MCID: CHR075
MIFTS: 34

Choriocarcinoma of Ovary

Categories: Endocrine diseases, Reproductive diseases, Cancer diseases, Fetal diseases

Aliases & Classifications for Choriocarcinoma of Ovary

MalaCards integrated aliases for Choriocarcinoma of Ovary:

Name: Choriocarcinoma of Ovary 12 15 73
Ovarian Choriocarcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5550
NCIt 50 C4515
SNOMED-CT 68 254870004
UMLS 73 C0346181

Summaries for Choriocarcinoma of Ovary

MalaCards based summary : Choriocarcinoma of Ovary, also known as ovarian choriocarcinoma, is related to non-gestational ovarian choriocarcinoma and non-gestational choriocarcinoma. An important gene associated with Choriocarcinoma of Ovary is TEK (TEK Receptor Tyrosine Kinase), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Regulation of IFNA signaling. The drugs Cisplatin and Ribavirin have been mentioned in the context of this disorder. Affiliated tissues include ovary, bone marrow and bone.

Related Diseases for Choriocarcinoma of Ovary

Diseases related to Choriocarcinoma of Ovary via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Related Disease Score Top Affiliating Genes
1 non-gestational ovarian choriocarcinoma 32.1 NCAM1 PRL SRY TEK
2 non-gestational choriocarcinoma 29.4 CSH1 CSH2
3 choriocarcinoma 29.1 CSH1 CSH2
4 gestational ovarian choriocarcinoma 12.2
5 primary non-gestational choriocarcinoma of ovary 12.1
6 childhood choriocarcinoma of the ovary 11.1
7 ovarian primitive germ cell tumor 10.5 SRY TEK
8 cardiovascular organ benign neoplasm 10.4 ENO2 TEK
9 benign perivascular tumor 10.4 ENO2 TEK
10 glomangioma 10.3 ENO2 TEK
11 multiple mucosal neuroma 10.3 ENO2 NCAM1
12 lung meningioma 10.3 ENO2 NCAM1
13 sensory organ benign neoplasm 10.3 ENO2 NCAM1
14 gallbladder small cell carcinoma 10.3 ENO2 NCAM1
15 cutaneous ganglioneuroma 10.3 ENO2 NCAM1
16 extrahepatic bile duct adenocarcinoma 10.3 ENO2 NCAM1
17 orbital cancer 10.3 ENO2 NCAM1
18 cystadenofibroma 10.3 NCAM1 SRY
19 endometrial small cell carcinoma 10.3 ENO2 NCAM1
20 angiomyoma 10.3 ENO2 NCAM1
21 gastric squamous cell carcinoma 10.3 ENO2 NCAM1
22 gastric small cell carcinoma 10.3 ENO2 NCAM1
23 subependymoma 10.3 ENO2 NCAM1
24 cervical clear cell adenocarcinoma 10.3 ENO2 NCAM1
25 rete testis neoplasm 10.2 ENO2 NCAM1
26 cervix small cell carcinoma 10.2 ENO2 NCAM1
27 large cell neuroendocrine carcinoma 10.2 ENO2 NCAM1
28 mixed ductal-endocrine carcinoma 10.2 ENO2 NCAM1
29 head injury 10.2 ENO2 PRL
30 sex differentiation disease 10.2 PRL SRY
31 ganglioneuroma 10.2 ENO2 NCAM1
32 lung benign neoplasm 10.1 ENO2 NCAM1
33 granulosa cell tumor of the ovary 10.1 ENO2 PRL
34 small cell carcinoma 10.1 ENO2 NCAM1
35 gynecomastia 10.0 PRL SRY
36 peripheral nervous system neoplasm 10.0 ENO2 NCAM1
37 autonomic nervous system neoplasm 10.0 ENO2 NCAM1
38 large cell carcinoma 10.0 ENO2 NCAM1
39 organ system benign neoplasm 10.0 ENO2 PRL
40 merkel cell carcinoma 9.9 ENO2 NCAM1
41 amenorrhea 9.9 PRL SRY
42 testicular trophoblastic tumor 9.9 CSH1 CSH2
43 testicular granulosa cell tumor 9.9 CSH1 CSH2
44 juvenile type testicular granulosa cell tumor 9.9 CSH1 CSH2
45 choriocarcinoma of the testis 9.8 CSH1 CSH2
46 gestational trophoblastic neoplasm 9.8 CSH1 CSH2
47 reproductive system disease 9.8 PRL SRY
48 rh isoimmunization 9.8 CSH1 CSH2
49 gestational choriocarcinoma 9.8
50 chronic salpingitis 9.8 CSH1 CSH2

