MCID: CHR076
MIFTS: 33

Choriocarcinoma of the Testis

Categories: Cancer diseases, Fetal diseases, Reproductive diseases

Aliases & Classifications for Choriocarcinoma of the Testis

MalaCards integrated aliases for Choriocarcinoma of the Testis:

Name: Choriocarcinoma of the Testis 12 15 71
Testicular Choriocarcinoma 12 17

Classifications:



External Ids:

Disease Ontology 12 DOID:5551
NCIt 49 C7733
UMLS 71 C0238449

Summaries for Choriocarcinoma of the Testis

Disease Ontology : 12 A choriocarcinoma that is located in the testis.

MalaCards based summary : Choriocarcinoma of the Testis, also known as testicular choriocarcinoma, is related to choriocarcinoma and mature teratoma. An important gene associated with Choriocarcinoma of the Testis is AFP (Alpha Fetoprotein). The drugs Lenograstim and Carboplatin have been mentioned in the context of this disorder. Affiliated tissues include testis, bone and bone marrow.

Related Diseases for Choriocarcinoma of the Testis

Diseases related to Choriocarcinoma of the Testis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 70)
# Related Disease Score Top Affiliating Genes
1 choriocarcinoma 30.4 CSH2 CSH1
2 mature teratoma 29.9 SALL4 AFP
3 childhood choriocarcinoma of the testis 12.7
4 testicular monophasic choriocarcinoma 11.3
5 germ cells tumors 10.5
6 mixed germ cell tumor 10.3
7 testicular germ cell tumor 10.2
8 testicular germ cell cancer 10.2
9 extragonadal seminoma 10.1 SALL4 AFP
10 ovarian endodermal sinus tumor 10.1 SALL4 AFP
11 endodermal sinus tumor 10.1 SALL4 AFP
12 juvenile type testicular granulosa cell tumor 10.1 INTS13 AFP
13 ovarian primitive germ cell tumor 10.1 SALL4 AFP
14 testicular granulosa cell tumor 10.1 INTS13 AFP
15 childhood endodermal sinus tumor 10.1 SALL4 AFP
16 testicular cancer 10.1
17 testicular malignant germ cell cancer 10.1 SALL4 AFP
18 graves disease 1 10.1
19 active peptic ulcer disease 10.1
20 hyperthyroidism 10.1
21 germ cell cancer 10.1 SALL4 AFP
22 mixed germ cell cancer 10.1 SALL4 AFP
23 central nervous system germ cell tumor 10.1 SALL4 AFP
24 spermatocytoma 10.1 SALL4 AFP
25 ovarian germ cell cancer 10.0 SALL4 AFP
26 hepatoid adenocarcinoma 10.0 SALL4 AFP
27 malignant teratoma 10.0 SALL4 AFP
28 thrombophilia due to thrombin defect 10.0
29 infant gynecomastia 10.0
30 gynecomastia 10.0
31 cholestasis 10.0
32 obstructive jaundice 10.0
33 teratoma 10.0
34 hydrocele 10.0
35 intussusception 9.9
36 lipomatosis, multiple 9.9
37 retinal detachment 9.9
38 triiodothyronine receptor auxiliary protein 9.9
39 pleomorphic lipoma 9.9
40 hydronephrosis 9.9
41 arteriovenous malformation 9.9
42 pulmonary edema 9.9
43 acute leukemia 9.9
44 scleritis 9.9
45 embryonal carcinoma 9.9
46 pulmonary embolism 9.9
47 nonseminomatous germ cell tumor 9.9
48 tetraploidy 9.9
49 dysgerminoma 9.9 SALL4 AFP
50 anencephaly 9.8 FOLR1 AFP

Graphical network of the top 20 diseases related to Choriocarcinoma of the Testis:



Diseases related to Choriocarcinoma of the Testis

Symptoms & Phenotypes for Choriocarcinoma of the Testis

Drugs & Therapeutics for Choriocarcinoma of the Testis

Drugs for Choriocarcinoma of the Testis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 85)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lenograstim Approved, Investigational Phase 3 135968-09-1
2
Carboplatin Approved Phase 3 41575-94-4 10339178 38904 498142
3
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
4
Captopril Approved Phase 3 62571-86-2 44093
5
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
6
Clotrimazole Approved, Vet_approved Phase 3 23593-75-1 2812
7
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
8
Itraconazole Approved, Investigational Phase 3 84625-61-6 55283
9
Ribavirin Approved Phase 3 36791-04-5 37542
10
Palivizumab Approved, Investigational Phase 3 188039-54-5
11
Amphotericin B Approved, Investigational Phase 3 1397-89-3 5280965 14956
12
Caspofungin Approved Phase 3 162808-62-0, 179463-17-3 2826718 468682
13
Bleomycin Approved, Investigational Phase 3 11056-06-7 5360373
14
Etoposide Approved Phase 3 33419-42-0 36462
15
Oxaliplatin Approved, Investigational Phase 3 61825-94-3 43805 6857599 5310940 9887054
16
Cisplatin Approved Phase 3 15663-27-1 2767 441203 84093
17
Paclitaxel Approved, Vet_approved Phase 3 33069-62-4 36314
18
Ifosfamide Approved Phase 3 3778-73-2 3690
19
Vinblastine Approved Phase 3 865-21-4 241903 13342
20 Liver Extracts Phase 3
21 Immunologic Factors Phase 3
22 Immunosuppressive Agents Phase 3
23 Antihypertensive Agents Phase 3
24 Angiotensin-Converting Enzyme Inhibitors Phase 3
25 HIV Protease Inhibitors Phase 3
26
protease inhibitors Phase 3
27 Antirheumatic Agents Phase 3
28 Cytochrome P-450 Enzyme Inhibitors Phase 3
29 Anti-Infective Agents Phase 3
30 Hormone Antagonists Phase 3
31 Hormones Phase 3
32
Hydroxyitraconazole Phase 3
33 Antifungal Agents Phase 3
34 Cytochrome P-450 CYP3A Inhibitors Phase 3
35 Immunoglobulins Phase 3
36 Antibodies Phase 3
37 Antiviral Agents Phase 3
38 Antibodies, Monoclonal Phase 3
39 Antimetabolites Phase 3
40 Amebicides Phase 3
41 Antiparasitic Agents Phase 3
42 Antiprotozoal Agents Phase 3
43 Liposomal amphotericin B Phase 3
44 Etoposide phosphate Phase 3
45 Anti-Bacterial Agents Phase 3
46 Antibiotics, Antitubercular Phase 3
47 Albumin-Bound Paclitaxel Phase 3
48
Isophosphamide mustard Phase 3 0
49 Alkylating Agents Phase 3
50 Tubulin Modulators Phase 3

Interventional clinical trials:

(show all 29)
# Name Status NCT ID Phase Drugs
1 Randomized Phase II/III Study of Taxol/Paclitaxel-BEP Versus BEP in Patients With Intermediate Prognosis Germ Cell Cancer Unknown status NCT00003643 Phase 2, Phase 3 cisplatin;etoposide;paclitaxel
2 A Randomized Phase III Study of Sequential High-Dose Cisplatinum/Etoposide/Ifosfamide Plus Stem Cell Support Versus BEP in Patients With Poor Prognosis Germ Cell Cancer Completed NCT00003941 Phase 3 cisplatin;etoposide;ifosfamide
3 Phase III Study of Captopril in Patients Undergoing Autologous Bone Marrow/Stem Cell Transplantation Completed NCT00004230 Phase 3 captopril;cyclophosphamide
4 A Randomized, Comparative Study of Itraconazole Versus Fluconazole for Prevention of Aspergillus Infections in Peripheral Blood Stem Cell and Marrow Transplant Recipients Completed NCT00003883 Phase 3 fluconazole;itraconazole
5 A Randomized Double-Blind Placebo-Controlled Phase III Study To Evaluate The Safety And Efficacy Of Palivizumab Combined With Aerosolized Ribavirin Compared To Ribavirin Alone To Treat RSV Pneumonia In Patients With Bone Marrow Transplants (BMT) Completed NCT00014391 Phase 3 ribavirin
6 RANDOMIZED MULTIINSTITUTIONAL PHASE III TRIAL OF BEP AND HIGH DOSE CHEMOTHERAPY VERSUS BEP ALONE IN PREVIOUSLY UNTREATED PATIENTS WITH POOR RISK GERM CELL TUMORS Completed NCT00002596 Phase 3 carboplatin;cisplatin;cyclophosphamide;etoposide
7 A Strategic Study to Determine the Optimal Moment to Initiate Systemic Antifungal Therapy With Ambisome in Granulocytopenic Cancer Patients With Unexplained Fever Refractory to Empirical Antibacterials Completed NCT00003938 Phase 3 liposomal amphotericin B
8 A Multicenter, Double-Blind, Randomized, Comparative Study To Evaluate The Safety, Tolerability, And Efficacy Of MK-0991 Versus (Amphotericin B) Liposome For Injection As Empirical Therapy In Patients With Persistent Fever And Neutropenia Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
9 A Risk-Adapted Strategy of the Use of Dose-Dense Chemotherapy in Patients With Poor-Prognosis Disseminated Non-Seminomatous Germ Cell Tumors Active, not recruiting NCT00104676 Phase 3 cisplatin;etoposide;ifosfamide;oxaliplatin;paclitaxel
10 A Randomized Phase III Study of Paclitaxel, Ifosfamide and Cisplatin Versus Vinblastine, Ifosfamide and Cisplatin as Second-Line Therapy for Patients With Relapsed/Resistant Germ Cell Tumors Terminated NCT00072215 Phase 3 cisplatin;ifosfamide;paclitaxel;vinblastine
11 Phase I/II Multicentre Trial of Salvage Chemotherapy With Gem-TIP for Relapsed Germ Cell Cancer Unknown status NCT00551122 Phase 1, Phase 2 cisplatin;gemcitabine hydrochloride;ifosfamide;paclitaxel
12 A Phase II Study of BMS-247550 In Advanced Germ Cell Tumor Patients - THERAPEUTIC/DIAGNOSTIC PROTOCOL Completed NCT00070096 Phase 2 ixabepilone
13 A Study of Paclitaxel, Cisplatin and Ifosfamide as Induction Therapy in the Treatment of Patients Relapsing After BEP Chemotherapy for Metastatic Germ Cell Tumors Completed NCT00004077 Phase 2 cisplatin;ifosfamide;paclitaxel
14 A Phase II Study of Sunitinib in Patients With Refractory or Relapsed Germ Cell Tumors Completed NCT00453310 Phase 2 sunitinib malate
15 Accelerated BEP Chemotherapy for Intermediate and High Risk Metastatic Germ Cell Tumor Completed NCT00453232 Phase 2 cisplatin;etoposide
16 Tandem High-Dose Chemotherapy With Autologous Stem Cell Rescue for Poor-Prognosis Germ Cell Cancer Completed NCT00002931 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel
17 Phase II Trial of Paclitaxel, Ifosfamide, and Cisplatin in Previously Untreated Intermediate and Poor Risk Germ Cell Tumor Patients Completed NCT00470366 Phase 2 cisplatin;ifosfamide;paclitaxel
18 Randomized Phase II Trial of Intensive Induction Chemotherapy (CBOP/BEP) and Standard BEP Chemotherapy in Poor Prognosis Male Germ Cell Tumors Completed NCT00301782 Phase 2 carboplatin;cisplatin;etoposide phosphate;vincristine sulfate
19 Combination of Interleukin 11 (Neumega) With G-CSF to Mobilize Autologous Peripheral Blood Stem Cells (PBSC) Completed NCT00004157 Phase 2
20 Donor Lymphocyte Infusion (DLI) as Adoptive Immunotherapy for Relapse Malignancies After Allogeneic Hematopoietic Transplantation Completed NCT00003887 Phase 2
21 Oral Beclomethasone Dipropionate Capsules for Treatment of Intestinal Graft-Versus-Host Disease: Compassionate Use in Patients With Contraindictions to High-Dose Immunosuppressive Therapy Completed NCT00010283 Phase 1, Phase 2 beclomethasone dipropionate
22 Cytokine-Based Immunotherapy Following High-Dose Chemotherapy and Autologous Stem Cell Transplantation Completed NCT00003408 Phase 2
23 A PHASE II STUDY OF CELLULAR ADOPTIVE IMMUNOTHERAPY AS PROPHYLAXIS FOR CYTOMEGALOVIRUS DISEASE AFTER ALLOGENEIC BONE MARROW TRANSPLANTATION Completed NCT00002673 Phase 2
24 Autologous Peripheral Blood Stem Cell Transplant for Germ Cell Tumors Recruiting NCT00432094 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel;thiotepa;Mesna
25 A Phase I Trial of Recombinant Human Interleukin-12 After High-Dose Therapy and Autologous Hematopoietic Stem Cell Support Completed NCT00003107 Phase 1
26 A Study Of 18 FDG PET In The Prediction Of Relapse In Patients With A Clinical Stage I Non-Seminomatous Germ Cell Tumor Completed NCT00045045
27 Correlation of Histopathology, Immunohistochemistry and Quantitative Radiology With Outcome in Early Stage Nonseminomatous Germ Cell Tumor Completed NCT00003800
28 A Randomized, Placebo-Controlled, Blinded Study Of Acupuncture Therapy In Mucositis-Related Pain In Patients Undergoing Hematopoietic Stem Cell Transplantation Completed NCT00060021
29 Multi-Site Randomized Clinical Trial Comparing Standard Recovery Preparation to Extended Recovery Preparation to Enhance Long Term Function After Marrow or Stem Cell Transplant Completed NCT00049465

