MCID: CHR573
MIFTS: 48

Choroid Plexus Cancer

Categories: Cancer diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Choroid Plexus Cancer

MalaCards integrated aliases for Choroid Plexus Cancer:

Name: Choroid Plexus Cancer 12 15 17
Choroid Plexus Carcinoma 12 20 29 6 44 15 70
Choroid Plexus Neoplasms 73 44 70
Tumor of the Choroid Plexus 12
Choroid Plexus Neoplasm 12
Tumor of Choroid Plexus 12
Choroid Plexus Tumors 54
Choroid Plexus Tumor 58

Classifications:

Orphanet: 58  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:3540 DOID:5648
UMLS via Orphanet 71 C0085138
Orphanet 58 ORPHA251896
UMLS 70 C0085138 C0346289 C0431109

Summaries for Choroid Plexus Cancer

GARD : 20 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs. Orpha Number: 251899 Definition Choroid plexus carcinoma is a rare and highly aggressive malignant type of choroid plexus tumor (see this term) occurring almost exclusively in children, presenting with cerebrospinal fluid obstruction in the lateral ventricles (most common), the fourth and third ventricles or in multiple ventricles, leading to hydrocephalus and increased intracranial pressure, and manifesting with nausea, vomiting, abnormal eye movements, gait impairment, seizures and enlarged head circumference.

MalaCards based summary : Choroid Plexus Cancer, also known as choroid plexus carcinoma, is related to rhabdoid tumor predisposition syndrome 1 and li-fraumeni syndrome, and has symptoms including vomiting and headache. An important gene associated with Choroid Plexus Cancer is TP53 (Tumor Protein P53), and among its related pathways/superpathways are BRCA1 Pathway and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Sargramostim and Lenograstim have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and spinal cord, and related phenotypes are Increased proliferation and vision/eye

Disease Ontology : 12 A choroid plexus cancer that has material basis in epithelial cells of the choroid plexus.

Wikipedia : 73 Choroid plexus papilloma, also known as papilloma of the choroid plexus, is a rare benign... more...

Related Diseases for Choroid Plexus Cancer

Diseases in the Choroid Plexus Cancer family:

Adult Choroid Plexus Cancer

Diseases related to Choroid Plexus Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 240)
# Related Disease Score Top Affiliating Genes
1 rhabdoid tumor predisposition syndrome 1 32.2 TP53 SMARCB1 ATRX
2 li-fraumeni syndrome 31.8 TP53 SMARCB1 ATRX
3 papilloma of choroid plexus 30.9 TTR TP53 SYP SMARCB1 KCNJ13 GFAP
4 monosomy 22 30.5 SMARCB1 CLDN6
5 papillary ependymoma 30.5 TTR SYP GFAP
6 anaplastic ependymoma 30.3 SYP GFAP
7 gangliocytoma 30.2 SYP GFAP
8 cellular ependymoma 30.2 ZFTA SYP GFAP
9 benign ependymoma 30.2 ZFTA SYP GFAP
10 secretory meningioma 30.1 SMARCB1 CEACAM5
11 medulloblastoma 30.0 TP53 SYP SMARCB1 SMARCA4 GFAP
12 rhabdoid meningioma 30.0 SYP SMARCB1 KCNJ13 GFAP
13 rhabdoid cancer 30.0 TP53 SYP SMARCB1 SMARCA4 CLDN6
14 hydrocephalus 30.0 TTR TP53 SYP SMARCB1 GFAP
15 brain cancer 30.0 TP53 SYP SMARCB1 GFAP
16 oligodendroglioma 30.0 TP53 SYP GFAP ATRX
17 meningioma, familial 30.0 TP53 SYP SMARCB1 GFAP
18 ependymoblastoma 29.9 SYP SMARCB1 GFAP FOXR2
19 pilocytic astrocytoma 29.7 TP53 SYP GFAP ATRX
20 rhabdomyosarcoma 29.7 TP53 SYP SMARCB1 SMARCA4 GFAP
21 teratoma 29.7 TP53 SYP SMARCB1 GFAP CEACAM5
22 central nervous system cancer 29.6 TP53 SYP SMARCB1 GFAP ATRX
23 atypical choroid plexus papilloma 29.4 TAF12 RAD54L NFYC KCNJ13 CCDC47 ACP3
24 atypical teratoid rhabdoid tumor 28.5 ZFTA TP53 SYP SMARCB1 SMARCA4 GFAP
25 li-fraumeni syndrome 2 11.3
26 adult choroid plexus cancer 11.3
27 childhood choroid plexus cancer 11.3
28 rhabdoid tumor predisposition syndrome 2 11.2
29 squamous cell papilloma 10.5
30 papilloma 10.5
31 rare tumor 10.5
32 urethra transitional cell carcinoma 10.4 TP53 GFAP
33 posterior pituitary gland neoplasm 10.4 SMARCB1 GFAP
34 intracranial hypertension 10.3
35 preretinal fibrosis 10.3 KCNJ13 GFAP
36 smarca4-deficient sarcoma of thorax 10.3 SMARCB1 SMARCA4
37 small-cell carcinoma of the ovary of hypercalcemic type 10.3 TP53 SMARCA4
38 myoepithelial carcinoma 10.3 TP53 SMARCB1 GFAP
39 extraventricular neurocytoma 10.3 SYP GFAP
40 desmoplastic infantile ganglioglioma 10.3 SYP GFAP
41 sarcomatoid transitional cell carcinoma 10.3 TP53 SYP
42 cerebral neuroblastoma 10.3 SYP GFAP
43 bile duct mucinous adenocarcinoma 10.3 TP53 SYP
44 lung combined type small cell carcinoma 10.3 SYP GFAP
45 juvenile type testicular granulosa cell tumor 10.3 SMARCB1 SMARCA4
46 optic nerve astrocytoma 10.3 SYP SMARCB1
47 testicular granulosa cell tumor 10.3 SMARCB1 SMARCA4
48 frontal lobe neoplasm 10.3 TP53 SYP
49 pineal region teratoma 10.3 SYP SMARCB1
50 cerebellopontine angle primitive neuroectodermal tumor 10.3 SYP GFAP

Graphical network of the top 20 diseases related to Choroid Plexus Cancer:



Diseases related to Choroid Plexus Cancer

Symptoms & Phenotypes for Choroid Plexus Cancer

UMLS symptoms related to Choroid Plexus Cancer:


vomiting; headache

GenomeRNAi Phenotypes related to Choroid Plexus Cancer according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased proliferation GR00094-A 8.62 SMARCB1 TP53

MGI Mouse Phenotypes related to Choroid Plexus Cancer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 vision/eye MP:0005391 9.28 ATRX GFAP RAD54L RTBDN SMARCA4 SMARCB1

