CRCC
MCID: CHR177
MIFTS: 58

Chromophobe Renal Cell Carcinoma (CRCC)

Categories: Cancer diseases, Nephrological diseases, Rare diseases

Aliases & Classifications for Chromophobe Renal Cell Carcinoma

MalaCards integrated aliases for Chromophobe Renal Cell Carcinoma:

Name: Chromophobe Renal Cell Carcinoma 12 53 59 6 15 17 72
Renal Cell Carcinoma, Chromophobe Cell 12
Chromophobe Renal Cell Adenocarcinoma 59
Chromophobe Carcinoma of Kidney 12
Chromophobe Renal Carcinoma 75
Chromophobe Adenocarcinoma 12
Chromophobe Carcinoma 72
Kidney Chromophobe 12
Chrcc 53
Crcc 53

Classifications:

Orphanet: 59  
Rare renal diseases


External Ids:

Disease Ontology 12 DOID:4471
MeSH 44 D002292
NCIt 50 C4146
ICD10 via Orphanet 34 C64
UMLS via Orphanet 73 C1266042
Orphanet 59 ORPHA319303
UMLS 72 C1266042 C3887514

Summaries for Chromophobe Renal Cell Carcinoma

NIH Rare Diseases : 53 Chromophobe renal cell carcinoma is a rare subtype of the most common form of kidney cancer called renal cell carcinoma (RCC). This type of cancer forms in the cells lining the small tubules in the kidney. These tubules help filter waste from the blood, making urine. Chromophobe RCC accounts for about 5% of all RCC cases, and it is frequently diagnosed between ages 40 and 50. It is typically diagnosed in stage I or stage II, and has an overall better prognosis than other types of RCC. Treatment generally involves surgery.

MalaCards based summary : Chromophobe Renal Cell Carcinoma, also known as renal cell carcinoma, chromophobe cell, is related to renal cell carcinoma, nonpapillary and renal oncocytoma, and has symptoms including flank pain An important gene associated with Chromophobe Renal Cell Carcinoma is FLCN (Folliculin), and among its related pathways/superpathways are Cell cycle Cell cycle (generic schema) and WNT Signaling. The drugs Sorafenib and Bevacizumab have been mentioned in the context of this disorder. Affiliated tissues include kidney, brain and breast, and related phenotypes are liver/biliary system and renal/urinary system

Disease Ontology : 12 A renal cell carcinoma that has material basis in chromophobe cell that appear pale when viewed under microscope, but that are larger and display different features than clear cells.

Wikipedia : 75 Renal cell carcinoma (RCC) is a kidney cancer that originates in the lining of the proximal convoluted... more...

