MCID: CHR031
MIFTS: 44

Chromoblastomycosis

Categories: Infectious diseases, Rare diseases, Skin diseases

Aliases & Classifications for Chromoblastomycosis

MalaCards integrated aliases for Chromoblastomycosis:

Name: Chromoblastomycosis 12 52 58 43 15 17 71
Chromomycosis 12 74 52 58
Mossy Foot Disease 12 71

Classifications:

Orphanet: 58  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:1562
ICD9CM 34 117.2
MeSH 43 D002862
SNOMED-CT 67 7255004
ICD10 32 B43.9
MESH via Orphanet 44 D002862
ICD10 via Orphanet 33 B43.0 B43.1 B43.2 more
UMLS via Orphanet 72 C0008582
Orphanet 58 ORPHA182
UMLS 71 C0008582 C3245522

Summaries for Chromoblastomycosis

NIH Rare Diseases : 52 Chromoblastomycosis is a chronic fungal infection characterized by raised and crusted lesions which affect the skin and subcutaneous tissue . It most often occurs on the limbs, but can affect any area of the body. Chromoblastomycosis is caused by several fungi found in soil, wood, and decaying plant material. It usually enters the skin through a minor injury such as a splinter. It is most common in areas with tropical and subtropical climates. Treatment of chromoblastomycosis may include medications like itraconazole and flucytosine , cryotherapy , or surgery.

MalaCards based summary : Chromoblastomycosis, also known as chromomycosis, is related to histoplasmosis and sporotrichosis, and has symptoms including pruritus and symptoms. An important gene associated with Chromoblastomycosis is IL4 (Interleukin 4), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. Affiliated tissues include skin, bone and brain, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Disease Ontology : 12 A subcutaneous mycosis that is a chronic subcutaneous fungal infection, which presents as nodular or verrucoid, ulcerated, or crusted skin lesions on exposed areas of skin caused by Fonsecaea pedrosoi, Fonsecaea compacta, Cladophialophora carrionii or Phialophora verrucosa. Histological examination reveals muriform cells (with perpendicular septations) or thick walled, dark-colored, rounded forms (copper pennies) that are characteristic of this infection.

Wikipedia : 74 Chromoblastomycosis is a long-term fungal infection of the skin and subcutaneous tissue (a chronic... more...

Related Diseases for Chromoblastomycosis

Diseases related to Chromoblastomycosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 194)
# Related Disease Score Top Affiliating Genes
1 histoplasmosis 30.2 HLA-A CLEC7A CCR6
2 sporotrichosis 30.2 CLEC7A CBSL CARD9
3 uveitis 30.1 IL4 HLA-A CXCR3
4 candidiasis 30.0 IL4 CLEC7A CARD9
5 fungal keratitis 30.0 MMP9 CLEC7A CLEC4E
6 meningitis 30.0 MMP9 IL4 CCL3
7 pyoderma 30.0 MMP9 MMP1 CCR6
8 mucormycosis 29.8 CLEC7A CCR6 CARD9
9 sarcoidosis 1 29.7 HLA-A CXCR3 CCR6 CCL3
10 tuberculoid leprosy 29.6 IL4 CCR6
11 aspergillosis 29.6 IL4 CLEC7A CCR6 CCL3
12 corneal ulcer 29.4 MMP9 MMP1 CLEC7A CLEC6A CCR1
13 pityriasis versicolor 29.2 CLEC7A CLEC6A CLEC4E CBSL
14 phaeohyphomycosis 29.2 CLEC7A CLEC6A CLEC4E CLEC4D CBSL CARD9
15 tinea corporis 29.2 CLEC6A CLEC4E CBSL CARD9
16 pulmonary disease, chronic obstructive 29.1 MMP9 MMP1 IL4 CXCR3 CCR6 CCL3
17 cryptococcosis 29.1 IL4 CLEC7A CLEC6A CLEC4D CCR6
18 blastomycosis 28.8 CLEC7A CLEC6A CLEC4E CLEC4D CCR6 CARD9
19 opportunistic mycosis 28.6 IL4 CLEC7A CLEC6A CLEC4E CCR6 CARD9
20 rheumatoid arthritis 28.2 SYK MMP9 MMP1 IL4 CXCR3 CCR6
21 systemic lupus erythematosus 28.2 SYK MMP9 IL4 HLA-A CXCR3 CCR6
22 dermatophytosis 28.0 CLEC7A CLEC6A CLEC4E CLEC4D CCR6 CBSL
23 subcutaneous mycosis 27.2 SYK DCLK3 CLEC7A CLEC6A CLEC4E CLEC4D
24 chronic actinic dermatitis 10.4 MMP9 MMP1
25 mycetoma 10.4
26 spastic entropion 10.4 MMP9 MMP1
27 hansen's disease 10.4
28 light chain deposition disease 10.4 MMP9 MMP1
29 loiasis 10.4 IL4 CCL3
30 odontogenic myxoma 10.3 MMP9 MMP1
31 leprosy 3 10.3
32 squamous cell carcinoma 10.3
33 orofacial granulomatosis 10.3 IL4 CXCR3 CCL3
34 cytomegalovirus infection 10.3 HLA-A CCR1 CCL3
35 stevens-johnson syndrome/toxic epidermal necrolysis 10.3 HLA-A CXCR3
36 periapical granuloma 10.3 IL4 CXCR3 CCL3
37 dermatitis 10.3
38 skin disease 10.3
39 tuberculous meningitis 10.2 MMP9 CCL3
40 aggressive periodontitis 10.2 MMP9 MMP1 IL4
41 periodontitis 10.2 MMP9 MMP1 IL4
42 common wart 10.2 CLEC6A CLEC4E
43 angiostrongyliasis 10.2 MMP9 IL4
44 chorioamnionitis 10.2 MMP9 MMP1 IL4
45 gingivitis 10.2 MMP9 MMP1 IL4
46 eumycotic mycetoma 10.2
47 neuritis 10.2 MMP9 IL4 CCL3
48 proteasome-associated autoinflammatory syndrome 1 10.2 MMP9 IL4 CCL3
49 lobomycosis 10.2
50 secondary progressive multiple sclerosis 10.2 MMP9 IL4 CXCR3

