleukin-6 polymorphism is associated with chorioamnionitis and neonatal infections in preterm infants. 9 38
18571528 2008
21
Nucleated red blood cells are a direct response to mediators of inflammation in newborns with early-onset neonatal sepsis. 9 38
18395034 2008
22
[Cord blood levels of interleukin 6 in preterm infants as an early marker of neonatal morbidity]. 9 38
18358131 2008
23
Using proteomic analysis of the human amniotic fluid to identify histologic chorioamnionitis. 9 38
18238979 2008
24
Increased production of beta-defensin 3 (hBD-3) by human amniotic epithelial cells (HAEC) after activation of toll-like receptor 4 in chorioamnionitis. 9 38
18345485 2008
25
Progestin-inflammatory cytokine interactions affect matrix metalloproteinase-1 and -3 expression in term decidual cells: implications for treatment of chorioamnionitis-induced preterm delivery. 9 38
17940116 2008
26
Fetal cortisol response to intrauterine microbial colonisation identified by the polymerase chain reaction and fetal inflammation. 9 38
17405871 2008
27
Use of C-reactive protein as a predictor of chorioamnionitis in preterm prelabour rupture of membranes: a systematic review. 9 38
17567416 2007
28
WITHDRAWN: Prostaglandins versus oxytocin for prelabour rupture of membranes at or near term. 9 38
17636609 2007
29
WITHDRAWN: Prostaglandins versus oxytocin for prelabour rupture of membranes at term. 9 38
17636610 2007
30
WITHDRAWN: Oxytocin for prelabour rupture of membranes at or near term. 9 38
17636608 2007
31
Maternal serum proinflammatory cytokines in preterm labor with intact membranes: neonatal outcome and histological associations. 9 38
17594943 2007
32
Perfusion with lipopolysaccharide differently affects the secretion of tumor necrosis factor-alpha and interleukin-6 by term and preterm human placenta. 9 38
17194482 2007
33
LPS induces translocation of TLR4 in amniotic epithelium. 9 38
17055575 2007
34
Maternal plasma interleukin-6, interleukin-1beta and C-reactive protein as indicators of tocolysis failure and neonatal outcome after preterm delivery. 9 38
17437242 2007
35
Toll-like receptor-2 expression in normal and pathologic human placenta. 9 38
17239937 2007
36
Impact of subclinical chorioamnionitis on maternal and neonatal outcomes. 9 38
17364282 2007
37
Delivery outcome after cold-knife conization of the uterine cervix. 9 38
16750257 2006
38
Dermatitis as a component of the fetal inflammatory response syndrome is associated with activation of Toll-like receptors in epidermal keratinocytes. 9 38
17064297 2006
39
IL-6 is constitutively expressed during lung morphogenesis and enhances fetal lung explant branching. 9 38
16988192 2006
40
Role of single nucleotide polymorphisms of cytokine genes in spontaneous preterm delivery. 9 38
17145371 2006
41
The Alabama preterm birth study: corticosteroids and neonatal outcomes in 23- to 32-week newborns with various markers of intrauterine infection. 9 38
17000235 2006
42
[Chorioamnionitis in relation to cord blood sICAM-1 and CRP levels of newborns with and without markers of early onset infection]. 9 38
17426373 2006
43
Tumor necrosis factor-alpha and interleukin-1beta regulate interleukin-8 expression in third trimester decidual cells: implications for the genesis of chorioamnionitis. 9 38
17003486 2006
44
The value of cord blood interleukin-6 levels for predicting chorioamnionitis, funisitis and neonatal infection in term premature rupture of membranes. 9 38
16459014 2006
45
Tumour necrosis factor-alpha converting enzyme in human gestational tissues from pregnancies complicated by chorioamnionitis. 9 38
16376986 2006
46
Predictors of cesarean section following elective post-dates induction of labor in nullipara with uncomplicated singleton vertex pregnancies. 9 38
16883446 2006
47
Multiplex measurement of cytokine/receptor gene polymorphisms and interaction between interleukin-10 (-1082) genotype and chorioamnionitis in extreme preterm delivery. 9 38
16814164 2006
48
Acute and chronic chorioamnionitis and the risk of perinatal human immunodeficiency virus-1 transmission. 9 38
16389028 2006
49
Amniotic fluid neutrophil elastase and lactate dehydrogenase: association with histologic chorioamnionitis. 9 38
16752257 2006
50
Intrauterine inflammation and the onset of peri-intraventricular hemorrhage in premature infants. 9 38
16549908 2006

Variations for Chorioamnionitis

Expression for Chorioamnionitis

Search GEO for disease gene expression data for Chorioamnionitis.

