MCID: CHR075
MIFTS: 37

Choriocarcinoma of Ovary

Categories: Cancer diseases, Endocrine diseases, Fetal diseases, Reproductive diseases

Aliases & Classifications for Choriocarcinoma of Ovary

MalaCards integrated aliases for Choriocarcinoma of Ovary:

Name: Choriocarcinoma of Ovary 12 15 74
Ovarian Choriocarcinoma 12 17

Classifications:



External Ids:

Disease Ontology 12 DOID:5550
NCIt 51 C4515
UMLS 74 C0346181

Summaries for Choriocarcinoma of Ovary

Disease Ontology : 12 A malignant ovarian germ cell neoplasm that has material basis in trophoblastic cells.

MalaCards based summary : Choriocarcinoma of Ovary, also known as ovarian choriocarcinoma, is related to non-gestational ovarian choriocarcinoma and choriocarcinoma. An important gene associated with Choriocarcinoma of Ovary is TEK (TEK Receptor Tyrosine Kinase), and among its related pathways/superpathways are Cytokine Signaling in Immune system and PI3K-Akt signaling pathway. The drugs Cyclophosphamide and Captopril have been mentioned in the context of this disorder. Affiliated tissues include ovary, bone and bone marrow.

Related Diseases for Choriocarcinoma of Ovary

Diseases related to Choriocarcinoma of Ovary via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Related Disease Score Top Affiliating Genes
1 non-gestational ovarian choriocarcinoma 33.3 NCAM1 PRL TEK
2 choriocarcinoma 30.2 CSH1 CSH2
3 non-gestational choriocarcinoma 29.7 CSH1 CSH2
4 gestational ovarian choriocarcinoma 12.4
5 primary non-gestational choriocarcinoma of ovary 12.3
6 childhood choriocarcinoma of the ovary 11.3
7 ectopic pregnancy 10.3
8 multiple mucosal neuroma 10.1 ENO2 NCAM1
9 lung meningioma 10.1 ENO2 NCAM1
10 cutaneous ganglioneuroma 10.1 ENO2 NCAM1
11 ganglioneuroma 10.1 ENO2 NCAM1
12 extrahepatic bile duct adenocarcinoma 10.1 ENO2 NCAM1
13 granulosa cell tumor of the ovary 10.1 ENO2 PRL
14 orbital cancer 10.1 ENO2 NCAM1
15 gallbladder small cell carcinoma 10.1 ENO2 NCAM1
16 small cell carcinoma 10.1 ENO2 NCAM1
17 endometrial small cell carcinoma 10.1 ENO2 NCAM1
18 middle cerebral artery infarction 10.1 ENO2 NCAM1
19 angiomyoma 10.0 ENO2 NCAM1
20 cervical clear cell adenocarcinoma 10.0 ENO2 NCAM1
21 teratoma 10.0
22 gastric small cell carcinoma 10.0 ENO2 NCAM1
23 subependymoma 10.0 ENO2 NCAM1
24 gastric squamous cell carcinoma 10.0 ENO2 NCAM1
25 rete testis neoplasm 10.0 ENO2 NCAM1
26 cervix small cell carcinoma 10.0 ENO2 NCAM1
27 cranial nerve malignant neoplasm 10.0 ENO2 NCAM1
28 large cell neuroendocrine carcinoma 10.0 ENO2 NCAM1
29 mixed ductal-endocrine carcinoma 10.0 ENO2 NCAM1
30 ileum cancer 10.0 ENO2 NCAM1
31 hemangioma 10.0 ENO2 TEK
32 lung benign neoplasm 10.0 ENO2 NCAM1
33 autonomic nervous system neoplasm 10.0 ENO2 NCAM1
34 peripheral nervous system neoplasm 10.0 ENO2 NCAM1
35 large cell carcinoma 9.9 ENO2 NCAM1
36 testicular trophoblastic tumor 9.9 CSH1 CSH2
37 gestational choriocarcinoma 9.9
38 merkel cell carcinoma 9.9 ENO2 NCAM1
39 choriocarcinoma of the testis 9.9 CSH1 CSH2
40 down syndrome 9.9
41 gonadal dysgenesis 9.9
42 cystadenocarcinoma 9.9
43 mucinous cystadenocarcinoma 9.9
44 ovarian mucinous cystadenocarcinoma 9.9
45 neuroendocrine tumor 9.9 ENO2 NCAM1
46 gestational trophoblastic neoplasm 9.9 CSH1 CSH2
47 chronic salpingitis 9.9 CSH1 CSH2
48 rh isoimmunization 9.9 CSH1 CSH2
49 small cell cancer of the lung 9.8 ENO2 NCAM1
50 placenta disease 9.8 CSH1 CSH2