Related Diseases for Chromophobe Renal Cell Carcinoma

Diseases related to Chromophobe Renal Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 157)
# Related Disease Score Top Affiliating Genes
1 renal cell carcinoma, nonpapillary 31.9 S100A1 MME KRT8 KRT7 KIT HNF1B
2 renal oncocytoma 31.5 MME KRT7 KIT FLCN CLDN8 CDH16
3 collecting duct carcinoma 31.4 PBRM1 MME KRT7
4 renal cell carcinoma, papillary, 1 31.3 MME KRT7 KIT CDH16
5 clear cell renal cell carcinoma 31.2 PBRM1 MME KRT7 HNF1A FLCN CDH16
6 seminal vesicle tumor 30.8 KRT7 KRT18
7 oncocytoma 30.7 MME KRT8 KRT7 KRT18 KIT FLCN
8 adenoid cystic carcinoma 30.4 S100A1 KRT7 KIT CCND1
9 eosinophilic variant of chromophobe renal cell carcinoma 12.7
10 classic variant of chromophobe renal cell carcinoma 12.5
11 birt-hogg-dube syndrome 11.8
12 renal cell carcinoma, xp11-associated 11.5
13 krukenberg carcinoma 10.8 KRT7 HNF1B
14 ceruminoma 10.8 KRT7 KIT
15 jejunal cancer 10.8 KRT7 KIT
16 intratubular embryonal carcinoma 10.7 KRT7 KIT
17 balloon cell malignant melanoma 10.7 MME KRT7
18 cervical adenoma malignum 10.7 MME KRT7
19 cribriform carcinoma 10.7 KRT7 KIT
20 adenoid basal cell carcinoma 10.7 KRT7 KIT
21 cervical mucinous adenocarcinoma 10.7 MME KRT7
22 maturity-onset diabetes of the young, type 4 10.7 HNF1B HNF1A
23 malignant iris melanoma 10.7 S100A1 CCND1
24 benign breast phyllodes tumor 10.6 MME KIT
25 polycystic liver disease 1 with or without kidney cysts 10.6 KRT7 HNF1B FLCN
26 gallbladder sarcoma 10.6 KRT18 KIT
27 epithelioid trophoblastic tumor 10.6 KRT7 KRT18
28 maturity-onset diabetes of the young, type 2 10.6 HNF1B HNF1A
29 endolymphatic sac tumor 10.6 KRT8 KRT7
30 adenomyoma 10.6 MME KRT7
31 cavernous hemangioma 10.6 S100A1 KRT7 KIT
32 malignant leydig cell tumor 10.6 MME KRT7 KIT
33 lymphoepithelioma-like thymic carcinoma 10.6 KRT18 KIT
34 bladder lymphoma 10.6 MME KRT7
35 kidney cancer 10.6
36 hidrocystoma 10.6 KRT8 KRT7
37 mixed cell type cancer 10.6 MME KRT7 KIT
38 adenoid squamous cell carcinoma 10.6 KRT8 KRT7
39 jejunal adenocarcinoma 10.5 KRT7 CCND1
40 carcinosarcoma 10.5 MME KRT7 KIT
41 apocrine sweat gland neoplasm 10.5 KRT8 KRT7
42 neurenteric cyst 10.5 KRT8 KRT18
43 warthin tumor 10.5 KRT7 KRT18 KIT
44 nasal cavity cancer 10.5 KRT8 KRT7
45 cystic nephroma 10.5 MME KIT
46 oropharynx cancer 10.5 KRT7 KIT CCND1
47 leiomyoma 10.5 S100A1 MME KIT
48 ovarian lymphoma 10.5 MME KRT18
49 chromophil renal cell carcinoma 10.5
50 rete testis adenocarcinoma 10.5 MME KIT

Graphical network of the top 20 diseases related to Chromophobe Renal Cell Carcinoma:



Diseases related to Chromophobe Renal Cell Carcinoma

Symptoms & Phenotypes for Chromophobe Renal Cell Carcinoma

UMLS symptoms related to Chromophobe Renal Cell Carcinoma:


flank pain

MGI Mouse Phenotypes related to Chromophobe Renal Cell Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 liver/biliary system MP:0005370 9.5 HNF1A HNF1B KIT KRT18 KRT8 MME
2 renal/urinary system MP:0005367 9.17 CLDN8 FLCN FOXI1 HNF1A HNF1B KIT

Drugs & Therapeutics for Chromophobe Renal Cell Carcinoma

Drugs for Chromophobe Renal Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sorafenib Approved, Investigational Phase 1, Phase 2 284461-73-0 216239 406563
2
Bevacizumab Approved, Investigational Phase 1, Phase 2 216974-75-3
3 Angiogenesis Inhibitors Phase 1, Phase 2
4 Angiogenesis Modulating Agents Phase 1, Phase 2
5 Protein Kinase Inhibitors Phase 1, Phase 2
6 Antineoplastic Agents, Immunological Phase 1, Phase 2
7 Antibodies
8 Immunoglobulins