Graphical network of the top 20 diseases related to Chromoblastomycosis:



Diseases related to Chromoblastomycosis

Symptoms & Phenotypes for Chromoblastomycosis

UMLS symptoms related to Chromoblastomycosis:


pruritus, symptoms

GenomeRNAi Phenotypes related to Chromoblastomycosis according to GeneCards Suite gene sharing:

26 (show all 40)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-101 9.97 CLEC7A
2 Increased shRNA abundance (Z-score > 2) GR00366-A-103 9.97 CLEC4D CLEC7A HLA-A
3 Increased shRNA abundance (Z-score > 2) GR00366-A-107 9.97 CLEC4D CLEC7A
4 Increased shRNA abundance (Z-score > 2) GR00366-A-108 9.97 CLEC4D
5 Increased shRNA abundance (Z-score > 2) GR00366-A-110 9.97 HLA-A
6 Increased shRNA abundance (Z-score > 2) GR00366-A-118 9.97 HLA-A
7 Increased shRNA abundance (Z-score > 2) GR00366-A-12 9.97 CLEC7A
8 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.97 CLEC4D
9 Increased shRNA abundance (Z-score > 2) GR00366-A-128 9.97 CLEC7A
10 Increased shRNA abundance (Z-score > 2) GR00366-A-135 9.97 CLEC7A
11 Increased shRNA abundance (Z-score > 2) GR00366-A-137 9.97 CLEC4D
12 Increased shRNA abundance (Z-score > 2) GR00366-A-143 9.97 CLEC7A
13 Increased shRNA abundance (Z-score > 2) GR00366-A-144 9.97 CLEC7A
14 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.97 CLEC7A
15 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.97 CLEC7A
16 Increased shRNA abundance (Z-score > 2) GR00366-A-151 9.97 CLEC4D
17 Increased shRNA abundance (Z-score > 2) GR00366-A-158 9.97 CLEC7A
18 Increased shRNA abundance (Z-score > 2) GR00366-A-163 9.97 CLEC4D
19 Increased shRNA abundance (Z-score > 2) GR00366-A-164 9.97 CLEC7A
20 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.97 CLEC4D
21 Increased shRNA abundance (Z-score > 2) GR00366-A-178 9.97 HLA-A
22 Increased shRNA abundance (Z-score > 2) GR00366-A-186 9.97 CLEC7A
23 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.97 HLA-A
24 Increased shRNA abundance (Z-score > 2) GR00366-A-194 9.97 CLEC4D
25 Increased shRNA abundance (Z-score > 2) GR00366-A-202 9.97 CLEC7A
26 Increased shRNA abundance (Z-score > 2) GR00366-A-205 9.97 CLEC7A
27 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.97 CLEC7A
28 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.97 CLEC4D CLEC7A
29 Increased shRNA abundance (Z-score > 2) GR00366-A-30 9.97 CLEC7A
30 Increased shRNA abundance (Z-score > 2) GR00366-A-31 9.97 HLA-A
31 Increased shRNA abundance (Z-score > 2) GR00366-A-46 9.97 CLEC4D
32 Increased shRNA abundance (Z-score > 2) GR00366-A-47 9.97 CLEC4D
33 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.97 CLEC4D
34 Increased shRNA abundance (Z-score > 2) GR00366-A-57 9.97 CLEC7A
35 Increased shRNA abundance (Z-score > 2) GR00366-A-7 9.97 HLA-A
36 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.97 HLA-A
37 Increased shRNA abundance (Z-score > 2) GR00366-A-77 9.97 CLEC4D
38 Increased shRNA abundance (Z-score > 2) GR00366-A-9 9.97 CLEC7A
39 Increased shRNA abundance (Z-score > 2) GR00366-A-96 9.97 CLEC4D
40 Increased shRNA abundance (Z-score > 2) GR00366-A-99 9.97 CLEC4D

