MCID: CHR013
MIFTS: 31

Chronic Apical Periodontitis

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Chronic Apical Periodontitis

MalaCards integrated aliases for Chronic Apical Periodontitis:

Name: Chronic Apical Periodontitis 12 15 72 33

Classifications:



External Ids:

Disease Ontology 12 DOID:11269
ICD9CM 35 522.6
SNOMED-CT 68 87782002
ICD10 33 K04.5
UMLS 72 C0392492

Summaries for Chronic Apical Periodontitis

MalaCards based summary : Chronic Apical Periodontitis is related to periodontitis and periapical periodontitis. An important gene associated with Chronic Apical Periodontitis is TNFRSF11B (TNF Receptor Superfamily Member 11b), and among its related pathways/superpathways are Osteoclast differentiation and Transcription_Role of VDR in regulation of genes involved in osteoporosis. The drugs Epinephrine and Racepinephrine have been mentioned in the context of this disorder. Affiliated tissues include bone, salivary gland and colon.

Related Diseases for Chronic Apical Periodontitis

Diseases in the Acute Apical Periodontitis family:

Chronic Apical Periodontitis

Diseases related to Chronic Apical Periodontitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)
# Related Disease Score Top Affiliating Genes
1 periodontitis 31.9 TNFSF11 TNFRSF11B
2 periapical periodontitis 31.4 TNFSF11 TNFRSF11B SASS6
3 bone resorption disease 30.7 TNFSF11 TNFRSF11B
4 root resorption 30.5 TNFSF11 TNFRSF11B
5 periodontitis, chronic 30.4 TNFSF11 TNFRSF11B
6 polyarticular onset juvenile idiopathic arthritis 10.3 TNFSF11 TNFRSF11B
7 hemophilic arthropathy 10.3 TNFSF11 TNFRSF11B
8 arthropathy 10.3 TNFSF11 TNFRSF11B
9 kummell's disease 10.3 TNFSF11 TNFRSF11B
10 multicentric reticulohistiocytosis 10.3 TNFSF11 TNFRSF11B
11 paget disease of bone 5, juvenile-onset 10.3 TNFSF11 TNFRSF11B
12 familial expansile osteolysis 10.3 TNFSF11 TNFRSF11B
13 multicentric carpotarsal osteolysis syndrome 10.3 TNFSF11 TNFRSF11B
14 tooth resorption 10.3 TNFSF11 TNFRSF11B
15 glucocorticoid-induced osteoporosis 10.3 TNFSF11 TNFRSF11B
16 ischemic bone disease 10.2 TNFSF11 TNFRSF11B
17 periapical granuloma 10.2
18 endosteal hyperostosis, autosomal dominant 10.2 TNFSF11 TNFRSF11B
19 bone remodeling disease 10.2 TNFSF11 TNFRSF11B
20 dental pulp necrosis 10.2
21 osteonecrosis 10.2 TNFSF11 TNFRSF11B
22 paget's disease of bone 10.1 TNFSF11 TNFRSF11B
23 bone inflammation disease 10.1 TNFSF11 TNFRSF11B
24 arteries, anomalies of 10.1
25 hyperlipoproteinemia, type iii 10.1
26 coronary artery anomaly 10.1
27 madras motor neuron disease 10.1 SLC52A3 SLC52A2
28 giant cell tumor 10.1 TNFSF11 TNFRSF11B
29 progressive bulbar palsy 10.0 SLC52A3 SLC52A2
30 aortic valve disease 2 10.0 TNFSF11 TNFRSF11B
31 brown-vialetto-van laere syndrome 10.0 SLC52A3 SLC52A2
32 atherosclerosis susceptibility 9.9
33 triiodothyronine receptor auxiliary protein 9.9
34 coronary heart disease 1 9.9
35 fibroma 9.9
36 adenoid cystic carcinoma 9.9
37 osteomyelitis 9.9
38 bacterial infectious disease 9.9
39 ossifying fibroma 9.9
40 suppurative periapical periodontitis 9.9
41 bronchitis 9.9
42 hard palate cancer 9.9
43 periostitis 9.9
44 paresthesia 9.9
45 synovitis 9.9 TNFSF11 TNFRSF11B
46 psoriatic arthritis 9.7 TNFSF11 TNFRSF11B

Graphical network of the top 20 diseases related to Chronic Apical Periodontitis:



Diseases related to Chronic Apical Periodontitis

Symptoms & Phenotypes for Chronic Apical Periodontitis

Drugs & Therapeutics for Chronic Apical Periodontitis

Drugs for Chronic Apical Periodontitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Epinephrine Approved, Vet_approved 51-43-4 5816
2
Racepinephrine Approved 329-65-7 838
3 Pharmaceutical Solutions
4 Sodium hypochlorite
5 Disinfectants
6 Anti-Infective Agents
7 Eusol
8
s 1 (combination)
9 Epinephryl borate

