MCID: CHR013
MIFTS: 31

Chronic Apical Periodontitis

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Chronic Apical Periodontitis

MalaCards integrated aliases for Chronic Apical Periodontitis:

Name: Chronic Apical Periodontitis 12 15 71 32

Classifications:



External Ids:

Disease Ontology 12 DOID:11269
ICD9CM 34 522.6
SNOMED-CT 67 718052004
ICD10 32 K04.5
UMLS 71 C0392492

Summaries for Chronic Apical Periodontitis

MalaCards based summary : Chronic Apical Periodontitis is related to periodontitis and periapical periodontitis. An important gene associated with Chronic Apical Periodontitis is TNFRSF11B (TNF Receptor Superfamily Member 11b), and among its related pathways/superpathways are Transcription_Role of VDR in regulation of genes involved in osteoporosis and Osteoclast Signaling. The drugs Silicon and Anti-Bacterial Agents have been mentioned in the context of this disorder. Affiliated tissues include bone, salivary gland and colon.

Related Diseases for Chronic Apical Periodontitis

Diseases in the Acute Apical Periodontitis family:

Chronic Apical Periodontitis

Diseases related to Chronic Apical Periodontitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Related Disease Score Top Affiliating Genes
1 periodontitis 31.6 TNFSF11 TNFRSF11B MIR146A
2 periapical periodontitis 31.3 TNFSF11 TNFRSF11B OAF
3 dental pulp necrosis 30.6 TNFSF11 SNRNP40
4 root resorption 30.5 TNFSF11 TNFRSF11B
5 periodontitis, chronic 30.5 TNFSF11 TNFRSF11B
6 polyarticular onset juvenile idiopathic arthritis 10.4 TNFSF11 TNFRSF11B
7 hemophilic arthropathy 10.4 TNFSF11 TNFRSF11B
8 paget disease of bone 5, juvenile-onset 10.4 TNFSF11 TNFRSF11B
9 multicentric reticulohistiocytosis 10.4 TNFSF11 TNFRSF11B
10 disseminated chorioretinitis 10.4 TNFSF11 TNFRSF11B
11 kummell's disease 10.3 TNFSF11 TNFRSF11B
12 tooth resorption 10.3 TNFSF11 TNFRSF11B
13 poems syndrome 10.3 TNFSF11 TNFRSF11B
14 multicentric carpotarsal osteolysis syndrome 10.3 TNFSF11 TNFRSF11B
15 pigmented villonodular synovitis 10.3 TNFSF11 TNFRSF11B
16 hajdu-cheney syndrome 10.3 TNFSF11 HEY2
17 bone giant cell tumor 10.3 TNFSF11 TNFRSF11B
18 gingival disease 10.3 TNFSF11 TNFRSF11B
19 bone resorption disease 10.3
20 glucocorticoid-induced osteoporosis 10.3 TNFSF11 TNFRSF11B
21 osteoporosis, juvenile 10.3 TNFSF11 TNFRSF11B
22 van buchem disease 10.3 TNFSF11 TNFRSF11B
23 periapical granuloma 10.2
24 ischemic bone disease 10.2 TNFSF11 TNFRSF11B
25 mammary paget's disease 10.2 TNFSF11 TNFRSF11B
26 renal osteodystrophy 10.2 TNFSF11 TNFRSF11B
27 madras motor neuron disease 10.2 SLC52A3 SLC52A2
28 brown-vialetto-van laere syndrome 2 10.2 SLC52A3 SLC52A2
29 brown-vialetto-van laere syndrome 10.2 SLC52A3 SLC52A2
30 sclerosteosis 10.2 TNFSF11 TNFRSF11B
31 brown-vialetto-van laere syndrome 1 10.2 SLC52A3 SLC52A2
32 progressive bulbar palsy 10.2 SLC52A3 SLC52A2
33 benign giant cell tumor 10.2 TNFSF11 TNFRSF11B
34 fazio-londe disease 10.2 SLC52A3 SLC52A2
35 cranial nerve palsy 10.2 SLC52A3 SLC52A2
36 parathyroid gland disease 10.1 TNFSF11 TNFRSF11B
37 fibrous dysplasia 10.1 TNFSF11 TNFRSF11B
38 riboflavin deficiency 10.1 SLC52A3 SLC52A2
39 bone inflammation disease 10.1 TNFSF11 TNFRSF11B MIR146A
40 arteries, anomalies of 10.1
41 coronary heart disease 1 10.1
42 hyperlipoproteinemia, type iii 10.1
43 lipoprotein quantitative trait locus 10.1
44 psoriatic arthritis 10.1 TNFSF11 TNFRSF11B MIR146A
45 ankylosis 10.1 TNFSF11 TNFRSF11B
46 familial expansile osteolysis 10.0 TNFSF11 TNFRSF11B SNRNP40
47 aggressive periodontitis 10.0 TNFSF11 TNFRSF11B
48 motor neuron disease 9.9 SLC52A3 SLC52A2 MIR146A
49 atherosclerosis susceptibility 9.9
50 triiodothyronine receptor auxiliary protein 9.9

