MCID: CHR010
MIFTS: 37

Chorioangioma

Categories: Cancer diseases, Fetal diseases, Reproductive diseases

Aliases & Classifications for Chorioangioma

MalaCards integrated aliases for Chorioangioma:

Name: Chorioangioma 12 15 74
Placental Hemangioma 12 17

Classifications:



External Ids:

Disease Ontology 12 DOID:277
MeSH 45 D006391
NCIt 51 C4868
SNOMED-CT 69 2099007
UMLS 74 C0677608

Summaries for Chorioangioma

MalaCards based summary : Chorioangioma, also known as placental hemangioma, is related to lymphatic malformation 7 and fetal edema. An important gene associated with Chorioangioma is AFP (Alpha Fetoprotein), and among its related pathways/superpathways are Glioma and Wnt / Hedgehog / Notch. Affiliated tissues include placenta, liver and heart, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 77 Chorioangioma is a benign tumor of placenta. It is seen in approximately 0.5 to 1% pregnancies. It is... more...

Related Diseases for Chorioangioma

Diseases related to Chorioangioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Related Disease Score Top Affiliating Genes
1 lymphatic malformation 7 10.5
2 fetal edema 10.5
3 hydrops fetalis 10.5
4 polyhydramnios 10.4
5 sclerosing hepatic carcinoma 10.3 AFP PTHLH
6 liver sarcoma 10.3 AFP PTHLH
7 hydrocele 10.2 AFP PECAM1
8 ovarian solid teratoma 10.2 AFP CD34
9 malignant pineal area germ cell neoplasm 10.2 AFP CD34
10 liver lymphoma 10.2 AFP FUT4
11 liver inflammatory pseudotumor 10.2 AFP CD34
12 subclavian steal syndrome 10.2 IL24 NOTCH1
13 type 1 diabetes mellitus 11 10.2 CTLA4 NOTCH1
14 invasive malignant thymoma 10.2 CD34 PTHLH
15 testicular infarct 10.1 AFP FUT4
16 hemangioma 10.1
17 thrombocytopenia 10.1
18 rere-related disorders 10.1
19 granulomatous gastritis 10.1 FUT4 NOTCH1
20 kaposiform hemangioendothelioma 10.1 CD34 PECAM1
21 mixed germ cell cancer 10.1 AFP FUT4
22 erythema elevatum diutinum 10.1 CD34 PECAM1
23 angiomyoma 10.1 CD34 PTHLH
24 congestive heart failure 10.1
25 thrombosis 10.1
26 placental abruption 10.1
27 diffuse neonatal hemangiomatosis 10.1
28 adult xanthogranuloma 10.0 CD34 FUT4
29 hemometra 10.0 NDUFS4 OXT
30 mixed cell type cancer 10.0 AFP FUT4
31 rh isoimmunization 10.0 AFP OXT
32 aleukemic leukemia cutis 9.9 CD34 FUT4
33 sternum cancer 9.9 AFP CD34 FUT4
34 beckwith-wiedemann syndrome 9.9
35 hemangioma-thrombocytopenia syndrome 9.9
36 thanatophoric dysplasia, type i 9.9
37 preeclampsia/eclampsia 1 9.9
38 triiodothyronine receptor auxiliary protein 9.9
39 wolf-hirschhorn syndrome 9.9
40 hemolytic anemia 9.9
41 pemphigus gestationis 9.9
42 cardiac tamponade 9.9
43 portal vein thrombosis 9.9
44 graves' disease 9.9
45 periventricular leukomalacia 9.9
46 pemphigoid gestationis 9.9
47 cystic lymphangioma 9.9
48 ovarian cyst 9.9
49 placenta disease 9.9
50 chromosome 4p deletion 9.9

Graphical network of the top 20 diseases related to Chorioangioma:



Diseases related to Chorioangioma

Symptoms & Phenotypes for Chorioangioma

GenomeRNAi Phenotypes related to Chorioangioma according to GeneCards Suite gene sharing:

27 (show all 12)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-1 9.77 PECAM1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-117 9.77 AFP
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.77 NOTCH1
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-14 9.77 PECAM1
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.77 PECAM1
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-211 9.77 PECAM1
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-28 9.77 NOTCH1
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-48 9.77 AFP
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-75 9.77 AFP NOTCH1 PECAM1
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-89 9.77 AFP
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.77 PECAM1
12 Decreased telomerase activity GR00156-A 8.8 APPL1 FGFR3 MAPK14

MGI Mouse Phenotypes related to Chorioangioma:

47 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.27 AFP APPL1 CD34 CTLA4 FGFR3 IL24
2 hematopoietic system MP:0005397 10.26 APPL1 CD34 CTLA4 FGFR3 FUT4 IL24
3 cardiovascular system MP:0005385 10.24 APPL1 CTLA4 FUT4 MAPK14 NDUFS4 NOTCH1
4 cellular MP:0005384 10.22 APPL1 CD34 FGFR3 FUT4 MAPK14 NDUFS4
5 immune system MP:0005387 10.17 APPL1 CD34 CTLA4 FGFR3 FUT4 MAPK14
6 integument MP:0010771 10.06 CD34 CTLA4 FGFR3 MAPK14 NDUFS4 NOTCH1
7 endocrine/exocrine gland MP:0005379 10.04 AFP CTLA4 MAPK14 NOTCH1 OXT PIK3CG
8 mortality/aging MP:0010768 10.02 AFP APPL1 CTLA4 FGFR3 MAPK14 NDUFS4
9 digestive/alimentary MP:0005381 9.99 CTLA4 FGFR3 NOTCH1 OXT PECAM1 PTHLH
10 liver/biliary system MP:0005370 9.85 AFP CTLA4 MAPK14 NOTCH1 PECAM1 PTHLH
11 muscle MP:0005369 9.73 APPL1 MAPK14 NDUFS4 NOTCH1 PECAM1 PIK3CG
12 neoplasm MP:0002006 9.63 AFP CD34 FGFR3 MAPK14 NOTCH1 PTHLH
13 respiratory system MP:0005388 9.5 CTLA4 FGFR3 MAPK14 NDUFS4 NOTCH1 PECAM1
14 skeleton MP:0005390 9.23 CTLA4 FGFR3 MAPK14 NDUFS4 NOTCH1 PECAM1

Drugs & Therapeutics for Chorioangioma

Search Clinical Trials , NIH Clinical Center for Chorioangioma

Genetic Tests for Chorioangioma

Anatomical Context for Chorioangioma

MalaCards organs/tissues related to Chorioangioma:

42
Placenta, Liver, Heart, Fetal Liver, Pineal

Publications for Chorioangioma

Articles related to Chorioangioma:

(show top 50) (show all 178)
# Title Authors Year
1
Placental chorioangioma associated with polyhydramnios and hydrops fetalis. ( 30700468 )
2019
2
Perinatal outcome of pregnancies complicated by placental chorioangioma: a systematic review and meta-analysis. ( 31034661 )
2019
3
Call for Caution: Neonatal Portal Vein Thrombosis following Enbucrilate Embolization of Placental Chorioangioma. ( 28796996 )
2018
4
Giant chorioangioma treated with interstitial laser coagulation. ( 29072331 )
2018
5
Placental abruption after amnioreduction for polyhydramnios caused by chorioangioma. ( 29507014 )
2018
6
Coexistence of Kasabach-Merritt Syndrome and placental chorioangioma in a premature infant. ( 29991142 )
2018
7
Placental Chorioangioma with Nonimmune Hydrops Fetalis. ( 30075468 )
2018
8
Pregnancy complications and adverse outcomes in placental chorioangioma: a retrospective cohort analysis. ( 30431372 )
2018
9
Ultrasound-Guided Percutaneous Embolisation of Placental Chorioangioma Using Cyanoacrylate. ( 26727372 )
2017
10
A case of twin reversed arterial perfusion (TRAP) sequence misdiagnosed as a chorioangioma. ( 28287285 )
2017
11
Chorioangioma of Placenta: A Rare Case of Near-Miss Mortality. ( 28546672 )
2017
12
Chorioangioma of Placenta. ( 29453483 )
2017
13
Unusual complications of placental chorioangioma: consumption coagulopathy and hypertension in a preterm newborn. ( 27154993 )
2016
14
Chorioamniotic membrane separation caused by the seromucinous collection from a placental chorioangioma. ( 27200315 )
2016
15
Giant chorioangioma treated in utero via laser of feeding vessels with subsequent development of multifocal infantile hemangiomas. ( 24941233 )
2015
16
A rare giant placental chorioangioma with favorable outcome: A case report and review of the literature. ( 25043806 )
2015
17
Giant placental chorioangioma with favorable outcome: a case report and literature review of literature. ( 25944604 )
2015
18
Propranolol during pregnancy for large chorioangioma. ( 26160051 )
2015
19
Natural history and pregnancy outcome in patients with placental chorioangioma. ( 24132889 )
2014
20
Placental chorioangioma: literature review. ( 24334427 )
2014
21
Placenta chorioangioma: a rare case and systematic review of literature. ( 24460422 )
2014
22
Placental chorioangioma. ( 24612886 )
2014
23
Normal evolution of pregnancy complicated by a giant placental chorioangioma. ( 25134303 )
2014
24
Color Doppler score: a new approach for monitoring a large placental chorioangioma. ( 25295202 )
2014
25
Placental tumor (chorioangioma) as a cause of polyhydramnios: a case report. ( 25429242 )
2014
26
Fetomaternal hemorrhage with intraplacental chorioangioma. ( 22925543 )
2013
27
Rapid evolution of placental chorioangioma: natural progression and outcome. ( 23443197 )
2013
28
Prenatal three dimensional ultrasonography and expectant management of placental chorioangioma: a case report. ( 23691706 )
2013
29
Chorioangioma: an uncommon cause of hydramnios and consequent preterm labor in second trimester of pregnancy. ( 23767383 )
2013
30
Pregnancy with concomitant chorioangioma and placental mesenchymal dysplasia: a rare placental abnormality. ( 23840989 )
2013
31
Prenatal diagnosis and fetomaternal outcomes of two cases with placental chorioangioma. ( 24251055 )
2013
32
Giant placental chorioangioma with intrauterine fetal death. ( 24362665 )
2013
33
Masked anemia due to cardiac tamponade in a hydropic fetus caused by placental chorioangioma. ( 21953918 )
2012
34
Fetoscopic laser photocoagulation of feeding vessels to a large placental chorioangioma following fetal deterioration after amnioreduction. ( 22086270 )
2012
35
Combined approach in a large placental chorioangioma case with intratumoral alcohol injection, cordocentesis, IU transfusion, and amnioreduction. ( 22432544 )
2012
36
High-output cardiac failure in a fetus with thanatophoric dysplasia associated with large placental chorioangioma: case report. ( 22508320 )
2012
37
Chorioangioma of placenta: a rare placental cause for adverse fetal outcome. ( 22754703 )
2012
38
Antenatal embolization of a large placental chorioangioma: a case report. ( 22759589 )
2012
39
Prenatal management and perinatal outcome in giant placental chorioangioma complicated with hydrops fetalis, fetal anemia and maternal mirror syndrome. ( 22840187 )
2012
40
Pregnancy outcomes and ultrasonographic diagnosis in patients with histologically-proven placental chorioangioma. ( 21745690 )
2011
41
Placental chorioangioma - an unusual cause of acute polyhydramnios with an isolated rise in maternal serum ALT: a clinical marker of disease and/or risk? ( 21973147 )
2011
42
Giant placental chorioangioma: a rare cause of fetal hydrops. ( 22696752 )
2011
43
Placental chorioangioma as the cause of non-immunologic hydrops fetalis; a case report. ( 23056775 )
2011
44
Giant placental chorioangioma: natural history and pregnancy outcome. ( 19859897 )
2010
45
Antenatal embolization of a large chorioangioma by percutaneous Glubran 2 injection. ( 20737457 )
2010
46
Chorioangioma of the placenta with hydrops foetalis. ( 19534382 )
2009
47
A large chorioangioma causing intrauterine foetal demise. ( 19757713 )
2009
48
Endoscopic laser coagulation following amnioreduction for the management of a large placental chorioangioma. ( 19918962 )
2009
49
Placental chorioangioma and chorioangiosis. clinicopathological study of six unusual vascular lesions of the placenta--case reports. ( 20101866 )
2009
50
Hydrops fetalis associated with chorioangioma and thrombosis of umbilical vein. ( 20112613 )
2009

Variations for Chorioangioma

Expression for Chorioangioma

Search GEO for disease gene expression data for Chorioangioma.

Pathways for Chorioangioma

GO Terms for Chorioangioma

Cellular components related to Chorioangioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.56 AFP CD34 FGFR3 IL24 MAPK14 NOTCH1
2 cell periphery GO:0071944 8.92 CD34 FUT4 NOTCH1 PECAM1

Biological processes related to Chorioangioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 angiogenesis GO:0001525 9.46 MAPK14 NOTCH1 PECAM1 PIK3CG
2 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.43 FGFR3 IL24 PECAM1
3 response to muramyl dipeptide GO:0032495 9.32 MAPK14 NOTCH1
4 neutrophil extravasation GO:0072672 8.96 PECAM1 PIK3CG
5 glomerular endothelium development GO:0072011 8.62 CD34 PECAM1

Sources for Chorioangioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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