MCID: CHR075
MIFTS: 32

Choriocarcinoma of Ovary

Categories: Cancer diseases, Endocrine diseases, Fetal diseases, Reproductive diseases

Aliases & Classifications for Choriocarcinoma of Ovary

MalaCards integrated aliases for Choriocarcinoma of Ovary:

Name: Choriocarcinoma of Ovary 12 15 70
Ovarian Choriocarcinoma 12 17

Classifications:



External Ids:

Disease Ontology 12 DOID:5550
NCIt 50 C4515
SNOMED-CT 67 254870004
UMLS 70 C0346181

Summaries for Choriocarcinoma of Ovary

Disease Ontology : 12 A malignant ovarian germ cell neoplasm that has material basis in trophoblastic cells.

MalaCards based summary : Choriocarcinoma of Ovary, also known as ovarian choriocarcinoma, is related to gestational ovarian choriocarcinoma and non-gestational ovarian choriocarcinoma. An important gene associated with Choriocarcinoma of Ovary is CSH1 (Chorionic Somatomammotropin Hormone 1), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Relaxin signaling pathway. The drugs Palivizumab and Ribavirin have been mentioned in the context of this disorder. Affiliated tissues include ovary, bone marrow and bone.

Related Diseases for Choriocarcinoma of Ovary

Diseases related to Choriocarcinoma of Ovary via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Related Disease Score Top Affiliating Genes
1 gestational ovarian choriocarcinoma 32.2 CSH2 CSH1
2 non-gestational ovarian choriocarcinoma 32.2 CSH2 CSH1
3 choriocarcinoma 30.5 CSH2 CSH1
4 gestational choriocarcinoma 30.3 CSH2 CSH1
5 gestational trophoblastic neoplasm 29.7 CSH2 CSH1
6 non-gestational choriocarcinoma 29.4 SARNP CSH2 CSH1
7 childhood choriocarcinoma of the ovary 11.2
8 primary non-gestational choriocarcinoma of ovary 11.2
9 ectopic pregnancy 10.3
10 testicular trophoblastic tumor 10.1 CSH2 CSH1
11 choriocarcinoma of the testis 10.1 CSH2 CSH1
12 rh isoimmunization 10.1 CSH2 CSH1
13 supine hypotensive syndrome 10.1 CSH2 CSH1
14 placenta praevia 10.1 CSH2 CSH1
15 epithelioid trophoblastic tumor 10.0 CSH2 CSH1
16 rete ovarii adenoma 10.0 CSH2 CSH1
17 rete ovarii benign neoplasm 10.0 CSH2 CSH1
18 rare tumor 10.0
19 placental site trophoblastic tumor 10.0 CSH2 CSH1
20 cockayne syndrome b 10.0 CSH2 CSH1
21 trophoblastic neoplasm 10.0 CSH2 CSH1
22 teratoma 10.0
23 dysgerminoma 10.0
24 germ cells tumors 10.0
25 polyembryoma 10.0
26 persistent fetal circulation syndrome 9.9 CSH2 CSH1
27 spinal canal intradural extramedullary neoplasm 9.9 NCOA2 HEY1
28 germ cell and embryonal cancer 9.9 CSH2 CSH1
29 osteochondroma 9.9 NCOA2 HEY1
30 down syndrome 9.9
31 hydatidiform mole, recurrent, 1 9.9
32 46,xy sex reversal 1 9.9
33 adult respiratory distress syndrome 9.9
34 uveitis 9.9
35 amenorrhea 9.9
36 gonadal dysgenesis 9.9
37 46,xy sex reversal 9.9
38 endodermal sinus tumor 9.9
39 cystic teratoma 9.9
40 germ cell cancer 9.9
41 cystadenocarcinoma 9.9
42 embryonal carcinoma 9.9
43 mucinous cystadenocarcinoma 9.9
44 ovarian mucinous cystadenocarcinoma 9.9
45 ovarian cyst 9.9
46 mature teratoma 9.9
47 partial hydatidiform mole 9.9
48 placenta disease 9.8 CSH2 CSH1
49 mesenchymal chondrosarcoma 9.8 NCOA2 HEY1
50 superficial urinary bladder cancer 9.8 SARNP PFAS

Graphical network of the top 20 diseases related to Choriocarcinoma of Ovary:



Diseases related to Choriocarcinoma of Ovary

Symptoms & Phenotypes for Choriocarcinoma of Ovary

Drugs & Therapeutics for Choriocarcinoma of Ovary

Drugs for Choriocarcinoma of Ovary (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 63)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Palivizumab Approved, Investigational Phase 3 188039-54-5
2
Ribavirin Approved Phase 3 36791-04-5 37542
3
Captopril Approved Phase 3 62571-86-2 44093
4
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
5
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
6
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
7
Clotrimazole Approved, Vet_approved Phase 3 23593-75-1 2812
8
Itraconazole Approved, Investigational Phase 3 84625-61-6 55283
9
Caspofungin Approved Phase 3 179463-17-3, 162808-62-0 468682 2826718
10
Amphotericin B Approved, Investigational Phase 3 1397-89-3 14956 5280965
11 Antibodies Phase 3
12 Immunoglobulins Phase 3
13 Anti-Infective Agents Phase 3
14 Antiviral Agents Phase 3
15 Antimetabolites Phase 3
16 Antibodies, Monoclonal Phase 3
17 Immunosuppressive Agents Phase 3
18 Hormones Phase 3
19 Hormone Antagonists Phase 3
20 Immunologic Factors Phase 3
21
protease inhibitors Phase 3
22 Alkylating Agents Phase 3
23 Angiotensin-Converting Enzyme Inhibitors Phase 3
24 Antirheumatic Agents Phase 3
25 Antihypertensive Agents Phase 3
26 HIV Protease Inhibitors Phase 3
27 Cytochrome P-450 CYP3A Inhibitors Phase 3
28
Hydroxyitraconazole Phase 3 108222
29 Cytochrome P-450 Enzyme Inhibitors Phase 3
30 Antifungal Agents Phase 3
31 Amebicides Phase 3
32 Antiparasitic Agents Phase 3
33 Anti-Bacterial Agents Phase 3
34 Liposomal amphotericin B Phase 3
35 Antiprotozoal Agents Phase 3
36
Sunitinib Approved, Investigational Phase 2 557795-19-4, 341031-54-7 5329102
37
Sargramostim Approved, Investigational Phase 2 123774-72-1, 83869-56-1
38
Aldesleukin Approved Phase 2 85898-30-2, 110942-02-4
39
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
40
Ifosfamide Approved Phase 2 3778-73-2 3690
41
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
42
Oprelvekin Approved, Investigational Phase 2 145941-26-0
43
Lenograstim Approved, Investigational Phase 2 135968-09-1
44
Molgramostim Investigational Phase 2 99283-10-0
45 Angiogenesis Inhibitors Phase 2
46 Protein Kinase Inhibitors Phase 2
47 Cola Phase 1, Phase 2
48 Respiratory System Agents Phase 1, Phase 2
49 glucocorticoids Phase 1, Phase 2
50 Anti-Asthmatic Agents Phase 1, Phase 2

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 A Randomized Double-Blind Placebo-Controlled Phase III Study To Evaluate The Safety And Efficacy Of Palivizumab Combined With Aerosolized Ribavirin Compared To Ribavirin Alone To Treat RSV Pneumonia In Patients With Bone Marrow Transplants (BMT) Completed NCT00014391 Phase 3 ribavirin
2 Phase III Study of Captopril in Patients Undergoing Autologous Bone Marrow/Stem Cell Transplantation Completed NCT00004230 Phase 3 captopril;cyclophosphamide
3 A Randomized, Comparative Study of Itraconazole Versus Fluconazole for Prevention of Aspergillus Infections in Peripheral Blood Stem Cell and Marrow Transplant Recipients Completed NCT00003883 Phase 3 fluconazole;itraconazole
4 A Multicenter, Double-Blind, Randomized, Comparative Study To Evaluate The Safety, Tolerability, And Efficacy Of MK-0991 Versus (Amphotericin B) Liposome For Injection As Empirical Therapy In Patients With Persistent Fever And Neutropenia Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
5 A Strategic Study to Determine the Optimal Moment to Initiate Systemic Antifungal Therapy With Ambisome in Granulocytopenic Cancer Patients With Unexplained Fever Refractory to Empirical Antibacterials Completed NCT00003938 Phase 3 liposomal amphotericin B
6 A Phase II Study of Sunitinib in Patients With Refractory or Relapsed Germ Cell Tumors Completed NCT00453310 Phase 2 sunitinib malate
7 Oral Beclomethasone Dipropionate Capsules for Treatment of Intestinal Graft-Versus-Host Disease: Compassionate Use in Patients With Contraindictions to High-Dose Immunosuppressive Therapy Completed NCT00010283 Phase 1, Phase 2 beclomethasone dipropionate
8 Cytokine-Based Immunotherapy Following High-Dose Chemotherapy and Autologous Stem Cell Transplantation Completed NCT00003408 Phase 2
9 Donor Lymphocyte Infusion (DLI) as Adoptive Immunotherapy for Relapse Malignancies After Allogeneic Hematopoietic Transplantation Completed NCT00003887 Phase 2
10 A PHASE II STUDY OF CELLULAR ADOPTIVE IMMUNOTHERAPY AS PROPHYLAXIS FOR CYTOMEGALOVIRUS DISEASE AFTER ALLOGENEIC BONE MARROW TRANSPLANTATION Completed NCT00002673 Phase 2
11 Phase II Trial of Paclitaxel, Ifosfamide, and Cisplatin in Previously Untreated Intermediate and Poor Risk Germ Cell Tumor Patients Completed NCT00470366 Phase 2 cisplatin;ifosfamide;paclitaxel
12 Combination of Interleukin 11 (Neumega) With G-CSF to Mobilize Autologous Peripheral Blood Stem Cells (PBSC) Completed NCT00004157 Phase 2
13 A Phase I Trial of Recombinant Human Interleukin-12 After High-Dose Therapy and Autologous Hematopoietic Stem Cell Support Completed NCT00003107 Phase 1
14 A Phase I Dose Escalation Study of a 2 Day Oral Lapatinib Chemosensitization Pulse Given Prior To Weekly Intravenous Abraxane™ in Patients With Advanced Solid Tumors Completed NCT00313599 Phase 1 lapatinib;paclitaxel
15 Multi-Site Randomized Clinical Trial Comparing Standard Recovery Preparation to Extended Recovery Preparation to Enhance Long Term Function After Marrow or Stem Cell Transplant Completed NCT00049465
16 A Randomized, Placebo-Controlled, Blinded Study Of Acupuncture Therapy In Mucositis-Related Pain In Patients Undergoing Hematopoietic Stem Cell Transplantation Completed NCT00060021

