MCID: CHR034
MIFTS: 34

Chromophobe Adenoma

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Chromophobe Adenoma

MalaCards integrated aliases for Chromophobe Adenoma:

Name: Chromophobe Adenoma 12 15 17
Adenoma, Chromophobe 43 71
Chromophobe Adenoma of the Pituitary Gland 12
Adenoma Chromophobe 54

Classifications:



External Ids:

Disease Ontology 12 DOID:3828
MeSH 43 D000238
NCIt 49 C2857
SNOMED-CT 67 37039006
UMLS 71 C0001432

Summaries for Chromophobe Adenoma

MalaCards based summary : Chromophobe Adenoma, also known as adenoma, chromophobe, is related to adenoma and pituitary tumors. An important gene associated with Chromophobe Adenoma is PRL (Prolactin), and among its related pathways/superpathways are Peptide ligand-binding receptors and JAK-STAT signaling pathway. The drugs Dexamethasone acetate and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include pituitary, t cells and thyroid, and related phenotype is neoplasm.

Related Diseases for Chromophobe Adenoma

Diseases related to Chromophobe Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 145)
# Related Disease Score Top Affiliating Genes
1 adenoma 31.3 TRH PRL POMC GH1
2 pituitary tumors 30.5 PRL POMC GH1
3 mccune-albright syndrome 30.4 PRL GH1
4 diabetes insipidus 30.4 PRL POMC GH1
5 galactorrhea 30.3 PRLR PRL
6 craniopharyngioma 30.3 TRH PRL GH1
7 gynecomastia 30.2 PRL POMC
8 hyperthyroidism 30.1 TRH PRL POMC GH1
9 impotence 30.1 PRL POMC
10 pituitary adenoma 30.0 TRH PRL POMC GH1
11 hypopituitarism 29.9 TRH PRL POMC GH1
12 hypoglycemia 29.9 PRL POMC GH1
13 amenorrhea 29.9 TRH PRL POMC
14 hypothyroidism 29.8 TRH PRL POMC GH1
15 pituitary apoplexy 29.7 TRH PRL POMC GH1
16 pituitary hormone deficiency, combined, 2 29.7 TRH PRL POMC GH1
17 pituitary adenoma, prolactin-secreting 29.5 TRH PRL POMC GH1
18 pheochromocytoma 29.3 PRL POMC CDKN2C
19 acromegaly 29.2 TRH PRLR PRL POMC GH1
20 hyperprolactinemia 28.9 TRH PRLR PRL POMC GH1
21 pituitary gland disease 28.6 TRH PRLR PRL POMC GH1
22 fibrous dysplasia 10.3 PRL GH1
23 fibrous dysplasia/mccune-albright syndrome 10.3 PRL GH1
24 gigantism 10.3 PRL GH1
25 tsh producing pituitary tumor 10.3 PRL GH1
26 tetrahydrobiopterin deficiency 10.3 PRL GH1
27 acth-dependent cushing syndrome 10.3 PRL POMC
28 tuberculum sellae meningioma 10.3 PRL POMC
29 sella turcica neoplasm 10.3 PRL POMC
30 pituitary stalk interruption syndrome 10.3 PRL GH1
31 prolactin producing pituitary tumor 10.3 PRL POMC
32 lymphocytic hypophysitis 10.2 POMC GH1
33 pseudohypoparathyroidism 10.2 TRH PRL
34 abducens nerve disease 10.2 PRL POMC
35 hormone producing pituitary cancer 10.2 PRL POMC
36 meningitis 10.2
37 generalized resistance to thyroid hormone 10.2 TRH PRL
38 sheehan syndrome 10.2 PRL POMC
39 gangliocytoma 10.2 PRL POMC
40 nelson syndrome 10.2 PRL POMC
41 cranial nerve palsy 10.2 PRL POMC
42 pituitary hypoplasia 10.2 PRL GH1
43 melancholia 10.2 PRL POMC
44 pituitary adenoma 1, multiple types 10.2 PRL GH1
45 hypothyroidism, central, with testicular enlargement 10.2 TRH PRL
46 acth-secreting pituitary adenoma 10.2 PRL POMC
47 pituitary carcinoma 10.2 PRL POMC
48 steroid inherited metabolic disorder 10.2 PRL POMC
49 intracranial hypertension, idiopathic 10.2 POMC GH1
50 growth hormone secreting pituitary adenoma 10.2 PRL POMC

