MCID: CHR076
MIFTS: 39

Choriocarcinoma of the Testis

Categories: Cancer diseases, Fetal diseases, Reproductive diseases

Aliases & Classifications for Choriocarcinoma of the Testis

MalaCards integrated aliases for Choriocarcinoma of the Testis:

Name: Choriocarcinoma of the Testis 12 15 74
Testicular Choriocarcinoma 12 17

Classifications:



External Ids:

Disease Ontology 12 DOID:5551
NCIt 51 C7733
UMLS 74 C0238449

Summaries for Choriocarcinoma of the Testis

Disease Ontology : 12 A choriocarcinoma that is located in the testis.

MalaCards based summary : Choriocarcinoma of the Testis, also known as testicular choriocarcinoma, is related to choriocarcinoma and childhood choriocarcinoma of the testis. An important gene associated with Choriocarcinoma of the Testis is CDKN2C (Cyclin Dependent Kinase Inhibitor 2C), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Immune response Role of DAP12 receptors in NK cells. The drugs Bleomycin and Etoposide have been mentioned in the context of this disorder. Affiliated tissues include testis, bone and bone marrow.

Related Diseases for Choriocarcinoma of the Testis

Diseases related to Choriocarcinoma of the Testis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 67)
# Related Disease Score Top Affiliating Genes
1 choriocarcinoma 30.8 CSH1 CSH2 HLA-G
2 childhood choriocarcinoma of the testis 12.6
3 testicular monophasic choriocarcinoma 11.2
4 orbit lymphoma 10.3 GZMB TIA1
5 lichen sclerosus et atrophicus 10.2 GZMB TIA1
6 lymphomatoid granulomatosis 10.2 GZMB TIA1
7 viral esophagitis 10.2 GZMB TIA1
8 panniculitis 10.2 GZMB TIA1
9 primary cutaneous anaplastic large cell lymphoma 10.2 GZMB TIA1
10 composite lymphoma 10.2 GZMB TIA1
11 hepatosplenic t-cell lymphoma 10.2 GZMB TIA1
12 testicular trophoblastic tumor 10.2 CSH1 CSH2
13 natural killer cell leukemia 10.2 GZMB TIA1
14 giardiasis 10.2 GZMB TIA1
15 choriocarcinoma of ovary 10.2 CSH1 CSH2
16 infiltrating lipoma 10.2 GZMB TIA1
17 non-gestational choriocarcinoma 10.2 CSH1 CSH2
18 gestational trophoblastic neoplasm 10.2 CSH1 CSH2
19 breast medullary carcinoma 10.2 FASLG GZMB
20 angioimmunoblastic t-cell lymphoma 10.1 GZMB TIA1
21 chronic salpingitis 10.1 CSH1 CSH2
22 t-cell large granular lymphocyte leukemia 10.1 FASLG GZMB
23 reticulosarcoma 10.1 GZMB TIA1
24 erythema multiforme 10.1 FASLG GZMB
25 hyperthyroidism 10.1
26 acute graft versus host disease 10.0 FASLG GZMB
27 epithelioid trophoblastic tumor 10.0 CSH1 KRT7
28 intrahepatic bile duct adenoma 10.0 AFP KRT7
29 lymphocytic gastritis 10.0 FASLG GZMB TIA1
30 rh isoimmunization 10.0 AFP CSH1 CSH2
31 lymphomatoid papulosis 10.0 FASLG GZMB TIA1
32 renal pelvis adenocarcinoma 10.0 AFP KRT7
33 b-cell expansion with nfkb and t-cell anergy 10.0 FASLG GZMB TIA1
34 placenta disease 10.0 AFP CSH1 CSH2
35 uterine anomalies 10.0 AFP CSH1 CSH2
36 ovarian germ cell cancer 10.0 AFP KRT7
37 intratubular embryonal carcinoma 9.9 AFP KRT7
38 bile duct cystadenocarcinoma 9.9 AFP KRT7
39 thrombosis 9.9
40 seminal vesicle tumor 9.9 AFP KRT7
41 adenomatoid tumor 9.9 AFP KRT7
42 intussusception 9.9
43 lipomatosis, multiple 9.9
44 graves disease 1 9.9
45 pleomorphic lipoma 9.9
46 pulmonary edema 9.9
47 cardiac tamponade 9.9
48 scleritis 9.9
49 active peptic ulcer disease 9.9
50 ovarian endodermal sinus tumor 9.9 AFP KRT7

Graphical network of the top 20 diseases related to Choriocarcinoma of the Testis:



