MCID: CHR078
MIFTS: 50

Chorioretinitis

Categories: Eye diseases, Neuronal diseases, Rare diseases
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Aliases & Classifications for Chorioretinitis

MalaCards integrated aliases for Chorioretinitis:

Name: Chorioretinitis 11 19 75 53 43 14 71
Retinochoroiditis 11

Classifications:



External Ids:

Disease Ontology 11 DOID:8886
ICD9CM 34 363.20
MeSH 43 D002825
NCIt 49 C110923
SNOMED-CT 68 270531006
ICD10 31 H30.9
UMLS 71 C0008513

Summaries for Chorioretinitis

GARD: 19 An inflammation of the choroid and retina.

MalaCards based summary: Chorioretinitis, also known as retinochoroiditis, is related to focal chorioretinitis and birdshot chorioretinopathy, and has symptoms including eye manifestations An important gene associated with Chorioretinitis is RBP3 (Retinol Binding Protein 3), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Prednisolone phosphate and Prednisolone acetate have been mentioned in the context of this disorder. Affiliated tissues include retina, eye and bone marrow, and related phenotypes are no effect and no effect

Wikipedia: 75 Chorioretinitis is an inflammation of the choroid (thin pigmented vascular coat of the eye) and retina... more...

Related Diseases for Chorioretinitis

Diseases related to Chorioretinitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1131)
# Related Disease Score Top Affiliating Genes
1 focal chorioretinitis 32.4 SAG CD4
2 birdshot chorioretinopathy 31.4 TNF SAG RCVRN RBP3 IL17A CD8A
3 pars planitis 30.7 SAG RBP3 IL2 CCR6 ACE
4 retinal detachment 30.6 VEGFA TNF IL6 IL10 IFNG
5 histoplasmosis 30.5 TNF IFNG CD4 CCR6
6 syphilis 30.5 TNF IL17A CRP CD8A CD4 CCR6
7 ocular tuberculosis 30.5 RBP3 IFNG CD4 ACE
8 choroiditis 30.4 VEGFA TNF SAG RBP3 IL17A IL10
9 encephalitis 30.4 TNF IL6 IL1B IL10 CX3CL1
10 chorioretinal scar 30.3 VEGFA CRB1 ACE
11 coccidioidomycosis 30.3 IL17A CD4 CCR6
12 secondary syphilis 30.3 TNF CRP CD8A CD4 ACE
13 optic papillitis 30.3 TNF RBP3 CRP CD4 ACE
14 subacute sclerosing panencephalitis 30.3 TNF IL6 IL2 IL10 IFNG
15 cytomegalovirus retinitis 30.3 TNF IL10 IFNG CD8A CD4
16 hydrocephalus 30.2 VEGFA TNF IL10 IFNG ACE
17 retinal vasculitis 30.2 VEGFA TNF SAG RBP3 CD4 CCR6
18 eales disease 30.2 SAG RBP3
19 primary syphilis 30.1 CD8A CD4
20 nocardiosis 30.1 TNF CRP CD4
21 cat-scratch disease 30.1 CRP CD4 ACE
22 macular retinal edema 30.1 VEGFA TNF IL6 IL1B CRB1 ACE
23 vitreoretinopathy 30.0 VEGFA TNF IL6
24 graft-versus-host disease 30.0 TNF IL2 IL10 IFNG
25 retinal vascular disease 30.0 VEGFA TNF IL6 IL1B ACE
26 optic neuritis 30.0 VEGFA TNF IL6 IL1B IL10
27 congenital toxoplasmosis 30.0 TNF IL1B IL10 IFNG DHFR CD8A
28 endophthalmitis 30.0 VEGFA TNF SAG RBP3 IL6 IL1B
29 scleritis 29.9 TNF IFNG CRP CCR6
30 retinal artery occlusion 29.9 VEGFA IL6 IL10 CRP ACE
31 retinal disease 29.9 VEGFA IL6 CRB1 CCR6
32 thrombocytopenia due to platelet alloimmunization 29.9 IL10 CD8A CD4 CCR6
33 latent syphilis 29.9 IFNG CD4
34 papilledema 29.9 VEGFA IL6 CRP CD4 ACE
35 whipple disease 29.9 TNF CRP CD4
36 vasculitis 29.8 TNF IL6 IL1B IL17A IL10 CX3CL1
37 toxic megacolon 29.8 TNF CRP CCR6
38 posterior uveitis 29.8 VEGFA TNF SAG RBP3 IL6 IL2
39 clostridium difficile colitis 29.8 IL1B CRP CCR6
40 human immunodeficiency virus type 1 29.8 IL2 IL10 IFNG CD4
41 toxocariasis 29.8 IL6 IL10 CRP ACE
42 acute retinal necrosis syndrome 29.8 VEGFA IL6 IL10 IFNG CD8A CD4
43 human cytomegalovirus infection 29.8 TNF IL6 IL17A IL10 CD8A CD4
44 melanoma, uveal 29.8 VEGFA IL2 CD8A CD4
45 myositis 29.8 TNF IL6 IL1B IL17A IFNG
46 langerhans cell histiocytosis 29.8 TNF IL17A CCR6
47 histiocytosis 29.8 TNF IL17A IFNG CCR6
48 lyme disease 29.8 TNF IL6 IL1B IL17A CRP
49 choroid disease 29.8 VEGFA RBP3 CRB1
50 neuritis 29.7 VEGFA TNF IL6 IL1B IL10 IFNG