MGI Mouse Phenotypes related to Chromoblastomycosis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.1 CARD9 CBSL CCR1 CCR6 CLEC4D CLEC4E
2 homeostasis/metabolism MP:0005376 10.03 CARD9 CBSL CCR1 CCR6 CLEC4D CLEC4E
3 immune system MP:0005387 9.97 CARD9 CBSL CCR1 CCR6 CLEC4D CLEC4E
4 renal/urinary system MP:0005367 9.5 CBSL CCR1 CLEC6A CXCR3 IL4 MMP9
5 respiratory system MP:0005388 9.23 CBSL CCR1 CLEC4D CLEC7A CXCR3 IL4

Drugs & Therapeutics for Chromoblastomycosis

Search Clinical Trials , NIH Clinical Center for Chromoblastomycosis

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Flucytosine

Cochrane evidence based reviews: chromoblastomycosis

Genetic Tests for Chromoblastomycosis

Anatomical Context for Chromoblastomycosis

MalaCards organs/tissues related to Chromoblastomycosis:

40
Skin, Bone, Brain, Testes, Kidney, Liver, Breast

Publications for Chromoblastomycosis

Articles related to Chromoblastomycosis:

(show top 50) (show all 1035)
# Title Authors PMID Year
1
Aspartic peptidase of Phialophora verrucosa as target of HIV peptidase inhibitors: blockage of its enzymatic activity and interference with fungal growth and macrophage interaction. 61
32037904 2020
2
Chromoblastomycosis in the Amazon region, Brazil, caused by Fonsecaea pedrosoi, Fonsecaea nubica, and Rhinocladiella similis: Clinicopathology, susceptibility, and molecular identification. 61
31329924 2020
3
Fonsecaea pedrosoi Conidia Induces Activation of Dendritic Cells and Increases CD11c+ Cells in Regional Lymph Nodes During Experimental Chromoblastomycosis. 61
32008205 2020
4
An optimized Agrobacterium tumefaciens-mediated transformation system for random insertional mutagenesis in Fonsecaea monophora. 61
31926179 2020
5
Diagnostic value of fluorescein-labeled chitinase staining in formalin-fixed and paraffin-embedded tissues of fungal disease. 61
31329921 2020
6
Successful treatment of chromoblastomycosis caused by Fonsecaea pedrosoi using imiquimod. 61
31960479 2020
7
Case report: Fever- pneumonia- lymphadenectasis- osteolytic- subcutaneous nodule: Disseminated chromoblastomycosis caused by phialophora. 61
31229375 2019
8
Exophiala dermatitidis: Key issues of an opportunistic fungal pathogen. 61
30887863 2019
9
5-aminolevulinic acid-based photodynamic therapy associated with Itraconazole successfully treated a case of chromoblastomycosis. 61
31689509 2019
10
Dermoscopy of Chromoblastomycosis. 61
31807473 2019
11
Increased virulence of albino mutant of Fonsecaea monophora in Galleria mellonella. 61
30759240 2019
12
Photodynamic therapy combined with antifungal drugs against chromoblastomycosis and the effect of ALA-PDT on Fonsecaea in vitro. 61
31671098 2019
13
Mixed secondary bacterial infection is associated with severe lesions of chromoblastomycosis in a neglected population from Brazil. 61
31262546 2019
14
The Diagnosis of Fungal Neglected Tropical Diseases (Fungal NTDs) and the Role of Investigation and Laboratory Tests: An Expert Consensus Report. 61
31554262 2019
15
Chromoblastomycosis with a sporotrichoid distribution. 61
31368452 2019
16
A Rare Case of Chromoblastomycosis in a 12-year-old boy. 61
31511733 2019
17
Chromoblastomycosis caused by Rhinocladiella aquaspersa: first case report in Guatemala. 61
31780436 2019
18
Microbiological contamination in donor corneas preserved for medium-term. 61
31240495 2019
19
New Molecular Markers Distinguishing Fonsecaea Agents of Chromoblastomycosis. 61
31317385 2019
20
Intracranial fungal granuloma: a single-institute study of 90 cases over 18 years. 61
