MCID: CHR078
MIFTS: 50

Chorioretinitis

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Chorioretinitis

MalaCards integrated aliases for Chorioretinitis:

Name: Chorioretinitis 12 74 52 54 43 15 71
Retinochoroiditis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8886
ICD9CM 34 363.20
MeSH 43 D002825
NCIt 49 C110923
SNOMED-CT 67 46627006
ICD10 32 H30.9
UMLS 71 C0008513

Summaries for Chorioretinitis

MalaCards based summary : Chorioretinitis, also known as retinochoroiditis, is related to focal chorioretinitis and chorioretinal scar, and has symptoms including eye manifestations An important gene associated with Chorioretinitis is RBP3 (Retinol Binding Protein 3), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs leucovorin and Sulfadiazine have been mentioned in the context of this disorder. Affiliated tissues include retina, eye and testes, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia : 74 Chorioretinitis is an inflammation of the choroid (thin pigmented vascular coat of the eye) and retina... more...

Related Diseases for Chorioretinitis

Diseases related to Chorioretinitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1146)
# Related Disease Score Top Affiliating Genes
1 focal chorioretinitis 34.5 SAG CD40LG
2 chorioretinal scar 33.4 VEGFA CRB1 CD40LG
3 birdshot chorioretinopathy 33.1 RBP3 MRAP IL17A
4 congenital toxoplasmosis 32.1 IL10 DHFR CD8A CD40LG CD4
5 pars planitis 31.7 RBP3 MRAP IL2
6 neuroretinitis 31.6 SAG MRAP CD40LG CD4 ACE
7 multifocal choroiditis 31.1 TNF IL10
8 secondary syphilis 30.8 CD8A CD40LG CD4
9 vogt-koyanagi-harada disease 30.8 IL17A IL10 IFNG CD8A
10 asymptomatic neurosyphilis 30.8 CD40LG CD4
11 posterior uveitis 30.8 TNF SAG RBP3 MRAP IL6 IL2
12 cone-rod dystrophy 2 30.8 TNFRSF1B TNF SAG RBP3 IL6 IL2
13 punctate inner choroidopathy 30.8 TNF IL10
14 ocular toxoplasmosis 30.8 IL17A CD40LG
15 neurosyphilis 30.6 IL17A IL10
16 retinal detachment 30.5 VEGFA TNF IL6 IL10 IFNG
17 ocular tuberculosis 30.4 MRAP IFNG CD4 ACE
18 cat-scratch disease 30.4 CD40LG CD4 ACE
19 sympathetic ophthalmia 30.4 TNF RBP3 IL10
20 tertiary syphilis 30.4 CD8A CD40LG CD4
21 posterior scleritis 30.4 TNF MRAP ACE
22 retinal vein occlusion 30.4 VEGFA TNF IL6 CD40LG ACE
23 toxocariasis 30.3 MRAP IL10 CD40LG
24 toxoplasmosis 30.3 TNF IL6 IL10 IFNG DHFR CD40LG
25 scleritis 30.2 TNFRSF1B TNF MRAP IFNG
26 encephalitis 30.2 TNF IL6 IL10 CX3CL1 CD40LG
27 retinal vascular disease 30.2 VEGFA TNF IL6 ACE
28 latent syphilis 30.2 IFNG CD40LG CD4
29 acute retinal necrosis syndrome 30.2 MRAP CD8A CD40LG CD4
30 intermediate uveitis 30.1 TNF MRAP IL6 IL2 IL10 IFNG
31 onchocerciasis 30.1 SRCIN1 RBP3 IL2
32 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 30.1 IL17A IL10 IFNG
33 nocardiosis 30.1 TNFRSF1B TNF IFNG CD4
34 papilledema 30.1 VEGFA CD40LG CD4 ACE
35 chronic granulomatous disease 30.1 TNF IL17A IFNG CD40LG
36 sclerosing keratitis 30.1 SRCIN1 SAG RBP3
37 primary syphilis 30.1 CD40LG CD4
38 coccidioidomycosis 30.0 TNF IL17A CD40LG CD4
39 hantavirus pulmonary syndrome 30.0 VEGFA CD8A CD40LG
40 invasive aspergillosis 30.0 IL10 IFNG CD4
41 neuritis 30.0 TNF IL6 IL10 IFNG CX3CL1
42 lymphadenitis 30.0 TNF IL10 IFNG CD4
43 dengue disease 30.0 TNF CD8A CD40LG
44 optic neuritis 30.0 VEGFA TNF IL6 IL10
45 choroid disease 29.9 VEGFA RBP3 MRAP
46 choroiditis 29.9 VEGFA TNFRSF1B TNF SAG RBP3 MRAP
47 cytomegalovirus retinitis 29.9 TNF IL10 IFNG CD8A CD40LG CD4
48 endophthalmitis 29.9 VEGFA TNF SAG MRAP IL6 CD4
49 optic papillitis 29.9 TNFRSF1B RBP3 MRAP CD40LG CD4 ACE
50 subacute sclerosing panencephalitis 29.9 TNF IL6 IL2 IL10 IFNG

