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MCID: CHR076
MIFTS: 32

Choriocarcinoma of the Testis

Categories: Cancer diseases, Fetal diseases, Reproductive diseases
Genes Tissues Related diseases Publications Drugs
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Aliases & Classifications for Choriocarcinoma of the Testis

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MalaCards integrated aliases for Choriocarcinoma of the Testis:

Name: Choriocarcinoma of the Testis 12 15 70
Testicular Choriocarcinoma 12 17

Classifications:

MalaCards categories:
Global: Cancer diseases Fetal diseases
Anatomical: Reproductive diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:5551
NCIt 50 C7733
SNOMED-CT 67 147371000119101
UMLS 70 C0238449
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Summaries for Choriocarcinoma of the Testis

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Disease Ontology : 12 A choriocarcinoma that is located in the testis.

MalaCards based summary : Choriocarcinoma of the Testis, also known as testicular choriocarcinoma, is related to choriocarcinoma and mature teratoma. An important gene associated with Choriocarcinoma of the Testis is AFP (Alpha Fetoprotein). The drugs Palivizumab and Ribavirin have been mentioned in the context of this disorder. Affiliated tissues include testis, bone marrow and bone.

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Related Diseases for Choriocarcinoma of the Testis

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Diseases related to Choriocarcinoma of the Testis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 70)
# Related Disease Score Top Affiliating Genes
1 choriocarcinoma 30.7 CSH2 CSH1
2 mature teratoma 30.1 SALL4 AFP
3 childhood choriocarcinoma of the testis 11.6
4 testicular monophasic choriocarcinoma 11.2
5 germ cells tumors 10.5
6 mixed germ cell tumor 10.3
7 testicular cancer 10.2
8 testicular germ cell tumor 10.1
9 extragonadal seminoma 10.1 SALL4 AFP
10 ovarian primitive germ cell tumor 10.1 SALL4 AFP
11 ovarian endodermal sinus tumor 10.1 SALL4 AFP
12 endodermal sinus tumor 10.1 SALL4 AFP
13 mixed germ cell cancer 10.1 SALL4 AFP
14 germ cell cancer 10.1 SALL4 AFP
15 testicular malignant germ cell cancer 10.1 SALL4 AFP
16 central nervous system germ cell tumor 10.1 SALL4 AFP
17 ovarian germ cell cancer 10.1 SALL4 AFP
18 malignant teratoma 10.0 SALL4 AFP
19 graves disease 1 10.0
20 active peptic ulcer disease 10.0
21 hyperthyroidism 10.0
22 nonseminomatous germ cell tumor 10.0
23 hepatoid adenocarcinoma 10.0 SALL4 AFP
24 infant gynecomastia 10.0
25 gynecomastia 10.0
26 cholestasis 10.0
27 obstructive jaundice 10.0
28 teratoma 10.0
29 hydrocele 10.0
30 spermatocytoma 10.0 SALL4 AFP
31 germinoma 10.0 SALL4 AFP
32 benign teratoma 10.0 SALL4 AFP
33 dysgerminoma 10.0 SALL4 AFP
34 intussusception 9.9
35 lipomatosis, multiple 9.9
36 retinal detachment 9.9
37 gastric cancer 9.9
38 ptosis 9.9
39 pleomorphic lipoma 9.9
40 hydronephrosis 9.9
41 arteriovenous malformation 9.9
42 pulmonary edema 9.9
43 acute leukemia 9.9
44 scleritis 9.9
45 seminoma 9.9
46 pulmonary embolism 9.9
47 tetraploidy 9.9
48 anencephaly 9.9 FOLR1 AFP
49 gestational choriocarcinoma 9.8 CSH2 CSH1
50 testicular trophoblastic tumor 9.8 CSH2 CSH1

Graphical network of the top 20 diseases related to Choriocarcinoma of the Testis:



Diseases related to Choriocarcinoma of the Testis
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Symptoms & Phenotypes for Choriocarcinoma of the Testis

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Drugs & Therapeutics for Choriocarcinoma of the Testis