Graphical network of the top 20 diseases related to Choriocarcinoma of Ovary:



Diseases related to Choriocarcinoma of Ovary

Symptoms & Phenotypes for Choriocarcinoma of Ovary

Drugs & Therapeutics for Choriocarcinoma of Ovary

Drugs for Choriocarcinoma of Ovary (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 74)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 3,Phase 2 15663-27-1 84093 441203 2767
2
Ribavirin Approved Phase 3 36791-04-5 37542
3
Carboplatin Approved Phase 3,Phase 2 41575-94-4 10339178 498142 38904
4
Captopril Approved Phase 3 62571-86-2 44093
5
Amphotericin B Approved, Investigational Phase 3 1397-89-3 14956 5280965
6
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
7
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
8
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
9
Itraconazole Approved, Investigational Phase 3 84625-61-6 55283
10
Palivizumab Approved, Investigational Phase 3 188039-54-5
11
Caspofungin Approved Phase 3 179463-17-3, 162808-62-0 468682 2826718
12
Etoposide Approved Phase 3 33419-42-0 36462
13
Bleomycin Approved, Investigational Phase 3 11056-06-7 5360373
14
Hydroxyitraconazole Phase 3
15 Alkylating Agents Phase 3,Phase 2
16
protease inhibitors Phase 3
17 Steroid Synthesis Inhibitors Phase 3
18 Cytochrome P-450 CYP2C9 Inhibitors Phase 3
19 Cytochrome P-450 CYP3A Inhibitors Phase 3
20 HIV Protease Inhibitors Phase 3
21 Cytochrome P-450 Enzyme Inhibitors Phase 3
22 Hormone Antagonists Phase 3,Phase 1,Phase 2
23 Hormones Phase 3,Phase 1,Phase 2
24 Angiotensin-Converting Enzyme Inhibitors Phase 3
25 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 1,Phase 2
26 Echinocandins Phase 3
27 Anti-Bacterial Agents Phase 3
28 Antibodies Phase 3,Phase 1
29 Immunoglobulins Phase 3,Phase 1
30 Antibodies, Monoclonal Phase 3,Phase 1
31 Antihypertensive Agents Phase 3
32 Immunosuppressive Agents Phase 3,Phase 1,Phase 2
33 Anti-Infective Agents Phase 3,Phase 2
34 Antifungal Agents Phase 3
35 Antiparasitic Agents Phase 3
36 Antiprotozoal Agents Phase 3
37 Liposomal amphotericin B Phase 3
38 Antirheumatic Agents Phase 3
39 Antimetabolites Phase 3
40 Antiviral Agents Phase 3,Phase 2
41 Antimitotic Agents Phase 3,Phase 2,Phase 1
42 Antineoplastic Agents, Alkylating Phase 3,Phase 2
43 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Phase 1
44 Podophyllotoxin Phase 3 518-28-5
45 Topoisomerase Inhibitors Phase 3
46 Dermatologic Agents Phase 3
47 Antibiotics, Antitubercular Phase 3
48 Etoposide phosphate Phase 3
49 Keratolytic Agents Phase 3
50
Lenograstim Approved, Investigational Phase 2 135968-09-1

Interventional clinical trials:

(show all 21)
# Name Status NCT ID Phase Drugs
1 Captopril in Treating Patients Undergoing Bone Marrow or Stem Cell Transplantation Completed NCT00004230 Phase 3 captopril;cyclophosphamide
2 Ribavirin With or Without Monoclonal Antibody Therapy in Treating Patients Who Develop RSV Pneumonia Following Peripheral Stem Cell Transplantation Completed NCT00014391 Phase 3 ribavirin
3 Itraconazole Compared With Fluconazole to Prevent Infections in Patients Undergoing Peripheral Stem Cell or Bone Marrow Transplantation Completed NCT00003883 Phase 3 fluconazole;itraconazole
4 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
5 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3 liposomal amphotericin B
6 Active Surveillance, Bleomycin, Carboplatin, Etoposide, or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors Recruiting NCT03067181 Phase 3 Bleomycin;Carboplatin;Cisplatin;Etoposide
7 Combination Chemotherapy in Treating Young Patients With Recurrent or Resistant Malignant Germ Cell Tumors Completed NCT00467051 Phase 2 paclitaxel;carboplatin;ifosfamide
8 Sunitinib in Treating Patients With Metastatic Germ Cell Tumors That Have Relapsed or Not Responded to Treatment Completed NCT00453310 Phase 2 sunitinib malate
9 Combination Chemotherapy and Pegfilgrastim in Treating Patients With Previously Untreated Germ Cell Tumors Completed NCT00470366 Phase 2 cisplatin;ifosfamide;paclitaxel
10 Immunotherapy in Treating Patients Who Are Undergoing Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00002673 Phase 2
11 Lymphocyte Infusion in Treating Patients With Relapsed Cancer After Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00003887 Phase 2
12 Beclomethasone in Treating Patients With Graft-Versus-Host Disease of the Esophagus, Stomach, Small Intestine, or Colon Completed NCT00010283 Phase 1, Phase 2 beclomethasone dipropionate
13 Interleukin-11 Plus Filgrastim Prior to Peripheral Stem Cell Transplantation in Patients With Non-Hodgkin's Lymphoma, Hodgkin's Disease, Breast Cancer, or Other Solid Tumors Completed NCT00004157 Phase 2
14 Biological Therapy Following Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Cancer Completed NCT00003408 Phase 2
15 Ipilimumab After Allogeneic Stem Cell Transplant in Treating Patients With Persistent or Progressive Cancer Completed NCT00060372 Phase 1 ipilimumab;therapeutic allogeneic lymphocytes
16 Lapatinib and Paclitaxel in Treating Patients With Advanced Solid Tumors Completed NCT00313599 Phase 1 lapatinib;paclitaxel
17 Interleukin-12 in Treating Patients With Hematologic Cancers or Solid Tumors Completed NCT00003107 Phase 1
18 Changes in Brain Function in Patients With Stage I, Stage II, Stage III, or Stage IV Ovarian, Primary Peritoneal, or Fallopian Tube Cancer Who Are Receiving Chemotherapy Completed NCT01080521
19 Acupuncture in Treating Mucositis-Related Pain Caused by Chemotherapy in Patients Undergoing Stem Cell Transplantation Completed NCT00060021 Not Applicable
20 Standard Follow-up Compared With Extended Follow-up in Treating Patients Who Have Undergone Stem Cell Transplantation for Cancer Completed NCT00049465 Not Applicable
21 DNA Analysis in Samples From Younger Patients With Germ Cell Tumors and Their Parents or Siblings Recruiting NCT01434355

Search NIH Clinical Center for Choriocarcinoma of Ovary

Genetic Tests for Choriocarcinoma of Ovary

Anatomical Context for Choriocarcinoma of Ovary

MalaCards organs/tissues related to Choriocarcinoma of Ovary:

41
Ovary, Bone Marrow, Bone, Breast, Brain, Colon, Small Intestine

Publications for Choriocarcinoma of Ovary

Articles related to Choriocarcinoma of Ovary:

# Title Authors Year
1
Pure choriocarcinoma of ovary diagnosed by fine needle aspiration cytology. ( 19679980 )
2009
2
Pure nongestational choriocarcinoma of ovary. ( 14991382 )
2005
3
Pure non-gestational choriocarcinoma of ovary a case report with autopsy findings. ( 12035382 )
2001
4
Pure choriocarcinoma of ovary, probably non-gestational in origin. ( 7781102 )
1995

Variations for Choriocarcinoma of Ovary

Expression for Choriocarcinoma of Ovary

Search GEO for disease gene expression data for Choriocarcinoma of Ovary.

Pathways for Choriocarcinoma of Ovary

GO Terms for Choriocarcinoma of Ovary

Cellular components related to Choriocarcinoma of Ovary according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.35 CSH1 CSH2 NCAM1 PRL TEK
2 endosome lumen GO:0031904 8.62 CSH1 PRL

Biological processes related to Choriocarcinoma of Ovary according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of angiogenesis GO:0016525 9.16 PRL TEK
2 regulation of signaling receptor activity GO:0010469 9.13 CSH1 CSH2 PRL
3 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 8.62 CSH1 PRL

Molecular functions related to Choriocarcinoma of Ovary according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Ras guanyl-nucleotide exchange factor activity GO:0005088 8.96 NCAM1 TEK
2 hormone activity GO:0005179 8.8 CSH1 CSH2 PRL

Sources for Choriocarcinoma of Ovary

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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