Chromium Allergic Contact Dermatitis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MalaCards based summary: Chromium Allergic Contact Dermatitis is related to allergic contact dermatitis and contact dermatitis. An important gene associated with Chromium Allergic Contact Dermatitis is CCL5 (C-C Motif Chemokine Ligand 5), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. Affiliated tissues include skin, and related phenotypes are no phenotypic analysis and digestive/alimentary

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Related Diseases for Chromium Allergic Contact Dermatitis

Diseases related to Chromium Allergic Contact Dermatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 408)

#	Related Disease	Score	Top Affiliating Genes
1	allergic contact dermatitis	28.6	IL5 IL4 IL2 IL17A IL13 IL10
2	contact dermatitis	28.6	IL5 IL4 IL2 IL17A IL13 IL10
3	dermatitis	28.6	IL5 IL4 IL2 IL17A IL13 IL10
4	aztreonam allergy	10.2	IL5 IL13
5	nickel allergic contact dermatitis	10.2	IL5 IL13
6	cefaclor allergy	10.1	IL5 IL13
7	loeffler syndrome	10.1	IL5 IL13
8	aspirin-induced respiratory disease	10.1	IL5 IL13
9	angiostrongyliasis	10.1	IL5 IL13
10	eosinophilic gastritis	10.1	IL5 IL13
11	chronic meningitis	10.1	IL5 IL13
12	paragonimiasis	10.1	IL5 IL13
13	chronic eosinophilic pneumonia	10.1	IL5 IL13
14	trichomoniasis	10.1	IL10 CCL5
15	vulvovaginitis	10.1	IL10 CCL5
16	griscelli syndrome, type 2	10.1	IL10 CCL5
17	myelitis	10.1	IL17A IL10
18	viral encephalitis	10.1	IL10 CCL5
19	enterobiasis	10.1	IL5 IL4
20	palladium allergic contact dermatitis	10.1	IL17A IL10
21	cercarial dermatitis	10.1	IL5 IL4
22	avian influenza	10.1	IL10 CCL5
23	kimura disease	10.1	IL5 IL4
24	neurosyphilis	10.0	IL17A IL10
25	trichuriasis	10.0	IL13 IL10
26	chemical colitis	10.0	IL17A IL10
27	hypopyon	10.0	IL17A IL10
28	subcutaneous mycosis	10.0	IL17A IL10
29	inflammatory diarrhea	10.0	IL17A IL10
30	iritis	10.0	IL17A IL10
31	crohn's colitis	10.0	IL17A IL10
32	good syndrome	10.0	IL17A IL10
33	vernal keratoconjunctivitis	10.0	IL4 IL13
34	neurodermatitis	10.0	IL4 IL13
35	cellulitis	10.0	IL5 IL17A
36	blepharoconjunctivitis	10.0	IL4 IL13
37	iridocyclitis	10.0	IL17A IL10
38	microscopic colitis	10.0	IL17A IL10
39	autoimmune glomerulonephritis	10.0	IL17A IL10
40	bacterial vaginosis	10.0	IL10 CCL5
41	urethritis	10.0	IL17A IL10
42	choroiditis	10.0	IL17A IL10
43	eczema herpeticum	10.0	IL4 IL13
44	periapical periodontitis	10.0	IL17A IL10
45	septic arthritis	10.0	IL17A IL10
46	giardiasis	10.0	IL17A IL10
47	scleritis	10.0	IL5 IL4
48	human cytomegalovirus infection	10.0	IL17A IL10
49	bronchopneumonia	10.0	IL17A IL10
50	invasive aspergillosis	10.0	IL17A IL10

Graphical network of the top 20 diseases related to Chromium Allergic Contact Dermatitis:

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Symptoms & Phenotypes for Chromium Allergic Contact Dermatitis

MGI Mouse Phenotypes related to Chromium Allergic Contact Dermatitis:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	no phenotypic analysis	MP:0003012	9.77	IL10 IL13 IL17A IL2 IL4
2	digestive/alimentary	MP:0005381	9.73	IL10 IL13 IL17A IL2 IL4 IL5
3	liver/biliary system	MP:0005370	9.72	IL10 IL17A IL2 IL4 IL5
4	immune system	MP:0005387	9.7	CCL5 IL10 IL13 IL17A IL2 IL4
5	respiratory system	MP:0005388	9.43	IL10 IL13 IL17A IL2 IL4 IL5
6	hematopoietic system	MP:0005397	9.17	CCL5 IL10 IL13 IL17A IL2 IL4