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase I/II Trial of BAY 43-9006 in Combination With Bevacizumab in Patients With Advanced Renal Cancer Completed NCT00126503 Phase 1, Phase 2 Sorafenib Tosylate
2 A Phase 1 Study Evaluating the Safety, Pharmacokinetics and Anti-Tumor Activity of ABBV-176 in Subjects With Advanced Solid Tumors Likely to Express Prolactin Receptor (PRLR) Terminated NCT03145909 Phase 1 ABBV-176
3 Clinical Manifestations and Molecular Bases of Heritable Urologic Malignant Disorders Recruiting NCT00001238
4 Aerobic Exercise and Cognitive Functioning in Women With Breast Cancer: the ACTIVATE Trial Recruiting NCT03277898
5 Study of the Impact of VEGF Polymorphism on the Development of Renal Carcinoma in Renal Transplant Patients Recruiting NCT03114826
6 Role of Immunohistochemical Markers , Geminin and Mcm2 in Prognosis of Renal Cell Carcinoma, and Its Clinicopathological Correlation. A Prospective Controlled Study Not yet recruiting NCT03692533

Search NIH Clinical Center for Chromophobe Renal Cell Carcinoma

Genetic Tests for Chromophobe Renal Cell Carcinoma

Anatomical Context for Chromophobe Renal Cell Carcinoma

MalaCards organs/tissues related to Chromophobe Renal Cell Carcinoma:

41
Kidney, Brain, Breast, Liver, Smooth Muscle, Thyroid, Myeloid

Publications for Chromophobe Renal Cell Carcinoma

Articles related to Chromophobe Renal Cell Carcinoma:

(show top 50) (show all 545)
# Title Authors PMID Year
1
Germline hepatocyte nuclear factor 1alpha and 1beta mutations in renal cell carcinomas. 38 71
15649945 2005
2
The folliculin mutation database: an online database of mutations associated with Birt-Hogg-Dubé syndrome. 71
19562744 2009
3
Clinical and genetic studies of Birt-Hogg-Dubé syndrome. 71
12471204 2002
4
Mutation screening in 18 Caucasian families suggest the existence of other MODY genes. 71
9754819 1998
5
Allele Loss and Reduced Expression of CYCLOPS Genes is a Characteristic Feature of Chromophobe Renal Cell Carcinoma. 38
31200327 2019
6
An Epithelioid Smooth Muscle Neoplasm Mimicking a Signet Ring Cell Carcinoma in the Ovary. 38
29750703 2019
7
Eosinophilic Kidney Tumors: Old and New. 38
31403331 2019
8
Sporadic renal hybrid oncocytic/chromophobe tumor in a young man: A case report. 38
31415358 2019
9
Sarcomatoid Chromophobe Renal Cell Carcinoma: A Case Report and Review of the Literature. 38
31423007 2019
10
Identification of CFTR as a novel key gene in chromophobe renal cell carcinoma through bioinformatics analysis. 38
31423244 2019
11
Palliative TACE for hepatic metastases of chromophobe renal cell carcinoma. 38
31308185 2019
12
Robot-assisted partial nephrectomy with a standard laparoscopic ultrasound probe in treating endophytic renal tumor. 38
31350090 2019
13
Recent advances in the systemic treatment of metastatic non-clear cell renal cell carcinomas. 38
31183903 2019
14
FOXI1 Immunohistochemistry Differentiates Benign Renal Oncocytoma from Malignant Chromophobe Renal Cell Carcinoma. 38
31177114 2019
15
Hybrid oncocytic/chromophobe renal tumors are molecularly distinct from oncocytoma and chromophobe renal cell carcinoma. 38
31231128 2019
16
Chromophobe Renal Cell Carcinoma: Results From a Large Single-Institution Series. 38
31326335 2019
17
Clinicopathological and survival analysis of clinically advanced papillary and chromophobe renal cell carcinoma. 38
31174958 2019
18
Metastatic Chromophobe Renal Cell Carcinoma: Presence or Absence of Sarcomatoid Differentiation Determines Clinical Course and Treatment Outcomes. 38
31036466 2019
19
Chromophobe Renal Cell Carcinoma Presenting as a Cystic Renal Mass: Case Report and Review of the Literature. 38
31040264 2019
20
Utility of cytokeratin 7, S100A1 and caveolin-1 as immunohistochemical biomarkers to differentiate chromophobe renal cell carcinoma from renal oncocytoma. 38
31236330 2019
21
Peritumoral pseudocapsule status according to pathological characteristics from robot-assisted laparoscopic partial nephrectomy for localized renal cell carcinoma. 38
30650470 2019
22
Clinicopathologic and Genomic Factors Associated With Oncologic Outcome in Patients With Stage III to IV Chromophobe Renal Cell Carcinoma. 38
30639042 2019
23
Immunostaining characteristics of irisin in benign and malignant renal cancers. 38
30896263 2019
24
Using Aorta-Lesion-Attenuation Difference on Preoperative Contrast-enhanced Computed Tomography Scan to Differentiate Between Malignant and Benign Renal Tumors. 38
30552939 2019
25
Chromophobe renal cell carcinoma or oncocytoma: a manner of challenge in frozen section diagnosis. 38
