MCID: CHR076
MIFTS: 33

Choriocarcinoma of the Testis

Categories: Cancer diseases, Reproductive diseases, Fetal diseases

Aliases & Classifications for Choriocarcinoma of the Testis

MalaCards integrated aliases for Choriocarcinoma of the Testis:

Name: Choriocarcinoma of the Testis 12 15 73
Testicular Choriocarcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5551
NCIt 50 C7733
SNOMED-CT 68 147371000119101
UMLS 73 C0238449

Summaries for Choriocarcinoma of the Testis

MalaCards based summary : Choriocarcinoma of the Testis, also known as testicular choriocarcinoma, is related to choriocarcinoma and childhood choriocarcinoma of the testis. An important gene associated with Choriocarcinoma of the Testis is CDKN2C (Cyclin Dependent Kinase Inhibitor 2C), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Regulation of IFNA signaling. The drugs Lenograstim and Etoposide have been mentioned in the context of this disorder. Affiliated tissues include testis, bone and bone marrow, and related phenotype is Decreased viability in esophageal squamous lineage.

Related Diseases for Choriocarcinoma of the Testis

Diseases related to Choriocarcinoma of the Testis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Related Disease Score Top Affiliating Genes
1 choriocarcinoma 30.7 CSH1 CSH2 HLA-G
2 childhood choriocarcinoma of the testis 12.2
3 orbit lymphoma 10.5 GZMB TIA1
4 lichen sclerosus et atrophicus 10.5 GZMB TIA1
5 lymphomatoid granulomatosis 10.5 GZMB TIA1
6 viral esophagitis 10.5 GZMB TIA1
7 subcutaneous panniculitis-like t-cell lymphoma 10.5 GZMB TIA1
8 primary cutaneous anaplastic large cell lymphoma 10.5 GZMB TIA1
9 testicular trophoblastic tumor 10.5 CSH1 CSH2
10 natural killer cell leukemia 10.5 GZMB TIA1
11 composite lymphoma 10.5 GZMB TIA1
12 hepatosplenic t-cell lymphoma 10.5 GZMB TIA1
13 choriocarcinoma of ovary 10.4 CSH1 CSH2
14 giardiasis 10.4 GZMB TIA1
15 non-gestational choriocarcinoma 10.4 CSH1 CSH2
16 infiltrating lipoma 10.4 GZMB TIA1
17 gestational trophoblastic neoplasm 10.4 CSH1 CSH2
18 breast medullary carcinoma 10.3 FASLG GZMB
19 panniculitis 10.3 GZMB TIA1
20 chronic salpingitis 10.3 CSH1 CSH2
21 t-cell large granular lymphocyte leukemia 10.2 FASLG GZMB
22 erythema multiforme 10.1 FASLG GZMB
23 reticulosarcoma 10.1 GZMB TIA1
24 epithelioid trophoblastic tumor 10.1 CSH1 KRT7
25 sialolithiasis 10.0 FASLG GZMB
26 vulval paget's disease 10.0 KRT7 PTCRA
27 intrahepatic bile duct adenoma 10.0 AFP KRT7
28 testicular granulosa cell tumor 10.0 AFP CSH1 CSH2
29 juvenile type testicular granulosa cell tumor 10.0 AFP CSH1 CSH2
30 rh isoimmunization 10.0 AFP CSH1 CSH2
31 uterine anomalies 10.0 AFP CSH1 CSH2
32 pancreatic serous cystadenoma 10.0 KRT7 PTCRA
33 renal pelvis adenocarcinoma 10.0 AFP KRT7
34 acute graft versus host disease 10.0 FASLG GZMB
35 placenta disease 10.0 AFP CSH1 CSH2
36 ovarian germ cell cancer 10.0 AFP KRT7
37 vulva adenocarcinoma 10.0 KRT7 PTCRA
38 bile duct cystadenocarcinoma 10.0 AFP KRT7
39 intratubular embryonal carcinoma 10.0 AFP KRT7
40 female reproductive system disease 9.9 CSH1 CSH2
41 lymphocytic gastritis 9.9 FASLG GZMB TIA1
42 adenomatoid tumor 9.9 AFP KRT7
43 lymphomatoid papulosis 9.9 FASLG GZMB TIA1
44 seminal vesicle tumor 9.9 AFP KRT7
45 sertoli-leydig cell tumor 9.9 AFP KRT7
46 b-cell expansion with nfkb and t-cell anergy 9.9 FASLG GZMB TIA1
47 malignant biphasic mesothelioma 9.9 AFP KRT7
48 ovarian endodermal sinus tumor 9.9 AFP KRT7
49 ovarian primitive germ cell tumor 9.9 AFP KRT7
50 cystadenofibroma 9.8 AFP KRT7

