Aliases & Classifications for Chronic Angina

MalaCards integrated aliases for Chronic Angina:

Name: Chronic Angina 38

Summaries for Chronic Angina

MalaCards based summary : Chronic Angina is related to arteries, anomalies of and heart disease. An important gene associated with Chronic Angina is NPPB (Natriuretic Peptide B). The drugs Ranolazine and Nitroglycerin have been mentioned in the context of this disorder. Affiliated tissues include heart, bone and spinal cord.

Related Diseases for Chronic Angina

Graphical network of the top 20 diseases related to Chronic Angina:



Diseases related to Chronic Angina

Symptoms & Phenotypes for Chronic Angina

Drugs & Therapeutics for Chronic Angina

Drugs for Chronic Angina (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 30)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ranolazine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 142387-99-3, 95635-55-5 56959
2
Nitroglycerin Approved, Investigational Phase 4 55-63-0 4510
3 Edoxaban Approved Phase 4 480449-70-5
4
Clopidogrel Approved Phase 4 113665-84-2, 120202-66-6 60606
5
Serine Approved, Nutraceutical Phase 4 56-45-1 5951
6 Adrenergic beta-Antagonists Phase 4,Phase 2
7 Sodium Channel Blockers Phase 4,Phase 3,Phase 2,Not Applicable
8 Diuretics, Potassium Sparing Phase 4,Phase 3,Phase 2,Not Applicable
9
protease inhibitors Phase 4
10 Factor Xa Inhibitors Phase 4
11 Antithrombin III Phase 4
12 HIV Protease Inhibitors Phase 4
13 Antithrombins Phase 4
14 Platelet Aggregation Inhibitors Phase 4
15 Anticoagulants Phase 4
16 Serine Proteinase Inhibitors Phase 4
17
Amlodipine Approved Phase 3 88150-42-9 2162
18 Antihypertensive Agents Phase 3,Phase 2
19 Calcium, Dietary Phase 3
20 Vasodilator Agents Phase 3
21 calcium channel blockers Phase 3
22
Atenolol Approved Phase 2 29122-68-7 2249
23 Neurotransmitter Agents Phase 2
24 Adrenergic beta-1 Receptor Antagonists Phase 2
25 Adrenergic Antagonists Phase 2
26 Peripheral Nervous System Agents Phase 2
27 Autonomic Agents Phase 2
28 Anti-Arrhythmia Agents Phase 2
29 Sympatholytics Phase 2
30 Adrenergic Agents Phase 2

Interventional clinical trials:

(show all 19)
# Name Status NCT ID Phase Drugs
1 An Open-label, Multi-center Study Evaluating the Validity, Reliability, and Responsiveness of a New Female-specific Angina Questionnaire in Women With Chronic Angina Treated With Ranolazine Extended-release Tablets (CVT 3041) Completed NCT00644332 Phase 4 Ranolazine
2 Type 2 Diabetes Evaluation of Ranolazine in Subjects With Chronic Stable Angina Completed NCT01425359 Phase 4 Ranolazine;Ranolazine placebo
3 Edoxaban Versus Edoxaban With antiPlatelet Agent In Patients With Atrial Fibrillation and Chronic Stable Coronary Artery Disease Not yet recruiting NCT03718559 Phase 4 Edoxaban;Antiplatelet Agents
4 Ranolazine Versus Placebo Effects on Exercise Tolerance in Patients With Heart Disease and Peripheral Arterial Disease Withdrawn NCT00657514 Phase 4 Ranolazine;Placebo
5 A Study on the Effects of Ranolazine on Exercise Duration in Subjects With Chronic Stable Angina and Coronary Artery Disease (CAD) With Type 2 Diabetes Mellitus (T2DM) Withdrawn NCT01334203 Phase 4 Ranolazine
6 Ranolazine SR in Patients With Chronic Angina Who Remain Symptomatic Despite Maximal Treatment With Amlodipine Completed NCT00091429 Phase 3 Ranolazine
7 Ranolazine for Incomplete Vessel Revascularization Post-Percutaneous Coronary Intervention (PCI) Completed NCT01442038 Phase 3 Ranolazine;Placebo
8 Effect of External Counter Pulsation on Coronary Artery Disease Recruiting NCT03075124 Phase 3
9 Effect of Ranolazine on Gastrointestinal Motor Function and Pain in Patients With IBS-D Terminated NCT02239926 Phase 2, Phase 3 Ranolazine;Placebo
10 To Assess the Anti-anginal Safety and Efficacy of Ivabradine in Subjects With Stable,Symptomatic Chronic Angina Unknown status NCT02623569 Phase 2 Ivabradine;Atenolol
11 A Study to Treat Patients Whose Chronic Angina Symptoms Are Not Relieved by Medication and Have an Area of the Heart That Cannot be Treated by Standard Therapies Completed NCT00215696 Phase 2
12 Study of Ranolazine in Myotonia Congenita, Paramyotonia Congenita and Myotonic Dystrophy Type 1 Completed NCT02251457 Phase 2 Ranolazine
13 Extracorporeal Shockwave Therapy for the Treatment of Refractory Chronic Angina Pectoris Unknown status NCT01567644 Phase 1
14 A Clinical Trial of a Self-Management Education Program for People With Chronic Stable Angina Unknown status NCT00350922 Phase 1
15 Extracorporeal Shockwave Therapy for the Treatment of Chronic Angina Pectoris Suspended NCT01567592 Phase 1
16 Treatment With Ranolazine in Microvascular Coronary Dysfunction (MCD): Impact on Angina Myocardial Ischemia Completed NCT01342029 Not Applicable Ranolazine;Placebo
17 Novel Vitality Indices Derived From the Hexoskin in Patients Affected With Angina Undergoing Coronary Revascularization or Medical Therapy Completed NCT02591758
18 REDUCER-I: An Observational Study of the Neovasc Reducer™ System Recruiting NCT02710435
19 Azilsartan Medoxomil in Hypertensive pAtients With Stable Ischemic Heart Disease and DiabEtes MEllitus. Not yet recruiting NCT03539627 Azilsartan Medoxomil 40 MG Oral Tablet [Edarbi]