31370017 2019
21
Successful treatment of chromoblastomycosis using ALA-PDT in a patient with leukopenia. 61
30769166 2019
22
Endemic Mycoses in Children. 61
31205246 2019
23
Elbow Malformation with Osteoarthritis and Bone Destruction Caused by Chromoblastomycosis. 61
30955128 2019
24
Cutaneous chromoblastomycosis effectively treated with local heat monotherapy. 61
30280420 2019
25
[Long-pulsed 1064 nm Nd: YAG laser combined with terbinafine against chromoblastomycosis caused by Fonsecaea nubica and the effect of laser therapy in a Wistar rat model]. 61
31270051 2019
26
Synergistic effect of terbinafine and amphotericin B in killing Fonsecaea nubica in vitro and in vivo. 61
31241660 2019
27
Dermoscopic features in nodular chromoblastomycosis. 61
30565211 2019
28
Lymphocutaneous Sporotrichosis of Face with Verrucous Lesions: A Case Report. 61
31149578 2019
29
Next-generation sequencing for hypothesis-free genomic detection of invasive tropical infections in poly-microbially contaminated, formalin-fixed, paraffin-embedded tissue samples - a proof-of-principle assessment. 61
30961537 2019
30
Transcriptional profiling of macrophages infected with Fonsecaea monophora. 61
30656755 2019
31
A Case of Chromoblastomycosis Caused by Fonsecaea Pedrosoi and Investigation of the Pathogenic Fungi. 61
30701405 2019
32
Exophiala psychrophila: A new agent of chromoblastomycosis. 61
30533349 2019
33
In vitro susceptibility of chromoblastomycosis agents to antifungal drugs: A systematic review. 61
30266638 2019
34
Case Report: A Case of Chromoblastomycosis Caused by Fonsecaea pedrosoi in Vietnam. 61
29974323 2019
35
Chromoblastomycosis Caused by Fonsecaea nubica: First Report in Northern China and Literature Review. 61
30547378 2019
36
Chromoblastomycosis: an autochthonous case of a tropical disease. 61
30161267 2019
37
Melanin: Quantification and protection against oxidative stress in chromoblastomycosis agents. 61
29669009 2019
38
Cutaneous Chromoblastomycosis: A Prototypal Case. 61
30789034 2019
39
Chromoblastomycosis: a neglected disease. 61
31618325 2019
40
[Chromoblastomycosis in Mexico. A forgotten disease]. 61
30753765 2019
41
Study of tissue inflammatory response in different mice strains infected by dematiaceous fungi Fonsecaea pedrosoi. 61
30726460 2019
42
Identification of chromoblastomycosis agents by PCR based reverse line blot (PCR-RLB) hybridization assay. 61
30194974 2018
43
First case of chronic cutaneous chromoblastomycosis by Rhinocladiella similis aquired in Europe. 61
29885020 2018
44
An impressive case of chromoblastomycosis due to Fonsecaea pedrosoi in a patient with a long history of fungal infection. 61
30126716 2018
45
Chromoblastomycosis Caused by Phialophora verrucosa in a Costa Rican Child with Skin Sequelae due to Snake Bite. 61
30656078 2018
46
Melanization of a meristematic mutant of Fonsecaea monophora increase the pathogenesis in a BALB/c mice infection model. 61
29444317 2018
47
Chromoblastomycosis: clinical experience and review of literature. 61
30113072 2018
48
Epidemiology of Subcutaneous Mycoses in Northeast India: A Retrospective Study. 61
30504979 2018
49
Squamous cell carcinoma arising from a chromomycosis lesion caused by Rhinocladiella aquaspersa with postsurgical recurrence of chromomycosis. 61
30310837 2018
50
Chromoblastomycosis in immunosuppressed patients. 61
30257629 2018

Variations for Chromoblastomycosis

Expression for Chromoblastomycosis

Search GEO for disease gene expression data for Chromoblastomycosis.

