MCID: CHR031
MIFTS: 46

Chromoblastomycosis

Categories: Infectious diseases, Rare diseases, Skin diseases

Aliases & Classifications for Chromoblastomycosis

MalaCards integrated aliases for Chromoblastomycosis:

Name: Chromoblastomycosis 12 53 59 44 15 73
Chromomycosis 12 76 53 59
Mossy Foot Disease 12 73

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:1562
ICD10 33 B43.9
ICD9CM 35 117.2
MeSH 44 D002862
SNOMED-CT 68 7255004
Orphanet 59 ORPHA182
MESH via Orphanet 45 D002862
ICD10 via Orphanet 34 B43.1 B43.0 B43.2 more
UMLS via Orphanet 74 C0008582

Summaries for Chromoblastomycosis

NIH Rare Diseases : 53 Chromoblastomycosis is a chronic fungal infection characterized by raised and crusted lesions which affect the skin and subcutaneous tissue. It most often occurs on the limbs, but can affect any area of the body. Chromoblastomycosis is caused by several fungi found in soil, wood, and decaying plant material. It usually enters the skin through a minor injury such as a splinter. It is most common in areas with tropical and subtropical climates. Treatment of chromoblastomycosis may include medications like itraconazole and flucytosine, cryotherapy, or surgery. 

MalaCards based summary : Chromoblastomycosis, also known as chromomycosis, is related to septic arthritis and aspergillosis, and has symptoms including pruritus and symptoms. An important gene associated with Chromoblastomycosis is HLA-A (Major Histocompatibility Complex, Class I, A), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. Affiliated tissues include skin, brain and testes, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Disease Ontology : 12 A subcutaneous mycosis that is a chronic subcutaneous fungal infection, which presents as nodular or verrucoid, ulcerated, or crusted skin lesions on exposed areas of skin caused by Fonsecaea pedrosoi, Fonsecaea compacta, Cladophialophora carrionii or Phialophora verrucosa. Histological examination reveals muriform cells (with perpendicular septations) or thick walled, dark-colored, rounded forms (copper pennies) that are characteristic of this infection.

Wikipedia : 76 Chromoblastomycosis (also known as chromomycosis, cladosporiosis, Fonseca''s disease, Pedroso''s... more...

Related Diseases for Chromoblastomycosis

Diseases related to Chromoblastomycosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 109)
# Related Disease Score Top Affiliating Genes
1 septic arthritis 30.0 CXCR3 MMP1
2 aspergillosis 29.8 CLEC7A IL4
3 pulmonary disease, chronic obstructive 29.6 CXCR3 MMP1 MMP9
4 sporotrichosis 10.2
5 squamous cell carcinoma 10.2
6 phaeohyphomycosis 10.2
7 lobomycosis 10.2
8 htlv-1 associated myelopathy/tropical spastic paraparesis 10.2 CXCR3 HLA-A
9 mycetoma 10.1
10 stevens-johnson syndrome/toxic epidermal necrolysis 10.1 CXCR3 HLA-A
11 hematopoietic stem cell transplantation 10.1 CLEC7A HLA-A
12 aphthous stomatitis 10.1 HLA-A IL4
13 oral lichen planus 10.1 CXCR3 MMP1
14 transient hypogammaglobulinemia of infancy 10.1 CCR1 IL4
15 periodontosis 10.1 HLA-A MMP9
16 orofacial granulomatosis 10.1 CXCR3 IL4
17 corneal ulcer 10.1 CCR1 MMP9
18 lichen disease 10.1 CXCR3 IL4
19 spondyloarthropathy 10.1 HLA-A IL4
20 spastic entropion 10.1 MMP1 MMP9
21 chronic actinic dermatitis 10.1 MMP1 MMP9
22 internal hemorrhoid 10.1 MMP1 MMP9
23 proliferative glomerulonephritis 10.1 CXCR3 IL4
24 light chain deposition disease 10.1 MMP1 MMP9
25 adult astrocytic tumour 10.1 MMP1 MMP9
26 odontogenic myxoma 10.1 MMP1 MMP9
27 tropical spastic paraparesis 10.1 CXCR3 MMP9
28 collagenous colitis 10.1 MMP1 MMP9
29 vulvovaginal candidiasis 10.1 CLEC7A IL4
30 mitral valve disease 10.1 IL4 MMP1
31 chronic venous insufficiency 10.1 MMP1 MMP9
32 venous insufficiency 10.1 MMP1 MMP9
33 pelvic organ prolapse 10.1 MMP1 MMP9
34 aggressive periodontitis 10.1 IL4 MMP1
35 hypertensive heart disease 10.0 MMP1 MMP9
36 aortic aneurysm, familial thoracic 1 10.0 MMP1 MMP9
37 preterm premature rupture of the membranes 10.0 MMP1 MMP9
38 pneumothorax 10.0 MMP1 MMP9
39 autoimmune disease of central nervous system 10.0 CXCR3 IL4
40 scleritis 10.0 IL4 MMP9
41 fungal keratitis 10.0 CLEC7A MMP9
42 angiostrongyliasis 10.0 IL4 MMP9
43 rubella 10.0 HLA-A IL4
44 pulmonary emphysema 10.0 MMP1 MMP9
45 allergic contact dermatitis 10.0 CXCR3 IL4
46 eosinophilic meningitis 10.0 IL4 MMP9
47 carotid stenosis 10.0 MMP1 MMP9
48 contact dermatitis 10.0 CXCR3 IL4
49 bronchiolitis obliterans 10.0 CXCR3 MMP9
50 secondary progressive multiple sclerosis 10.0 CXCR3 MMP9