Graphical network of the top 20 diseases related to Choriocarcinoma of Ovary:



Diseases related to Choriocarcinoma of Ovary

Symptoms & Phenotypes for Choriocarcinoma of Ovary

Drugs & Therapeutics for Choriocarcinoma of Ovary

Drugs for Choriocarcinoma of Ovary (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 78)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyclophosphamide Approved, Investigational Phase 3,Phase 2 6055-19-2, 50-18-0 2907
2
Captopril Approved Phase 3 62571-86-2 44093
3
Ribavirin Approved Phase 3 36791-04-5 37542
4
Palivizumab Approved, Investigational Phase 3 188039-54-5
5
Itraconazole Approved, Investigational Phase 3 84625-61-6 55283
6
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
7
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
8
Caspofungin Approved Phase 3 179463-17-3, 162808-62-0 2826718 468682
9
Amphotericin B Approved, Investigational Phase 3 1397-89-3 14956 5280965
10
Carboplatin Approved Phase 3,Phase 2 41575-94-4 38904 10339178 498142
11
Cisplatin Approved Phase 3,Phase 2 15663-27-1 441203 84093 2767
12
Etoposide Approved Phase 3 33419-42-0 36462
13
Bleomycin Approved, Investigational Phase 3 11056-06-7 5360373
14 HIV Protease Inhibitors Phase 3
15 Antineoplastic Agents, Alkylating Phase 3,Phase 2
16 Immunosuppressive Agents Phase 3,Phase 1,Phase 2
17 Antirheumatic Agents Phase 3
18 Alkylating Agents Phase 3,Phase 2
19 Antihypertensive Agents Phase 3
20 Immunologic Factors Phase 3,Phase 2,Phase 1
21 Angiotensin-Converting Enzyme Inhibitors Phase 3
22
protease inhibitors Phase 3
23 Antibodies, Monoclonal Phase 3,Phase 1
24 Antibodies Phase 3,Phase 1
25 Immunoglobulins Phase 3,Phase 1
26 Antiviral Agents Phase 3,Phase 2
27 Anti-Infective Agents Phase 3,Phase 2
28 Antimetabolites Phase 3
29 Cytochrome P-450 CYP3A Inhibitors Phase 3
30 Cytochrome P-450 CYP2C19 Inhibitors Phase 3
31 Hormone Antagonists Phase 3,Phase 1,Phase 2
32 Cytochrome P-450 Enzyme Inhibitors Phase 3
33 Cytochrome P-450 CYP2C9 Inhibitors Phase 3
34 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 1,Phase 2
35 Steroid Synthesis Inhibitors Phase 3
36 Hormones Phase 3,Phase 1,Phase 2
37
Hydroxyitraconazole Phase 3
38 Antifungal Agents Phase 3
39 Liposomal amphotericin B Phase 3
40 Anti-Bacterial Agents Phase 3
41 Antiprotozoal Agents Phase 3
42 Antiparasitic Agents Phase 3
43 Antimitotic Agents Phase 3,Phase 2,Phase 1
44 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Phase 1
45 Etoposide phosphate Phase 3
46 Antibiotics, Antitubercular Phase 3
47 Topoisomerase Inhibitors Phase 3
48 Podophyllotoxin Phase 3 518-28-5
49 Dermatologic Agents Phase 3
50 Keratolytic Agents Phase 3

