MCID: CHR463
MIFTS: 36

Chronic Actinic Dermatitis

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Chronic Actinic Dermatitis

MalaCards integrated aliases for Chronic Actinic Dermatitis:

Name: Chronic Actinic Dermatitis 58 71
Actinic Reticuloid 58 71 32
Chronic Photosensitivity Dermatitis 58

Characteristics:

Orphanet epidemiological data:

58
chronic actinic dermatitis
Inheritance: Not applicable; Age of onset: Adult;

Classifications:

Orphanet: 58  
Rare skin diseases


External Ids:

ICD10 32 L57.1
UMLS via Orphanet 72 C0282309 C1510437
Orphanet 58 ORPHA330064
UMLS 71 C0282309 C1510437

Summaries for Chronic Actinic Dermatitis

MalaCards based summary : Chronic Actinic Dermatitis, also known as actinic reticuloid, is related to telangiectasis and skin disease. An important gene associated with Chronic Actinic Dermatitis is CCR7 (C-C Motif Chemokine Receptor 7), and among its related pathways/superpathways are Integrin Pathway and Degradation of the extracellular matrix. Affiliated tissues include lymph node and t cells, and related phenotypes are cutaneous photosensitivity and pruritus

Wikipedia : 74 Chronic actinic dermatitis (also known as "Actinic reticuloid," "Chronic photosensitivity dermatitis,"... more...

Related Diseases for Chronic Actinic Dermatitis

Diseases related to Chronic Actinic Dermatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 151)
# Related Disease Score Top Affiliating Genes
1 telangiectasis 30.2 FBN1 ELN
2 skin disease 29.3 MMP1 FLG ELN
3 dermatitis 11.0
4 dermatitis, atopic 10.6
5 mycosis fungoides 10.6
6 contact dermatitis 10.5
7 cutaneous t cell lymphoma 10.4
8 allergic contact dermatitis 10.3
9 pustulosis of palm and sole 10.3
10 psoriasis 10.3
11 exanthem 10.2
12 adult t-cell leukemia 10.2
13 urticaria 10.2
14 spongiotic dermatitis 10.2
15 t-cell lymphoblastic leukemia/lymphoma 10.2
16 leukemia, t-cell, chronic 10.2
17 solar urticaria 10.2
18 late-onset focal dermal elastosis 10.1 FBN1 ELN
19 pseudoxanthoma elasticum-like papillary dermal elastolysis 10.1 FBN1 ELN
20 familial abdominal aortic aneurysm 10.1 FBN1 ELN
21 mid-dermal elastolysis 10.1 FBN1 ELN
22 ureteric orifice cancer 10.1 FBN1 ELN
23 hemopericardium 10.1 FBN1 ELN
24 senile ectropion 10.1 MMP9 ELN
25 prolapse of urethra 10.1 MMP9 ELN
26 autosomal recessive cutis laxa type i 10.1 FBN1 ELN
27 autosomal recessive cutis laxa type ii classic type 10.1 FBN1 ELN
28 phacogenic glaucoma 10.1 FBN1 ELN
29 arterial tortuosity syndrome 10.1 FBN1 ELN
30 ehlers-danlos syndrome, vascular type 10.1 FBN1 ELN
31 aortic valve insufficiency 10.1 FBN1 ELN
32 mitral valve insufficiency 10.1 FBN1 ELN
33 iris disease 10.1 FBN1 ELN
34 kaposi sarcoma 10.1
35 porphyria cutanea tarda 10.1
36 ataxia-telangiectasia 10.1
37 bloom syndrome 10.1
38 xeroderma pigmentosum, variant type 10.1
39 graft-versus-host disease 10.1
40 erythema multiforme 10.1
41 anaplastic large cell lymphoma 10.1
42 lymphoma 10.1
43 porphyria 10.1
44 hidradenitis 10.1
45 conjunctivitis 10.1
46 b-cell lymphoma 10.1
47 parapsoriasis 10.1
48 lichen planus 10.1
49 pityriasis lichenoides 10.1
50 posttransplant acute limbic encephalitis 10.1

Graphical network of the top 20 diseases related to Chronic Actinic Dermatitis:



Diseases related to Chronic Actinic Dermatitis

Symptoms & Phenotypes for Chronic Actinic Dermatitis

Human phenotypes related to Chronic Actinic Dermatitis:

58 31 (show all 12)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 cutaneous photosensitivity 58 31 hallmark (90%) Very frequent (99-80%) HP:0000992
2 pruritus 58 31 hallmark (90%) Very frequent (99-80%) HP:0000989
3 erythematous papule 58 31 frequent (33%) Frequent (79-30%) HP:0030350
4 epidermal acanthosis 58 31 frequent (33%) Frequent (79-30%) HP:0025092
5 hypopigmented skin patches 58 31 occasional (7.5%) Occasional (29-5%) HP:0001053
6 lichenification 58 31 occasional (7.5%) Occasional (29-5%) HP:0100725
7 late onset atopic dermatitis 58 31 occasional (7.5%) Occasional (29-5%) HP:0007573
8 actinic keratosis 58 31 occasional (7.5%) Occasional (29-5%) HP:0025127
9 progressive hyperpigmentation 58 31 occasional (7.5%) Occasional (29-5%) HP:0007505
10 erythroderma 58 31 very rare (1%) Very rare (<4-1%) HP:0001019
11 allergic rhinitis 58 31 very rare (1%) Very rare (<4-1%) HP:0003193
12 eczema 58 Very frequent (99-80%)

Drugs & Therapeutics for Chronic Actinic Dermatitis

Search Clinical Trials , NIH Clinical Center for Chronic Actinic Dermatitis

Genetic Tests for Chronic Actinic Dermatitis

Anatomical Context for Chronic Actinic Dermatitis

MalaCards organs/tissues related to Chronic Actinic Dermatitis:

40
Lymph Node, T Cells

Publications for Chronic Actinic Dermatitis

Articles related to Chronic Actinic Dermatitis:

(show top 50) (show all 348)
# Title Authors PMID Year
1
Photopatch testing in Chinese patients: A 5-year experience. 61
33576094 2021
2
Photopatch Testing in New Zealand: A 12-Year Retrospective Review. 61
33449480 2021
3
Clinical and pathological findings of chronic actinic dermatitis. 61
33404164 2021
4
Allergic Contact Dermatitis-Induced Stereospecificity. 61
29933255 2021
5
Ultraviolet A rush hardening for chronic actinic dermatitis: Pilot treatment outcomes. 61
33264455 2020
6
Up-regulation of hsa-miR-221-3p induced by UVB affects proliferation and apoptosis of keratinocytes via Bcl-xL/Bax pathway. 61
33351232 2020
7
Upregulation of hsa-miR-31-3p induced by ultraviolet affects keratinocytes permeability barrier by targeting CLDN1. 61
32907715 2020
8
Severe chronic actinic dermatitis treated successfully with Thalidomide. 61
32654185 2020
9
Successful use of apremilast as a steroid-sparing agent in chronic actinic dermatitis. 61
32530535 2020
10
Apremilast in dermatology: A review of literature. 61
32876993 2020
11
The significance of dermoscopy and trichoscopy in differentiation of erythroderma due to various dermatological disorders. 61
33073390 2020
12
Dupilumab for the treatment of chronic actinic dermatitis. 61
32320500 2020
13
Chronic Actinic Dermatitis After Occupational Sensitization to the Epoxy Resin, Bisphenol. 61
32665513 2020
14
Man of stone: A case of a chronic actinic dermatitis mimicking a cutis verticis gyrata. 61
31715028 2020
15
Phototherapy in the Evaluation and Management of Photodermatoses. 61
31753194 2020
16
Primary Cutaneous CD30+ Anaplastic Large T Cell Lymphoma in a Patient Treated with Cyclosporine for Actinic Reticuloid. 61
32274223 2020
17
Chronic Actinic Dermatitis Revisited. 61
31905184 2020
18
A case of chronic actinic dermatitis that responded completely to treatment with oral colostrum-macrophage-activating factor (colostrum-MAF). 61
30951213 2019
19
Case report of chronic actinic dermatitis accompanied by ultraviolet A photosensitivity in a Chrysanthemum farmer. 61
30811065 2019
20
A case report of therapeutically challenging chronic actinic dermatitis. 61
31105944 2019
21
Increased incidence of chronic actinic dermatitis in relation to climate changes and air pollution during the past 15 years in Korea. 61
29889316 2018
22
Mogamulizumab-induced photosensitivity in patients with mycosis fungoides and other T-cell neoplasms. 61
29341283 2018
23
Chronic actinic dermatitis: successful treatment with psoralen-ultraviolet A photochemotherapy. 61
28889653 2018
24
Chronic actinic dermatitis. 61
29530872 2018
25
Photo-patch and patch tests in patients with dermatitis over the photo-exposed areas: A study of 101 cases from a tertiary care centre in India. 61
27282531 2018
26
Evaluation of narrow band ultraviolet B phototherapy in the treatment of chronic actinic dermatitis in Chinese patients. 61
29047198 2017
27
Tacrolimus 0.1% ointment applied under occlusion using cling film clears chronic actinic dermatitis resistant to systemic treatment. 61
28239836 2017
28
Comparison of Demographic and Photobiological Features of Chronic Actinic Dermatitis in Patients With Lighter vs Darker Skin Types. 61
28329062 2017
29
Phenotypic analysis of circulating T-cell subset and its association with burden of skin disease in patients with chronic actinic dermatitis: a hematologic and clinicopathologic study of 20 subjects. 61
28176301 2017
30
Tungsten lamp and chronic actinic dermatitis. 61
26299466 2017
31
Tofacitinib citrate for the treatment of refractory, severe chronic actinic dermatitis. 61
28050588 2017
32
High Altitude Dermatology. 61
28216727 2017
33
Genome-Wide Analysis of mRNA and Long Noncoding RNA Profiles in Chronic Actinic Dermatitis. 61
29359156 2017
34
The clinical severity score of chronic actinic dermatitis correlates with in vivo photoallergic reactions and the immunologic parameters related to a shift towards Th2 immunity from the Th2/Th1 balanced status in patients with chronic actinic dermatitis. 61
27084788 2016
35
Chronic actinic dermatitis occurring in an adult with atopic dermatitis. 61
26990344 2015
36
Human T-lymphotropic virus 1 (HTLV-1)-associated lichenoid dermatitis induced by CD8+ T cells in HTLV-1 carrier, HTLV-1-associated myelopathy/tropical spastic paraparesis and adult T-cell leukemia/lymphoma. 61
26077665 2015
37
Is photodynamic diagnostic flexible ureterorenoscopy suitable for a patient presenting with chronic actinic dermatitis? 61
26012562 2015
38
Loss-of-Function Mutations in the Gene Encoding Filaggrin Are Not Strongly Associated with Chronic Actinic Dermatitis. 61
25734812 2015
39
Hair dye dermatitis and p-phenylenediamine contact sensitivity: A preliminary report. 61
26225326 2015
40
Chronic actinic dermatitis/actinic reticuloid: a clinicopathologic and immunohistochemical analysis of 37 cases. 61
25238449 2014
41
Evidence and conjecture about mechanisms of cutaneous disease in photodermatology. 61
24910168 2014
42
Evaluation of patients with photodermatoses. 61
24891050 2014
43
Chronic actinic dermatitis. 61
24891057 2014
44
The natural history of chronic actinic dermatitis: an analysis at a single institution in the United States. 61
24407058 2014
45
A clinical study of the spectrum of photodermatoses in dark-skinned populations. 61
23758593 2013
46
Energy-saving lamps and their impact on photosensitive and normal individuals. 61
23746038 2013
47
A quantitative assessment of the effects of formal sun protection education on photosensitive patients. 61
24001382 2013
48
Incidence and care of environmental dermatoses in the high-altitude region of ladakh, India. 61
23716798 2013
49
Photodermatoses in pigmented skin. 61
23123922 2013
50
Parthenium dermatitis. 61
23139090 2013

