MCID: CHR031
MIFTS: 44

Chromoblastomycosis

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Chromoblastomycosis

MalaCards integrated aliases for Chromoblastomycosis:

Name: Chromoblastomycosis 12 53 59 44 15 73
Chromomycosis 12 76 53 59
Mossy Foot Disease 12 73

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:1562
ICD10 33 B43.9
ICD9CM 35 117.2
MeSH 44 D002862
Orphanet 59 ORPHA182
MESH via Orphanet 45 D002862
ICD10 via Orphanet 34 B43.1 B43.0 B43.2 more
UMLS via Orphanet 74 C0008582

Summaries for Chromoblastomycosis

NIH Rare Diseases : 53 Chromoblastomycosis is a chronic fungal infection characterized by raised and crusted lesions which affect the skin and subcutaneous tissue. It most often occurs on the limbs, but can affect any area of the body. Chromoblastomycosis is caused by several fungi found in soil, wood, and decaying plant material. It usually enters the skin through a minor injury such as a splinter. It is most common in areas with tropical and subtropical climates. Treatment of chromoblastomycosis may include medications like itraconazole and flucytosine, cryotherapy, or surgery. 

MalaCards based summary : Chromoblastomycosis, also known as chromomycosis, is related to pulmonary disease, chronic obstructive and hematopoietic stem cell transplantation, and has symptoms including pruritus and symptoms. An important gene associated with Chromoblastomycosis is HLA-A (Major Histocompatibility Complex, Class I, A), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. Affiliated tissues include skin, brain and testes, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Disease Ontology : 12 A subcutaneous mycosis that is a chronic subcutaneous fungal infection, which presents as nodular or verrucoid, ulcerated, or crusted skin lesions on exposed areas of skin caused by Fonsecaea pedrosoi, Fonsecaea compacta, Cladophialophora carrionii or Phialophora verrucosa. Histological examination reveals muriform cells (with perpendicular septations) or thick walled, dark-colored, rounded forms (copper pennies) that are characteristic of this infection.

Wikipedia : 76 Chromoblastomycosis (also known as chromomycosis, cladosporiosis, Fonseca\'s disease, Pedroso\'s... more...

Related Diseases for Chromoblastomycosis

Diseases related to Chromoblastomycosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 100)
# Related Disease Score Top Affiliating Genes
1 pulmonary disease, chronic obstructive 29.1 CXCR3 MMP1 MMP9
2 hematopoietic stem cell transplantation 10.4 CLEC7A HLA-A
3 aphthous stomatitis 10.4 HLA-A IL4
4 rheumatic heart disease 10.4 HLA-A IL4
5 oral lichen planus 10.3 CXCR3 MMP1
6 periodontosis 10.3 HLA-A MMP9
7 spondyloarthropathy 10.3 HLA-A IL4
8 orofacial granulomatosis 10.3 CXCR3 IL4
9 spastic entropion 10.3 MMP1 MMP9
10 chronic actinic dermatitis 10.3 MMP1 MMP9
11 corneal ulcer 10.3 CCR1 MMP9
12 lichen disease 10.3 CXCR3 IL4
13 internal hemorrhoid 10.3 MMP1 MMP9
14 proliferative glomerulonephritis 10.3 CXCR3 IL4
15 light chain deposition disease 10.2 MMP1 MMP9
16 adult astrocytic tumour 10.2 MMP1 MMP9
17 mitral valve disease 10.2 IL4 MMP1
18 adenomyosis 10.2 MMP1 MMP9
19 rubella 10.2 HLA-A IL4
20 odontogenic myxoma 10.2 MMP1 MMP9
21 vulvovaginal candidiasis 10.2 CLEC7A IL4
22 interstitial cystitis 10.2 CXCR3 IL4
23 chronic venous insufficiency 10.2 MMP1 MMP9
24 pelvic organ prolapse 10.2 MMP1 MMP9
25 venous insufficiency 10.2 MMP1 MMP9
26 hypertensive heart disease 10.2 MMP1 MMP9
27 aortic aneurysm, familial thoracic 1 10.1 MMP1 MMP9
28 scleritis 10.1 IL4 MMP9
29 angiostrongyliasis 10.1 IL4 MMP9
30 allergic contact dermatitis 10.1 CXCR3 IL4
31 cerebritis 10.1
32 blepharitis 10.1 IL4 MMP9
33 pulmonary emphysema 10.1 MMP1 MMP9
34 eosinophilic meningitis 10.1 IL4 MMP9
35 carotid artery disease 10.1 MMP1 MMP9
36 sporotrichosis 10.1
37 tropical spastic paraparesis 10.1 CXCR3 MMP9
38 carotid stenosis 10.0 MMP1 MMP9
39 phaeohyphomycosis 10.0
40 squamous cell carcinoma 10.0
41 bronchiolitis obliterans 10.0 CXCR3 MMP9
42 mycetoma 10.0
43 bare lymphocyte syndrome, type ii 10.0 CARD9 HLA-A
44 varicose veins 10.0 MMP1 MMP9
45 contact dermatitis 9.9 CXCR3 IL4
46 aspergillosis 9.9 CLEC7A IL4
47 inguinal hernia 9.9 MMP1 MMP9
48 subcutaneous mycosis 9.9 CARD9 CLEC7A
49 coccidioidomycosis 9.9 CARD9 CLEC7A
50 takayasu arteritis 9.9 HLA-A MMP9