Diseases related to Choriocarcinoma of the Testis

Symptoms & Phenotypes for Choriocarcinoma of the Testis

Drugs & Therapeutics for Choriocarcinoma of the Testis

Drugs for Choriocarcinoma of the Testis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 96)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bleomycin Approved, Investigational Phase 2, Phase 3,Phase 3 11056-06-7 5360373
2
Etoposide Approved Phase 2, Phase 3,Phase 3 33419-42-0 36462
3
Lenograstim Approved, Investigational Phase 2, Phase 3,Phase 3,Phase 1 135968-09-1
4
Paclitaxel Approved, Vet_approved Phase 2, Phase 3,Phase 3,Phase 1 33069-62-4 36314
5
Cisplatin Approved Phase 2, Phase 3,Phase 3,Phase 1 15663-27-1 2767 441203 84093
6
Ifosfamide Approved Phase 3,Phase 1,Phase 2 3778-73-2 3690
7
Mechlorethamine Approved, Investigational Phase 3,Phase 1,Phase 2 51-75-2 4033
8
Oxaliplatin Approved, Investigational Phase 3 61825-94-3 43805 6857599 5310940 9887054
9
Carboplatin Approved Phase 3,Phase 2 41575-94-4 10339178 38904 498142
10
Cyclophosphamide Approved, Investigational Phase 3,Phase 2 50-18-0, 6055-19-2 2907
11
Captopril Approved Phase 3 62571-86-2 44093
12
Ribavirin Approved Phase 3 36791-04-5 37542
13
Palivizumab Approved, Investigational Phase 3 188039-54-5
14
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
15
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
16
Itraconazole Approved, Investigational Phase 3 84625-61-6 55283
17
Caspofungin Approved Phase 3 162808-62-0, 179463-17-3 2826718 468682
18
Amphotericin B Approved, Investigational Phase 3 1397-89-3 5280965 14956
19
Vinblastine Approved Phase 3 865-21-4 241903 13342
20 Antibiotics, Antitubercular Phase 2, Phase 3,Phase 3
21 Antimitotic Agents Phase 2, Phase 3,Phase 3,Phase 1
22 Topoisomerase Inhibitors Phase 2, Phase 3,Phase 3
23 Etoposide phosphate Phase 2, Phase 3,Phase 3
24 Anti-Bacterial Agents Phase 2, Phase 3,Phase 3
25 Albumin-Bound Paclitaxel Phase 2, Phase 3,Phase 3,Phase 1
26 Antineoplastic Agents, Phytogenic Phase 2, Phase 3,Phase 3,Phase 1
27
Isophosphamide mustard Phase 3,Phase 1,Phase 2 0
28 Alkylating Agents Phase 3,Phase 1,Phase 2
29 Antineoplastic Agents, Alkylating Phase 3,Phase 1,Phase 2
30 Immunologic Factors Phase 3,Phase 1,Phase 2
31 Immunosuppressive Agents Phase 3,Phase 1,Phase 2
32 Antiviral Agents Phase 3,Phase 1,Phase 2
33 Anti-Infective Agents Phase 3,Phase 1,Phase 2
34 Antimetabolites Phase 3,Phase 1,Phase 2
35 Liver Extracts Phase 3
36 Antirheumatic Agents Phase 3
37 Antihypertensive Agents Phase 3
38 Angiotensin-Converting Enzyme Inhibitors Phase 3
39
protease inhibitors Phase 3
40 HIV Protease Inhibitors Phase 3
41 Antibodies, Monoclonal Phase 3,Phase 1
42 Antibodies Phase 3,Phase 1
43 Immunoglobulins Phase 3,Phase 1
44 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 1,Phase 2
45 Hormone Antagonists Phase 3,Phase 1,Phase 2
46 Cytochrome P-450 CYP3A Inhibitors Phase 3
47 Cytochrome P-450 Enzyme Inhibitors Phase 3
48 Hormones Phase 3,Phase 1,Phase 2
49 Steroid Synthesis Inhibitors Phase 3
50 Cytochrome P-450 CYP2C9 Inhibitors Phase 3

Interventional clinical trials:

(show all 35)
# Name Status NCT ID Phase Drugs
1 Combination Chemotherapy in Treating Men With Germ Cell Cancer Unknown status NCT00003643 Phase 2, Phase 3 cisplatin;etoposide;paclitaxel
2 Combination Chemotherapy in Treating Patients With Stage II or Stage III Germ Cell Tumors Unknown status NCT00104676 Phase 3 cisplatin;etoposide;ifosfamide;oxaliplatin;paclitaxel
3 Combination Chemotherapy With or Without Peripheral Stem Cell Transplant in Treating Men With Previously Untreated Germ Cell Cancer Completed NCT00003941 Phase 3 cisplatin;etoposide;ifosfamide
4 Combination Chemotherapy With or Without Bone Marrow or Stem Cell Transplantation in Treating Men With Untreated Germ Cell Tumors Completed NCT00002596 Phase 3 carboplatin;cisplatin;cyclophosphamide;etoposide
5 Captopril in Treating Patients Undergoing Bone Marrow or Stem Cell Transplantation Completed NCT00004230 Phase 3 captopril;cyclophosphamide
6 Ribavirin With or Without Monoclonal Antibody Therapy in Treating Patients Who Develop RSV Pneumonia Following Peripheral Stem Cell Transplantation Completed NCT00014391 Phase 3 ribavirin
7 Itraconazole Compared With Fluconazole to Prevent Infections in Patients Undergoing Peripheral Stem Cell or Bone Marrow Transplantation Completed NCT00003883 Phase 3 fluconazole;itraconazole
8 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
9 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3 liposomal amphotericin B
10 Surgery and Combination Chemotherapy in Treating Children With Extracranial Germ Cell Tumors Completed NCT00053352 Phase 3 cisplatin;etoposide
11 Active Surveillance, Bleomycin, Carboplatin, Etoposide, or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors Recruiting NCT03067181 Phase 3 Bleomycin;Carboplatin;Cisplatin;Etoposide;Etoposide Phosphate
12 Cisplatin and Ifosfamide Combined With Either Paclitaxel or Vinblastine in Treating Men With Progressive or Recurrent Metastatic Germ Cell Tumors Terminated NCT00072215 Phase 3 cisplatin;ifosfamide;paclitaxel;vinblastine
13 Gemcitabine, Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Progressive or Relapsed Metastatic Germ Cell Tumors Unknown status NCT00551122 Phase 1, Phase 2 cisplatin;gemcitabine hydrochloride;ifosfamide;paclitaxel
14 Combination Chemotherapy and Pegfilgrastim in Treating Men With Metastatic Germ Cell Tumors Completed NCT00453232 Phase 2 cisplatin;etoposide
15 Combination Chemotherapy and Pegfilgrastim in Treating Patients With Previously Untreated Germ Cell Tumors Completed NCT00470366 Phase 2 cisplatin;ifosfamide;paclitaxel
16 Combination Chemotherapy in Treating Male Patients With Germ Cell Tumors Completed NCT00301782 Phase 2 carboplatin;cisplatin;etoposide phosphate;vincristine sulfate
17 Sunitinib in Treating Patients With Metastatic Germ Cell Tumors That Have Relapsed or Not Responded to Treatment Completed NCT00453310 Phase 2 sunitinib malate
18 Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Relapsed Germ Cell Cancer Completed NCT00002931 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel
19 Immunotherapy in Treating Patients Who Are Undergoing Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00002673 Phase 2
20 Lymphocyte Infusion in Treating Patients With Relapsed Cancer After Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00003887 Phase 2
21 Beclomethasone in Treating Patients With Graft-Versus-Host Disease of the Esophagus, Stomach, Small Intestine, or Colon Completed NCT00010283 Phase 1, Phase 2 beclomethasone dipropionate
22 Interleukin-11 Plus Filgrastim Prior to Peripheral Stem Cell Transplantation in Patients With Non-Hodgkin's Lymphoma, Hodgkin's Disease, Breast Cancer, or Other Solid Tumors Completed NCT00004157 Phase 2
23 Ixabepilone in Treating Patients With Advanced Cisplatin-Refractory Germ Cell Tumors Completed NCT00070096 Phase 2 ixabepilone
24 Biological Therapy Following Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Cancer Completed NCT00003408 Phase 2
25 Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Metastatic Testicular Cancer Completed NCT00004077 Phase 2 cisplatin;ifosfamide;paclitaxel
26 Combination Chemotherapy in Treating Young Patients With Recurrent or Resistant Malignant Germ Cell Tumors Completed NCT00467051 Phase 2 Carboplatin;Ifosfamide;Paclitaxel
27 Autologous Peripheral Blood Stem Cell Transplant for Germ Cell Tumors Recruiting NCT00432094 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel;thiotepa;Mesna
28 Role of Axumin PET Scan in Germ Cell Tumor Recruiting NCT03426865 Phase 2 Axumin PET scan
29 Ipilimumab After Allogeneic Stem Cell Transplant in Treating Patients With Persistent or Progressive Cancer Completed NCT00060372 Phase 1 ipilimumab;therapeutic allogeneic lymphocytes
30 Interleukin-12 in Treating Patients With Hematologic Cancers or Solid Tumors Completed NCT00003107 Phase 1
31 Positron Emission Tomography in Detecting Testicle Cancer Completed NCT00045045 Not Applicable
32 Acupuncture in Treating Mucositis-Related Pain Caused by Chemotherapy in Patients Undergoing Stem Cell Transplantation Completed NCT00060021 Not Applicable
33 Standard Follow-up Compared With Extended Follow-up in Treating Patients Who Have Undergone Stem Cell Transplantation for Cancer Completed NCT00049465 Not Applicable
34 Diagnostic Study of Patients With Stage I Testicular Cancer Completed NCT00003800 Not Applicable
35 DNA Analysis in Samples From Younger Patients With Germ Cell Tumors and Their Parents or Siblings Completed NCT01434355