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Cytokine Regulation of Periradicular Pain in Humans Completed NCT00223470
2 Effects of Irrigation Activation on Clinical Outcomes of Root Canal Treatment in Posterior Teeth With Chronic Apical Periodontitis Completed NCT03990584
3 Measurement of Bite Force in Humans Completed NCT00223327
4 Longitudinal Endodontic Study of Apical Preparation Size Completed NCT00223379
5 Postoperative Pain After the Removal of Root Canal Filling Material Using Different Techniques in Teeth With Failed Root Canal Therapy: A Randomized Clinical Trial Completed NCT02905773 Early Phase 1
6 Effect of Diode Laser Disinfection on Postoperative Pain in Retreatment Cases Completed NCT03584880
7 Effect of Sodium Hypochlorite Concentration on Success of Non-surgical Root Canal Treatment: A Randomized Controlled Trial. Completed NCT03288467
8 Effect of Different Instrumentation Technique on Outcome of Primary Non Surgical Endodontic Treatment Completed NCT03278054
9 Effect of Passive Ultrasonic Irrigation on Success of Primary Endodontic Treatment Completed NCT02632513

Search NIH Clinical Center for Chronic Apical Periodontitis

Genetic Tests for Chronic Apical Periodontitis

Anatomical Context for Chronic Apical Periodontitis

MalaCards organs/tissues related to Chronic Apical Periodontitis:

41
Bone, Salivary Gland, Colon, Endothelial, Heart, Neutrophil, Monocytes

Publications for Chronic Apical Periodontitis

Articles related to Chronic Apical Periodontitis:

(show top 50) (show all 253)
# Title Authors PMID Year
1
Antibiotic prescribing for endodontic infections: a survey of dental students in Italy. 38
30982994 2019
2
Effects of alpha-lipoic acid therapy on experimentally induced apical periodontitis: a biochemical, histopathological and micro-CT analysis. 38
30900747 2019
3
Micro-CT analysis of chronic apical periodontitis induced by several specific pathogens. 38
30734930 2019
4
Role of interleukin-33 in the clinical pathogenesis of chronic apical periodontitis. 38
31218936 2019
5
East java extract propolis as potential intracanal medicament in experimentally induced chronic apical periodontitis. 38
31397405 2019
6
Endothelial Dysfunction Marker Variation in Young Adults with Chronic Apical Periodontitis before and after Endodontic Treatment. 38
30910354 2019
7
Inflammatory profile of chronic apical periodontitis: a literature review. 38
30585523 2019
8
Effect of Different Concentrations of Sodium Hypochlorite on Outcome of Primary Root Canal Treatment: A Randomized Controlled Trial. 38
30827769 2019
9
Association between C-reactive protein, neutrophil to lymphocyte ratio and the burden of apical periodontitis: a case-control study. 38
30394169 2019
10
Endodontic Retreatment of Maxillary Second Molar with Four Roots. 38
31263606 2019
11
Septic pulmonary embolism associated with periodontal disease: a case report and literature review. 38
30665352 2019
12
Serum Amyloid A Contributes to Chronic Apical Periodontitis via TLR2 and TLR4. 38
30189157 2019
13
Role of the Btk-PLCγ2 Signaling Pathway in the Bone Destruction of Apical Periodontitis. 38
31427888 2019
14
microRNA-146a and Hey2 form a mutual negative feedback loop to regulate the inflammatory response in chronic apical periodontitis. 38
30125982 2019
15
Lesions of endodontic origin: An emerging risk factor for coronary heart diseases. 38
30595303 2018
16
Six-Year Follow-Up of Immature Tooth Revascularization With Enamel Matrix Proteins. 38
30020797 2018
17
Maxillary second molar with four roots and five canals. 38
30895113 2018
18
Prevalence and progression of early childhood caries in Nis, Serbia. 38
29790782 2018
19
Increased Root Canal Endotoxin Levels are Associated with Chronic Apical Periodontitis, Increased Oxidative and Nitrosative Stress, Major Depression, Severity of Depression, and a Lowered Quality of Life. 38
28455694 2018
20
[Study on the incidence of lateral canals and sealing quality in the apical third roots of permanent teeth with failed endodontic treatments]. 38
29690694 2018
21
Antibiotic prescription for endodontic infections: a survey of Brazilian Endodontists. 38
28744872 2018
22
The Effect of Gaseous Ozone in Infected Root Canal. 38
29531611 2018
23
Comparative Characteristics of the Methods of Treatment of Chronic Periodontitis Using Antibacterial Photodynamic Therapy (Per One Visit) and Calasept Preparation. 38
29510847 2018
24
Dickkopf-1 may regulate bone coupling by attenuating wnt/β-catenin signaling in chronic apical periodontitis. 38
29216526 2018
25
[Efficiency of chronic apical periodontitis treatment with use of Granulotec endodontic sealer]. 38
30589425 2018
26
Expression of Osteoprotegrin and Osteoclast Level in Chronic Apical Periodontitis Induced with East Java Propolis Extract. 38
29692834 2018
27
Correlation between the Periapical Index and Lesion Volume in Cone-beam Computed Tomography Images. 38
29707007 2018
28
Excessive heat-associated gingival necrosis: a case report. 38
28419470 2017
29
Relationship between cardiovascular disease and dental pathology. Systematic review. 38
28645686 2017
30
Adenoid Cystic Carcinoma of Maxillary Sinus Misdiagnosed as Chronic Apical Periodontitis. 38
28236426 2017
31
Assessment of C-reactive Proteins, Cytokines, and Plasma Protein Levels in Hypertensive Patients with Apical Periodontitis. 38
28621285 2017
32
Postoperative pain after the removal of root canal filling material using different techniques in teeth with failed root canal therapy: a randomized clinical trial. 38
28162017 2017
33
[Comparison of the differences in pain and the effect of ibuprofen in reducing endodontic flare-up after single-visit root canal therapy between Uyghur and Han patients with chronic apical periodontitis]. 38
28815256 2017
34
Sirtuin 1 regulates matrix metalloproteinase-13 expression induced by Porphyromonas endodontalis lipopolysaccharide via targeting nuclear factor-κB in osteoblasts. 38
28473882 2017
35
Oxidative stress in patients with endodontic pathologies. 38
28894386 2017
36
[Local immune and oxidative status in exacerbated chronic apical periodontitis]. 38
28617403 2017
37
Oxidative Stress in the Local and Systemic Events of Apical Periodontitis. 38
29163211 2017
38
Evaluation of the Role of Probiotics in Endodontic Treatment: A Preliminary Study. 38
28316949 2017
39
Association between apical periodontitis lesions and plasmatic levels of C-reactive protein, interleukin 6 and fibrinogen in hypertensive patients. 38
26499471 2016
40
Pain following foraminal enlargement in mandibular molars with necrosis and apical periodontitis: A randomized controlled trial. 38
26580483 2016
41
[Mechanism of TNF-α in bone defect of chronic apical periodontitis]. 38
27858062 2016
42
Dental care provided to sickle cell anemia patients stratified by age: A population-based study in Northeastern Brazil. 38
27403053 2016
43
Immediate, Non Submerged Root Analog Zirconia Implant in Single Rooted Tooth Replacement: Case Report with 2 years Follow Up. 38
27408451 2016
44
Cellular Profile and Expression of Immunologic Markers in Chronic Apical Periodontitis from HIV-infected Patients Undergoing Highly Active Antiretroviral Therapy. 38
27118467 2016
45
Effect of the quorum-sensing luxS gene on biofilm formation by Enterococcus faecalis. 38
27080421 2016
46
A retrospective study of 51,781 adult oral and maxillofacial biopsies. 38
26562725 2016
47
[Expression of IL-34 in chronic periapical lesions and its clinical significance]. 38
27063309 2016
48
Clinical, imagistic and histopathological study of chronic apical periodontitis. 38
27833964 2016
49
[The use of self-adapting system files (SAF) for controlling microbial biofilms of root canals in the treatment of apical periodontitis]. 38
28139587 2016
50
Dental Pulp Revascularization of Necrotic Permanent Teeth with Immature Apices. 38
27617376 2016

Variations for Chronic Apical Periodontitis

Expression for Chronic Apical Periodontitis

Search GEO for disease gene expression data for Chronic Apical Periodontitis.

Pathways for Chronic Apical Periodontitis

Pathways related to Chronic Apical Periodontitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.43 TNFSF11 TNFRSF11B
2 10.91 TNFSF11 TNFRSF11B
3 10.63 TNFSF11 TNFRSF11B
4 10.16 TNFSF11 TNFRSF11B
5 9.77 TNFSF11 TNFRSF11B

GO Terms for Chronic Apical Periodontitis

Biological processes related to Chronic Apical Periodontitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tumor necrosis factor-mediated signaling pathway GO:0033209 9.16 TNFSF11 TNFRSF11B
2 riboflavin metabolic process GO:0006771 8.96 SLC52A3 SLC52A2
3 riboflavin transport GO:0032218 8.62 SLC52A3 SLC52A2

Molecular functions related to Chronic Apical Periodontitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.13 TNFSF11 TNFRSF11B IL34
2 riboflavin transmembrane transporter activity GO:0032217 8.62 SLC52A3 SLC52A2

Sources for Chronic Apical Periodontitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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