Graphical network of the top 20 diseases related to Chorioretinitis:



Diseases related to Chorioretinitis

Symptoms & Phenotypes for Chorioretinitis

UMLS symptoms related to Chorioretinitis:


eye manifestations

GenomeRNAi Phenotypes related to Chorioretinitis according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.17 ACE CCR6 CD4 CD8A CRB1 CRP
2 no effect GR00402-S-2 10.17 ACE CCR6 CD4 CRB1 CRP CX3CL1
3 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 10.03 IL10 IL17A IL1B TNF
4 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 10.03 ACE IL10 IL17A IL1B IL2 NOD2
5 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-3 10.03 DHFR

MGI Mouse Phenotypes related to Chorioretinitis:

45 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.41 ACE CCR6 CD4 CRB1 CRP CX3CL1
2 nervous system MP:0003631 10.36 CCR6 CD4 CD8A CRB1 CX3CL1 DHFR
3 immune system MP:0005387 10.25 ACE CCR6 CD4 CD8A CRB1 CRP
4 endocrine/exocrine gland MP:0005379 10.23 ACE CD4 CD8A CRB1 IFNG IL10
5 cellular MP:0005384 10.22 ACE CD4 CD8A CRB1 CX3CL1 DHFR
6 cardiovascular system MP:0005385 10.18 ACE CCR6 CRB1 CRP CX3CL1 DHFR
7 liver/biliary system MP:0005370 10.15 ACE DHFR IFNG IL10 IL17A IL2
8 neoplasm MP:0002006 10.13 ACE IFNG IL10 IL1B IL2 IL6
9 digestive/alimentary MP:0005381 10.09 CD4 IFNG IL10 IL17A IL2 IL6
10 hematopoietic system MP:0005397 10.06 ACE CCR6 CD4 CD8A CRB1 CX3CL1
11 vision/eye MP:0005391 9.96 CRB1 IFNG IL10 IL2 IL6 RBP3
12 mortality/aging MP:0010768 9.8 ACE CD4 CD8A CRB1 DHFR IFNG
13 integument MP:0010771 9.32 CD4 CD8A DHFR IFNG IL10 IL17A

