SCLL
MCID: CHR375
MIFTS: 28

Chromosome 8p11 Myeloproliferative Syndrome (SCLL)

Categories: Blood diseases, Cancer diseases, Immune diseases, Rare diseases

Aliases & Classifications for Chromosome 8p11 Myeloproliferative Syndrome

MalaCards integrated aliases for Chromosome 8p11 Myeloproliferative Syndrome:

Name: Chromosome 8p11 Myeloproliferative Syndrome 57 29 73
Stem Cell Leukemia/lymphoma 57 59
Myeloid/lymphoid Neoplasm Associated with Fgfr1 Rearrangement 59
Myeloid and Lymphoid Neoplasms with Fgfr1 Rearrangement 73
Stem Cell Leukemia/lymphoma; Scll 57
8p11 Myeloproliferative Syndrome 59
Scll 57

Classifications:



External Ids:

OMIM 57 613523
Orphanet 59 ORPHA168953
ICD10 via Orphanet 34 D47.1

Summaries for Chromosome 8p11 Myeloproliferative Syndrome

OMIM : 57 The 8p11 myeloproliferative syndrome is a rare aggressive condition characterized in its typical form by the occurrence, either simultaneously or sequentially, of a BCR/ABL-negative myeloproliferative disorder and a lymphoma, usually a precursor T-lymphoblastic lymphoma. The disease most often terminates in acute myeloid leukemia (Goradia et al., 2008). (613523)

MalaCards based summary : Chromosome 8p11 Myeloproliferative Syndrome, also known as stem cell leukemia/lymphoma, is related to 8p11 myeloproliferative syndrome and lymphoma. An important gene associated with Chromosome 8p11 Myeloproliferative Syndrome is SCLL (Chromosome 8p11 Myeloproliferative Syndrome). Affiliated tissues include myeloid and t cells.

Related Diseases for Chromosome 8p11 Myeloproliferative Syndrome

Diseases related to Chromosome 8p11 Myeloproliferative Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 8p11 myeloproliferative syndrome 31.7 FGFR1 SCLL
2 lymphoma 10.4
3 leukemia 10.3
4 leukemia, acute myeloid 10.1
5 leukemia, acute lymphoblastic 10.1
6 acute leukemia 10.1
7 hematopoietic stem cell transplantation 10.1
8 lymphoblastic lymphoma 10.1
9 lymphocytic leukemia 10.1
10 myeloid leukemia 10.1

Graphical network of the top 20 diseases related to Chromosome 8p11 Myeloproliferative Syndrome:



Diseases related to Chromosome 8p11 Myeloproliferative Syndrome

Symptoms & Phenotypes for Chromosome 8p11 Myeloproliferative Syndrome

Clinical features from OMIM:

613523

Drugs & Therapeutics for Chromosome 8p11 Myeloproliferative Syndrome

Search Clinical Trials , NIH Clinical Center for Chromosome 8p11 Myeloproliferative Syndrome

Genetic Tests for Chromosome 8p11 Myeloproliferative Syndrome

Genetic tests related to Chromosome 8p11 Myeloproliferative Syndrome:

# Genetic test Affiliating Genes
1 Chromosome 8p11 Myeloproliferative Syndrome 29

Anatomical Context for Chromosome 8p11 Myeloproliferative Syndrome

MalaCards organs/tissues related to Chromosome 8p11 Myeloproliferative Syndrome:

41
Myeloid, T Cells

Publications for Chromosome 8p11 Myeloproliferative Syndrome

Articles related to Chromosome 8p11 Myeloproliferative Syndrome:

# Title Authors Year
1
Distinct signaling programs associated with progression of FGFR1 driven leukemia in a mouse model of stem cell leukemia lymphoma syndrome. ( 30439482 )
2018
2
8p11 Stem Cell Leukemia/Lymphoma Syndrome without Myeloproliferation: A Rare Clinical Entity. ( 29622897 )
2018
3
FGFR1 fusion kinase regulation of MYC expression drives development of stem cell leukemia/lymphoma syndrome. ( 29720732 )
2018
4
miR-339 Promotes Development of Stem Cell Leukemia/Lymphoma Syndrome via Downregulation of the BCL2L11 and BAX Proapoptotic Genes. ( 29735550 )
2018
5
A novel cytogenetic aberration found in stem cell leukemia/lymphoma syndrome. ( 17928887 )
2008
6
CD56+CD7+ stem cell leukemia/lymphoma with D2-Jdelta1 rearrangement. ( 10435360 )
1999
7
Electron microscopical analysis of myeloperoxidase of leukemic cells in CD7+ stem cell leukemia/lymphoma. ( 10359066 )
1999
8
T-stem cell leukemia/lymphoma with both myeloid lineage conversion and T-specific delta recombination. ( 9379684 )
1997
9
Translocation t(8;13)(p11;q11-12) in stem cell leukemia/lymphoma of T-cell and myeloid lineages. ( 7535088 )
1995
10
CD7+ stem cell leukemia/lymphoma. Features of a subgroup without circulating blast cells. ( 7685244 )
1993

Variations for Chromosome 8p11 Myeloproliferative Syndrome

Expression for Chromosome 8p11 Myeloproliferative Syndrome

Search GEO for disease gene expression data for Chromosome 8p11 Myeloproliferative Syndrome.

Pathways for Chromosome 8p11 Myeloproliferative Syndrome

GO Terms for Chromosome 8p11 Myeloproliferative Syndrome

Sources for Chromosome 8p11 Myeloproliferative Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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