MCID: CHR034
MIFTS: 33

Chromophobe Adenoma

Categories: Cancer diseases, Endocrine diseases
Data Licensing
For inquiries, contact:

Aliases & Classifications for Chromophobe Adenoma

MalaCards integrated aliases for Chromophobe Adenoma:

Name: Chromophobe Adenoma 11 14 16
Adenoma, Chromophobe 43 71
Chromophobe Adenoma of the Pituitary Gland 11
Adenoma Chromophobe 53

Classifications:



External Ids:

Disease Ontology 11 DOID:3828
MeSH 43 D000238
NCIt 49 C2857
SNOMED-CT 68 37039006
UMLS 71 C0001432

Summaries for Chromophobe Adenoma

MalaCards based summary: Chromophobe Adenoma, also known as adenoma, chromophobe, is related to adenoma and graves disease 1. An important gene associated with Chromophobe Adenoma is PRL (Prolactin), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Thyroid hormones production and peripheral downstream signaling effects. The drugs Dexamethasone acetate and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include pituitary, temporal lobe and thyroid.

Related Diseases for Chromophobe Adenoma

Diseases related to Chromophobe Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 133)
# Related Disease Score Top Affiliating Genes
1 adenoma 31.2 TRH PRL POMC GH1
2 graves disease 1 30.6 TRH POMC
3 pituitary adenoma 30.5 TRH PRL POMC GH1
4 pituitary tumors 30.5 PRL GH1
5 chiasmal syndrome 30.4 PRL POMC
6 diabetes insipidus 30.3 PRL POMC GH1
7 mccune-albright syndrome 30.2 PRL POMC GH1
8 conn's syndrome 30.2 TRH PRL POMC GH1
9 galactorrhea 30.2 PRLR PRL
10 craniopharyngioma 30.2 TRH PRL GH1
11 premature ovarian failure 7 30.1 POMC GH1
12 hyperthyroidism 30.1 TRH PRL POMC GH1
13 nelson syndrome 30.1 PRL POMC
14 pituitary-dependent cushing's disease 30.1 TRH PRL POMC GH1
15 hypopituitarism 30.0 TRH PRL POMC GH1
16 gynecomastia 29.9 PRL POMC
17 central diabetes insipidus 29.9 TRH PRL POMC GH1
18 pituitary hormone deficiency, combined, 2 29.9 TRH PRL POMC GH1
19 hypogonadism 29.8 PRL POMC GH1
20 amenorrhea 29.8 TRH PRL POMC
21 pituitary apoplexy 29.8 TRH PRL POMC GH1
22 acromegaly 29.6 TRH PRLR PRL POMC GH1
23 hypothyroidism 29.5 TRH PRL POMC GH1
24 hyperprolactinemia 29.3 TRH PRLR PRL POMC GH1
25 meningioma, familial 29.3 PRLR PRL POMC
26 prolactinoma 29.3 TRH PRLR PRL POMC GH1
27 pituitary gland disease 28.9 TRH PRLR PRL POMC GH1
28 tuberculum sellae meningioma 10.2 PRL POMC
29 sella turcica neoplasm 10.2 PRL POMC
30 prolactin producing pituitary tumor 10.2 PRL POMC
31 ectopic cushing syndrome 10.2 PRL POMC
32 tsh producing pituitary tumor 10.2 PRL POMC
33 abducens palsy 10.2 PRL POMC
34 pituitary adenoma 1, multiple types 10.2 PRL GH1
35 melanotic neurilemmoma 10.2 PRL POMC
36 gangliocytoma 10.2 PRL POMC
37 sexual sadism 10.1 PRL POMC
38 lactocele 10.1 TRH PRL
39 cranial nerve palsy 10.1 PRL POMC
40 pituitary hypoplasia 10.1 PRL POMC
41 mixed cerebral palsy 10.1 TRH PRL
42 hormone producing pituitary cancer 10.1 PRL POMC
43 pituitary cancer 10.1 PRL POMC
44 hypothyroidism, central, with testicular enlargement 10.1 TRH PRL
45 inappropriate adh syndrome 10.1 PRL POMC
46 steroid inherited metabolic disorder 10.1 PRL POMC
47 postpartum depression 10.1 PRL POMC
48 suprasellar meningioma 10.1 TRH POMC
49 acth-secreting pituitary adenoma 10.1 PRL POMC
50 17-beta hydroxysteroid dehydrogenase iii deficiency 10.1 POMC GH1