Graphical network of the top 20 diseases related to Chromoblastomycosis:



Diseases related to Chromoblastomycosis

Symptoms & Phenotypes for Chromoblastomycosis

UMLS symptoms related to Chromoblastomycosis:


pruritus, symptoms

GenomeRNAi Phenotypes related to Chromoblastomycosis according to GeneCards Suite gene sharing:

26 (show all 39)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-101 10.14 CLEC7A CCR1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-103 10.14 CLEC7A HLA-A
3 Increased shRNA abundance (Z-score > 2) GR00366-A-105 10.14 CCR1 CXCR3
4 Increased shRNA abundance (Z-score > 2) GR00366-A-107 10.14 CLEC7A
5 Increased shRNA abundance (Z-score > 2) GR00366-A-110 10.14 HLA-A
6 Increased shRNA abundance (Z-score > 2) GR00366-A-113 10.14 CCR1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-118 10.14 HLA-A
8 Increased shRNA abundance (Z-score > 2) GR00366-A-12 10.14 CLEC7A
9 Increased shRNA abundance (Z-score > 2) GR00366-A-120 10.14 CCR1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-128 10.14 CLEC7A
11 Increased shRNA abundance (Z-score > 2) GR00366-A-135 10.14 CLEC7A
12 Increased shRNA abundance (Z-score > 2) GR00366-A-143 10.14 CLEC7A
13 Increased shRNA abundance (Z-score > 2) GR00366-A-147 10.14 CLEC7A CCR1 CXCR3
14 Increased shRNA abundance (Z-score > 2) GR00366-A-149 10.14 CLEC7A
15 Increased shRNA abundance (Z-score > 2) GR00366-A-156 10.14 HLA-A
16 Increased shRNA abundance (Z-score > 2) GR00366-A-158 10.14 CLEC7A
17 Increased shRNA abundance (Z-score > 2) GR00366-A-164 10.14 CLEC7A
18 Increased shRNA abundance (Z-score > 2) GR00366-A-178 10.14 HLA-A
19 Increased shRNA abundance (Z-score > 2) GR00366-A-186 10.14 CLEC7A
20 Increased shRNA abundance (Z-score > 2) GR00366-A-19 10.14 HLA-A
21 Increased shRNA abundance (Z-score > 2) GR00366-A-192 10.14 CXCR3
22 Increased shRNA abundance (Z-score > 2) GR00366-A-195 10.14 CCR1
23 Increased shRNA abundance (Z-score > 2) GR00366-A-196 10.14 CCR1
24 Increased shRNA abundance (Z-score > 2) GR00366-A-202 10.14 CLEC7A
25 Increased shRNA abundance (Z-score > 2) GR00366-A-205 10.14 CLEC7A
26 Increased shRNA abundance (Z-score > 2) GR00366-A-214 10.14 CLEC7A
27 Increased shRNA abundance (Z-score > 2) GR00366-A-23 10.14 CXCR3
28 Increased shRNA abundance (Z-score > 2) GR00366-A-29 10.14 CLEC7A
29 Increased shRNA abundance (Z-score > 2) GR00366-A-30 10.14 CLEC7A
30 Increased shRNA abundance (Z-score > 2) GR00366-A-31 10.14 HLA-A
31 Increased shRNA abundance (Z-score > 2) GR00366-A-36 10.14 CCR1
32 Increased shRNA abundance (Z-score > 2) GR00366-A-57 10.14 CLEC7A
33 Increased shRNA abundance (Z-score > 2) GR00366-A-63 10.14 CCR1
34 Increased shRNA abundance (Z-score > 2) GR00366-A-7 10.14 HLA-A
35 Increased shRNA abundance (Z-score > 2) GR00366-A-74 10.14 HLA-A
36 Increased shRNA abundance (Z-score > 2) GR00366-A-79 10.14 CLEC7A
37 Increased shRNA abundance (Z-score > 2) GR00366-A-81 10.14 CXCR3
38 Increased shRNA abundance (Z-score > 2) GR00366-A-82 10.14 CCR1
39 Increased shRNA abundance (Z-score > 2) GR00366-A-9 10.14 CLEC7A CXCR3

