MCID: CHR264
MIFTS: 14

Chromosome 8p Deletion

Categories: Rare diseases

Aliases & Classifications for Chromosome 8p Deletion

MalaCards integrated aliases for Chromosome 8p Deletion:

Name: Chromosome 8p Deletion 54
Chromosome 8, Monosomy 8p 74
Partial Monosomy 8p 54
8p Deletion 54
8p Monosomy 54
Deletion 8p 54
Monosomy 8p 54

Classifications:



External Ids:

UMLS 74 C0795824

Summaries for Chromosome 8p Deletion

NIH Rare Diseases : 54 Chromosome 8p deletion is a chromosome abnormality that affects many different parts of the body. People with this condition are missing genetic material located on the short arm (p) of chromosome 8 in each cell. The severity of the condition and the associated signs and symptoms vary based on the size and location of the deletion and which genes are involved. Most cases are not inherited, although affected people can pass the deletion on to their children. Treatment is based on the signs and symptoms present in each person.

MalaCards based summary : Chromosome 8p Deletion, also known as chromosome 8, monosomy 8p, is related to 8p inverted duplication/deletion syndrome and hepatocellular carcinoma. An important gene associated with Chromosome 8p Deletion is NKX3-1 (NK3 Homeobox 1). Affiliated tissues include prostate.

Related Diseases for Chromosome 8p Deletion

Diseases related to Chromosome 8p Deletion via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 13)
# Related Disease Score Top Affiliating Genes
1 8p inverted duplication/deletion syndrome 11.3
2 hepatocellular carcinoma 10.1
3 cornelia de lange syndrome 1 10.1
4 holoprosencephaly 10.1
5 cornelia de lange syndrome 10.1
6 colorectal cancer 10.0
7 prostate cancer 10.0
8 prostate cancer, hereditary, 8 10.0
9 prostate cancer, hereditary, 6 10.0
10 adenocarcinoma 10.0
11 status epilepticus 9.9
12 chromosomal triplication 9.9
13 dandy-walker complex 9.9

Graphical network of the top 20 diseases related to Chromosome 8p Deletion:



Diseases related to Chromosome 8p Deletion

Symptoms & Phenotypes for Chromosome 8p Deletion

Drugs & Therapeutics for Chromosome 8p Deletion

Search Clinical Trials , NIH Clinical Center for Chromosome 8p Deletion

Genetic Tests for Chromosome 8p Deletion

Anatomical Context for Chromosome 8p Deletion

MalaCards organs/tissues related to Chromosome 8p Deletion:

42
Prostate

Publications for Chromosome 8p Deletion

Articles related to Chromosome 8p Deletion:

# Title Authors Year
1
Decreased NKX3.1 protein expression in focal prostatic atrophy, prostatic intraepithelial neoplasia, and adenocarcinoma: association with gleason score and chromosome 8p deletion. ( 17108105 )
2006
2
Chromosome 8p deletion is associated with metastasis of human hepatocellular carcinoma when high and low metastatic models are compared. ( 11501747 )
2001
3
Identification of the prostate cancer micro-foci with chromosome 8p deletion at the tumor interface area by histopathological-FISH parallel examination. ( 11713582 )
2001
4
The association of chromosome 8p deletion and tumor metastasis in human hepatocellular carcinoma. ( 10582679 )
1999

Variations for Chromosome 8p Deletion

Expression for Chromosome 8p Deletion

Search GEO for disease gene expression data for Chromosome 8p Deletion.

Pathways for Chromosome 8p Deletion

GO Terms for Chromosome 8p Deletion

Sources for Chromosome 8p Deletion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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