Graphical network of the top 20 diseases related to Chromophobe Adenoma:



Diseases related to Chromophobe Adenoma

Symptoms & Phenotypes for Chromophobe Adenoma

MGI Mouse Phenotypes related to Chromophobe Adenoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 8.92 CDKN2C POMC PRL PRLR

Drugs & Therapeutics for Chromophobe Adenoma

Drugs for Chromophobe Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 1 1177-87-3
2
Dexamethasone Approved, Investigational, Vet_approved Phase 1 50-02-2 5743
3 Gastrointestinal Agents Phase 1
4 Antineoplastic Agents, Hormonal Phase 1
5 Antiemetics Phase 1
6 Hormone Antagonists Phase 1
7 glucocorticoids Phase 1
8 BB 1101 Phase 1
9 Anti-Inflammatory Agents Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 An Open Label, Multicenter, Phase II Study Evaluating the Safety and Efficacy of Temozolomide Treatment in Patients With Invasive Pituitary Tumors Withdrawn NCT00601289 Phase 2 temozolomide
2 A PHASE 1/2 STUDY OF RO4929097, AN ORAL SMALL MOLECULE INHIBITOR OF GAMMA-SECRETASE, IN CHILDREN WITH RELAPSED/REFRACTORY SOLID OR CNS TUMORS, LYMPHOMA, OR T-CELL LEUKEMIA Terminated NCT01088763 Phase 1 gamma-secretase/Notch signalling pathway inhibitor RO4929097;dexamethasone

Search NIH Clinical Center for Chromophobe Adenoma

Cochrane evidence based reviews: adenoma, chromophobe

Genetic Tests for Chromophobe Adenoma

Anatomical Context for Chromophobe Adenoma

MalaCards organs/tissues related to Chromophobe Adenoma:

40
Pituitary, T Cells, Thyroid, Testes, Brain, Eye, Bone

Publications for Chromophobe Adenoma

Articles related to Chromophobe Adenoma:

(show top 50) (show all 302)
# Title Authors PMID Year
1
Long-standing goiter and hypothyroidism: an unusual presentation of a TSH-secreting adenoma. 54 61
8875756 1996
2
A null cell adenoma of the pituitary detected seven years after removal of a prolactinoma. Recurrence or de novo tumourigenesis? 54 61
1789066 1991
3
[A case of fibrous dysplasia (McCune Albright syndrome) associated with acromegaly]. 61 54
2070893 1991
4
Pituitary carcinomas: review of the current literature and report of atypical case. 61
30836020 2019
5
Cluster headache associated with a clinically non-functioning pituitary adenoma: a case report. 61
25526868 2014
6
An aged bull with concurrent thyroid C cell carcinoma, adrenal pheochromocytoma and pituitary chromophobe adenoma. 61
19262038 2009
7
Safety of GH replacement in hypopituitary patients with nonirradiated pituitary and peripituitary tumours. 61
18031317 2008
8
A pituitary carcinoma secreting TSH and prolactin: a non-secreting adenoma gone awry. 61
16645009 2006
9
Subclinical Cushings disease with amelioration of metabolic comorbidities after removal of pituitary tumor. 61
17139124 2006
10
Massive reduction of tumour load and normalisation of hyperprolactinaemia after high dose cabergoline in metastasised prolactinoma causing thoracic syringomyelia. 61
15377706 2004
11
Acute sterile meningitis as a primary manifestation of pituitary apoplexy. 61
14669831 2003
12
Review of renal oncocytoma with focus on clinical and pathobiological aspects. 61
12792905 2003
13
[Macroadenoma of the pituitary gland with moderate hyperprolactinaemia]. 61
12660899 2003
14
Review of chromophobe renal cell carcinoma with focus on clinical and pathobiological aspects. 61
12507296 2003
15
[Silent adenoma type 3: the importance of the ultrastructural study in the differential diagnosis of pituitary adenoma associated with hyperprolactinemia in a case]. 61
11372297 2001
16
Genetic heterogeneity and alterations in chromosome 9 loci in a localized region of a functional pituitary adenoma. 54
11297766 2001
17
Non-functioning pituitary adenomas: indications for postoperative radiotherapy. 61
11155093 2000
18
[Gonadotroph pituitary adenomas]. 61
10970952 2000
19
Retinitis pigmentosa in association with acromegaly: a case report. 61
10947002 1999
20
An ACTH-producing pituitary carcinoma developing Cushing's disease. 61
10220799 1999
21
Mitotane (o,p'-DDD) resistance in a dog with pituitary-dependent hyperadrenocorticism and phaeochromocytoma. 61
9578778 1998
22
Pituitary tumours. 61
10771953 1998
23
Renal oncocytoma with t(5;12;11), der(1)1;8) and add(19): "true" oncocytoma or chromophobe adenoma? 61
9389566 1997
24
Herniation of the third ventricle into empty sella caused by surgery for pituitary apoplexy--case report. 61
8741375 1996
25
Non-functional pituitary chromophobe adenoma in a calf. 61
8878755 1996
26
[A case of pituitary adenoma progressing to pituitary apoplexy on the occasion of cerebral angiography]. 61
8692376 1996
27
[TSH-secreting fibrous pituitary adenoma showing calcification: a case report]. 61
7700496 1995
28
Transnasal stereotactic surgery of pituitary adenomas concomitant with acromegaly. 61
8916351 1995
29
Pituitary apoplexy caused by endocrine stimulation tests: a case report. 61
7940090 1994
30
Cushing's syndrome caused by an ectopic pituitary adenoma of the sphenoid sinus: Adrenal crisis after partial resections of the adenoma. 61
32138443 1994
31
[A juvenile male prolactinoma: a case report]. 61
8474593 1993
32
An aetiological profile of optic atrophy. 61
1488877 1992
33
Pituitary dependent hyperadrenocorticism in a cat. 61
1477172 1992
34
Parathyroid carcinoma in a patient with non-secretory pituitary tumor: a variant of multiple endocrine neoplasia type-I? 61
1358678 1992
35
Moyamoya disease associated with pituitary adenoma--report of two cases. 61
1280777 1992
36
Hyperadrenocorticism in four cats. 61
1413443 1992
37
[A case of pituitary adenoma and hyperplasia with primary hypothyroidism]. 61
1896118 1991
38
Pituitary apoplexy presenting as aseptic meningitis without visual loss or ophthalmoplegia. 61
2222354 1990
39
Combined anterior pituitary function test using CRH, GRH, LH-RH, TRH and vasopressin in patients with non-functioning pituitary tumors. 61
2200236 1990
40
[The reaction of the hypophysis to thyroliberin and metoclopramide in women with hyperprolactinemia]. 54
2114023 1990
41
Ptosis as the early manifestation of pituitary tumour. 61
2322519 1990
42
[Pituitary apoplexy with hypercreatinekinasemia]. 61
2350934 1990
43
[An intracranial collision tumor composed of intrasellar gangliocytoma and pituitary adenoma]. 61
2693987 1989
44
Hyperthyroidism with an FSH-and TSH-secreting pituitary adenoma. 61
2482837 1989
45
A case of hypopituitarism and type V hyperlipidemia. 61
2585891 1989
46
[Dopaminergic regulation of the hypothalamo-hypophyseal system in patients with hypophyseal adenomas]. 61
2587520 1989
47
[FSH, LH, prolactin and testosterone levels in peripheral blood and urinary excretion of 17-ketosteroids and 17-hydroxycorticosteroids in patients after removal of chromophobe adenoma of the pituitary gland]. 61
2641804 1989
48
Dynamic CT scan of intracranial tumors. 61
2512067 1989
49
[A case of pituitary adenoma presenting binasal inferior quadrants hemianopsia]. 61
2615906 1989
50
Post-radiation cranial malignant fibrous histiocytoma studied by CT. 61
2539246 1989

Variations for Chromophobe Adenoma

Expression for Chromophobe Adenoma

Search GEO for disease gene expression data for Chromophobe Adenoma.

Pathways for Chromophobe Adenoma

GO Terms for Chromophobe Adenoma

Cellular components related to Chromophobe Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endosome lumen GO:0031904 8.8 PRLR PRL GH1

Biological processes related to Chromophobe Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to nutrient levels GO:0031667 9.26 PRL GH1
2 lactation GO:0007595 9.16 PRLR PRL
3 positive regulation of JAK-STAT cascade GO:0046427 8.96 PRL GH1
4 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 8.8 PRLR PRL GH1

Molecular functions related to Chromophobe Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 prolactin receptor binding GO:0005148 8.96 PRL GH1
2 hormone activity GO:0005179 8.92 TRH PRL POMC GH1

Sources for Chromophobe Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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