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MCID: CHR076
MIFTS: 39

Choriocarcinoma of the Testis

Categories: Cancer diseases, Fetal diseases, Reproductive diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Choriocarcinoma of the Testis

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MalaCards integrated aliases for Choriocarcinoma of the Testis:

Name: Choriocarcinoma of the Testis 12 15 74
Testicular Choriocarcinoma 12 17

Classifications:

MalaCards categories:
Global: Cancer diseases Fetal diseases
Anatomical: Reproductive diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:5551
NCIt 51 C7733
UMLS 74 C0238449
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Summaries for Choriocarcinoma of the Testis

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Disease Ontology : 12 A choriocarcinoma that is located in the testis.

MalaCards based summary : Choriocarcinoma of the Testis, also known as testicular choriocarcinoma, is related to choriocarcinoma and childhood choriocarcinoma of the testis. An important gene associated with Choriocarcinoma of the Testis is CDKN2C (Cyclin Dependent Kinase Inhibitor 2C), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Immune response Role of DAP12 receptors in NK cells. The drugs Paclitaxel and Etoposide have been mentioned in the context of this disorder. Affiliated tissues include testis, bone and bone marrow, and related phenotype is Decreased viability in esophageal squamous lineage.

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Related Diseases for Choriocarcinoma of the Testis

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Diseases related to Choriocarcinoma of the Testis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Related Disease Score Top Affiliating Genes
1 choriocarcinoma 30.8 CSH1 CSH2 HLA-G
2 childhood choriocarcinoma of the testis 12.6
3 testicular monophasic choriocarcinoma 11.2
4 orbit lymphoma 10.3 GZMB TIA1
5 lichen sclerosus et atrophicus 10.3 GZMB TIA1
6 lymphomatoid granulomatosis 10.3 GZMB TIA1
7 viral esophagitis 10.3 GZMB TIA1
8 subcutaneous panniculitis-like t-cell lymphoma 10.3 GZMB TIA1
9 panniculitis 10.3 GZMB TIA1
10 primary cutaneous anaplastic large cell lymphoma 10.2 GZMB TIA1
11 composite lymphoma 10.2 GZMB TIA1
12 hepatosplenic t-cell lymphoma 10.2 GZMB TIA1
13 testicular trophoblastic tumor 10.2 CSH1 CSH2
14 natural killer cell leukemia 10.2 GZMB TIA1
15 choriocarcinoma of ovary 10.2 CSH1 CSH2
16 giardiasis 10.2 GZMB TIA1
17 infiltrating lipoma 10.2 GZMB TIA1
18 non-gestational choriocarcinoma 10.2 CSH1 CSH2
19 gestational trophoblastic neoplasm 10.2 CSH1 CSH2
20 breast medullary carcinoma 10.2 FASLG GZMB
21 angioimmunoblastic t-cell lymphoma 10.2 GZMB TIA1
22 chronic salpingitis 10.1 CSH1 CSH2
23 t-cell large granular lymphocyte leukemia 10.1 FASLG GZMB
24 reticulosarcoma 10.1 GZMB TIA1
25 erythema multiforme 10.1 FASLG GZMB
26 hyperthyroidism 10.1
27 epithelioid trophoblastic tumor 10.0 CSH1 KRT7
28 acute graft versus host disease 10.0 FASLG GZMB
29 papillary transitional carcinoma 10.0 KRT7 PTCRA
30 vulval paget's disease 10.0 KRT7 PTCRA
31 pancreatic serous cystadenoma 10.0 KRT7 PTCRA
32 lymphocytic gastritis 10.0 FASLG GZMB TIA1
33 lymphomatoid papulosis 10.0 FASLG GZMB TIA1
34 vulva adenocarcinoma 10.0 KRT7 PTCRA
35 rh isoimmunization 10.0 AFP CSH1 CSH2
36 b-cell expansion with nfkb and t-cell anergy 10.0 FASLG GZMB TIA1
37 placenta disease 10.0 AFP CSH1 CSH2
38 uterine anomalies 10.0 AFP CSH1 CSH2
39 intrahepatic bile duct adenoma 10.0 AFP KRT7
40 renal pelvis adenocarcinoma 10.0 AFP KRT7
41 ovarian germ cell cancer 10.0 AFP KRT7
42 intratubular embryonal carcinoma 10.0 AFP KRT7
43 thrombosis 9.9
44 bile duct cystadenocarcinoma 9.9 AFP KRT7
45 seminal vesicle tumor 9.9 AFP KRT7
46 adenomatoid tumor 9.9 AFP KRT7
47 intussusception 9.9
48 pulmonary edema 9.9
49 scleritis 9.9
50 ovarian endodermal sinus tumor 9.9 AFP KRT7

