MCID: CHR463
MIFTS: 37

Chronic Actinic Dermatitis

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Chronic Actinic Dermatitis

MalaCards integrated aliases for Chronic Actinic Dermatitis:

Name: Chronic Actinic Dermatitis 58 71
Actinic Reticuloid 58 71 32
Chronic Photosensitivity Dermatitis 58

Characteristics:

Orphanet epidemiological data:

58
chronic actinic dermatitis
Inheritance: Not applicable; Age of onset: Adult;

Classifications:

Orphanet: 58  
Rare skin diseases


External Ids:

ICD10 32 L57.1
UMLS via Orphanet 72 C0282309 C1510437
Orphanet 58 ORPHA330064
UMLS 71 C0282309 C1510437

Summaries for Chronic Actinic Dermatitis

MalaCards based summary : Chronic Actinic Dermatitis, also known as actinic reticuloid, is related to telangiectasis and allergic contact dermatitis. An important gene associated with Chronic Actinic Dermatitis is CCR7 (C-C Motif Chemokine Receptor 7), and among its related pathways/superpathways are Integrin Pathway and Degradation of the extracellular matrix. Affiliated tissues include skin, t cells and testes, and related phenotypes are pruritus and cutaneous photosensitivity

Wikipedia : 74 Chronic actinic dermatitis (also known as "Actinic reticuloid," "Chronic photosensitivity dermatitis,"... more...

Related Diseases for Chronic Actinic Dermatitis

Diseases related to Chronic Actinic Dermatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 152)
# Related Disease Score Top Affiliating Genes
1 telangiectasis 30.2 FBN1 ELN
2 allergic contact dermatitis 30.2 FLG CCR7
3 keratosis 29.7 MMP9 FLG
4 skin disease 28.8 MMP1 FLG ELN
5 dermatitis 11.0
6 mycosis fungoides 10.6
7 dermatitis, atopic 10.4
8 contact dermatitis 10.4
9 cutaneous t cell lymphoma 10.3
10 lymphoma 10.2
11 pustulosis of palm and sole 10.2
12 psoriasis 10.2
13 aneurysm 10.1 FBN1 ELN
14 diffuse cutaneous systemic sclerosis 10.1 FBN1 CCR7
15 exanthem 10.1
16 late-onset focal dermal elastosis 10.1 FBN1 ELN
17 pseudoxanthoma elasticum-like papillary dermal elastolysis 10.1 FBN1 ELN
18 familial abdominal aortic aneurysm 10.1 FBN1 ELN
19 mid-dermal elastolysis 10.1 FBN1 ELN
20 ureteric orifice cancer 10.1 FBN1 ELN
21 senile ectropion 10.1 MMP9 ELN
22 autosomal recessive cutis laxa type i 10.1 FBN1 ELN
23 autosomal recessive cutis laxa type ii classic type 10.1 FBN1 ELN
24 phacogenic glaucoma 10.1 FBN1 ELN
25 sarcoma 10.1
26 porphyria 10.1
27 anaplastic large cell lymphoma 10.1
28 erythema multiforme 10.1
29 graft-versus-host disease 10.1
30 xeroderma pigmentosum, variant type 10.1
31 bloom syndrome 10.1
32 ataxia-telangiectasia 10.1
33 porphyria cutanea tarda 10.1
34 kaposi sarcoma 10.1
35 hidradenitis 10.1
36 spindle cell sarcoma 10.1
37 conjunctivitis 10.1
38 b-cell lymphoma 10.1
39 parapsoriasis 10.1
40 lichen planus 10.1
41 pityriasis lichenoides 10.1
42 posttransplant acute limbic encephalitis 10.1
43 cutaneous pseudolymphoma 10.1
44 arterial tortuosity syndrome 10.1 FBN1 ELN
45 aortic valve insufficiency 10.1 FBN1 ELN
46 aortic dissection 10.1 FBN1 ELN
47 iris disease 10.1 FBN1 ELN
48 mitral valve insufficiency 10.1 FBN1 ELN
49 oral submucous fibrosis 10.1 MMP9 ELN
50 cerebral arterial disease 10.1 MMP9 ELN

Graphical network of the top 20 diseases related to Chronic Actinic Dermatitis:



Diseases related to Chronic Actinic Dermatitis

Symptoms & Phenotypes for Chronic Actinic Dermatitis

Human phenotypes related to Chronic Actinic Dermatitis:

58 31 (show all 12)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 pruritus 58 31 hallmark (90%) Very frequent (99-80%) HP:0000989
2 cutaneous photosensitivity 58 31 hallmark (90%) Very frequent (99-80%) HP:0000992
3 erythematous papule 58 31 frequent (33%) Frequent (79-30%) HP:0030350
4 epidermal acanthosis 58 31 frequent (33%) Frequent (79-30%) HP:0025092
5 hypopigmented skin patches 58 31 occasional (7.5%) Occasional (29-5%) HP:0001053
6 lichenification 58 31 occasional (7.5%) Occasional (29-5%) HP:0100725
7 late onset atopic dermatitis 58 31 occasional (7.5%) Occasional (29-5%) HP:0007573
8 actinic keratosis 58 31 occasional (7.5%) Occasional (29-5%) HP:0025127
9 progressive hyperpigmentation 58 31 occasional (7.5%) Occasional (29-5%) HP:0007505
10 erythroderma 58 31 very rare (1%) Very rare (<4-1%) HP:0001019
11 allergic rhinitis 58 31 very rare (1%) Very rare (<4-1%) HP:0003193
12 eczema 58 Very frequent (99-80%)

Drugs & Therapeutics for Chronic Actinic Dermatitis

Search Clinical Trials , NIH Clinical Center for Chronic Actinic Dermatitis

Genetic Tests for Chronic Actinic Dermatitis

Anatomical Context for Chronic Actinic Dermatitis

MalaCards organs/tissues related to Chronic Actinic Dermatitis:

40
Skin, T Cells, Testes, Lymph Node, Neutrophil

Publications for Chronic Actinic Dermatitis

Articles related to Chronic Actinic Dermatitis:

(show top 50) (show all 338)
# Title Authors PMID Year
1
Successful use of apremilast as a steroid-sparing agent in chronic actinic dermatitis. 61
32530535 2020
2
Dupilumab for the treatment of chronic actinic dermatitis. 61
32320500 2020
3
Man of stone: A case of a chronic actinic dermatitis mimicking a cutis verticis gyrata. 61
31715028 2020
4
Primary Cutaneous CD30+ Anaplastic Large T Cell Lymphoma in a Patient Treated with Cyclosporine for Actinic Reticuloid. 61
32274223 2020
5
Phototherapy in the Evaluation and Management of Photodermatoses. 61
31753194 2020
6
Chronic Actinic Dermatitis Revisited. 61
31905184 2020
7
Case report of chronic actinic dermatitis accompanied by ultraviolet A photosensitivity in a Chrysanthemum farmer. 61
30811065 2019
8
A case of chronic actinic dermatitis that responded completely to treatment with oral colostrum-macrophage-activating factor (colostrum-MAF). 61
30951213 2019
9
A case report of therapeutically challenging chronic actinic dermatitis. 61
31105944 2019
10
Increased incidence of chronic actinic dermatitis in relation to climate changes and air pollution during the past 15 years in Korea. 61
29889316 2018
11
Mogamulizumab-induced photosensitivity in patients with mycosis fungoides and other T-cell neoplasms. 61
29341283 2018
12
Allergic Contact Dermatitis-Induced Stereospecificity Overview. 61
29933255 2018
13
Chronic actinic dermatitis: successful treatment with psoralen-ultraviolet A photochemotherapy. 61
28889653 2018
14
Chronic actinic dermatitis. 61
29530872 2018
15
Photo-patch and patch tests in patients with dermatitis over the photo-exposed areas: A study of 101 cases from a tertiary care centre in India. 61
27282531 2018
16
Evaluation of narrow band ultraviolet B phototherapy in the treatment of chronic actinic dermatitis in Chinese patients. 61
29047198 2017
17
Tacrolimus 0.1% ointment applied under occlusion using cling film clears chronic actinic dermatitis resistant to systemic treatment. 61
28239836 2017
18
Comparison of Demographic and Photobiological Features of Chronic Actinic Dermatitis in Patients With Lighter vs Darker Skin Types. 61
28329062 2017
19
Phenotypic analysis of circulating T-cell subset and its association with burden of skin disease in patients with chronic actinic dermatitis: a hematologic and clinicopathologic study of 20 subjects. 61
28176301 2017
20
Tungsten lamp and chronic actinic dermatitis. 61
26299466 2017
21
Tofacitinib citrate for the treatment of refractory, severe chronic actinic dermatitis. 61
28050588 2017
22
High Altitude Dermatology. 61
28216727 2017
23
Genome-Wide Analysis of mRNA and Long Noncoding RNA Profiles in Chronic Actinic Dermatitis. 61
29359156 2017
24
The clinical severity score of chronic actinic dermatitis correlates with in vivo photoallergic reactions and the immunologic parameters related to a shift towards Th2 immunity from the Th2/Th1 balanced status in patients with chronic actinic dermatitis. 61
27084788 2016
25
Chronic actinic dermatitis occurring in an adult with atopic dermatitis. 61
26990344 2015
26
Human T-lymphotropic virus 1 (HTLV-1)-associated lichenoid dermatitis induced by CD8+ T cells in HTLV-1 carrier, HTLV-1-associated myelopathy/tropical spastic paraparesis and adult T-cell leukemia/lymphoma. 61
26077665 2015
27
Is photodynamic diagnostic flexible ureterorenoscopy suitable for a patient presenting with chronic actinic dermatitis? 61
26012562 2015
28
Loss-of-Function Mutations in the Gene Encoding Filaggrin Are Not Strongly Associated with Chronic Actinic Dermatitis. 61
25734812 2015
29
Hair dye dermatitis and p-phenylenediamine contact sensitivity: A preliminary report. 61
26225326 2015
30
Chronic actinic dermatitis/actinic reticuloid: a clinicopathologic and immunohistochemical analysis of 37 cases. 61
25238449 2014
31
Evidence and conjecture about mechanisms of cutaneous disease in photodermatology. 61
24910168 2014
32
Evaluation of patients with photodermatoses. 61
24891050 2014
33
Chronic actinic dermatitis. 61
24891057 2014
34
The natural history of chronic actinic dermatitis: an analysis at a single institution in the United States. 61
24407058 2014
35
A clinical study of the spectrum of photodermatoses in dark-skinned populations. 61
23758593 2013
36
Energy-saving lamps and their impact on photosensitive and normal individuals. 61
23746038 2013
37
A quantitative assessment of the effects of formal sun protection education on photosensitive patients. 61
24001382 2013
38
Incidence and care of environmental dermatoses in the high-altitude region of ladakh, India. 61
23716798 2013
39
Parthenium dermatitis. 61
23139090 2013
40
Photodermatoses in pigmented skin. 61
23123922 2013
41
Origin Use of CD4, CD8, and CD1a Immunostains in Distinguishing Mycosis Fungoides from its Inflammatory Mimics: A Pilot Study. 61
23248358 2012
42
Actinic reticuloid imitating Sézary syndrome. 61
23267873 2012
43
Parthenium dermatitis in India: past, present and future. 61
22960811 2012
44
A case of false-negative monochromator phototesting in a patient with chronic actinic dermatitis taking prednisolone. 61
22250731 2012
45
A photosensitive pseudolymphomatous eruption. Actinic reticuloid (AR). 61
22340697 2012
46
Actinic reticuloid presented as facies leonine. 61
22250638 2012
47
Chronic actinic dermatitis: two patients with successful management using narrowband ultraviolet B phototherapy with systemic steroids. 61
22031690 2011
48
Actinic reticuloid--photosensitivity or pseudolymphoma?--A review. 61
22220464 2011
49
Chronic actinic dermatitis in Asian skin: a Singaporean experience. 61
21729163 2011
50
[Chronic actinic dermatitis. Therapy with systemic PUVA and mycophenolate mofetil]. 61
20941470 2011

