MCID: CHR082
MIFTS: 26

Chromophil Adenoma of the Kidney

Categories: Cancer diseases, Nephrological diseases

Aliases & Classifications for Chromophil Adenoma of the Kidney

MalaCards integrated aliases for Chromophil Adenoma of the Kidney:

Name: Chromophil Adenoma of the Kidney 12 15
Papillary Adenoma of the Kidney 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6257
NCIt 50 C3687
UMLS 71 C1518879

Summaries for Chromophil Adenoma of the Kidney

MalaCards based summary : Chromophil Adenoma of the Kidney, also known as papillary adenoma of the kidney, is related to papillary adenoma and renal cell carcinoma, papillary, 1. An important gene associated with Chromophil Adenoma of the Kidney is TFE3 (Transcription Factor Binding To IGHM Enhancer 3), and among its related pathways/superpathways are Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions and TNF signaling. Affiliated tissues include kidney, and related phenotypes are integument and liver/biliary system

Related Diseases for Chromophil Adenoma of the Kidney

Diseases related to Chromophil Adenoma of the Kidney via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 118)
# Related Disease Score Top Affiliating Genes
1 papillary adenoma 30.7 TFE3 KRT7 AMACR
2 renal cell carcinoma, papillary, 1 29.4 TFE3 PBRM1 MME KRT7 AMACR
3 renal cell carcinoma, nonpapillary 29.3 TFE3 PBRM1 MME KRT7 AMACR
4 type 1 papillary adenoma of the kidney 11.4
5 type 2 papillary adenoma of the kidney 11.4
6 adenoma 10.4
7 nephrogenic adenofibroma 10.3 TFE3 KRT7
8 ureteral benign neoplasm 10.2 SMIM20 KRT7
9 perivascular epithelioid cell tumor 10.2 TFE3 MME
10 bladder sarcoma 10.2 SMIM20 KRT7
11 nephrogenic adenoma 10.2 KRT7 AMACR
12 clear cell adenocarcinoma 10.2 KRT7 AMACR
13 bladder benign neoplasm 10.2 KRT7 AMACR
14 epithelial predominant wilms' tumor 10.2 KRT7 AMACR
15 urethral diverticulum 10.2 KRT7 AMACR
16 glandular cystitis 10.2 KRT7 AMACR
17 birt-hogg-dube syndrome 10.2 TFE3 KRT7
18 subareolar duct papillomatosis 10.2 MME KRT7
19 cervical mucinous adenocarcinoma 10.2 MME KRT7
20 nipple benign neoplasm 10.2 MME KRT7
21 pancreatic serous cystadenocarcinoma 10.2 MME KRT7
22 adenofibroma 10.1 MME KRT7
23 mixed epithelial stromal tumour 10.1 MME KRT7
24 urethra clear cell adenocarcinoma 10.1 KRT7 AMACR
25 epididymal neoplasm 10.1 MME KRT7
26 bladder adenocarcinoma 10.1 KRT7 AMACR
27 wolffian duct adenocarcinoma 10.1 MME KRT7
28 breast metaplastic carcinoma 10.1 MME KRT7
29 orbital cellulitis 10.1 MME KRT7
30 acute orbital inflammation 10.1 MME KRT7
31 balloon cell malignant melanoma 10.1 MME KRT7
32 ovarian mucinous adenocarcinoma 10.1 KRT7 AMACR
33 pulmonary artery leiomyosarcoma 10.1 MME KRT7
34 clear cell hidradenoma 10.1 MME KRT7
35 hidradenoma 10.1 MME KRT7
36 pancreatic mucinous cystadenoma 10.1 MME KRT7
37 cystadenofibroma 10.1 MME KRT7
38 seminal vesicle adenocarcinoma 10.1 KRT7 AMACR
39 squamous papillomatosis 10.1 MME KRT7
40 metanephric adenoma 10.1 KRT7 AMACR
41 cutaneous adenocystic carcinoma 10.1 MME KRT7
42 nasal cavity olfactory neuroblastoma 10.1 MME KRT7
43 ovarian sex-cord stromal tumor 10.1 MME KRT7
44 breast osteosarcoma 10.1 MME KRT7
45 cervical adenoma malignum 10.1 MME KRT7
46 epididymis adenocarcinoma 10.1 MME KRT7
47 epididymis cancer 10.1 MME KRT7
48 intraductal breast benign neoplasm 10.1 MME KRT7
49 breast benign neoplasm 10.1 MME KRT7
50 central epithelioid sarcoma 10.1 MME KRT7

Graphical network of the top 20 diseases related to Chromophil Adenoma of the Kidney:



Diseases related to Chromophil Adenoma of the Kidney

Symptoms & Phenotypes for Chromophil Adenoma of the Kidney

MGI Mouse Phenotypes related to Chromophil Adenoma of the Kidney:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.43 MME PTCH2 TFE3 TNF TNFRSF1A TNFRSF1B
2 liver/biliary system MP:0005370 9.1 AMACR MME PBRM1 TNF TNFRSF1A TNFRSF1B

Drugs & Therapeutics for Chromophil Adenoma of the Kidney

Search Clinical Trials , NIH Clinical Center for Chromophil Adenoma of the Kidney

Genetic Tests for Chromophil Adenoma of the Kidney

Anatomical Context for Chromophil Adenoma of the Kidney

MalaCards organs/tissues related to Chromophil Adenoma of the Kidney:

40
Kidney

Publications for Chromophil Adenoma of the Kidney

Articles related to Chromophil Adenoma of the Kidney:

# Title Authors PMID Year
1
Papillary adenoma of the kidney with mucinous secretion. 61
11332693 2001
2
[Tubular and papillary adenoma of the kidney]. 61
5533650 1970
3
[Papillary adenoma of the kidney]. 61
14841752 1951
4
[Papillary adenoma of the kidney]. 61
14774383 1950
5
Papillary adenoma of the kidney; renal hypertension. 61
18909827 1948
6
II. Malignant Papillary Adenoma of the Kidney. 61
17862757 1911

Variations for Chromophil Adenoma of the Kidney

Expression for Chromophil Adenoma of the Kidney

Search GEO for disease gene expression data for Chromophil Adenoma of the Kidney.

Pathways for Chromophil Adenoma of the Kidney

Pathways related to Chromophil Adenoma of the Kidney according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.05 TNFRSF1B TNFRSF1A TNF
2
Show member pathways
12.03 TNFRSF1B TNFRSF1A TNF
3 11.95 TNFRSF1B TNFRSF1A TNF
4 11.83 TNFRSF1A TNF MME
5 11.68 TNFRSF1B TNFRSF1A TNF
6
Show member pathways
11.52 TNFRSF1B TNFRSF1A TNF
7
Show member pathways
11.44 TNFRSF1B TNFRSF1A TNF
8 11.38 TNFRSF1B TNFRSF1A TNF
9 11.23 TNFRSF1B TNFRSF1A TNF
10 11.22 TNFRSF1A TNF
11 11.21 TNFRSF1A TNF
12 11.14 TNFRSF1A TNF
13
Show member pathways
11.14 TNFRSF1B TNFRSF1A TNF
14 11.07 TNFRSF1B TNFRSF1A
15 11.02 TNFRSF1B TNFRSF1A TNF
16 10.86 TNFRSF1A TNF
17
Show member pathways
10.69 TNFRSF1B TNFRSF1A TNF
18 10.3 TNFRSF1B TNFRSF1A TNF

GO Terms for Chromophil Adenoma of the Kidney

Cellular components related to Chromophil Adenoma of the Kidney according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane raft GO:0045121 9.26 TNFRSF1B TNFRSF1A TNF MME
2 tumor necrosis factor receptor superfamily complex GO:0002947 8.62 TNFRSF1B TNFRSF1A

Biological processes related to Chromophil Adenoma of the Kidney according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 tumor necrosis factor-mediated signaling pathway GO:0033209 9.63 TNFRSF1B TNFRSF1A TNF
2 extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 9.54 TNFRSF1A TNF
3 regulation of tumor necrosis factor-mediated signaling pathway GO:0010803 9.52 TNFRSF1A TNF
4 negative regulation of cardiac muscle hypertrophy GO:0010614 9.51 TNFRSF1B TNFRSF1A
5 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.49 TNFRSF1B TNF
6 regulation of osteoclast differentiation GO:0045670 9.48 TNF TFE3
7 positive regulation of ceramide biosynthetic process GO:2000304 9.43 TNFRSF1A TNF
8 regulation of establishment of endothelial barrier GO:1903140 9.4 TNFRSF1A TNF
9 death-inducing signaling complex assembly GO:0071550 9.37 TNFRSF1A TNF
10 aortic valve development GO:0003176 9.32 TNFRSF1B TNFRSF1A
11 negative regulation of extracellular matrix constituent secretion GO:0003332 9.26 TNFRSF1B TNFRSF1A
12 pulmonary valve development GO:0003177 9.16 TNFRSF1B TNFRSF1A
13 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.13 TNFRSF1B TNFRSF1A TNF
14 positive regulation of apoptotic process involved in morphogenesis GO:1902339 8.62 TNFRSF1B TNFRSF1A

Molecular functions related to Chromophil Adenoma of the Kidney according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tumor necrosis factor-activated receptor activity GO:0005031 8.96 TNFRSF1B TNFRSF1A
2 tumor necrosis factor binding GO:0043120 8.62 TNFRSF1B TNFRSF1A

Sources for Chromophil Adenoma of the Kidney

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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