Graphical network of the top 20 diseases related to Chorioretinitis:



Diseases related to Chorioretinitis

Symptoms & Phenotypes for Chorioretinitis

UMLS symptoms related to Chorioretinitis:


eye manifestations

GenomeRNAi Phenotypes related to Chorioretinitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.36 CD40LG IL10 IL17A TNF
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.36 ACE IL10 IL17A IL2 TNF TNFRSF1B
3 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-3 9.36 DHFR

MGI Mouse Phenotypes related to Chorioretinitis:

45 (show all 17)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.4 ACE CD4 CD40LG CRB1 CX3CL1 DHFR
2 hematopoietic system MP:0005397 10.39 ACE CD4 CD40LG CD8A CRB1 CX3CL1
3 cardiovascular system MP:0005385 10.38 ACE CD40LG CRB1 CX3CL1 DHFR IFNG
4 endocrine/exocrine gland MP:0005379 10.38 ACE CD4 CD40LG CD8A CRB1 IFNG
5 cellular MP:0005384 10.37 CD4 CD40LG CD8A CRB1 CX3CL1 DHFR
6 immune system MP:0005387 10.35 ACE CD4 CD40LG CD8A CRB1 CX3CL1
7 growth/size/body region MP:0005378 10.3 ACE CD4 DHFR IFNG IL10 IL17A
8 mortality/aging MP:0010768 10.28 ACE CD4 CD40LG CD8A CRB1 DHFR
9 digestive/alimentary MP:0005381 10.2 CD4 IFNG IL10 IL17A IL2 IL6
10 integument MP:0010771 10.2 CD4 CD40LG CD8A DHFR IFNG IL10
11 nervous system MP:0003631 10.17 CD4 CD40LG CD8A CRB1 CX3CL1 IFNG
12 liver/biliary system MP:0005370 10.13 ACE DHFR IFNG IL10 IL2 IL6
13 neoplasm MP:0002006 9.97 ACE IFNG IL10 IL2 IL6 TNF
14 no phenotypic analysis MP:0003012 9.8 CD4 IFNG IL10 IL17A IL2 TNF
15 renal/urinary system MP:0005367 9.76 ACE CD40LG CD8A IFNG IL17A IL6
16 respiratory system MP:0005388 9.61 IFNG IL10 IL17A IL2 IL6 MRAP
17 vision/eye MP:0005391 9.32 CRB1 IFNG IL10 IL2 IL6 RBP3