Graphical network of the top 20 diseases related to Chronic Apical Periodontitis:



Diseases related to Chronic Apical Periodontitis

Symptoms & Phenotypes for Chronic Apical Periodontitis

Drugs & Therapeutics for Chronic Apical Periodontitis

Drugs for Chronic Apical Periodontitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Silicon Approved, Investigational Phase 2, Phase 3 7440-21-3 4082203
2 Anti-Bacterial Agents Phase 2, Phase 3
3 Anti-Infective Agents Phase 2, Phase 3
4 Calcium, Dietary Phase 2, Phase 3
5
Calcium Nutraceutical Phase 2, Phase 3 7440-70-2 271
6
Epinephrine Approved, Vet_approved 51-43-4 5816
7
Racepinephrine Approved 329-65-7 838
8 Pharmaceutical Solutions
9 Epinephryl borate
10 Eusol Early Phase 1
11 Sodium hypochlorite Early Phase 1

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Comparison of Anti-microbial Efficacy of Calcipex and Metapex in Endodontic Treatment of Chronic Apical Periodontitis Not yet recruiting NCT04336709 Phase 2, Phase 3 Calcipex II;Metapex
2 Cytokine Regulation of Periradicular Pain in Humans Completed NCT00223470
3 Effects of Irrigation Activation on Clinical Outcomes of Root Canal Treatment in Posterior Teeth With Chronic Apical Periodontitis Completed NCT03990584
4 Measurement of Bite Force in Humans Completed NCT00223327
5 Longitudinal Endodontic Study of Apical Preparation Size Completed NCT00223379
6 Postoperative Pain After the Removal of Root Canal Filling Material Using Different Techniques in Teeth With Failed Root Canal Therapy: A Randomized Clinical Trial Completed NCT02905773 Early Phase 1
7 Effect of Diode Laser Disinfection on Postoperative Pain in Retreatment Cases Completed NCT03584880
8 Effect of Sodium Hypochlorite Concentration on Success of Non-surgical Root Canal Treatment: A Randomized Controlled Trial. Completed NCT03288467
9 Effect of Different Instrumentation Technique on Outcome of Primary Non Surgical Endodontic Treatment Completed NCT03278054
10 Effect of Passive Ultrasonic Irrigation on Success of Primary Endodontic Treatment Completed NCT02632513
11 A Cone Beam Computed Tomographic Evaluation of Healing of Apicomarginal Defects Using Autologous Platelet Aggregates : A Randomized Controlled Trial Recruiting NCT04389346
12 Clinical Research of the Effects of Photodynamic Therapy and Bioceramic Filling of Root Canals on the Healing of Periapical Lesions and the Occurence of Postoperative Pain After Endodontic Retreatment Recruiting NCT04072926 Early Phase 1 BioRoot

Search NIH Clinical Center for Chronic Apical Periodontitis

Genetic Tests for Chronic Apical Periodontitis

Anatomical Context for Chronic Apical Periodontitis

MalaCards organs/tissues related to Chronic Apical Periodontitis:

40
Bone, Salivary Gland, Colon, Endothelial, Heart, Monocytes, Neutrophil

Publications for Chronic Apical Periodontitis

Articles related to Chronic Apical Periodontitis:

(show top 50) (show all 266)
# Title Authors PMID Year
1
Determination of the Role of Fusobacterium Nucleatum in the Pathogenesis in and Out the Mouth. 61
32573481 2020
2
Immunoexpression of bone resorption biomarkers in apical periodontitis in diabetics and normoglycaemics. 61
32271943 2020
3
Endodontic complications associated with orthodontic temporary anchorage devices: A systematic review of human studies. 61
31621999 2020
4
Clinical, radiographic, and histological findings of chronic inflammatory periapical lesions - A clinical study. 61
32110596 2020
5
Technical note: surgical guide for computer-aided endodontic surgery. 61
32064851 2020
6
[Experimental study of the effectiveness of local anesthetic activity of a new dimethylphenylacetamide-containing pharmaceutical composition in chronic periodontitis]. 61
32441069 2020
7
[Morphology of root dentine in teeth extracted because of chronic apical periodontitis in various irrigation protocols]. 61
32441068 2020
8
WNT signalling pathway in oral lesions. 61
31740880 2019
9
[Apical barrier technology to treat chronic apical periodontitis caused by type Ⅱ dens invaginatus: a case report]. 61
31721510 2019
10
Antibiotic prescribing for endodontic infections: a survey of dental students in Italy. 61
30982994 2019
11
Effects of alpha-lipoic acid therapy on experimentally induced apical periodontitis: a biochemical, histopathological and micro-CT analysis. 61
30900747 2019
12
Micro-CT analysis of chronic apical periodontitis induced by several specific pathogens. 61
30734930 2019
13
Role of interleukin-33 in the clinical pathogenesis of chronic apical periodontitis. 61
31218936 2019
14
East java extract propolis as potential intracanal medicament in experimentally induced chronic apical periodontitis. 61
31397405 2019
15
Endothelial Dysfunction Marker Variation in Young Adults with Chronic Apical Periodontitis before and after Endodontic Treatment. 61
30910354 2019
16
Inflammatory profile of chronic apical periodontitis: a literature review. 61
30585523 2019
17
Comparative Evaluation of Triple Antibiotic Paste, Propolis with Moxifloxacin, and Calcium Hydroxide as Intracanal Medicaments against Streptococcus spp. and Enterococcus faecalis in Type II Diabetes Mellitus Patients: A Randomized Clinical Trial. 61
32308276 2019
18
Effect of Different Concentrations of Sodium Hypochlorite on Outcome of Primary Root Canal Treatment: A Randomized Controlled Trial. 61
30827769 2019
19
Association between C-reactive protein, neutrophil to lymphocyte ratio and the burden of apical periodontitis: a case-control study. 61
30394169 2019
20
Septic pulmonary embolism associated with periodontal disease: a case report and literature review. 61
30665352 2019
21
Endodontic Retreatment of Maxillary Second Molar with Four Roots. 61
31263606 2019
22
Non-surgical Removal of Dens Invaginatus in Maxillary Lateral Incisor Using CBCT: Two-year Follow-up Case Report. 61
31667354 2019
23
CAMPANELLIProgrammed Death 1 (PD-1) and PD-1 Ligand (PD-L1) Expression in Chronic Apical Periodontitis. 61
32161879 2019
24
microRNA-146a and Hey2 form a mutual negative feedback loop to regulate the inflammatory response in chronic apical periodontitis. 61
30125982 2019
25
Role of the Btk-PLCγ2 Signaling Pathway in the Bone Destruction of Apical Periodontitis. 61
31427888 2019
26
Serum Amyloid A Contributes to Chronic Apical Periodontitis via TLR2 and TLR4. 61
30189157 2019
27
Lesions of endodontic origin: An emerging risk factor for coronary heart diseases. 61
30595303 2018
28
Six-Year Follow-Up of Immature Tooth Revascularization With Enamel Matrix Proteins. 61
30020797 2018
29
Prevalence and progression of early childhood caries in Nis, Serbia. 61
29790782 2018
30
