MCID: CHR031
MIFTS: 46

Chromoblastomycosis

Categories: Infectious diseases, Rare diseases, Skin diseases

Aliases & Classifications for Chromoblastomycosis

MalaCards integrated aliases for Chromoblastomycosis:

Name: Chromoblastomycosis 12 54 60 45 15 17 74
Chromomycosis 12 77 54 60
Mossy Foot Disease 12 74

Classifications:

Orphanet: 60  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:1562
ICD9CM 36 117.2
MeSH 45 D002862
SNOMED-CT 69 7255004
ICD10 34 B43.9
MESH via Orphanet 46 D002862
ICD10 via Orphanet 35 B43.0 B43.1 B43.2 more
UMLS via Orphanet 75 C0008582
Orphanet 60 ORPHA182

Summaries for Chromoblastomycosis

NIH Rare Diseases : 54 Chromoblastomycosis is a chronic fungal infection characterized by raised and crusted lesions which affect the skin and subcutaneous tissue. It most often occurs on the limbs, but can affect any area of the body. Chromoblastomycosis is caused by several fungi found in soil, wood, and decaying plant material. It usually enters the skin through a minor injury such as a splinter. It is most common in areas with tropical and subtropical climates. Treatment of chromoblastomycosis may include medications like itraconazole and flucytosine, cryotherapy, or surgery. 

MalaCards based summary : Chromoblastomycosis, also known as chromomycosis, is related to pulmonary disease, chronic obstructive and aspergillosis, and has symptoms including pruritus and symptoms. An important gene associated with Chromoblastomycosis is HLA-A (Major Histocompatibility Complex, Class I, A), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. Affiliated tissues include skin, bone and brain, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Disease Ontology : 12 A subcutaneous mycosis that is a chronic subcutaneous fungal infection, which presents as nodular or verrucoid, ulcerated, or crusted skin lesions on exposed areas of skin caused by Fonsecaea pedrosoi, Fonsecaea compacta, Cladophialophora carrionii or Phialophora verrucosa. Histological examination reveals muriform cells (with perpendicular septations) or thick walled, dark-colored, rounded forms (copper pennies) that are characteristic of this infection.

Wikipedia : 77 Chromoblastomycosis (also known as chromomycosis, cladosporiosis, Fonseca''s disease, Pedroso''s... more...

Related Diseases for Chromoblastomycosis

Diseases related to Chromoblastomycosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 114)
# Related Disease Score Top Affiliating Genes
1 pulmonary disease, chronic obstructive 29.7 CXCR3 MMP1 MMP9
2 aspergillosis 29.7 CLEC7A IL4
3 phaeohyphomycosis 10.3
4 sporotrichosis 10.3
5 squamous cell carcinoma 10.3
6 lobomycosis 10.2
7 stevens-johnson syndrome/toxic epidermal necrolysis 10.2 CXCR3 HLA-A
8 periodontosis 10.2 HLA-A MMP9
9 hematopoietic stem cell transplantation 10.2 CLEC7A HLA-A
10 corneal ulcer 10.2 CCR1 MMP9
11 spastic entropion 10.2 MMP1 MMP9
12 chronic actinic dermatitis 10.2 MMP1 MMP9
13 internal hemorrhoid 10.2 MMP1 MMP9
14 light chain deposition disease 10.2 MMP1 MMP9
15 adult astrocytic tumour 10.2 MMP1 MMP9
16 mycetoma 10.2
17 oral lichen planus 10.2 CXCR3 MMP1
18 odontogenic myxoma 10.2 MMP1 MMP9
19 pelvic organ prolapse 10.2 MMP1 MMP9
20 collagenous colitis 10.2 MMP1 MMP9
21 chronic venous insufficiency 10.2 MMP1 MMP9
22 venous insufficiency 10.1 MMP1 MMP9
23 hypertensive heart disease 10.1 MMP1 MMP9
24 preterm premature rupture of the membranes 10.1 MMP1 MMP9
25 aortic aneurysm, familial abdominal, 1 10.1 MMP1 MMP9
26 aphthous stomatitis 10.1 HLA-A IL4
27 spondyloarthropathy 10.1 HLA-A IL4
28 fungal keratitis 10.1 CLEC7A MMP9
29 eumycotic mycetoma 10.1
30 hansen's disease 10.1
31 pulmonary emphysema 10.1 MMP1 MMP9
32 transient hypogammaglobulinemia of infancy 10.1 CCR1 IL4
33 carotid stenosis 10.1 MMP1 MMP9
34 tropical spastic paraparesis 10.1 CXCR3 MMP9
35 bronchiolitis obliterans 10.1 CXCR3 MMP9
36 orofacial granulomatosis 10.1 CXCR3 IL4
37 secondary progressive multiple sclerosis 10.1 CXCR3 MMP9
38 lichen disease 10.1 CXCR3 IL4
39 carotid artery disease 10.1 MMP1 MMP9
40 proliferative glomerulonephritis 10.1 CXCR3 IL4
41 scleritis 10.1 IL4 MMP9
42 angiostrongyliasis 10.1 IL4 MMP9
43 eosinophilic meningitis 10.0 IL4 MMP9
44 lichen planus 10.0 CXCR3 IL4
45 vulvovaginal candidiasis 10.0 CLEC7A IL4
46 mitral valve disease 10.0 IL4 MMP1
47 leprosy 3 10.0
48 arthritis 10.0
49 lepromatous leprosy 10.0
50 blastomycosis 10.0