Drugs & Therapeutics for Chorioretinitis

Drugs for Chorioretinitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 48)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
2
Prednisolone acetate Approved, Vet_approved Phase 3 52-21-1
3
Prednisolone Approved, Vet_approved Phase 3 50-24-8 4894 5755
4
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3 3680
5
Sulfadiazine Approved, Investigational, Vet_approved Phase 3 68-35-9 5215
6
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 3003 5743
7
Clindamycin Approved, Vet_approved Phase 3 18323-44-9, 24729-96-2 29029
8
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5 1875
9
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 4159 6741
10
Pyrimethamine Approved, Investigational, Vet_approved Phase 3 58-14-0, 19085-09-7 4993
11
Levoleucovorin Approved, Experimental, Investigational Phase 3 68538-85-2, 58-05-9, 73951-54-9 149436 6006
12
Sulfamethoxazole Approved Phase 3 723-46-6 5329
13
Trimethoprim Approved, Vet_approved Phase 3 738-70-5 5578
14
Folic acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
15
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7 4897
16 Hormones Phase 3
17 Hormone Antagonists Phase 3
18 Gastrointestinal Agents Phase 3
19 glucocorticoids Phase 3
20 Antineoplastic Agents, Hormonal Phase 3
21
Clindamycin phosphate Phase 3 32603
22 Clindamycin palmitate Phase 3
23 Antiemetics Phase 3
24
Methylprednisolone Acetate Phase 3 584547
25 Anti-Infective Agents Phase 3
26 Cytochrome P-450 Enzyme Inhibitors Phase 3
27 Folic Acid Antagonists Phase 3
28 Folate Phase 3
29 Antimalarials Phase 3
30 Vitamin B9 Phase 3
31 Antiprotozoal Agents Phase 3
32 Antiparasitic Agents Phase 3
33 Vitamin B Complex Phase 3
34 Anti-Bacterial Agents Phase 3
35 Trimethoprim, Sulfamethoxazole Drug Combination Phase 3
36
Spironolactone Approved Phase 1, Phase 2 1952-01-7, 52-01-7 5833
37 Mineralocorticoids Phase 1, Phase 2
38 Mineralocorticoid Receptor Antagonists Phase 1, Phase 2
39 Diuretics, Potassium Sparing Phase 1, Phase 2
40 diuretics Phase 1, Phase 2
41
Ranibizumab Approved 347396-82-1
42
Aflibercept Approved 862111-32-8 124490314
43
Fluconazole Approved, Investigational 86386-73-4 3365
44
Miconazole Approved, Investigational, Vet_approved 22916-47-8 4189
45
Clotrimazole Approved, Vet_approved 23593-75-1 2812
46 Anti-Inflammatory Agents
47 Angiogenesis Inhibitors
48 Antifungal Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 To Compare Intravitreal Clindamycin & Dexamethasone With Classic Treatment of Toxoplasmic Retinochoroiditis Unknown status NCT00372294 Phase 3 pyrimethamine-sulfadiazine + prednisolone;Clindamycin+Dexamethasone
2 Influence of Trimethoprim-sulfamethoxazole for the Recurrence of Retinochoroiditis Toxoplasma Gondii Completed NCT01449877 Phase 3 Trimethoprim-Sulfamethoxazole
3 Evaluation de la Spironolactone Dans le Traitement Des choriorétinites séreuses Centrales Non résolutives à Trois Mois Completed NCT01552044 Phase 1, Phase 2 Spironolactone;Placebo
4 Prevalence of Ocular Manifestations in Inflammatory Rheumatic Diseases Completed NCT03753893
5 Evaluation of Biological Biomarkers Diagnostic of Toxoplasmosis Uveitis Completed NCT02843438 Anti-toxoplasmosis treatment;Anti-inflammatory treatments
6 Collaborative Ocular Antiangiogenic Study of Ukraine. Multicentral, Open-label, Randomized, Prospective Study of Antiangiogenic Therapy of Choroidal Neovascularisation Associated With Central Chorioretinitis Recruiting NCT04245072
7 Outcome of SD-OCT Guided Oral Anti-fungal Treatment of Fungal Chorioretinitis Recruiting NCT04947592 Fluconazole 150 mg
8 Chorioretinal Changes in Vitiligo Patients on Therapy Recruiting NCT05335746
9 Longitudinal Cohort Study of Patients With Birdshot Chorioretinopathy. Recruiting NCT05153057
10 Postnatal HCMV Infection in Very Preterm Infants. Implications on Acute and Chronic Morbidity, Growth and Neurodevelopmental Outcomes Part of the Study on "Nutrition, Growth and Development Among Very Preterm Infants". Withdrawn NCT01151462

Search NIH Clinical Center for Chorioretinitis

Cochrane evidence based reviews: chorioretinitis

Genetic Tests for Chorioretinitis

Anatomical Context for Chorioretinitis

Organs/tissues related to Chorioretinitis:

MalaCards : Retina, Eye, Bone Marrow, Spinal Cord, Liver, Bone, Lung

Publications for Chorioretinitis

Articles related to Chorioretinitis:

(show top 50) (show all 2322)
# Title Authors PMID Year
1
Constitutive and inflammatory mediator-regulated fractalkine expression in human ocular tissues and cultured cells. 53 62
12657599 2003
2
The importance of specific IgG and IgE autoantibodies to retinal S antigen, total serum IgE, and sCD23 levels in autoimmune and infectious uveitis. 53 62
10471975 1999
3
Humoral and cell-mediated immune response against human retinal antigens in relation to ocular onchocerciasis. 53 62
2378211 1990
4
Acute syphilitic posterior placoid chorioretinitis as the presenting symptom of syphilis in an immunocompetent patient. 62
36217438 2022
5
Ciclosporin A in bilateral auto-immune chronic posterior uveitis associated with macular oedema: a Long-term Observational Safety and Efficacy Study. 62
34718340 2022
6
Telemedicine screening for syphilitic chorioretinitis in the SUNDROP cohort. 62
35217825 2022
7
Subretinal Exudation and Fibrosis in Relentless Placoid Chorioretinitis. 62
36027999 2022
8
Case Report: Choriocapillaris Flow Voids in Acute Syphilitic Posterior Placoid Chorioretinitis. 62
36067403 2022
9
Prevalence of Toxoplasmic Retinochoroiditis in an Australian Adult Population: A Community-Based Study. 62
35568370 2022
10
Maternal high-dose valacyclovir and its correlation with newborn blood viral load and outcome in congenital cytomegalovirus infection. 62
33143511 2022
11
A de novo YY1 missense variant expanding the Gabriele-de Vries syndrome phenotype and affecting X-chromosome inactivation. 62
35829845 2022
12
TOXOPLASMOSIS RETINOCHOROIDITIS MASQUERADING AS ENDOGENOUS ENDOPHTHALMITIS IN A CASE OF CONGENITAL LONG QT SYNDROME. 62
32910025 2022
13
Pediatric Uveitis in Turkey: The National Registry Report II. 62
36083691 2022
14
Observing the initial onset of retinal vasculitis as unilateral Birdshot Retinochoroiditis becomes bilateral: A case report. 62
35664450 2022
15
Evaluating patient-reported outcome measures (PROMs) for clinical trials and clinical practice in adult patients with uveitis or scleritis: a systematic review. 62
36063293 2022
16
Lymphocytic choriomeningitis virus: An under-recognized congenital teratogen. 62
36157656 2022
17
Association of Proton Pump Inhibitor/Histamine-2 Blocker Use and Ocular Toxoplasmosis: Findings from a Large US National Database. 62
36058521 2022
18
Indocyanine Green Angiography Features in Acute Syphilitic Posterior Placoid Chorioretinitis. 62
35192791 2022
19
Response to: 'Comment on: 'Incidence of chorioretinitis and endophthalmitis in hospitalized patients with fungemia". 62
35046552 2022
20
Comment on: 'Incidence of chorioretinitis and endophthalmitis in hospitalized patients with fungemia'. 62
35082389 2022
21
UNILATERAL ACUTE IDIOPATHIC MACULOPATHY IN A PATIENT WITH HAND-FOOT-MOUTH DISEASE: A CASE REPORT. 62
32910026 2022
22
Clinical and imaging characteristics of outer retinal folds in eyes with retinitis. 62
35918957 2022
23
Swept-source Optical Coherence Tomography Angiography in Active and Scarred Toxoplasmic Retinochoroiditis. 62
35914295 2022
24