Pathways for Chorioamnionitis

Pathways related to Chorioamnionitis according to GeneCards Suite gene sharing:

(show top 50) (show all 83)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.04 TNF TLR4 MMP9 MMP8 IL6 IL1RN
2
Show member pathways
13.74 TNF TLR4 IL6 IL1RN IL1R1 IL1B
3
Show member pathways
13.57 TNF IL6 IL1R1 IL1B IL1A FLT1
4
Show member pathways
13.48 TNF TLR4 IL6 IL1R1 IL1B IL1A
5
Show member pathways
13.43 TNF MMP9 IL6 IL1RN IL1R1 IL1B
6
Show member pathways
13.37 TNF IL6 IL1R1 IL1B IL1A FLT1
7
Show member pathways
13.14 TNF TLR4 IL6 IL1B CXCL8 CCL2
8
Show member pathways
13.05 TNF TLR4 MMP9 IL6 IL1R1 IL1B
9
Show member pathways
12.89 TNF IL6 IL1B IL1A CXCL8
10 12.81 TNF IL1R1 IL1B IL1A FLT1
11
Show member pathways
12.81 TNF TLR4 IL6 IL1B CXCL8
12
Show member pathways
12.79 TNF TLR4 IL6 IL1R1 IL1B IL1A
13
Show member pathways
12.72 TNF TLR4 IL1R1 IL1B IL1A FLT1
14
Show member pathways
12.71 TNF TLR4 IL6 IL1R1 IL1B IL1A
15
Show member pathways
12.59 TNF IL6 IL1B CCL2
16
Show member pathways
12.59 TNF IL6 IL1B IL1A
17 12.57 TNF IL1RN IL1B CCL2
18
Show member pathways
12.47 IL1R1 IL1B IL1A FLT1
19
Show member pathways
12.45 TNF IL6 IL1B CRP CCL2
20
Show member pathways
12.43 TNF MMP9 IL6 IL1B CXCL8 CCL2
21
Show member pathways
12.41 IL1RN IL1R1 IL1B IL1A CCL2
22
Show member pathways
12.38 TNF TLR4 IL6 IL1A CXCL8
23
Show member pathways
12.38 TNF TLR4 IL6 IL1R1 IL1B IL1A
24 12.37 MMP9 IL6 FLT1 ELANE CXCL8
25
Show member pathways
12.37 TNF IL6 IL1B IL1A FLT1 CXCL8
26 12.35 TNF TLR4 IL6 IL1B IL1A
27
Show member pathways
12.32 TNF TLR4 IL1B IL1A
28
Show member pathways
12.28 TNF TLR4 IL1B IL1A
29
Show member pathways
12.28 TNF TLR4 IL6 IL1R1 IL1B CXCL8
30
Show member pathways
12.27 TLR4 MMP9 MMP8 IL1R1 IL1B IL1A
31
Show member pathways
12.27 TNF IL6 IL1RN IL1R1 IL1B IL1A
32 12.26 TNF TLR4 MMP9 IL6
33 12.26 TNF IL6 IL1RN IL1B IL1A CXCL8
34
Show member pathways
12.18 TNF TLR4 IL6 IL1R1 IL1B
35 12.17 TNF MMP9 IL1R1 IL1B IL1A CCL2
36
Show member pathways
12.16 TNF TLR4 MMP9 IL6 IL1B
37
Show member pathways
12.16 IL6 IL1R1 IL1B IL1A FLT1 CXCL8
38 12.13 TNF IL1R1 IL1B IL1A
39
Show member pathways
12.11 TLR4 IL1R1 IL1B IL1A
40 12.11 TNF MMP9 IL6 IL1B CCL2
41 12.04 IL6 IL1B IL1A CXCL8
42 12.04 TNF TLR4 IL1R1 IL1B CXCL8
43 12.03 TNF IL6 IL1R1 IL1B IL1A
44
Show member pathways
12.01 TNF MMP9 MMP8 ELANE
45 12 TNF IL6 IL1B IL1A CXCL8 CCL2
46 11.98 TNF TLR4 IL6 IL1R1 IL1B CXCL8
47 11.97 TLR4 IL6 FLT1
48 11.93 TLR4 IL6 IL1B IL1A CXCL8
49
Show member pathways
11.9 TLR4 IL6 CXCL8
50 11.88 MMP9 FLT1 CCL2

GO Terms for Chorioamnionitis

Cellular components related to Chorioamnionitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.77 TNF OXT MMP9 MMP8 IL6 IL1RN
2 extracellular region GO:0005576 9.47 TNF OXT MMP9 MMP8 IL6 IL1RN
3 secretory granule GO:0030141 9.33 OXT IL1B ELANE

