MCID: CHR078
MIFTS: 39

Chorioretinitis

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Chorioretinitis

MalaCards integrated aliases for Chorioretinitis:

Name: Chorioretinitis 12 77 54 56 45 15 74
Retinochoroiditis 12

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases


External Ids:

Disease Ontology 12 DOID:8886
ICD9CM 36 363.20
MeSH 45 D002825
NCIt 51 C110923
SNOMED-CT 69 46627006
ICD10 34 H30 H30.9
UMLS 74 C0008513

Summaries for Chorioretinitis

MalaCards based summary : Chorioretinitis, also known as retinochoroiditis, is related to uveitis and panuveitis, and has symptoms including eye manifestations An important gene associated with Chorioretinitis is RBP3 (Retinol Binding Protein 3), and among its related pathways/superpathways is Microglia Activation During Neuroinflammation: Microglia Polarization. The drugs Prednisolone phosphate and Clindamycin have been mentioned in the context of this disorder. Affiliated tissues include retina, eye and lung, and related phenotype is nervous system.

Wikipedia : 77 Chorioretinitis is an inflammation of the choroid (thin pigmented vascular coat of the eye) and retina... more...

Related Diseases for Chorioretinitis

Diseases related to Chorioretinitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 303)
# Related Disease Score Top Affiliating Genes
1 uveitis 30.3 IFNG RBP3 SAG
2 panuveitis 30.1 MRAP RBP3 SAG
3 optic papillitis 29.9 EXTL3 MRAP
4 asymptomatic neurosyphilis 29.8 EXTL3 IFNG
5 posterior uveitis 29.7 IFNG RBP3 SAG
6 eales disease 29.5 IFNG RBP3 SAG
7 autoimmune uveitis 29.5 IFNG RBP3 SAG
8 retinochoroidal coloboma 12.6
9 sveinsson chorioretinal atrophy 12.6
10 pigmented paravenous chorioretinal atrophy 12.5
11 microcornea, myopic chorioretinal atrophy, and telecanthus 12.5
12 chorioretinal atrophy, progressive bifocal 12.5
13 focal chorioretinitis 12.4
14 chorioretinal scar 12.3
15 aicardi syndrome 12.3
16 disseminated chorioretinitis 12.2
17 boucher-neuhauser syndrome 12.1
18 peripheral focal chorioretinitis 12.1
19 cleft lower lip cleft lateral canthi chorioretinal 12.0
20 ataxia - hypogonadism - choroidal dystrophy 12.0
21 birdshot chorioretinopathy 11.9
22 microcephaly with or without chorioretinopathy, lymphedema, or mental retardation 11.8
23 gyrate atrophy of choroid and retina 11.6
24 choroiditis 11.6
25 microcephaly and chorioretinopathy, autosomal recessive, 1 11.5
26 congenital toxoplasmosis 11.5
27 choroideremia 11.4
28 microcornea posterior megalolenticonus persistent fetal vasculature coloboma 11.3
29 wagner vitreoretinopathy 11.3
30 vitreoretinochoroidopathy 11.2
31 oliver-mcfarlane syndrome 11.2
32 late-onset retinal degeneration 11.2
33 arima syndrome 11.2
34 joubert syndrome with oculorenal anomalies 11.2
35 noble bass sherman syndrome 11.2
36 cone-rod dystrophy 2 11.1
37 aicardi-goutieres syndrome 1 11.1
38 microcephaly and chorioretinopathy, autosomal recessive, 3 11.1
39 peripapillary atrophy, beta type 11.0
40 stickler syndrome, type i 11.0
41 optic disc anomalies with retinal and/or macular dystrophy 11.0
42 hypomagnesemia 5, renal, with or without ocular involvement 11.0
43 linear skin defects with multiple congenital anomalies 1 11.0
44 stickler syndrome, type ii 11.0
45 stickler syndrome, type iv 11.0
46 retinal dystrophy with or without extraocular anomalies 11.0
47 microcephaly and chorioretinopathy 3 11.0
48 oguchi disease 11.0
49 trichomegaly with intellectual disability, dwarfism and pigmentary degeneration of retina 11.0
50 retinitis 10.8

Graphical network of the top 20 diseases related to Chorioretinitis:



Diseases related to Chorioretinitis

Symptoms & Phenotypes for Chorioretinitis

UMLS symptoms related to Chorioretinitis:


eye manifestations

MGI Mouse Phenotypes related to Chorioretinitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.1 CX3CL1 IFNG RBP3 SAG SLC44A2 SRCIN1