Double Trouble in a Patient with Toxoplasma Chorioretinitis. 62
35965136 2022
25
Secondary Syphilis Presenting as Bilateral Simultaneous Papillitis in an Immunocompetent Individual. 62
36176871 2022
26
MULTICOLOR CONFOCAL SCANNING LASER OPHTHALMOSCOPE IMAGING IN POSTERIOR UVEITIS. 62
35723923 2022
27
Bilateral Ocular Tuberculosis in a Child with Negative Tuberculin Skin Test (TST): A Diagnostic Dilemma. 62
33826463 2022
28
Congenital lymphocytic choriomeningitis virus: A review. 62
35695127 2022
29
Treatment Outcomes in Birdshot Chorioretinitis: Corticosteroid Sparing, Corticosteroid Discontinuation, Remission, and Relapse. 62
35283323 2022
30
Infectious Uveitis after Local Steroid and/or Methotrexate Injections at A Tertiary Referral Center in New Zealand: A Case Series. 62
33792480 2022
31
Association of Dupilumab with Intraocular Inflammation. 62
33826474 2022
32
Mycobacterium chimaera chorioretinitis preceding central nervous system lesions: a case report and review of the literature. 62
35869478 2022
33
Multisystem Inflammatory Syndrome in Adults and Severe Toxoplasmosis: Similar Clinical Presentations, Potentially Severe Outcomes. 62
35794941 2022
34
[Ocular toxoplasmosis in infants 0 to 12 months of age with congenital toxoplasmosis]. 62
36156688 2022
35
Kyrieleis arteritis associated with toxoplasmic retinochoroiditis: A case report. 62
35734750 2022
36
Distinguishing swept-source optical coherence tomography findings in active toxoplasmic retinochoroiditis. 62
34117384 2022
37
The multifaceted presentation of syphilitic chorioretinitis examined by multimodal imaging: A case series. 62
35243169 2022
38
Acute Syphilitic Posterior Placoid Chorioretinitis With Subfoveal Choroidal Neovascularization Managed With Anti-VEGF Therapy. 62
35967270 2022
39
Toxoplasma gondii DNA methyltransferases regulate parasitic energy metabolism. 62
35122712 2022
40
Vitreoretinal interface anomalies in patients with a history of toxoplasmosis retinochoroiditis. 62
35344110 2022
41
Ocular Co-infection with Mycobacterium Tuberculosis and Toxoplasma Gondii in an Immunocompetent Patient - A Case Report. 62
33544637 2022
42
Congenital Cytomegalovirus Infection and Ophthalmological Disorders: A Systematic Review. 62
35611826 2022
43
Prevalence of ocular lesions in cats newly diagnosed with histoplasmosis: 55 cases (2015-2022). 62
35594204 2022
44
Saprochaete clavata Chorioretinitis in a Post-chemotherapy Immunocompromised 9-Year-Old Child. 62
35587644 2022
45
Expanded Spectrum of Optical Coherence Tomography Findings in Patients with Ocular Toxoplasmosis. 62
34236280 2022
46
Anterior and posterior uveitis associated with juvenile idiopathic arthritis -case report. 62
35935079 2022
47
[Bartonella henselae myositis: case report in an adolescent]. 62
35338824 2022
48
Treatment of a full-thickness macular hole and retinal detachment secondary to toxoplasma chorioretinitis that developed shortly after COVID-19: A case report. 62
35034856 2022
49
BILATERAL SERPIGINOUS-LIKE CHORIORETINITIS ASSOCIATED WITH CILIOCHOROIDAL MELANOMA: A Clinicopathologic Correlation. 62
35174798 2022
50
Wide-field Fundus Imaging and Fluorescein Angiography Findings in Various Pseudoretinoblastoma Conditions. 62
35446191 2022

