MCID: CHR034
MIFTS: 44

Chromophobe Adenoma

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Chromophobe Adenoma

MalaCards integrated aliases for Chromophobe Adenoma:

Name: Chromophobe Adenoma 12 15 17
Adenoma, Chromophobe 45 74
Chromophobe Adenoma of the Pituitary Gland 12
Adenoma Chromophobe 56

Classifications:



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Disease Ontology 12 DOID:3828
MeSH 45 D000238
NCIt 51 C2857
SNOMED-CT 69 37039006
UMLS 74 C0001432

Summaries for Chromophobe Adenoma

MalaCards based summary : Chromophobe Adenoma, also known as adenoma, chromophobe, is related to pituitary tumors and galactorrhea. An important gene associated with Chromophobe Adenoma is PRL (Prolactin), and among its related pathways/superpathways are TGF-Beta Pathway and Peptide ligand-binding receptors. The drugs Hormones and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include pituitary, thyroid and ovary, and related phenotypes are endocrine/exocrine gland and liver/biliary system

Related Diseases for Chromophobe Adenoma

Diseases related to Chromophobe Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 115)
# Related Disease Score Top Affiliating Genes
1 pituitary tumors 30.7 GH1 POMC PRL
2 galactorrhea 30.6 PRL PRLR
3 conn's syndrome 30.5 CRH GH1 POMC PRL
4 chiasmal syndrome 30.4 GNRH1 POMC PRL
5 hyperthyroidism 30.2 GH1 INS PRL SERPINA7 TRH
6 craniopharyngioma 30.0 GH1 GNRH1 INS PRL TRH
7 pituitary apoplexy 30.0 GNRH1 INS POMC PRL
8 hypothyroidism 30.0 GH1 POMC PRL SERPINA7 TRH
9 acromegaly 29.7 GH1 GHRH INS POMC PRL TRH
10 diabetes insipidus 29.7 AVP CRH INS POMC PRL
11 hypopituitarism 29.1 CRH GH1 GHRH GNRH1 INS POMC
12 adenoma 11.0
13 fibrous dysplasia/mccune-albright syndrome 10.5 GH1 PRL
14 generalized resistance to thyroid hormone 10.4 PRL TRH
15 lymphocytic hypophysitis 10.4 GH1 POMC
16 postmenopausal atrophic vaginitis 10.4 POMC PRLR
17 hypogonadotropism 10.4 GNRH1 PRL
18 central nervous system germinoma 10.4 AVP POMC
19 suprasellar meningioma 10.4 POMC TRH
20 tuberculous epididymitis 10.4 AVP POMC
21 central precocious puberty 10.4 GH1 GNRH1
22 central nervous system germ cell tumor 10.4 AVP POMC
23 lung oat cell carcinoma 10.4 AVP POMC
24 bronchus cancer 10.3 AVP POMC
25 inappropriate adh syndrome 10.3 AVP POMC
26 pseudohypoparathyroidism, type ia 10.3 GH1 PRL TRH
27 pelvic varices 10.3 GNRH1 PRL
28 olfactory nerve neoplasm 10.3 AVP POMC
29 pituitary infarct 10.3 GNRH1 POMC PRL
30 secondary hypertrophic osteoarthropathy 10.3 AVP POMC
31 adrenal rest tumor 10.3 GNRH1 POMC PRL
32 scleredema adultorum 10.3 INS POMC
33 euthyroid sick syndrome 10.2 POMC SERPINA7
34 adenohypophysitis 10.2 GH1 POMC PRL TRH
35 pancreatic endocrine carcinoma 10.2 INS POMC
36 functioning pituitary adenoma 10.2 GH1 POMC PRL TRH
37 gigantism 10.2 GH1 GHRH PRL
38 secondary adrenal insufficiency 10.2 AVP INS
39 pituitary adenoma, prolactin-secreting 10.2 GH1 POMC PRL TRH
40 sella turcica neoplasm 10.2 GHRH POMC PRL
41 tuberculum sellae meningioma 10.2 GHRH POMC PRL
42 thyroid hormone resistance, generalized, autosomal dominant 10.2 SERPINA7 TRH
43 allergic encephalomyelitis 10.2 CRH POMC
44 mucinoses 10.2 INS POMC
45 breast disease 10.2 POMC PRL PRLR
46 gangliocytoma 10.2 CRH POMC
47 toxic diffuse goiter 10.2 SERPINA7 TRH
48 isolated growth hormone deficiency, type ib 10.2 GH1 GHRH
49 syndrome of inappropriate antidiuretic hormone 10.2 AVP POMC
50 thyroid crisis 10.2 POMC SERPINA7