Variations for Chronic Actinic Dermatitis

Expression for Chronic Actinic Dermatitis

Search GEO for disease gene expression data for Chronic Actinic Dermatitis.

Pathways for Chronic Actinic Dermatitis

Pathways related to Chronic Actinic Dermatitis according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.7 MMP9 MMP1 FBN1 ELN CCR7
2
Show member pathways
11.91 MMP9 MMP1 FBN1 ELN
3
Show member pathways
11.49 MMP9 MMP1
4
Show member pathways
11.34 FBN1 ELN
5 11.32 MMP9 MMP1
6
Show member pathways
11.23 MMP9 MMP1
7 11.2 MMP9 ELN
8 11.15 MMP9 MMP1
9 10.85 MMP9 MMP1
10 10.49 MMP9 MMP1
11 10.39 MMP9 MMP1 ELN

GO Terms for Chronic Actinic Dermatitis

Cellular components related to Chronic Actinic Dermatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 collagen-containing extracellular matrix GO:0062023 9.26 MMP9 FLG FBN1 ELN
2 extracellular matrix GO:0031012 8.92 MMP9 MMP1 FBN1 ELN

Biological processes related to Chronic Actinic Dermatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix disassembly GO:0022617 9.26 MMP9 MMP1
2 collagen catabolic process GO:0030574 9.16 MMP9 MMP1
3 cellular response to UV-A GO:0071492 8.96 MMP9 MMP1
4 extracellular matrix organization GO:0030198 8.92 MMP9 MMP1 FBN1 ELN

Molecular functions related to Chronic Actinic Dermatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endopeptidase activity GO:0004175 8.96 MMP9 MMP1
2 extracellular matrix constituent conferring elasticity GO:0030023 8.62 FBN1 ELN

Sources for Chronic Actinic Dermatitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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