Variations for Chorioretinitis

Expression for Chorioretinitis

Search GEO for disease gene expression data for Chorioretinitis.

Pathways for Chorioretinitis

Pathways related to Chorioretinitis according to GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.02 VEGFA TNF NOD2 IL6 IL2 IL1B
2
Show member pathways
13.88 CCR6 CD4 CX3CL1 IL10 IL17A IL1B
3
Show member pathways
13.66 CCR6 CD4 CX3CL1 IFNG IL10 IL17A
4
Show member pathways
13.59 VEGFA TNF IL6 IL2 IL1B IL17A
5
Show member pathways
13.48 TNF IL6 IL2 IL1B IL17A IL10
6
Show member pathways
13.35 CCR6 CD4 CX3CL1 IL10 IL17A IL1B
7
Show member pathways
13.35 VEGFA TNF NOD2 IL6 IL2 IL1B
8
Show member pathways
12.72 TNF IL6 IL2 IL1B IL17A IL10
9
Show member pathways
12.67 TNF IL6 IL2 IL1B IL17A IL10
10 12.62 CD8A IFNG IL10 IL17A IL1B IL2
11
Show member pathways
12.52 TNF NOD2 IL6 IL1B
12
Show member pathways
12.43 TNF IL6 IL1B IFNG
13
Show member pathways
12.33 TNF IL6 IL1B IFNG
14 12.27 VEGFA TNF IL6 IL1B IL10
15 12.23 VEGFA TNF IL6 IFNG
16
Show member pathways
12.2 TNF IL2 IL17A IL10 IFNG CD8A
17 12.19 TNF IL6 IL1B IL10 IFNG
18 12.07 TNF IL6 IL2 IL1B IFNG
19 12.06 VEGFA TNF IL6 IL1B IL17A IL10
20
Show member pathways
12.05 IL2 IL1B IFNG CD8A CD4
21 11.98 SAG RCVRN RBP3 CRP
22 11.98 VEGFA IL6 IL10 CCR6
23 11.98 CD4 CD8A IFNG IL10 IL2 IL6
24
Show member pathways
11.94 CD4 IFNG IL17A IL1B IL6
25
Show member pathways
11.88 CD4 CD8A CRP IL6
26 11.86 VEGFA TNF IL6 IL1B
27
Show member pathways
11.86 TNF IL6 IL2 IL1B IL17A IL10
28 11.84 IL6 IL2 IL10 IFNG CD4
29 11.83 VEGFA TNF IL2 IL1B IL17A IL10
30 11.82 IL6 IL2 IL10 IFNG
31 11.82 TNF IL6 IL2 IL10 IFNG CRP
32
Show member pathways
11.81 TNF IL1B IFNG
33 11.79 IL6 IL2 IFNG
34 11.77 IL10 IL1B IL6 TNF
35 11.77 CD4 IFNG IL17A IL1B IL2 IL6
36
Show member pathways
11.72 IFNG IL2 TNF
37
Show member pathways
11.71 VEGFA TNF IL6 IL2 IL1B IFNG
38 11.7 TNF IL6 IL1B
39 11.69 TNF IL6 IL10
40 11.69 VEGFA IL6 IL2 IFNG
41 11.66 IFNG IL6 NOD2 TNF
42
Show member pathways
11.65 TNF NOD2 IL6 IL2 IL10 IFNG
43 11.63 CD4 CD8A IFNG IL10 IL1B IL2
44 11.62 TNF IL6 IL1B IL10
45 11.62 TNF IL2 IL10 IFNG CD4
46 11.6 IL2 IL10 IFNG CD4
47 11.58 TNF IL6 IL1B IFNG
48 11.57 TNF IL1B IFNG
49
Show member pathways
11.46 TNF IL2 IL10 IFNG
50 11.44 TNF IL6 IL1B IL10

GO Terms for Chorioretinitis

Cellular components related to Chorioretinitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 10.03 ACE CRP CX3CL1 IFNG IL10 IL17A
2 external side of plasma membrane GO:0009897 9.93 TNF IL17A CD8A CD4 CCR6 ACE
3 extracellular region GO:0005576 9.77 VEGFA TNF RBP3 IL6 IL2 IL1B

