Aliases & Classifications for Chronic Angina

MalaCards integrated aliases for Chronic Angina:

Name: Chronic Angina 38

Summaries for Chronic Angina

MalaCards based summary : Chronic Angina is related to angina pectoris and ischemia. An important gene associated with Chronic Angina is NF2 (Neurofibromin 2). The drugs Ranolazine and Nitroglycerin have been mentioned in the context of this disorder. Affiliated tissues include heart, bone and brain.

Related Diseases for Chronic Angina

Graphical network of the top 20 diseases related to Chronic Angina:



Diseases related to Chronic Angina

Symptoms & Phenotypes for Chronic Angina

Drugs & Therapeutics for Chronic Angina

Drugs for Chronic Angina (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ranolazine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 142387-99-3, 95635-55-5 56959
2
Nitroglycerin Approved, Investigational Phase 4 55-63-0 4510
3 Adrenergic beta-Antagonists Phase 4,Phase 2
4 Diuretics, Potassium Sparing Phase 4,Phase 3,Phase 2,Not Applicable
5 Sodium Channel Blockers Phase 4,Phase 3,Phase 2,Not Applicable
6
Amlodipine Approved Phase 3 88150-42-9 2162
7 Antihypertensive Agents Phase 3,Phase 2
8 calcium channel blockers Phase 3
9 Calcium, Dietary Phase 3
10 Vasodilator Agents Phase 3
11
Atenolol Approved Phase 2 29122-68-7 2249
12 Adrenergic Agents Phase 2
13 Adrenergic Antagonists Phase 2
14 Adrenergic beta-1 Receptor Antagonists Phase 2
15 Anti-Arrhythmia Agents Phase 2
16 Autonomic Agents Phase 2
17 Neurotransmitter Agents Phase 2
18 Peripheral Nervous System Agents Phase 2
19 Sympatholytics Phase 2

Interventional clinical trials:

(show all 18)
# Name Status NCT ID Phase Drugs
1 An Open-label, Multi-center Study Evaluating the Validity, Reliability, and Responsiveness of a New Female-specific Angina Questionnaire in Women With Chronic Angina Treated With Ranolazine Extended-release Tablets (CVT 3041) Completed NCT00644332 Phase 4 Ranolazine
2 Type 2 Diabetes Evaluation of Ranolazine in Subjects With Chronic Stable Angina Completed NCT01425359 Phase 4 Ranolazine;Ranolazine placebo
3 Ranolazine Versus Placebo Effects on Exercise Tolerance in Patients With Heart Disease and Peripheral Arterial Disease Withdrawn NCT00657514 Phase 4 Ranolazine;Placebo
4 A Study on the Effects of Ranolazine on Exercise Duration in Subjects With Chronic Stable Angina and Coronary Artery Disease (CAD) With Type 2 Diabetes Mellitus (T2DM) Withdrawn NCT01334203 Phase 4 Ranolazine
5 Ranolazine SR in Patients With Chronic Angina Who Remain Symptomatic Despite Maximal Treatment With Amlodipine Completed NCT00091429 Phase 3 Ranolazine
6 Ranolazine for Incomplete Vessel Revascularization Post-Percutaneous Coronary Intervention (PCI) Completed NCT01442038 Phase 3 Ranolazine;Placebo
7 Effect of External Counter Pulsation on Coronary Artery Disease Recruiting NCT03075124 Phase 3
8 Effect of Ranolazine on Gastrointestinal Motor Function and Pain in Patients With IBS-D Terminated NCT02239926 Phase 2, Phase 3 Ranolazine;Placebo
9 To Assess the Anti-anginal Safety and Efficacy of Ivabradine in Subjects With Stable,Symptomatic Chronic Angina Unknown status NCT02623569 Phase 2 Ivabradine;Atenolol
10 A Study to Treat Patients Whose Chronic Angina Symptoms Are Not Relieved by Medication and Have an Area of the Heart That Cannot be Treated by Standard Therapies Completed NCT00215696 Phase 2
11 Study of Ranolazine in Myotonia Congenita, Paramyotonia Congenita and Myotonic Dystrophy Type 1 Completed NCT02251457 Phase 2 Ranolazine
12 Extracorporeal Shockwave Therapy for the Treatment of Refractory Chronic Angina Pectoris Unknown status NCT01567644 Phase 1
13 A Clinical Trial of a Self-Management Education Program for People With Chronic Stable Angina Unknown status NCT00350922 Phase 1
14 Extracorporeal Shockwave Therapy for the Treatment of Chronic Angina Pectoris Suspended NCT01567592 Phase 1
15 Treatment With Ranolazine in Microvascular Coronary Dysfunction (MCD): Impact on Angina Myocardial Ischemia Completed NCT01342029 Not Applicable Ranolazine;Placebo
16 Novel Vitality Indices Derived From the Hexoskin in Patients Affected With Angina Undergoing Coronary Revascularization or Medical Therapy Recruiting NCT02591758
17 REDUCER-I: An Observational Study of the Neovasc Reducerâ„¢ System Recruiting NCT02710435
18 Azilsartan Medoxomil in Hypertensive pAtients With Stable Ischemic Heart Disease and DiabEtes MEllitus. Not yet recruiting NCT03539627 Azilsartan Medoxomil 40 MG Oral Tablet [Edarbi]

Search NIH Clinical Center for Chronic Angina

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Chronic Angina cell therapies at LifeMap Discovery.