Drugs & Therapeutics for Chorioretinitis

Drugs for Chorioretinitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 69)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
2
Clindamycin Approved, Vet_approved Phase 3 18323-44-9 29029
3
leucovorin Approved Phase 3 58-05-9 143 6006
4
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
5
Pyrimethamine Approved, Investigational, Vet_approved Phase 3 58-14-0 4993
6
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
7
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
8
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
9
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
10
Sulfadiazine Approved, Investigational, Vet_approved Phase 3 68-35-9 5215
11
Sulfamethoxazole Approved Phase 3 723-46-6 5329
12
Trimethoprim Approved, Vet_approved Phase 3 738-70-5 5578
13
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
14
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7
15 Protective Agents Phase 3
16 glucocorticoids Phase 3,Phase 2
17 Clindamycin phosphate Phase 3
18 Neuroprotective Agents Phase 3
19 Anti-Inflammatory Agents Phase 3,Phase 2,Not Applicable
20 Antineoplastic Agents, Hormonal Phase 3,Phase 2
21 Folate Phase 3
22 Vitamin B Complex Phase 3
23 Folic Acid Antagonists Phase 3
24 Peripheral Nervous System Agents Phase 3
25 Hormones Phase 3,Phase 1,Phase 2
26 Vitamin B9 Phase 3
27 Hormone Antagonists Phase 3,Phase 1,Phase 2
28 Anti-Bacterial Agents Phase 3
29 Anti-Infective Agents Phase 3,Phase 2
30 Antimalarials Phase 3
31 Antiemetics Phase 3
32 Prednisolone acetate Phase 3
33
protease inhibitors Phase 3
34 Antiparasitic Agents Phase 3
35 Methylprednisolone Acetate Phase 3
36 HIV Protease Inhibitors Phase 3
37 Autonomic Agents Phase 3
38 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 1,Phase 2
39 Gastrointestinal Agents Phase 3
40 Antiprotozoal Agents Phase 3
41 BB 1101 Phase 3
42 Clindamycin palmitate Phase 3
43 Anti-Infective Agents, Urinary Phase 3
44 Trimethoprim, Sulfamethoxazole Drug Combination Phase 3
45 Cytochrome P-450 Enzyme Inhibitors Phase 3
46 Renal Agents Phase 3
47 Antibodies Phase 3
48 Immunoglobulins, Intravenous Phase 3
49 Rho(D) Immune Globulin Phase 3
50 gamma-Globulins Phase 3

Interventional clinical trials:

(show all 15)
# Name Status NCT ID Phase Drugs
1 To Compare Intravitreal Clindamycin & Dexamethasone With Classic Treatment of Toxoplasmic Retinochoroiditis Unknown status NCT00372294 Phase 3 pyrimethamine-sulfadiazine + prednisolone;Clindamycin+Dexamethasone
2 Assessment of Two Therapeutic Strategies in the Treatment of Children With Congenital Toxoplasmosis Unknown status NCT01202500 Phase 3
3 Influence of Trimethoprim-Sulfamethoxazole for the Recurrence of Ocular Toxoplasmosis Completed NCT01449877 Phase 3 Trimethoprim-Sulfamethoxazole
4 A Randomized Trial to Prevent Congenital Cytomegalovirus (CMV) Active, not recruiting NCT01376778 Phase 3 CMV hyperimmune globulin
5 Effect of Spironolactone in Treating Chronic Non-resolutive Central Serous Chorioretinitis Completed NCT01552044 Phase 1, Phase 2 Spironolactone;Placebo
6 Evaluation of Birdshot Retine Choroidopathy Treatment by Either Steroid or Interferon alpha2a Completed NCT00508040 Phase 2 interferon alpha 2a;prednisone
7 Safety and Efficacy of AIN457 in Noninfectious Uveitis Completed NCT00685399 Phase 2 AIN457;AIN 457;AIN457
8 ACTH as A Re-emerging theRapy for Uveitis (The ACTHAR Study) Recruiting NCT02931175 Phase 2 ACTH gel
9 Evaluation of Biological Biomarkers Diagnostic of Toxoplasmosis Uveitis Completed NCT02843438 Not Applicable Anti-toxoplasmosis treatment;Anti-inflammatory treatments
10 Study of the Choroidal Thickness Variations After Ingestion of RedBull® Energy Drink Completed NCT02856256 Not Applicable
11 Relevance of Gastric Aspirate in HCMV Detection Recruiting NCT03262194
12 Lyon Cohort of Maternal and Congenital Toxoplasma Infections Recruiting NCT02936921
13 Genetics of Uveitis Recruiting NCT02357238
14 Ocular Manifestations in Rheumatic Diseases Active, not recruiting NCT03753893
15 Postnatal HCMV Infection in Very Preterm Infants. Implications, Morbidity, Growth and Neurodevelopmental Outcomes. Withdrawn NCT01151462