Graphical network of the top 20 diseases related to Chromoblastomycosis:



Diseases related to Chromoblastomycosis

Symptoms & Phenotypes for Chromoblastomycosis

UMLS symptoms related to Chromoblastomycosis:


pruritus, symptoms

GenomeRNAi Phenotypes related to Chromoblastomycosis according to GeneCards Suite gene sharing:

27 (show all 40)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-101 10.14 CLEC7A CCR1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-103 10.14 CLEC7A HLA-A
3 Increased shRNA abundance (Z-score > 2) GR00366-A-105 10.14 CCR1 CXCR3
4 Increased shRNA abundance (Z-score > 2) GR00366-A-107 10.14 CLEC7A
5 Increased shRNA abundance (Z-score > 2) GR00366-A-110 10.14 HLA-A
6 Increased shRNA abundance (Z-score > 2) GR00366-A-113 10.14 CCR1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-118 10.14 HLA-A
8 Increased shRNA abundance (Z-score > 2) GR00366-A-12 10.14 CLEC7A
9 Increased shRNA abundance (Z-score > 2) GR00366-A-120 10.14 CCR1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-128 10.14 CLEC7A
11 Increased shRNA abundance (Z-score > 2) GR00366-A-135 10.14 CLEC7A
12 Increased shRNA abundance (Z-score > 2) GR00366-A-143 10.14 CLEC7A
13 Increased shRNA abundance (Z-score > 2) GR00366-A-147 10.14 CLEC7A CCR1 CXCR3
14 Increased shRNA abundance (Z-score > 2) GR00366-A-149 10.14 CLEC7A
15 Increased shRNA abundance (Z-score > 2) GR00366-A-156 10.14 HLA-A
16 Increased shRNA abundance (Z-score > 2) GR00366-A-158 10.14 CLEC7A
17 Increased shRNA abundance (Z-score > 2) GR00366-A-164 10.14 CLEC7A
18 Increased shRNA abundance (Z-score > 2) GR00366-A-178 10.14 HLA-A
19 Increased shRNA abundance (Z-score > 2) GR00366-A-186 10.14 CLEC7A
20 Increased shRNA abundance (Z-score > 2) GR00366-A-19 10.14 HLA-A
21 Increased shRNA abundance (Z-score > 2) GR00366-A-192 10.14 CXCR3
22 Increased shRNA abundance (Z-score > 2) GR00366-A-195 10.14 CCR1
23 Increased shRNA abundance (Z-score > 2) GR00366-A-196 10.14 CCR1
24 Increased shRNA abundance (Z-score > 2) GR00366-A-202 10.14 CLEC7A
25 Increased shRNA abundance (Z-score > 2) GR00366-A-205 10.14 CLEC7A
26 Increased shRNA abundance (Z-score > 2) GR00366-A-214 10.14 CLEC7A
27 Increased shRNA abundance (Z-score > 2) GR00366-A-23 10.14 CXCR3
28 Increased shRNA abundance (Z-score > 2) GR00366-A-29 10.14 CLEC7A
29 Increased shRNA abundance (Z-score > 2) GR00366-A-30 10.14 CLEC7A
30 Increased shRNA abundance (Z-score > 2) GR00366-A-31 10.14 HLA-A
31 Increased shRNA abundance (Z-score > 2) GR00366-A-36 10.14 CCR1
32 Increased shRNA abundance (Z-score > 2) GR00366-A-57 10.14 CLEC7A
33 Increased shRNA abundance (Z-score > 2) GR00366-A-63 10.14 CCR1
34 Increased shRNA abundance (Z-score > 2) GR00366-A-65 10.14 CXCR3
35 Increased shRNA abundance (Z-score > 2) GR00366-A-7 10.14 HLA-A
36 Increased shRNA abundance (Z-score > 2) GR00366-A-74 10.14 HLA-A
37 Increased shRNA abundance (Z-score > 2) GR00366-A-79 10.14 CLEC7A
38 Increased shRNA abundance (Z-score > 2) GR00366-A-81 10.14 CXCR3
39 Increased shRNA abundance (Z-score > 2) GR00366-A-82 10.14 CCR1
40 Increased shRNA abundance (Z-score > 2) GR00366-A-9 10.14 CLEC7A CXCR3