Graphical network of the top 20 diseases related to Choriocarcinoma of the Testis:



Diseases related to Choriocarcinoma of the Testis

Symptoms & Phenotypes for Choriocarcinoma of the Testis

GenomeRNAi Phenotypes related to Choriocarcinoma of the Testis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability in esophageal squamous lineage GR00235-A 9.17 PTCRA TIA1 AFP CDKN2C FASLG KRT7

Drugs & Therapeutics for Choriocarcinoma of the Testis

Drugs for Choriocarcinoma of the Testis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 91)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lenograstim Approved, Investigational Phase 2, Phase 3,Phase 3,Phase 1 135968-09-1
2
Etoposide Approved Phase 2, Phase 3,Phase 3 33419-42-0 36462
3
Cisplatin Approved Phase 2, Phase 3,Phase 3,Phase 1 15663-27-1 84093 441203 2767
4
Mechlorethamine Approved, Investigational Phase 3,Phase 1,Phase 2 51-75-2 4033
5
Ifosfamide Approved Phase 3,Phase 1,Phase 2 3778-73-2 3690
6
Oxaliplatin Approved, Investigational Phase 3 61825-94-3 5310940 9887054 43805 6857599
7
Paclitaxel Approved, Vet_approved Phase 2, Phase 3,Phase 3,Phase 1 33069-62-4 36314
8
Bleomycin Approved, Investigational Phase 2, Phase 3,Phase 3 11056-06-7 5360373
9
Ribavirin Approved Phase 3 36791-04-5 37542
10
Carboplatin Approved Phase 3,Phase 2 41575-94-4 10339178 498142 38904
11
Captopril Approved Phase 3 62571-86-2 44093
12
Amphotericin B Approved, Investigational Phase 3 1397-89-3 14956 5280965
13
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
14
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
15
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
16
Itraconazole Approved, Investigational Phase 3 84625-61-6 55283
17
Palivizumab Approved, Investigational Phase 3 188039-54-5
18
Caspofungin Approved Phase 3 179463-17-3, 162808-62-0 468682 2826718
19
Vinblastine Approved Phase 3 865-21-4 13342 241903
20
Isophosphamide mustard Phase 3,Phase 1,Phase 2 0
21 Alkylating Agents Phase 3,Phase 1,Phase 2
22 Albumin-Bound Paclitaxel Phase 2, Phase 3,Phase 3,Phase 1
23 Topoisomerase Inhibitors Phase 2, Phase 3,Phase 3
24 Anti-Bacterial Agents Phase 2, Phase 3,Phase 3
25 Antibiotics, Antitubercular Phase 2, Phase 3,Phase 3
26 Etoposide phosphate Phase 2, Phase 3,Phase 3
27 Immunosuppressive Agents Phase 3,Phase 1,Phase 2
28 Anti-Infective Agents Phase 3,Phase 1,Phase 2
29 Antimetabolites Phase 3,Phase 1,Phase 2
30 Antiviral Agents Phase 3,Phase 1,Phase 2
31 Antimitotic Agents Phase 2, Phase 3,Phase 3,Phase 1
32 Antineoplastic Agents, Alkylating Phase 3,Phase 1,Phase 2
33 Antineoplastic Agents, Phytogenic Phase 2, Phase 3,Phase 3,Phase 1
34
Hydroxyitraconazole Phase 3
35
protease inhibitors Phase 3
36 Steroid Synthesis Inhibitors Phase 3
37 Cytochrome P-450 CYP2C9 Inhibitors Phase 3
38 Cytochrome P-450 CYP3A Inhibitors Phase 3
39 HIV Protease Inhibitors Phase 3
40 Cytochrome P-450 Enzyme Inhibitors Phase 3
41 Hormone Antagonists Phase 3,Phase 1,Phase 2
42 Hormones Phase 3,Phase 1,Phase 2
43 Angiotensin-Converting Enzyme Inhibitors Phase 3
44 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 1,Phase 2
45 Echinocandins Phase 3
46 Antibodies Phase 3,Phase 1
47 Immunoglobulins Phase 3,Phase 1
48 Antibodies, Monoclonal Phase 3,Phase 1
49 Antihypertensive Agents Phase 3
50 Antifungal Agents Phase 3