Drugs & Therapeutics for Chorioretinitis

Drugs for Chorioretinitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 63)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
leucovorin Approved Phase 4 58-05-9 6006 143
2
Sulfadiazine Approved, Investigational, Vet_approved Phase 4 68-35-9 5215
3
Pyrimethamine Approved, Investigational, Vet_approved Phase 4 58-14-0 4993
4
Levoleucovorin Approved, Investigational Phase 4 68538-85-2
5
Spiramycin Approved Phase 4 24916-50-5
6
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
7 Folic Acid Antagonists Phase 4
8 Hormones Phase 4
9 Vitamin B Complex Phase 4
10 Folate Phase 4
11 Anti-Bacterial Agents Phase 4
12 Antiparasitic Agents Phase 4
13 Antiprotozoal Agents Phase 4
14 Vitamin B9 Phase 4
15 Antimalarials Phase 4
16 Micronutrients Phase 4
17 Antidotes Phase 4
18 Vitamins Phase 4
19 Nutrients Phase 4
20 Calcium, Dietary Phase 4
21 Trace Elements Phase 4
22 Protective Agents Phase 4
23
Calcium Nutraceutical Phase 4 7440-70-2 271
24
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
25
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
26
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
27
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
28
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
29
Clindamycin Approved, Vet_approved Phase 3 18323-44-9 29029
30
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
31 Prednisolone acetate Approved, Vet_approved Phase 3 52-21-1
32
Sulfamethoxazole Approved Phase 3 723-46-6 5329
33
Trimethoprim Approved, Vet_approved Phase 3 738-70-5 5578
34
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7
35 Gastrointestinal Agents Phase 3
36 Methylprednisolone Acetate Phase 3
37 Antineoplastic Agents, Hormonal Phase 3
38 Clindamycin phosphate Phase 3
39 Antiemetics Phase 3
40 Clindamycin palmitate Phase 3
41 glucocorticoids Phase 3
42 Cytochrome P-450 Enzyme Inhibitors Phase 3
43 Trimethoprim, Sulfamethoxazole Drug Combination Phase 3
44
tannic acid Approved Phase 2 1401-55-4
45
Benzocaine Approved, Investigational Phase 2 94-09-7, 1994-09-7 2337
46
Spironolactone Approved Phase 1, Phase 2 52-01-7, 1952-01-7 5833
47
Valganciclovir Approved, Investigational Phase 2 175865-60-8 64147
48 Hormone Antagonists Phase 1, Phase 2
49 Immunoglobulins Phase 2
50 Antibodies Phase 2

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 Phase IV Randomized Study of Pyrimethamine, Sulfadiazine, and Leucovorin Calcium for Congenital Toxoplasmosis Recruiting NCT00004317 Phase 4 Leucovorin calcium;Pyrimethamine;Spiramycin;Sulfadiazine
2 To Compare Intravitreal Clindamycin & Dexamethasone With Classic Treatment of Toxoplasmic Retinochoroiditis Unknown status NCT00372294 Phase 3 pyrimethamine-sulfadiazine + prednisolone;Clindamycin+Dexamethasone
3 Multicentre, Randomised Study to Determine the Relative Efficacy of Two Therapeutic Strategies in the Treatment of Children With Congenital Toxoplasmosis Unknown status NCT01202500 Phase 3
4 Influence of Trimethoprim-sulfamethoxazole for the Recurrence of Retinochoroiditis Toxoplasma Gondii Completed NCT01449877 Phase 3 Trimethoprim-Sulfamethoxazole
5 An Open-label Proof-of-concept Study With a Double-masked, Dose-ranging Component to Assess the Effects of AIN457 in Patients With Noninfectious Uveitis Completed NCT00685399 Phase 2 AIN457;AIN 457;AIN457
6 Evaluation de la Spironolactone Dans le Traitement Des choriorétinites séreuses Centrales Non résolutives à Trois Mois Completed NCT01552044 Phase 1, Phase 2 Spironolactone;Placebo
7 Valganciclovir for Suppression of HHV-8 Four Weeks Prior to Initiation of cART in Patients With Disseminated Kaposi Sarcoma Compare With Standard Therapy, Its Impact on the Development of IRIS and Attributable Mortality Active, not recruiting NCT03296553 Phase 2 Valganciclovir;Antiretroviral Combinations
8 Relevance of Gastric Aspirate in HCMV Detection Unknown status NCT03262194
9 Evaluation of Biological Biomarkers Diagnostic of Toxoplasmosis Uveitis Completed NCT02843438 Anti-toxoplasmosis treatment;Anti-inflammatory treatments
10 Study of the Choroidal Thickness Variations After Ingestion of RedBull® Energy Drink Completed NCT02856256
11 Screening for Congenital Cytomegalovirus Infection in Newborns With Failed Hearing Screen or Who Are Small for Gestational Age Completed NCT02683096
12 Cytomegalovirus Testing and Intervention Protocol for Newborn Nursery and Newborn Intensive Care Unit Completed NCT02680743
13 Collaborative Ocular Antiangiogenic Study of Ukraine. Multicentral, Open-label, Randomized, Prospective Study of Antiangiogenic Therapy of Choroidal Neovascularisation Associated With Central Chorioretinitis Recruiting NCT04245072
14 A Study for the Ocular Toxocariasis in the Patients Who Were Diagnosed With the Pulmonary Toxocariasis, and Ocular Toxocariasis Cohort: TOXOCARA Study Recruiting NCT03814837
15 Prevalence of Ocular Manifestations in Inflammatory Rheumatic Diseases Active, not recruiting NCT03753893
16 Postnatal HCMV Infection in Very Preterm Infants. Implications on Acute and Chronic Morbidity, Growth and Neurodevelopmental Outcomes Part of the Study on "Nutrition, Growth and Development Among Very Preterm Infants". Withdrawn NCT01151462