MGI Mouse Phenotypes related to Chromoblastomycosis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.73 CARD9 CCR1 CLEC7A CXCR3 IL4 MMP9
2 homeostasis/metabolism MP:0005376 9.7 CARD9 CCR1 CLEC7A CXCR3 IL4 MMP1
3 immune system MP:0005387 9.5 CARD9 CCR1 CLEC7A CXCR3 IL4 MMP1
4 respiratory system MP:0005388 9.02 CCR1 CLEC7A CXCR3 IL4 MMP9

Drugs & Therapeutics for Chromoblastomycosis

Search Clinical Trials , NIH Clinical Center for Chromoblastomycosis

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: chromoblastomycosis

Genetic Tests for Chromoblastomycosis

Anatomical Context for Chromoblastomycosis

MalaCards organs/tissues related to Chromoblastomycosis:

42
Skin, Bone, Brain, Testes, Breast, T Cells, Lymph Node

Publications for Chromoblastomycosis

Articles related to Chromoblastomycosis:

(show top 50) (show all 586)
# Title Authors Year
1
Melanin: Quantification and protection against oxidative stress in chromoblastomycosis agents. ( 29669009 )
2019
2
Case Report: A Case of Chromoblastomycosis Caused by Fonsecaea pedrosoi in Vietnam. ( 29974323 )
2019
3
Chromoblastomycosis: an autochthonous case of a tropical disease. ( 30161267 )
2019
4
Cutaneous chromoblastomycosis effectively treated with local heat monotherapy. ( 30280420 )
2019
5
Exophiala psychrophila: A new agent of chromoblastomycosis. ( 30533349 )
2019
6
Dermoscopic features in nodular chromoblastomycosis. ( 30565211 )
2019
7
A Case of Chromoblastomycosis Caused by Fonsecaea Pedrosoi and Investigation of the Pathogenic Fungi. ( 30701405 )
2019
8
Successful treatment of chromoblastomycosis using ALA-PDT in a patient with leukopenia. ( 30769166 )
2019
9
Cutaneous Chromoblastomycosis: A Prototypal Case. ( 30789034 )
2019
10
Elbow Malformation with Osteoarthritis and Bone Destruction Caused by Chromoblastomycosis. ( 30955128 )
2019
11
First case of chromoblastomycosis due to Phoma insulana. ( 27726899 )
2018
12
Longitudinal melanonychia due to voriconazole therapy during treatment of chromoblastomycosis. ( 29030858 )
2018
13
Chromoblastomycosis in Taiwan: A report of 30 cases and a review of the literature. ( 29087525 )
2018
14
Successful treatment of chromoblastomycosis of 10-year duration due to Fonsecaea nubica. ( 29178398 )
2018
15
Transformation of Fonsecaea pedrosoi into sclerotic cells links to the refractoriness of experimental chromoblastomycosis in BALB/c mice via a mechanism involving a chitin-induced impairment of IFN-γ production. ( 29481557 )
2018
16
Differential distribution patterns of Fonsecaea agents of chromoblastomycosis, exemplified by the first case due to F. monophora from Argentina. ( 29552459 )
2018
17
Combination of Amphotericin B and Terbinafine against Melanized Fungi Associated with Chromoblastomycosis. ( 29581111 )
2018
18
From phaeohyphomycosis to disseminated chromoblastomycosis: A retrospective study of infections caused by dematiaceous fungi. ( 29656841 )
2018
19
Case Report: Successful Treatment of Chromoblastomycosis Caused by Fonsecaea monophora in a Patient with Psoriasis Using Itraconazole and Acitretin. ( 29785921 )
2018
20
First case of chronic cutaneous chromoblastomycosis by Rhinocladiella similis aquired in Europe. ( 29885020 )
2018
21
Chromoblastomycosis due to Cladosporium langeronii. Molecular diagnosis of an agent previously diagnosed as Fonsecaea pedrosoi. ( 29924243 )
2018
22
Molecular identification and antifungal susceptibility profiles of clinical strains of Fonsecaea spp. isolated from patients with chromoblastomycosis in Rio de Janeiro, Brazil. ( 30048450 )
2018
23
Uncommon presentation of chromoblastomycosis. ( 30063772 )
2018
24
Chromoblastomycosis: an etiological, epidemiological, clinical, diagnostic, and treatment update. ( 30066754 )
2018
25
Chromoblastomycosis: clinical experience and review of literature. ( 30113072 )
2018
26