Graphical network of the top 20 diseases related to Chromophobe Adenoma:



Diseases related to Chromophobe Adenoma

Symptoms & Phenotypes for Chromophobe Adenoma

MGI Mouse Phenotypes related to Chromophobe Adenoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.86 CRH GHRH GNRH1 INS POMC PRL
2 liver/biliary system MP:0005370 9.63 CRH GHRH GNRH1 INS POMC PRL
3 nervous system MP:0003631 9.61 AVP CRH GHRH GNRH1 INS POMC
4 renal/urinary system MP:0005367 9.1 AVP CRH FLCN GNRH1 INS POMC

Drugs & Therapeutics for Chromophobe Adenoma

Drugs for Chromophobe Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Hormones Phase 2,Phase 1
2
Dexamethasone Approved, Investigational, Vet_approved Phase 1 50-02-2 5743
3
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 1 1177-87-3
4
protease inhibitors Phase 1
5 Peripheral Nervous System Agents Phase 1
6 Hormone Antagonists Phase 1
7 Antiemetics Phase 1
8 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1
9 Gastrointestinal Agents Phase 1
10 Autonomic Agents Phase 1
11 HIV Protease Inhibitors Phase 1
12 glucocorticoids Phase 1
13 BB 1101 Phase 1
14 Anti-Inflammatory Agents Phase 1
15 Antineoplastic Agents, Hormonal Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Temozolomide in Treating Patients With Invasive Pituitary Tumors Withdrawn NCT00601289 Phase 2 temozolomide
2 Gamma-Secretase Inhibitor RO4929097 in Treating Young Patients With Relapsed or Refractory Solid Tumors, CNS Tumors, Lymphoma, or T-Cell Leukemia Terminated NCT01088763 Phase 1 gamma-secretase/Notch signalling pathway inhibitor RO4929097;dexamethasone

Search NIH Clinical Center for Chromophobe Adenoma

Cochrane evidence based reviews: adenoma, chromophobe

Genetic Tests for Chromophobe Adenoma

Anatomical Context for Chromophobe Adenoma

MalaCards organs/tissues related to Chromophobe Adenoma:

42
Pituitary, Thyroid, Ovary, T Cells, Skin, Testes, Cortex

Publications for Chromophobe Adenoma

Articles related to Chromophobe Adenoma:

(show top 50) (show all 99)
# Title Authors Year
1
An aged bull with concurrent thyroid C cell carcinoma, adrenal pheochromocytoma and pituitary chromophobe adenoma. ( 19262038 )
2009
2
Renal oncocytoma with t(5;12;11), der(1)1;8) and add(19): "true" oncocytoma or chromophobe adenoma? ( 9389566 )
1997
3
Non-functional pituitary chromophobe adenoma in a calf. ( 8878755 )
1996
4
Selective osmoreceptor dysfunction presenting as intermittent hypernatremia following surgery for a pituitary chromophobe adenoma. ( 3728518 )
1986
5
Pituitary Cushing's disease arising from a previously non-functional corticotrophic chromophobe adenoma. ( 2985300 )
1985
6
Spontaneous hemorrhagic necrosis of chromophobe adenoma with clinical presentations simulating rupture of aneurysm. ( 7077217 )
1982
7
Squamous metaplasia following necrosis of the adenohypophysis and of a chromophobe adenoma of the pituitary. ( 7080436 )
1982
8
Hypothyroidism secondary to biologically inactive thyroid-stimulating hormone secretion by a pituitary chromophobe adenoma: recovery after removal of the tumor. ( 7103637 )
1982
9
Collection of gas within a huge chromophobe adenoma. A case report. ( 7121823 )
1982
10
Host factors in "chromophobe" adenoma of the anterior pituitary: a retrospective study of 464 patients. ( 6782424 )
1981
11
Multiple myeloma masquerading as chromophobe adenoma. ( 445346 )
1979
12
Chromophobe adenoma of the pituitary with Cushing's syndrome and skin pigmentation. ( 514937 )
1979
13
Variations in LH and FSH serum gonadotropins in the hypophyseal chromophobe adenoma and acromegaly in the woman in relation to age. ( 675127 )
1978
14
Ultrastructure of capillaries in chromophobe adenoma. ( 714208 )
1978
15
Cytoplasmic filamentous masses in chromophobe adenoma of the human pituitary gland. ( 722396 )
1978
16
Malignant pituitary chromophobe adenoma in an infant accompanying diabetes insipidus. ( 735828 )
1978
17
Galactorrhea in a 12-year-old boy with a chromophobe adenoma. ( 558298 )
1977
18
An autopsy case of pituitary chromophobe adenoma. ( 614080 )
1977
19
Case report. Tandem lesions: chromophobe adenoma and meningioma. ( 615235 )
1977
20
Ultrastructure of chromophobe adenoma of the human pituitary gland. ( 915598 )
1977
21
An unusual case of chromophobe adenoma with conspicuous calcifications. ( 920311 )
1977
22
Chromophobe adenoma and chiasmal syndrome without enlargement of the bony sella. ( 970854 )
1976
23
McCune-Albright syndrome associated with a functioning pituitary chromophobe adenoma. ( 932906 )
1976
24
Third ventricular chromophobe adenoma with normal adenohypophysis. ( 961385 )
1976
25
Chromophobe adenoma manifesting as a nasopharyngeal mass. ( 971137 )
1976
26
The fine structure of a prolactin-rich pituitary chromophobe adenoma (a case report). ( 977384 )
1976
27
Nasal obstruction caused by a pituitary chromophobe adenoma. ( 979497 )
1976
28
Pathophysiological and pathogenic interpretation of the clinical picture of chromophobe adenoma of the hypophysis and of craniopharyngioma. ( 1053393 )
1976
29
Calcification in a chromophobe adenoma. Case report. ( 1262925 )
1976
30
Case of hyperthyroidism due to a chromophobe adenoma. ( 1269160 )
1976
31
The diagnostic problem of multiple intracranial tumours--case report of a pituitary chromophobe adenoma and cerebellar haemangioblastoma. ( 1240630 )
1975
32
Chromophobe adenoma masquerading as corticosteroid-responsive optic neuritis. ( 4369864 )
1974
33
The role of visual fields and visual acuity in the treatment of chromophobe adenoma of the pituitary gland. A case report. ( 4423942 )
1974
34
Case report: spontaneous intracranial "aerocoele" with chromophobe adenoma. ( 4433985 )
1974
35
Familial polyposis and pituitary chromophobe adenoma. ( 4528562 )
1974
36
Effects of surgical treatment on hypothalamo-pituitary-adrenocortical functions in pituitary chromophobe adenoma and craniopharyngioma. ( 4548402 )
1974
37
Chromophobe adenoma presenting with a hemianopic temporal arcuate scotoma. ( 4813313 )
1974
38
Chromophobe adenoma of the pituitary gland masquerading as bilateral nasal polypi--report of a case. ( 4818288 )
1974
39
Pituitary "chromophobe" adenoma composed of oncocytes. A light and electron microscopic study. ( 4121198 )
1973
40
Chromophobe adenoma of pituitary with acromegaly and acoustic neurinoma occurring in the same patient. A case report and review of the literature. ( 4539438 )
1973
41
Chromophobe adenoma of pituitary--the silent lesion. A case report. ( 4540952 )
1973
42
Pituitary chromophobe adenoma in a cat. ( 4779122 )
1973
43
Laser perimetry: diagnostic application in six cases of pituitary chromophobe adenoma. ( 4801814 )
1973
44
The fine structure of blood vessels in chromophobe adenoma. ( 4673965 )
1972
45
Fulminant meningitis associated with asymptomatic chromophobe adenoma. ( 5017859 )
1972
46
Metastasis of mammary carcinoma in a chromophobe adenoma of the hypophysis. ( 5138127 )
1971
47
Aldosterone secretion and plasma renin activity in chromophobe adenoma: effect of acth. ( 4320036 )
1970
48
Asymptomatic chromophobe adenoma in an eight-year-old child biopsied by stereotaxic technique and treated with cobalt-60. Case report. ( 4908799 )
1970
49
Chromophobe adenoma in a dog. ( 5202559 )
1970
50
Hyperthyroidism due to thyrotropin-producing pituitary chromophobe adenoma. ( 5470849 )
1970

Variations for Chromophobe Adenoma

Expression for Chromophobe Adenoma

Search GEO for disease gene expression data for Chromophobe Adenoma.