Graphical network of the top 20 diseases related to Choriocarcinoma of the Testis:



Diseases related to Choriocarcinoma of the Testis
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Symptoms & Phenotypes for Choriocarcinoma of the Testis

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GenomeRNAi Phenotypes related to Choriocarcinoma of the Testis according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability in esophageal squamous lineage GR00235-A 9.17 AFP CDKN2C FASLG KRT7 MYCN PTCRA
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Drugs & Therapeutics for Choriocarcinoma of the Testis

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Drugs for Choriocarcinoma of the Testis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 96)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Paclitaxel Approved, Vet_approved Phase 2, Phase 3,Phase 3,Phase 1 33069-62-4 36314
2
Etoposide Approved Phase 2, Phase 3,Phase 3 33419-42-0 36462
3
Bleomycin Approved, Investigational Phase 2, Phase 3,Phase 3 11056-06-7 5360373
4
Lenograstim Approved, Investigational Phase 2, Phase 3,Phase 3,Phase 1 135968-09-1
5
Cisplatin Approved Phase 2, Phase 3,Phase 3,Phase 1 15663-27-1 441203 84093 2767
6
Mechlorethamine Approved, Investigational Phase 3,Phase 1,Phase 2 51-75-2 4033
7
Ifosfamide Approved Phase 3,Phase 1,Phase 2 3778-73-2 3690
8
Oxaliplatin Approved, Investigational Phase 3 61825-94-3 6857599 5310940 9887054 43805
9
Carboplatin Approved Phase 3,Phase 2 41575-94-4 38904 10339178 498142
10
Cyclophosphamide Approved, Investigational Phase 3,Phase 2 6055-19-2, 50-18-0 2907
11
Captopril Approved Phase 3 62571-86-2 44093
12
Ribavirin Approved Phase 3 36791-04-5 37542
13
Palivizumab Approved, Investigational Phase 3 188039-54-5
14
Itraconazole Approved, Investigational Phase 3 84625-61-6 55283
15
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
16
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
17
Caspofungin Approved Phase 3 179463-17-3, 162808-62-0 2826718 468682
18
Amphotericin B Approved, Investigational Phase 3 1397-89-3 14956 5280965
19
Vinblastine Approved Phase 3 865-21-4 13342 241903
20 Etoposide phosphate Phase 2, Phase 3,Phase 3
21 Albumin-Bound Paclitaxel Phase 2, Phase 3,Phase 3,Phase 1
22 Anti-Bacterial Agents Phase 2, Phase 3,Phase 3
23 Antibiotics, Antitubercular Phase 2, Phase 3,Phase 3
24 Antimitotic Agents Phase 2, Phase 3,Phase 3,Phase 1
25 Topoisomerase Inhibitors Phase 2, Phase 3,Phase 3
26 Antineoplastic Agents, Phytogenic Phase 2, Phase 3,Phase 3,Phase 1
27
Isophosphamide mustard Phase 3,Phase 1,Phase 2 0
28 Antineoplastic Agents, Alkylating Phase 3,Phase 1,Phase 2
29 Alkylating Agents Phase 3,Phase 1,Phase 2
30 Immunosuppressive Agents Phase 3,Phase 1,Phase 2
31 Immunologic Factors Phase 3,Phase 1,Phase 2
32 Antiviral Agents Phase 3,Phase 1,Phase 2
33 Anti-Infective Agents Phase 3,Phase 1,Phase 2
34 Antimetabolites Phase 3,Phase 1,Phase 2
35 Liver Extracts Phase 3
36 Antirheumatic Agents Phase 3
37 HIV Protease Inhibitors Phase 3
38 Antihypertensive Agents Phase 3
39 Angiotensin-Converting Enzyme Inhibitors Phase 3
40
protease inhibitors Phase 3
41 Antibodies, Monoclonal Phase 3,Phase 1
42 Antibodies Phase 3,Phase 1
43 Immunoglobulins Phase 3,Phase 1
44 Cytochrome P-450 CYP3A Inhibitors Phase 3
45 Cytochrome P-450 CYP2C19 Inhibitors Phase 3
46 Hormone Antagonists Phase 3,Phase 1,Phase 2
47 Cytochrome P-450 Enzyme Inhibitors Phase 3
48 Cytochrome P-450 CYP2C9 Inhibitors Phase 3
49 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 1,Phase 2
50 Steroid Synthesis Inhibitors Phase 3

