MCID: CHR410
MIFTS: 35

Choroid Cancer

Categories: Cancer diseases, Eye diseases, Neuronal diseases

Aliases & Classifications for Choroid Cancer

MalaCards integrated aliases for Choroid Cancer:

Name: Choroid Cancer 12 15 17
Malignant Tumor of the Choroid 12
Malignant Tumor of Choroid 12
Neoplasm of Choroid 12
Choroid Neoplasms 45
Choroid Neoplasm 12
Choroidal Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12759
ICD9CM 36 190.6
MeSH 45 D002830
NCIt 51 C2949 C3566
SNOMED-CT 69 93755007
ICD10 34 C69.3

Summaries for Choroid Cancer

MalaCards based summary : Choroid Cancer, also known as malignant tumor of the choroid, is related to posterior scleritis and paraganglioma. An important gene associated with Choroid Cancer is SNRPE (Small Nuclear Ribonucleoprotein Polypeptide E), and among its related pathways/superpathways are Neuroscience and Spinal Cord Injury. Affiliated tissues include eye, and related phenotypes are cellular and behavior/neurological

Related Diseases for Choroid Cancer

Diseases related to Choroid Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 166)
# Related Disease Score Top Affiliating Genes
1 posterior scleritis 30.2 OGG1 TNFRSF10A
2 paraganglioma 29.8 ENO2 NF1 SYP
3 malignant glandular tumor of peripheral nerve sheath 10.5 NF1 SYP
4 chordoid glioma 10.4 GFAP NF2
5 neurofibromatosis, familial spinal 10.4 NF1 NF2
6 primary hepatic neuroendocrine carcinoma 10.4 SYP VIM
7 desmoplastic infantile ganglioglioma 10.4 GFAP SYP
8 extraventricular neurocytoma 10.4 GFAP SYP
9 gliofibroma 10.4 GFAP NF1
10 lung combined type small cell carcinoma 10.4 GFAP SYP
11 olfactory nerve neoplasm 10.4 ENO2 SYP
12 malignant teratoma 10.4 ENO2 SYP
13 malignant peritoneal mesothelioma 10.4 NF2 VIM
14 partial motor epilepsy 10.4 SMUG1 SYP
15 sternum cancer 10.4 SMUG1 VIM
16 cerebral convexity meningioma 10.4 GFAP NF2
17 gastrointestinal neuroendocrine tumor 10.4 SMUG1 SYP
18 intraventricular meningioma 10.4 GFAP NF2
19 carotid body cancer 10.4 ENO2 SYP
20 acinar cell cystadenocarcinoma 10.4 SERPINA1 SYP
21 tolosa-hunt syndrome 10.4 NF1 SMUG1
22 parachordoma 10.4 GFAP VIM
23 malignant sertoli cell tumor 10.4 ENO2 SYP
24 urinary bladder small cell neuroendocrine carcinoma 10.4 ENO2 SYP
25 microcystic meningioma 10.4 ENO2 GFAP
26 syringocystadenoma papilliferum 10.4 GFAP VIM
27 auditory system cancer 10.4 ENO2 SYP
28 neurofibroma 10.4 NF1 NF2 SYP
29 sinonasal undifferentiated carcinoma 10.4 ENO2 SYP
30 protoplasmic astrocytoma 10.3 GFAP SMUG1
31 fibrous meningioma 10.3 NF2 VIM
32 pancreatic somatostatinoma 10.3 ENO2 SYP
33 bednar tumor 10.3 ENO2 VIM
34 obstructive hydrocephalus 10.3 GFAP NF1 SYP
35 cutaneous ganglioneuroma 10.3 ENO2 SYP
36 papillary adenoma 10.3 OGG1 VIM
37 extrahepatic bile duct adenocarcinoma 10.3 ENO2 SYP
38 small cell carcinoma of the bladder 10.3 ENO2 SYP
39 olfactory groove meningioma 10.3 NF2 SYP
40 chordoid meningioma 10.3 GFAP SYP VIM
41 sensory organ benign neoplasm 10.3 ENO2 SYP
42 angiocentric glioma 10.3 GFAP SYP VIM
43 granulomatous myositis 10.3 SMUG1 TNFRSF1B
44 medulloepithelioma 10.3 GFAP SYP VIM
45 pilomyxoid astrocytoma 10.3 GFAP NF1 SYP
46 orbital cancer 10.3 ENO2 SYP
47 cellular schwannoma 10.3 NF1 NF2 NGFR
48 middle ear adenoma 10.3 ENO2 SYP
49 cornea cancer 10.3 GFAP NF2
50 intracranial cysts 10.3 ENO2 GFAP