Interventional clinical trials:

(show all 35)
# Name Status NCT ID Phase Drugs
1 Combination Chemotherapy in Treating Men With Germ Cell Cancer Unknown status NCT00003643 Phase 2, Phase 3 cisplatin;etoposide;paclitaxel
2 Combination Chemotherapy in Treating Patients With Stage II or Stage III Germ Cell Tumors Unknown status NCT00104676 Phase 3 cisplatin;etoposide;ifosfamide;oxaliplatin;paclitaxel
3 Combination Chemotherapy With or Without Peripheral Stem Cell Transplant in Treating Men With Previously Untreated Germ Cell Cancer Completed NCT00003941 Phase 3 cisplatin;etoposide;ifosfamide
4 Combination Chemotherapy With or Without Bone Marrow or Stem Cell Transplantation in Treating Men With Untreated Germ Cell Tumors Completed NCT00002596 Phase 3 carboplatin;cisplatin;cyclophosphamide;etoposide
5 Captopril in Treating Patients Undergoing Bone Marrow or Stem Cell Transplantation Completed NCT00004230 Phase 3 captopril;cyclophosphamide
6 Ribavirin With or Without Monoclonal Antibody Therapy in Treating Patients Who Develop RSV Pneumonia Following Peripheral Stem Cell Transplantation Completed NCT00014391 Phase 3 ribavirin
7 Itraconazole Compared With Fluconazole to Prevent Infections in Patients Undergoing Peripheral Stem Cell or Bone Marrow Transplantation Completed NCT00003883 Phase 3 fluconazole;itraconazole
8 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
9 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3 liposomal amphotericin B
10 Surgery and Combination Chemotherapy in Treating Children With Extracranial Germ Cell Tumors Completed NCT00053352 Phase 3 cisplatin;etoposide
11 Active Surveillance, Bleomycin, Carboplatin, Etoposide, or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors Recruiting NCT03067181 Phase 3 Bleomycin;Carboplatin;Cisplatin;Etoposide
12 Cisplatin and Ifosfamide Combined With Either Paclitaxel or Vinblastine in Treating Men With Progressive or Recurrent Metastatic Germ Cell Tumors Terminated NCT00072215 Phase 3 cisplatin;ifosfamide;paclitaxel;vinblastine
13 Gemcitabine, Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Progressive or Relapsed Metastatic Germ Cell Tumors Unknown status NCT00551122 Phase 1, Phase 2 cisplatin;gemcitabine hydrochloride;ifosfamide;paclitaxel
14 Combination Chemotherapy in Treating Young Patients With Recurrent or Resistant Malignant Germ Cell Tumors Completed NCT00467051 Phase 2 paclitaxel;carboplatin;ifosfamide
15 Combination Chemotherapy and Pegfilgrastim in Treating Men With Metastatic Germ Cell Tumors Completed NCT00453232 Phase 2 cisplatin;etoposide
16 Combination Chemotherapy and Pegfilgrastim in Treating Patients With Previously Untreated Germ Cell Tumors Completed NCT00470366 Phase 2 cisplatin;ifosfamide;paclitaxel
17 Combination Chemotherapy in Treating Male Patients With Germ Cell Tumors Completed NCT00301782 Phase 2 carboplatin;cisplatin;etoposide phosphate;vincristine sulfate
18 Sunitinib in Treating Patients With Metastatic Germ Cell Tumors That Have Relapsed or Not Responded to Treatment Completed NCT00453310 Phase 2 sunitinib malate
19 Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Relapsed Germ Cell Cancer Completed NCT00002931 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel
20 Immunotherapy in Treating Patients Who Are Undergoing Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00002673 Phase 2
21 Lymphocyte Infusion in Treating Patients With Relapsed Cancer After Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00003887 Phase 2
22 Beclomethasone in Treating Patients With Graft-Versus-Host Disease of the Esophagus, Stomach, Small Intestine, or Colon Completed NCT00010283 Phase 1, Phase 2 beclomethasone dipropionate
23 Interleukin-11 Plus Filgrastim Prior to Peripheral Stem Cell Transplantation in Patients With Non-Hodgkin's Lymphoma, Hodgkin's Disease, Breast Cancer, or Other Solid Tumors Completed NCT00004157 Phase 2
24 Ixabepilone in Treating Patients With Advanced Cisplatin-Refractory Germ Cell Tumors Completed NCT00070096 Phase 2 ixabepilone
25 Biological Therapy Following Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Cancer Completed NCT00003408 Phase 2
26 Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Metastatic Testicular Cancer Completed NCT00004077 Phase 2 cisplatin;ifosfamide;paclitaxel
27 Autologous Peripheral Blood Stem Cell Transplant for Germ Cell Tumors Recruiting NCT00432094 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel;thiotepa;Mesna
28 Role of Axumin PET Scan in Germ Cell Tumor Recruiting NCT03426865 Phase 2 Axumin PET scan
29 Ipilimumab After Allogeneic Stem Cell Transplant in Treating Patients With Persistent or Progressive Cancer Completed NCT00060372 Phase 1 ipilimumab;therapeutic allogeneic lymphocytes
30 Interleukin-12 in Treating Patients With Hematologic Cancers or Solid Tumors Completed NCT00003107 Phase 1
31 Positron Emission Tomography in Detecting Testicle Cancer Completed NCT00045045 Not Applicable
32 Acupuncture in Treating Mucositis-Related Pain Caused by Chemotherapy in Patients Undergoing Stem Cell Transplantation Completed NCT00060021 Not Applicable
33 Standard Follow-up Compared With Extended Follow-up in Treating Patients Who Have Undergone Stem Cell Transplantation for Cancer Completed NCT00049465 Not Applicable
34 Diagnostic Study of Patients With Stage I Testicular Cancer Completed NCT00003800 Not Applicable
35 DNA Analysis in Samples From Younger Patients With Germ Cell Tumors and Their Parents or Siblings Recruiting NCT01434355