Search NIH Clinical Center for Choriocarcinoma of Ovary

Genetic Tests for Choriocarcinoma of Ovary

Anatomical Context for Choriocarcinoma of Ovary

MalaCards organs/tissues related to Choriocarcinoma of Ovary:

40
Ovary, Bone Marrow, Bone

Publications for Choriocarcinoma of Ovary

Articles related to Choriocarcinoma of Ovary:

(show top 50) (show all 76)
# Title Authors PMID Year
1
A Rare Case of Non-Gestational Metastatic Ovarian Choriocarcinoma: Case Report and Literature Review With a Special Emphasis on Imaging. 61
33692915 2021
2
Rare tumors in pediatric age group: Single center experience from Saudi Arabia. 61
33708364 2021
3
Spontaneous ovarian choriocarcinoma in a young ICR mouse. 61
33627954 2021
4
Management of ovarian masses in pregnancy: patient selection for interventional treatment. 61
33172924 2020
5
Imaging in gynecological disease: clinical and ultrasound characteristics of ovarian embryonal carcinomas, non-gestational choriocarcinomas and malignant mixed germ cell tumors. 61
33142349 2020
6
Successful management of nongestational ovarian choriocarcinoma complicated with choriocarcinoma syndrome: A case report and a literature review. 61
31987522 2020
7
Clinicopathological factors and prognosis analysis of 39 cases of non-gestational ovarian choriocarcinoma. 61
32185550 2020
8
Adolescent non-gestational ovarian choriocarcinoma: report of a case and review of literature. 61
31933999 2019
9
Clinical and ultrasound features of non-gestational ovarian choriocarcinoma. 61
29080278 2018
10
A positive urine pregnancy test (UPT) with adnexal mass; ectopic pregnancy is not the ultimate diagnosis. 61
29558344 2018
11
Extremely Rare Case of Bilateral Pure Primary Non-Gestational Ovarian Choriocarcinoma. 61
29657619 2017
12
Pure non-gestational choriocarcinoma arising in the ovary. 61
29894083 2016
13
Management of bilateral malignant ovarian germ cell tumors: Experience of a single institute. 61
27446585 2016
14
Clinicopathological analysis of non-gestational ovarian choriocarcinoma: Report of two cases and review of the literature. 61
27073524 2016
15
A pure non-gestational ovarian choriocarcinoma with delayed solitary brain metastases: Case report and review of the literature. 61
26752905 2015
16
Immunohistological Description of Nongestational Ovarian Choriocarcinoma in Two Female Mice With Conditional Loss of Trp53 Driven by the Tie2 Promoter. 61
25253064 2015
17
Intra-operative cytodiagnosis of primary ovarian choriocarcinoma with Ki67 immunoexpression. 61
26229256 2015
18
Fallopian tube choriocarcinoma presenting as ovarian tumour: a case report. 61
25738040 2015
19
Pure Choriocarcinoma of the Ovary in Silver-Russell Syndrome. 61
26101195 2015
20
Primary ovarian choriocarcinoma mimicking ectopic pregnancy. 61
25105109 2014
21
The encouraging prognosis of nongestational ovarian choriocarcinoma with lung metastases. 61
24937961 2014
22
Management and outcome of ovarian malignancy complicating pregnancy: an analysis of 41 cases and review of the literature. 61
23150218 2013
23
Pure nongestational choriocarcinoma of the ovary: a case report. 61
23320455 2013
24
[Clinical analysis of 15 cases of malignant ovarian germ cell tumors with lung metastasis]. 61
22455692 2012
25
Pure non-gestational ovarian choriocarcinoma in a 45,XO/46,XX SRY-negative true hermaphrodite. 61
22070612 2011
26
Pure choriocarcinoma of the ovary: a case report. 61
21860741 2011
27
Primary ovarian choriocarcinoma presenting with acute abdomen mimicking an ectopic pregnancy. 61
21941968 2011
28
Ovarian choriocarcinoma as the first manifestation of 46,XY pure gonadal dysgenesis. 61