Drugs & Therapeutics for Choroid Plexus Cancer

Drugs for Choroid Plexus Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 80)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sargramostim Approved, Investigational Phase 3 123774-72-1, 83869-56-1
2
Lenograstim Approved, Investigational Phase 3 135968-09-1
3
Etoposide Approved Phase 3 33419-42-0 36462
4
Vincristine Approved, Investigational Phase 3 2068-78-2, 57-22-7 5978
5
Carboplatin Approved Phase 3 41575-94-4 10339178 498142 38904
6
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
7
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
8
Irinotecan Approved, Investigational Phase 3 100286-90-6, 97682-44-5 60838
9
Cisplatin Approved Phase 3 15663-27-1 84093 441203 2767
10
Levoleucovorin Approved, Investigational Phase 3 68538-85-2 149436
11
Temozolomide Approved, Investigational Phase 3 85622-93-1 5394
12
Dactinomycin Approved, Investigational Phase 3 50-76-0 2019 457193
13
Doxorubicin Approved, Investigational Phase 3 23214-92-8 31703
14
leucovorin Approved Phase 3 58-05-9 6006
15
Folic acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
16 Immunologic Factors Phase 3
17 Adjuvants, Immunologic Phase 3
18 Alkylating Agents Phase 3
19 Tubulin Modulators Phase 3
20 Etoposide phosphate Phase 3
21 Immunosuppressive Agents Phase 3
22 Antirheumatic Agents Phase 3
23 Antimitotic Agents Phase 3
24 Vitamin B9 Phase 3
25 Folic Acid Antagonists Phase 3
26 Nutrients Phase 3
27 Antibiotics, Antitubercular Phase 3
28 topoisomerase I inhibitors Phase 3
29 Micronutrients Phase 3
30 Trace Elements Phase 3
31
Liposomal doxorubicin Phase 3 31703
32 Protective Agents Phase 3
33 Anti-Infective Agents Phase 3
34 Vitamin B Complex Phase 3
35 Vitamins Phase 3
36 Folate Phase 3
37 Antidotes Phase 3
38 Anti-Bacterial Agents Phase 3
39 Dermatologic Agents Phase 3
40 Antimetabolites Phase 3
41
Bevacizumab Approved, Investigational Phase 2 216974-75-3
42
nivolumab Approved Phase 2 946414-94-4
43
Topotecan Approved, Investigational Phase 2 123948-87-8, 119413-54-6 60700
44
Vinblastine Approved Phase 2 865-21-4 241903 13342
45 Angiogenesis Inhibitors Phase 2
46 Immunoglobulins, Intravenous Phase 2
47 Antibodies, Monoclonal Phase 2
48 Antineoplastic Agents, Immunological Phase 2
49 Antibodies Phase 2
50 Immunoglobulins Phase 2

Interventional clinical trials:

(show all 27)
# Name Status NCT ID Phase Drugs
1 Prospective and Randomized Study of Fixed Versus Flexible Prophylactic Administration of Granulocyte Colony-Stimulating Factor (G-CSF) in Children With Cancer Terminated NCT01987596 Phase 3
2 A Pilot Study Evaluating the Feasibility of an Intercontinental Phase III Chemotherapy Study for Patients With Choroid Plexus Tumors Terminated NCT00500890 Phase 3 Carboplatin;Cyclophosphamide;Etoposide;Vincristine
3 CPT-SIOP-2009: Intercontinental Multidisciplinary Registry and Treatment Optimization Study for Patients With Choroid Plexus Tumors Terminated NCT01014767 Phase 3 Carboplatin;Cisplatin;Cyclophosphamide;Dactinomycin;Doxorubicin;Etoposide;Irinotecan;Leucovorin;Methotrexate;Temozolomide;Vincristine
4 Phase II Trial of Irinotecan in Children With Refractory Solid Tumors Completed NCT00004078 Phase 2 irinotecan hydrochloride
5 A Randomized Phase II Trial of Bevacizumab to Control Brain Radiation Damage Completed NCT00492089 Phase 2 bevacizumab;placebo
6 Phase II Trial of the Immune Checkpoint Inhibitor Nivolumab in Patients With Recurrent Select Rare CNS Cancers Recruiting NCT03173950 Phase 2 Nivolumab
7 Risk-Adapted Therapy for Young Children With Embryonal Brain Tumors, Choroid Plexus Carcinoma, High Grade Glioma or Ependymoma Active, not recruiting NCT00602667 Phase 2 Induction Chemotherapy;Low-Risk Therapy;High-Risk Therapy;Intermediate-Risk Therapy
8 A PHASE 1 STUDY OF ISPINESIB (SB-715992) IN PEDIATRIC PATIENTS WITH RELAPSED OR REFRACTORY SOLID TUMORS Completed NCT00363272 Phase 1 ispinesib
9 A PHASE I STUDY OF DEPSIPEPTIDE (NSC#630176, IND# 51810) IN PEDIATRIC PATIENTS WITH REFRACTORY SOLID TUMORS AND LEUKEMIAS Completed NCT00053963 Phase 1 romidepsin
10 A Phase I Study of SAHA and Temozolomide in Children With Relapsed or Refractory Primary Brain or Spinal Cord Tumors Completed NCT01076530 Phase 1 vorinostat;temozolomide
11 A Phase I Trial of CC-5013 (Lenalidomide) in Pediatric Patients With Recurrent or Refractory Primary CNS Tumors Completed NCT00100880 Phase 1 lenalidomide
12 Phase I Trial of Temozolomide and O6-Benzylguanine in Pediatric Patients With Recurrent Brain Tumors Completed NCT00052780 Phase 1 O6-benzylguanine;temozolomide
13 Phase 1 Trial of RO4929097 in Combination With Standard Radiotherapy and Temozolomide for Newly Diagnosed Malignant Glioma: A Pharmacokinetic and Pharmacodynamic Study Completed NCT01119599 Phase 1 Gamma-Secretase Inhibitor RO4929097;Temozolomide
14 Phase I Study of Cilengitide (EMD 121974) in Children With Refractory Brain Tumors Completed NCT00063973 Phase 1 cilengitide
15 A Phase I Study of ABT-888, an Oral Inhibitor of Poly (ADP-Ribose) Polymerase and Temozolomide in Children With Recurrent/Refractory CNS Tumors Completed NCT00946335 Phase 1 veliparib;temozolomide
16 A Phase I Study of Vorinostat and Bortezomib in Children With Refractory or Recurrent Solid Tumors, Including CNS Tumors and Lymphomas Completed NCT00994500 Phase 1 vorinostat;bortezomib
17 A Phase I Trial of p28 (NSC745104), a Non-HDM2 Mediated Peptide Inhibitor of p53 Ubiquitination in Pediatric Patients With Recurrent or Progressive CNS Tumors Completed NCT01975116 Phase 1 azurin-derived cell-penetrating peptide p28
18 A First-in-human Phase I Single-agent Dose-escalation, Food Effect and Dose Expansion Study of Oral ONC206 in Recurrent and Rare Primary Central Nervous System Neoplasms Recruiting NCT04541082 Phase 1 ONC206
19 Phase I Study of CDK 4-6 Inhibitor PD-0332991 (Palbociclib; IBRANCE) in Children With Recurrent, Progressive or Refractory Central Nervous System Tumors Terminated NCT02255461 Phase 1 palbociclib isethionate
20 Microenvironment: Imaging/Implications in Brain Tumors; A Preliminary Investigation of the Biodistribution of [F-18]-EF5 in Patients With Brain Tumors Terminated NCT00110032 Phase 1 EF5
21 A PHASE 1/2 STUDY OF RO4929097, AN ORAL SMALL MOLECULE INHIBITOR OF GAMMA-SECRETASE, IN CHILDREN WITH RELAPSED/REFRACTORY SOLID OR CNS TUMORS, LYMPHOMA, OR T-CELL LEUKEMIA Terminated NCT01088763 Phase 1 gamma-secretase/Notch signalling pathway inhibitor RO4929097;dexamethasone
22 A Children's Oncology Group Protocol for Collecting and Banking Pediatric Brain Tumor Research Specimens Completed NCT00919750
23 Molecular and Histopathologic Characterization of Atypical Teratoid Rhabdoid Tumors, Choroid Plexus Carcinomas, Ependymomas, Medulloblastoma HGNET, CNS Embryonal Tumors and Gliomas of the Pediatric CNS Recruiting NCT00897286
24 Molecular-guided Therapy for the Treatment of Patients With Relapsed and Refractory Childhood Cancers Active, not recruiting NCT02162732
25 Dynamic Contrast Enhanced Steady State T1-Weighted Perfusion MRI (DCE MRI): Characterization of Intracranial Lesions Terminated NCT02967380 Gadobenate Dimeglumine;Gadobutrol
26 Yoga and Brain Cancer: A Feasibility Study Terminated NCT01234805
27 Efficacy of 68Ga-DOTATOC Positron Emission Tomography (PET) CT in Children and Young Adults With Brain Tumors Withdrawn NCT02194452