Biological processes related to Chorioamnionitis according to GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.97 TNF TLR4 IL1RN IL1B
2 positive regulation of angiogenesis GO:0045766 9.95 IL1B IL1A FLT1 CXCL8
3 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.92 TNF TLR4 IL6 IL1B
4 immune response GO:0006955 9.91 TNF TLR4 IL6 IL1RN IL1R1 IL1B
5 activation of MAPK activity GO:0000187 9.9 TNF TLR4 IL1B
6 positive regulation of DNA-binding transcription factor activity GO:0051091 9.9 TNF IL6 IL1B
7 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.9 TNF TLR4 FLT1 CCL2
8 defense response to Gram-positive bacterium GO:0050830 9.89 TNF IL6 CRP
9 regulation of inflammatory response GO:0050727 9.88 TNF TLR4 IL1R1
10 cellular response to organic cyclic compound GO:0071407 9.88 TNF IL1B CCL2
11 neutrophil chemotaxis GO:0030593 9.88 IL1RN IL1B CXCL8 CCL2
12 positive regulation of MAP kinase activity GO:0043406 9.87 TNF FLT1 ELANE
13 extracellular matrix disassembly GO:0022617 9.87 MMP9 MMP8 ELANE
14 cellular response to lipopolysaccharide GO:0071222 9.87 TNF TLR4 IL6 IL1RN IL1B CXCL8
15 humoral immune response GO:0006959 9.86 TNF IL6 CCL2
16 positive regulation of smooth muscle cell proliferation GO:0048661 9.86 TNF IL6 ELANE
17 leukocyte migration GO:0050900 9.86 TNF IL1B ELANE
18 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.86 TNF TLR4 MMP8 IL1B
19 interleukin-1-mediated signaling pathway GO:0070498 9.85 IL1RN IL1R1 IL1B IL1A
20 monocyte chemotaxis GO:0002548 9.83 IL6 FLT1 CCL2
21 positive regulation of interferon-gamma production GO:0032729 9.83 TNF TLR4 IL1R1 IL1B
22 positive regulation of JNK cascade GO:0046330 9.83 TNF TLR4 MMP8 IL1RN IL1B
23 protein kinase B signaling GO:0043491 9.82 TNF IL1B CCL2
24 positive regulation of nitric oxide biosynthetic process GO:0045429 9.81 TNF TLR4 MMP8 IL1B
25 lipopolysaccharide-mediated signaling pathway GO:0031663 9.8 TNF TLR4 IL1B CCL2
26 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.79 TNF IL1B IL1A
27 positive regulation of interleukin-8 production GO:0032757 9.79 TNF TLR4 IL1B
28 negative regulation of neurogenesis GO:0050768 9.78 TNF IL6 IL1B
29 positive regulation of chemokine production GO:0032722 9.77 TNF TLR4 IL6
30 positive regulation of glial cell proliferation GO:0060252 9.75 TNF IL6 IL1B
31 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.74 TNF TLR4 ELANE
32 embryonic digestive tract development GO:0048566 9.73 TNF CXCL8
33 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.73 TNF IL1B
34 negative regulation of lipid catabolic process GO:0050995 9.73 TNF IL1B
35 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.73 TNF IL1B
36 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.72 TNF IL1B
37 negative regulation of growth of symbiont in host GO:0044130 9.72 TNF ELANE
38 positive regulation of reactive oxygen species biosynthetic process GO:1903428 9.72 TLR4 MMP8
39 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.72 TLR4 CCL2
40 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.72 IL1B IL1A
41 PERK-mediated unfolded protein response GO:0036499 9.71 CXCL8 CCL2
42 positive regulation of chemokine biosynthetic process GO:0045080 9.71 TNF IL1B
43 negative regulation of lipid storage GO:0010888 9.71 TNF IL6 CRP
44 response to glucocorticoid GO:0051384 9.71 TNF OXT IL6 IL1RN
45 regulation of establishment of endothelial barrier GO:1903140 9.7 TNF IL1B
46 positive regulation of prostaglandin secretion GO:0032308 9.7 OXT IL1B
47 ectopic germ cell programmed cell death GO:0035234 9.7 IL1B IL1A
48 regulation of neuroinflammatory response GO:0150077 9.68 MMP9 MMP8
49 positive regulation of T-helper 1 cell cytokine production GO:2000556 9.68 IL1R1 IL1B
50 positive regulation of fever generation GO:0031622 9.67 TNF IL1B

Molecular functions related to Chorioamnionitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 9.43 TNF IL1R1 ELANE
2 endopeptidase activity GO:0004175 9.33 MMP9 MMP8 ELANE
3 cytokine activity GO:0005125 9.17 TNF IL6 IL1RN IL1B IL1A CXCL8
4 interleukin-1 receptor binding GO:0005149 9.13 IL1RN IL1B IL1A

Sources for Chorioamnionitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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