Graphical network of the top 20 diseases related to Chromoblastomycosis:



Diseases related to Chromoblastomycosis

Symptoms & Phenotypes for Chromoblastomycosis

UMLS symptoms related to Chromoblastomycosis:


pruritus, symptoms

GenomeRNAi Phenotypes related to Chromoblastomycosis according to GeneCards Suite gene sharing:

26 (show all 39)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-101 10.14 CLEC7A CCR1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-103 10.14 CLEC7A HLA-A
3 Increased shRNA abundance (Z-score > 2) GR00366-A-105 10.14 CCR1 CXCR3
4 Increased shRNA abundance (Z-score > 2) GR00366-A-107 10.14 CLEC7A
5 Increased shRNA abundance (Z-score > 2) GR00366-A-110 10.14 HLA-A
6 Increased shRNA abundance (Z-score > 2) GR00366-A-113 10.14 CCR1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-118 10.14 HLA-A
8 Increased shRNA abundance (Z-score > 2) GR00366-A-12 10.14 CLEC7A
9 Increased shRNA abundance (Z-score > 2) GR00366-A-120 10.14 CCR1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-128 10.14 CLEC7A
11 Increased shRNA abundance (Z-score > 2) GR00366-A-135 10.14 CLEC7A
12 Increased shRNA abundance (Z-score > 2) GR00366-A-143 10.14 CLEC7A
13 Increased shRNA abundance (Z-score > 2) GR00366-A-147 10.14 CCR1 CLEC7A CXCR3
14 Increased shRNA abundance (Z-score > 2) GR00366-A-149 10.14 CLEC7A
15 Increased shRNA abundance (Z-score > 2) GR00366-A-156 10.14 HLA-A
16 Increased shRNA abundance (Z-score > 2) GR00366-A-158 10.14 CLEC7A
17 Increased shRNA abundance (Z-score > 2) GR00366-A-164 10.14 CLEC7A
18 Increased shRNA abundance (Z-score > 2) GR00366-A-178 10.14 HLA-A
19 Increased shRNA abundance (Z-score > 2) GR00366-A-186 10.14 CLEC7A
20 Increased shRNA abundance (Z-score > 2) GR00366-A-19 10.14 HLA-A
21 Increased shRNA abundance (Z-score > 2) GR00366-A-192 10.14 CXCR3
22 Increased shRNA abundance (Z-score > 2) GR00366-A-195 10.14 CCR1
23 Increased shRNA abundance (Z-score > 2) GR00366-A-196 10.14 CCR1
24 Increased shRNA abundance (Z-score > 2) GR00366-A-202 10.14 CLEC7A
25 Increased shRNA abundance (Z-score > 2) GR00366-A-205 10.14 CLEC7A
26 Increased shRNA abundance (Z-score > 2) GR00366-A-214 10.14 CLEC7A
27 Increased shRNA abundance (Z-score > 2) GR00366-A-23 10.14 CXCR3
28 Increased shRNA abundance (Z-score > 2) GR00366-A-29 10.14 CLEC7A
29 Increased shRNA abundance (Z-score > 2) GR00366-A-30 10.14 CLEC7A
30 Increased shRNA abundance (Z-score > 2) GR00366-A-31 10.14 HLA-A
31 Increased shRNA abundance (Z-score > 2) GR00366-A-36 10.14 CCR1
32 Increased shRNA abundance (Z-score > 2) GR00366-A-57 10.14 CLEC7A
33 Increased shRNA abundance (Z-score > 2) GR00366-A-63 10.14 CCR1
34 Increased shRNA abundance (Z-score > 2) GR00366-A-7 10.14 HLA-A
35 Increased shRNA abundance (Z-score > 2) GR00366-A-74 10.14 HLA-A
36 Increased shRNA abundance (Z-score > 2) GR00366-A-79 10.14 CLEC7A
37 Increased shRNA abundance (Z-score > 2) GR00366-A-81 10.14 CXCR3
38 Increased shRNA abundance (Z-score > 2) GR00366-A-82 10.14 CCR1
39 Increased shRNA abundance (Z-score > 2) GR00366-A-9 10.14 CLEC7A CXCR3