Maxillary second molar with four roots and five canals. 61
30895113 2018
31
Increased Root Canal Endotoxin Levels are Associated with Chronic Apical Periodontitis, Increased Oxidative and Nitrosative Stress, Major Depression, Severity of Depression, and a Lowered Quality of Life. 61
28455694 2018
32
[Study on the incidence of lateral canals and sealing quality in the apical third roots of permanent teeth with failed endodontic treatments]. 61
29690694 2018
33
Antibiotic prescription for endodontic infections: a survey of Brazilian Endodontists. 61
28744872 2018
34
The Effect of Gaseous Ozone in Infected Root Canal. 61
29531611 2018
35
Comparative Characteristics of the Methods of Treatment of Chronic Periodontitis Using Antibacterial Photodynamic Therapy (Per One Visit) and Calasept Preparation. 61
29510847 2018
36
Dickkopf-1 may regulate bone coupling by attenuating wnt/β-catenin signaling in chronic apical periodontitis. 61
29216526 2018
37
[Efficiency of chronic apical periodontitis treatment with use of Granulotec endodontic sealer]. 61
30589425 2018
38
Expression of Osteoprotegrin and Osteoclast Level in Chronic Apical Periodontitis Induced with East Java Propolis Extract. 61
29692834 2018
39
Correlation between the Periapical Index and Lesion Volume in Cone-beam Computed Tomography Images. 61
29707007 2018
40
Expression of matrix metalloproteinase-8 and matrix metalloproteinase-13 in mast cells of human periapical lesions. 61
31938366 2018
41
Relationship between cardiovascular disease and dental pathology. Systematic review. 61
28645686 2017
42
Excessive heat-associated gingival necrosis: a case report. 61
28419470 2017
43
Assessment of C-reactive Proteins, Cytokines, and Plasma Protein Levels in Hypertensive Patients with Apical Periodontitis. 61
28621285 2017
44
Adenoid Cystic Carcinoma of Maxillary Sinus Misdiagnosed as Chronic Apical Periodontitis. 61
28236426 2017
45
Postoperative pain after the removal of root canal filling material using different techniques in teeth with failed root canal therapy: a randomized clinical trial. 61
28162017 2017
46
[Comparison of the differences in pain and the effect of ibuprofen in reducing endodontic flare-up after single-visit root canal therapy between Uyghur and Han patients with chronic apical periodontitis]. 61
28815256 2017
47
[Local immune and oxidative status in exacerbated chronic apical periodontitis]. 61
28617403 2017
48
Oxidative stress in patients with endodontic pathologies. 61
28894386 2017
49
Sirtuin 1 regulates matrix metalloproteinase-13 expression induced by Porphyromonas endodontalis lipopolysaccharide via targeting nuclear factor-κB in osteoblasts. 61
28473882 2017
50
Oxidative Stress in the Local and Systemic Events of Apical Periodontitis. 61
29163211 2017

Variations for Chronic Apical Periodontitis

Expression for Chronic Apical Periodontitis

Search GEO for disease gene expression data for Chronic Apical Periodontitis.

Pathways for Chronic Apical Periodontitis

Pathways related to Chronic Apical Periodontitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.81 TNFSF11 TNFRSF11B
2 10.16 TNFSF11 TNFRSF11B
3 9.77 TNFSF11 TNFRSF11B

GO Terms for Chronic Apical Periodontitis

Biological processes related to Chronic Apical Periodontitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 microglial cell proliferation GO:0061518 9.26 IL34 IL33
2 riboflavin metabolic process GO:0006771 9.16 SLC52A3 SLC52A2
3 positive regulation of gene expression GO:0010628 9.02 TNFSF11 MIR146A IL34 IL33 HEY2
4 riboflavin transport GO:0032218 8.96 SLC52A3 SLC52A2

Molecular functions related to Chronic Apical Periodontitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.26 TNFSF11 TNFRSF11B IL34 IL33
2 riboflavin transmembrane transporter activity GO:0032217 8.62 SLC52A3 SLC52A2

Sources for Chronic Apical Periodontitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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