MCID: CHR679
MIFTS: 28

Chromium Allergic Contact Dermatitis

Categories: Immune diseases, Skin diseases
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Aliases & Classifications for Chromium Allergic Contact Dermatitis

MalaCards integrated aliases for Chromium Allergic Contact Dermatitis:

Name: Chromium Allergic Contact Dermatitis 11 14

Classifications:



External Ids:

Disease Ontology 11 DOID:0040056
ICD10 31 L23.0

Summaries for Chromium Allergic Contact Dermatitis

Disease Ontology: 11 An allergic contact dermatitis that has allergic trigger chromium atom.

MalaCards based summary: Chromium Allergic Contact Dermatitis is related to allergic contact dermatitis and contact dermatitis. An important gene associated with Chromium Allergic Contact Dermatitis is CCL5 (C-C Motif Chemokine Ligand 5), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. Affiliated tissues include skin, and related phenotypes are no phenotypic analysis and digestive/alimentary

Related Diseases for Chromium Allergic Contact Dermatitis

Diseases related to Chromium Allergic Contact Dermatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 408)
# Related Disease Score Top Affiliating Genes
1 allergic contact dermatitis 28.6 IL5 IL4 IL2 IL17A IL13 IL10
2 contact dermatitis 28.6 IL5 IL4 IL2 IL17A IL13 IL10
3 dermatitis 28.6 IL5 IL4 IL2 IL17A IL13 IL10
4 aztreonam allergy 10.2 IL5 IL13
5 nickel allergic contact dermatitis 10.2 IL5 IL13
6 cefaclor allergy 10.1 IL5 IL13
7 loeffler syndrome 10.1 IL5 IL13
8 aspirin-induced respiratory disease 10.1 IL5 IL13
9 angiostrongyliasis 10.1 IL5 IL13
10 eosinophilic gastritis 10.1 IL5 IL13
11 chronic meningitis 10.1 IL5 IL13
12 paragonimiasis 10.1 IL5 IL13
13 chronic eosinophilic pneumonia 10.1 IL5 IL13
14 trichomoniasis 10.1 IL10 CCL5
15 vulvovaginitis 10.1 IL10 CCL5
16 griscelli syndrome, type 2 10.1 IL10 CCL5
17 myelitis 10.1 IL17A IL10
18 viral encephalitis 10.1 IL10 CCL5
19 enterobiasis 10.1 IL5 IL4
20 palladium allergic contact dermatitis 10.1 IL17A IL10
21 cercarial dermatitis 10.1 IL5 IL4
22 avian influenza 10.1 IL10 CCL5
23 kimura disease 10.1 IL5 IL4
24 neurosyphilis 10.0 IL17A IL10
25 trichuriasis 10.0 IL13 IL10
26 chemical colitis 10.0 IL17A IL10
27 hypopyon 10.0 IL17A IL10
28 subcutaneous mycosis 10.0 IL17A IL10
29 inflammatory diarrhea 10.0 IL17A IL10
30 iritis 10.0 IL17A IL10
31 crohn's colitis 10.0 IL17A IL10
32 good syndrome 10.0 IL17A IL10
33 vernal keratoconjunctivitis 10.0 IL4 IL13
34 neurodermatitis 10.0 IL4 IL13
35 cellulitis 10.0 IL5 IL17A
36 blepharoconjunctivitis 10.0 IL4 IL13
37 iridocyclitis 10.0 IL17A IL10
38 microscopic colitis 10.0 IL17A IL10
39 autoimmune glomerulonephritis 10.0 IL17A IL10
40 bacterial vaginosis 10.0 IL10 CCL5
41 urethritis 10.0 IL17A IL10
42 choroiditis 10.0 IL17A IL10
43 eczema herpeticum 10.0 IL4 IL13
44 periapical periodontitis 10.0 IL17A IL10
45 septic arthritis 10.0 IL17A IL10
46 giardiasis 10.0 IL17A IL10
47 scleritis 10.0 IL5 IL4
48 human cytomegalovirus infection 10.0 IL17A IL10
49 bronchopneumonia 10.0 IL17A IL10
50 invasive aspergillosis 10.0 IL17A IL10

Graphical network of the top 20 diseases related to Chromium Allergic Contact Dermatitis:



Diseases related to Chromium Allergic Contact Dermatitis

Symptoms & Phenotypes for Chromium Allergic Contact Dermatitis

MGI Mouse Phenotypes related to Chromium Allergic Contact Dermatitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 no phenotypic analysis MP:0003012 9.77 IL10 IL13 IL17A IL2 IL4
2 digestive/alimentary MP:0005381 9.73 IL10 IL13 IL17A IL2 IL4 IL5
3 liver/biliary system MP:0005370 9.72 IL10 IL17A IL2 IL4 IL5
4 immune system MP:0005387 9.7 CCL5 IL10 IL13 IL17A IL2 IL4
5 respiratory system MP:0005388 9.43 IL10 IL13 IL17A IL2 IL4 IL5
6 hematopoietic system MP:0005397 9.17 CCL5 IL10 IL13 IL17A IL2 IL4

Drugs & Therapeutics for Chromium Allergic Contact Dermatitis

Search Clinical Trials, NIH Clinical Center for Chromium Allergic Contact Dermatitis

Genetic Tests for Chromium Allergic Contact Dermatitis

Anatomical Context for Chromium Allergic Contact Dermatitis

Organs/tissues related to Chromium Allergic Contact Dermatitis:

MalaCards : Skin

Publications for Chromium Allergic Contact Dermatitis

Articles related to Chromium Allergic Contact Dermatitis:

# Title Authors PMID Year
1
Cytokine detection for the diagnosis of chromium allergy. 62
24173176 2013
2
Allergy-related disorders in the construction industry. 62
24971193 2013
3
Hexavalent chromium in house dust--a comparison between an area with historic contamination from chromate production and background locations. 62
20692023 2010
4
Lymphocyte proliferation testing in chromium allergic contact dermatitis. 62
18582233 2008

Variations for Chromium Allergic Contact Dermatitis

Expression for Chromium Allergic Contact Dermatitis

Search GEO for disease gene expression data for Chromium Allergic Contact Dermatitis.

