MCID: CHR078
MIFTS: 50

Chorioretinitis

Categories: Eye diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Chorioretinitis

MalaCards integrated aliases for Chorioretinitis:

Name: Chorioretinitis 12 73 20 54 44 15 70
Retinochoroiditis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8886
ICD9CM 34 363.20
MeSH 44 D002825
NCIt 50 C110923
SNOMED-CT 67 270531006
ICD10 32 H30.9
UMLS 70 C0008513

Summaries for Chorioretinitis

MalaCards based summary : Chorioretinitis, also known as retinochoroiditis, is related to congenital toxoplasmosis and neurosyphilis, and has symptoms including eye manifestations An important gene associated with Chorioretinitis is RBP3 (Retinol Binding Protein 3), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Dexamethasone and Prednisolone acetate have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and bone marrow, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia : 73 Chorioretinitis is an inflammation of the choroid (thin pigmented vascular coat of the eye) and retina... more...

Related Diseases for Chorioretinitis

Diseases related to Chorioretinitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1020)
# Related Disease Score Top Affiliating Genes
1 congenital toxoplasmosis 31.5 IL10 CD8A CD4 ABCA4
2 neurosyphilis 30.8 IL17A IL10
3 multifocal choroiditis 30.7 TNF IL10
4 ocular toxoplasmosis 30.7 NOD2 IL17A
5 neuroretinitis 30.6 SAG CRP CD4 ACE
6 asymptomatic neurosyphilis 30.6 IL17A CD4
7 histoplasmosis 30.6 TNF IFNG CD4
8 ocular tuberculosis 30.5 IFNG CD4 ACE
9 retinal vasculitis 30.4 TNF SAG RBP3 CD4 ACE
10 secondary syphilis 30.4 CRP CD8A CD4
11 retinal detachment 30.4 VEGFA TNF IL6 IL10 IFNG
12 hydrocephalus 30.2 VEGFA TNF IL10 ACE
13 posterior uveitis 30.2 TNF SAG RBP3 IL6 IL2 IFNG
14 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 30.2 IL17A IL10 IFNG
15 subacute sclerosing panencephalitis 30.2 TNF IL6 IL2 IL10 IFNG
16 punctate inner choroidopathy 30.1 TNF IL10
17 cytomegalovirus retinitis 30.1 TNF IL10 IFNG CD8A CD4
18 encephalitis 30.1 TNF IL6 IL1B IL10 CX3CL1
19 latent syphilis 30.1 CD8A CD4
20 vasculitis 30.1 TNF IL6 IL17A CX3CL1 CRP
21 optic papillitis 30.0 SAG RBP3 CRP CD4 ACE
22 toxoplasmosis 30.0 TNF IL6 IL1B IL10 IFNG ABCA4
23 acute retinal necrosis syndrome 30.0 IL6 IL10 CD8A CD4
24 sympathetic ophthalmia 29.9 TNF RBP3 IL10
25 primary syphilis 29.9 CRP CD8A CD4
26 drug reaction with eosinophilia and systemic symptoms 29.9 TNF CRP
27 cryptococcal meningitis 29.9 VEGFA IFNG CD4
28 cat-scratch disease 29.9 CRP CD4 ACE
29 macular holes 29.8 VEGFA RBP3 IL6
30 papilledema 29.8 VEGFA CRP CD4 ACE
31 blastomycosis 29.8 IL6 IL17A CD4
32 scotoma 29.8 VEGFA CRB1 ABCA4
33 dengue disease 29.8 TNF IL10 IFNG CD8A
34 syphilis 29.8 TNF IL6 IL17A IFNG CRP CD8A
35 histiocytosis 29.8 TNF IL17A IFNG
36 thrombocytopenia due to platelet alloimmunization 29.8 IL17A IL10 CD8A CD4
37 vogt-koyanagi-harada disease 29.7 IL17A IL10 IFNG CD8A
38 retinal vascular occlusion 29.7 VEGFA IL6 CRP
39 nocardiosis 29.7 TNF IFNG CRP CD4
40 optic neuritis 29.7 VEGFA TNF IL6 IL1B IL10
41 retinal vascular disease 29.7 VEGFA TNF IL6 IL1B ACE
42 scleritis 29.7 TNF IFNG CRP
43 cervical adenitis 29.7 IL1B CRP CD4
44 endophthalmitis 29.7 VEGFA TNF SAG IL6 IL1B CRP
45 invasive aspergillosis 29.7 NOD2 IL10 IFNG
46 cryptococcosis 29.7 TNF IL17A IL10 IFNG CD8A CD4
47 macular retinal edema 29.6 VEGFA TNF IL6 IL1B CRB1 ACE
48 lymphopenia 29.6 IL6 IL2 IL10 IFNG
49 paracoccidioidomycosis 29.6 TNF IL6 IL2 IL10 IFNG
50 t cell deficiency 29.6 IL2 IL17A CD8A CD4