Genetic Tests for Chronic Angina

Anatomical Context for Chronic Angina

MalaCards organs/tissues related to Chronic Angina:

41
Heart, Bone, Brain, Spinal Cord

Publications for Chronic Angina

Articles related to Chronic Angina:

(show all 37)
# Title Authors Year
1
A comprehensive meta-analysis of stem cell therapy for chronic angina. ( 29664162 )
2018
2
Differential proteome profile in ischemic heart disease: Prognostic value in chronic angina versus myocardial infarction. A proof of concept. ( 28501389 )
2017
3
Improvement of Subjective Well-Being by Ranolazine in Patients with Chronic Angina and Known Myocardial Ischemia (IMWELL Study). ( 28044265 )
2017
4
Papillary fibroelastoma of the aortic valve presenting with chronic angina and acute stroke: a case report. ( 28095921 )
2017
5
Assessing Quality of Life and Medical Care in Chronic Angina: An Internet Survey. ( 27125492 )
2016
6
A literature review to evaluate the economic value of ranolazine for the symptomatic treatment of chronic angina pectoris. ( 26994453 )
2016
7
Ranolazine reduces angina frequency and severity and improves quality of life: Observational study in patients with chronic angina under ranolazine treatment in Greece (OSCAR-GR). ( 26730841 )
2016
8
Pharmacological and emerging therapies in the treatment of chronic angina. ( 26334161 )
2015
9
Ranolazine for the symptomatic treatment of patients with chronic angina pectoris in Greece: a cost-utility study. ( 26684327 )
2015
10
Cost-Utility Of Ranolazine For The Symptomatic Treatment Of Patients With Chronic Angina Pectoris In Greece. ( 26532231 )
2015
11
Effects of Ranolazine in Patients With Chronic Angina in Patients With and Without Percutaneous Coronary Intervention for Acute Coronary Syndrome: Observations From the MERLIN-TIMI 36 Trial. ( 26059896 )
2015
12
Relation between N-terminal pro-brain natriuretic peptide levels and response to enhanced external counterpulsation in chronic angina pectoris. ( 24217402 )
2014
13
The challenges with chronic angina. ( 25176137 )
2014
14
Comparative short-term effect of once-daily molsidomine on chronic angina in general practitioners' versus cardiologists' coronary patient populations. ( 24307221 )
2014
15
Sexual function in patients with chronic angina pectoris. ( 23558039 )
2013
16
Cost-utility of ranolazine for the symptomatic treatment of patients with chronic angina pectoris in Spain. ( 24122303 )
2013
17
Safety and Efficacy of Ranolazine for the Treatment of Chronic Angina Pectoris. ( 24574825 )
2013
18
Ranolazine reduces patient-reported angina severity and frequency and improves quality of life in selected patients with chronic angina. ( 23990357 )
2013
19
Effects of ranolazine on exercise tolerance and angina frequency in patients with severe chronic angina receiving maximally-tolerated background therapy: analysis from the Combination Assessment of Ranolazine In Stable Angina (CARISA) randomized trial. ( 22689417 )
2012
20
Granulocyte colony stimulating factor in chronic angina to stimulate neovascularisation: a placebo controlled crossover trial. ( 22115984 )
2012
21
Effects of enhanced external counterpulsation on arterial stiffness and myocardial oxygen demand in patients with chronic angina pectoris. ( 21420062 )
2011
22
Letter by Gloekler et al regarding article, "Enhanced external counterpulsation improves peripheral artery flow-mediated dilation in patients with chronic angina: a randomized sham-controlled study". ( 21670237 )
2011
23
The coronary sinus reducer stent for the treatment of chronic angina pectoris. ( 22060309 )
2011
24
Revascularization trumps medicine for patients with type 2 diabetes mellitus and chronic angina (or does it?). ( 21444884 )
2011
25
Grading chronic angina pectoris (myocardial ischemia). ( 20235212 )
2010
26
Therapeutic goals in patients with refractory chronic angina. ( 20450851 )
2010
27
Enhanced external counterpulsation improves peripheral artery flow-mediated dilation in patients with chronic angina: a randomized sham-controlled study. ( 20921442 )
2010
28
Enhanced external counterpulsation for chronic angina pectoris. ( 20166092 )
2010
29
Efficacy of ranolazine in patients with chronic angina observations from the randomized, double-blind, placebo-controlled MERLIN-TIMI (Metabolic Efficiency With Ranolazine for Less Ischemia in Non-ST-Segment Elevation Acute Coronary Syndromes) 36 Trial. ( 19389561 )
2009
30
Chronic angina and the treatment with ranolazine: facts and recommendations. ( 19737166 )
2009
31
Does percutaneous coronary intervention reduce mortality in patients with stable chronic angina: are we talking about apples and oranges? ( 20031824 )
2009
32
Clopidogrel inhibits platelet aggregation in patients on aspirin with stable chronic angina pectoris. ( 17320208 )
2008
33
Novel therapeutic approaches to treating chronic angina in the setting of chronic ischemic heart disease. ( 18373327 )
2007
34
Spinal cord stimulation for refractory chronic angina pectoris: influence on quality of life. ( 20528416 )
2007
35
Gender comparison of efficacy and safety of ranolazine for chronic angina pectoris in four randomized clinical trials. ( 17196454 )
2007
36
Plasminogen activator inhibitor-1 levels in patients with chronic angina pectoris with or without angiographic evidence of coronary sclerosis. ( 2119522 )
1990
37
Effects of the calcium antagonist, isradipine, and nifedipine on resting and exercise haemodynamics and the neurohumoral system in patients with stable chronic angina. ( 2141313 )
1990

Variations for Chronic Angina

Expression for Chronic Angina

Search GEO for disease gene expression data for Chronic Angina.

Pathways for Chronic Angina

GO Terms for Chronic Angina

Cellular components related to Chronic Angina according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apical part of cell GO:0045177 8.62 NF2 REN

Biological processes related to Chronic Angina according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of blood pressure GO:0008217 8.62 NPPB REN

Molecular functions related to Chronic Angina according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 8.62 NPPB REN

Sources for Chronic Angina

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....