30794153 2019
26
A rare case of tumor-to-tumor metastasis: Prostate cancer to chromophobe renal cell carcinoma. 38
30505689 2019
27
Papillary Adenomas and Other Small Epithelial Tumors in the Kidney: An Autopsy Study. 38
30418186 2019
28
Compare Fuhrman Nuclear and Chromophobe Tumor Grade on Chromophobe RCC. 38
31032425 2019
29
The history of urologic pathology: an overview. 38
30565309 2019
30
A Case of Stage IV Chromophobe Renal Cell Carcinoma Treated with the Oncolytic ECHO-7 Virus, Rigvir®. 38
30635548 2019
31
Intense Choline Activity in Renal Cell Carcinoma Without Obvious 18F-FDG Uptake. 38
30371589 2019
32
Metachronous isolated locally advanced pancreatic metastasis from chromophobe renal cell carcinoma. 38
31233964 2019
33
Discrimination of oncocytoma and chromophobe renal cell carcinoma using MRI. 38
30644365 2019
34
[Pigmented microcystic chromophobe renal cell carcinoma: a clinicopathologic analysis of five cases]. 38
30522173 2018
35
"High-grade oncocytic renal tumor": morphologic, immunohistochemical, and molecular genetic study of 14 cases. 38
30232607 2018
36
Hybrid oncocytic/chromophobe renal cell tumor: An integrated genetic and epigenetic characterization of a case. 38
30343009 2018
37
[Correlation studies of distinct mutational signatures with common cancer pathological subtyping]. 38
30465536 2018
38
Kidney Carcinoma Ovarian Metastasis: Review of the Literature. 38
30693167 2018
39
Caspase 3 as a Novel Marker to Distinguish Chromophobe Renal Cell Carcinoma from Oncocytoma. 38
30467700 2018
40
Pathologically examining a minimum of three lymph nodes could better determine node negativity in patients with non-metastatic chromophobe renal cell carcinoma. 38
30137442 2018
41
Chromophobe Renal Cell Carcinoma With Retrograde Venous Invasion and Gain of Chromosome 21: Potential Harbingers of Aggressive Clinical Behavior. 38
29560759 2018
42
Chromophobe renal cell carcinoma with sarcomatoid differentiation containing various heterologous components. 38
30015409 2018
43
Localized chromophobe renal cell carcinoma: preoperative imaging judgment and laparoscopic simple enucleation for treatment. 38
29757571 2018
44
Cytogenetic and immunohistochemical study of 42 pigmented microcystic chromophobe renal cell carcinoma (PMChRCC). 38
29931469 2018
45
Leptin and its receptor: can they help to differentiate chromophobe renal cell carcinoma from renal oncocytoma? 38
29970253 2018
46
Identification and Validation of Radiographic Enhancement for Reliable Differentiation of CD117(+) Benign Renal Oncocytoma and Chromophobe Renal Cell Carcinoma. 38
29752278 2018
47
An Easy and Effective Method to Locate Renal Vein During Retroperitoneal Laparoscopic Radical Nephrectomy: Single-Center Experience. 38
30040793 2018
48
Oncocytoma managed by active surveillance in a transplant allograft kidney: a case report. 38
29966524 2018
49
Impairment of gamma-glutamyl transferase 1 activity in the metabolic pathogenesis of chromophobe renal cell carcinoma. 38
29891694 2018
50
Variation in nuclear size and PD-L2 positivity correlate with aggressive chromophobe renal cell carcinoma. 38
29661724 2018

