MCID: CHR034
MIFTS: 39

Chromophobe Adenoma

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Chromophobe Adenoma

MalaCards integrated aliases for Chromophobe Adenoma:

Name: Chromophobe Adenoma 12 15
Adenoma, Chromophobe 44 73
Chromophobe Adenoma of the Pituitary Gland 12
Adenoma Chromophobe 55

Classifications:



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Disease Ontology 12 DOID:3828
MeSH 44 D000238
NCIt 50 C2857
SNOMED-CT 68 37039006
UMLS 73 C0001432

Summaries for Chromophobe Adenoma

MalaCards based summary : Chromophobe Adenoma, also known as adenoma, chromophobe, is related to adenoma and conn's syndrome. An important gene associated with Chromophobe Adenoma is PRL (Prolactin), and among its related pathways/superpathways are TGF-Beta Pathway and Peptide ligand-binding receptors. The drugs Hormones and Dexamethasone acetate have been mentioned in the context of this disorder. Affiliated tissues include pituitary, thyroid and ovary, and related phenotypes are endocrine/exocrine gland and liver/biliary system

Related Diseases for Chromophobe Adenoma

Diseases related to Chromophobe Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 107)
# Related Disease Score Top Affiliating Genes
1 adenoma 31.5 GH1 POMC PRL TP53
2 conn's syndrome 30.7 GH1 POMC PRL
3 pituitary tumors 30.5 GH1 POMC PRL
4 galactorrhea 30.3 PRL PRLR
5 hyperthyroidism 30.3 GH1 INS PRL SERPINA7 TRH
6 chiasmal syndrome 30.2 GNRH1 POMC PRL
7 diabetes insipidus 30.2 AVP INS POMC PRL
8 craniopharyngioma 30.1 GH1 GNRH1 INS PRL TRH
9 pituitary apoplexy 30.0 GNRH1 INS POMC PRL
10 hypothyroidism 29.9 GH1 POMC PRL SERPINA7 TRH
11 acromegaly 29.9 GH1 GHRH INS POMC PRL TRH
12 hypopituitarism 29.9 GH1 GHRH GNRH1 INS POMC PRL
13 fibrous dysplasia/mccune-albright syndrome 10.3 GH1 PRL
14 generalized resistance to thyroid hormone 10.3 PRL TRH
15 lymphocytic hypophysitis 10.3 GH1 POMC
16 pituitary carcinoma 10.3 POMC PRL
17 postmenopausal atrophic vaginitis 10.3 POMC PRLR
18 central nervous system germinoma 10.2 AVP POMC
19 hypogonadotropism 10.2 GNRH1 PRL
20 tuberculous epididymitis 10.2 AVP POMC
21 central nervous system germ cell tumor 10.2 AVP POMC
22 lung oat cell carcinoma 10.2 AVP POMC
23 suprasellar meningioma 10.2 POMC TRH
24 bronchus cancer 10.2 AVP POMC
25 nelson syndrome 10.2 POMC PRL
26 inappropriate adh syndrome 10.2 AVP POMC
27 hypoadrenalism 10.2 GH1 POMC
28 pseudohypoparathyroidism, type ia 10.2 GH1 PRL TRH
29 olfactory nerve neoplasm 10.2 AVP POMC
30 pituitary infarct 10.2 GNRH1 POMC PRL
31 scleredema adultorum 10.2 INS POMC
32 acth-secreting pituitary adenoma 10.2 POMC PRL
33 pelvic varices 10.2 GNRH1 PRL
34 adrenal rest tumor 10.2 GNRH1 POMC PRL
35 secondary hypertrophic osteoarthropathy 10.2 AVP POMC
36 secondary adrenal insufficiency 10.2 AVP INS
37 pancreatic endocrine carcinoma 10.2 INS POMC
38 gigantism 10.2 GH1 GHRH PRL
39 sella turcica neoplasm 10.2 GHRH POMC PRL
40 tuberculum sellae meningioma 10.1 GHRH POMC PRL
41 prolactin producing pituitary tumor 10.1 PRL TP53
42 euthyroid sick syndrome 10.1 POMC SERPINA7
43 mucinoses 10.1 INS POMC
44 adenohypophysitis 10.1 GH1 POMC PRL TRH
45 functioning pituitary adenoma 10.1 GH1 POMC PRL TRH
46 pituitary adenoma, prolactin-secreting 10.1 GH1 POMC PRL TRH
47 sheehan syndrome 10.1 INS POMC PRL
48 endocrine organ benign neoplasm 10.1 INS POMC PRL
49 thyroid hormone resistance, generalized, autosomal dominant 10.1 SERPINA7 TRH
50 pituitary hormone deficiency, combined, 2 10.1 AVP GH1 POMC PRL

