MCID: CHR711
MIFTS: 41

Chronic Asthma

Categories: Genetic diseases, Immune diseases, Mental diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Chronic Asthma

MalaCards integrated aliases for Chronic Asthma:

Name: Chronic Asthma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0080809

Summaries for Chronic Asthma

Disease Ontology : 12 An asthma that is characterized by the development of persistent airway inflammation and recurrent attacks of breathlessness and wheezing, which vary in severity and frequency.

MalaCards based summary : Chronic Asthma is related to childhood-onset asthma and cough variant asthma. An important gene associated with Chronic Asthma is IGHE (Immunoglobulin Heavy Constant Epsilon), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Hormones and Anti-Inflammatory Agents have been mentioned in the context of this disorder. Affiliated tissues include smooth muscle, t cells and pituitary, and related phenotypes are digestive/alimentary and reproductive system

Related Diseases for Chronic Asthma

Diseases in the Asthma family:

Chronic Asthma Acute Asthma
Adult-Onset Severe Asthma

Diseases related to Chronic Asthma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 288)
# Related Disease Score Top Affiliating Genes
1 childhood-onset asthma 31.5 RNASE3 IL13 IGHE
2 cough variant asthma 30.9 RNASE3 IL5 IL4 IGHE
3 intrinsic asthma 30.5 RNASE3 IL5 IL4 IL13 IGHE
4 cytokine deficiency 30.2 IL5 IL13
5 status asthmaticus 30.0 RNASE3 IL5 CCL11
6 exercise-induced bronchoconstriction 29.9 RNASE3 IL13 ALOX5
7 acute asthma 29.9 RNASE3 IL5 IL4 ALOX5
8 bronchitis 29.3 RNASE3 IL5 IL4 IL13 CCL11
9 allergic asthma 29.2 RNASE3 IL5 IL4 IL13 IGHE CCL11
10 ige responsiveness, atopic 29.1 RNASE3 IL5 IL4 IL13 IGHE
11 gastroesophageal reflux 29.1 IL5 IL4 EGF CCL11
12 pulmonary disease, chronic obstructive 29.1 RNASE3 IL5 IL4 IL13 CCL11
13 lung disease 29.0 RNASE3 IL5 IL4 IL13 BMP6
14 food allergy 28.9 RNASE3 IL5 IL4 IL13 IGHE
15 asthma 28.7 RNASE3 IL5 IL4 IL33 IL2 IL13
16 hypereosinophilic syndrome 28.6 RNASE3 IL5 IL4 IL2 IL13 IGHE
17 allergic rhinitis 28.6 RNASE3 IL5 IL4 IL13 IGHE CCL11
18 bronchiolitis 28.6 RNASE3 IL5 IL4 IL13 CCL11
19 osteoporosis 28.5 IL4 IL33 IL2 EGF BMP6
20 rhinitis 28.5 RNASE3 IL5 IL4 IL33 IL13 IGHE
21 esophagitis 28.4 RNASE3 IL5 IL4 IL33 IL13 CCL11
22 common cold 28.3 RNASE3 IL5 IL4 IL33 IL13 CCL11
23 psoriasis 28.2 IL5 IL4 IL2 IL13 EGF ALOX5
24 allergic disease 28.2 RNASE3 IL5 IL4 IL33 IL2 IL13
25 proteasome-associated autoinflammatory syndrome 1 28.1 RNASE3 IL5 IL4 IL13 IGHE CCL11
26 esophagitis, eosinophilic, 1 28.1 RNASE3 IL5 IL4 IL33 IL13 CCL11
27 pulmonary fibrosis, idiopathic 27.7 IL5 IL4 IL33 IL13 EGF BMP6
28 intermittent asthma 11.0
29 persistent mild asthma 10.9
30 persistent moderate asthma 10.9
31 adult-onset severe asthma 10.9
32 t2-high asthma 10.9
33 t2-low asthma 10.9
34 persistent severe asthma 10.9
35 candidiasis 10.4
36 oral candidiasis 10.3
37 anisakiasis 10.3 RNASE3 IGHE
38 farmer's lung 10.3 IL2 IGHE
39 clonorchiasis 10.3 IL2 IGHE
40 asthma-related traits 2 10.3
41 eustachian tube disease 10.2 RNASE3 CCL11
42 viral laryngitis 10.2 RNASE3 GPT
43 cellular leiomyoma 10.2 CCL11 BMP6
44 tuberculoid leprosy 10.2 IL2 BMP6
45 muscle hypertrophy 10.2
46 tremor 10.2
47 loeffler endocarditis 10.2 RNASE3 IL5
48 eosinophilic fasciitis 10.2 IL5 BMP6
49 chlamydia 10.2
50 cholecystolithiasis 10.2 GPT BMP6

