MCID: CHR031
MIFTS: 44

Chromoblastomycosis

Categories: Infectious diseases, Rare diseases, Skin diseases

Aliases & Classifications for Chromoblastomycosis

MalaCards integrated aliases for Chromoblastomycosis:

Name: Chromoblastomycosis 12 53 59 44 15 17 72
Chromomycosis 12 75 53 59
Mossy Foot Disease 12 72

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:1562
ICD9CM 35 117.2
MeSH 44 D002862
SNOMED-CT 68 7255004
ICD10 33 B43.9
MESH via Orphanet 45 D002862
ICD10 via Orphanet 34 B43.0 B43.1 B43.2 more
UMLS via Orphanet 73 C0008582
Orphanet 59 ORPHA182
UMLS 72 C0008582 C3245522

Summaries for Chromoblastomycosis

NIH Rare Diseases : 53 Chromoblastomycosis is a chronic fungal infection characterized by raised and crusted lesions which affect the skin and subcutaneous tissue. It most often occurs on the limbs, but can affect any area of the body. Chromoblastomycosis is caused by several fungi found in soil, wood, and decaying plant material. It usually enters the skin through a minor injury such as a splinter. It is most common in areas with tropical and subtropical climates. Treatment of chromoblastomycosis may include medications like itraconazole and flucytosine, cryotherapy, or surgery.

MalaCards based summary : Chromoblastomycosis, also known as chromomycosis, is related to subcutaneous mycosis and corneal ulcer, and has symptoms including pruritus and symptoms. An important gene associated with Chromoblastomycosis is HLA-A (Major Histocompatibility Complex, Class I, A), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. Affiliated tissues include skin, brain and testes, and related phenotypes are hematopoietic system and homeostasis/metabolism

Disease Ontology : 12 A subcutaneous mycosis that is a chronic subcutaneous fungal infection, which presents as nodular or verrucoid, ulcerated, or crusted skin lesions on exposed areas of skin caused by Fonsecaea pedrosoi, Fonsecaea compacta, Cladophialophora carrionii or Phialophora verrucosa. Histological examination reveals muriform cells (with perpendicular septations) or thick walled, dark-colored, rounded forms (copper pennies) that are characteristic of this infection.

Wikipedia : 75 Chromoblastomycosis is a long-term fungal infection of the skin and subcutaneous tissue (a chronic... more...

Related Diseases for Chromoblastomycosis

Diseases related to Chromoblastomycosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 168)
# Related Disease Score Top Affiliating Genes
1 subcutaneous mycosis 30.7 CLEC7A CARD9
2 corneal ulcer 30.2 MMP9 CCR1
3 lichen planus 30.1 IL4 CXCR3
4 fungal keratitis 30.0 MMP9 CLEC7A
5 cryptococcosis 29.6 IL4 CARD9
6 pulmonary disease, chronic obstructive 29.5 MMP9 MMP1 CXCR3
7 aspergillosis 29.4 IL4 CLEC7A
8 opportunistic mycosis 29.1 IL4 CLEC7A CARD9
9 phaeohyphomycosis 10.5
10 mycetoma 10.4
11 sporotrichosis 10.4
12 hansen's disease 10.4
13 stevens-johnson syndrome/toxic epidermal necrolysis 10.4 HLA-A CXCR3
14 leprosy 3 10.3
15 squamous cell carcinoma 10.3
16 hematopoietic stem cell transplantation 10.3 HLA-A CLEC7A
17 aphthous stomatitis 10.3 IL4 HLA-A
18 spondyloarthropathy 10.3 IL4 HLA-A
19 oral lichen planus 10.3 MMP1 CXCR3
20 dermatitis 10.3
21 skin disease 10.3
22 transient hypogammaglobulinemia of infancy 10.3 IL4 CCR1
23 periodontosis 10.2 MMP9 HLA-A
24 orofacial granulomatosis 10.2 IL4 CXCR3
25 eumycotic mycetoma 10.2
26 lichen disease 10.2 IL4 CXCR3
27 spastic entropion 10.2 MMP9 MMP1
28 chronic actinic dermatitis 10.2 MMP9 MMP1
29 internal hemorrhoid 10.2 MMP9 MMP1
30 lobomycosis 10.2
31 light chain deposition disease 10.2 MMP9 MMP1
32 proliferative glomerulonephritis 10.2 IL4 CXCR3
33 adult astrocytic tumour 10.2 MMP9 MMP1
34 odontogenic myxoma 10.2 MMP9 MMP1
35 mitral valve disease 10.2 MMP1 IL4
36 collagenous colitis 10.2 MMP9 MMP1
37 pelvic organ prolapse 10.2 MMP9 MMP1
38 vulvovaginal candidiasis 10.2 IL4 CLEC7A
39 lepromatous leprosy 10.1
40 blastomycosis 10.1
41 histoplasmosis 10.1
42 pustulosis of palm and sole 10.1
43 psoriasis 10.1
44 lymphedema 10.1
45 chronic venous insufficiency 10.1 MMP9 MMP1
46 venous insufficiency 10.1 MMP9 MMP1
47 hypertensive heart disease 10.1 MMP9 MMP1
48 preterm premature rupture of the membranes 10.1 MMP9 MMP1
49 aortic aneurysm, familial abdominal, 1 10.1 MMP9 MMP1
50 scleritis 10.1 MMP9 IL4