An impressive case of chromoblastomycosis due to Fonsecaea pedrosoi in a patient with a long history of fungal infection. ( 30126716 )
2018
27
Identification of chromoblastomycosis agents by PCR based reverse line blot (PCR-RLB) hybridization assay. ( 30194974 )
2018
28
Chromoblastomycosis in immunosuppressed patients. ( 30257629 )
2018
29
In vitro susceptibility of chromoblastomycosis agents to antifungal drugs: A systematic review. ( 30266638 )
2018
30
A Model for Trans-Kingdom Pathogenicity in Fonsecaea Agents of Human Chromoblastomycosis. ( 30356683 )
2018
31
Chromoblastomycosis Caused by Fonsecaea nubica: First Report in Northern China and Literature Review. ( 30547378 )
2018
32
Chromoblastomycosis Caused by Phialophora verrucosa in a Costa Rican Child with Skin Sequelae due to Snake Bite. ( 30656078 )
2018
33
Squamous cell carcinoma arising from a chromomycosis lesion caused by Rhinocladiella aquaspersa with postsurgical recurrence of chromomycosis. ( 30310837 )
2018
34
Endobronchial Topical Amphotericin B Instillation for Pulmonary Chromomycosis After Lung Transplantation: A Case Report. ( 29661466 )
2018
35
Cutaneous chromomycosis caused by Arthrinium arundinis. ( 29682896 )
2018
36
Chromoblastomycosis. ( 27856522 )
2017
37
Molecular identification of chromoblastomycosis clinical isolates in Guangdong. ( 28053146 )
2017
38
Correction: Molecular Epidemiology of Agents of Human Chromoblastomycosis in Brazil with the Description of Two Novel Species. ( 28122015 )
2017
39
Severe Chromoblastomycosis-Like Cutaneous Infection Caused by Chrysosporium keratinophilum. ( 28179902 )
2017
40
Mycetoma-like chromoblastomycosis: a diagnostic dilemma. ( 28233299 )
2017
41
Squamous cell carcinoma in long-standing chromoblastomycosis. ( 28272060 )
2017
42
Modulation of the immune response by Fonsecaea pedrosoi morphotypes in the course of experimental chromoblastomycosis and their role on inflammatory response chronicity. ( 28355277 )
2017
43
Chromoblastomycosis caused by Rhinocladiella similis: Case report. ( 28458993 )
2017
44
Counterfeit Pennies: Distinguishing Chromoblastomycosis From Phaeohyphomycotic Infections. ( 28525909 )
2017
45
Chromoblastomycosis caused by Cladophialophora carrionii. ( 28540878 )
2017
46
Erratum: Molecular identification of chromoblastomycosis clinical isolates in Guangdong. ( 28541426 )
2017
47
Study on the organization of cellular elements in the granulomatous lesion caused by chromoblastomycosis. ( 28753235 )
2017
48
Chromoblastomycosis in India: Review of 169 cases. ( 28771470 )
2017
49
Chromoblastomycosis and sporotrichosis, two endemic but neglected fungal infections in Madagascar. ( 28847419 )
2017
50
Chromoblastomycosis: tissue modifications during itraconazole treatment. ( 28954095 )
2017

Variations for Chromoblastomycosis

Expression for Chromoblastomycosis

Search GEO for disease gene expression data for Chromoblastomycosis.

Pathways for Chromoblastomycosis

GO Terms for Chromoblastomycosis

Biological processes related to Chromoblastomycosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.54 CCR1 CLEC7A CXCR3
2 extracellular matrix disassembly GO:0022617 9.32 MMP1 MMP9
3 T cell activation GO:0042110 9.26 CLEC7A IL4
4 immune response GO:0006955 9.26 CCR1 CXCR3 HLA-A IL4
5 collagen catabolic process GO:0030574 9.16 MMP1 MMP9
6 cytokine-mediated signaling pathway GO:0019221 8.92 CCR1 IL4 MMP1 MMP9

Molecular functions related to Chromoblastomycosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine binding GO:0019956 9.26 CCR1 CXCR3
2 C-C chemokine binding GO:0019957 9.16 CCR1 CXCR3
3 C-C chemokine receptor activity GO:0016493 8.96 CCR1 CXCR3
4 chemokine receptor activity GO:0004950 8.62 CCR1 CXCR3

Sources for Chromoblastomycosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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