Search NIH Clinical Center for Choriocarcinoma of the Testis

Genetic Tests for Choriocarcinoma of the Testis

Anatomical Context for Choriocarcinoma of the Testis

MalaCards organs/tissues related to Choriocarcinoma of the Testis:

41
Testis, Bone, Bone Marrow, Liver, Breast, Colon, Small Intestine

Publications for Choriocarcinoma of the Testis

Articles related to Choriocarcinoma of the Testis:

(show all 12)
# Title Authors Year
1
Choriocarcinoma of the testis. ( 24949806 )
2014
2
Pure choriocarcinoma of the testis presenting with jaundice: a case report and review of the literature. ( 22938171 )
2012
3
Image interpretation session: 1997. Metastatic choriocarcinoma of the testis. ( 9460124 )
1998
4
Severe thrombosis after chemotherapy for metastatic choriocarcinoma of the testis maintaining complete remission for a long period. ( 9165594 )
1997
5
The aggressive treatment of choriocarcinoma of the testis associated with lung bone, and brain metastases. ( 7627844 )
1994
6
Choriocarcinoma of the testis metastatic to the skin. ( 2030209 )
1991
7
Metastatic pure choriocarcinoma of the testis in an elderly man. ( 3820391 )
1987
8
Stage C pure choriocarcinoma of the testis: a potentially curable lesion. ( 6800592 )
1982
9
Choriocarcinoma of the testis. ( 4134907 )
1974
10
Choriocarcinoma of the testis: case report with review of the literature. ( 4533449 )
1973
11
Choriocarcinoma of the testis. ( 4174513 )
1968
12
Choriocarcinoma of the testis and extragenital choriocarcinoma in men. ( 13825140 )
1959

Variations for Choriocarcinoma of the Testis

Expression for Choriocarcinoma of the Testis

Search GEO for disease gene expression data for Choriocarcinoma of the Testis.

Pathways for Choriocarcinoma of the Testis

GO Terms for Choriocarcinoma of the Testis

Sources for Choriocarcinoma of the Testis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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