Interventional clinical trials:

(show all 35)
# Name Status NCT ID Phase Drugs
1 Combination Chemotherapy in Treating Men With Germ Cell Cancer Unknown status NCT00003643 Phase 2, Phase 3 cisplatin;etoposide;paclitaxel
2 Combination Chemotherapy in Treating Patients With Stage II or Stage III Germ Cell Tumors Unknown status NCT00104676 Phase 3 cisplatin;etoposide;ifosfamide;oxaliplatin;paclitaxel
3 Combination Chemotherapy With or Without Peripheral Stem Cell Transplant in Treating Men With Previously Untreated Germ Cell Cancer Completed NCT00003941 Phase 3 cisplatin;etoposide;ifosfamide
4 Combination Chemotherapy With or Without Bone Marrow or Stem Cell Transplantation in Treating Men With Untreated Germ Cell Tumors Completed NCT00002596 Phase 3 carboplatin;cisplatin;cyclophosphamide;etoposide
5 Captopril in Treating Patients Undergoing Bone Marrow or Stem Cell Transplantation Completed NCT00004230 Phase 3 captopril;cyclophosphamide
6 Ribavirin With or Without Monoclonal Antibody Therapy in Treating Patients Who Develop RSV Pneumonia Following Peripheral Stem Cell Transplantation Completed NCT00014391 Phase 3 ribavirin
7 Itraconazole Compared With Fluconazole to Prevent Infections in Patients Undergoing Peripheral Stem Cell or Bone Marrow Transplantation Completed NCT00003883 Phase 3 fluconazole;itraconazole
8 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
9 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3 liposomal amphotericin B
10 Surgery and Combination Chemotherapy in Treating Children With Extracranial Germ Cell Tumors Completed NCT00053352 Phase 3 cisplatin;etoposide
11 Active Surveillance, Bleomycin, Carboplatin, Etoposide, or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors Recruiting NCT03067181 Phase 3 Bleomycin;Carboplatin;Cisplatin;Etoposide;Etoposide Phosphate
12 Cisplatin and Ifosfamide Combined With Either Paclitaxel or Vinblastine in Treating Men With Progressive or Recurrent Metastatic Germ Cell Tumors Terminated NCT00072215 Phase 3 cisplatin;ifosfamide;paclitaxel;vinblastine
13 Gemcitabine, Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Progressive or Relapsed Metastatic Germ Cell Tumors Unknown status NCT00551122 Phase 1, Phase 2 cisplatin;gemcitabine hydrochloride;ifosfamide;paclitaxel
14 Combination Chemotherapy and Pegfilgrastim in Treating Men With Metastatic Germ Cell Tumors Completed NCT00453232 Phase 2 cisplatin;etoposide
15 Combination Chemotherapy and Pegfilgrastim in Treating Patients With Previously Untreated Germ Cell Tumors Completed NCT00470366 Phase 2 cisplatin;ifosfamide;paclitaxel
16 Combination Chemotherapy in Treating Male Patients With Germ Cell Tumors Completed NCT00301782 Phase 2 carboplatin;cisplatin;etoposide phosphate;vincristine sulfate