Search NIH Clinical Center for Choroid Plexus Cancer

Cochrane evidence based reviews: choroid plexus neoplasms

Genetic Tests for Choroid Plexus Cancer

Genetic tests related to Choroid Plexus Cancer:

# Genetic test Affiliating Genes
1 Choroid Plexus Carcinoma 29

Anatomical Context for Choroid Plexus Cancer

MalaCards organs/tissues related to Choroid Plexus Cancer:

40
Eye, Brain, Spinal Cord, Bone Marrow, Cerebellum

Publications for Choroid Plexus Cancer

Articles related to Choroid Plexus Cancer:

(show top 50) (show all 327)
# Title Authors PMID Year
1
Identification of a novel TP53 germline mutation E285V in a rare case of paediatric adrenocortical carcinoma and choroid plexus carcinoma. 61 6
18762572 2008
2
Clinicopathologic correlations in epithelial choroid plexus neoplasms: a study of 52 cases. 61 54
1703384 1990
3
A choroid plexus metastasis of a prostatic adenocarcinoma mimicking a choroid plexus carcinoma: A case report. 61
33675842 2021
4
Cerebellopontine Angle Primary Choroid Plexus Carcinoma Present in an Adult: Case Report and Literature Review. 61
33717766 2021
5
Molecular insights into malignant progression of atypical choroid plexus papilloma. 61
33608379 2021
6
Benefit of Static FET PET in Pretreated Pediatric Brain Tumor Patients with Equivocal Conventional MRI Results. 61
33598897 2021
7
Synchronous choroid plexus papilloma and Wilms tumor in a girl, disclosing a Li-Fraumeni syndrome. 61
33407742 2021
8
Pediatric atypical choroid plexus papilloma: Clinical features and diagnosis. 61
33203591 2021
9
Outcome and molecular analysis of young children with choroid plexus carcinoma treated with non-myeloablative therapy: results from the SJYC07 trial. 61
33506206 2021
10
A Unique Case of Cerebellar Choroid Plexus Carcinoma. 61
32998789 2020
11
Choroid Plexus Carcinoma with Hyaline Globules: An Uncommon Histological Finding. 61
32969735 2020
12
Late recurrence of choroid plexus carcinoma. 61
32409961 2020
13
Moderate-to-strong expression of FGFR3 and TP53 alterations in a subpopulation of choroid plexus tumors. 61
31660579 2020
14
Epigenetics impacts upon prognosis and clinical management of choroid plexus tumors. 61
32342334 2020
15
An update on the CNS manifestations of brain tumor polyposis syndromes. 61
31970492 2020
16
Choroid Plexus Carcinoma in Adults: Literature Review and First Report of a Location into the Third Ventricle. 61
31629149 2020
17
Subgroup-specific outcomes of children with malignant childhood brain tumors treated with an irradiation-sparing protocol. 61
31375903 2020
18
An Intraventricular Type of Chondroma: A Case Report. 61
30984997 2020
19
Structure-based design generated novel hydroxamic acid based preferential HDAC6 lead inhibitor with on-target cytotoxic activity against primary choroid plexus carcinoma. 61
31072216 2019
20
Next generation DNA sequencing of atypical choroid plexus papilloma of brain: Identification of novel mutations in a female patient by Ion Proton. 61
31612017 2019
21
DNA methylation signature is prognostic of choroid plexus tumor aggressiveness. 61
31409384 2019
22
Perinatal (fetal and neonatal) choroid plexus tumors: a review. 61
30953158 2019
23
Clinical spectrum of Li-Fraumeni syndrome/Li-Fraumeni-like syndrome in Brazilian individuals with the TP53 p.R337H mutation. 61
30974190 2019