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Drugs & Therapeutics for Chromium Allergic Contact Dermatitis

Search Clinical Trials, NIH Clinical Center for Chromium Allergic Contact Dermatitis

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Genetic Tests for Chromium Allergic Contact Dermatitis

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Anatomical Context for Chromium Allergic Contact Dermatitis

Organs/tissues related to Chromium Allergic Contact Dermatitis:

MalaCards : Skin

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Publications for Chromium Allergic Contact Dermatitis

Articles related to Chromium Allergic Contact Dermatitis:

#	Title	Authors	PMID	Year
1	Cytokine detection for the diagnosis of chromium allergy. ⁶²	Martins LE...Reis VM	24173176	2013
2	Allergy-related disorders in the construction industry. ⁶²	Carino M...Foti C	24971193	2013
3	Hexavalent chromium in house dust--a comparison between an area with historic contamination from chromate production and background locations. ⁶²	Stern AH...Fan ZH	20692023	2010
4	Lymphocyte proliferation testing in chromium allergic contact dermatitis. ⁶²	Martins LE...Reis VM	18582233	2008

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Genes for Chromium Allergic Contact Dermatitis

Genes related to Chromium Allergic Contact Dermatitis (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CCL5	C-C Motif Chemokine Ligand 5	Protein Coding	4.12	DISEASES inferred ¹⁴
2	IL5	Interleukin 5	Protein Coding	4.05	DISEASES inferred ¹⁴
3	IL13	Interleukin 13	Protein Coding	3.93	DISEASES inferred ¹⁴
4	IL17A	Interleukin 17A	Protein Coding	3.63	DISEASES inferred ¹⁴
5	IL4	Interleukin 4	Protein Coding	3.61	DISEASES inferred ¹⁴
6	IL2	Interleukin 2	Protein Coding	3.54	DISEASES inferred ¹⁴
7	IL10	Interleukin 10	Protein Coding	3.36	DISEASES inferred ¹⁴

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Variations for Chromium Allergic Contact Dermatitis

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Expression for Chromium Allergic Contact Dermatitis

Search GEO for disease gene expression data for Chromium Allergic Contact Dermatitis.

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Pathways for Chromium Allergic Contact Dermatitis

Pathways related to Chromium Allergic Contact Dermatitis according to GeneCards Suite gene sharing:

(show all 42)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁶ Show member pathways Immune System ⁶⁶ Neutrophil degranulation ⁶⁶	13.73	CCL5 IL10 IL13 IL17A IL2 IL4
2	ERK Signaling ⁶⁴ Show member pathways ILK Signaling ⁶⁴ MAPK Signaling ⁶⁴ Molecular Mechanisms of Cancer ⁶⁴ Rho Family GTPases ⁶⁴	13.63	IL5 IL4 IL2 IL17A IL13 IL10
3	MIF Mediated Glucocorticoid Regulation ⁶⁴ Show member pathways all-trans-Retinoic Acid Signaling in Brain ⁶⁴ Endothelin-1 Signaling Pathway ⁶⁴ Glucocorticoid Receptor Signaling ⁶⁴ IL-6 Pathway ⁶⁴ MIF Regulation of Innate Immune Cells ⁶⁴ NFAT Signaling and Lymphocyte Interactions ⁶⁴ Overview of proinflammatory and profibrotic mediators ⁷⁴ PEDF Induced Signaling ⁶⁴ PGC1Alpha Pathway ⁶⁴ RAR-Gamma-RXR-Alpha Degradation ⁶⁴ STAT3 Pathway ⁶⁴	13.46	CCL5 IL10 IL13 IL17A IL2 IL4
4	TGF-Beta Pathway ⁶⁴ Show member pathways JAK-STAT Pathway ⁶⁴ JNK Pathway ⁶⁴ MAPK Family Pathway ⁶⁴ Regulation of eIF4 and p70S6K ⁶⁴ SOCS Pathway ⁶⁴	13.37	IL5 IL4 IL2 IL17A IL13 IL10
5	Akt Signaling ⁶⁴ Show member pathways p38 Signaling ⁶⁴ Tec Kinases Signaling ⁶⁴	13.23	IL5 IL4 IL2 IL17A IL13 IL10
6	Cytokine Signaling in Immune system ⁶⁶ Show member pathways Signaling by Interleukins ⁶⁶	13.13	IL5 IL4 IL2 IL17A IL13 IL10
7	PAK Pathway ⁶⁴ Show member pathways Antioxidant Action of Vitamin-C ⁶⁴ Epithelial Adherens Junctions ⁶⁴	13.11	IL5 IL4 IL2 IL17A IL13 IL10
8	Overview of interferons-mediated signaling pathway ⁷⁴ Show member pathways all-trans-Retinoic Acid Mediated Apoptosis ⁶⁴ Cytokine Network ⁶⁴ Immune response IFN alpha/beta signaling pathway ²² Interferon alpha/beta signaling ⁶⁶ Jak/STAT Signaling Pathway ⁶⁵ Regulation of IFNA/IFNB signaling ⁶⁶ Type III interferon signaling ⁷⁴	12.51	IL10 IL13 IL17A IL2 IL4 IL5
9	NF-kappaB Signaling ³	12.5	IL4 IL2 IL17A IL10 CCL5
10	Immune response IL-23 signaling pathway ²² Show member pathways Angiopoietin receptor Tie2-mediated signaling ⁶¹ Angiopoietin-TIE2 Signaling ⁶⁴ Development Angiopoietin - Tie2 signaling ²² Development PDGF signaling via STATs and NF-kB ²² IL23-mediated signaling events ⁶¹ Immune response IL-10 signaling pathway ²² RAC1/PAK1/p38/MMP2 pathway ⁷⁴	12.39	IL2 IL17A IL10
11	NF-kappaB Pathway ⁷⁰ Show member pathways Akt Pathway ⁷⁰ Apoptosis Pathway ⁷⁰	12.26	IL5 IL2 IL13
12	T-cell activation SARS-CoV-2 ⁷⁴ Show member pathways T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection ⁷⁴	12.06	IL5 IL4 IL2 IL17A IL10
13	Neuroinflammation and glutamatergic signaling ⁷⁴	11.98	IL4 IL13 IL10
14	Hematopoietic Stem Cells and Lineage-specific Markers ⁶⁵	11.98	IL5 IL4 IL2 IL10
15	Interleukin-4 and Interleukin-13 signaling ⁶⁶	11.93	IL4 IL17A IL13 IL10
16	MAPK Pathway ⁷⁰ Show member pathways Toll-like Receptor Pathway ⁷⁰	11.91	IL5 IL2 IL13
17	IL27-mediated signaling events ⁶¹ Show member pathways IL12 signaling pathway ⁶⁷ Th1 Differentiation ⁶⁵	11.83	IL2 IL17A IL10
18	Glucocorticoid receptor regulatory network ⁶¹	11.75	IL13 IL2 IL4 IL5
19	AP-1 transcription factor network ⁶¹	11.7	IL5 IL4 IL2 IL10
20	Extrafollicular B cell activation by SARS-CoV-2 ⁷⁴	11.67	IL4 IL2 IL10
21	Th17 cell differentiation pathway ⁷⁴	11.66	IL4 IL2 IL17A
22	Lung fibrosis ⁷⁴	11.65	IL5 IL4 IL13 CCL5
23	Calcineurin-regulated NFAT-dependent transcription in lymphocytes ⁶¹ Show member pathways Calcium signaling in the CD4+ TCR pathway ⁶¹	11.64	IL5 IL4 IL2
24	Allograft rejection ⁷⁴	11.6	IL5 IL4 IL2 IL17A IL13 IL10
25	IL4-mediated signaling events ⁶¹	11.58	IL5 IL4 IL10
26	Inflammatory bowel disease signaling ⁷⁴ Show member pathways Ulcerative colitis signaling ⁷⁴	11.57	IL5 IL4 IL2 IL13 IL10
27	THC Differentiation Pathway ⁶⁴	11.44	IL10 IL2 IL4
28	Th2 Differentiation ⁶⁵	11.43	IL5 IL4 IL2 IL13 IL10
29	SARS-CoV-2 innate immunity evasion and cell-specific immune response ⁷⁴	11.4	IL10 CCL5
30	Interactions between immune cells and microRNAs in tumor microenvironment ⁷⁴	11.37	IL4 CCL5
31	Interleukin-10 signaling ⁶⁶	11.35	IL10 CCL5
32	Innate Lymphoid Cells Differentiation ⁶⁵	11.34	IL5 IL4 IL2 IL17A IL13 IL10
33	Inflammatory response pathway ⁷⁴	11.32	IL5 IL4 IL2
34	Development and heterogeneity of the ILC family ⁷⁴	11.26	IL13 IL17A IL4 IL5
35	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁵ Show member pathways IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁵	11.23	IL2 IL10
36	Cytokines and inflammatory response ⁷⁴	11.18	IL10 IL13 IL2 IL4 IL5
37	IL12 signaling mediated by STAT4 ⁶¹	11.1	IL2 IL13
38	OX40 Pathway ⁶⁴	11.07	IL5 IL4 IL2 IL13 IL10
39	G-protein signaling_Rap2B regulation pathway ²²	10.88	IL5 IL4 IL2 IL17A IL13 IL10
40	Selective expression of chemokine receptors during T-cell polarization ⁷⁴	10.84	IL4 IL2
41	IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁵	10.83	IL5 IL4 IL13
42	Immune infiltration in pancreatic cancer ⁷⁴	10.53	IL5 IL4 IL2 IL17A IL13 IL10

