SCLL
MCID: CHR375
MIFTS: 22

Chromosome 8p11 Myeloproliferative Syndrome (SCLL)

Categories: Blood diseases, Cancer diseases, Immune diseases, Rare diseases

Aliases & Classifications for Chromosome 8p11 Myeloproliferative Syndrome

MalaCards integrated aliases for Chromosome 8p11 Myeloproliferative Syndrome:

Name: Chromosome 8p11 Myeloproliferative Syndrome 58 30 74
Stem Cell Leukemia/lymphoma 58 60
Myeloid/lymphoid Neoplasm Associated with Fgfr1 Rearrangement 60
Myeloid and Lymphoid Neoplasms with Fgfr1 Rearrangement 74
Stem Cell Leukemia/lymphoma; Scll 58
8p11 Myeloproliferative Syndrome 60
Scll 58

Classifications:



External Ids:

OMIM 58 613523
ICD10 via Orphanet 35 D47.1
Orphanet 60 ORPHA168953

Summaries for Chromosome 8p11 Myeloproliferative Syndrome

OMIM : 58 The 8p11 myeloproliferative syndrome is a rare aggressive condition characterized in its typical form by the occurrence, either simultaneously or sequentially, of a BCR/ABL-negative myeloproliferative disorder and a lymphoma, usually a precursor T-lymphoblastic lymphoma. The disease most often terminates in acute myeloid leukemia (Goradia et al., 2008). (613523)

MalaCards based summary : Chromosome 8p11 Myeloproliferative Syndrome, also known as stem cell leukemia/lymphoma, is related to 8p11 myeloproliferative syndrome and leukemia. An important gene associated with Chromosome 8p11 Myeloproliferative Syndrome is SCLL (Chromosome 8p11 Myeloproliferative Syndrome). Affiliated tissues include myeloid and t cells.

Related Diseases for Chromosome 8p11 Myeloproliferative Syndrome

Diseases related to Chromosome 8p11 Myeloproliferative Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 8p11 myeloproliferative syndrome 31.4 FGFR1 SCLL
2 leukemia 10.4
3 lymphoma 10.4
4 leukemia, acute myeloid 10.1
5 leukemia, acute lymphoblastic 10.1
6 acute leukemia 10.1
7 hematopoietic stem cell transplantation 10.1
8 lymphoblastic lymphoma 10.1
9 lymphocytic leukemia 10.1
10 myeloid leukemia 10.1

Graphical network of the top 20 diseases related to Chromosome 8p11 Myeloproliferative Syndrome:



Diseases related to Chromosome 8p11 Myeloproliferative Syndrome

Symptoms & Phenotypes for Chromosome 8p11 Myeloproliferative Syndrome

Clinical features from OMIM:

613523

Drugs & Therapeutics for Chromosome 8p11 Myeloproliferative Syndrome

Search Clinical Trials , NIH Clinical Center for Chromosome 8p11 Myeloproliferative Syndrome

Genetic Tests for Chromosome 8p11 Myeloproliferative Syndrome

Genetic tests related to Chromosome 8p11 Myeloproliferative Syndrome:

# Genetic test Affiliating Genes
1 Chromosome 8p11 Myeloproliferative Syndrome 30

Anatomical Context for Chromosome 8p11 Myeloproliferative Syndrome

MalaCards organs/tissues related to Chromosome 8p11 Myeloproliferative Syndrome:

42
Myeloid, T Cells

Publications for Chromosome 8p11 Myeloproliferative Syndrome

Articles related to Chromosome 8p11 Myeloproliferative Syndrome:

# Title Authors Year
1
Distinct signaling programs associated with progression of FGFR1 driven leukemia in a mouse model of stem cell leukemia lymphoma syndrome. ( 30439482 )
2018
2
8p11 Stem Cell Leukemia/Lymphoma Syndrome without Myeloproliferation: A Rare Clinical Entity. ( 29622897 )
2018
3
FGFR1 fusion kinase regulation of MYC expression drives development of stem cell leukemia/lymphoma syndrome. ( 29720732 )
2018
4
miR-339 Promotes Development of Stem Cell Leukemia/Lymphoma Syndrome via Downregulation of the BCL2L11 and BAX Proapoptotic Genes. ( 29735550 )
2018
5
A novel cytogenetic aberration found in stem cell leukemia/lymphoma syndrome. ( 17928887 )
2008
6
CD56+CD7+ stem cell leukemia/lymphoma with D2-Jdelta1 rearrangement. ( 10435360 )
1999
7
Electron microscopical analysis of myeloperoxidase of leukemic cells in CD7+ stem cell leukemia/lymphoma. ( 10359066 )
1999
8
T-stem cell leukemia/lymphoma with both myeloid lineage conversion and T-specific delta recombination. ( 9379684 )
1997
9
Translocation t(8;13)(p11;q11-12) in stem cell leukemia/lymphoma of T-cell and myeloid lineages. ( 7535088 )
1995
10
CD7+ stem cell leukemia/lymphoma. Features of a subgroup without circulating blast cells. ( 7685244 )
1993

Variations for Chromosome 8p11 Myeloproliferative Syndrome

Expression for Chromosome 8p11 Myeloproliferative Syndrome

Search GEO for disease gene expression data for Chromosome 8p11 Myeloproliferative Syndrome.

Pathways for Chromosome 8p11 Myeloproliferative Syndrome

GO Terms for Chromosome 8p11 Myeloproliferative Syndrome

Sources for Chromosome 8p11 Myeloproliferative Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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