Graphical network of the top 20 diseases related to Chromophobe Adenoma:



Diseases related to Chromophobe Adenoma

Symptoms & Phenotypes for Chromophobe Adenoma

MGI Mouse Phenotypes related to Chromophobe Adenoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.97 GHRH GNRH1 INS POMC PRL PRLR
2 liver/biliary system MP:0005370 9.8 GHRH GNRH1 INS POMC PRL TET2
3 neoplasm MP:0002006 9.7 FLCN GNRH1 POMC PRL PRLR TET2
4 no phenotypic analysis MP:0003012 9.43 AVP INS POMC TET2 TP53 TRH
5 renal/urinary system MP:0005367 9.17 AVP FLCN GNRH1 INS POMC TET2

Drugs & Therapeutics for Chromophobe Adenoma

Drugs for Chromophobe Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Hormones Phase 2,Phase 1
2
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 1 1177-87-3
3
Dexamethasone Approved, Investigational, Vet_approved Phase 1 50-02-2 5743
4 Antineoplastic Agents, Hormonal Phase 1
5
protease inhibitors Phase 1
6 Peripheral Nervous System Agents Phase 1
7 Anti-Inflammatory Agents Phase 1
8 HIV Protease Inhibitors Phase 1
9 glucocorticoids Phase 1
10 Hormone Antagonists Phase 1
11 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1
12 BB 1101 Phase 1
13 Antiemetics Phase 1
14 Autonomic Agents Phase 1
15 Gastrointestinal Agents Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Temozolomide in Treating Patients With Invasive Pituitary Tumors Withdrawn NCT00601289 Phase 2 temozolomide
2 Gamma-Secretase Inhibitor RO4929097 in Treating Young Patients With Relapsed or Refractory Solid Tumors, CNS Tumors, Lymphoma, or T-Cell Leukemia Terminated NCT01088763 Phase 1 gamma-secretase/Notch signalling pathway inhibitor RO4929097;dexamethasone

Search NIH Clinical Center for Chromophobe Adenoma

Cochrane evidence based reviews: adenoma, chromophobe

Genetic Tests for Chromophobe Adenoma

Anatomical Context for Chromophobe Adenoma

MalaCards organs/tissues related to Chromophobe Adenoma:

41
Pituitary, Thyroid, Ovary, Lung, Breast, Pancreas, Cortex

Publications for Chromophobe Adenoma

Articles related to Chromophobe Adenoma:

(show top 50) (show all 97)
# Title Authors Year
1
An aged bull with concurrent thyroid C cell carcinoma, adrenal pheochromocytoma and pituitary chromophobe adenoma. ( 19262038 )
2009
2
Renal oncocytoma with t(5;12;11), der(1)1;8) and add(19): "true" oncocytoma or chromophobe adenoma? ( 9389566 )
1997
3
Non-functional pituitary chromophobe adenoma in a calf. ( 8878755 )
1996
4
Selective osmoreceptor dysfunction presenting as intermittent hypernatremia following surgery for a pituitary chromophobe adenoma. ( 3728518 )
1986
5
Pituitary Cushing's disease arising from a previously non-functional corticotrophic chromophobe adenoma. ( 2985300 )
1985
6
Spontaneous hemorrhagic necrosis of chromophobe adenoma with clinical presentations simulating rupture of aneurysm. ( 7077217 )
1982
7
Collection of gas within a huge chromophobe adenoma. A case report. ( 7121823 )
1982
8
Squamous metaplasia following necrosis of the adenohypophysis and of a chromophobe adenoma of the pituitary. ( 7080436 )
1982
9
Hypothyroidism secondary to biologically inactive thyroid-stimulating hormone secretion by a pituitary chromophobe adenoma: recovery after removal of the tumor. ( 7103637 )
1982
10
Chromophobe adenoma of the pituitary with Cushing's syndrome and skin pigmentation. ( 514937 )
1979
11
Multiple myeloma masquerading as chromophobe adenoma. ( 445346 )
1979
12
Variations in LH and FSH serum gonadotropins in the hypophyseal chromophobe adenoma and acromegaly in the woman in relation to age. ( 675127 )
1978
13
Cytoplasmic filamentous masses in chromophobe adenoma of the human pituitary gland. ( 722396 )
1978
14
Ultrastructure of capillaries in chromophobe adenoma. ( 714208 )
1978
15
Malignant pituitary chromophobe adenoma in an infant accompanying diabetes insipidus. ( 735828 )
1978
16
An unusual case of chromophobe adenoma with conspicuous calcifications. ( 920311 )
1977
17
Ultrastructure of chromophobe adenoma of the human pituitary gland. ( 915598 )
1977
18
An autopsy case of pituitary chromophobe adenoma. ( 614080 )
1977
19
Case report. Tandem lesions: chromophobe adenoma and meningioma. ( 615235 )
1977
20
Galactorrhea in a 12-year-old boy with a chromophobe adenoma. ( 558298 )
1977
21
Chromophobe adenoma and chiasmal syndrome without enlargement of the bony sella. ( 970854 )
1976
22
Pathophysiological and pathogenic interpretation of the clinical picture of chromophobe adenoma of the hypophysis and of craniopharyngioma. ( 1053393 )
1976
23
Calcification in a chromophobe adenoma. Case report. ( 1262925 )
1976
24
Chromophobe adenoma manifesting as a nasopharyngeal mass. ( 971137 )
1976
25
Nasal obstruction caused by a pituitary chromophobe adenoma. ( 979497 )
1976
26
Case of hyperthyroidism due to a chromophobe adenoma. ( 1269160 )
1976
27
The fine structure of a prolactin-rich pituitary chromophobe adenoma (a case report). ( 977384 )
1976
28
Third ventricular chromophobe adenoma with normal adenohypophysis. ( 961385 )
1976
29
McCune-Albright syndrome associated with a functioning pituitary chromophobe adenoma. ( 932906 )
1976
30
The diagnostic problem of multiple intracranial tumours--case report of a pituitary chromophobe adenoma and cerebellar haemangioblastoma. ( 1240630 )
1975
31
The role of visual fields and visual acuity in the treatment of chromophobe adenoma of the pituitary gland. A case report. ( 4423942 )
1974
32
Effects of surgical treatment on hypothalamo-pituitary-adrenocortical functions in pituitary chromophobe adenoma and craniopharyngioma. ( 4548402 )
1974
33
Case report: spontaneous intracranial "aerocoele" with chromophobe adenoma. ( 4433985 )
1974
34
Chromophobe adenoma presenting with a hemianopic temporal arcuate scotoma. ( 4813313 )
1974
35
Familial polyposis and pituitary chromophobe adenoma. ( 4528562 )
1974
36
Chromophobe adenoma masquerading as corticosteroid-responsive optic neuritis. ( 4369864 )
1974
37
Chromophobe adenoma of the pituitary gland masquerading as bilateral nasal polypi--report of a case. ( 4818288 )
1974
38
Pituitary chromophobe adenoma in a cat. ( 4779122 )
1973
39
Laser perimetry: diagnostic application in six cases of pituitary chromophobe adenoma. ( 4801814 )
1973
40
Chromophobe adenoma of pituitary with acromegaly and acoustic neurinoma occurring in the same patient. A case report and review of the literature. ( 4539438 )
1973
41
Chromophobe adenoma of pituitary--the silent lesion. A case report. ( 4540952 )
1973
42
Fulminant meningitis associated with asymptomatic chromophobe adenoma. ( 5017859 )
1972
43
The fine structure of blood vessels in chromophobe adenoma. ( 4673965 )
1972
44
Metastasis of mammary carcinoma in a chromophobe adenoma of the hypophysis. ( 5138127 )
1971
45
Asymptomatic chromophobe adenoma in an eight-year-old child biopsied by stereotaxic technique and treated with cobalt-60. Case report. ( 4908799 )
1970
46
Chromophobe adenoma in a dog. ( 5202559 )
1970
47
Hyperthyroidism due to thyrotropin-producing pituitary chromophobe adenoma. ( 5470849 )
1970
48
Aldosterone secretion and plasma renin activity in chromophobe adenoma: effect of acth. ( 4320036 )
1970
49
Pituitary apoplexy in a woman with chromophobe adenoma. ( 5803519 )
1969
50
Chromophobe adenoma of the pituitary in a dog. ( 5815850 )
1969