17 Sunitinib in Treating Patients With Metastatic Germ Cell Tumors That Have Relapsed or Not Responded to Treatment Completed NCT00453310 Phase 2 sunitinib malate
18 Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Relapsed Germ Cell Cancer Completed NCT00002931 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel
19 Immunotherapy in Treating Patients Who Are Undergoing Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00002673 Phase 2
20 Lymphocyte Infusion in Treating Patients With Relapsed Cancer After Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00003887 Phase 2
21 Beclomethasone in Treating Patients With Graft-Versus-Host Disease of the Esophagus, Stomach, Small Intestine, or Colon Completed NCT00010283 Phase 1, Phase 2 beclomethasone dipropionate
22 Interleukin-11 Plus Filgrastim Prior to Peripheral Stem Cell Transplantation in Patients With Non-Hodgkin's Lymphoma, Hodgkin's Disease, Breast Cancer, or Other Solid Tumors Completed NCT00004157 Phase 2
23 Ixabepilone in Treating Patients With Advanced Cisplatin-Refractory Germ Cell Tumors Completed NCT00070096 Phase 2 ixabepilone
24 Biological Therapy Following Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Cancer Completed NCT00003408 Phase 2
25 Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Metastatic Testicular Cancer Completed NCT00004077 Phase 2 cisplatin;ifosfamide;paclitaxel
26 Combination Chemotherapy in Treating Young Patients With Recurrent or Resistant Malignant Germ Cell Tumors Completed NCT00467051 Phase 2 Carboplatin;Ifosfamide;Paclitaxel
27 Autologous Peripheral Blood Stem Cell Transplant for Germ Cell Tumors Recruiting NCT00432094 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel;thiotepa;Mesna
28 Role of Axumin PET Scan in Germ Cell Tumor Recruiting NCT03426865 Phase 2 Axumin PET scan
29 Ipilimumab After Allogeneic Stem Cell Transplant in Treating Patients With Persistent or Progressive Cancer Completed NCT00060372 Phase 1 ipilimumab;therapeutic allogeneic lymphocytes
30 Interleukin-12 in Treating Patients With Hematologic Cancers or Solid Tumors Completed NCT00003107 Phase 1
31 Positron Emission Tomography in Detecting Testicle Cancer Completed NCT00045045 Not Applicable
32 Acupuncture in Treating Mucositis-Related Pain Caused by Chemotherapy in Patients Undergoing Stem Cell Transplantation Completed NCT00060021 Not Applicable
33 Standard Follow-up Compared With Extended Follow-up in Treating Patients Who Have Undergone Stem Cell Transplantation for Cancer Completed NCT00049465 Not Applicable
34 Diagnostic Study of Patients With Stage I Testicular Cancer Completed NCT00003800 Not Applicable
35 DNA Analysis in Samples From Younger Patients With Germ Cell Tumors and Their Parents or Siblings Completed NCT01434355