Graphical network of the top 20 diseases related to Chorioretinitis:



Diseases related to Chorioretinitis

Symptoms & Phenotypes for Chorioretinitis

UMLS symptoms related to Chorioretinitis:


eye manifestations

GenomeRNAi Phenotypes related to Chorioretinitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.36 IL10 IL17A IL1B TNF
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.36 ACE IL10 IL17A IL1B IL2 NOD2

MGI Mouse Phenotypes related to Chorioretinitis:

46 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.34 ABCA4 ACE CD4 CRB1 CRP CX3CL1
2 hematopoietic system MP:0005397 10.33 ABCA4 ACE CD4 CD8A CRB1 CX3CL1
3 cardiovascular system MP:0005385 10.3 ABCA4 ACE CRB1 CRP CX3CL1 IFNG
4 immune system MP:0005387 10.28 ACE CD4 CD8A CRB1 CRP CX3CL1
5 cellular MP:0005384 10.25 CD4 CD8A CRB1 CX3CL1 IFNG IL10
6 endocrine/exocrine gland MP:0005379 10.22 ACE CD4 CD8A CRB1 IFNG IL10
7 digestive/alimentary MP:0005381 10.15 CD4 IFNG IL10 IL17A IL2 IL6
8 mortality/aging MP:0010768 10.13 ACE CD4 CD8A CRB1 IFNG IL10
9 integument MP:0010771 10.02 CD4 CD8A IFNG IL10 IL17A IL1B
10 nervous system MP:0003631 10 ABCA4 ACE CD4 CD8A CRB1 CX3CL1
11 neoplasm MP:0002006 9.86 ACE IFNG IL10 IL1B IL2 IL6
12 no phenotypic analysis MP:0003012 9.5 CD4 IFNG IL10 IL17A IL2 TNF
13 vision/eye MP:0005391 9.4 ABCA4 ACE CRB1 CX3CL1 IFNG IL10

Drugs & Therapeutics for Chorioretinitis

Drugs for Chorioretinitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 52)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
2
Prednisolone acetate Approved, Vet_approved Phase 3 52-21-1
3
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
4
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
5
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
6
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
7
Sulfadiazine Approved, Investigational, Vet_approved Phase 3 68-35-9 5215
8
Pyrimethamine Approved, Investigational, Vet_approved Phase 3 58-14-0 4993
9
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
10
Clindamycin Approved, Vet_approved Phase 3 18323-44-9 29029
11
Levoleucovorin Approved, Investigational Phase 3 68538-85-2 149436
12
Sulfamethoxazole Approved Phase 3 723-46-6 5329
13
Trimethoprim Approved, Vet_approved Phase 3 738-70-5 5578
14
Sodium citrate Approved, Investigational Phase 3 68-04-2
15
Tadalafil Approved, Investigational Phase 3 171596-29-5 110635
16
Folic acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
17
Citric acid Approved, Nutraceutical, Vet_approved Phase 3 77-92-9 311
18
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7
19 Methylprednisolone Acetate Phase 3
20 Gastrointestinal Agents Phase 3
21 Antiemetics Phase 3
22 Clindamycin phosphate Phase 3
23 Clindamycin palmitate Phase 3
24 Antineoplastic Agents, Hormonal Phase 3
25 glucocorticoids Phase 3
26 Vitamin B9 Phase 3
27 Anti-Infective Agents Phase 3
28 Folic Acid Antagonists Phase 3
29 Antimalarials Phase 3
30 Antiparasitic Agents Phase 3
31 Vitamin B Complex Phase 3
32 Antiprotozoal Agents Phase 3
33 Folate Phase 3
34 Anti-Bacterial Agents Phase 3
35 Cytochrome P-450 Enzyme Inhibitors Phase 3
36 Trimethoprim, Sulfamethoxazole Drug Combination Phase 3
37 Vasodilator Agents Phase 3
38 Citrate Phase 3
39 Phosphodiesterase Inhibitors Phase 3
40 Phosphodiesterase 5 Inhibitors Phase 3
41 Sildenafil Citrate Phase 3 171599-83-0
42
Ranibizumab Approved Phase 1, Phase 2 347396-82-1 459903
43
Spironolactone Approved Phase 1, Phase 2 1952-01-7, 52-01-7 5833
44 Hormones Phase 1, Phase 2
45 Hormone Antagonists Phase 1, Phase 2
46 Angiogenesis Inhibitors Phase 1, Phase 2
47 Mineralocorticoids Phase 1, Phase 2
48 Mineralocorticoid Receptor Antagonists Phase 1, Phase 2
49 diuretics Phase 1, Phase 2
50 Diuretics, Potassium Sparing Phase 1, Phase 2