Variations for Chromophobe Adenoma

Expression for Chromophobe Adenoma

Search GEO for disease gene expression data for Chromophobe Adenoma.

Pathways for Chromophobe Adenoma

Pathways related to Chromophobe Adenoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.21 GH1 GHRH GNRH1 INS PRL PRLR
2
Show member pathways
13.03 AVP GH1 GHRH GNRH1 POMC PRL
3
Show member pathways
12.64 GH1 INS PRL PRLR TP53
4
Show member pathways
12.07 GH1 INS PRL PRLR
5
Show member pathways
11.88 GH1 GHRH GNRH1 TP53
6 11.82 AVP GHRH POMC
7 11.75 GH1 INS PRLR
8 11.35 POMC PRL TP53
9 10.83 INS PRL PRLR
10
Show member pathways
10.41 GH1 PRL PRLR

GO Terms for Chromophobe Adenoma

Cellular components related to Chromophobe Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.86 AVP GH1 GHRH GNRH1 INS POMC
2 extracellular region GO:0005576 9.65 AVP GH1 GHRH GNRH1 INS POMC
3 secretory granule GO:0030141 9.46 AVP POMC PRL TRH
4 endosome lumen GO:0031904 8.92 GH1 INS PRL PRLR

Biological processes related to Chromophobe Adenoma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor signaling pathway GO:0007186 9.95 AVP GHRH GNRH1 INS POMC TRH
2 response to ethanol GO:0045471 9.62 AVP GNRH1 PRL TRH
3 response to organic cyclic compound GO:0014070 9.55 AVP GNRH1 PRL TET2 TRH
4 positive regulation of JAK-STAT cascade GO:0046427 9.49 GH1 PRL
5 positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 9.46 GH1 GHRH
6 ovulation cycle GO:0042698 9.43 GNRH1 PRL
7 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 9.43 GH1 PRL PRLR
8 cell-cell signaling GO:0007267 9.43 AVP GHRH GNRH1 INS POMC TRH
9 negative regulation of feeding behavior GO:2000252 9.4 INS TRH
10 positive regulation of lactation GO:1903489 9.37 GHRH PRL
11 regulation of signaling receptor activity GO:0010469 9.23 AVP GH1 GHRH GNRH1 INS POMC

Molecular functions related to Chromophobe Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.23 AVP GH1 GHRH GNRH1 INS POMC
2 basic amino acid transmembrane transporter activity GO:0015174 9.16 SLC7A3 SLC7A4
3 prolactin receptor binding GO:0005148 8.96 GH1 PRL

Sources for Chromophobe Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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