Graphical network of the top 20 diseases related to Choroid Cancer:



Diseases related to Choroid Cancer

Symptoms & Phenotypes for Choroid Cancer

MGI Mouse Phenotypes related to Choroid Cancer:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.15 ENO2 ESCO2 GFAP HPGDS NF1 NGFR
2 behavior/neurological MP:0005386 10.14 ENO2 GFAP HPGDS NF1 NF2 NGFR
3 mortality/aging MP:0010768 10.03 ESCO2 GFAP HPGDS NF1 NF2 NGFR
4 immune system MP:0005387 10.02 GFAP HPGDS NF1 NF2 NGFR OGG1
5 neoplasm MP:0002006 9.76 HPGDS NF1 NF2 OGG1 SMUG1 TNFRSF10A
6 nervous system MP:0003631 9.73 ENO2 ESCO2 GFAP HPGDS NF1 NF2
7 respiratory system MP:0005388 9.17 ENO2 NF1 NF2 NGFR TNFRSF1A TNFRSF1B

Drugs & Therapeutics for Choroid Cancer

Search Clinical Trials , NIH Clinical Center for Choroid Cancer

Cochrane evidence based reviews: choroid neoplasms

Genetic Tests for Choroid Cancer

Anatomical Context for Choroid Cancer

MalaCards organs/tissues related to Choroid Cancer:

42
Eye

Publications for Choroid Cancer

Articles related to Choroid Cancer:

# Title Authors Year
1
Retinal and Choroidal Detachment in Antineutrophil Cytoplasmic Antibody-Associated Scleritis and Retinal Vasculitis Mimicking Choroidal Tumor. ( 28489623 )
2017
2
Endogenous endophthalmitis caused by Cryptococcus neoformans Var. Gattii mimicking choroidal tumor: From positron-emission tomography/computed tomography to histopathology. ( 28643722 )
2017
3
Nodular Posterior Scleritis Mimicking Choroidal Tumor in a Patient With Systemic Lupus Erythematous: A Case Report and Literature Review. ( 26692258 )
2015
4
Granulomatosis with polyangiitis presenting as a choroidal tumor. ( 25949841 )
2015
5
Giant nodular posterior scleritis mimicking choroidal tumor. ( 25390477 )
2007

Variations for Choroid Cancer

Expression for Choroid Cancer

Search GEO for disease gene expression data for Choroid Cancer.

Pathways for Choroid Cancer

GO Terms for Choroid Cancer

Cellular components related to Choroid Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tumor necrosis factor receptor superfamily complex GO:0002947 8.62 TNFRSF1A TNFRSF1B

Biological processes related to Choroid Cancer according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cardiac muscle hypertrophy GO:0010614 9.51 TNFRSF1A TNFRSF1B
2 intermediate filament organization GO:0045109 9.49 GFAP VIM
3 astrocyte development GO:0014002 9.48 GFAP VIM
4 Bergmann glial cell differentiation GO:0060020 9.46 GFAP VIM
5 depyrimidination GO:0045008 9.43 OGG1 SMUG1
6 negative regulation of neuron projection development GO:0010977 9.4 GFAP VIM
7 aortic valve development GO:0003176 9.37 TNFRSF1A TNFRSF1B
8 negative regulation of extracellular matrix constituent secretion GO:0003332 9.32 TNFRSF1A TNFRSF1B
9 intermediate filament-based process GO:0045103 9.26 GFAP VIM
10 positive regulation of apoptotic process involved in morphogenesis GO:1902339 9.16 TNFRSF1A TNFRSF1B
11 pulmonary valve development GO:0003177 8.96 TNFRSF1A TNFRSF1B
12 extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 8.8 NF1 TNFRSF10A TNFRSF1A

Molecular functions related to Choroid Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA N-glycosylase activity GO:0019104 9.26 OGG1 SMUG1
2 tumor necrosis factor-activated receptor activity GO:0005031 9.16 TNFRSF1A TNFRSF1B
3 tumor necrosis factor binding GO:0043120 8.96 TNFRSF1A TNFRSF1B
4 death receptor activity GO:0005035 8.62 NGFR TNFRSF10A

Sources for Choroid Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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