MCID: CHR013
MIFTS: 32

Chronic Apical Periodontitis

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Chronic Apical Periodontitis

MalaCards integrated aliases for Chronic Apical Periodontitis:

Name: Chronic Apical Periodontitis 12 15 71 32

Classifications:



External Ids:

Disease Ontology 12 DOID:11269
ICD9CM 34 522.6
SNOMED-CT 67 87782002
ICD10 32 K04.5
UMLS 71 C0392492

Summaries for Chronic Apical Periodontitis

MalaCards based summary : Chronic Apical Periodontitis is related to periodontitis and dental pulp necrosis. An important gene associated with Chronic Apical Periodontitis is TNFSF11 (TNF Superfamily Member 11), and among its related pathways/superpathways are RANK Signaling in Osteoclasts and Osteoclast differentiation. The drugs Epinephrine and Racepinephrine have been mentioned in the context of this disorder. Affiliated tissues include bone, heart and salivary gland, and related phenotype is limbs/digits/tail.

Related Diseases for Chronic Apical Periodontitis

Diseases in the Acute Apical Periodontitis family:

Chronic Apical Periodontitis

Diseases related to Chronic Apical Periodontitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 69)
# Related Disease Score Top Affiliating Genes
1 periodontitis 31.4 TNFSF11 TNFRSF11B IL1B
2 dental pulp necrosis 30.7 TNFSF11 SNRNP40
3 root resorption 30.1 TNFSF11 TNFRSF11B IL1B
4 periapical periodontitis 30.1 TNFSF11 TNFRSF11B OAF NFATC1 IL1B
5 bone resorption disease 30.1 TNFSF11 TNFRSF11B NFATC1
6 periodontitis, chronic 29.9 TNFSF11 TNFRSF11B IL1B
7 suppurative periapical periodontitis 29.9 OAF IL1B
8 polyarticular onset juvenile idiopathic arthritis 10.4 TNFSF11 TNFRSF11B
9 hemophilic arthropathy 10.4 TNFSF11 TNFRSF11B
10 paget disease of bone 5, juvenile-onset 10.4 TNFSF11 TNFRSF11B
11 multicentric reticulohistiocytosis 10.3 TNFSF11 TNFRSF11B
12 familial expansile osteolysis 10.3 TNFSF11 TNFRSF11B
13 riboflavin transporter deficiency neuronopathy 10.3 SLC52A3 SLC52A2
14 kummell's disease 10.3 TNFSF11 TNFRSF11B
15 madras motor neuron disease 10.3 SLC52A3 SLC52A2
16 multicentric carpotarsal osteolysis syndrome 10.3 TNFSF11 TNFRSF11B
17 brown-vialetto-van laere syndrome 1 10.3 SLC52A3 SLC52A2
18 brown-vialetto-van laere syndrome 10.3 SLC52A3 SLC52A2
19 tooth resorption 10.3 TNFSF11 TNFRSF11B
20 bone giant cell tumor 10.3 TNFSF11 TNFRSF11B
21 progressive bulbar palsy 10.3 SLC52A3 SLC52A2
22 pigmented villonodular synovitis 10.3 TNFSF11 TNFRSF11B
23 craniometaphyseal dysplasia, autosomal dominant 10.3 TNFSF11 TNFRSF11B
24 periapical granuloma 10.2
25 glucocorticoid-induced osteoporosis 10.2 TNFSF11 TNFRSF11B
26 cranial nerve palsy 10.2 SLC52A3 SLC52A2
27 van buchem disease 10.2 TNFSF11 TNFRSF11B
28 osteoporosis, juvenile 10.2 TNFSF11 TNFRSF11B
29 prosthetic joint infection 10.2 TNFRSF11B IL1B
30 renal osteodystrophy 10.2 TNFSF11 TNFRSF11B
31 parathyroid gland disease 10.2 TNFSF11 TNFRSF11B
32 idiopathic hypercalciuria 10.1 TNFSF11 IL1B
33 mammary paget's disease 10.1 TNFSF11 TNFRSF11B
34 chronic recurrent multifocal osteomyelitis 10.1 TNFSF11 IL1B
35 arteries, anomalies of 10.1
36 coronary heart disease 1 10.1
37 hyperlipoproteinemia, type iii 10.1
38 coronary artery anomaly 10.1
39 sclerosteosis 10.0 TNFSF11 TNFRSF11B
40 poems syndrome 10.0 TNFSF11 TNFRSF11B IL1B
41 gingival disease 10.0 TNFSF11 TNFRSF11B IL1B
42 aggressive periodontitis 10.0 TNFSF11 TNFRSF11B IL1B
43 arthropathy 10.0 TNFSF11 TNFRSF11B IL1B
44 mineral metabolism disease 10.0 TNFSF11 TNFRSF11B
45 synovitis 9.9 TNFSF11 TNFRSF11B IL1B
46 atherosclerosis susceptibility 9.9
47 triiodothyronine receptor auxiliary protein 9.9
48 fibroma 9.9
49 adenoid cystic carcinoma 9.9
50 osteomyelitis 9.9

