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MCID: CHR410
MIFTS: 37

Choroid Cancer

Categories: Cancer diseases, Eye diseases, Neuronal diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Choroid Cancer

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MalaCards integrated aliases for Choroid Cancer:

Name: Choroid Cancer 12 15 17
Malignant Tumor of the Choroid 12
Malignant Tumor of Choroid 12
Neoplasm of Choroid 12
Choroid Neoplasms 45
Choroid Neoplasm 12
Choroidal Tumor 12

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Eye diseases Neuronal diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Disease Ontology 12 DOID:12759
ICD9CM 36 190.6
MeSH 45 D002830
NCIt 51 C2949 C3566
SNOMED-CT 69 93755007
ICD10 34 C69.3
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Summaries for Choroid Cancer

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MalaCards based summary : Choroid Cancer, also known as malignant tumor of the choroid, is related to posterior scleritis and paraganglioma. An important gene associated with Choroid Cancer is SNRPE (Small Nuclear Ribonucleoprotein Polypeptide E), and among its related pathways/superpathways are Neuroscience and Spinal Cord Injury. Affiliated tissues include lung, pineal and eye, and related phenotypes are behavior/neurological and cellular

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Related Diseases for Choroid Cancer

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Diseases related to Choroid Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 169)
# Related Disease Score Top Affiliating Genes
1 posterior scleritis 30.3 OGG1 TNFRSF10A
2 paraganglioma 29.9 ENO2 NF1 SYP
3 immature cataract 10.5 NF1 NF2
4 neurofibrosarcoma 10.5 NF1 NF2
5 plexiform neurofibroma 10.5 NF1 NF2
6 malignant glandular tumor of peripheral nerve sheath 10.5 NF1 SYP
7 syringoma 10.5 GFAP VIM
8 primary hepatic neuroendocrine carcinoma 10.4 SYP VIM
9 neurofibromatosis, familial spinal 10.4 NF1 NF2
10 nodular ganglioneuroblastoma 10.4 ENO2 SYP
11 desmoplastic infantile ganglioglioma 10.4 GFAP SYP
12 extraventricular neurocytoma 10.4 GFAP SYP
13 gliofibroma 10.4 GFAP NF1
14 lung combined type small cell carcinoma 10.4 GFAP SYP
15 cellular ependymoma 10.4 GFAP SYP
16 malignant peritoneal mesothelioma 10.4 NF2 VIM
17 carotid body cancer 10.4 ENO2 SYP
18 acinar cell cystadenocarcinoma 10.4 SERPINA1 SYP
19 malignant sertoli cell tumor 10.4 ENO2 SYP
20 urinary bladder small cell neuroendocrine carcinoma 10.4 ENO2 SYP
21 cerebral convexity meningioma 10.4 GFAP NF2
22 parachordoma 10.4 GFAP VIM
23 intraventricular meningioma 10.4 GFAP NF2
24 auditory system cancer 10.4 ENO2 SYP
25 syringocystadenoma papilliferum 10.4 GFAP VIM
26 sinonasal undifferentiated carcinoma 10.4 ENO2 SYP
27 olfactory groove meningioma 10.4 NF2 SYP
28 papillary adenoma 10.4 OGG1 VIM
29 fibrous meningioma 10.4 NF2 VIM
30 cutaneous ganglioneuroma 10.4 ENO2 SYP
31 extrahepatic bile duct adenocarcinoma 10.4 ENO2 SYP
32 small cell carcinoma of the bladder 10.4 ENO2 SYP
33 bednar tumor 10.4 ENO2 VIM
34 sensory organ benign neoplasm 10.4 ENO2 SYP
35 neurofibroma 10.4 NF1 NF2 SYP
36 orbital cancer 10.4 ENO2 SYP
37 middle ear adenoma 10.4 ENO2 SYP
38 chiari malformation 10.4 GFAP SYP
39 epithelioid malignant peripheral nerve sheath tumor 10.4 ENO2 NF1
40 dysembryoplastic neuroepithelial tumor 10.3 GFAP SYP
41 cornea cancer 10.3 GFAP NF2
42 obstructive hydrocephalus 10.3 GFAP NF1 SYP
43 meningothelial meningioma 10.3 ENO2 NF2
44 intracranial cysts 10.3 ENO2 GFAP
45 chordoid meningioma 10.3 GFAP SYP VIM
46 geniculate herpes zoster 10.3 SERPINA1 TNFRSF10A
47 pulmonary large cell neuroendocrine carcinoma 10.3 ENO2 SYP
48 melanotic medulloblastoma 10.3 ENO2 GFAP
49 angiocentric glioma 10.3 GFAP SYP VIM
50 medulloepithelioma 10.3 GFAP SYP VIM

Graphical network of the top 20 diseases related to Choroid Cancer:



Diseases related to Choroid Cancer
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Symptoms & Phenotypes for Choroid Cancer

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MGI Mouse Phenotypes related to Choroid Cancer:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.14 ENO2 GFAP HPGDS NF1 NF2 NGFR
2 cellular MP:0005384 10.07 ENO2 GFAP HPGDS NF1 NGFR OGG1
3 immune system MP:0005387 10.02 GFAP HPGDS NF1 NF2 NGFR OGG1
4 nervous system MP:0003631 9.9 ENO2 GFAP HPGDS NF1 NF2 NGFR
5 neoplasm MP:0002006 9.8 HPGDS NF1 NF2 OGG1 TNFRSF10A TNFRSF1A
6 respiratory system MP:0005388 9.5 ENO2 NF1 NF2 NGFR TNFRSF1A TNFRSF1B
7 vision/eye MP:0005391 9.17 GFAP NF1 NF2 NGFR TNFRSF1A TNFRSF1B
Sources

Drugs & Therapeutics for Choroid Cancer

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Search Clinical Trials , NIH Clinical Center for Choroid Cancer

Cochrane evidence based reviews: choroid neoplasms

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Genetic Tests for Choroid Cancer

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Anatomical Context for Choroid Cancer

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MalaCards organs/tissues related to Choroid Cancer:

42
Lung, Pineal, Eye, Brain, Spinal Cord, Thyroid, Cerebellum
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Publications for Choroid Cancer

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Articles related to Choroid Cancer:

# Title Authors Year
1
Endogenous endophthalmitis caused by Cryptococcus neoformans Var. Gattii mimicking choroidal tumor: From positron-emission tomography/computed tomography to histopathology. ( 28643722 )
2017
2
Retinal and Choroidal Detachment in Antineutrophil Cytoplasmic Antibody-Associated Scleritis and Retinal Vasculitis Mimicking Choroidal Tumor. ( 28489623 )
2017
3
Nodular Posterior Scleritis Mimicking Choroidal Tumor in a Patient With Systemic Lupus Erythematous: A Case Report and Literature Review. ( 26692258 )
2016
4
Granulomatosis with polyangiitis presenting as a choroidal tumor. ( 25949841 )
2015
5
Giant nodular posterior scleritis mimicking choroidal tumor. ( 25390477 )
2007
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Variations for Choroid Cancer

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Expression for Choroid Cancer

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Search GEO for disease gene expression data for Choroid Cancer.
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Pathways for Choroid Cancer

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Pathways related to Choroid Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Neuroscience 4
11.7 CALCA ENO2 GFAP NF1 NF2 NGFR
2
Spinal Cord Injury 1
11.58 GFAP NGFR VIM
3
Neural Stem Cell Differentiation Pathways and Lineage-specific Markers 66
11.33 GFAP SYP VIM
4
Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway 23
Show member pathways
 11.2 NGFR TNFRSF1A TNFRSF1B
5
14-3-3 and Regulation of BAD Activity 65
10.64 NGFR TNFRSF1A TNFRSF1B
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GO Terms for Choroid Cancer

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Cellular components related to Choroid Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tumor necrosis factor receptor superfamily complex GO:0002947 8.62 TNFRSF1A TNFRSF1B

Biological processes related to Choroid Cancer according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cardiac muscle hypertrophy GO:0010614 9.49 TNFRSF1A TNFRSF1B
2 intermediate filament organization GO:0045109 9.48 GFAP VIM
3 astrocyte development GO:0014002 9.46 GFAP VIM
4 Bergmann glial cell differentiation GO:0060020 9.43 GFAP VIM
5 negative regulation of neuron projection development GO:0010977 9.4 GFAP VIM
6 aortic valve development GO:0003176 9.37 TNFRSF1A TNFRSF1B
7 negative regulation of extracellular matrix constituent secretion GO:0003332 9.32 TNFRSF1A TNFRSF1B
8 intermediate filament-based process GO:0045103 9.26 GFAP VIM
9 positive regulation of apoptotic process involved in morphogenesis GO:1902339 9.16 TNFRSF1A TNFRSF1B
10 pulmonary valve development GO:0003177 8.96 TNFRSF1A TNFRSF1B
11 extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 8.8 NF1 TNFRSF10A TNFRSF1A

Molecular functions related to Choroid Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tumor necrosis factor-activated receptor activity GO:0005031 9.16 TNFRSF1A TNFRSF1B
2 tumor necrosis factor binding GO:0043120 8.96 TNFRSF1A TNFRSF1B
3 death receptor activity GO:0005035 8.62 NGFR TNFRSF10A
4 protein binding GO:0005515 10.13 CALCA ENO2 GFAP HPGDS NF1 NF2
Sources

Sources for Choroid Cancer

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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