Biological processes related to Chorioretinitis according to GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.65 CX3CL1 IL10 IL17A IL1B IL2 IL6
2 signal transduction GO:0007165 10.6 VEGFA TNF SAG RCVRN IL6 IL1B
3 inflammatory response GO:0006954 10.48 TNF IL6 IL1B IL17A CX3CL1 CRP
4 positive regulation of cell population proliferation GO:0008284 10.45 CX3CL1 IFNG IL1B IL2 IL6 NOD2
5 cell-cell signaling GO:0007267 10.4 CRB1 CX3CL1 IL17A IL1B IL2
6 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 10.36 TNF NOD2 IL1B CX3CL1 CD4
7 positive regulation of ERK1 and ERK2 cascade GO:0070374 10.35 VEGFA TNF NOD2 CX3CL1 CD4
8 positive regulation of protein phosphorylation GO:0001934 10.34 CD4 IL1B IL2 TNF VEGFA
9 positive regulation of DNA-binding transcription factor activity GO:0051091 10.32 TNF IL6 IL1B IL10
10 positive regulation of tumor necrosis factor production GO:0032760 10.3 NOD2 IL6 IL17A IFNG
11 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 10.28 VEGFA NOD2 IL6 CD4
12 cellular response to lipopolysaccharide GO:0071222 10.28 TNF NOD2 IL6 IL1B IL10
13 positive regulation of NF-kappaB transcription factor activity GO:0051092 10.26 TNF NOD2 IL6 IL1B CX3CL1
14 positive regulation of MAP kinase activity GO:0043406 10.24 VEGFA TNF NOD2 IL1B
15 positive regulation of interleukin-8 production GO:0032757 10.21 TNF NOD2 IL6 IL1B
16 positive regulation of nitric oxide biosynthetic process GO:0045429 10.2 TNF IL1B IFNG
17 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 10.19 TNF IL1B CX3CL1
18 positive regulation of receptor signaling pathway via JAK-STAT GO:0046427 10.19 TNF IL6 IL10
19 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 10.19 CX3CL1 IL1B IL2
20 humoral immune response GO:0006959 10.19 TNF IL6 IFNG CCR6
21 liver regeneration GO:0097421 10.17 TNF IL6 IL10
22 positive regulation of cytokine production GO:0001819 10.17 TNF IL1B IL10 IFNG
23 positive regulation of immunoglobulin production GO:0002639 10.16 IL6 IL2 IL10
24 positive regulation of MAPK cascade GO:0043410 10.16 VEGFA TNF NOD2 IL6 CX3CL1 CD4
25 microglial cell activation GO:0001774 10.15 CX3CL1 IFNG TNF
26 negative regulation of neurogenesis GO:0050768 10.15 TNF IL6 IL1B
27 positive regulation of phagocytosis GO:0050766 10.15 TNF NOD2 IL1B IFNG
28 positive regulation of interleukin-17 production GO:0032740 10.14 NOD2 IL6 IL2
29 macrophage differentiation GO:0030225 10.14 VEGFA IFNG CD4
30 response to lipopolysaccharide GO:0032496 10.14 ACE IL10 IL1B NOD2 TNF
31 regulation of insulin secretion GO:0050796 10.14 TNF IL6 IL1B IFNG
32 positive regulation of osteoclast differentiation GO:0045672 10.13 IFNG IL17A TNF
33 positive regulation of glial cell proliferation GO:0060252 10.09 IL1B IL6 TNF
34 positive regulation of membrane protein ectodomain proteolysis GO:0051044 10.08 TNF IL1B IFNG
35 positive regulation of chemokine production GO:0032722 10.07 TNF IL6 IL1B IFNG
36 positive regulation of interleukin-1 beta production GO:0032731 10.07 TNF NOD2 IL6 IL17A IFNG
37 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 10.06 VEGFA TNF IL6 IL2 IFNG
38 defense response to Gram-positive bacterium GO:0050830 10.06 CRP IL17A IL1B IL6 NOD2 TNF
39 positive regulation of heterotypic cell-cell adhesion GO:0034116 10.05 TNF IL1B IL10
40 astrocyte activation GO:0048143 10.04 TNF IL1B IFNG
41 negative regulation of cytokine production involved in immune response GO:0002719 10.03 TNF IL10
42 leukocyte migration involved in inflammatory response GO:0002523 10.03 CCR6 CX3CL1 TNF
43 positive regulation of cytokine production involved in inflammatory response GO:1900017 10.03 IL17A IL6 NOD2 TNF
44 positive regulation of fever generation GO:0031622 10.02 IL1B TNF
45 negative regulation of interleukin-18 production GO:0032701 10.01 NOD2 IL10
46 sequestering of triglyceride GO:0030730 10.01 TNF IL1B
47 positive regulation of peptidyl-tyrosine autophosphorylation GO:1900086 10 VEGFA ACE
48 positive regulation of plasma cell differentiation GO:1900100 9.99 IL2 IL10
49 positive regulation of neuroinflammatory response GO:0150078 9.99 IL1B IL6 TNF
50 positive regulation of nitrogen compound metabolic process GO:0051173 9.98 TNF IFNG

Molecular functions related to Chorioretinitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.55 VEGFA TNF IL6 IL2 IL1B IL17A

Sources for Chorioretinitis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 24-Oct-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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