MCID: CHR013
MIFTS: 30

Chronic Apical Periodontitis

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Chronic Apical Periodontitis

MalaCards integrated aliases for Chronic Apical Periodontitis:

Name: Chronic Apical Periodontitis 12 15 71 32

Classifications:



External Ids:

Disease Ontology 12 DOID:11269
ICD9CM 34 522.6
SNOMED-CT 67 718052004
ICD10 32 K04.5
UMLS 71 C0392492

Summaries for Chronic Apical Periodontitis

MalaCards based summary : Chronic Apical Periodontitis is related to root resorption and periodontitis, chronic. An important gene associated with Chronic Apical Periodontitis is TNFSF11 (TNF Superfamily Member 11), and among its related pathways/superpathways are Transcription_Role of VDR in regulation of genes involved in osteoporosis and Osteoclast Signaling. The drugs Thrombin and Silicon have been mentioned in the context of this disorder. Affiliated tissues include endothelial, heart and neutrophil, and related phenotype is mortality/aging.

Related Diseases for Chronic Apical Periodontitis

Diseases in the Acute Apical Periodontitis family:

Chronic Apical Periodontitis

Diseases related to Chronic Apical Periodontitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 49)
# Related Disease Score Top Affiliating Genes
1 root resorption 30.5 TNFSF11 TNFRSF11B
2 periodontitis, chronic 30.3 TNFSF11 TNFRSF11B
3 periodontitis 11.0
4 periapical periodontitis 10.6
5 bone resorption disease 10.3
6 dental pulp necrosis 10.3
7 periapical granuloma 10.3
8 polyarticular onset juvenile idiopathic arthritis 10.2 TNFSF11 TNFRSF11B
9 hajdu-cheney syndrome 10.2 TNFSF11 HEY2
10 hemophilic arthropathy 10.2 TNFSF11 TNFRSF11B
11 disseminated chorioretinitis 10.2 TNFSF11 TNFRSF11B
12 paget disease of bone 5, juvenile-onset 10.2 TNFSF11 TNFRSF11B
13 multicentric reticulohistiocytosis 10.2 TNFSF11 TNFRSF11B
14 arteries, anomalies of 10.1
15 coronary heart disease 1 10.1
16 lipoprotein quantitative trait locus 10.1
17 multicentric carpotarsal osteolysis syndrome 10.1 TNFSF11 TNFRSF11B
18 craniometaphyseal dysplasia, autosomal dominant 10.1 TNFSF11 TNFRSF11B
19 familial expansile osteolysis 10.1 TNFSF11 TNFRSF11B
20 glucocorticoid-induced osteoporosis 10.1 TNFSF11 TNFRSF11B
21 benign giant cell tumor 10.1 TNFSF11 TNFRSF11B
22 renal osteodystrophy 10.1 TNFSF11 TNFRSF11B
23 madras motor neuron disease 10.0 SLC52A3 SLC52A2
24 mammary paget's disease 10.0 TNFSF11 TNFRSF11B
25 brown-vialetto-van laere syndrome 2 10.0 SLC52A3 SLC52A2
26 brown-vialetto-van laere syndrome 10.0 SLC52A3 SLC52A2
27 ankylosis 10.0 TNFSF11 TNFRSF11B
28 brown-vialetto-van laere syndrome 1 10.0 SLC52A3 SLC52A2
29 progressive bulbar palsy 10.0 SLC52A3 SLC52A2
30 cranial nerve palsy 10.0 SLC52A3 SLC52A2
31 atherosclerosis susceptibility 10.0
32 triiodothyronine receptor auxiliary protein 10.0
33 fibroma 10.0
34 adenoid cystic carcinoma 10.0
35 osteomyelitis 10.0
36 bacterial infectious disease 10.0
37 ossifying fibroma 10.0
38 suppurative periapical periodontitis 10.0
39 bronchitis 10.0
40 periostitis 10.0
41 47,xyy 10.0
42 depression 10.0
43 paresthesia 10.0
44 fazio-londe disease 10.0 SLC52A3 SLC52A2
45 osteonecrosis 10.0 TNFSF11 TNFRSF11B
46 riboflavin deficiency 10.0 SLC52A3 SLC52A2
47 motor neuron disease 9.8 SLC52A3 SLC52A2 MIR146A
48 spondyloarthropathy 1 9.8 TNFSF11 TNFRSF11B
49 multiple acyl-coa dehydrogenase deficiency 9.8 SLC52A3 SLC52A2

Graphical network of the top 20 diseases related to Chronic Apical Periodontitis:



Diseases related to Chronic Apical Periodontitis

Symptoms & Phenotypes for Chronic Apical Periodontitis

MGI Mouse Phenotypes related to Chronic Apical Periodontitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.23 HEY2 IL33 IL34 SLC52A2 SLC52A3 TNFRSF11B