Variations for Chromophobe Renal Cell Carcinoma

ClinVar genetic disease variations for Chromophobe Renal Cell Carcinoma:

6
# Gene Variation Type Significance SNP ID GRCh37 Pos GRCh38 Pos
1 FLCN FLCN, 2-BP DEL, 1284TC AND 2-BP INS, 1284AC indel Pathogenic
2 HNF1B NM_000458.4(HNF1B): c.46del (p.Leu16fs) deletion Pathogenic rs587776771 17:36104830-36104830 17:37744839-37744839
3 HNF1A NM_000545.6(HNF1A): c.92G> A (p.Gly31Asp) single nucleotide variant Uncertain significance rs137853247 12:121416663-121416663 12:120978860-120978860

Cosmic variations for Chromophobe Renal Cell Carcinoma:

9 (show top 50) (show all 2287)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM249350 ZNF804A kidney,NS,carcinoma,clear cell renal cell carcinoma c.2363A>C p.Q788P 2:184937759-184937759 12
2 COSM249389 ZNF804A kidney,NS,carcinoma,clear cell renal cell carcinoma c.121G>C p.E41Q 2:184866378-184866378 12
3 COSM249348 ZNF800 kidney,NS,carcinoma,clear cell renal cell carcinoma c.719A>G p.N240S 7:127374617-127374617 12
4 COSM249454 ZNF521 kidney,NS,carcinoma,clear cell renal cell carcinoma c.3298A>G p.S1100G 18:25224620-25224620 12
5 COSM30510 ZNF423 kidney,NS,carcinoma,clear cell renal cell carcinoma c.3559G>A p.V1187I 16:49626188-49626188 12
6 COSM6970086 ZFHX3 kidney,NS,carcinoma,clear cell renal cell carcinoma c.7052G>A p.C2351Y 16:72795630-72795630 12
7 COSM6940591 ZFHX3 kidney,NS,carcinoma,chromophobe renal cell carcinoma c.4509G>T p.Q1503H 16:72798173-72798173 12
8 COSM3276983 ZFHX3 kidney,NS,carcinoma,clear cell renal cell carcinoma c.745G>A p.G249S 16:72959401-72959401 12
9 COSM6961023 YES1 kidney,NS,carcinoma,clear cell renal cell carcinoma c.1069T>A p.L357I 18:739803-739803 12
10 COSM6935891 YAP1 kidney,NS,carcinoma,clear cell renal cell carcinoma c.374C>G p.A125G 11:102114196-102114196 12
11 COSM6946890 XIAP kidney,NS,carcinoma,clear cell renal cell carcinoma c.1001A>T p.K334M 23:123891261-123891261 12
12 COSM6941466 XIAP kidney,NS,carcinoma,renal cell carcinoma unclassified c.563G>C p.G188A 23:123886225-123886225 12
13 COSM249421 WWP2 kidney,NS,carcinoma,clear cell renal cell carcinoma c.2056G>C p.E686Q 16:69936391-69936391 12
14 COSM1272065 WT1 kidney,NS,carcinoma,clear cell renal cell carcinoma c.332C>A p.P111H 11:32434810-32434810 12
15 COSM6201648 WT1 kidney,NS,carcinoma,clear cell renal cell carcinoma c.1228+1G>C p.? 11:32391971-32391971 12
16 COSM20759 WNK3 kidney,NS,carcinoma,clear cell renal cell carcinoma c.3809C>A p.T1270N 23:54238942-54238942 12
17 COSM249519 VWA8 kidney,NS,carcinoma,clear cell renal cell carcinoma c.3300A>T p.E1100D 13:41701456-41701456 12
18 COSM249385 VWA8 kidney,NS,carcinoma,clear cell renal cell carcinoma c.1286A>G p.Q429R 13:41865963-41865963 12
19 COSM6930635 VTCN1 kidney,NS,carcinoma,clear cell renal cell carcinoma c.98-1G>T p.? 1:117156922-117156922 12
20 COSM26611 VPS13B kidney,NS,carcinoma,clear cell renal cell carcinoma c.2580C>T p.Y860Y 8:99274262-99274262 12
21 COSM14311 VHL kidney,NS,carcinoma,clear cell renal cell carcinoma c.499C>T p.R167W 3:10149822-10149822 12