MGI Mouse Phenotypes related to Chromoblastomycosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.73 CARD9 CCR1 CLEC7A CXCR3 IL4 MMP9
2 homeostasis/metabolism MP:0005376 9.7 CARD9 CCR1 CLEC7A CXCR3 IL4 MMP1
3 immune system MP:0005387 9.5 CARD9 CCR1 CLEC7A CXCR3 IL4 MMP1
4 respiratory system MP:0005388 9.02 CCR1 CLEC7A CXCR3 IL4 MMP9

Drugs & Therapeutics for Chromoblastomycosis

Search Clinical Trials , NIH Clinical Center for Chromoblastomycosis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: chromoblastomycosis

Genetic Tests for Chromoblastomycosis

Anatomical Context for Chromoblastomycosis

MalaCards organs/tissues related to Chromoblastomycosis:

41
Skin, Brain, Testes, T Cells, Liver, Bone, Heart

Publications for Chromoblastomycosis

Articles related to Chromoblastomycosis:

(show top 50) (show all 573)
# Title Authors Year
1
Exophiala psychrophila: A new agent of chromoblastomycosis. ( 30533349 )
2019
2
Transformation of Fonsecaea pedrosoi into sclerotic cells links to the refractoriness of experimental chromoblastomycosis in BALB/c mice via a mechanism involving a chitin-induced impairment of IFN-I^ production. ( 29481557 )
2018
3
From phaeohyphomycosis to disseminated chromoblastomycosis: A retrospective study of infections caused by dematiaceous fungi. ( 29656841 )
2018
4
Chromoblastomycosis due to Cladosporium langeronii. Molecular diagnosis of an agent previously diagnosed as Fonsecaea pedrosoi. ( 29924243 )
2018
5
Melanin: Quantification and protection against oxidative stress in chromoblastomycosis agents. ( 29669009 )
2018
6
Combination of Amphotericin B and Terbinafine against Melanized Fungi Associated with Chromoblastomycosis. ( 29581111 )
2018
7
Differential distribution patterns of Fonsecaea agents of chromoblastomycosis, exemplified by the first case due to F. monophora from Argentina. ( 29552459 )
2018
8
Case Report: Successful Treatment of Chromoblastomycosis Caused by <i>Fonsecaea monophora</i> in a Patient with Psoriasis Using Itraconazole and Acitretin. ( 29785921 )
2018
9
First case of chronic cutaneous chromoblastomycosis by Rhinocladiella similis aquired in Europe. ( 29885020 )
2018
10
Longitudinal melanonychia due to voriconazole therapy during treatment of chromoblastomycosis. ( 29030858 )
2018
11
Case Report: A Case of Chromoblastomycosis Caused by Fonsecaea pedrosoi in Vietnam. ( 29974323 )
2018
12
Molecular identification and antifungal susceptibility profiles of clinical strains of Fonsecaea spp. isolated from patients with chromoblastomycosis in Rio de Janeiro, Brazil. ( 30048450 )
2018
13
Uncommon presentation of chromoblastomycosis. ( 30063772 )
2018
14
Chromoblastomycosis: an etiological, epidemiological, clinical, diagnostic, and treatment update. ( 30066754 )
2018
15
Chromoblastomycosis: clinical experience and review of literature. ( 30113072 )
2018
16
An impressive case of chromoblastomycosis due to Fonsecaea pedrosoi in a patient with a long history of fungal infection. ( 30126716 )
2018
17
Chromoblastomycosis: an autochthonous case of a tropical disease. ( 30161267 )
2018
18
Identification of chromoblastomycosis agents by PCR based reverse line blot (PCR-RLB) hybridization assay. ( 30194974 )
2018
19
Chromoblastomycosis in immunosuppressed patients. ( 30257629 )
2018
20
In vitro susceptibility of chromoblastomycosis agents to antifungal drugs - a systematic review. ( 30266638 )
2018
21
Cutaneous chromoblastomycosis effectively treated with local heat monotherapy. ( 30280420 )
2018
22
A Model for Trans-Kingdom Pathogenicity in Fonsecaea Agents of Human Chromoblastomycosis. ( 30356683 )
2018
23
Chromoblastomycosis Caused by Fonsecaea nubica: First Report in Northern China and Literature Review. ( 30547378 )
2018
24