Drugs & Therapeutics for Chronic Apical Periodontitis

Drugs for Chronic Apical Periodontitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Thrombin Approved, Investigational Phase 2, Phase 3
2
Silicon Approved, Investigational Phase 2, Phase 3 7440-21-3 4082203
3 Anti-Infective Agents Phase 2, Phase 3
4 Anti-Bacterial Agents Phase 2, Phase 3
5 Calcium, Dietary Phase 2, Phase 3
6
Calcium Nutraceutical Phase 2, Phase 3 7440-70-2 271

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Transplantation of Allogeneic Mesenchymal Stromal Cells in Patients With Immature Apex Teeth With Pulp Necrosis and Chronic Apical Periodontitis Completed NCT04545307 Phase 2, Phase 3
2 Comparison of Anti-microbial Efficacy of Calcipex and Metapex in Endodontic Treatment of Chronic Apical Periodontitis Recruiting NCT04336709 Phase 2, Phase 3 Calcipex II;Metapex
3 Longitudinal Endodontic Study of Apical Preparation Size Completed NCT00223379
4 Cytokine Regulation of Periradicular Pain in Humans Completed NCT00223470
5 Effects of Irrigation Activation on Clinical Outcomes of Root Canal Treatment in Posterior Teeth With Chronic Apical Periodontitis Completed NCT03990584
6 A Cone Beam Computed Tomographic Evaluation of Healing of Apicomarginal Defects Using Autologous Platelet Aggregates : A Randomized Controlled Trial Recruiting NCT04389346

Search NIH Clinical Center for Chronic Apical Periodontitis

Genetic Tests for Chronic Apical Periodontitis

Anatomical Context for Chronic Apical Periodontitis

MalaCards organs/tissues related to Chronic Apical Periodontitis:

40
Endothelial, Heart, Neutrophil

Publications for Chronic Apical Periodontitis

Articles related to Chronic Apical Periodontitis:

(show top 50) (show all 280)
# Title Authors PMID Year
1
Palatal root surgery of a maxillary molar using a piezosurgery transantral approach with simultaneous sinus lift grafting: a case report. 61
33012051 2021
2
Idiopathic Bone Cavity: Clinicopathologic Features from a Case Series with Emphasis on Differential Diagnosis of Chronic Apical Periodontitis. 61
33217470 2021
3
Immunoexpression Of Il-17, Il-6 And Il-1β In Primary Chronic Apical Periodontitis In Smokers And Non-Smokers. 61
33548327 2021
4
Effects of chronic apical periodontitis on the inflammatory response of the aorta in hyperlipemic rats. 61
33404761 2021
5
Wnt antagonist secreted frizzled-related protein I (sFRP1) may be involved in the osteogenic differentiation of periodontal ligament cells in chronic apical periodontitis. 61
33290588 2020
6
Expression of Inflammatory Markers RANK, MMP-9 and PTHrP in Chronic Apical Periodontitis from People Living with HIV Undergoing Antiretroviral Therapy. 61
33182451 2020
7
Effect of using diode laser on Enterococcus faecalis and its lipoteichoic acid (LTA) in chronic apical periodontitis. 61
32965611 2020
8
A randomized controlled trial of endodontic treatment using ultrasonic irrigation and laser activated irrigation to evaluate healing in chronic apical periodontitis. 61
32994870 2020
9
Immunoexpression of bone resorption biomarkers in apical periodontitis in diabetics and normoglycaemics. 61
32271943 2020
10
Endodontic approach in a replanted tooth with an immature root apex and chronic apical periodontitis: a case report. 61
32839710 2020
11
miR-200a contributes to the migration of BMSCs induced by the secretions of E. faecalis via FOXJ1/NFκB/MMPs axis. 61
32711573 2020
12
Non-surgical management of an extraoral cutaneous sinus tract of odontogenic origin. 61
32690568 2020
13
Comparative Analysis of the Proteomic Profile of the Dental Pulp in Different Conditions. A Pilot Study. 61
32667518 2020
14
Determination of the Role of Fusobacterium Nucleatum in the Pathogenesis in and Out the Mouth. 61
32573481 2020
15
The Role of the Immune Response in Chronic Marginal and Apical Periodontitis. 61
32666754 2020
16
Endodontic complications associated with orthodontic temporary anchorage devices: A systematic review of human studies. 61
31621999 2020
17
Technical note: surgical guide for computer-aided endodontic surgery. 61
32064851 2020
18
[Experimental study of the effectiveness of local anesthetic activity of a new dimethylphenylacetamide-containing pharmaceutical composition in chronic periodontitis]. 61
32441069 2020
19
Clinical and microbiological assessment of root canal decontamination in chronic apical periodontitis using the ultrasound. 61
32723937 2020
20
Clinical, radiographic, and histological findings of chronic inflammatory periapical lesions - A clinical study. 61
32110596 2020
21
[Morphology of root dentine in teeth extracted because of chronic apical periodontitis in various irrigation protocols]. 61
32441068 2020
22
WNT signalling pathway in oral lesions. 61
31740880 2019
23
[Apical barrier technology to treat chronic apical periodontitis caused by type Ⅱ dens invaginatus: a case report]. 61
31721510 2019
24
Effects of alpha-lipoic acid therapy on experimentally induced apical periodontitis: a biochemical, histopathological and micro-CT analysis. 61
30900747 2019
25
Antibiotic prescribing for endodontic infections: a survey of dental students in Italy. 61
30982994 2019
26
Micro-CT analysis of chronic apical periodontitis induced by several specific pathogens. 61
30734930 2019
27
Role of interleukin-33 in the clinical pathogenesis of chronic apical periodontitis. 61
31218936 2019
28
East java extract propolis as potential intracanal medicament in experimentally induced chronic apical periodontitis. 61
31397405 2019
29
Endothelial Dysfunction Marker Variation in Young Adults with Chronic Apical Periodontitis before and after Endodontic Treatment. 61
30910354 2019
30
Inflammatory profile of chronic apical periodontitis: a literature review. 61
30585523 2019
31
Comparative Evaluation of Triple Antibiotic Paste, Propolis with Moxifloxacin, and Calcium Hydroxide as Intracanal Medicaments against Streptococcus spp. and Enterococcus faecalis in Type II Diabetes Mellitus Patients: A Randomized Clinical Trial. 61
32308276 2019
32
Effect of Different Concentrations of Sodium Hypochlorite on Outcome of Primary Root Canal Treatment: A Randomized Controlled Trial. 61
30827769 2019
33
Association between C-reactive protein, neutrophil to lymphocyte ratio and the burden of apical periodontitis: a case-control study. 61
30394169 2019
34
Endodontic Retreatment of Maxillary Second Molar with Four Roots. 61
31263606 2019
35
Septic pulmonary embolism associated with periodontal disease: a case report and literature review. 61
30665352 2019
36
Non-surgical Removal of Dens Invaginatus in Maxillary Lateral Incisor Using CBCT: Two-year Follow-up Case Report. 61
31667354 2019
37
microRNA-146a and Hey2 form a mutual negative feedback loop to regulate the inflammatory response in chronic apical periodontitis. 61
30125982 2019
38
CAMPANELLIProgrammed Death 1 (PD-1) and PD-1 Ligand (PD-L1) Expression in Chronic Apical Periodontitis. 61
32161879 2019
39
Serum Amyloid A Contributes to Chronic Apical Periodontitis via TLR2 and TLR4. 61
30189157 2019
40
Role of the Btk-PLCγ2 Signaling Pathway in the Bone Destruction of Apical Periodontitis. 61
31427888 2019
41
Lesions of endodontic origin: An emerging risk factor for coronary heart diseases. 61
30595303 2018
42
Six-Year Follow-Up of Immature Tooth Revascularization With Enamel Matrix Proteins. 61
30020797 2018
43
Maxillary second molar with four roots and five canals. 61
30895113 2018
44
Prevalence and progression of early childhood caries in Nis, Serbia. 61
29790782 2018
45
Increased Root Canal Endotoxin Levels are Associated with Chronic Apical Periodontitis, Increased Oxidative and Nitrosative Stress, Major Depression, Severity of Depression, and a Lowered Quality of Life. 61
28455694 2018
46
[Study on the incidence of lateral canals and sealing quality in the apical third roots of permanent teeth with failed endodontic treatments]. 61
29690694 2018
47
Comparative Characteristics of the Methods of Treatment of Chronic Periodontitis Using Antibacterial Photodynamic Therapy (Per One Visit) and Calasept Preparation. 61
29510847 2018
48
The Effect of Gaseous Ozone in Infected Root Canal. 61
29531611 2018
49
Antibiotic prescription for endodontic infections: a survey of Brazilian Endodontists. 61
28744872 2018
50
Dickkopf-1 may regulate bone coupling by attenuating wnt/β-catenin signaling in chronic apical periodontitis. 61
29216526 2018

Variations for Chronic Apical Periodontitis

Expression for Chronic Apical Periodontitis

Search GEO for disease gene expression data for Chronic Apical Periodontitis.

Pathways for Chronic Apical Periodontitis

Pathways related to Chronic Apical Periodontitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.81 TNFSF11 TNFRSF11B
2 10.16 TNFSF11 TNFRSF11B
3 9.77 TNFSF11 TNFRSF11B

GO Terms for Chronic Apical Periodontitis

Biological processes related to Chronic Apical Periodontitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of MAP kinase activity GO:0043406 9.32 TNFSF11 IL34
2 microglial cell proliferation GO:0061518 9.26 IL34 IL33
3 riboflavin metabolic process GO:0006771 9.16 SLC52A3 SLC52A2
4 positive regulation of gene expression GO:0010628 9.02 TNFSF11 MIR146A IL34 IL33 HEY2
5 riboflavin transport GO:0032218 8.96 SLC52A3 SLC52A2

Molecular functions related to Chronic Apical Periodontitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 riboflavin transmembrane transporter activity GO:0032217 8.96 SLC52A3 SLC52A2
2 cytokine activity GO:0005125 8.92 TNFSF11 TNFRSF11B IL34 IL33

Sources for Chronic Apical Periodontitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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