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Drugs for Choriocarcinoma of the Testis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 76)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Palivizumab Approved, Investigational Phase 3 188039-54-5
2
Ribavirin Approved Phase 3 36791-04-5 37542
3
Captopril Approved Phase 3 62571-86-2 44093
4
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
5
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
6
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
7
Clotrimazole Approved, Vet_approved Phase 3 23593-75-1 2812
8
Itraconazole Approved, Investigational Phase 3 84625-61-6 55283
9
Lenograstim Approved, Investigational Phase 3 135968-09-1
10
Carboplatin Approved Phase 3 41575-94-4 10339178 498142 38904
11
Caspofungin Approved Phase 3 179463-17-3, 162808-62-0 468682 2826718
12
Amphotericin B Approved, Investigational Phase 3 1397-89-3 14956 5280965
13
Etoposide Approved Phase 3 33419-42-0 36462
14
Bleomycin Approved, Investigational Phase 3 11056-06-7 5360373
15
Oxaliplatin Approved, Investigational Phase 3 61825-94-3 5310940 9887054 43805 6857599
16
Cisplatin Approved Phase 3 15663-27-1 84093 441203 2767
17
Paclitaxel Approved, Vet_approved Phase 3 33069-62-4 36314
18
Ifosfamide Approved Phase 3 3778-73-2 3690
19
Vinblastine Approved Phase 3 865-21-4 241903 13342
20 Antibodies Phase 3
21 Immunoglobulins Phase 3
22 Anti-Infective Agents Phase 3
23 Antiviral Agents Phase 3
24 Antimetabolites Phase 3
25 Antibodies, Monoclonal Phase 3
26 Immunosuppressive Agents Phase 3
27 Hormones Phase 3
28 Hormone Antagonists Phase 3
29 Immunologic Factors Phase 3
30
protease inhibitors Phase 3
31 Angiotensin-Converting Enzyme Inhibitors Phase 3
32 Antirheumatic Agents Phase 3
33 Antihypertensive Agents Phase 3
34 HIV Protease Inhibitors Phase 3
35 Cytochrome P-450 CYP3A Inhibitors Phase 3
36
Hydroxyitraconazole Phase 3 108222
37 Cytochrome P-450 Enzyme Inhibitors Phase 3
38 Antifungal Agents Phase 3
39 Amebicides Phase 3
40 Antiparasitic Agents Phase 3
41 Liposomal amphotericin B Phase 3
42 Antiprotozoal Agents Phase 3
43 Liver Extracts Phase 3
44 Antibiotics, Antitubercular Phase 3
45 Etoposide phosphate Phase 3
46 Anti-Bacterial Agents Phase 3
47 Tubulin Modulators Phase 3
48 Alkylating Agents Phase 3
49 Albumin-Bound Paclitaxel Phase 3
50 Antimitotic Agents Phase 3

Interventional clinical trials:

(show all 28)
# Name Status NCT ID Phase Drugs
1 Randomized Phase II/III Study of Taxol/Paclitaxel-BEP Versus BEP in Patients With Intermediate Prognosis Germ Cell Cancer Unknown status NCT00003643 Phase 2, Phase 3 cisplatin;etoposide;paclitaxel
2 A Randomized Double-Blind Placebo-Controlled Phase III Study To Evaluate The Safety And Efficacy Of Palivizumab Combined With Aerosolized Ribavirin Compared To Ribavirin Alone To Treat RSV Pneumonia In Patients With Bone Marrow Transplants (BMT) Completed NCT00014391 Phase 3 ribavirin
3 Phase III Study of Captopril in Patients Undergoing Autologous Bone Marrow/Stem Cell Transplantation Completed NCT00004230 Phase 3 captopril;cyclophosphamide
4 A Randomized, Comparative Study of Itraconazole Versus Fluconazole for Prevention of Aspergillus Infections in Peripheral Blood Stem Cell and Marrow Transplant Recipients Completed NCT00003883 Phase 3 fluconazole;itraconazole
5 A Multicenter, Double-Blind, Randomized, Comparative Study To Evaluate The Safety, Tolerability, And Efficacy Of MK-0991 Versus (Amphotericin B) Liposome For Injection As Empirical Therapy In Patients With Persistent Fever And Neutropenia Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
6 A Randomized Phase III Study of Sequential High-Dose Cisplatinum/Etoposide/Ifosfamide Plus Stem Cell Support Versus BEP in Patients With Poor Prognosis Germ Cell Cancer Completed NCT00003941 Phase 3 cisplatin;etoposide;ifosfamide
7 A Strategic Study to Determine the Optimal Moment to Initiate Systemic Antifungal Therapy With Ambisome in Granulocytopenic Cancer Patients With Unexplained Fever Refractory to Empirical Antibacterials Completed NCT00003938 Phase 3 liposomal amphotericin B
8 RANDOMIZED MULTIINSTITUTIONAL PHASE III TRIAL OF BEP AND HIGH DOSE CHEMOTHERAPY VERSUS BEP ALONE IN PREVIOUSLY UNTREATED PATIENTS WITH POOR RISK GERM CELL TUMORS Completed NCT00002596 Phase 3 carboplatin;cisplatin;cyclophosphamide;etoposide
9 A Risk-Adapted Strategy of the Use of Dose-Dense Chemotherapy in Patients With Poor-Prognosis Disseminated Non-Seminomatous Germ Cell Tumors Active, not recruiting NCT00104676 Phase 3 cisplatin;etoposide;ifosfamide;oxaliplatin;paclitaxel
10 A Randomized Phase III Study of Paclitaxel, Ifosfamide and Cisplatin Versus Vinblastine, Ifosfamide and Cisplatin as Second-Line Therapy for Patients With Relapsed/Resistant Germ Cell Tumors Terminated NCT00072215 Phase 3 cisplatin;ifosfamide;paclitaxel;vinblastine
11 A Phase II Study of Sunitinib in Patients With Refractory or Relapsed Germ Cell Tumors Completed NCT00453310 Phase 2 sunitinib malate
12 Accelerated BEP Chemotherapy for Intermediate and High Risk Metastatic Germ Cell Tumor Completed NCT00453232 Phase 2 cisplatin;etoposide
13 Oral Beclomethasone Dipropionate Capsules for Treatment of Intestinal Graft-Versus-Host Disease: Compassionate Use in Patients With Contraindictions to High-Dose Immunosuppressive Therapy Completed NCT00010283 Phase 1, Phase 2 beclomethasone dipropionate
14 Cytokine-Based Immunotherapy Following High-Dose Chemotherapy and Autologous Stem Cell Transplantation Completed NCT00003408 Phase 2
15 Donor Lymphocyte Infusion (DLI) as Adoptive Immunotherapy for Relapse Malignancies After Allogeneic Hematopoietic Transplantation Completed NCT00003887 Phase 2
16 Tandem High-Dose Chemotherapy With Autologous Stem Cell Rescue for Poor-Prognosis Germ Cell Cancer Completed NCT00002931 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel
17 A PHASE II STUDY OF CELLULAR ADOPTIVE IMMUNOTHERAPY AS PROPHYLAXIS FOR CYTOMEGALOVIRUS DISEASE AFTER ALLOGENEIC BONE MARROW TRANSPLANTATION Completed NCT00002673 Phase 2
18 Randomized Phase II Trial of Intensive Induction Chemotherapy (CBOP/BEP) and Standard BEP Chemotherapy in Poor Prognosis Male Germ Cell Tumors Completed NCT00301782 Phase 2 carboplatin;cisplatin;etoposide phosphate;vincristine sulfate
19 A Phase II Study of BMS-247550 In Advanced Germ Cell Tumor Patients - THERAPEUTIC/DIAGNOSTIC PROTOCOL Completed NCT00070096 Phase 2 ixabepilone
20 Phase II Trial of Paclitaxel, Ifosfamide, and Cisplatin in Previously Untreated Intermediate and Poor Risk Germ Cell Tumor Patients Completed NCT00470366 Phase 2 cisplatin;ifosfamide;paclitaxel
21 A Study of Paclitaxel, Cisplatin and Ifosfamide as Induction Therapy in the Treatment of Patients Relapsing After BEP Chemotherapy for Metastatic Germ Cell Tumors Completed NCT00004077 Phase 2 cisplatin;ifosfamide;paclitaxel
22 Combination of Interleukin 11 (Neumega) With G-CSF to Mobilize Autologous Peripheral Blood Stem Cells (PBSC) Completed NCT00004157 Phase 2
23 Autologous Peripheral Blood Stem Cell Transplant for Germ Cell Tumors Active, not recruiting NCT00432094 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel;thiotepa;Mesna
24 A Phase I Trial of Recombinant Human Interleukin-12 After High-Dose Therapy and Autologous Hematopoietic Stem Cell Support Completed NCT00003107 Phase 1
25 Multi-Site Randomized Clinical Trial Comparing Standard Recovery Preparation to Extended Recovery Preparation to Enhance Long Term Function After Marrow or Stem Cell Transplant Completed NCT00049465
26 A Study Of 18 FDG PET In The Prediction Of Relapse In Patients With A Clinical Stage I Non-Seminomatous Germ Cell Tumor Completed NCT00045045
27 A Randomized, Placebo-Controlled, Blinded Study Of Acupuncture Therapy In Mucositis-Related Pain In Patients Undergoing Hematopoietic Stem Cell Transplantation Completed NCT00060021
28 Correlation of Histopathology, Immunohistochemistry and Quantitative Radiology With Outcome in Early Stage Nonseminomatous Germ Cell Tumor Completed NCT00003800