Squamous cell carcinoma arising from a chromomycosis lesion caused by Rhinocladiella aquaspersa with postsurgical recurrence of chromomycosis. ( 30310837 )
2018
25
Endobronchial Topical Amphotericin B Instillation for Pulmonary Chromomycosis After Lung Transplantation: A Case Report. ( 29661466 )
2018
26
Cutaneous chromomycosis caused by Arthrinium arundinis. ( 29682896 )
2018
27
Molecular identification of chromoblastomycosis clinical isolates in Guangdong. ( 28053146 )
2017
28
Correction: Molecular Epidemiology of Agents of Human Chromoblastomycosis in Brazil with the Description of Two Novel Species. ( 28122015 )
2017
29
Chromoblastomycosis of the leg. ( 29025254 )
2017
30
Study on the organization of cellular elements in the granulomatous lesion caused by chromoblastomycosis. ( 28753235 )
2017
31
Chromoblastomycosis. ( 27856522 )
2017
32
Mycetoma-like chromoblastomycosis: a diagnostic dilemma. ( 28233299 )
2017
33
Chromoblastomycosis in Taiwan: A report of 30 cases and a review of the literature. ( 29087525 )
2017
34
The Major Chromoblastomycosis Etiologic Agent<i>Fonsecaea pedrosoi</i>Activates the NLRP3 Inflammasome. ( 29209318 )
2017
35
Squamous cell carcinoma in long-standing chromoblastomycosis. ( 28272060 )
2017
36
Modulation of the immune response by Fonsecaea pedrosoi morphotypes in the course of experimental chromoblastomycosis and their role on inflammatory response chronicity. ( 28355277 )
2017
37
Successful treatment of chromoblastomycosis of 10-year duration due to Fonsecaea nubica. ( 29178398 )
2017
38
Molecular identification of chromoblastomycosis clinical isolates in Guangdong. ( 28992137 )
2017
39
Severe Chromoblastomycosis-Like Cutaneous Infection Caused by Chrysosporium keratinophilum. ( 28179902 )
2017
40
Image Gallery: Uncommon presentation of facial chromoblastomycosis caused by CladophialophoraA carrionii. ( 29313921 )
2017
41
Chromoblastomycosis and sporotrichosis, two endemic but neglected fungal infections in Madagascar. ( 28847419 )
2017
42
Chromoblastomycosis caused by Rhinocladiella similis: Case report. ( 28458993 )
2017
43
Comparative Genomics of Sibling Species of<i>Fonsecaea</i>Associated with Human Chromoblastomycosis. ( 29062304 )
2017
44
Dermoscopy of chromoblastomycosis. ( 29214105 )
2017
45
Chromoblastomycosis infection from a house plant. ( 29136064 )
2017
46
Chromoblastomycosis caused by Cladophialophora carrionii. ( 28540878 )
2017
47
Erratum: Molecular identification of chromoblastomycosis clinical isolates in Guangdong. ( 28541426 )
2017
48
Chromoblastomycosis: tissue modifications during itraconazole treatment. ( 28954095 )
2017
49
Chromoblastomycosis in India: Review of 169 cases. ( 28771470 )
2017
50
Chromoblastomycosis (Chromomycosis) ( 29261968 )
2017

Variations for Chromoblastomycosis

Expression for Chromoblastomycosis

Search GEO for disease gene expression data for Chromoblastomycosis.

Pathways for Chromoblastomycosis

GO Terms for Chromoblastomycosis

Biological processes related to Chromoblastomycosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.54 CCR1 CLEC7A CXCR3
2 extracellular matrix disassembly GO:0022617 9.32 MMP1 MMP9
3 T cell activation GO:0042110 9.26 CLEC7A IL4
4 immune response GO:0006955 9.26 CCR1 CXCR3 HLA-A IL4
5 collagen catabolic process GO:0030574 9.16 MMP1 MMP9
6 cytokine-mediated signaling pathway GO:0019221 8.92 CCR1 IL4 MMP1 MMP9

Molecular functions related to Chromoblastomycosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine binding GO:0019956 9.26 CCR1 CXCR3
2 C-C chemokine binding GO:0019957 9.16 CCR1 CXCR3
3 C-C chemokine receptor activity GO:0016493 8.96 CCR1 CXCR3
4 chemokine receptor activity GO:0004950 8.62 CCR1 CXCR3

Sources for Chromoblastomycosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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