24
Myc and Loss of p53 Cooperate to Drive Formation of Choroid Plexus Carcinoma. 61
30885981 2019
25
Management of choroid plexus tumors-an institutional experience. 61
30783805 2019
26
Choroid Plexus Carcinoma in Adults: Two Case Reports. 61
31062532 2019
27
Multimodality characteristics of multifocal choroid plexus carcinoma with bilateral calvarial defects in a dog. 61
30892784 2019
28
Intracranial Neoplasms in the First Year of Life: Results of a Third Cohort of Patients From a Single Institution. 61
29617945 2019
29
Management of Choroid Plexus Tumors in Infants and Young Children Up to 4 Years of Age: An Institutional Experience. 61
30261376 2019
30
Multiple High Grade Rhabdoid Papillary Meningiomas Mimicking Choroid Plexus Carcinoma: A Case Report. 61
31754365 2019
31
Transventricular Migration of Choroid Plexus Carcinoma Causing an Intraoperative Conundrum: A Case Report with a Review of the Literature. 61
31536979 2019
32
Clinical Features and Prognostic Risk Factors of Choroid Plexus Tumors in Children. 61
30539906 2018
33
Widely Metastatic Choroid Plexus Carcinoma Associated with Novel TP53 Somatic Mutation. 61
30099178 2018
34
Pediatric choroid plexus carcinoma: Biologically and clinically in need of new perspectives. 61
29528196 2018
35
Mice Expressing Myc in Neural Precursors Develop Choroid Plexus and Ciliary Body Tumors. 61
29545198 2018
36
Glomeruloid Microvascular Proliferation, Desmoplasia, and High Proliferative Index as Potential Indicators of High Grade Canine Choroid Plexus Tumors. 61
29402204 2018
37
Roles of the apparent diffusion coefficient and tumor volume in predicting tumor grade in patients with choroid plexus tumors. 61
29546484 2018
38
Establishing a Preclinical Multidisciplinary Board for Brain Tumors. 61
29301833 2018
39
Choroid plexus carcinoma with neuronal and glial differentiation in a 7-week-old male Sprague-Dawley rat. 61
29459500 2018
40
A new genetically engineered mouse model of choroid plexus carcinoma. 61
29339161 2018
41
Screening with whole-body magnetic resonance imaging in pediatric subjects with Li-Fraumeni syndrome: A single institution pilot study. 61
29077256 2018
42
Rare TP53 variant associated with Li-Fraumeni syndrome exhibits variable penetrance in a Saudi family. 61
30588330 2018
43
Revisiting tumor patterns and penetrance in germline TP53 mutation carriers: temporal phases of Li-Fraumeni syndrome. 61
29076966 2018
44
A Case of Giant Supratentorial Choroid Plexus Carcinoma in a Young Girl. 61
29320777 2018
45
Effect of Surgery, Adjuvant Therapy, and Other Prognostic Factors on Choroid Plexus Carcinoma: A Systematic Review and Individual Patient Data Analysis. 61
28939225 2017
46
Increasing genomic instability during cancer therapy in a patient with Li-Fraumeni syndrome. 61
29594232 2017
47
Successful Treatment of Recurrent Li-Fraumeni Syndrome-related Choroid Plexus Carcinoma. 61
28859040 2017
48
Marrow-ablative chemotherapy followed by tandem autologous hematopoietic cell transplantation in pediatric patients with malignant brain tumors. 61
28783147 2017
49
Successful multimodal treatment of a gigantic choroid plexus carcinoma (CPC) in an 8-year-old girl. 61
28889280 2017
50
Constitutional mosaicism of a de novo TP53 mutation in a patient with bilateral choroid plexus carcinoma. 61
29025599 2017