Search NIH Clinical Center for Chronic Angina

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Chronic Angina cell therapies at LifeMap Discovery.

Genetic Tests for Chronic Angina

Anatomical Context for Chronic Angina

MalaCards organs/tissues related to Chronic Angina:

41
Heart, Bone, Spinal Cord, Skin, Testes, Brain, Kidney

Publications for Chronic Angina

Articles related to Chronic Angina:

(show top 50) (show all 105)
# Title Authors Year
1
A comprehensive meta-analysis of stem cell therapy for chronic angina. ( 29664162 )
2018
2
Long-term prognosis of unheralded myocardial infarction vs chronic angina; role of sex and coronary atherosclerosis burden. ( 30064378 )
2018
3
The coronary sinus Reducer device for refractory chronic angina: rationale, clinical evidence and future perspectives. ( 30179051 )
2018
4
Ranolazine in patients with type 2 diabetes and chronic angina: A cost-effectiveness analysis and assessment of health-related quality-of-life. ( 30266352 )
2018
5
Differential proteome profile in ischemic heart disease: Prognostic value in chronic angina versus myocardial infarction. A proof of concept. ( 28501389 )
2017
6
Improvement of Subjective Well-Being by Ranolazine in Patients with Chronic Angina and Known Myocardial Ischemia (IMWELL Study). ( 28044265 )
2017
7
Papillary fibroelastoma of the aortic valve presenting with chronic angina and acute stroke: a case report. ( 28095921 )
2017
8
Erratum to: Improvement of Subjective Well-Being by Ranolazine in Patients with Chronic Angina and Known Myocardial Ischemia (IMWELL Study). ( 28105560 )
2017
9
Assessing Quality of Life and Medical Care in Chronic Angina: An Internet Survey. ( 27125492 )
2016
10
A literature review to evaluate the economic value of ranolazine for the symptomatic treatment of chronic angina pectoris. ( 26994453 )
2016
11
Ranolazine reduces angina frequency and severity and improves quality of life: Observational study in patients with chronic angina under ranolazine treatment in Greece (OSCAR-GR). ( 26730841 )
2016
12
Pharmacological and emerging therapies in the treatment of chronic angina. ( 26334161 )
2015
13
Ranolazine for the symptomatic treatment of patients with chronic angina pectoris in Greece: a cost-utility study. ( 26684327 )
2015
14
Cost-Utility Of Ranolazine For The Symptomatic Treatment Of Patients With Chronic Angina Pectoris In Greece. ( 26532231 )
2015
15
Effects of Ranolazine in Patients With Chronic Angina in Patients With and Without Percutaneous Coronary Intervention for Acute Coronary Syndrome: Observations From the MERLIN-TIMI 36 Trial. ( 26059896 )
2015
16
Relation between N-terminal pro-brain natriuretic peptide levels and response to enhanced external counterpulsation in chronic angina pectoris. ( 24217402 )
2014
17
The challenges with chronic angina. ( 25176137 )
2014
18
Comparative short-term effect of once-daily molsidomine on chronic angina in general practitioners' versus cardiologists' coronary patient populations. ( 24307221 )
2014
19
Sexual function in patients with chronic angina pectoris. ( 23558039 )
2013
20
Cost-utility of ranolazine for the symptomatic treatment of patients with chronic angina pectoris in Spain. ( 24122303 )
2013
21
Safety and Efficacy of Ranolazine for the Treatment of Chronic Angina Pectoris. ( 24574825 )
2013
22
Ranolazine reduces patient-reported angina severity and frequency and improves quality of life in selected patients with chronic angina. ( 23990357 )
2013
23
Effects of ranolazine on exercise tolerance and angina frequency in patients with severe chronic angina receiving maximally-tolerated background therapy: analysis from the Combination Assessment of Ranolazine In Stable Angina (CARISA) randomized trial. ( 22689417 )
2012
24
Granulocyte colony stimulating factor in chronic angina to stimulate neovascularisation: a placebo controlled crossover trial. ( 22115984 )
2012
25
Effects of enhanced external counterpulsation on arterial stiffness and myocardial oxygen demand in patients with chronic angina pectoris. ( 21420062 )
2011
26