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 A Study in Patients With Chorioretinal Vascular Disease to Evaluate an Aflibercept (EYLEA®) Prefilled Syringe Completed NCT03767738 Phase 4 Intravitreal Aflibercept Injection (IAI)
2 To Compare Intravitreal Clindamycin & Dexamethasone With Classic Treatment of Toxoplasmic Retinochoroiditis Unknown status NCT00372294 Phase 3 pyrimethamine-sulfadiazine + prednisolone;Clindamycin+Dexamethasone
3 Influence of Trimethoprim-sulfamethoxazole for the Recurrence of Retinochoroiditis Toxoplasma Gondii Completed NCT01449877 Phase 3 Trimethoprim-Sulfamethoxazole
4 A Pilot Study to Investigate the Effect of Phosphodiesterase Inhibitors on Chorioretinal Blood Flow Using Optical Coherence Tomography Angiography. Suspended NCT04052269 Phase 3 Sildenafil 100mg
5 Evaluation de la Spironolactone Dans le Traitement Des choriorétinites séreuses Centrales Non résolutives à Trois Mois Completed NCT01552044 Phase 1, Phase 2 Spironolactone;Placebo
6 Treatment of Exudative and Vasogenic Chorioretinal Diseases Including Variants of AMD and Other CNV Related Maculopathy With Intravitreal Injection of Lucentis (Ranibizumab Injection) Completed NCT00470977 Phase 1, Phase 2 ranibizumab injection (0.5 mg)
7 Optical Coherence Tomography Angiography in Vitreo and Chorioretinal Pathologies Under the Influence of Dark and Light Adaptation Unknown status NCT03390205
8 Measurement of the Oxygen Saturation in the Retinal Vessels With Oxymap Unknown status NCT02318641
9 Analysis of Retinochoroidal Vasculature in Underweight Women Using Optical Coherence Tomography Angiography Completed NCT04631978
10 Evaluation of Biological Biomarkers Diagnostic of Toxoplasmosis Uveitis Completed NCT02843438 Anti-toxoplasmosis treatment;Anti-inflammatory treatments
11 Collaborative Ocular Antiangiogenic Study of Ukraine. Multicentral, Open-label, Randomized, Prospective Study of Antiangiogenic Therapy of Choroidal Neovascularisation Associated With Central Chorioretinitis Recruiting NCT04245072
12 Prevalence of Ocular Manifestations in Inflammatory Rheumatic Diseases Active, not recruiting NCT03753893
13 Postnatal HCMV Infection in Very Preterm Infants. Implications on Acute and Chronic Morbidity, Growth and Neurodevelopmental Outcomes Part of the Study on "Nutrition, Growth and Development Among Very Preterm Infants". Withdrawn NCT01151462

Search NIH Clinical Center for Chorioretinitis

Cochrane evidence based reviews: chorioretinitis

Genetic Tests for Chorioretinitis

Anatomical Context for Chorioretinitis

MalaCards organs/tissues related to Chorioretinitis:

40
Eye, Retina, Bone Marrow, Spinal Cord, Endothelial, Whole Blood, Cortex

Publications for Chorioretinitis

Articles related to Chorioretinitis:

(show top 50) (show all 2182)
# Title Authors PMID Year
1
Constitutive and inflammatory mediator-regulated fractalkine expression in human ocular tissues and cultured cells. 61 54
12657599 2003
2
The importance of specific IgG and IgE autoantibodies to retinal S antigen, total serum IgE, and sCD23 levels in autoimmune and infectious uveitis. 61 54
10471975 1999
3
Humoral and cell-mediated immune response against human retinal antigens in relation to ocular onchocerciasis. 61 54
2378211 1990
4
Atypical unilateral multifocal choroiditis in a COVID-19 positive patient. 61
33623832 2021
5
Candida guilliermondii-induced chorioretinitis in a patient with eating disorder. 61
33214072 2021
6
Clinical profile and visual outcome of intraocular inflammation associated with cat-scratch disease in Japanese patients. 61
33797675 2021
7
Infectious Uveitis after Local Steroid and/or Methotrexate Injections at A Tertiary Referral Center in New Zealand: A Case Series. 61
33792480 2021
8
Optical coherence tomography findings in toxoplasma retinochoroiditis. 61
33595490 2021
9
Atypical toxoplasmic retinochoroiditis in patients with malignant hematological diseases. 61
32651033 2021
10
Treatment Strategy in Human Ocular Toxoplasmosis: Why Antibiotics Have Failed. 61
33807871 2021
11
Incidence of chorioretinitis and endophthalmitis in hospitalized patients with fungemia. 61
33686234 2021
12
Unilateral hypopyon associated acute syphilitic posterior placoid chorioretinitis: Unusual presentation leading to HIV diagnosis. 61
33779397 2021
13
Ocular Findings in Infants with Congenital Toxoplasmosis Following a Toxoplasmosis Outbreak. 61
33711379 2021
14
Posterior Subhyaloid Precipitates: 'KPs' of the Posterior Segment. 61
33734863 2021
15
[Branch retinal artery occlusion associated with toxoplasma retinochoroiditis: OCT-angiography findings]. 61
33190964 2021
16
CLINICAL UTILITY OF BETA-D-GLUCAN TESTING FOR ENDOGENOUS FUNGAL CHORIORETINITIS OR ENDOPHTHALMITIS. 61
32516224 2021
17
Ocular Toxoplasmosis after Exposure to Wild Game. 61
33560166 2021
18
Immunoglobulin fetal therapy and neonatal therapy with antiviral drugs improve neurological outcome of infants with symptomatic congenital cytomegalovirus infection. 61
33422744 2021
19
Ocular Co-infection with Mycobacterium Tuberculosis and Toxoplasma Gondii in an Immunocompetent Patient - A Case Report. 61
33544637 2021
20
The many faces of ocular syphilis: case-based update on recognition, diagnosis, and treatment. 61
33549544 2021
21
Prevalence and causes of clinically detectable uveitic serous retinal detachment. 61
33530714 2021
22
Bilateral ocular toxoplasmosis in a returning traveller: age and route of infection as potential risk factors. 61
33509864 2021
23
Host immune responses after suprachoroidal delivery of AAV8 in nonhuman primate eyes. 61
33446041 2021
24
Ocular Outcome of Brazilian Patients With Congenital Toxoplasmosis. 61