Search NIH Clinical Center for Choriocarcinoma of the Testis

Genetic Tests for Choriocarcinoma of the Testis

Anatomical Context for Choriocarcinoma of the Testis

The Foundational Model of Anatomy Ontology organs/tissues related to Choriocarcinoma of the Testis:

19
Testis

MalaCards organs/tissues related to Choriocarcinoma of the Testis:

40
Testis, Bone, Bone Marrow, Liver, Skin, Brain, Lung

Publications for Choriocarcinoma of the Testis

Articles related to Choriocarcinoma of the Testis:

(show top 50) (show all 110)
# Title Authors PMID Year
1
Frequent EGFR expression/EGFR amplification and lack of activating mutation in testicular choriocarcinoma. 61
31994813 2020
2
Gastrointestinal Bleeding with Hemodynamic Repercussion due to a Gastric Metastatic Lesion of a Testicular Choriocarcinoma in a Previously Asymptomatic Young Adult. 61
32509930 2020
3
Head and neck cutaneous metastasis of testicular choriocarcinoma. 61
32102892 2020
4
Bilateral wunderlich syndrome secondary to synchronous bilateral testicular germ cell tumor. A case report. 61
31641608 2020
5
Testicular Choriocarcinoma Metastasizing to the Small Bowel Causing Intussusception: Case Report. 61
30368692 2019
6
Metastatic Testicular Choriocarcinoma: An Unusual Cause of Upper Gastrointestinal Bleed. 61
31565641 2019
7
Cutaneous Metastasis of Choriocarcinoma in 2 Male Patients: A Rare Presentation of an Aggressive Malignancy That Dermatopathologists Must Recognize. 61
29944473 2019
8
Acute pulmonary hemorrhage associated with metastatic testicular choriocarcinoma in a 46-year-old incarcerated male. 61
30787584 2019
9
Pure testicular choriocarcinoma presenting as a friable hemorrhagic nodule on the lip. 61
30128343 2018
10
Pure Testicular Choriocarcinoma with Dermatological, Brain, and Gastrointestinal Metastases. 61
30324039 2018
11
Testicular choriocarcinoma with cutaneous metastasis in a 19-year-old man. 61
29665032 2018
12
Cutaneous and systematic metastasis of testicular choriocarcinoma: Case report and literature review. 61
29851778 2018
13
Spontaneous renal hemorrhage secondary to choriocarcinoma in a man with congenital hypospadias and cryptorchidism: a case report and literature review. 61
29739453 2018
14
Pitfalls in Diagnosis and Management of Testicular Choriocarcinoma Metastatic to the Brain: Report of 2 Cases and Review of Literature. 61
28712904 2017
15
Metastatic choriocarcinoma induced separate simultaneous intracerebral haemorrhages: a very rare occurrence and its novel association with Klinefelter syndrome. 61
26564116 2015
16
Hemorrhagic collision metastasis in a cerebral arteriovenous malformation. 61
25261441 2015
17
Metastatic Testicular Choriocarcinoma: A Rare Cause of Upper GI Bleeding. 61
26504875 2015
18
Pericardial tamponade caused by tumor hemorrhage--a rare complication of metastatic testicular choriocarcinoma. 61
25260397 2015
19
Testicular choriocarcinoma metastatic to the stomach: cytological, histological and immunocyto-histochemical findings. 61
24262032 2015
20
Testicular choriocarcinoma: a rare variant that requires a unique treatment approach. 61
25645112 2015
21
A Literature Review and Case Report of Metastatic Pure Choriocarcinoma. 61
26649213 2015
22
Hemorrhagic collision metastasis in a cerebral arteriovenous malformation. 61
25239982 2014
23
Choriocarcinoma of the testis. 61
24949806 2014
24
HLA-G in testicular germ cell tumors. 61
24853783 2014
25
Testicular choriocarcinoma: diagnosed on cervical lymph node biopsy. 61
24397105 2013
26
Testicular choriocarcinoma presenting as hyperthyroidism. 61
24157290 2013
27
