MCID: CHR075
MIFTS: 37

Choriocarcinoma of Ovary

Categories: Cancer diseases, Endocrine diseases, Fetal diseases, Reproductive diseases

Aliases & Classifications for Choriocarcinoma of Ovary

MalaCards integrated aliases for Choriocarcinoma of Ovary:

Name: Choriocarcinoma of Ovary 12 15 73
Ovarian Choriocarcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5550
NCIt 50 C4515
UMLS 73 C0346181

Summaries for Choriocarcinoma of Ovary

Disease Ontology : 12 A malignant ovarian germ cell neoplasm that has material basis in trophoblastic cells.

MalaCards based summary : Choriocarcinoma of Ovary, also known as ovarian choriocarcinoma, is related to non-gestational ovarian choriocarcinoma and choriocarcinoma. An important gene associated with Choriocarcinoma of Ovary is TEK (TEK Receptor Tyrosine Kinase), and among its related pathways/superpathways are Cytokine Signaling in Immune system and PI3K-Akt signaling pathway. The drugs Cyclophosphamide and Captopril have been mentioned in the context of this disorder. Affiliated tissues include ovary, bone and bone marrow.

Related Diseases for Choriocarcinoma of Ovary

Diseases related to Choriocarcinoma of Ovary via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 63)
# Related Disease Score Top Affiliating Genes
1 non-gestational ovarian choriocarcinoma 33.2 NCAM1 PRL SRY TEK
2 choriocarcinoma 30.3 CSH1 CSH2
3 non-gestational choriocarcinoma 29.8 CSH1 CSH2
4 gestational ovarian choriocarcinoma 12.3
5 primary non-gestational choriocarcinoma of ovary 12.2
6 childhood choriocarcinoma of the ovary 11.2
7 ectopic pregnancy 10.3
8 ovarian primitive germ cell tumor 10.1 SRY TEK
9 sex differentiation disease 10.1 PRL SRY
10 head injury 10.1 ENO2 PRL
11 gynecomastia 10.1 PRL SRY
12 tracheal cancer 10.1 ENO2 SRY
13 dysgerminoma 10.1 ENO2 SRY
14 granulosa cell tumor of the ovary 10.1 ENO2 PRL
15 cystadenofibroma 10.0 NCAM1 SRY
16 teratoma 10.0
17 multiple mucosal neuroma 10.0 ENO2 NCAM1
18 lung meningioma 10.0 ENO2 NCAM1
19 gallbladder small cell carcinoma 10.0 ENO2 NCAM1
20 small cell carcinoma 10.0 ENO2 NCAM1
21 cutaneous ganglioneuroma 10.0 ENO2 NCAM1
22 ganglioneuroma 10.0 ENO2 NCAM1
23 extrahepatic bile duct adenocarcinoma 10.0 ENO2 NCAM1
24 orbital cancer 10.0 ENO2 NCAM1
25 amenorrhea 10.0 PRL SRY
26 endometrial small cell carcinoma 10.0 ENO2 NCAM1
27 middle cerebral artery infarction 10.0 ENO2 NCAM1
28 angiomyoma 10.0 ENO2 NCAM1
29 cervical clear cell adenocarcinoma 10.0 ENO2 NCAM1
30 gastric small cell carcinoma 10.0 ENO2 NCAM1
31 subependymoma 10.0 ENO2 NCAM1
32 gastric squamous cell carcinoma 10.0 ENO2 NCAM1
33 rete testis neoplasm 10.0 ENO2 NCAM1
34 cervix small cell carcinoma 10.0 ENO2 NCAM1
35 gonadal disease 10.0 PRL SRY
36 cranial nerve malignant neoplasm 10.0 ENO2 NCAM1
37 large cell neuroendocrine carcinoma 10.0 ENO2 NCAM1
38 mixed ductal-endocrine carcinoma 10.0 ENO2 NCAM1
39 ileum cancer 10.0 ENO2 NCAM1
40 lung benign neoplasm 10.0 ENO2 NCAM1
41 premature ovarian failure 1 10.0 PRL SRY
42 testicular trophoblastic tumor 10.0 CSH1 CSH2
43 autonomic nervous system neoplasm 10.0 ENO2 NCAM1
44 peripheral nervous system neoplasm 9.9 ENO2 NCAM1
45 choriocarcinoma of the testis 9.9 CSH1 CSH2
46 large cell carcinoma 9.9 ENO2 NCAM1
47 gestational trophoblastic neoplasm 9.9 CSH1 CSH2
48 chronic salpingitis 9.9 CSH1 CSH2
49 rh isoimmunization 9.9 CSH1 CSH2
50 gestational choriocarcinoma 9.9