Interventional clinical trials:

(show all 21)
# Name Status NCT ID Phase Drugs
1 Captopril in Treating Patients Undergoing Bone Marrow or Stem Cell Transplantation Completed NCT00004230 Phase 3 captopril;cyclophosphamide
2 Ribavirin With or Without Monoclonal Antibody Therapy in Treating Patients Who Develop RSV Pneumonia Following Peripheral Stem Cell Transplantation Completed NCT00014391 Phase 3 ribavirin
3 Itraconazole Compared With Fluconazole to Prevent Infections in Patients Undergoing Peripheral Stem Cell or Bone Marrow Transplantation Completed NCT00003883 Phase 3 fluconazole;itraconazole
4 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
5 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3 liposomal amphotericin B
6 Active Surveillance, Bleomycin, Carboplatin, Etoposide, or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors Recruiting NCT03067181 Phase 3 Bleomycin;Carboplatin;Cisplatin;Etoposide;Etoposide Phosphate
7 Combination Chemotherapy in Treating Young Patients With Recurrent or Resistant Malignant Germ Cell Tumors Completed NCT00467051 Phase 2 Carboplatin;Ifosfamide;Paclitaxel
8 Sunitinib in Treating Patients With Metastatic Germ Cell Tumors That Have Relapsed or Not Responded to Treatment Completed NCT00453310 Phase 2 sunitinib malate
9 Combination Chemotherapy and Pegfilgrastim in Treating Patients With Previously Untreated Germ Cell Tumors Completed NCT00470366 Phase 2 cisplatin;ifosfamide;paclitaxel
10 Immunotherapy in Treating Patients Who Are Undergoing Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00002673 Phase 2
11 Lymphocyte Infusion in Treating Patients With Relapsed Cancer After Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00003887 Phase 2
12 Beclomethasone in Treating Patients With Graft-Versus-Host Disease of the Esophagus, Stomach, Small Intestine, or Colon Completed NCT00010283 Phase 1, Phase 2 beclomethasone dipropionate
13 Interleukin-11 Plus Filgrastim Prior to Peripheral Stem Cell Transplantation in Patients With Non-Hodgkin's Lymphoma, Hodgkin's Disease, Breast Cancer, or Other Solid Tumors Completed NCT00004157 Phase 2
14 Biological Therapy Following Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Cancer Completed NCT00003408 Phase 2
15 Ipilimumab After Allogeneic Stem Cell Transplant in Treating Patients With Persistent or Progressive Cancer Completed NCT00060372 Phase 1 ipilimumab;therapeutic allogeneic lymphocytes
16 Lapatinib and Paclitaxel in Treating Patients With Advanced Solid Tumors Completed NCT00313599 Phase 1 lapatinib;paclitaxel
17 Interleukin-12 in Treating Patients With Hematologic Cancers or Solid Tumors Completed NCT00003107 Phase 1
18 DNA Analysis in Samples From Younger Patients With Germ Cell Tumors and Their Parents or Siblings Completed NCT01434355
19 Changes in Brain Function in Patients With Stage I, Stage II, Stage III, or Stage IV Ovarian, Primary Peritoneal, or Fallopian Tube Cancer Who Are Receiving Chemotherapy Completed NCT01080521
20 Acupuncture in Treating Mucositis-Related Pain Caused by Chemotherapy in Patients Undergoing Stem Cell Transplantation Completed NCT00060021 Not Applicable
21 Standard Follow-up Compared With Extended Follow-up in Treating Patients Who Have Undergone Stem Cell Transplantation for Cancer Completed NCT00049465 Not Applicable

Search NIH Clinical Center for Choriocarcinoma of Ovary

Genetic Tests for Choriocarcinoma of Ovary

Anatomical Context for Choriocarcinoma of Ovary

MalaCards organs/tissues related to Choriocarcinoma of Ovary:

42
Ovary, Bone, Bone Marrow, Brain, Colon, Breast, Small Intestine

Publications for Choriocarcinoma of Ovary

Articles related to Choriocarcinoma of Ovary:

(show all 17)
# Title Authors Year
1
The encouraging prognosis of nongestational ovarian choriocarcinoma with lung metastases. ( 24937961 )
2014
2
Pure choriocarcinoma of ovary diagnosed by fine needle aspiration cytology. ( 19679980 )
2009
3
Pure nongestational choriocarcinoma of ovary. ( 14991382 )
2005
4
Pure ovarian choriocarcinoma: a difficult diagnosis of an unusual tumor presenting with acute abdomen in a 13-year-old girl. ( 15059168 )
2004
5
Primary pure ovarian choriocarcinoma mimicking ectopic pregnancy: a report of fulminant progression. ( 15143987 )
2004
6
Imaging of pure primary ovarian choriocarcinoma. ( 15150023 )
2004
7
Ovarian choriocarcinoma arising from partial mole as evidenced by deoxyribonucleic acid microsatellite analysis. ( 14672475 )
2003
8
Pure non-gestational choriocarcinoma of ovary a case report with autopsy findings. ( 12035382 )
2001
9
Nongestational pure ovarian choriocarcinoma with contralateral teratoma. ( 11161870 )
2001
10
Salvage liver surgery of a chemorefractory ovarian choriocarcinoma. ( 9103412 )
1997
11
Pure choriocarcinoma of ovary, probably non-gestational in origin. ( 7781102 )
1995
12
Spontaneous ovarian choriocarcinoma, yolk sac carcinoma, and teratoma in B6C3F1 mice: a case report. ( 8378711 )
1993
13
Ovarian choriocarcinoma: a difficult diagnosis of an unusual tumor and a review of the hook effect. ( 1689478 )
1990
14
Ovarian choriocarcinoma in the mouse. ( 3300005 )
1987
15
Anterior segment metastases from an ovarian choriocarcinoma. ( 572142 )
1979
16
Primary ovarian choriocarcinoma (a case report). ( 4477193 )
1974
17
Primary ovarian choriocarcinoma. ( 5394205 )
1969

Variations for Choriocarcinoma of Ovary

Expression for Choriocarcinoma of Ovary

Search GEO for disease gene expression data for Choriocarcinoma of Ovary.

Pathways for Choriocarcinoma of Ovary

Pathways related to Choriocarcinoma of Ovary according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.73 CSH1 NCAM1 PRL TEK
2
Show member pathways
11.76 CSH1 CSH2 PRL TEK
3
Show member pathways
11.7 CSH1 CSH2 PRL
4
Show member pathways
11.58 CSH1 CSH2 PRL
5 11.37 ENO2 TEK
6
Show member pathways
10.87 CSH1 PRL

GO Terms for Choriocarcinoma of Ovary

Cellular components related to Choriocarcinoma of Ovary according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.46 CSH1 CSH2 ENO2 PRL
2 extracellular region GO:0005576 9.35 CSH1 CSH2 NCAM1 PRL TEK
3 endosome lumen GO:0031904 8.62 CSH1 PRL

Biological processes related to Choriocarcinoma of Ovary according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.58 CSH1 CSH2 PRL
2 negative regulation of angiogenesis GO:0016525 9.48 PRL TEK
3 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.46 CSH1 CSH2
4 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.43 CSH1 CSH2
5 animal organ development GO:0048513 9.37 CSH1 CSH2
6 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 9.32 CSH1 PRL
7 growth hormone receptor signaling pathway GO:0060396 9.26 CSH1 CSH2
8 positive regulation of growth GO:0045927 9.16 CSH1 CSH2
9 response to nutrient levels GO:0031667 9.13 CSH1 CSH2 PRL
10 positive regulation of JAK-STAT cascade GO:0046427 8.8 CSH1 CSH2 PRL

Molecular functions related to Choriocarcinoma of Ovary according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.16 NCAM1 TEK
2 growth hormone receptor binding GO:0005131 8.96 CSH1 CSH2
3 hormone activity GO:0005179 8.8 CSH1 CSH2 PRL

Sources for Choriocarcinoma of Ovary

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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