MCID: CHR410
MIFTS: 28

Choroid Cancer

Categories: Cancer diseases, Eye diseases

Aliases & Classifications for Choroid Cancer

MalaCards integrated aliases for Choroid Cancer:

Name: Choroid Cancer 12 15 17
Malignant Tumor of the Choroid 12
Malignant Tumor of Choroid 12
Neoplasm of Choroid 12
Choroid Neoplasms 43
Choroid Neoplasm 12
Choroidal Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12759
ICD9CM 34 190.6
MeSH 43 D002830
NCIt 49 C2949 C3566
SNOMED-CT 67 93755007
ICD10 32 C69.3
UMLS 71 C0008523 C0153630

Summaries for Choroid Cancer

MalaCards based summary : Choroid Cancer, also known as malignant tumor of the choroid, is related to melanoma, uveal and pulmonary aspergilloma. An important gene associated with Choroid Cancer is YIPF3 (Yip1 Domain Family Member 3), and among its related pathways/superpathways is Aryl Hydrocarbon Receptor. The drugs Immunologic Factors and Immunoconjugates have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and testes, and related phenotype is Increased viability with MLN4924 (a NAE inhibitor).

Related Diseases for Choroid Cancer

Diseases related to Choroid Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Related Disease Score Top Affiliating Genes
1 melanoma, uveal 29.6 VEGFA NF1 EIF1AX
2 pulmonary aspergilloma 10.3 VEGFA KRTAP1-3
3 rubeosis iridis 10.2 VEGFA FANCG
4 branch retinal artery occlusion 10.2 VEGFA FANCG
5 retinal artery occlusion 10.2 VEGFA FANCG
6 chorioretinal scar 10.2 VEGFA FANCG
7 hypertensive retinopathy 10.1 VEGFA FANCG
8 retinal detachment 10.1
9 central retinal artery occlusion 10.1 VEGFA FANCG
10 macular retinal edema 10.1 VEGFA FANCG
11 retinal vascular occlusion 10.1 VEGFA FANCG
12 cardiovascular cancer 10.0 VEGFA NF1
13 rift valley fever 10.0 IFITM2 GTF2H1
14 mucosal melanoma 10.0 VEGFA NF1
15 scleritis 9.9
16 cardiovascular organ benign neoplasm 9.9 VEGFA NF1
17 differentiated thyroid carcinoma 9.9 VEGFA EIF1AX
18 macular degeneration, age-related, 1 9.8
19 choroiditis 9.8
20 posterior scleritis 9.8
21 ocular melanoma 9.8
22 melanoma 9.8
23 endophthalmitis 9.8
24 vasculitis 9.8
25 hemangioma 9.8
26 accommodative spasm 9.8 IFITM2 CYLC1
27 anisometropia 9.7 IFITM2 CYLC1
28 cycloplegia 9.7 IFITM2 CYLC1
29 irregular astigmatism 9.7 IFITM2 CYLC1
30 astigmatism 9.7 IFITM2 CYLC1
31 breast cancer 9.7
32 hepatocellular carcinoma 9.7
33 pheochromocytoma 9.7
34 sarcoidosis 1 9.7
35 lung cancer 9.7
36 granulomatosis with polyangiitis 9.7
37 hydrops, lactic acidosis, and sideroblastic anemia 9.7
38 paraganglioma 9.7
39 adrenal gland pheochromocytoma 9.7
40 common cold 9.7
41 retinal vasculitis 9.7
42 papilledema 9.7
43 preretinal fibrosis 9.7
44 capillary hemangioma 9.7
45 pulmonary tuberculosis 9.7
46 adenocarcinoma 9.7
47 neurilemmoma 9.7
48 malignant choroid melanoma 9.7
49 cataract 9.7
50 skin melanoma 9.7

Graphical network of the top 20 diseases related to Choroid Cancer:



Diseases related to Choroid Cancer

Symptoms & Phenotypes for Choroid Cancer

GenomeRNAi Phenotypes related to Choroid Cancer according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 8.92 CYLC1 FANCG GTF2H1 RPA1

Drugs & Therapeutics for Choroid Cancer

Drugs for Choroid Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunologic Factors Phase 1
2 Immunoconjugates Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Collaborative Ocular Melanoma Study (COMS) Unknown status NCT00000124 Phase 3
2 A Phase 1, Open-label, Multicenter Study Evaluating the Safety and Tolerability, Biologic Activity, Pharmacodynamics, and Pharmacokinetics of Single and Repeated Escalating Intravitreal Doses of ICON-1 in Patients With Uveal Melanoma Who Are Planned to Undergo Enucleation or Brachytherapy Completed NCT02771340 Phase 1
3 Characterization of Small Choroidal Tumors Using Functional Optical Coherence Tomography Active, not recruiting NCT01955915
4 Validation of a Molecular Test for Predicting Metastasis in Patients With Uveal Melanoma Withdrawn NCT00406120

Search NIH Clinical Center for Choroid Cancer

Cochrane evidence based reviews: choroid neoplasms

Genetic Tests for Choroid Cancer

Anatomical Context for Choroid Cancer

MalaCards organs/tissues related to Choroid Cancer:

40
Eye, Brain, Testes, Lung, Thyroid, Adrenal Gland, Breast

Publications for Choroid Cancer

Articles related to Choroid Cancer:

# Title Authors PMID Year
1
[An analysis of the cause of misdiagnosis with ocular opportunistic infection]. 61
10437001 1997
2
Choroid plexus carcinoma. Case report. 61
8855084 1996
3
[Study of scleral perforations caused by choroid cancer]. 61
13472382 1957

Variations for Choroid Cancer

Expression for Choroid Cancer

Search GEO for disease gene expression data for Choroid Cancer.

Pathways for Choroid Cancer

Pathways related to Choroid Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.3 VEGFA NF1

GO Terms for Choroid Cancer

Biological processes related to Choroid Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 interstrand cross-link repair GO:0036297 9.48 RPA1 FANCG
2 nucleotide-excision repair GO:0006289 9.46 RPA1 GTF2H1
3 nucleotide-excision repair, DNA incision GO:0033683 9.43 RPA1 GTF2H1
4 ovarian follicle development GO:0001541 9.4 VEGFA FANCG
5 nucleotide-excision repair, DNA incision, 5'-to lesion GO:0006296 9.37 RPA1 GTF2H1
6 nucleotide-excision repair, preincision complex assembly GO:0006294 9.32 RPA1 GTF2H1
7 artery morphogenesis GO:0048844 9.26 VEGFA NF1
8 nucleotide-excision repair, DNA incision, 3'-to lesion GO:0006295 9.16 RPA1 GTF2H1
9 camera-type eye morphogenesis GO:0048593 8.96 VEGFA NF1
10 nucleotide-excision repair, preincision complex stabilization GO:0006293 8.62 RPA1 GTF2H1

Sources for Choroid Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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