A case of gastrointestinal bleeding due to duodenal metastasis from a testicular choriocarcinoma. 61
22961707 2013
28
[Hemoptysis revealing an endobronchial metastasis of testicular choriocarcinoma]. 61
23318195 2013
29
Pure choriocarcinoma of the testis presenting with jaundice: a case report and review of the literature. 61
22938171 2012
30
Testicular choriocarcinoma: an unusual case of paraneoplastic thyrotoxicosis. 61
21652536 2012
31
Cutaneous metastasis of testicular choriocarcinoma, diagnosed by fine-needle aspiration cytology: a rare case report and review of the literature. 61
23032847 2012
32
Testicular choriocarcinoma resembling a lipoma. 61
22507580 2012
33
Choroidal metastasis as the presenting feature in a case of testicular choriocarcinoma. 61
23961001 2012
34
Choroidal metastases in testicular choriocarcinoma, successful treatment with chemo- and radiotherapy: a case report. 61
22151977 2011
35
Cutaneous and systemic metastasis of a testicular choriocarcinoma. 61
20571348 2010
36
Testicular choriocarcinoma metastatic to skin and multiple organs. Two case reports and review of literature. 61
19469863 2010
37
Image of the month. Upper gastrointestinal bleeding caused by metastatic testicular choriocarcinoma. 61
19447198 2010
38
Uncommon mucosal metastases to the stomach. 61
19650900 2009
39
Uveal metastasis from testicular choriocarcinoma presenting as scleritis. 61
19491960 2009
40
[Case of metastatic germ cell tumor with testicular calcification detected by MD-CT]. 61
18939415 2008
41
Improved systemic chemotherapy for metastatic testicular choriocarcinoma can result in excellent prognosis for life and vision. 61
18625957 2008
42
Testicular carcinoma presenting as cutaneous nasal metastasis: case report and review of the literature. 61
18155815 2008
43
[Jejunal perforation from metastatic choriocarcinoma. Case report and review of the literature]. 61
18419977 2008
44
Rare gastric metastasis of testicular choriocarcinoma. 61
17521639 2007
45
[Testicular choriocarcinoma with pure histological pattern. Necropsy study in a representative case]. 61
17601304 2007
46
Pure choriocarcinoma of testis with rare gingival and skin metastases. 61
17342276 2007
47
Pure choriocarcinoma of testis with tumor-infiltrating lymphocytes and granulomas. 61
17191322 2006
48
An unusual presentation of testicular tumor. 61
17125642 2006
49
Neck mass as the first presentation of testicular choriocarcinoma. 61
16267684 2006
50
[Testicular choriocarcinoma presenting as cutaneous metastasis. A case report and review of the literature]. 61
15963845 2005

Variations for Choriocarcinoma of the Testis

Expression for Choriocarcinoma of the Testis

Search GEO for disease gene expression data for Choriocarcinoma of the Testis.

Pathways for Choriocarcinoma of the Testis

GO Terms for Choriocarcinoma of the Testis

Biological processes related to Choriocarcinoma of the Testis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.4 CSH2 CSH1
2 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.37 CSH2 CSH1
3 response to nutrient levels GO:0031667 9.32 CSH2 CSH1
4 positive regulation of JAK-STAT cascade GO:0046427 9.26 CSH2 CSH1
5 animal organ development GO:0048513 9.16 CSH2 CSH1
6 growth hormone receptor signaling pathway GO:0060396 8.96 CSH2 CSH1
7 positive regulation of growth GO:0045927 8.62 CSH2 CSH1

Molecular functions related to Choriocarcinoma of the Testis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.96 CSH2 CSH1
2 growth hormone receptor binding GO:0005131 8.62 CSH2 CSH1

Sources for Choriocarcinoma of the Testis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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