22 COSM14312 VHL kidney,NS,carcinoma,renal cell carcinoma unclassified c.353T>C p.L118P 3:10146526-10146526 12
23 COSM14375 VHL kidney,NS,carcinoma,clear cell renal cell carcinoma c.343C>T p.H115Y 3:10146516-10146516 12
24 COSM17715 VHL kidney,NS,carcinoma,clear cell renal cell carcinoma c.221T>A p.V74D 3:10142068-10142068 12
25 COSM17855 VHL kidney,NS,carcinoma,clear cell renal cell carcinoma c.233A>G p.N78S 3:10142080-10142080 12
26 COSM18024 VHL kidney,NS,carcinoma,clear cell renal cell carcinoma c.598C>T p.R200W 3:10149921-10149921 12
27 COSM18074 VHL kidney,NS,carcinoma,clear cell renal cell carcinoma c.193T>C p.S65P 3:10142040-10142040 12
28 COSM18152 VHL kidney,NS,carcinoma,clear cell renal cell carcinoma c.463G>A p.V155M 3:10146636-10146636 12
29 COSM30224 VHL kidney,NS,carcinoma,clear cell renal cell carcinoma c.326T>G p.I109S 3:10142173-10142173 12
30 COSM14318 VHL kidney,NS,carcinoma,clear cell renal cell carcinoma c.231C>A p.C77* 3:10142078-10142078 12
31 COSM14373 VHL kidney,NS,carcinoma,clear cell renal cell carcinoma c.400G>T p.E134* 3:10146573-10146573 12
32 COSM14389 VHL kidney,NS,carcinoma,clear cell renal cell carcinoma c.452T>G p.I151S 3:10146625-10146625 12
33 COSM97151 VHL kidney,NS,carcinoma,clear cell renal cell carcinoma c.477A>T p.K159N 3:10149800-10149800 12
34 COSM1417312 VHL kidney,NS,carcinoma,clear cell renal cell carcinoma c.424G>A p.V142I 3:10146597-10146597 12
35 COSM14400 VHL kidney,NS,carcinoma,clear cell renal cell carcinoma c.194C>T p.S65L 3:10142041-10142041 12
36 COSM17657 VHL kidney,NS,carcinoma,clear cell renal cell carcinoma c.472C>G p.L158V 3:10149795-10149795 12
37 COSM17909 VHL kidney,NS,carcinoma,clear cell renal cell carcinoma c.482G>C p.R161P 3:10149805-10149805 12
38 COSM18350 VHL kidney,NS,carcinoma,clear cell renal cell carcinoma c.256C>T p.P86S 3:10142103-10142103 12
39 COSM14290 VHL kidney,NS,carcinoma,clear cell renal cell carcinoma c.240T>A p.S80R 3:10142087-10142087 12
40 COSM14407 VHL kidney,NS,carcinoma,clear cell renal cell carcinoma c.388G>C p.V130L 3:10146561-10146561 12
41 COSM18005 VHL kidney,NS,carcinoma,clear cell renal cell carcinoma c.340+1G>A p.? 3:10142188-10142188 12
42 COSM18353 VHL kidney,NS,carcinoma,clear cell renal cell carcinoma c.331A>G p.S111G 3:10142178-10142178 12
43 COSM18355 VHL kidney,NS,carcinoma,clear cell renal cell carcinoma c.453C>G p.I151M 3:10146626-10146626 12
44 COSM14346 VHL kidney,NS,carcinoma,clear cell renal cell carcinoma c.266T>C p.L89P 3:10142113-10142113 12
45 COSM14380 VHL kidney,NS,carcinoma,renal cell carcinoma unclassified c.548C>A p.S183* 3:10149871-10149871 12
46 COSM18015 VHL kidney,NS,carcinoma,clear cell renal cell carcinoma c.194C>A p.S65* 3:10142041-10142041 12
47 COSM97142 VHL kidney,NS,carcinoma,clear cell renal cell carcinoma c.264G>T p.W88C 3:10142111-10142111 12
48 COSM97146 VHL kidney,NS,carcinoma,clear cell renal cell carcinoma c.357C>A p.F119L 3:10146530-10146530 12
49 COSM14363 VHL kidney,NS,carcinoma,clear cell renal cell carcinoma c.458T>C p.L153P 3:10146631-10146631 12
50 COSM17731 VHL kidney,NS,carcinoma,clear cell renal cell carcinoma c.288G>T p.Q96H 3:10142135-10142135 12