Graphical network of the top 20 diseases related to Chronic Apical Periodontitis:



Diseases related to Chronic Apical Periodontitis

Symptoms & Phenotypes for Chronic Apical Periodontitis

MGI Mouse Phenotypes related to Chronic Apical Periodontitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 9.02 NFATC1 SLC52A2 SLC52A3 TNFRSF11B TNFSF11

Drugs & Therapeutics for Chronic Apical Periodontitis

Drugs for Chronic Apical Periodontitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Epinephrine Approved, Vet_approved 51-43-4 5816
2
Racepinephrine Approved 329-65-7 838
3 Pharmaceutical Solutions
4 Disinfectants
5 Anti-Infective Agents
6 Epinephryl borate
7
s 1 (combination)
8 Sodium hypochlorite Early Phase 1
9 Eusol Early Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Cytokine Regulation of Periradicular Pain in Humans Completed NCT00223470
2 Effects of Irrigation Activation on Clinical Outcomes of Root Canal Treatment in Posterior Teeth With Chronic Apical Periodontitis Completed NCT03990584
3 Measurement of Bite Force in Humans Completed NCT00223327
4 Longitudinal Endodontic Study of Apical Preparation Size Completed NCT00223379
5 Postoperative Pain After the Removal of Root Canal Filling Material Using Different Techniques in Teeth With Failed Root Canal Therapy: A Randomized Clinical Trial Completed NCT02905773 Early Phase 1
6 Effect of Diode Laser Disinfection on Postoperative Pain in Retreatment Cases Completed NCT03584880
7 Effect of Sodium Hypochlorite Concentration on Success of Non-surgical Root Canal Treatment: A Randomized Controlled Trial. Completed NCT03288467
8 Effect of Different Instrumentation Technique on Outcome of Primary Non Surgical Endodontic Treatment Completed NCT03278054
9 Effect of Passive Ultrasonic Irrigation on Success of Primary Endodontic Treatment Completed NCT02632513
10 Clinical Research of the Effects of Photodynamic Therapy and Bioceramic Filling of Root Canals on the Healing of Periapical Lesions and the Occurence of Postoperative Pain After Endodontic Retreatment Recruiting NCT04072926 Early Phase 1 BioRoot

Search NIH Clinical Center for Chronic Apical Periodontitis

Genetic Tests for Chronic Apical Periodontitis

Anatomical Context for Chronic Apical Periodontitis

MalaCards organs/tissues related to Chronic Apical Periodontitis:

40
Bone, Heart, Salivary Gland, Colon, Endothelial, Monocytes, Neutrophil

Publications for Chronic Apical Periodontitis

Articles related to Chronic Apical Periodontitis:

(show top 50) (show all 258)
# Title Authors PMID Year
1
WNT signalling pathway in oral lesions. 61
31740880 2019
2
Endodontic complications associated with orthodontic temporary anchorage devices: A systematic review of human studies. 61
31621999 2019
3
[Apical barrier technology to treat chronic apical periodontitis caused by type Ⅱ dens invaginatus: a case report]. 61
31721510 2019
4
Antibiotic prescribing for endodontic infections: a survey of dental students in Italy. 61
30982994 2019
5
Effects of alpha-lipoic acid therapy on experimentally induced apical periodontitis: a biochemical, histopathological and micro-CT analysis. 61
30900747 2019
6
Micro-CT analysis of chronic apical periodontitis induced by several specific pathogens. 61
30734930 2019
7
Role of interleukin-33 in the clinical pathogenesis of chronic apical periodontitis. 61
31218936 2019
8
East java extract propolis as potential intracanal medicament in experimentally induced chronic apical periodontitis. 61
31397405 2019
9
Endothelial Dysfunction Marker Variation in Young Adults with Chronic Apical Periodontitis before and after Endodontic Treatment. 61
30910354 2019
10
Inflammatory profile of chronic apical periodontitis: a literature review. 61
30585523 2019
11
Effect of Different Concentrations of Sodium Hypochlorite on Outcome of Primary Root Canal Treatment: A Randomized Controlled Trial. 61
30827769 2019
12
Association between C-reactive protein, neutrophil to lymphocyte ratio and the burden of apical periodontitis: a case-control study. 61
30394169 2019
13
Septic pulmonary embolism associated with periodontal disease: a case report and literature review. 61
30665352 2019
14
Endodontic Retreatment of Maxillary Second Molar with Four Roots. 61
31263606 2019
15
Non-surgical Removal of Dens Invaginatus in Maxillary Lateral Incisor Using CBCT: Two-year Follow-up Case Report. 61
31667354 2019
16
Serum Amyloid A Contributes to Chronic Apical Periodontitis via TLR2 and TLR4. 61
30189157 2019
17
Role of the Btk-PLCγ2 Signaling Pathway in the Bone Destruction of Apical Periodontitis. 61
31427888 2019
18
microRNA-146a and Hey2 form a mutual negative feedback loop to regulate the inflammatory response in chronic apical periodontitis. 61
30125982 2019
19
Lesions of endodontic origin: An emerging risk factor for coronary heart diseases. 61
30595303 2018
20
Six-Year Follow-Up of Immature Tooth Revascularization With Enamel Matrix Proteins. 61
30020797 2018
21
Maxillary second molar with four roots and five canals. 61
30895113 2018
22
Prevalence and progression of early childhood caries in Nis, Serbia. 61
29790782 2018
23
Increased Root Canal Endotoxin Levels are Associated with Chronic Apical Periodontitis, Increased Oxidative and Nitrosative Stress, Major Depression, Severity of Depression, and a Lowered Quality of Life. 61
28455694 2018
24
[Study on the incidence of lateral canals and sealing quality in the apical third roots of permanent teeth with failed endodontic treatments]. 61
29690694 2018
25
Antibiotic prescription for endodontic infections: a survey of Brazilian Endodontists. 61
28744872 2018
26
The Effect of Gaseous Ozone in Infected Root Canal. 61
29531611 2018
27
Comparative Characteristics of the Methods of Treatment of Chronic Periodontitis Using Antibacterial Photodynamic Therapy (Per One Visit) and Calasept Preparation. 61
29510847 2018
28
Dickkopf-1 may regulate bone coupling by attenuating wnt/β-catenin signaling in chronic apical periodontitis. 61
29216526 2018
29
[Efficiency of chronic apical periodontitis treatment with use of Granulotec endodontic sealer]. 61
30589425 2018
30
Expression of Osteoprotegrin and Osteoclast Level in Chronic Apical Periodontitis Induced with East Java Propolis Extract. 61
29692834 2018
31