Search NIH Clinical Center for Chorioretinitis

Cochrane evidence based reviews: chorioretinitis

Genetic Tests for Chorioretinitis

Anatomical Context for Chorioretinitis

MalaCards organs/tissues related to Chorioretinitis:

42
Retina, Eye, Lung, Bone, Heart, Liver, B Cells

Publications for Chorioretinitis

Articles related to Chorioretinitis:

(show top 50) (show all 634)
# Title Authors Year
1
A case of cancer-associated retinopathy with chorioretinitis and optic neuritis associated with occult small cell lung cancer. ( 31046716 )
2019
2
"Acute syphilitic posterior placoid chorioretinitis". ( 30690580 )
2019
3
Multimodal Imaging of Atypical Acute Syphilitic Posterior Placoid Chorioretinitis Mimicking a White Dot Syndrome. ( 30768231 )
2019
4
Alendronate induced chorioretinitis: The importance of meticulous assessments. ( 30809598 )
2019
5
Multimodal imaging including adaptive optics: A case of a candida chorioretinitis progressing to endogenous endophthalmitis. ( 30824310 )
2019
6
Traumatic chorioretinitis sclopetaria: Risk factors, management, and prognosis. ( 30834355 )
2019
7
Optical Coherence Tomography Angiography of Retinal-Choroidal Anastomosis in Toxoplasmosis Chorioretinitis. ( 30869760 )
2019
8
The 'pitchfork sign' on optical coherence tomography in a case of acute syphilitic posterior placoid chorioretinitis. ( 30900828 )
2019
9
Cyclosporine and prednisolone combination therapy as a potential therapeutic strategy for relentless placoid chorioretinitis. ( 30984889 )
2019
10
Choriovitreal Neovascularization After Resolution of Infectious Chorioretinitis. ( 31090687 )
2019
11
Curvilinear branching retinal deposits in acute syphilitic posterior placoid chorioretinitis: a novel pattern on en-face optical coherence tomography. ( 31090989 )
2019
12
GOOD VISUAL OUTCOME IN A BILATERAL MULTIFOCAL SYPHILITIC CHORIORETINITIS, DESPITE LATE DIAGNOSIS. ( 28125501 )
2019
13
CLINICAL PATHOLOGIC CORRELATION OF SARCOIDOSIS-ASSOCIATED MULTIFOCAL CHORIORETINITIS IN AN ELDERLY PATIENT. ( 28145942 )
2019
14
RELENTLESS PLACOID CHORIORETINITIS: SUCCESSFUL LONG-TERM TREATMENT WITH INTRAVITREAL TRIAMCINOLONE. ( 28198750 )
2019
15
Choroidal Thickness in Birdshot Retinochoroiditis Over a 2-Year Period. ( 29920484 )
2019
16
Clinical and Biological Factors Associated With Recurrences of Severe Toxoplasmic Retinochoroiditis Confirmed by Aqueous Humor Analysis. ( 30502335 )
2019
17
Toxoplasmic retinochoroiditis: The influence of age, number of retinochoroidal lesions and genetic polymorphism for IFN-γ +874 T/A as risk factors for recurrence in a survival analysis. ( 30753197 )
2019
18
Primary Acquired Toxoplasma Retinochoroiditis: Choroidal Neovascular Membrane as an Early Complication. ( 30989010 )
2019
19
PERIVASCULAR THICKENING ON OPTICAL COHERENCE TOMOGRAPHY AS A MARKER OF INFLAMMATION IN BIRDSHOT RETINOCHOROIDITIS. ( 29543632 )
2019
20
Varicella zoster virus-associated Chorioretinitis: a case report. ( 29402251 )
2018
21
Syphilitic chorioretinitis: Final outcome without treatment. ( 29452719 )
2018
22
Fungaemia caused by obstructive renal candida bezoars leads to bilateral chorioretinitis: a case report. ( 29548319 )
2018
23
NUT carcinoma of the sinonasal tract infiltrating the orbit in a man with birdshot chorioretinitis. ( 29755274 )
2018
24
Chorioretinitis sclopetaria caused by an intraorbital metallic foreign body. ( 29924198 )
2018
25
Unilateral macular chorioretinitis in subacute sclerosing panencephalitis studied by spectral domain optical coherence tomography. ( 29942191 )
2018
26