Pathways for Chromium Allergic Contact Dermatitis

Pathways related to Chromium Allergic Contact Dermatitis according to GeneCards Suite gene sharing:

(show all 42)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.73 CCL5 IL10 IL13 IL17A IL2 IL4
2
Show member pathways
13.63 IL5 IL4 IL2 IL17A IL13 IL10
3
Show member pathways
13.46 CCL5 IL10 IL13 IL17A IL2 IL4
4
Show member pathways
13.37 IL5 IL4 IL2 IL17A IL13 IL10
5
Show member pathways
13.23 IL5 IL4 IL2 IL17A IL13 IL10
6
Show member pathways
13.13 IL5 IL4 IL2 IL17A IL13 IL10
7
Show member pathways
13.11 IL5 IL4 IL2 IL17A IL13 IL10
8
Show member pathways
12.51 IL10 IL13 IL17A IL2 IL4 IL5
9 12.5 IL4 IL2 IL17A IL10 CCL5
10
Show member pathways
12.39 IL2 IL17A IL10
11
Show member pathways
12.26 IL5 IL2 IL13
12
Show member pathways
12.06 IL5 IL4 IL2 IL17A IL10
13 11.98 IL4 IL13 IL10
14 11.98 IL5 IL4 IL2 IL10
15 11.93 IL4 IL17A IL13 IL10
16
Show member pathways
11.91 IL5 IL2 IL13
17
Show member pathways
11.83 IL2 IL17A IL10
18 11.75 IL13 IL2 IL4 IL5
19 11.7 IL5 IL4 IL2 IL10
20 11.67 IL4 IL2 IL10
21 11.66 IL4 IL2 IL17A
22 11.65 IL5 IL4 IL13 CCL5
23
Show member pathways
11.64 IL5 IL4 IL2
24 11.6 IL5 IL4 IL2 IL17A IL13 IL10
25 11.58 IL5 IL4 IL10
26
Show member pathways
11.57 IL5 IL4 IL2 IL13 IL10
27 11.44 IL10 IL2 IL4
28 11.43 IL5 IL4 IL2 IL13 IL10
29 11.4 IL10 CCL5
30 11.37 IL4 CCL5
31 11.35 IL10 CCL5
32 11.34 IL5 IL4 IL2 IL17A IL13 IL10
33 11.32 IL5 IL4 IL2
34 11.26 IL13 IL17A IL4 IL5
35
Show member pathways
11.23 IL2 IL10
36 11.18 IL10 IL13 IL2 IL4 IL5
37 11.1 IL2 IL13
38 11.07 IL5 IL4 IL2 IL13 IL10
39 10.88 IL5 IL4 IL2 IL17A IL13 IL10
40 10.84 IL4 IL2
41 10.83 IL5 IL4 IL13
42 10.53 IL5 IL4 IL2 IL17A IL13 IL10

GO Terms for Chromium Allergic Contact Dermatitis

Cellular components related to Chromium Allergic Contact Dermatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.8 IL5 IL4 IL2 IL17A IL13 IL10
2 extracellular space GO:0005615 9.47 IL5 IL4 IL2 IL17A IL13 IL10

Biological processes related to Chromium Allergic Contact Dermatitis according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 10.17 IL5 IL17A IL13 CCL5
2 negative regulation of inflammatory response GO:0050728 9.92 IL4 IL2 IL13 IL10
3 microglial cell activation GO:0001774 9.89 IL4 IL13
4 positive regulation of T cell proliferation GO:0042102 9.89 IL4 IL2 CCL5
5 positive regulation of macrophage activation GO:0043032 9.88 IL13 IL10
6 macrophage activation GO:0042116 9.88 IL4 IL13
7 positive regulation of receptor signaling pathway via JAK-STAT GO:0046427 9.88 IL5 IL10 CCL5
8 positive regulation of MHC class II biosynthetic process GO:0045348 9.86 IL4 IL10
9 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.86 CCL5 IL13 IL2 IL4
10 positive regulation of mast cell degranulation GO:0043306 9.85 IL13 IL4
11 negative regulation of endothelial cell apoptotic process GO:2000352 9.85 IL4 IL13 IL10
12 positive regulation of isotype switching to IgG isotypes GO:0048304 9.84 IL4 IL2
13 negative regulation of T-helper 17 cell differentiation GO:2000320 9.83 IL4 IL2
14 type 2 immune response GO:0042092 9.81 IL4 IL10
15 regulation of isotype switching GO:0045191 9.78 IL4 IL10
16 positive regulation of plasma cell differentiation GO:1900100 9.76 IL10 IL2
17 positive regulation of B cell proliferation GO:0030890 9.76 IL5 IL4 IL2 IL13
18 negative regulation of complement-dependent cytotoxicity GO:1903660 9.73 IL13 IL4
19 positive regulation of immunoglobulin production GO:0002639 9.56 IL5 IL2 IL13 IL10
20 immune response GO:0006955 9.4 IL5 IL4 IL2 IL17A IL13 IL10

Molecular functions related to Chromium Allergic Contact Dermatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.56 IL5 IL4 IL2 IL10
2 cytokine activity GO:0005125 9.44 IL5 IL4 IL2 IL17A IL13 IL10
3 cytokine receptor binding GO:0005126 9.16 IL4 IL13

Sources for Chromium Allergic Contact Dermatitis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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