33060522 2021
25
Comparing the Results of Vitrectomy and Sclerectomy in a Patient with Nanophthalmic Uveal Effusion Syndrome. 61
33572746 2021
26
DIAGNOSIS THAT MIMIC PACHYCHOROID DISEASES OF MACULA - CASE REPORTS. 61
33740866 2021
27
Ocular Manifestations in Rheumatoid Arthritis, Connective Tissue Disease, and Vasculitis: A Systematic Review and Metaanalysis. 61
32358156 2021
28
Driving in Fog without Headlight: Management of a Challenging Case of Presumed Ocular Toxoplasmosis. 61
31577475 2021
29
Multimodal Imaging in AIDS-Related Ocular Cryptococcosis. 61
33628553 2021
30
Neurosyphilis cerebrospinal fluid findings in patients with ocular syphilis. 61
31647700 2021
31
Syphilitic retinitis presentations: punctate inner retinitis and posterior placoid chorioretinitis. 61
32875361 2021
32
Placoid lesions of the retina: progress in multimodal imaging and clinical perspective. 61
33468489 2021
33
Seroprevalence of low avidity anti-Toxoplasma IgG in pregnant women and its relationship with their age and contact with cats. 61
33612756 2020
34
Comment on: Long-term Results of Trimethoprim Sulfamethoxazole Versus Placebo to Reduce the Risk of Recurrent Toxoplasma gondii Retinochoroiditis. 61
33097176 2020
35
Reply to Comment on: Long-term Results of Trimethoprim Sulfamethoxazole Versus Placebo to Reduce the Risk of Recurrent Toxoplasma gondii Retinochoroiditis. 61
33097174 2020
36
Treatment of Acute Toxoplasmosis in Pregnancy: Influence in the Mother-to-Child Transmission. 61
32912728 2020
37
Infectious uveitis in immunodeficient HIV-negative patients: A retrospective study. 61
31435074 2020
38
Bartonella henselae Neuroretinitis: A Rare Coinfection in POEMS Syndrome. 61
33389938 2020
39
A Multiple Evanescent White Dot Syndrome-like Reaction to Concurrent Retinal Insults. 61
33348087 2020
40
Factors associated with ocular adverse event after immune checkpoint inhibitor treatment. 61
32556494 2020
41
Peripheral Capillary Non-perfusion in Birdshot Retinochoroiditis: A Novel Finding on Ultra-widefield Fluorescein Angiography. 61
32469666 2020
42
Comparison between the areas of scarred and active toxoplasmic retinochoroiditis. 61
33235345 2020
43
Evaluation of fluocinolone acetonide 0.19 mg intravitreal implant in the management of birdshot retinochoroiditis. 61
33243833 2020
44
The Experimental Role of Medicinal Plants in Treatment of Toxoplasma gondii Infection: A Systematic Review. 61
33159263 2020
45
Multimodal Imaging in Ocular Toxoplasmosis. 61
32160073 2020
46
Ophthalmic and Neuro-ophthalmic Manifestations of Coronavirus Disease 2019 (COVID-19). 61
33021422 2020
47
The congenital toxoplasmosis burden in Brazil: Systematic review and meta-analysis. 61
32615081 2020
48
Clinical and Multimodal Imaging Findings and Risk Factors for Ocular Involvement in a Presumed Waterborne Toxoplasmosis Outbreak, Brazil1. 61
33219657 2020
49
Ocular Tuberculosis in HIV-infected Individuals. 61
32809898 2020
50
Ocular Manifestations of West Nile Virus. 61
33147758 2020