Pregnancy-induced hypertension-related chorioretinitis resembling uveal effusion syndrome: A case report. ( 30045283 )
2018
27
PRESUMED FOVEAL BACILLARY LAYER DETACHMENT IN A PATIENT WITH TOXOPLASMOSIS CHORIORETINITIS AND PACHYCHOROID DISEASE. ( 30142112 )
2018
28
Multimodal imaging of multifocal chorioretinitis secondary to endogenous candida infection. ( 30293205 )
2018
29
Menagerie: <em>Bartonella henselae</em> chorioretinitis in the setting of diverse animal exposure. ( 30376658 )
2018
30
A challenging case of chorioretinitis and skin lesions in a lung transplant recipient. ( 30476363 )
2018
31
Comparison of Retinal and Choroidal Involvement in Sarcoidosis-related Chorioretinitis Using Fluorescein and Indocyanine Green Angiography. ( 30479712 )
2018
32
Swept-source optical coherence tomography and optical coherence tomography angiography in acquired toxoplasmic chorioretinitis: a case report. ( 30509327 )
2018
33
Congenital central toxoplasmic chorioretinitis - case study. ( 30650975 )
2018
34
Histiocytic chorioretinitis in a dog. ( 27520710 )
2018
35
Stroke Due to Cerebral Vasculitis in a Patient with Relentless Placoid Chorioretinitis. ( 28282738 )
2018
36
Bevacizumab for treatment of choroidal neovascularization secondary to candida chorioretinitis. ( 28361379 )
2018
37
MULTIMODAL IMAGING ADDS NEW INSIGHTS INTO ACUTE SYPHILITIC POSTERIOR PLACOID CHORIORETINITIS. ( 29023263 )
2018
38
Management of giant retinal tear and retinal detachment in a patient with active toxoplasmosis retinochoroiditis. ( 29780938 )
2018
39
Early diagnosis and successful treatment of acquired toxoplasmosis infectious retinochoroiditis: A case report. ( 29952985 )
2018
40
Contribution of dual fluorescein and indocyanine green angiography to the appraisal of posterior involvement in birdshot retinochoroiditis and Vogt-Koyanagi-Harada disease. ( 28299496 )
2018
41
Immune Mediators against Toxoplasma Gondii during Reactivation of Toxoplasmic Retinochoroiditis. ( 30081671 )
2018
42
Adverse Reactions in Antifolate-Treated Toxoplasmic Retinochoroiditis. ( 30191431 )
2018
43
Eccentric fixation patterns, clinical findings, and reading speed in patients with bilateral toxoplasmic macular retinochoroiditis. ( 30208142 )
2018
44
Low-grade "benign" birdshot retinochoroiditis: prevalence and characteristics. ( 30474776 )
2018
45
Tattoo associated retinochoroiditis. ( 28844569 )
2018
46
Safety profile and efficacy of tacrolimus in the treatment of birdshot retinochoroiditis: a retrospective case series review. ( 29051329 )
2018
47
Failure of systemic oral doxycycline in preventing ocular toxoplasmic retinochoroiditis in French military personnel. ( 29317472 )
2018
48
Intravitreal Clindamycin and Dexamethasone Combined with Systemic Oral Antitoxoplasma Therapy versus Intravitreal Therapy Alone in the Management of Toxoplasma Retinochoroiditis: A Retrospective Study. ( 29619254 )
2018
49
Toxoplasmic retinochoroiditis caused by Toxoplasma gondii strain ToxoDB#65. ( 29859747 )
2018
50
Bilateral Birdshot Retinochoroiditis and Retinal Astrocytoma. ( 28321351 )
2017

Variations for Chorioretinitis

Expression for Chorioretinitis

Search GEO for disease gene expression data for Chorioretinitis.

Pathways for Chorioretinitis

Pathways related to Chorioretinitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.47 CX3CL1 IFNG

GO Terms for Chorioretinitis

Cellular components related to Chorioretinitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell projection GO:0042995 8.92 AZIN2 CX3CL1 SAG SRCIN1

Sources for Chorioretinitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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