Expression for Chromophobe Renal Cell Carcinoma

LifeMap Discovery
Genes differentially expressed in tissues of Chromophobe Renal Cell Carcinoma patients vs. healthy controls: 35 (show top 50) (show all 297)
# Gene Description Tissue Up/Dn Fold Change (log2) P value
1 SLC12A1 solute carrier family 12 (sodium/potassium/chloride transporter), member 1 Kidney - 10.96 0.000
2 NAT8 N-acetyltransferase 8 (GCN5-related, putative) Kidney - 9.85 0.000
3 CALB1 calbindin 1, 28kDa Kidney - 9.44 0.000
4 GLYAT glycine-N-acyltransferase Kidney - 9.24 0.000
5 KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16 Kidney - 9.21 0.000
6 FABP1 fatty acid binding protein 1, liver Kidney - 8.95 0.000
7 MIOX myo-inositol oxygenase Kidney - 8.89 0.000
8 PLG plasminogen Kidney - 8.67 0.000
9 NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin) Kidney - 8.34 0.000
10 CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) Kidney + 8.22 0.000
11 G6PC glucose-6-phosphatase, catalytic subunit Kidney - 8.14 0.000
12 SLC16A9 solute carrier family 16, member 9 Kidney - 8.05 0.000
13 ACMSD aminocarboxymuconate semialdehyde decarboxylase Kidney - 8.04 0.000
14 ALDOB aldolase B, fructose-bisphosphate Kidney - 8.03 0.000
15 GSTA1 glutathione S-transferase alpha 1 Kidney - 8.01 0.000
16 SCNN1G sodium channel, non voltage gated 1 gamma subunit Kidney - 7.85 0.000
17 HS6ST2 heparan sulfate 6-O-sulfotransferase 2 Kidney - 7.84 0.000
18 PDZK1IP1 PDZK1 interacting protein 1 Kidney - 7.83 0.000
19 TSPAN8 tetraspanin 8 Kidney - 7.82 0.000
20 BHMT betaine--homocysteine S-methyltransferase Kidney - 7.75 0.000
21 FMO1 flavin containing monooxygenase 1 Kidney - 7.57 0.000
22 BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 Kidney - 7.57 0.000
23 DZIP1 DAZ interacting zinc finger protein 1 Kidney - 7.56 0.000
24 RNF128 ring finger protein 128, E3 ubiquitin protein ligase Kidney - 7.53 0.000
25 ANPEP alanyl (membrane) aminopeptidase Kidney - 7.51 0.000
26 MUC15 mucin 15, cell surface associated Kidney - 7.45 0.000
27 AGXT2 alanine--glyoxylate aminotransferase 2 Kidney - 7.43 0.000
28 ALDH8A1 aldehyde dehydrogenase 8 family, member A1 Kidney - 7.36 0.000
29 SOSTDC1 sclerostin domain containing 1 Kidney - 7.31 0.000
30 SLC7A13 solute carrier family 7 (anionic amino acid transporter), member 13 Kidney - 7.31 0.000
31 FAM151A family with sequence similarity 151, member A Kidney - 7.26 0.000
32 TOX thymocyte selection-associated high mobility group box Kidney - 7.23 0.000
33 SLC22A8 solute carrier family 22 (organic anion transporter), member 8 Kidney - 7.20 0.000
34 DHRS2 dehydrogenase/reductase (SDR family) member 2 Kidney + 7.18 0.000
35 UGT2A3 UDP glucuronosyltransferase 2 family, polypeptide A3 Kidney - 7.13 0.002
36 TYRP1 tyrosinase-related protein 1 Kidney - 7.11 0.000
37 GPC5 glypican 5 Kidney - 7.10 0.000
38 PDZK1 PDZ domain containing 1 Kidney - 7.09 0.002
39 KRT19 keratin 19, type I Kidney - 7.03 0.000
40 FGFR3 fibroblast growth factor receptor 3 Kidney - 7.02 0.000
41 CLIC5 chloride intracellular channel 5 Kidney - 7.02 0.001
42 SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13 Kidney - 6.97 0.000
43 CYP4A11 cytochrome P450, family 4, subfamily A, polypeptide 11 Kidney - 6.90 0.000
44 CYP4A22 cytochrome P450, family 4, subfamily A, polypeptide 22 Kidney - 6.89 0.000
45 SLC22A2 solute carrier family 22 (organic cation transporter), member 2 Kidney - 6.89 0.000
46 GLYATL1 glycine-N-acyltransferase-like 1 Kidney - 6.89 0.000
47 GBA3 glucosidase, beta, acid 3 (gene/pseudogene) Kidney - 6.88 0.000
48 UPB1 ureidopropionase, beta Kidney - 6.88 0.000
49 LUM lumican Kidney - 6.88 0.000
50 NTRK2 neurotrophic tyrosine kinase, receptor, type 2 Kidney - 6.82 0.000
Search GEO for disease gene expression data for Chromophobe Renal Cell Carcinoma.

Pathways for Chromophobe Renal Cell Carcinoma

Pathways related to Chromophobe Renal Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.39 HNF1B HNF1A CDH16 CCND1
2 11.32 HNF1B HNF1A CDH16 CCND1
3
Show member pathways
11.17 KRT8 KRT7 KRT18

GO Terms for Chromophobe Renal Cell Carcinoma

Cellular components related to Chromophobe Renal Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apicolateral plasma membrane GO:0016327 8.96 KRT8 CLDN8
2 keratin filament GO:0045095 8.8 KRT8 KRT7 KRT18

Biological processes related to Chromophobe Renal Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cornification GO:0070268 9.54 KRT8 KRT7 KRT18
2 liver development GO:0001889 9.43 HNF1B HNF1A CCND1
3 epithelial cell proliferation GO:0050673 9.32 KIT HNF1B
4 hepatocyte apoptotic process GO:0097284 9.16 KRT8 KRT18
5 positive regulation of transcription initiation from RNA polymerase II promoter GO:0060261 8.96 HNF1B HNF1A
6 regulation of pronephros size GO:0035565 8.62 HNF1B HNF1A

Molecular functions related to Chromophobe Renal Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein-containing complex binding GO:0044877 9.26 KRT8 HNF1B FLCN CCND1
2 structural molecule activity GO:0005198 8.62 KRT18 CLDN8

Sources for Chromophobe Renal Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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