Search NIH Clinical Center for Choriocarcinoma of the Testis

Genetic Tests for Choriocarcinoma of the Testis

Anatomical Context for Choriocarcinoma of the Testis

MalaCards organs/tissues related to Choriocarcinoma of the Testis:

42
Testis, Bone, Bone Marrow, T Cells, Breast, Liver, Colon

The Foundational Model of Anatomy Ontology organs/tissues related to Choriocarcinoma of the Testis:

20
The Testis

Publications for Choriocarcinoma of the Testis

Articles related to Choriocarcinoma of the Testis:

(show top 50) (show all 57)
# Title Authors Year
1
Acute pulmonary hemorrhage associated with metastatic testicular choriocarcinoma in a 46-year-old incarcerated male. ( 30787584 )
2019
2
Testicular choriocarcinoma with cutaneous metastasis in a 19-year-old man. ( 29665032 )
2018
3
Cutaneous and systematic metastasis of testicular choriocarcinoma: Case report and literature review. ( 29851778 )
2018
4
Pure testicular choriocarcinoma presenting as a friable hemorrhagic nodule on the lip. ( 30128343 )
2018
5
Pure Testicular Choriocarcinoma with Dermatological, Brain, and Gastrointestinal Metastases. ( 30324039 )
2018
6
Testicular Choriocarcinoma Metastasizing to the Small Bowel Causing Intussusception: Case Report. ( 30368692 )
2018
7
Pitfalls in Diagnosis and Management of Testicular Choriocarcinoma Metastatic to the Brain: Report of 2 Cases and Review of Literature. ( 28712904 )
2017
8
Metastatic Testicular Choriocarcinoma: A Rare Cause of Upper GI Bleeding. ( 26504875 )
2015
9
Testicular choriocarcinoma metastatic to the stomach: cytological, histological and immunocyto-histochemical findings. ( 24262032 )
2015
10
Pericardial tamponade caused by tumor hemorrhage--a rare complication of metastatic testicular choriocarcinoma. ( 25260397 )
2015
11
Testicular choriocarcinoma: a rare variant that requires a unique treatment approach. ( 25645112 )
2015
12
Choriocarcinoma of the testis. ( 24949806 )
2014
13
Testicular choriocarcinoma presenting as hyperthyroidism. ( 24157290 )
2013
14
Testicular choriocarcinoma: diagnosed on cervical lymph node biopsy. ( 24397105 )
2013
15
A case of gastrointestinal bleeding due to duodenal metastasis from a testicular choriocarcinoma. ( 22961707 )
2013
16
Testicular choriocarcinoma resembling a lipoma. ( 22507580 )
2012
17
Pure choriocarcinoma of the testis presenting with jaundice: a case report and review of the literature. ( 22938171 )
2012
18
Cutaneous metastasis of testicular choriocarcinoma, diagnosed by fine-needle aspiration cytology: a rare case report and review of the literature. ( 23032847 )
2012
19
Choroidal metastasis as the presenting feature in a case of testicular choriocarcinoma. ( 23961001 )
2012
20
Testicular choriocarcinoma: an unusual case of paraneoplastic thyrotoxicosis. ( 21652536 )
2012
21
Choroidal metastases in testicular choriocarcinoma, successful treatment with chemo- and radiotherapy: a case report. ( 22151977 )
2011
22
Cutaneous and systemic metastasis of a testicular choriocarcinoma. ( 20571348 )
2010
23
Image of the month. Upper gastrointestinal bleeding caused by metastatic testicular choriocarcinoma. ( 19447198 )
2010
24
Testicular choriocarcinoma metastatic to skin and multiple organs. Two case reports and review of literature. ( 19469863 )
2010
25
Uveal metastasis from testicular choriocarcinoma presenting as scleritis. ( 19491960 )
2009
26
Improved systemic chemotherapy for metastatic testicular choriocarcinoma can result in excellent prognosis for life and vision. ( 18625957 )
2008
27
Rare gastric metastasis of testicular choriocarcinoma. ( 17521639 )
2007
28