Pathways for Chromoblastomycosis

Pathways related to Chromoblastomycosis according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.56 SYK MMP9 MMP1 IL4 HLA-A CLEC7A
2
Show member pathways
13.09 SYK MMP9 MMP1 IL4 HLA-A CCR1
3
Show member pathways
12.11 CXCR3 CCR6 CCR1 CCL3
4 11.96 SYK CLEC7A CLEC4E CARD9
5
Show member pathways
11.84 SYK CLEC7A CLEC6A CLEC4E CLEC4D CARD9
6 11.76 MMP9 MMP1 IL4
7
Show member pathways
11.74 IL4 HLA-A CCL3
8
Show member pathways
11.66 SYK CLEC6A CLEC4E CLEC4D
9 11.52 MMP9 IL4 CCL3
10 11.46 IL4 CXCR3 CCR6 CCL3
11 11.43 MMP9 IL4 CCL3
12
Show member pathways
11.34 SYK CLEC7A CLEC6A CLEC4E CLEC4D CARD9
13 11.23 IL4 CCR1 CCL3
14 10.77 MMP9 MMP1

GO Terms for Chromoblastomycosis

Biological processes related to Chromoblastomycosis according to GeneCards Suite gene sharing:

(show all 30)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.95 CXCR3 CLEC7A CCR1 CCL3
2 positive regulation of cell migration GO:0030335 9.88 MMP9 CLEC7A CCR1 CCL3
3 innate immune response GO:0045087 9.88 SYK CLEC7A CLEC6A CLEC4E CLEC4D CARD9
4 cytokine-mediated signaling pathway GO:0019221 9.83 MMP9 MMP1 IL4 CCR1 CCL3
5 chemotaxis GO:0006935 9.8 CXCR3 CCR6 CCR1 CCL3
6 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280 9.73 SYK CLEC7A CARD9
7 immune system process GO:0002376 9.7 SYK HLA-A CLEC7A CLEC6A CLEC4E CLEC4D
8 cell chemotaxis GO:0060326 9.67 CXCR3 CCR6 CCR1 CCL3
9 positive regulation of protein complex assembly GO:0031334 9.65 SYK MMP1 CLEC7A
10 positive regulation of tumor necrosis factor biosynthetic process GO:0042535 9.64 SYK CLEC7A
11 positive regulation of superoxide anion generation GO:0032930 9.64 SYK CLEC7A
12 positive regulation of calcium-mediated signaling GO:0050850 9.63 SYK CCL3
13 negative regulation of bone mineralization GO:0030502 9.63 CCR1 CCL3
14 positive regulation of cytokine secretion GO:0050715 9.63 SYK CLEC6A CLEC4E
15 dendritic cell chemotaxis GO:0002407 9.62 CCR6 CCR1
16 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.62 SYK CLEC7A
17 calcium-mediated signaling GO:0019722 9.62 CXCR3 CCR6 CCR1 CCL3
18 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.61 SYK CLEC7A
19 positive regulation of monocyte chemotactic protein-1 production GO:0071639 9.61 SYK CLEC7A
20 T cell chemotaxis GO:0010818 9.6 CXCR3 CCL3
21 pattern recognition receptor signaling pathway GO:0002221 9.59 CLEC7A CLEC4E
22 positive regulation of interleukin-12 biosynthetic process GO:0045084 9.58 SYK CLEC7A
23 positive regulation of killing of cells of other organism GO:0051712 9.57 SYK CLEC7A
24 chemokine-mediated signaling pathway GO:0070098 9.56 CXCR3 CCR6 CCR1 CCL3
25 cellular response to molecule of fungal origin GO:0071226 9.55 SYK CLEC7A
26 positive regulation of interleukin-10 biosynthetic process GO:0045082 9.54 SYK CLEC7A
27 Fc-gamma receptor signaling pathway GO:0038094 9.52 CLEC4E CLEC4D
28 T cell differentiation involved in immune response GO:0002292 9.51 CLEC4E CLEC4D
29 immune response GO:0006955 9.5 IL4 HLA-A CXCR3 CLEC4E CCR6 CCR1
30 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.02 SYK CLEC6A CLEC4E CLEC4D CARD9

Molecular functions related to Chromoblastomycosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 carbohydrate binding GO:0030246 9.62 CLEC7A CLEC6A CLEC4E CLEC4D
2 chemokine binding GO:0019956 9.43 CXCR3 CCR6 CCR1
3 C-C chemokine binding GO:0019957 9.33 CXCR3 CCR6 CCR1
4 C-C chemokine receptor activity GO:0016493 9.13 CXCR3 CCR6 CCR1
5 chemokine receptor activity GO:0004950 8.8 CXCR3 CCR6 CCR1

Sources for Chromoblastomycosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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