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GO Terms for Chromium Allergic Contact Dermatitis

Cellular components related to Chromium Allergic Contact Dermatitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	9.8	IL5 IL4 IL2 IL17A IL13 IL10
2	extracellular space	GO:0005615	9.47	IL5 IL4 IL2 IL17A IL13 IL10

Biological processes related to Chromium Allergic Contact Dermatitis according to GeneCards Suite gene sharing:

(show all 20)

#	Name	GO ID	Score	Top Affiliating Genes
1	inflammatory response	GO:0006954	10.17	IL5 IL17A IL13 CCL5
2	negative regulation of inflammatory response	GO:0050728	9.92	IL4 IL2 IL13 IL10
3	microglial cell activation	GO:0001774	9.89	IL4 IL13
4	positive regulation of T cell proliferation	GO:0042102	9.89	IL4 IL2 CCL5
5	positive regulation of macrophage activation	GO:0043032	9.88	IL13 IL10
6	macrophage activation	GO:0042116	9.88	IL4 IL13
7	positive regulation of receptor signaling pathway via JAK-STAT	GO:0046427	9.88	IL5 IL10 CCL5
8	positive regulation of MHC class II biosynthetic process	GO:0045348	9.86	IL4 IL10
9	positive regulation of tyrosine phosphorylation of STAT protein	GO:0042531	9.86	CCL5 IL13 IL2 IL4
10	positive regulation of mast cell degranulation	GO:0043306	9.85	IL13 IL4
11	negative regulation of endothelial cell apoptotic process	GO:2000352	9.85	IL4 IL13 IL10
12	positive regulation of isotype switching to IgG isotypes	GO:0048304	9.84	IL4 IL2
13	negative regulation of T-helper 17 cell differentiation	GO:2000320	9.83	IL4 IL2
14	type 2 immune response	GO:0042092	9.81	IL4 IL10
15	regulation of isotype switching	GO:0045191	9.78	IL4 IL10
16	positive regulation of plasma cell differentiation	GO:1900100	9.76	IL10 IL2
17	positive regulation of B cell proliferation	GO:0030890	9.76	IL5 IL4 IL2 IL13
18	negative regulation of complement-dependent cytotoxicity	GO:1903660	9.73	IL13 IL4
19	positive regulation of immunoglobulin production	GO:0002639	9.56	IL5 IL2 IL13 IL10
20	immune response	GO:0006955	9.4	IL5 IL4 IL2 IL17A IL13 IL10

Molecular functions related to Chromium Allergic Contact Dermatitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	growth factor activity	GO:0008083	9.56	IL5 IL4 IL2 IL10
2	cytokine activity	GO:0005125	9.44	IL5 IL4 IL2 IL17A IL13 IL10
3	cytokine receptor binding	GO:0005126	9.16	IL4 IL13

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Sources for Chromium Allergic Contact Dermatitis

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: CHR679 MIFTS: 28	Chromium Allergic Contact Dermatitis Categories: Immune diseases, Skin diseases	Data Licensing For inquiries, contact: [email protected]
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