Expression of matrix metalloproteinase-8 and matrix metalloproteinase-13 in mast cells of human periapical lesions. 61
31938366 2018
32
Correlation between the Periapical Index and Lesion Volume in Cone-beam Computed Tomography Images. 61
29707007 2018
33
Excessive heat-associated gingival necrosis: a case report. 61
28419470 2017
34
Relationship between cardiovascular disease and dental pathology. Systematic review. 61
28645686 2017
35
Assessment of C-reactive Proteins, Cytokines, and Plasma Protein Levels in Hypertensive Patients with Apical Periodontitis. 61
28621285 2017
36
Adenoid Cystic Carcinoma of Maxillary Sinus Misdiagnosed as Chronic Apical Periodontitis. 61
28236426 2017
37
Postoperative pain after the removal of root canal filling material using different techniques in teeth with failed root canal therapy: a randomized clinical trial. 61
28162017 2017
38
[Comparison of the differences in pain and the effect of ibuprofen in reducing endodontic flare-up after single-visit root canal therapy between Uyghur and Han patients with chronic apical periodontitis]. 61
28815256 2017
39
Oxidative stress in patients with endodontic pathologies. 61
28894386 2017
40
[Local immune and oxidative status in exacerbated chronic apical periodontitis]. 61
28617403 2017
41
Sirtuin 1 regulates matrix metalloproteinase-13 expression induced by Porphyromonas endodontalis lipopolysaccharide via targeting nuclear factor-κB in osteoblasts. 61
28473882 2017
42
Oxidative Stress in the Local and Systemic Events of Apical Periodontitis. 61
29163211 2017
43
Evaluation of the Role of Probiotics in Endodontic Treatment: A Preliminary Study. 61
28316949 2017
44
Association between apical periodontitis lesions and plasmatic levels of C-reactive protein, interleukin 6 and fibrinogen in hypertensive patients. 61
26499471 2016
45
Pain following foraminal enlargement in mandibular molars with necrosis and apical periodontitis: A randomized controlled trial. 61
26580483 2016
46
[Mechanism of TNF-α in bone defect of chronic apical periodontitis]. 61
27858062 2016
47
Dental care provided to sickle cell anemia patients stratified by age: A population-based study in Northeastern Brazil. 61
27403053 2016
48
Immediate, Non Submerged Root Analog Zirconia Implant in Single Rooted Tooth Replacement: Case Report with 2 years Follow Up. 61
27408451 2016
49
Cellular Profile and Expression of Immunologic Markers in Chronic Apical Periodontitis from HIV-infected Patients Undergoing Highly Active Antiretroviral Therapy. 61
27118467 2016
50
Effect of the quorum-sensing luxS gene on biofilm formation by Enterococcus faecalis. 61
27080421 2016

Variations for Chronic Apical Periodontitis

Expression for Chronic Apical Periodontitis

Search GEO for disease gene expression data for Chronic Apical Periodontitis.

Pathways for Chronic Apical Periodontitis

Pathways related to Chronic Apical Periodontitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.98 TNFSF11 TNFRSF11B NFATC1
2 11.03 TNFSF11 TNFRSF11B NFATC1 IL1B
3
Show member pathways
11 TNFRSF11B IL1B
4 10.8 TNFSF11 TNFRSF11B
5 10.79 TNFSF11 TNFRSF11B IL1B
6 10.46 TNFSF11 TNFRSF11B
7 10.3 TNFSF11 TNFRSF11B

GO Terms for Chronic Apical Periodontitis

Biological processes related to Chronic Apical Periodontitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 riboflavin metabolic process GO:0006771 8.96 SLC52A3 SLC52A2
2 riboflavin transport GO:0032218 8.62 SLC52A3 SLC52A2

Molecular functions related to Chronic Apical Periodontitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.13 TNFSF11 TNFRSF11B IL1B
2 riboflavin transmembrane transporter activity GO:0032217 8.62 SLC52A3 SLC52A2

Sources for Chronic Apical Periodontitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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