MCID: CHR264
MIFTS: 14

Chromosome 8p Deletion

Categories: Rare diseases

Aliases & Classifications for Chromosome 8p Deletion

MalaCards integrated aliases for Chromosome 8p Deletion:

Name: Chromosome 8p Deletion 53
Chromosome 8, Monosomy 8p 73
Partial Monosomy 8p 53
8p Deletion 53
8p Monosomy 53
Deletion 8p 53
Monosomy 8p 53

Classifications:



External Ids:

UMLS 73 C0795824

Summaries for Chromosome 8p Deletion

NIH Rare Diseases : 53 Chromosome 8p deletion is a chromosome abnormality that affects many different parts of the body. People with this condition are missing genetic material located on the short arm (p) of chromosome 8 in each cell. The severity of the condition and the associated signs and symptoms vary based on the size and location of the deletion and which genes are involved. Most cases are not inherited, although affected people can pass the deletion on to their children. Treatment is based on the signs and symptoms present in each person.

MalaCards based summary : Chromosome 8p Deletion, also known as chromosome 8, monosomy 8p, is related to hepatocellular carcinoma and holoprosencephaly. An important gene associated with Chromosome 8p Deletion is NKX3-1 (NK3 Homeobox 1). Affiliated tissues include prostate.

Related Diseases for Chromosome 8p Deletion

Diseases related to Chromosome 8p Deletion via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 hepatocellular carcinoma 10.1
2 holoprosencephaly 10.0
3 chromosomal triplication 10.0
4 colorectal cancer 10.0
5 prostate cancer 10.0
6 adenocarcinoma 10.0
7 status epilepticus 9.9
8 dandy-walker complex 9.9

Graphical network of the top 20 diseases related to Chromosome 8p Deletion:



Diseases related to Chromosome 8p Deletion

Symptoms & Phenotypes for Chromosome 8p Deletion

Drugs & Therapeutics for Chromosome 8p Deletion

Search Clinical Trials , NIH Clinical Center for Chromosome 8p Deletion

Genetic Tests for Chromosome 8p Deletion

Anatomical Context for Chromosome 8p Deletion

MalaCards organs/tissues related to Chromosome 8p Deletion:

41
Prostate

Publications for Chromosome 8p Deletion

Articles related to Chromosome 8p Deletion:

# Title Authors Year
1
Decreased NKX3.1 protein expression in focal prostatic atrophy, prostatic intraepithelial neoplasia, and adenocarcinoma: association with gleason score and chromosome 8p deletion. ( 17108105 )
2006
2
Identification of the prostate cancer micro-foci with chromosome 8p deletion at the tumor interface area by histopathological-FISH parallel examination. ( 11713582 )
2001
3
Chromosome 8p deletion is associated with metastasis of human hepatocellular carcinoma when high and low metastatic models are compared. ( 11501747 )
2001
4
The association of chromosome 8p deletion and tumor metastasis in human hepatocellular carcinoma. ( 10582679 )
1999

Variations for Chromosome 8p Deletion

Expression for Chromosome 8p Deletion

Search GEO for disease gene expression data for Chromosome 8p Deletion.

Pathways for Chromosome 8p Deletion

GO Terms for Chromosome 8p Deletion

Sources for Chromosome 8p Deletion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....