Graphical network of the top 20 diseases related to Chronic Asthma:



Diseases related to Chronic Asthma

Symptoms & Phenotypes for Chronic Asthma

MGI Mouse Phenotypes related to Chronic Asthma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.63 EGF IL13 IL2 IL33 IL4 IL5
2 reproductive system MP:0005389 9.5 BMP6 EGF IL13 IL2 IL33 IL4
3 respiratory system MP:0005388 9.1 CCL11 IL13 IL2 IL33 IL4 IL5

Drugs & Therapeutics for Chronic Asthma

Drugs for Chronic Asthma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 54)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Hormones Phase 4
2 Anti-Inflammatory Agents Phase 4
3 Hormone Antagonists Phase 4
4 Leukotriene Antagonists Phase 4
5 Platelet Aggregation Inhibitors Phase 4
6 Prasugrel hydrochloride Phase 4 389574-19-0
7 Antirheumatic Agents Phase 4
8 Analgesics, Non-Narcotic Phase 4
9 Anti-Inflammatory Agents, Non-Steroidal Phase 4
10 Analgesics Phase 4
11
Insulin glargine Approved Phase 3 160337-95-1
12
Zinc Approved, Investigational Phase 3 7440-66-6 32051
13
Atorvastatin Approved Phase 2, Phase 3 134523-00-5 60823
14
Nedocromil Approved, Investigational Phase 3 69049-73-6 50294
15
Levoleucovorin Approved, Investigational Phase 3 68538-85-2 149436
16
Omalizumab Approved, Investigational Phase 3 242138-07-4
17
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
18
Folic acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
19
Beclomethasone Phase 3 4419-39-0 20469
20 Insulin, Globin Zinc Phase 3
21 Hypoglycemic Agents Phase 3
22 Insulin, Short-Acting Phase 3
23 Insulin, Isophane Phase 3
24 Isophane Insulin, Human Phase 3
25 insulin Phase 3
26 Protamines Phase 3
27 Isophane insulin, beef Phase 3
28 Methacholine Chloride Phase 2, Phase 3
29 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 2, Phase 3
30 Hypolipidemic Agents Phase 2, Phase 3
31 Anticholesteremic Agents Phase 2, Phase 3
32 Lipid Regulating Agents Phase 2, Phase 3
33 Cromolyn Sodium Phase 3
34 Vitamin B Complex Phase 3
35 Immunosuppressive Agents Phase 3
36 Folic Acid Antagonists Phase 3
37 Vitamin B9 Phase 3
38 Immunologic Factors Phase 3
39 Antimetabolites Phase 3
40 Folate Phase 3
41
mometasone furoate Approved, Investigational, Vet_approved Phase 2 83919-23-7
42 Albuterol Phase 2
43 Adrenergic beta-Agonists Phase 2
44 Adrenergic Agonists Phase 2
45 Neurotransmitter Agents Phase 2
46 Tocolytic Agents Phase 2
47 Adrenergic Agents Phase 2
48 Pharmaceutical Solutions Phase 2
49 Phosphodiesterase 4 Inhibitors Phase 2
50
Procaterol Approved, Investigational Phase 1 72332-33-3 688561

Interventional clinical trials:

(show all 27)
# Name Status NCT ID Phase Drugs
1 TEAM (Trial on Efficacy and Quality of Life Among Asthmatic Patient With Montelukast) Completed NCT03096327 Phase 4 Montelukast;Placebo
2 The Effect of Prasugrel on Bronchial Hyperreactivity and on Markers of Inflammation in Patients With Chronic Asthma: a Pilot Randomised Controlled Trial (PRINA Study) Completed NCT01305369 Phase 4 Prasugrel
3 A Single-Center, Open-Label, Single-Dose Evaluation of the Duration and Extent of Bronchodilation Following Administration of Zileuton CR 1200 mg in Subjects With Stable, Chronic Asthma Completed NCT01805687 Phase 4 Zileuton extended release
4 A Multicenter, Randomized, Placebo-Controlled, Double-Blind, 2-Period, Parallel-Group Study to Assess the Clinical Effect of MK0476 With Concomitant Administration of and Removal of Inhaled Beclomethasone in Asthmatic Patients Completed NCT00911547 Phase 3 montelukast sodium;beclomethasone;Placebo inhaler;placebo tablet
5 A Multicenter, Randomized, Double-blind, Placebo-Controlled Parallel Group 8-week Study to Evaluate the Efficacy and Safety of Chewable Montelukast When Initiated at the Start of the School Year in Pediatric Patients With Chronic Asthma Completed NCT00461032 Phase 3 montelukast;Comparator: Placebo
6 A Multicenter, Double-Blind, Randomized Study Investigating the Clinical Effect of Montelukast on Allergic Rhinitis in Patients With Seasonal Allergic Rhinitis and Chronic Asthma Completed NCT00092885 Phase 3 MK0476, montelukast sodium;Comparator: placebo
7 A Multicenter, Randomized, Double-Blind, Parallel-Group 6-Month Study to Evaluate the Efficacy and Safety of Oral Montelukast Sodium, Fluticasone Propionate and Placebo in Patients With Chronic Asthma Who Smoke Cigarettes Completed NCT00284856 Phase 3 montelukast sodium;Comparator: Placebo;Comparator: fluticasone;Comparator: Placebo
8 A 24-Week, Double-Blind, Parallel Group, Placebo and Active Controlled Study to Investigate the Efficacy and Safety of Daily Oral Roflumilast Taken With Low Dose Inhaled Corticosteroids in Patients With Chronic Asthma Completed NCT00163527 Phase 3 Roflumilast
9 Efficacy and Safety of Inhaled Human Insulin (Exubera) Compared With Subcutaneous Human Insulin in the Therapy of Adult Subjects With Type 1 or Type 2 Diabetes Mellitus and Chronic Asthma: A One-Year, Multicenter, Randomized, Outpatient, Open-Label, Parallel-Group Comparative Trial Completed NCT00139659 Phase 3 Inhaled Insulin;Subcutaneous Insulin
10 Randomised Controlled Trial to Evaluate the Effect of Statins on Asthma Control of Patients With Chronic Asthma Completed NCT00126048 Phase 2, Phase 3 Atorvastatin;Placebo
11 A Multicenter, Double-Blind, Placebo-Controlled, Randomized, Parallel-Group Study to Evaluate the Clinical Effect of Oral MK0476 Vs Placebo During the Allergy Season in Patients With Seasonal Aeroallergen Sensitivity and Chronic Asthma Which is Also Active During Allergy Season Completed NCT00092144 Phase 3 MK0476, montelukast sodium / Duration of Treatment: 4 weeks;Comparator: placebo / Duration of Treatment: 4 weeks
12 A Multicenter, Open-Label, Controlled, Extended Safety Study of Montelukast in Infants and Young Children With Chronic Asthma Completed NCT00943397 Phase 3 montelukast sodium;Comparator: Usual Care
13 A Multicenter, Double-Blind, Randomized, Parallel-Group Chronic Asthma Study Comparing Montelukast With Placebo in 2- to 5-Year-Old Patients Completed NCT00968201 Phase 3 montelukast sodium;Comparator: Placebo