Neck mass as the first presentation of testicular choriocarcinoma. ( 16267684 )
2006
29
Testicular choriocarcinoma metastatic to the skin. ( 16362594 )
2005
30
Testicular choriocarcinoma with gastric metastasis presenting as hematemesis. ( 15627667 )
2004
31
Metastatic uveal tumor secondary to testicular choriocarcinoma. ( 14767663 )
2004
32
Testicular choriocarcinoma metastatic to the skin: an additional case and literature review. ( 11236220 )
2001
33
Testicular choriocarcinoma metastatic to the choroid. ( 10213245 )
1999
34
Image interpretation session: 1997. Metastatic choriocarcinoma of the testis. ( 9460124 )
1998
35
Severe thrombosis after chemotherapy for metastatic choriocarcinoma of the testis maintaining complete remission for a long period. ( 9165594 )
1997
36
Intra-abdominal abscess and tumor-enteric fistula formation: an unusual complication of chemotherapy for advanced testicular choriocarcinoma. ( 8839914 )
1996
37
Metastatic testicular choriocarcinoma of the skin. Report and review of the literature. ( 8989940 )
1996
38
Diastolic runoff with widened arterial pulse pressure in an adolescent with widely metastatic testicular choriocarcinoma. ( 7617511 )
1995
39
Testicular choriocarcinoma revealed by a localized pulmonary edema: a case report. ( 8750131 )
1995
40
The aggressive treatment of choriocarcinoma of the testis associated with lung bone, and brain metastases. ( 7627844 )
1994
41
Metastatic testicular choriocarcinoma and secondary hyperthyroidism: case report and review of the literature. ( 8126794 )
1994
42
Pediatric case of the day. Testicular choriocarcinoma. ( 8498254 )
1993
43
Choriocarcinoma of the testis metastatic to the skin. ( 2030209 )
1991
44
Rapid diagnosis of testicular choriocarcinoma by urinary pregnancy tests. ( 1971080 )
1990
45
Primary testicular choriocarcinoma with pulmonary metastases presenting as ARDS. ( 2331928 )
1990
46
Testicular choriocarcinoma. An unusual presentation as occult gastrointestinal blood loss. ( 2784429 )
1989
47
Hemorrhage: a complication of metastatic testicular choriocarcinoma. ( 3617293 )
1987
48
Chorionic villous-like structures in metastatic testicular choriocarcinoma. ( 3594357 )
1987
49
Metastatic pure choriocarcinoma of the testis in an elderly man. ( 3820391 )
1987
50
Characterization of a human chorionic gonadotropin-producing testicular choriocarcinoma cell line. ( 3820395 )
1987

Variations for Choriocarcinoma of the Testis

Expression for Choriocarcinoma of the Testis

Search GEO for disease gene expression data for Choriocarcinoma of the Testis.

Pathways for Choriocarcinoma of the Testis

Pathways related to Choriocarcinoma of the Testis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.29 CSH1 CSH2 FASLG HLA-G
2
Show member pathways
11.91 FASLG GZMB HLA-G
3 11.4 CDKN2C GZMB MYCN
4 11.19 FASLG GZMB MYCN TIA1
5
Show member pathways
11.11 FASLG GZMB

GO Terms for Choriocarcinoma of the Testis

Biological processes related to Choriocarcinoma of the Testis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to nutrient levels GO:0031667 9.32 CSH1 CSH2
2 positive regulation of JAK-STAT cascade GO:0046427 9.26 CSH1 CSH2
3 animal organ development GO:0048513 9.16 CSH1 CSH2
4 growth hormone receptor signaling pathway GO:0060396 8.96 CSH1 CSH2
5 positive regulation of growth GO:0045927 8.62 CSH1 CSH2

Molecular functions related to Choriocarcinoma of the Testis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth hormone receptor binding GO:0005131 8.62 CSH1 CSH2

Sources for Choriocarcinoma of the Testis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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