Graphical network of the top 20 diseases related to Chromophobe Adenoma:



Diseases related to Chromophobe Adenoma

Symptoms & Phenotypes for Chromophobe Adenoma

Drugs & Therapeutics for Chromophobe Adenoma

Drugs for Chromophobe Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 1 1177-87-3 3680
2
Dexamethasone Approved, Investigational, Vet_approved Phase 1 50-02-2 3003 5743
3 Antineoplastic Agents, Hormonal Phase 1
4 R04929097 Phase 1
5 Hormones Phase 1
6 Hormone Antagonists Phase 1
7 Antiemetics Phase 1
8 glucocorticoids Phase 1
9 BB 1101 Phase 1
10 Anti-Inflammatory Agents Phase 1
11 Gastrointestinal Agents Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A PHASE 1/2 STUDY OF RO4929097, AN ORAL SMALL MOLECULE INHIBITOR OF GAMMA-SECRETASE, IN CHILDREN WITH RELAPSED/REFRACTORY SOLID OR CNS TUMORS, LYMPHOMA, OR T-CELL LEUKEMIA Terminated NCT01088763 Phase 1 gamma-secretase/Notch signalling pathway inhibitor RO4929097;dexamethasone

Search NIH Clinical Center for Chromophobe Adenoma

Cochrane evidence based reviews: adenoma, chromophobe

Genetic Tests for Chromophobe Adenoma

Anatomical Context for Chromophobe Adenoma

Organs/tissues related to Chromophobe Adenoma:

MalaCards : Pituitary, Temporal Lobe, Thyroid, Spinal Cord, Hypothalamus, Brain, Prostate

Publications for Chromophobe Adenoma

Articles related to Chromophobe Adenoma:

(show top 50) (show all 303)
# Title Authors PMID Year
1
Long-standing goiter and hypothyroidism: an unusual presentation of a TSH-secreting adenoma. 53 62
8875756 1996
2
A null cell adenoma of the pituitary detected seven years after removal of a prolactinoma. Recurrence or de novo tumourigenesis? 53 62
1789066 1991
3
[A case of fibrous dysplasia (McCune Albright syndrome) associated with acromegaly]. 53 62
2070893 1991
4
Natural history of pituitary apoplexy: a long-term follow-up study. 62
35701171 2022
5
Pituitary carcinomas: review of the current literature and report of atypical case. 62
30836020 2020
6
Cluster headache associated with a clinically non-functioning pituitary adenoma: a case report. 62
25526868 2014
7
An aged bull with concurrent thyroid C cell carcinoma, adrenal pheochromocytoma and pituitary chromophobe adenoma. 62
19262038 2009
8
Safety of GH replacement in hypopituitary patients with nonirradiated pituitary and peripituitary tumours. 62
18031317 2008
9
A pituitary carcinoma secreting TSH and prolactin: a non-secreting adenoma gone awry. 62
16645009 2006
10
Subclinical Cushings disease with amelioration of metabolic comorbidities after removal of pituitary tumor. 62
17139124 2006
11
Massive reduction of tumour load and normalisation of hyperprolactinaemia after high dose cabergoline in metastasised prolactinoma causing thoracic syringomyelia. 62
15377706 2004
12
Acute sterile meningitis as a primary manifestation of pituitary apoplexy. 62
14669831 2003
13
Review of renal oncocytoma with focus on clinical and pathobiological aspects. 62
12792905 2003
14
[Macroadenoma of the pituitary gland with moderate hyperprolactinaemia]. 62
12660899 2003
15
Review of chromophobe renal cell carcinoma with focus on clinical and pathobiological aspects. 62
12507296 2003
16
[Silent adenoma type 3: the importance of the ultrastructural study in the differential diagnosis of pituitary adenoma associated with hyperprolactinemia in a case]. 62
11372297 2001
17
Genetic heterogeneity and alterations in chromosome 9 loci in a localized region of a functional pituitary adenoma. 53
11297766 2001
18
Non-functioning pituitary adenomas: indications for postoperative radiotherapy. 62
11155093 2000
19
[Gonadotroph pituitary adenomas]. 62
10970952 2000
20
Retinitis pigmentosa in association with acromegaly: a case report. 62
10947002 1999
21
An ACTH-producing pituitary carcinoma developing Cushing's disease. 62
10220799 1999
22
Mitotane (o,p'-DDD) resistance in a dog with pituitary-dependent hyperadrenocorticism and phaeochromocytoma. 62
9578778 1998
23
Pituitary tumours. 62
10771953 1998
24
Renal oncocytoma with t(5;12;11), der(1)1;8) and add(19): "true" oncocytoma or chromophobe adenoma? 62
9389566 1997
25
Herniation of the third ventricle into empty sella caused by surgery for pituitary apoplexy--case report. 62
8741375 1996
26
Non-functional pituitary chromophobe adenoma in a calf. 62
8878755 1996
27
[A case of pituitary adenoma progressing to pituitary apoplexy on the occasion of cerebral angiography]. 62
8692376 1996
28
[TSH-secreting fibrous pituitary adenoma showing calcification: a case report]. 62
7700496 1995
29
Transnasal stereotactic surgery of pituitary adenomas concomitant with acromegaly. 62
8916351 1995
30
Pituitary apoplexy caused by endocrine stimulation tests: a case report. 62
7940090 1994
31
Cushing's syndrome caused by an ectopic pituitary adenoma of the sphenoid sinus: Adrenal crisis after partial resections of the adenoma. 62
32138443 1994
32
[A juvenile male prolactinoma: a case report]. 62
8474593 1993
33
Pituitary dependent hyperadrenocorticism in a cat. 62
1477172 1992
34
An aetiological profile of optic atrophy. 62
1488877 1992
35
Parathyroid carcinoma in a patient with non-secretory pituitary tumor: a variant of multiple endocrine neoplasia type-I? 62
1358678 1992
36
Moyamoya disease associated with pituitary adenoma--report of two cases. 62
1280777 1992
37
Hyperadrenocorticism in four cats. 62
1413443 1992
38
[A case of pituitary adenoma and hyperplasia with primary hypothyroidism]. 62
1896118 1991
39
Pituitary apoplexy presenting as aseptic meningitis without visual loss or ophthalmoplegia. 62
2222354 1990
40
Combined anterior pituitary function test using CRH, GRH, LH-RH, TRH and vasopressin in patients with non-functioning pituitary tumors. 62
2200236 1990
41
[The reaction of the hypophysis to thyroliberin and metoclopramide in women with hyperprolactinemia]. 53
2114023 1990
42
Ptosis as the early manifestation of pituitary tumour. 62
2322519 1990
43
[Pituitary apoplexy with hypercreatinekinasemia]. 62
2350934 1990
44
Hyperthyroidism with an FSH-and TSH-secreting pituitary adenoma. 62
2482837 1989
45
[An intracranial collision tumor composed of intrasellar gangliocytoma and pituitary adenoma]. 62
2693987 1989
46
A case of hypopituitarism and type V hyperlipidemia. 62
2585891 1989
47
[Dopaminergic regulation of the hypothalamo-hypophyseal system in patients with hypophyseal adenomas]. 62
2587520 1989
48
[FSH, LH, prolactin and testosterone levels in peripheral blood and urinary excretion of 17-ketosteroids and 17-hydroxycorticosteroids in patients after removal of chromophobe adenoma of the pituitary gland]. 62
2641804 1989
49
[A case of pituitary adenoma presenting binasal inferior quadrants hemianopsia]. 62
2615906 1989
50
Dynamic CT scan of intracranial tumors. 62
2512067 1989

Variations for Chromophobe Adenoma

Expression for Chromophobe Adenoma

Search GEO for disease gene expression data for Chromophobe Adenoma.

Pathways for Chromophobe Adenoma

GO Terms for Chromophobe Adenoma

Cellular components related to Chromophobe Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endosome lumen GO:0031904 9.1 PRLR PRL GH1

Biological processes related to Chromophobe Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor signaling pathway via JAK-STAT GO:0007259 9.46 PRLR GH1
2 lactation GO:0007595 9.26 PRLR PRL
3 positive regulation of receptor signaling pathway via JAK-STAT GO:0046427 8.92 PRL GH1

Molecular functions related to Chromophobe Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 amino acid transmembrane transporter activity GO:0015171 9.56 SLC7A4 SLC7A3
2 basic amino acid transmembrane transporter activity GO:0015174 9.33 SLC7A4 SLC7A3
3 prolactin receptor binding GO:0005148 9.26 PRL GH1
4 hormone activity GO:0005179 9.17 TRH PRL POMC GH1

Sources for Chromophobe Adenoma

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....