Pathways for Chromophobe Adenoma

Pathways related to Chromophobe Adenoma according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.28 GH1 GH2 GHRH GNRH1 INS PRL
2
Show member pathways
12.94 AVP CRH GH1 GH2 GHRH GNRH1
3
Show member pathways
12.83 GH1 GH2 GHRH GNRH1 INS
4
Show member pathways
12.8 CRH GH1 GH2 GHRH POMC
5
Show member pathways
12.71 GH1 GH2 INS PRL PRLR
6
Show member pathways
12.48 GH1 GH2 GHRH GNRH1
7
Show member pathways
12.12 GH1 INS PRL PRLR
8
Show member pathways
12.07 GH1 GH2 PRL PRLR
9
Show member pathways
11.97 GH1 GH2 GHRH GNRH1
10 11.82 GH1 INS PRLR
11
Show member pathways
11.82 GH1 GH2 GHRH GNRH1
12 11.62 AVP CRH GHRH POMC
13 11.42 GH1 GH2 GHRH GNRH1
14 11.13 INS PRL PRLR
15
Show member pathways
10.54 GH1 GH2 PRL PRLR
16 10.17 CRH POMC

GO Terms for Chromophobe Adenoma

Cellular components related to Chromophobe Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.85 AVP CRH GH1 GH2 GHRH GNRH1
2 extracellular region GO:0005576 9.73 AVP CRH GH1 GH2 GHRH GNRH1
3 perikaryon GO:0043204 9.5 CRH GHRH GNRH1
4 secretory granule GO:0030141 9.43 AVP POMC TRH
5 endosome lumen GO:0031904 9.02 GH1 GH2 INS PRL PRLR

Biological processes related to Chromophobe Adenoma according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor signaling pathway GO:0007186 9.98 AVP CRH GHRH GNRH1 INS POMC
2 positive regulation of cell proliferation GO:0008284 9.91 AVP CRH GHRH INS PRL
3 female pregnancy GO:0007565 9.74 CRH GNRH1 PRL
4 response to nutrient levels GO:0031667 9.63 GH1 GH2 PRL
5 cell-cell signaling GO:0007267 9.63 AVP GHRH GNRH1 INS POMC TRH
6 response to corticosterone GO:0051412 9.58 CRH TRH
7 animal organ development GO:0048513 9.58 GH1 GH2
8 positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 9.56 GH1 GHRH
9 response to ethanol GO:0045471 9.56 AVP CRH GNRH1 TRH
10 growth hormone receptor signaling pathway GO:0060396 9.55 GH1 GH2
11 positive regulation of growth GO:0045927 9.54 GH1 GH2
12 response to organic cyclic compound GO:0014070 9.54 AVP GNRH1 TRH
13 positive regulation of JAK-STAT cascade GO:0046427 9.5 GH1 GH2 PRL
14 negative regulation of feeding behavior GO:2000252 9.48 INS TRH
15 regulation of signaling receptor activity GO:0010469 9.28 AVP GH1 GH2 GHRH GNRH1 INS
16 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 9.26 GH1 GH2 PRL PRLR
17 parturition GO:0007567 9.22 CRH
18 ovulation cycle GO:0042698 9.19 GNRH1
19 positive regulation of lactation GO:1903489 9.1 PRL

Molecular functions related to Chromophobe Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuropeptide hormone activity GO:0005184 9.33 AVP CRH GHRH
2 growth hormone receptor binding GO:0005131 9.32 GH1 GH2
3 hormone activity GO:0005179 9.28 AVP CRH GH1 GH2 GNRH1 INS
4 basic amino acid transmembrane transporter activity GO:0015174 9.26 SLC7A3 SLC7A4
5 prolactin receptor binding GO:0005148 8.96 GH1 PRL

Sources for Chromophobe Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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