Graphical network of the top 20 diseases related to Chromoblastomycosis:



Diseases related to Chromoblastomycosis

Symptoms & Phenotypes for Chromoblastomycosis

UMLS symptoms related to Chromoblastomycosis:


pruritus, symptoms

MGI Mouse Phenotypes related to Chromoblastomycosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.73 CARD9 CCR1 CLEC7A CXCR3 IL4 MMP9
2 homeostasis/metabolism MP:0005376 9.7 CARD9 CCR1 CLEC7A CXCR3 IL4 MMP1
3 immune system MP:0005387 9.5 CARD9 CCR1 CLEC7A CXCR3 IL4 MMP1
4 respiratory system MP:0005388 9.02 CCR1 CLEC7A CXCR3 IL4 MMP9

Drugs & Therapeutics for Chromoblastomycosis

DrugBank drugs 16 :

# Drug Name Indication DrugBank ID
1 Itraconazole For the treatment of the following fungal infections in immunocompromised and non-immunocompromised patients: pulmonary and extrapulmonary blastomycosis, histoplasmosis, aspergillosis, and onychomycosis. DB01167
2 Ketoconazole For the treatment of the following systemic fungal infections: candidiasis, chronic mucocutaneous candidiasis, oral thrush, candiduria, blastomycosis, coccidioidomycosis, histoplasmosis, chromomycosis, and paracoccidioidomycosis. DB01026

Search Clinical Trials , NIH Clinical Center for Chromoblastomycosis

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Flucytosine
Itraconazole
Ketoconazole

Cochrane evidence based reviews: chromoblastomycosis

Genetic Tests for Chromoblastomycosis

Anatomical Context for Chromoblastomycosis

MalaCards organs/tissues related to Chromoblastomycosis:

41
Skin, Brain, Testes, Kidney, Liver, Bone, Breast

Publications for Chromoblastomycosis

Articles related to Chromoblastomycosis:

(show top 50) (show all 1023)
# Title Authors PMID Year
1
Chromoblastomycosis with a sporotrichoid distribution. 38
31368452 2019
2
Microbiological contamination in donor corneas preserved for medium-term. 38
31240495 2019
3
New Molecular Markers Distinguishing Fonsecaea Agents of Chromoblastomycosis. 38
31317385 2019
4
Intracranial fungal granuloma: a single-institute study of 90 cases over 18 years. 38
31370017 2019
5
Successful treatment of chromoblastomycosis using ALA-PDT in a patient with leukopenia. 38
30769166 2019
6
Endemic Mycoses in Children. 38
31205246 2019
7
Elbow Malformation with Osteoarthritis and Bone Destruction Caused by Chromoblastomycosis. 38
30955128 2019
8
Cutaneous chromoblastomycosis effectively treated with local heat monotherapy. 38
30280420 2019
9
Case report: Fever- pneumonia- lymphadenectasis- osteolytic- subcutaneous nodule: Disseminated chromoblastomycosis caused by phialophora. 38
31229375 2019
10
[Long-pulsed 1064 nm Nd: YAG laser combined with terbinafine against chromoblastomycosis caused by Fonsecaea nubica and the effect of laser therapy in a Wistar rat model]. 38
31270051 2019
11
Synergistic effect of terbinafine and amphotericin B in killing Fonsecaea nubica in vitro and in vivo. 38
31241660 2019
12
Dermoscopic features in nodular chromoblastomycosis. 38
30565211 2019
13
Lymphocutaneous Sporotrichosis of Face with Verrucous Lesions: A Case Report. 38
31149578 2019
14
Mixed secondary bacterial infection is associated with severe lesions of chromoblastomycosis in a neglected population from Brazil. 38
31262546 2019
15
Next-generation sequencing for hypothesis-free genomic detection of invasive tropical infections in poly-microbially contaminated, formalin-fixed, paraffin-embedded tissue samples - a proof-of-principle assessment. 38
30961537 2019
16
Diagnostic value of fluorescein-labeled chitinase staining in formalin-fixed and paraffin-embedded tissues of fungal disease. 38
31329921 2019
17
A Case of Chromoblastomycosis Caused by Fonsecaea Pedrosoi and Investigation of the Pathogenic Fungi. 38
30701405 2019
18
Chromoblastomycosis in the Amazon region, Brazil, caused by Fonsecaea pedrosoi, Fonsecaea nubica, and Rhinocladiella similis: Clinicopathology, susceptibility, and molecular identification. 38
31329924 2019
19
Transcriptional profiling of macrophages infected with Fonsecaea monophora. 38
30656755 2019
20
In vitro susceptibility of chromoblastomycosis agents to antifungal drugs: A systematic review. 38
30266638 2019
21
Exophiala dermatitidis: Key issues of an opportunistic fungal pathogen. 38
30887863 2019
22
Exophiala psychrophila: A new agent of chromoblastomycosis. 38
30533349 2019
23
Chromoblastomycosis: an autochthonous case of a tropical disease. 38
30161267 2019
24
Melanin: Quantification and protection against oxidative stress in chromoblastomycosis agents. 38
29669009 2019
25
Chromoblastomycosis Caused by Fonsecaea nubica: First Report in Northern China and Literature Review. 38
30547378 2019
26
Case Report: A Case of Chromoblastomycosis Caused by Fonsecaea pedrosoi in Vietnam. 38
29974323 2019
27
Increased virulence of albino mutant of Fonsecaea monophora in Galleria mellonella. 38
30759240 2019
28
Cutaneous Chromoblastomycosis: A Prototypal Case. 38
30789034 2019
29
[Chromoblastomycosis in Mexico. A forgotten disease]. 38
30753765 2019
30
Study of tissue inflammatory response in different mice strains infected by dematiaceous fungi Fonsecaea pedrosoi. 38
30726460 2019
31
First case of chronic cutaneous chromoblastomycosis by Rhinocladiella similis aquired in Europe. 38
29885020 2018
32
Identification of chromoblastomycosis agents by PCR based reverse line blot (PCR-RLB) hybridization assay. 38
30194974 2018
33
An impressive case of chromoblastomycosis due to Fonsecaea pedrosoi in a patient with a long history of fungal infection. 38
30126716 2018
34
Chromoblastomycosis Caused by Phialophora verrucosa in a Costa Rican Child with Skin Sequelae due to Snake Bite. 38
30656078 2018
35
Melanization of a meristematic mutant of Fonsecaea monophora increase the pathogenesis in a BALB/c mice infection model. 38
29444317 2018
36
Chromoblastomycosis: clinical experience and review of literature. 38
30113072 2018
37
Epidemiology of Subcutaneous Mycoses in Northeast India: A Retrospective Study. 38
30504979 2018
38
Squamous cell carcinoma arising from a chromomycosis lesion caused by Rhinocladiella aquaspersa with postsurgical recurrence of chromomycosis. 38
30310837 2018
39
Chromoblastomycosis in immunosuppressed patients. 38
30257629 2018
40
Exophiala dermatitidis isolates from various sources: using alternative invertebrate host organisms (Caenorhabditis elegans and Galleria mellonella) to determine virulence. 38
30143674 2018
41
[Extensive cutaneous chromomycosis: Efficacy of combined terbinafine and cryotherapy]. 38
29779858 2018
42
Case Report: Successful Treatment of Chromoblastomycosis Caused by Fonsecaea monophora in a Patient with Psoriasis Using Itraconazole and Acitretin. 38
29785921 2018
43
Galleria mellonella as a model invertebrate host for the study of muriform cells of dematiaceous fungi. 38
29927339 2018
44
Molecular identification and antifungal susceptibility profiles of clinical strains of Fonsecaea spp. isolated from patients with chromoblastomycosis in Rio de Janeiro, Brazil. 38
30048450 2018
45
Chromoblastomycosis: an etiological, epidemiological, clinical, diagnostic, and treatment update. 38
30066754 2018
46
Combination of Amphotericin B and Terbinafine against Melanized Fungi Associated with Chromoblastomycosis. 38
29581111 2018
47
Chromoblastomycosis in Taiwan: A report of 30 cases and a review of the literature. 38
29087525 2018
48
Melanin particles isolated from the fungus Fonsecaea pedrosoi activates the human complement system. 38
29947713 2018
49
Uncommon presentation of chromoblastomycosis. 38
30063772 2018
50
From phaeohyphomycosis to disseminated chromoblastomycosis: A retrospective study of infections caused by dematiaceous fungi. 38
29656841 2018

Variations for Chromoblastomycosis

Expression for Chromoblastomycosis

Search GEO for disease gene expression data for Chromoblastomycosis.

Pathways for Chromoblastomycosis

GO Terms for Chromoblastomycosis

Biological processes related to Chromoblastomycosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.54 CXCR3 CLEC7A CCR1
2 extracellular matrix disassembly GO:0022617 9.32 MMP9 MMP1
3 T cell activation GO:0042110 9.26 IL4 CLEC7A
4 immune response GO:0006955 9.26 IL4 HLA-A CXCR3 CCR1
5 collagen catabolic process GO:0030574 9.16 MMP9 MMP1
6 cytokine-mediated signaling pathway GO:0019221 8.92 MMP9 MMP1 IL4 CCR1

Molecular functions related to Chromoblastomycosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine binding GO:0019956 9.26 CXCR3 CCR1
2 C-C chemokine binding GO:0019957 9.16 CXCR3 CCR1
3 C-C chemokine receptor activity GO:0016493 8.96 CXCR3 CCR1
4 chemokine receptor activity GO:0004950 8.62 CXCR3 CCR1

Sources for Chromoblastomycosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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