Search NIH Clinical Center for Choriocarcinoma of the Testis

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Genetic Tests for Choriocarcinoma of the Testis

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Anatomical Context for Choriocarcinoma of the Testis

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MalaCards organs/tissues related to Choriocarcinoma of the Testis:

42
Testis, Bone, Bone Marrow, Liver, Colon, Breast, Small Intestine

The Foundational Model of Anatomy Ontology organs/tissues related to Choriocarcinoma of the Testis:

20
The Testis
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Publications for Choriocarcinoma of the Testis

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Articles related to Choriocarcinoma of the Testis:

(show all 33)
# Title Authors Year
1
Acute pulmonary hemorrhage associated with metastatic testicular choriocarcinoma in a 46-year-old incarcerated male. ( 30787584 )
2019
2
Pure testicular choriocarcinoma presenting as a friable hemorrhagic nodule on the lip. ( 30128343 )
2018
3
Pure Testicular Choriocarcinoma with Dermatological, Brain, and Gastrointestinal Metastases. ( 30324039 )
2018
4
Testicular Choriocarcinoma Metastasizing to the Small Bowel Causing Intussusception: Case Report. ( 30368692 )
2018
5
Choriocarcinoma of the testis. ( 24949806 )
2014
6
Pure choriocarcinoma of the testis presenting with jaundice: a case report and review of the literature. ( 22938171 )
2012
7
Metastatic uveal tumor secondary to testicular choriocarcinoma. ( 14767663 )
2004
8
Testicular choriocarcinoma with gastric metastasis presenting as hematemesis. ( 15627667 )
2004
9
Testicular choriocarcinoma metastatic to the choroid. ( 10213245 )
1999
10
Image interpretation session: 1997. Metastatic choriocarcinoma of the testis. ( 9460124 )
1998
11
Severe thrombosis after chemotherapy for metastatic choriocarcinoma of the testis maintaining complete remission for a long period. ( 9165594 )
1997
12
Intra-abdominal abscess and tumor-enteric fistula formation: an unusual complication of chemotherapy for advanced testicular choriocarcinoma. ( 8839914 )
1996
13
Metastatic testicular choriocarcinoma of the skin. Report and review of the literature. ( 8989940 )
1996
14
Diastolic runoff with widened arterial pulse pressure in an adolescent with widely metastatic testicular choriocarcinoma. ( 7617511 )
1995
15
Testicular choriocarcinoma revealed by a localized pulmonary edema: a case report. ( 8750131 )
1995
16
The aggressive treatment of choriocarcinoma of the testis associated with lung bone, and brain metastases. ( 7627844 )
1994
17
Metastatic testicular choriocarcinoma and secondary hyperthyroidism: case report and review of the literature. ( 8126794 )
1994
18
Pediatric case of the day. Testicular choriocarcinoma. ( 8498254 )
1993
19
Choriocarcinoma of the testis metastatic to the skin. ( 2030209 )
1991
20
Rapid diagnosis of testicular choriocarcinoma by urinary pregnancy tests. ( 1971080 )
1990
21
Primary testicular choriocarcinoma with pulmonary metastases presenting as ARDS. ( 2331928 )
1990
22
Testicular choriocarcinoma. An unusual presentation as occult gastrointestinal blood loss. ( 2784429 )
1989
23
Metastatic pure choriocarcinoma of the testis in an elderly man. ( 3820391 )
1987
24
Chorionic villous-like structures in metastatic testicular choriocarcinoma. ( 3594357 )
1987
25
Hemorrhage: a complication of metastatic testicular choriocarcinoma. ( 3617293 )
1987
26
Characterization of a human chorionic gonadotropin-producing testicular choriocarcinoma cell line. ( 3820395 )
1987
27
Testicular choriocarcinoma with metastasis to gastric mucosa. ( 6539722 )
1984
28
Stage C pure choriocarcinoma of the testis: a potentially curable lesion. ( 6800592 )
1982
29
Choriocarcinoma of the testis. ( 4134907 )
1974
30
Choriocarcinoma of the testis: case report with review of the literature. ( 4533449 )
1973
31
Testicular choriocarcinoma in LSD users. Coincidence or cause? ( 5109040 )
1971
32
Choriocarcinoma of the testis. ( 4174513 )
1968
33
Choriocarcinoma of the testis and extragenital choriocarcinoma in men. ( 13825140 )
1959
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Variations for Choriocarcinoma of the Testis

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Expression for Choriocarcinoma of the Testis

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Search GEO for disease gene expression data for Choriocarcinoma of the Testis.
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Pathways for Choriocarcinoma of the Testis

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Pathways related to Choriocarcinoma of the Testis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
PI3K-Akt signaling pathway 38
Show member pathways
 12.29 CSH1 CSH2 FASLG HLA-G
2
Immune response Role of DAP12 receptors in NK cells 23
Show member pathways
 11.91 FASLG GZMB HLA-G
3
Transcriptional misregulation in cancer 38
11.53 CDKN2C GZMB MYCN PTCRA
4
Apoptosis and Autophagy 4
11.19 FASLG GZMB MYCN TIA1
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GO Terms for Choriocarcinoma of the Testis

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Biological processes related to Choriocarcinoma of the Testis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of JAK-STAT cascade GO:0046427 9.26 CSH1 CSH2
2 animal organ development GO:0048513 9.16 CSH1 CSH2
3 growth hormone receptor signaling pathway GO:0060396 8.96 CSH1 CSH2
4 positive regulation of growth GO:0045927 8.62 CSH1 CSH2

Molecular functions related to Choriocarcinoma of the Testis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth hormone receptor binding GO:0005131 8.62 CSH1 CSH2
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Sources for Choriocarcinoma of the Testis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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