MGI Mouse Phenotypes related to Chromoblastomycosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.73 CARD9 CCR1 CLEC7A CXCR3 IL4 MMP9
2 homeostasis/metabolism MP:0005376 9.7 CARD9 CCR1 CLEC7A CXCR3 IL4 MMP1
3 immune system MP:0005387 9.5 CARD9 CCR1 CLEC7A CXCR3 IL4 MMP1
4 respiratory system MP:0005388 9.02 CCR1 CLEC7A CXCR3 IL4 MMP9

Drugs & Therapeutics for Chromoblastomycosis

Search Clinical Trials , NIH Clinical Center for Chromoblastomycosis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: chromoblastomycosis

Genetic Tests for Chromoblastomycosis

Anatomical Context for Chromoblastomycosis

MalaCards organs/tissues related to Chromoblastomycosis:

41
Skin, Brain, Testes, T Cells, Medulla Oblongata, Monocytes, Breast

Publications for Chromoblastomycosis

Articles related to Chromoblastomycosis:

(show top 50) (show all 422)
# Title Authors Year
1
Transformation of Fonsecaea pedrosoi into sclerotic cells links to the refractoriness of experimental chromoblastomycosis in BALB/c mice via a mechanism involving a chitin-induced impairment of IFN-I^ production. ( 29481557 )
2018
2
From phaeohyphomycosis to disseminated chromoblastomycosis: A retrospective study of infections caused by dematiaceous fungi. ( 29656841 )
2018
3
Chromoblastomycosis due to Cladosporium langeronii. Molecular diagnosis of an agent previously diagnosed as Fonsecaea pedrosoi. ( 29924243 )
2018
4
Melanin: Quantification and protection against oxidative stress in chromoblastomycosis agents. ( 29669009 )
2018
5
Combination of Amphotericin B and Terbinafine against Melanized Fungi Associated with Chromoblastomycosis. ( 29581111 )
2018
6
Differential distribution patterns of Fonsecaea agents of chromoblastomycosis, exemplified by the first case due to F. monophora from Argentina. ( 29552459 )
2018
7
Case Report: Successful Treatment of Chromoblastomycosis Caused by <i>Fonsecaea monophora</i> in a Patient with Psoriasis Using Itraconazole and Acitretin. ( 29785921 )
2018
8
First case of chronic cutaneous chromoblastomycosis by Rhinocladiella similis aquired in Europe. ( 29885020 )
2018
9
Longitudinal melanonychia due to voriconazole therapy during treatment of chromoblastomycosis. ( 29030858 )
2018
10
Case Report: A Case of Chromoblastomycosis Caused by Fonsecaea pedrosoi in Vietnam. ( 29974323 )
2018
11
Molecular identification of chromoblastomycosis clinical isolates in Guangdong. ( 28053146 )
2017
12
Correction: Molecular Epidemiology of Agents of Human Chromoblastomycosis in Brazil with the Description of Two Novel Species. ( 28122015 )
2017
13
Chromoblastomycosis of the leg. ( 29025254 )
2017
14
Study on the organization of cellular elements in the granulomatous lesion caused by chromoblastomycosis. ( 28753235 )
2017
15
Chromoblastomycosis. ( 27856522 )
2017
16
Mycetoma-like chromoblastomycosis: a diagnostic dilemma. ( 28233299 )
2017
17
Chromoblastomycosis in Taiwan: A report of 30 cases and a review of the literature. ( 29087525 )
2017
18
The Major Chromoblastomycosis Etiologic Agent<i>Fonsecaea pedrosoi</i>Activates the NLRP3 Inflammasome. ( 29209318 )
2017
19
Squamous cell carcinoma in long-standing chromoblastomycosis. ( 28272060 )
2017
20
Modulation of the immune response by Fonsecaea pedrosoi morphotypes in the course of experimental chromoblastomycosis and their role on inflammatory response chronicity. ( 28355277 )
2017
21
Successful treatment of chromoblastomycosis of 10-year duration due to Fonsecaea nubica. ( 29178398 )
2017
22
Molecular identification of chromoblastomycosis clinical isolates in Guangdong. ( 28992137 )
2017
23
Severe Chromoblastomycosis-Like Cutaneous Infection Caused by Chrysosporium keratinophilum. ( 28179902 )
