MCID: CHR013
MIFTS: 29

Chronic Apical Periodontitis

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Chronic Apical Periodontitis

MalaCards integrated aliases for Chronic Apical Periodontitis:

Name: Chronic Apical Periodontitis 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:11269
ICD10 33 K04.5
ICD9CM 35 522.6
UMLS 73 C0392492

Summaries for Chronic Apical Periodontitis

MalaCards based summary : Chronic Apical Periodontitis is related to periodontitis and root resorption. An important gene associated with Chronic Apical Periodontitis is TNFRSF11B (TNF Receptor Superfamily Member 11b), and among its related pathways/superpathways are Osteoclast differentiation and Transcription_Role of VDR in regulation of genes involved in osteoporosis. The drugs Epinephrine and Racepinephrine have been mentioned in the context of this disorder. Affiliated tissues include bone.

Related Diseases for Chronic Apical Periodontitis

Diseases in the Acute Apical Periodontitis family:

Chronic Apical Periodontitis

Diseases related to Chronic Apical Periodontitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 36)
# Related Disease Score Top Affiliating Genes
1 periodontitis 30.7 TNFRSF11B TNFSF11
2 root resorption 30.1 TNFRSF11B TNFSF11
3 periapical periodontitis 29.0 SASS6 SLC52A2 TNFRSF11B TNFSF11
4 polyarticular onset juvenile idiopathic arthritis 10.4 TNFRSF11B TNFSF11
5 hemophilic arthropathy 10.4 TNFRSF11B TNFSF11
6 multicentric reticulohistiocytosis 10.4 TNFRSF11B TNFSF11
7 kummell's disease 10.3 TNFRSF11B TNFSF11
8 paget disease of bone 5, juvenile-onset 10.3 TNFRSF11B TNFSF11
9 periodontitis, chronic 10.3 TNFRSF11B TNFSF11
10 familial expansile osteolysis 10.3 TNFRSF11B TNFSF11
11 multicentric carpotarsal osteolysis syndrome 10.3 TNFRSF11B TNFSF11
12 tooth resorption 10.3 TNFRSF11B TNFSF11
13 glucocorticoid-induced osteoporosis 10.3 TNFRSF11B TNFSF11
14 ischemic bone disease 10.3 TNFRSF11B TNFSF11
15 endosteal hyperostosis, autosomal dominant 10.2 TNFRSF11B TNFSF11
16 bone resorption disease 10.2 TNFRSF11B TNFSF11
17 bone remodeling disease 10.2 TNFRSF11B TNFSF11
18 osteonecrosis 10.2 TNFRSF11B TNFSF11
19 giant cell tumor 10.2 TNFRSF11B TNFSF11
20 bone inflammation disease 10.2 TNFRSF11B TNFSF11
21 paget's disease of bone 10.1 TNFRSF11B TNFSF11
22 aortic valve disease 2 10.1 TNFRSF11B TNFSF11
23 synovitis 10.0 TNFRSF11B TNFSF11
24 arthropathy 10.0 TNFRSF11B TNFSF11
25 arteries, anomalies of 10.0
26 coronary artery anomaly 10.0
27 adenoiditis 9.8
28 adenoid cystic carcinoma 9.8
29 ossifying fibroma 9.8
30 depression 9.8
31 paresthesia 9.8
32 madras motor neuron disease 9.8 SLC52A2 SLC52A3
33 periodontal disease 9.8 TNFRSF11B TNFSF11
34 progressive bulbar palsy 9.7 SLC52A2 SLC52A3
35 brown-vialetto-van laere syndrome 9.7 SLC52A2 SLC52A3
36 psoriatic arthritis 9.6 TNFRSF11B TNFSF11

Graphical network of the top 20 diseases related to Chronic Apical Periodontitis:



Diseases related to Chronic Apical Periodontitis

Symptoms & Phenotypes for Chronic Apical Periodontitis

Drugs & Therapeutics for Chronic Apical Periodontitis

Drugs for Chronic Apical Periodontitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Epinephrine Approved, Vet_approved Not Applicable 51-43-4 5816
2
Racepinephrine Approved Not Applicable 329-65-7 838
3 Anti-Infective Agents Not Applicable
4 Disinfectants Not Applicable
5 Eusol Not Applicable
6 Pharmaceutical Solutions Not Applicable
7 Sodium hypochlorite Not Applicable
8 Epinephryl borate Not Applicable
9
s 1 (combination) Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Longitudinal Endodontic Study of Apical Preparation Size Completed NCT00223379 Not Applicable
2 Cytokine Regulation of Periradicular Pain in Humans Completed NCT00223470
3 Effect of Sodium Hypochlorite Concentration on Success of Non-surgical Root Canal Treatment Completed NCT03288467 Not Applicable
4 Postoperative Pain After the Removal of Root Canal Filling Material Completed NCT02905773 Early Phase 1
5 Effect of Different Instrumentation Technique on Endodontic Outcome Completed NCT03278054 Not Applicable
6 Measurement of Bite Force in Humans Completed NCT00223327

Search NIH Clinical Center for Chronic Apical Periodontitis

Genetic Tests for Chronic Apical Periodontitis

Anatomical Context for Chronic Apical Periodontitis

MalaCards organs/tissues related to Chronic Apical Periodontitis:

41
Bone

Publications for Chronic Apical Periodontitis

Articles related to Chronic Apical Periodontitis:

(show all 31)
# Title Authors Year
1
Expression of Osteoprotegrin and Osteoclast Level in Chronic Apical Periodontitis Induced with East Java Propolis Extract. ( 29692834 )
2018
2
Dickkopf-1 may regulate bone coupling by attenuating wnt/I^-catenin signaling in chronic apical periodontitis. ( 29216526 )
2018
3
Adenoid Cystic Carcinoma of Maxillary Sinus Misdiagnosed as Chronic Apical Periodontitis. ( 28236426 )
2017
4
Increased Root Canal Endotoxin Levels are Associated with Chronic Apical Periodontitis, Increased Oxidative and Nitrosative Stress, Major Depression, Severity of Depression, and a Lowered Quality of Life. ( 28455694 )
2017
5
Clinical, imagistic and histopathological study of chronic apical periodontitis. ( 27833964 )
2016
6
Cellular Profile and Expression of Immunologic Markers in Chronic Apical Periodontitis fromA HIV-infected Patients Undergoing HighlyA Active Antiretroviral Therapy. ( 27118467 )
2016
7
Lipids and lipoproteins and inflammatory markers in patients with chronic apical periodontitis. ( 26666260 )
2015
8
Association between chronic apical periodontitis and low-birth-weight preterm births. ( 25576210 )
2015
9
The use of cone beam computed tomography in the diagnosis and management of internal root resorption associated with chronic apical periodontitis: a case report. ( 25826508 )
2015
10
Clinical study of single-visit root canal treatment with a nickel-titanium (Ni-Ti) rotary instrument combined with different ultrasonic irrigation solutions for elderly patients with chronic apical periodontitis. ( 26406018 )
2015
11
Association between chronic apical periodontitis and coronary artery disease. ( 24461397 )
2014
12
Chronic apical periodontitis is more common in subjects with coronary artery disease. ( 25234220 )
2014
13
Monitoring the effectiveness of root canal procedures on endotoxin levels found in teeth with chronic apical periodontitis. ( 25075670 )
2014
14
Endodontic retreatment of dens invaginatus presenting with gutta-percha overfilling at the attached gingiva and chronic apical periodontitis: unusual clinical report. ( 24172007 )
2013
15
Masticatory tensile developed in upper anterior teeth with chronic apical periodontitis. A finite-element analysis study. ( 24068408 )
2013
16
The association of chronic apical periodontitis and endodontic therapy with atherosclerosis. ( 24338091 )
2013
17
Receptor activator of nuclear factor kappa B ligand and osteoprotegerin expression in chronic apical periodontitis: possible association with inflammatory cells. ( 21933620 )
2011
18
Distribution of Porphyromonas gingivalis fimA genotypes in chronic apical periodontitis associated with symptoms. ( 20951289 )
2010
19
Digital subtraction radiography evaluation of the bone repair process of chronic apical periodontitis after root canal treatment. ( 20491984 )
2010
20
Ossifying fibroma misdiagnosed as chronic apical periodontitis. ( 20171381 )
2010
21
Root canal microbiota of teeth with chronic apical periodontitis. ( 18768651 )
2008
22
Profiling of root canal bacterial communities associated with chronic apical periodontitis from Brazilian and Norwegian subjects. ( 19026873 )
2008
23
[Expression of receptor activator of nuclear factor kappaB ligand and osteoprotegerin in chronic apical periodontitis]. ( 18278135 )
2008
24
The influence of chronic apical periodontitis on oral and general health. ( 18078141 )
2007
25
C-reactive protein and serum amyloid A in a canine model of chronic apical periodontitis. ( 16186751 )
2005
26
Digital radiograph registration and subtraction: a useful tool for the evaluation of the progress of chronic apical periodontitis. ( 15220649 )
2004
27
Isolation of yeasts and enteric bacteria in root-filled teeth with chronic apical periodontitis. ( 11556508 )
2001
28
Time-course and risk analyses of the development and healing of chronic apical periodontitis in man. ( 9206419 )
1996
29
Anaerobic microorganisms in root canals of human teeth with chronic apical periodontitis detected by indirect immunofluorescence. ( 9028199 )
1996
30
The role of reactive oxygen intermediates in the pathogenesis of chronic apical periodontitis. ( 8247615 )
1993
31
Paresthesia of the mental nerve after an acute exacerbation of chronic apical periodontitis. ( 6945343 )
1981

Variations for Chronic Apical Periodontitis

Expression for Chronic Apical Periodontitis

Search GEO for disease gene expression data for Chronic Apical Periodontitis.

Pathways for Chronic Apical Periodontitis

Pathways related to Chronic Apical Periodontitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.43 TNFRSF11B TNFSF11
2 10.91 TNFRSF11B TNFSF11
3 10.63 TNFRSF11B TNFSF11
4 10.16 TNFRSF11B TNFSF11
5 9.77 TNFRSF11B TNFSF11

GO Terms for Chronic Apical Periodontitis

Cellular components related to Chronic Apical Periodontitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 8.92 SLC52A2 SLC52A3 TNFRSF11B TNFSF11

Biological processes related to Chronic Apical Periodontitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.33 IL34 TNFRSF11B TNFSF11
2 tumor necrosis factor-mediated signaling pathway GO:0033209 9.26 TNFRSF11B TNFSF11
3 riboflavin metabolic process GO:0006771 8.96 SLC52A2 SLC52A3
4 riboflavin transport GO:0032218 8.62 SLC52A2 SLC52A3

Molecular functions related to Chronic Apical Periodontitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.13 IL34 TNFRSF11B TNFSF11
2 riboflavin transmembrane transporter activity GO:0032217 8.62 SLC52A2 SLC52A3

Sources for Chronic Apical Periodontitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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