Variations for Chorioretinitis

Expression for Chorioretinitis

Search GEO for disease gene expression data for Chorioretinitis.

Pathways for Chorioretinitis

Pathways related to Chorioretinitis according to GeneCards Suite gene sharing:

(show top 50) (show all 70)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.07 VEGFA TNF NOD2 IL6 IL2 IL1B
2
Show member pathways
13.86 VEGFA TNF IL6 IL2 IL1B IL17A
3
Show member pathways
13.71 TNF IL6 IL2 IL1B IL17A IL10
4
Show member pathways
13.59 VEGFA TNF IL6 IL2 IL1B IL17A
5
Show member pathways
13.46 TNF IL6 IL2 IL1B IL17A IL10
6
Show member pathways
13.4 VEGFA TNF NOD2 IL6 IL2 IL1B
7
Show member pathways
13.36 TNF IL6 IL2 IL1B IL17A IL10
8
Show member pathways
13.25 TNF IL6 IL2 IL1B IL10 IFNG
9
Show member pathways
12.99 VEGFA TNF IL6 IL1B CX3CL1 CD4
10
Show member pathways
12.85 TNF IL6 IL2 IL1B IFNG
11
Show member pathways
12.76 VEGFA TNF IL6 IL2 IL1B IL17A
12
Show member pathways
12.68 TNF IL2 IL10 IFNG CD4
13
Show member pathways
12.65 TNF IL6 IL2 IL1B IL17A IL10
14 12.63 TNF IL2 IL1B IL17A IL10 IFNG
15
Show member pathways
12.6 TNF IL6 IL2 IL1B IL17A IL10
16
Show member pathways
12.56 TNF NOD2 IL6 IL2 IL1B IL17A
17
Show member pathways
12.44 IL6 IL2 IL10 IFNG
18
Show member pathways
12.42 TNF IL6 IL1B IL17A IFNG
19
Show member pathways
12.41 TNF IL6 IL2 IL10 CX3CL1
20
Show member pathways
12.41 TNF IL6 IL2 IL1B IFNG CRP
21 12.38 TNF IL6 IL2 CD4
22
Show member pathways
12.34 TNF IL6 IL1B IFNG
23
Show member pathways
12.33 TNF IL6 IL2 IL1B IL17A IL10
24 12.32 TNF NOD2 IL6 IL1B IL10 IFNG
25
Show member pathways
12.31 TNF IL6 IL2 IL1B IL10
26
Show member pathways
12.3 TNF IL1B IL10 IFNG
27 12.28 TNF NOD2 IL6 IL1B
28 12.28 VEGFA TNF IL6 IL1B IL10
29 12.24 VEGFA TNF IL6 IFNG
30
Show member pathways
12.23 TNF IL6 IL1B IFNG
31 12.15 VEGFA TNF IL1B IFNG
32 12.14 TNF IL6 IL2 IL1B IL10 CD8A
33 12.12 TNF IL6 IL2 IL1B IFNG
34
Show member pathways
12.09 IL2 IL1B IFNG CD8A CD4
35 12.08 TNF NOD2 IL6 IL1B CX3CL1
36 12.08 VEGFA TNF IL6 IL1B IL17A IL10
37 12.04 TNF IL6 IL2 IL10 IFNG CD8A
38 12.02 TNF IL6 IL1B IL10 IFNG
39 12 TNF IL6 IL1B CD8A CD4
40 11.99 VEGFA TNF IL6 IL1B
41 11.97 VEGFA TNF IL6 IL1B IL17A IFNG
42
Show member pathways
11.96 IL6 IL1B IL17A IFNG CD4
43 11.86 TNF IL6 IL1B IL10
44 11.83 IL6 IL2 IFNG
45
Show member pathways
11.79 TNF IL2 IFNG
46
Show member pathways
11.76 TNF IL2 IFNG CD8A
47 11.76 TNF IL2 IL1B IL17A IL10 IFNG
48
Show member pathways
11.75 VEGFA TNF IL6 IL2 IL1B IFNG
49 11.73 TNF IL6 IL10
50 11.71 TNF IL6 IL1B

GO Terms for Chorioretinitis

Cellular components related to Chorioretinitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.73 VEGFA TNF RBP3 IL6 IL2 IL1B
2 external side of plasma membrane GO:0009897 9.55 TNF IL17A CD8A CD4 ACE
3 extracellular region GO:0005576 9.47 VEGFA TNF RBP3 IL6 IL2 IL1B
4 photoreceptor outer segment GO:0001750 9.43 SAG CRB1 ABCA4

Biological processes related to Chorioretinitis according to GeneCards Suite gene sharing:

(show top 50) (show all 77)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.25 VEGFA TNF NOD2 IL6 IL2 IL17A
2 negative regulation of apoptotic process GO:0043066 10.15 VEGFA IL6 IL2 IL10 CX3CL1
3 positive regulation of gene expression GO:0010628 10.15 VEGFA TNF IL6 IL1B IFNG CRP
4 adaptive immune response GO:0002250 10.13 IL2 IL17A IFNG CD8A CD4
5 inflammatory response GO:0006954 10.09 TNF IL6 IL1B IL17A CX3CL1 CRP
6 positive regulation of cell proliferation GO:0008284 10.09 VEGFA NOD2 IL6 IL2 IL1B IFNG
7 cell-cell signaling GO:0007267 10.05 IL2 IL1B IL17A CX3CL1 CRB1
8 positive regulation of ERK1 and ERK2 cascade GO:0070374 10.03 VEGFA TNF NOD2 CX3CL1 CD4
9 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 10.01 TNF NOD2 CX3CL1 CD4
10 positive regulation of DNA-binding transcription factor activity GO:0051091 9.98 TNF IL6 IL1B IL10
11 cellular response to lipopolysaccharide GO:0071222 9.98 TNF NOD2 IL6 IL1B IL10
12 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.97 TNF NOD2 IL6 IL1B CX3CL1
13 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.96 VEGFA NOD2 IL6 CD4
14 positive regulation of tumor necrosis factor production GO:0032760 9.94 NOD2 IL6 IL17A IFNG
15 defense response to Gram-negative bacterium GO:0050829 9.93 IL6 IL17A CD4
16 positive regulation of JNK cascade GO:0046330 9.93 TNF NOD2 IL1B
17 negative regulation of tumor necrosis factor production GO:0032720 9.92 NOD2 IL10 CX3CL1
18 negative regulation of interleukin-6 production GO:0032715 9.92 TNF IL10 CX3CL1
19 cellular response to organic cyclic compound GO:0071407 9.92 TNF NOD2 IL1B
20 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.91 TNF NOD2 IL1B
21 response to glucocorticoid GO:0051384 9.91 TNF IL6 IL10
22 positive regulation of interferon-gamma production GO:0032729 9.91 TNF IL2 IL1B
23 regulation of insulin secretion GO:0050796 9.91 TNF IL6 IL1B IFNG
24 positive regulation of MAPK cascade GO:0043410 9.91 VEGFA NOD2 IL6 CX3CL1 CD4
25 positive regulation of protein phosphorylation GO:0001934 9.91 VEGFA TNF IL2 IL1B IFNG CD4
26 positive regulation of smooth muscle cell proliferation GO:0048661 9.9 TNF IL6 CX3CL1
27 positive regulation of MAP kinase activity GO:0043406 9.9 VEGFA TNF NOD2
28 humoral immune response GO:0006959 9.9 TNF IL6 IFNG
29 positive regulation of protein complex assembly GO:0031334 9.89 VEGFA TNF IFNG
30 positive regulation of cytokine production GO:0001819 9.89 TNF IL10 IFNG
31 positive regulation of T cell proliferation GO:0042102 9.89 IL6 IL2 IL1B CD4
32 positive regulation of nitric oxide biosynthetic process GO:0045429 9.88 TNF IL1B IFNG
33 defense response to Gram-positive bacterium GO:0050830 9.88 TNF NOD2 IL6 IL17A CRP
34 positive regulation of interleukin-12 production GO:0032735 9.87 NOD2 IL17A IFNG
35 positive regulation of chemokine production GO:0032722 9.87 TNF IL6 IFNG
36 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.87 TNF IL1B CX3CL1
37 positive regulation of JAK-STAT cascade GO:0046427 9.86 TNF IL6 IL10
38 microglial cell activation GO:0001774 9.86 TNF IFNG CX3CL1
39 positive regulation of interleukin-8 production GO:0032757 9.86 TNF NOD2 IL6 IL1B
40 positive regulation of inflammatory response GO:0050729 9.85 TNF IL2 IL1B IFNG CX3CL1
41 negative regulation of neurogenesis GO:0050768 9.84 TNF IL6 IL1B
42 positive regulation of osteoclast differentiation GO:0045672 9.84 TNF IL17A IFNG
43 macrophage differentiation GO:0030225 9.83 VEGFA IFNG CD4
44 positive regulation of phagocytosis GO:0050766 9.83 TNF NOD2 IL1B IFNG
45 positive regulation of immunoglobulin production GO:0002639 9.81 IL6 IL2 IL10
46 positive regulation of glial cell proliferation GO:0060252 9.8 TNF IL6 IL1B
47 positive regulation of interleukin-17 production GO:0032740 9.8 NOD2 IL6 IL2
48 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.78 TNF IL1B IFNG
49 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.77 TNF IL1B IL10
50 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.77 VEGFA TNF IL6 IL2 IFNG

Molecular functions related to Chorioretinitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.28 VEGFA TNF IL6 IL2 IL1B IL17A
2 growth factor activity GO:0008083 9.26 VEGFA IL6 IL2 IL10

Sources for Chorioretinitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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