Search NIH Clinical Center for Chorioretinitis

Cochrane evidence based reviews: chorioretinitis

Genetic Tests for Chorioretinitis

Anatomical Context for Chorioretinitis

MalaCards organs/tissues related to Chorioretinitis:

40
Retina, Eye, Testes, Liver, Bone, Lung, Bone Marrow

Publications for Chorioretinitis

Articles related to Chorioretinitis:

(show top 50) (show all 2098)
# Title Authors PMID Year
1
Constitutive and inflammatory mediator-regulated fractalkine expression in human ocular tissues and cultured cells. 61 54
12657599 2003
2
The importance of specific IgG and IgE autoantibodies to retinal S antigen, total serum IgE, and sCD23 levels in autoimmune and infectious uveitis. 54 61
10471975 1999
3
Humoral and cell-mediated immune response against human retinal antigens in relation to ocular onchocerciasis. 54 61
2378211 1990
4
Optical coherence tomography angiography findings in macular toxoplasma retinochoroiditis: A case report. 61
32551402 2020
5
An unusual case of unilateral chorioretinitis and blind spot enlargement associated with asymptomatic West Nile virus infection. 61
32373759 2020
6
Transient mydriasis in toxoplasmosis retinochoroiditis. 61
32346651 2020
7
Factors associated with ocular adverse event after immune checkpoint inhibitor treatment. 61
32556494 2020
8
Characterization of Congenital Toxoplasmosis in Israel: A 17-year Nationwide Study Experience. 61
32398571 2020
9
General Features and Laboratory Diagnosis of Toxoplasma gondii Infection. 61
32482042 2020
10
Human Toxoplasma gondii infection in Nigeria: a systematic review and meta-analysis of data published between 1960 and 2019. 61
32505179 2020
11
CLINICAL UTILITY OF BETA-D-GLUCAN TESTING FOR ENDOGENOUS FUNGAL CHORIORETINITIS OR ENDOPHTHALMITIS. 61
32516224 2020
12
Severe Necrotising Toxoplasmic Retinochoroiditis in a Patient With Crohn's Disease in Use of Adalimumab and Azathioprine. 61
32415301 2020
13
Concurrent tuberculous chorioretinitis with choroidal neovascularization and tuberculous meningitis: a case report. 61
32532239 2020
14
Wide field swept source OCT angiography in acute syphilitic placoid chorioretinitis. 61
32274447 2020
15
[Ocular Syphilis - Update]. 61
32434244 2020
16
Multimodal imaging patterns of posterior syphilitic uveitis: a review of the literature, laboratory evaluation and treatment. 61
31927680 2020
17
Ocular manifestations in rheumatoid arthritis, connective tissue disease and vasculitis: a systematic review and meta-analysis. 61
32358156 2020
18
Study of onchocerciasis-related visual impairment in North Kivu province of the Democratic Republic of Congo in Africa. 61
32317473 2020
19
Psoriasis-associated progressive necrotizing posterior scleritis: A 6-year follow-up. 61
30638053 2020
20
Clinical profile of symptomatic congenital cytomegalovirus infection: cases from a tertiary hospital in north India. 61
32437297 2020
21
Peripheral Capillary Non-perfusion in Birdshot Retinochoroiditis: A Novel Finding on Ultra-widefield Fluorescein Angiography. 61
32469666 2020
22
Long-term Results of Trimethoprim-Sulfamethoxazole Versus Placebo to Reduce the Risk of Recurrent Toxoplasma gondii Retinochoroiditis. 61
31926883 2020
23