2017
24
Image Gallery: Uncommon presentation of facial chromoblastomycosis caused by CladophialophoraA carrionii. ( 29313921 )
2017
25
Chromoblastomycosis and sporotrichosis, two endemic but neglected fungal infections in Madagascar. ( 28847419 )
2017
26
Chromoblastomycosis caused by Rhinocladiella similis: Case report. ( 28458993 )
2017
27
Comparative Genomics of Sibling Species of<i>Fonsecaea</i>Associated with Human Chromoblastomycosis. ( 29062304 )
2017
28
Dermoscopy of chromoblastomycosis. ( 29214105 )
2017
29
Chromoblastomycosis infection from a house plant. ( 29136064 )
2017
30
Chromoblastomycosis caused by Cladophialophora carrionii. ( 28540878 )
2017
31
Erratum: Molecular identification of chromoblastomycosis clinical isolates in Guangdong. ( 28541426 )
2017
32
Chromoblastomycosis: tissue modifications during itraconazole treatment. ( 28954095 )
2017
33
Chromoblastomycosis in India: Review of 169 cases. ( 28771470 )
2017
34
Chromoblastomycosis (Chromomycosis) ( 29261968 )
2017
35
Counterfeit Pennies: Distinguishing Chromoblastomycosis From Phaeohyphomycotic Infections. ( 28525909 )
2017
36
Cytodiagnostic copper pennies in chromoblastomycosis. ( 27057510 )
2016
37
Immune response in human chromoblastomycosis and eumycetoma - focusing on human interleukin-17A, interferon-gamma, tumour necrosis factor-alpha, interleukin-1 beta and human beta-defensin-2. ( 27402133 )
2016
38
First case of chromoblastomycosis due to Phoma insulana. ( 27726899 )
2016
39
Two cases of axillary chromoblastomycosis. ( 27279319 )
2016
40
Molecular Epidemiology of Agents of Human Chromoblastomycosis in Brazil with the Description of Two Novel Species. ( 27893750 )
2016
41
Draft Genome Sequence of Fonsecaea monophora Strain CBS 269.37, an Agent of Human Chromoblastomycosis. ( 27469960 )
2016
42
A case of chromoblastomycosis by Fonsecaea nubica indicating a possible insect route of transmission. ( 27330038 )
2016
43
Unusual Presentation of Cutaneous Chromoblastomycosis. ( 27149336 )
2016
44
Chromoblastomycosis caused by Cladophialophora carrionii in a skin graft recipient. ( 27843190 )
2016
45
Chromoblastomycosis due to Fonsecaea monophora misdiagnosed as sporotrichosis and cutaneous tuberculosis in a pulmonary tuberculosis patient. ( 27330937 )
2016
46
Response of chromoblastomycosis to voriconazole. ( 27828652 )
2016
47
Corrigendum to &amp;quot;First case of chromoblastomycosis from Bangladesh&amp;quot; [Med. Mycol. Case Rep. 10 (2015) 1-3]. ( 27330936 )
2016
48
Draft Genome Sequence of Fonsecaea nubica Strain CBS 269.64, Causative Agent of Human Chromoblastomycosis. ( 27491988 )
2016
49
Chromoblastomycosis Associated with Bone and Central Nervous Involvement System in an Immunocompetent Child Caused by Exophiala Spinifera. ( 27293256 )
2016
50
The Effectiveness of a Multifocal Training to Improve the Treatment of Chromoblastomycosis in Rural Madagascar. ( 27524747 )
2016

Variations for Chromoblastomycosis

Expression for Chromoblastomycosis

Search GEO for disease gene expression data for Chromoblastomycosis.

Pathways for Chromoblastomycosis

GO Terms for Chromoblastomycosis

Biological processes related to Chromoblastomycosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 collagen catabolic process GO:0030574 9.16 MMP1 MMP9
2 T cell activation GO:0042110 8.96 CLEC7A IL4
3 cytokine-mediated signaling pathway GO:0019221 8.92 CCR1 IL4 MMP1 MMP9

Molecular functions related to Chromoblastomycosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine receptor activity GO:0004950 8.62 CCR1 CXCR3

Sources for Chromoblastomycosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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