Graphical network of the top 20 diseases related to Choriocarcinoma of Ovary:



Diseases related to Choriocarcinoma of Ovary

Symptoms & Phenotypes for Choriocarcinoma of Ovary

Drugs & Therapeutics for Choriocarcinoma of Ovary

Drugs for Choriocarcinoma of Ovary (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 76)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyclophosphamide Approved, Investigational Phase 3,Phase 2 6055-19-2, 50-18-0 2907
2
Captopril Approved Phase 3 62571-86-2 44093
3
Ribavirin Approved Phase 3 36791-04-5 37542
4
Palivizumab Approved, Investigational Phase 3 188039-54-5
5
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
6
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
7
Itraconazole Approved, Investigational Phase 3 84625-61-6 55283
8
Caspofungin Approved Phase 3 179463-17-3, 162808-62-0 468682 2826718
9
Amphotericin B Approved, Investigational Phase 3 1397-89-3 5280965 14956
10
Carboplatin Approved Phase 3,Phase 2 41575-94-4 10339178 38904 498142
11
Cisplatin Approved Phase 3,Phase 2 15663-27-1 2767 441203 84093
12
Bleomycin Approved, Investigational Phase 3 11056-06-7 5360373
13
Etoposide Approved Phase 3 33419-42-0 36462
14 Antihypertensive Agents Phase 3
15 Antineoplastic Agents, Alkylating Phase 3,Phase 2
16 Alkylating Agents Phase 3,Phase 2
17 Immunologic Factors Phase 3,Phase 2,Phase 1
18
protease inhibitors Phase 3
19 Antirheumatic Agents Phase 3
20 HIV Protease Inhibitors Phase 3
21 Immunosuppressive Agents Phase 3,Phase 1,Phase 2
22 Angiotensin-Converting Enzyme Inhibitors Phase 3
23 Immunoglobulins Phase 3,Phase 1
24 Antimetabolites Phase 3
25 Antibodies Phase 3,Phase 1
26 Anti-Infective Agents Phase 3,Phase 2
27 Antibodies, Monoclonal Phase 3,Phase 1
28 Antiviral Agents Phase 3,Phase 2
29 Cytochrome P-450 CYP2C9 Inhibitors Phase 3
30 Cytochrome P-450 CYP3A Inhibitors Phase 3
31 Steroid Synthesis Inhibitors Phase 3
32 Cytochrome P-450 Enzyme Inhibitors Phase 3
33 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 1,Phase 2
34
Hydroxyitraconazole Phase 3
35 Hormones Phase 3,Phase 1,Phase 2
36 Antifungal Agents Phase 3
37 Hormone Antagonists Phase 3,Phase 1,Phase 2
38 Cytochrome P-450 CYP2C19 Inhibitors Phase 3
39 Liposomal amphotericin B Phase 3
40 Anti-Bacterial Agents Phase 3
41 Antiparasitic Agents Phase 3
42 Antiprotozoal Agents Phase 3
43 Echinocandins Phase 3
44 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Phase 1
45 Antimitotic Agents Phase 3,Phase 2,Phase 1
46 Keratolytic Agents Phase 3
47 Antibiotics, Antitubercular Phase 3
48 Podophyllotoxin Phase 3 518-28-5
49 Etoposide phosphate Phase 3
50 Topoisomerase Inhibitors Phase 3