Letter by Gloekler et al regarding article, "Enhanced external counterpulsation improves peripheral artery flow-mediated dilation in patients with chronic angina: a randomized sham-controlled study". ( 21670237 )
2011
27
The coronary sinus reducer stent for the treatment of chronic angina pectoris. ( 22060309 )
2011
28
Revascularization trumps medicine for patients with type 2 diabetes mellitus and chronic angina (or does it?). ( 21444884 )
2011
29
Grading chronic angina pectoris (myocardial ischemia). ( 20235212 )
2010
30
Therapeutic goals in patients with refractory chronic angina. ( 20450851 )
2010
31
Enhanced external counterpulsation improves peripheral artery flow-mediated dilation in patients with chronic angina: a randomized sham-controlled study. ( 20921442 )
2010
32
Enhanced external counterpulsation for chronic angina pectoris. ( 20166092 )
2010
33
Efficacy of ranolazine in patients with chronic angina observations from the randomized, double-blind, placebo-controlled MERLIN-TIMI (Metabolic Efficiency With Ranolazine for Less Ischemia in Non-ST-Segment Elevation Acute Coronary Syndromes) 36 Trial. ( 19389561 )
2009
34
Chronic angina and the treatment with ranolazine: facts and recommendations. ( 19737166 )
2009
35
Does percutaneous coronary intervention reduce mortality in patients with stable chronic angina: are we talking about apples and oranges? ( 20031824 )
2009
36
Introduction: Update on the evaluation and treatment of chronic angina. ( 19898282 )
2009
37
Getting with the ACC/AHA guidelines for the treatment of chronic angina as a disease state. ( 19898283 )
2009
38
Evaluating medical, percutaneous coronary intervention, and coronary artery bypass surgery options for chronic angina: an update of the revised guidelines. ( 19898284 )
2009
39
Chronic angina: definition, prevalence, and implications for quality of life. ( 19898285 )
2009
40
Cardiovascular imaging to risk-stratify in chronic angina. ( 19898286 )
2009
41
Clopidogrel inhibits platelet aggregation in patients on aspirin with stable chronic angina pectoris. ( 17320208 )
2008
42
Improvements in physical and mental domains of quality of life by anti-ischaemic drug and revascularisation treatment in elderly men and women with chronic angina. ( 18208833 )
2008
43
Expanding the understanding of the treatment of chronic angina: a 21st century approach--part 1. ( 18543302 )
2008
44
Expanding the understanding of the treatment of chronic angina: a 21st century approach-part II. ( 18636470 )
2008
45
Passive tobacco exposure may impair symptomatic improvement in patients with chronic angina undergoing enhanced external counterpulsation. ( 18798998 )
2008
46
Novel therapeutic approaches to treating chronic angina in the setting of chronic ischemic heart disease. ( 18373327 )
2007
47
Spinal cord stimulation for refractory chronic angina pectoris: influence on quality of life. ( 20528416 )
2007
48
Gender comparison of efficacy and safety of ranolazine for chronic angina pectoris in four randomized clinical trials. ( 17196454 )
2007
49
Effect of diuretic therapy on exercise capacity in patients with chronic angina and preserved left ventricular function. ( 17513945 )
2007
50
2007 chronic angina focused update of the ACC/AHA 2002 Guidelines for the management of patients with chronic stable angina: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines Writing Group to develop the focused update of the 2002 Guidelines for the management of patients with chronic stable angina. ( 17998462 )
2007

Variations for Chronic Angina

Expression for Chronic Angina

Search GEO for disease gene expression data for Chronic Angina.

Pathways for Chronic Angina

GO Terms for Chronic Angina

Cellular components related to Chronic Angina according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apical part of cell GO:0045177 8.62 NF2 REN

Biological processes related to Chronic Angina according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of blood pressure GO:0008217 8.62 NPPB REN

Molecular functions related to Chronic Angina according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 8.62 NPPB REN

Sources for Chronic Angina

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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