[Prevention of Recurrence of Ocular Toxoplasmosis - When? How? For Whom?] 61
32434243 2020
24
Spontaneous closure of macular hole in a case of toxoplasma retinochoroiditis. 61
32317485 2020
25
Blau syndrome following a bacterial infection. 61
32045678 2020
26
Congenital toxoplasmotic chorioretinitis following reinfection. 61
32536466 2020
27
Advanced Cases of Birdshot HLA-A29 Retinochoroiditis: Prevalence and Characteristics. 61
32330990 2020
28
Choroidal Manifestation of Systemic Non-Tuberculous Mycobacterial Infection: A Case Series. 61
32219781 2020
29
Syphilitic chorioretinitis presenting as a choroidal granuloma. 61
32265212 2020
30
Spectral Domain-Optical Coherence Tomography and Optical Coherence Tomography Angiography Findings in a Case of Acute Syphilitic Posterior Placoid Chorioretinitis. 61
32330987 2020
31
Evolving Longitudinal Retinal Observations in a Cohort of Survivors of Ebola Virus Disease. 61
32134433 2020
32
Multimodal ophthalmic imaging of staphylococcus aureus bacteremia associated with chorioretinitis, endocarditis, and multifocal brain abscesses. 61
31886435 2020
33
Management of Intraocular Infections in HIV. 61
32162992 2020
34
Mycobacterium chimaera chorioretinitis as a biomarker of systemic disease activity following nosocomial acquisition during cardiopulmonary bypass. 61
31766930 2020
35
Multimodal Imaging in Ocular Toxoplasmosis. 61
32160073 2020
36
[Neurological sequelae in patients with congenital cytomegalovirus]. 61
32111550 2020
37
Fifteen-minute consultation: Management of the infant born to a mother with toxoplasmosis in pregnancy. 61
32071105 2020
38
Congenital Toxoplasmosis Presenting as Eosinophilic Encephalomyelitis With Spinal Cord Hemorrhage. 61
31941759 2020
39
Management of the neovascular choroidal membrane secondary to ocular toxoplasmosis. 61
31879139 2020
40
VITREOUS TREPONEMAL ANTIBODY AS A SUPPLEMENTARY TEST TO SEROLOGY FOR THE CONFIRMATION OF SYPHILITIC CHORIORETINITIS. 61
29176538 2020
41
Toxoplasmosis chorioretinitis mimicking acute retinal necrosis associated with local corticosteroid. 61
32514378 2020
42
Ocular side effects of antirheumatic medications: a qualitative review. 61
32154367 2020
43
Evaluation of clinically asymptomatic high risk infants with congenital cytomegalovirus infection. 61
31575999 2020
44
Ocular Alterations Associated with Primary Congenital Heart Disease - A Cross-sectional Study. 61
32549721 2020
45
Clinical Features of Ocular Syphilis: a Retrospective Clinical Study in an Italian Referral Centre. 61
32036734 2020
46
Clinical Spectrum of West Nile Virus Neuroinvasive Disease. 61
31839864 2020
47
Clinical and angiographic characterization of choroidal neovascularization in diabetic retinopathy. 61
31984769 2020
48
Ocular syphilis in an immunocompetent man. 61
32528847 2020
49
[The early diagnosis of congenital neuroinfections during ophthalmologic examination in children of the first months of life]. 61
32323936 2020
50
SPONTANEOUS IMPROVEMENT OF SYPHILIS CHORIORETINITIS: CASE REPORT AND REVIEW OF THE LITERATURE. 61
29176535 2020

Variations for Chorioretinitis

Expression for Chorioretinitis

Search GEO for disease gene expression data for Chorioretinitis.