Variations for Chronic Actinic Dermatitis

Expression for Chronic Actinic Dermatitis

Search GEO for disease gene expression data for Chronic Actinic Dermatitis.

Pathways for Chronic Actinic Dermatitis

Pathways related to Chronic Actinic Dermatitis according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.7 MMP9 MMP1 FBN1 ELN CCR7
2
Show member pathways
11.91 MMP9 MMP1 FBN1 ELN
3
Show member pathways
11.49 MMP9 MMP1
4
Show member pathways
11.34 FBN1 ELN
5 11.32 MMP9 MMP1
6
Show member pathways
11.23 MMP9 MMP1
7 11.2 MMP9 ELN
8 11.15 MMP9 MMP1
9 10.85 MMP9 MMP1
10 10.49 MMP9 MMP1
11 10.39 MMP9 MMP1 ELN

GO Terms for Chronic Actinic Dermatitis

Cellular components related to Chronic Actinic Dermatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 collagen-containing extracellular matrix GO:0062023 9.26 MMP9 FLG FBN1 ELN
2 extracellular matrix GO:0031012 8.92 MMP9 MMP1 FBN1 ELN

Biological processes related to Chronic Actinic Dermatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix disassembly GO:0022617 9.16 MMP9 MMP1
2 collagen catabolic process GO:0030574 8.96 MMP9 MMP1
3 extracellular matrix organization GO:0030198 8.92 MMP9 MMP1 FBN1 ELN

Molecular functions related to Chronic Actinic Dermatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endopeptidase activity GO:0004175 8.96 MMP9 MMP1
2 extracellular matrix constituent conferring elasticity GO:0030023 8.62 FBN1 ELN

Sources for Chronic Actinic Dermatitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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