Variations for Choroid Plexus Cancer

ClinVar genetic disease variations for Choroid Plexus Cancer:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 NF2 NM_000268.4(NF2):c.575A>G (p.Tyr192Cys) SNV other 438777 rs1555993319 GRCh37: 22:30051641-30051641
GRCh38: 22:29655652-29655652
2 FOXO3 NM_001455.4(FOXO3):c.583A>T (p.Lys195Ter) SNV other 438763 rs1554209779 GRCh37: 6:108882994-108882994
GRCh38: 6:108561791-108561791
3 NSD1 NM_022455.4(NSD1):c.7147G>T (p.Gly2383Cys) SNV other 438779 rs1554207664 GRCh37: 5:176721516-176721516
GRCh38: 5:177294515-177294515
4 TP53 NM_000546.6(TP53):c.742C>T (p.Arg248Trp) SNV Pathogenic 12347 rs121912651 GRCh37: 17:7577539-7577539
GRCh38: 17:7674221-7674221
5 TP53 NM_000546.5(TP53):c.854A>T (p.Glu285Val) SNV Pathogenic 12384 rs121912667 GRCh37: 17:7577084-7577084
GRCh38: 17:7673766-7673766

Expression for Choroid Plexus Cancer

Search GEO for disease gene expression data for Choroid Plexus Cancer.

Pathways for Choroid Plexus Cancer

Pathways related to Choroid Plexus Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.05 TP53 SMARCB1 SMARCA4
2 10.7 SYP SMARCA4 GFAP

GO Terms for Choroid Plexus Cancer

Cellular components related to Choroid Plexus Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 SWI/SNF complex GO:0016514 9.16 SMARCB1 SMARCA4
2 nBAF complex GO:0071565 8.96 SMARCB1 SMARCA4
3 npBAF complex GO:0071564 8.62 SMARCB1 SMARCA4

Biological processes related to Choroid Plexus Cancer according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of DNA-binding transcription factor activity GO:0051091 9.65 TAF12 SMARCB1 SMARCA4
2 chromatin remodeling GO:0006338 9.58 SMARCB1 SMARCA4 ATRX
3 determination of adult lifespan GO:0008340 9.51 TP53 RAD54L
4 nucleosome disassembly GO:0006337 9.49 SMARCB1 SMARCA4
5 positive regulation by host of viral transcription GO:0043923 9.46 SMARCB1 SMARCA4
6 DNA damage response, signal transduction by p53 class mediator GO:0030330 9.43 TP53 ATRX
7 ER overload response GO:0006983 9.37 TP53 CCDC47
8 positive regulation of transcription of nucleolar large rRNA by RNA polymerase I GO:1901838 9.32 SMARCB1 SMARCA4
9 RNA polymerase I preinitiation complex assembly GO:0001188 9.26 SMARCB1 SMARCA4
10 DNA strand renaturation GO:0000733 9.16 TP53 RAD54L
11 purine nucleobase metabolic process GO:0006144 8.96 TTR ACP3
12 positive regulation of glucose mediated signaling pathway GO:1902661 8.62 SMARCB1 SMARCA4

Molecular functions related to Choroid Plexus Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA binding GO:0003677 9.92 TP53 TAF12 SMARCB1 SMARCA4 RAD54L NFYC
2 identical protein binding GO:0042802 9.91 TTR TP53 SYP GFAP CLDN6 CEACAM5
3 transcription factor binding GO:0008134 9.71 TP53 TAF12 SMARCA4 NFYC
4 p53 binding GO:0002039 9.33 TP53 SMARCB1 SMARCA4
5 Tat protein binding GO:0030957 9.26 SMARCB1 SMARCA4
6 RNA polymerase I CORE element sequence-specific DNA binding GO:0001164 8.96 SMARCB1 SMARCA4
7 DNA translocase activity GO:0015616 8.62 RAD54L ATRX

Sources for Choroid Plexus Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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