Search NIH Clinical Center for Choriocarcinoma of the Testis

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Genetic Tests for Choriocarcinoma of the Testis

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Anatomical Context for Choriocarcinoma of the Testis

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The Foundational Model of Anatomy Ontology organs/tissues related to Choriocarcinoma of the Testis:

19
Testis

MalaCards organs/tissues related to Choriocarcinoma of the Testis:

40
Testis, Bone Marrow, Bone, Liver, Lymph Node, Spleen
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Publications for Choriocarcinoma of the Testis

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Articles related to Choriocarcinoma of the Testis:

(show top 50) (show all 119)
# Title Authors PMID Year
1
Pure testicular choriocarcinoma Cannonball metastases as a presenting imaging feature: A case report and a review of literature. 61
33613805 2021
2
Metastatic testicular choriocarcinoma to the rectum requiring diverting colostomy. 61
33629509 2021
3
18F-FDG PET/CT Imaging of Metastatic Testicular Choriocarcinoma Mimicking Gastric Cancer which Initial Symptom is Melena 61
33586408 2021
4
Metastatic testicular choriocarcinoma presenting as eyelid swelling and ptosis. 61
33632056 2021
5
Gastrointestinal Bleeding Secondary to Metastatic Duodenal Choriocarcinoma in a Patient with Concomitant Peptic Ulcer Disease. 61
33763267 2021
6
Clinicopathological characteristics and survival outcomes for testicular choriocarcinoma: a population-based study. 61
33532328 2021
7
Frequent EGFR expression/EGFR amplification and lack of activating mutation in testicular choriocarcinoma. 61
31994813 2020
8
Gastrointestinal Bleeding with Hemodynamic Repercussion due to a Gastric Metastatic Lesion of a Testicular Choriocarcinoma in a Previously Asymptomatic Young Adult. 61
32509930 2020
9
Head and neck cutaneous metastasis of testicular choriocarcinoma. 61
32102892 2020
10
Thyroid Storm Associated with Testicular Choriocarcinoma. 61
33083353 2020
11
Genital exam, a missed piece of the puzzle in medical diagnosis, can be lifesaving in men: A lesson from a case of a state of shock due to duodenal metastasis of testicular choriocarcinoma. 61
33282715 2020
12
Bilateral wunderlich syndrome secondary to synchronous bilateral testicular germ cell tumor. A case report. 61
31641608 2020
13
Testicular Choriocarcinoma Metastasizing to the Small Bowel Causing Intussusception: Case Report. 61
30368692 2019
14
A Unique Case of Orthostasis in a Patient with Testicular Choriocarcinoma. 61
32789302 2019
15
Metastatic Testicular Choriocarcinoma: An Unusual Cause of Upper Gastrointestinal Bleed. 61
31565641 2019
16
Acute pulmonary hemorrhage associated with metastatic testicular choriocarcinoma in a 46-year-old incarcerated male. 61
30787584 2019
17
Cutaneous Metastasis of Choriocarcinoma in 2 Male Patients: A Rare Presentation of an Aggressive Malignancy That Dermatopathologists Must Recognize. 61
29944473 2019
18
Pure testicular choriocarcinoma presenting as a friable hemorrhagic nodule on the lip. 61
30128343 2018
19
Pure Testicular Choriocarcinoma with Dermatological, Brain, and Gastrointestinal Metastases. 61
30324039 2018
20
Testicular choriocarcinoma with cutaneous metastasis in a 19-year-old man. 61
29665032 2018
21
Cutaneous and systematic metastasis of testicular choriocarcinoma: Case report and literature review. 61
29851778 2018
22
Spontaneous renal hemorrhage secondary to choriocarcinoma in a man with congenital hypospadias and cryptorchidism: a case report and literature review. 61
29739453 2018
23
Pitfalls in Diagnosis and Management of Testicular Choriocarcinoma Metastatic to the Brain: Report of 2 Cases and Review of Literature. 61
28712904 2017
24
Metastatic choriocarcinoma induced separate simultaneous intracerebral haemorrhages: a very rare occurrence and its novel association with Klinefelter syndrome. 61
26564116 2015
25
Metastatic Testicular Choriocarcinoma: A Rare Cause of Upper GI Bleeding. 61