21102350 2011
29
Management of non-gestational ovarian choriocarcinoma: laparoscopy can be essential. Report of two cases. 61
20561742 2010
30
Clinical analysis of 21 cases of nongestational ovarian choriocarcinoma. 61
20134273 2010
31
Pure primary non-gestational ovarian choriocarcinoma: a diagnostic dilemma. 61
20090265 2010
32
Pure ovarian choriocarcinoma: report of two cases. 61
21772904 2009
33
A case of non-gestational choriocarcinoma arising in the ovary of a postmenopausal woman. 61
19809555 2009
34
Pure choriocarcinoma of ovary diagnosed by fine needle aspiration cytology. 61
19679980 2009
35
A pure nongestational ovarian choriocarcinoma in a 10-year-old girl: case report and literature review. 61
19527404 2009
36
Primary ovarian choriocarcinoma mimicking ectopic pregnancy managed with laparoscopy -- case report. 61
18459557 2008
37
Primary extrauterine ovarian choriocarcinoma mistaken for ectopic pregnancy: sonographic imaging findings. 61
17954626 2007
38
Could ovarian choriocarcinoma be detected by maternal serum screening for Down syndrome? 61
17533625 2007
39
Pure non-gestational choriocarcinoma of the ovary diagnosed by DNA polymorphism analysis. 61
16984618 2006
40
Ovarian nongestational choriocarcinoma mixed with various epithelial malignancies in association with endometriosis. 61
16527336 2006
41
Ovarian choriocarcinoma masquerading as ectopic pregnancy. 61
16753708 2006
42
Ovarian choriocarcinoma in a rhesus monkey associated with elevated serum chorionic gonadotropin levels. 61
15753479 2005
43
Pure nongestational choriocarcinoma of ovary. 61
14991382 2005
44
Imaging of pure primary ovarian choriocarcinoma. 61
15150023 2004
45
Pure ovarian choriocarcinoma: a difficult diagnosis of an unusual tumor presenting with acute abdomen in a 13-year-old girl. 61
15059168 2004
46
Primary pure ovarian choriocarcinoma mimicking ectopic pregnancy: a report of fulminant progression. 61
15143987 2004
47
Ovarian choriocarcinoma arising from partial mole as evidenced by deoxyribonucleic acid microsatellite analysis. 61
14672475 2003
48
[Anaphylaxia induced by etoposide--a case report]. 61
12938279 2003
49
[Ovarian choriocarcinoma: about one case]. 61
12865193 2003
50
Co-existent ovarian mucinous cystadenocarcinoma and ovarian choriocarcinoma. 61
12192487 2002

Variations for Choriocarcinoma of Ovary

Expression for Choriocarcinoma of Ovary

Search GEO for disease gene expression data for Choriocarcinoma of Ovary.

Pathways for Choriocarcinoma of Ovary

Pathways related to Choriocarcinoma of Ovary according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.97 HEY1 CSH2 CSH1
2
Show member pathways
11.39 NCOA2 CSH2 CSH1

GO Terms for Choriocarcinoma of Ovary

Biological processes related to Choriocarcinoma of Ovary according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to nutrient levels GO:0031667 9.37 CSH2 CSH1
2 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.32 CSH2 CSH1
3 positive regulation of JAK-STAT cascade GO:0046427 9.26 CSH2 CSH1
4 animal organ development GO:0048513 9.16 CSH2 CSH1
5 growth hormone receptor signaling pathway GO:0060396 8.96 CSH2 CSH1
6 positive regulation of growth GO:0045927 8.62 CSH2 CSH1

Molecular functions related to Choriocarcinoma of Ovary according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.16 CSH2 CSH1
2 hormone activity GO:0005179 8.96 CSH2 CSH1
3 growth hormone receptor binding GO:0005131 8.62 CSH2 CSH1

Sources for Choriocarcinoma of Ovary

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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