Interventional clinical trials:

(show all 21)
# Name Status NCT ID Phase Drugs
1 Captopril in Treating Patients Undergoing Bone Marrow or Stem Cell Transplantation Completed NCT00004230 Phase 3 captopril;cyclophosphamide
2 Ribavirin With or Without Monoclonal Antibody Therapy in Treating Patients Who Develop RSV Pneumonia Following Peripheral Stem Cell Transplantation Completed NCT00014391 Phase 3 ribavirin
3 Itraconazole Compared With Fluconazole to Prevent Infections in Patients Undergoing Peripheral Stem Cell or Bone Marrow Transplantation Completed NCT00003883 Phase 3 fluconazole;itraconazole
4 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
5 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3 liposomal amphotericin B
6 Active Surveillance, Bleomycin, Carboplatin, Etoposide, or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors Recruiting NCT03067181 Phase 3 Bleomycin;Carboplatin;Cisplatin;Etoposide
7 Combination Chemotherapy in Treating Young Patients With Recurrent or Resistant Malignant Germ Cell Tumors Completed NCT00467051 Phase 2 Carboplatin;Ifosfamide;Paclitaxel
8 Sunitinib in Treating Patients With Metastatic Germ Cell Tumors That Have Relapsed or Not Responded to Treatment Completed NCT00453310 Phase 2 sunitinib malate
9 Combination Chemotherapy and Pegfilgrastim in Treating Patients With Previously Untreated Germ Cell Tumors Completed NCT00470366 Phase 2 cisplatin;ifosfamide;paclitaxel
10 Immunotherapy in Treating Patients Who Are Undergoing Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00002673 Phase 2
11 Lymphocyte Infusion in Treating Patients With Relapsed Cancer After Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00003887 Phase 2
12 Beclomethasone in Treating Patients With Graft-Versus-Host Disease of the Esophagus, Stomach, Small Intestine, or Colon Completed NCT00010283 Phase 1, Phase 2 beclomethasone dipropionate
13 Interleukin-11 Plus Filgrastim Prior to Peripheral Stem Cell Transplantation in Patients With Non-Hodgkin's Lymphoma, Hodgkin's Disease, Breast Cancer, or Other Solid Tumors Completed NCT00004157 Phase 2
14 Biological Therapy Following Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Cancer Completed NCT00003408 Phase 2
15 Ipilimumab After Allogeneic Stem Cell Transplant in Treating Patients With Persistent or Progressive Cancer Completed NCT00060372 Phase 1 ipilimumab;therapeutic allogeneic lymphocytes
16 Lapatinib and Paclitaxel in Treating Patients With Advanced Solid Tumors Completed NCT00313599 Phase 1 lapatinib;paclitaxel
17 Interleukin-12 in Treating Patients With Hematologic Cancers or Solid Tumors Completed NCT00003107 Phase 1
18 DNA Analysis in Samples From Younger Patients With Germ Cell Tumors and Their Parents or Siblings Completed NCT01434355
19 Changes in Brain Function in Patients With Stage I, Stage II, Stage III, or Stage IV Ovarian, Primary Peritoneal, or Fallopian Tube Cancer Who Are Receiving Chemotherapy Completed NCT01080521
20 Acupuncture in Treating Mucositis-Related Pain Caused by Chemotherapy in Patients Undergoing Stem Cell Transplantation Completed NCT00060021 Not Applicable
21 Standard Follow-up Compared With Extended Follow-up in Treating Patients Who Have Undergone Stem Cell Transplantation for Cancer Completed NCT00049465 Not Applicable

Search NIH Clinical Center for Choriocarcinoma of Ovary

Genetic Tests for Choriocarcinoma of Ovary

Anatomical Context for Choriocarcinoma of Ovary

MalaCards organs/tissues related to Choriocarcinoma of Ovary:

41
Ovary, Bone, Bone Marrow, Lung, Cervix, Testis, Placenta

Publications for Choriocarcinoma of Ovary

Articles related to Choriocarcinoma of Ovary:

(show all 18)
# Title Authors Year
1
The encouraging prognosis of nongestational ovarian choriocarcinoma with lung metastases. ( 24937961 )
2014
2
Management of non-gestational ovarian choriocarcinoma: laparoscopy can be essential. Report of two cases. ( 20561742 )
2010
3
Pure choriocarcinoma of ovary diagnosed by fine needle aspiration cytology. ( 19679980 )
2009
4
Pure nongestational choriocarcinoma of ovary. ( 14991382 )
2005
5
Pure ovarian choriocarcinoma: a difficult diagnosis of an unusual tumor presenting with acute abdomen in a 13-year-old girl. ( 15059168 )
2004
6
Primary pure ovarian choriocarcinoma mimicking ectopic pregnancy: a report of fulminant progression. ( 15143987 )
2004
7
Imaging of pure primary ovarian choriocarcinoma. ( 15150023 )
2004
8
Ovarian choriocarcinoma arising from partial mole as evidenced by deoxyribonucleic acid microsatellite analysis. ( 14672475 )
2003
9
Pure non-gestational choriocarcinoma of ovary a case report with autopsy findings. ( 12035382 )
2001
10
Nongestational pure ovarian choriocarcinoma with contralateral teratoma. ( 11161870 )
2001
11
Salvage liver surgery of a chemorefractory ovarian choriocarcinoma. ( 9103412 )
1997
12
Pure choriocarcinoma of ovary, probably non-gestational in origin. ( 7781102 )
1995
13
Spontaneous ovarian choriocarcinoma, yolk sac carcinoma, and teratoma in B6C3F1 mice: a case report. ( 8378711 )
1993
14
Ovarian choriocarcinoma: a difficult diagnosis of an unusual tumor and a review of the hook effect. ( 1689478 )
1990
15
Ovarian choriocarcinoma in the mouse. ( 3300005 )
1987
16
Anterior segment metastases from an ovarian choriocarcinoma. ( 572142 )
1979
17
Primary ovarian choriocarcinoma (a case report). ( 4477193 )
1974
18
Primary ovarian choriocarcinoma. ( 5394205 )
1969

Variations for Choriocarcinoma of Ovary

Expression for Choriocarcinoma of Ovary

Search GEO for disease gene expression data for Choriocarcinoma of Ovary.

Pathways for Choriocarcinoma of Ovary

Pathways related to Choriocarcinoma of Ovary according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.73 CSH1 NCAM1 PRL TEK
2
Show member pathways
11.77 CSH1 CSH2 PRL TEK
3
Show member pathways
11.7 CSH1 CSH2 PRL
4
Show member pathways
11.58 CSH1 CSH2 PRL
5 11.37 ENO2 TEK
6
Show member pathways
10.87 CSH1 PRL

GO Terms for Choriocarcinoma of Ovary

Cellular components related to Choriocarcinoma of Ovary according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.35 CSH1 CSH2 NCAM1 PRL TEK
2 endosome lumen GO:0031904 8.62 CSH1 PRL

Biological processes related to Choriocarcinoma of Ovary according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.61 CSH1 CSH2 PRL
2 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.46 CSH1 CSH2
3 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.4 CSH1 CSH2
4 animal organ development GO:0048513 9.37 CSH1 CSH2
5 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 9.32 CSH1 PRL
6 growth hormone receptor signaling pathway GO:0060396 9.26 CSH1 CSH2
7 positive regulation of growth GO:0045927 9.16 CSH1 CSH2
8 response to nutrient levels GO:0031667 9.13 CSH1 CSH2 PRL
9 positive regulation of JAK-STAT cascade GO:0046427 8.8 CSH1 CSH2 PRL

Molecular functions related to Choriocarcinoma of Ovary according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth hormone receptor binding GO:0005131 8.96 CSH1 CSH2
2 hormone activity GO:0005179 8.8 CSH1 CSH2 PRL

Sources for Choriocarcinoma of Ovary

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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