26504875 2015
26
Hemorrhagic collision metastasis in a cerebral arteriovenous malformation. 61
25261441 2015
27
Pericardial tamponade caused by tumor hemorrhage--a rare complication of metastatic testicular choriocarcinoma. 61
25260397 2015
28
Testicular choriocarcinoma metastatic to the stomach: cytological, histological and immunocyto-histochemical findings. 61
24262032 2015
29
Testicular choriocarcinoma: a rare variant that requires a unique treatment approach. 61
25645112 2015
30
A Literature Review and Case Report of Metastatic Pure Choriocarcinoma. 61
26649213 2015
31
Hemorrhagic collision metastasis in a cerebral arteriovenous malformation. 61
25239982 2014
32
Choriocarcinoma of the testis. 61
24949806 2014
33
HLA-G in testicular germ cell tumors. 61
24853783 2014
34
Testicular choriocarcinoma: diagnosed on cervical lymph node biopsy. 61
24397105 2013
35
Testicular choriocarcinoma presenting as hyperthyroidism. 61
24157290 2013
36
A case of gastrointestinal bleeding due to duodenal metastasis from a testicular choriocarcinoma. 61
22961707 2013
37
[Hemoptysis revealing an endobronchial metastasis of testicular choriocarcinoma]. 61
23318195 2013
38
Pure choriocarcinoma of the testis presenting with jaundice: a case report and review of the literature. 61
22938171 2012
39
Testicular choriocarcinoma: an unusual case of paraneoplastic thyrotoxicosis. 61
21652536 2012
40
Cutaneous metastasis of testicular choriocarcinoma, diagnosed by fine-needle aspiration cytology: a rare case report and review of the literature. 61
23032847 2012
41
Testicular choriocarcinoma resembling a lipoma. 61
22507580 2012
42
Choroidal metastasis as the presenting feature in a case of testicular choriocarcinoma. 61
23961001 2012
43
Choroidal metastases in testicular choriocarcinoma, successful treatment with chemo- and radiotherapy: a case report. 61
22151977 2011
44
Cutaneous and systemic metastasis of a testicular choriocarcinoma. 61
20571348 2010
45
Testicular choriocarcinoma metastatic to skin and multiple organs. Two case reports and review of literature. 61
19469863 2010
46
Image of the month. Upper gastrointestinal bleeding caused by metastatic testicular choriocarcinoma. 61
19447198 2010
47
Uncommon mucosal metastases to the stomach. 61
19650900 2009
48
Uveal metastasis from testicular choriocarcinoma presenting as scleritis. 61
19491960 2009
49
[Case of metastatic germ cell tumor with testicular calcification detected by MD-CT]. 61
18939415 2008
50
Improved systemic chemotherapy for metastatic testicular choriocarcinoma can result in excellent prognosis for life and vision. 61
18625957 2008
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Variations for Choriocarcinoma of the Testis

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Expression for Choriocarcinoma of the Testis

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Search GEO for disease gene expression data for Choriocarcinoma of the Testis.
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Pathways for Choriocarcinoma of the Testis

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GO Terms for Choriocarcinoma of the Testis

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Biological processes related to Choriocarcinoma of the Testis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to nutrient levels GO:0031667 9.37 CSH2 CSH1
2 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.32 CSH2 CSH1
3 positive regulation of JAK-STAT cascade GO:0046427 9.26 CSH2 CSH1
4 animal organ development GO:0048513 9.16 CSH2 CSH1
5 growth hormone receptor signaling pathway GO:0060396 8.96 CSH2 CSH1
6 positive regulation of growth GO:0045927 8.62 CSH2 CSH1

Molecular functions related to Choriocarcinoma of the Testis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.96 CSH2 CSH1
2 growth hormone receptor binding GO:0005131 8.62 CSH2 CSH1
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Sources for Choriocarcinoma of the Testis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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