Pathways for Chorioretinitis

Pathways related to Chorioretinitis according to GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.06 VEGFA TNFRSF1B TNF IL6 IL2 IL17A
2
Show member pathways
13.87 VEGFA TNFRSF1B TNF IL6 IL2 IL17A
3
Show member pathways
13.7 TNFRSF1B TNF IL6 IL2 IL17A IL10
4
Show member pathways
13.57 VEGFA TNFRSF1B TNF IL6 IL2 IL17A
5
Show member pathways
13.44 TNFRSF1B TNF IL6 IL2 IL17A IL10
6
Show member pathways
13.36 VEGFA TNFRSF1B TNF IL6 IL2 IL17A
7
Show member pathways
13.33 TNFRSF1B TNF IL6 IL2 IL17A IL10
8
Show member pathways
13.09 TNF IL6 IL2 IL10 IFNG ACE
9
Show member pathways
12.98 VEGFA TNFRSF1B TNF IL6 CX3CL1 CD4
10
Show member pathways
12.74 TNFRSF1B TNF IL6 IL2 CD40LG
11
Show member pathways
12.7 TNFRSF1B TNF IFNG CD40LG CD4
12
Show member pathways
12.7 VEGFA TNF IL6 IL2 IL17A IL10
13
Show member pathways
12.68 TNFRSF1B TNF IL2 IL10 IFNG CD40LG
14
Show member pathways
12.62 TNF IL6 IL2 IL17A IL10 IFNG
15
Show member pathways
12.6 TNF IL6 IL2 IL17A IL10 IFNG
16 12.57 TNFRSF1B TNF IL2 IL17A IL10 IFNG
17
Show member pathways
12.56 TNF IL6 IL2 IL17A IL10 IFNG
18
Show member pathways
12.38 TNF IL6 IL2 IFNG DHFR
19
Show member pathways
12.38 TNFRSF1B TNF IL6 IL2 IL10 CX3CL1
20 12.37 TNF IL6 IL2 CD4
21
Show member pathways
12.36 TNF IL6 IL17A IFNG
22
Show member pathways
12.32 TNF IL6 IL2 IL17A IL10 IFNG
23
Show member pathways
12.3 TNF IL10 IFNG CD40LG
24 12.28 TNF IL6 IL10 IFNG
25
Show member pathways
12.25 TNF IL6 IL2 IL10
26 12.23 VEGFA TNF IL6 IFNG
27 12.22 VEGFA TNF IL6 IL10
28 12.07 TNF IL6 IL2 IL10
29 12.07 TNF IL6 IL2 IFNG
30
Show member pathways
12.03 IL2 IFNG CD8A CD4
31 12.03 TNFRSF1B TNF IL6 CX3CL1
32 12.03 VEGFA TNFRSF1B TNF IL6 IL17A IL10
33 12.01 TNF IL6 IL2 IL10 IFNG CD8A
34 11.98 TNF IL6 IL10 IFNG
35 11.96 TNF IL6 CD8A CD4
36 11.92 VEGFA TNF IL6 IL17A IFNG
37
Show member pathways
11.91 IL6 IL17A IFNG CD4
38
Show member pathways
11.89 TNF IL6 IL2 IL17A IL10 IFNG
39
Show member pathways
11.83 TNFRSF1B TNF CD40LG
40 11.83 IL6 IL2 IFNG
41
Show member pathways
11.83 TNF IL2 IFNG CD40LG
42 11.79 TNF IL6 IL10
43
Show member pathways
11.77 TNFRSF1B TNF CD40LG
44
Show member pathways
11.72 TNF IL2 IFNG CD8A
45
Show member pathways
11.71 VEGFA TNF IL6 IL2 IFNG CD40LG
46 11.63 TNF IL6 IL2 IFNG
47 11.61 TNFRSF1B TNF IL6 IL10
48 11.61 TNF IL6 IL10 IFNG CD40LG
49
Show member pathways
11.6 TNFRSF1B TNF IFNG
50 11.6 TNF IL2 IL17A IL10 IFNG CD8A

GO Terms for Chorioretinitis

Cellular components related to Chorioretinitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.7 VEGFA TNF RBP3 IL6 IL2 IL17A
2 external side of plasma membrane GO:0009897 9.63 TNF IL17A CD8A CD40LG CD4 ACE
3 extracellular region GO:0005576 9.47 VEGFA TNFRSF1B TNF RBP3 IL6 IL2

Biological processes related to Chorioretinitis according to GeneCards Suite gene sharing:

(show all 44)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.21 VEGFA TNF IL6 IL2 IL17A IL10
2 negative regulation of apoptotic process GO:0043066 10.05 VEGFA IL6 IL2 IL10 CX3CL1 CD40LG
3 cell surface receptor signaling pathway GO:0007166 10 TNFRSF1B SAG IFNG CD8A CD4
4 cell-cell signaling GO:0007267 9.99 IL2 IL17A CX3CL1 CRB1
5 cellular response to lipopolysaccharide GO:0071222 9.95 TNFRSF1B TNF IL6 IL10
6 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.93 TNF IL6 CX3CL1 CD40LG
7 inflammatory response GO:0006954 9.91 TNFRSF1B TNF IL6 IL17A CX3CL1 CD40LG
8 response to glucocorticoid GO:0051384 9.85 TNF IL6 IL10
9 positive regulation of smooth muscle cell proliferation GO:0048661 9.84 TNF IL6 CX3CL1
10 humoral immune response GO:0006959 9.84 TNF IL6 IFNG
11 positive regulation of protein complex assembly GO:0031334 9.83 VEGFA TNF IFNG
12 extrinsic apoptotic signaling pathway GO:0097191 9.8 TNFRSF1B TNF IFNG
13 positive regulation of interleukin-6 secretion GO:2000778 9.79 TNF IL17A IFNG
14 positive regulation of inflammatory response GO:0050729 9.78 TNF IL2 IFNG CX3CL1
15 negative regulation of interleukin-6 production GO:0032715 9.77 TNF IL10 CX3CL1
16 positive regulation of protein phosphorylation GO:0001934 9.77 VEGFA TNF IL2 IFNG CD4
17 positive regulation of cytokine secretion GO:0050715 9.74 TNF IL10 IFNG
18 positive regulation of JAK-STAT cascade GO:0046427 9.73 TNF IL6 IL10
19 microglial cell activation GO:0001774 9.72 TNF IFNG CX3CL1
20 regulation of neuroinflammatory response GO:0150077 9.69 TNFRSF1B IL6
21 negative regulation of amyloid-beta clearance GO:1900222 9.69 TNF IFNG
22 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.69 TNF IL6 IL17A
23 positive regulation of MHC class II biosynthetic process GO:0045348 9.68 IL10 IFNG
24 negative regulation of lipid storage GO:0010888 9.68 TNF IL6
25 endothelial cell apoptotic process GO:0072577 9.68 TNF IL10
26 neutrophil mediated immunity GO:0002446 9.67 IL6 ACE
27 positive regulation of osteoclast differentiation GO:0045672 9.67 TNF IL17A IFNG
28 positive regulation of I-kappaB phosphorylation GO:1903721 9.66 TNF CX3CL1
29 negative regulation of cytokine production involved in immune response GO:0002719 9.65 TNF IL10
30 regulation of immunoglobulin secretion GO:0051023 9.64 TNF CD40LG
31 positive regulation of interleukin-23 production GO:0032747 9.64 IL17A IFNG
32 negative regulation of cytokine secretion involved in immune response GO:0002740 9.63 TNF IL10
33 macrophage differentiation GO:0030225 9.63 VEGFA IFNG CD4
34 positive regulation of peptidyl-tyrosine autophosphorylation GO:1900086 9.62 VEGFA ACE
35 positive regulation of T cell proliferation GO:0042102 9.62 IL6 IL2 CD40LG CD4
36 cytokine-mediated signaling pathway GO:0019221 9.61 VEGFA TNFRSF1B TNF IL6 IL2 IL17A
37 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.59 TNF IFNG
38 receptor biosynthetic process GO:0032800 9.58 TNF IL10
39 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.58 TNFRSF1B TNF IFNG
40 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.55 VEGFA TNF IL6 IL2 IFNG
41 positive regulation of vitamin D biosynthetic process GO:0060557 9.54 TNF IFNG
42 positive regulation of nitrogen compound metabolic process GO:0051173 9.52 TNF IFNG
43 positive regulation of interleukin-1 beta biosynthetic process GO:0050725 9.43 TNF IL17A IFNG
44 immune response GO:0006955 9.36 TNFRSF1B TNF IL6 IL2 IL17A IL10

Molecular functions related to Chorioretinitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.28 VEGFA TNF IL6 IL2 IL17A IL10
2 growth factor activity GO:0008083 9.26 VEGFA IL6 IL2 IL10

Sources for Chorioretinitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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