14 Low-dose Methotrexate for Change in Global Initiative for Asthma Step 5 Medications in Chronic Severe Asthma: a Randomized Controlled Trial Not yet recruiting NCT02124226 Phase 3 Methotrexate;Placebo
15 A Phase III Double-Blind, Randomized, Placebo-Controlled Clinical Trial to Prospectively Evaluate Efficacy of Montelukast in Patients Aged 6 Months to 5 Years With Chronic Asthma Withdrawn NCT00540839 Phase 3 Montelukast sodium;Placebo to montelukast;Fluticasone propionate;Placebo to fluticasone
16 Randomized, Placebo-controlled Clinical Trial to Study the Efficacy and Safety of Inhaled Corticosteroid Plus Montelukast Compared With Inhaled Corticosteroid Therapy Alone in Patients With Chronic Asthma Completed NCT00666679 Phase 2 Comparator: mometasone;Comparator: montelukast;Comparator: placebo (unspecified)
17 A Multicenter, Randomized, Double-Blind, Crossover Study Comparing the Effect of MK0359 and Placebo in Adult Patients With Chronic Asthma Completed NCT00482898 Phase 2 MK0359
18 A Multicenter, Randomized, Double Blind, Crossover Study Comparing the Effect of MK0524 With Placebo and Concomitant Administration of MK0524 Plus Montelukast in Adult Patients With Chronic Asthma Completed NCT00783601 Phase 2 Comparator: MK0524 + placebo;Comparator: MK0524 + montelukast;Comparator: placebo + montelukast;Comparator: Placebo
19 A Phase II, Randomised, Double Blind, Placebo Controlled, Seven Way Crossover Study to Assess the Effect of Single Doses of RPL554 Compared to Salbutamol and Placebo Administered by Nebuliser on Lung Function of Patients With Chronic Asthma Completed NCT02427165 Phase 2 RPL554;Salbutamol;Placebo
20 A Double-Blind, Randomized, Placebo-Controlled, Multicenter, Parallel-Group, Dose-Ranging Study of MK0633 in Adult Patients With Chronic Asthma Terminated NCT00404313 Phase 2 MK0633;Comparator: placebo
21 A Phase Ib Randomized, Placebo-Controlled Clinical Trial to Study the Safety and Bronchodilatory Effect of MK0476 in Patients With Chronic Asthma Completed NCT00739297 Phase 1 Comparator: montelukast;Comparator: placebo
22 A Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose, Phase I Study to Evaluate the Safety, Tolerability and Pharmacokinetics of Inhaled Laninamivir Octanoate in Adults With Chronic Asthma Completed NCT02022761 Phase 1 Laninamivir octanoate
23 Impact of a Pharmaceutical Care Intervention to Improve Adherence of Inhaled Medication in Asthma and COPD Patients Completed NCT02386722
24 Montelukast in Chronic Asthma: Non-interventional Study With Montelukast 10 mg Completed NCT00802789
25 Effects of Submaximal Regular Physical Exercise on Quality of Life, Symptomatic Control, and Bronchial and Systemic Inflammatory Markers in Patients With Persistent Asthma Recruiting NCT04395937
26 Investigation the Safety and Efficacy of The Antileukotriene Agents, Montelukast, as Adjuvant Therapy in Obese Patients With Type 2 Diabetes Mellitus: A Randomized, Controlled Trial Active, not recruiting NCT04075110 Early Phase 1 Montelukast 10mg
27 Initiation of Chronic Asthma Care Regimens in the Pediatric Emergency Department Withdrawn NCT00388739 Intervention: Budesonide;Usual care: albuterol + systemic steroids

Search NIH Clinical Center for Chronic Asthma

Genetic Tests for Chronic Asthma

Anatomical Context for Chronic Asthma

MalaCards organs/tissues related to Chronic Asthma:

40
Smooth Muscle, T Cells, Pituitary, Lung, Bronchial Epithelium, Neutrophil, Endothelial

Publications for Chronic Asthma

Articles related to Chronic Asthma:

(show top 50) (show all 2251)
# Title Authors PMID Year
1
Mas receptor activation attenuates allergic airway inflammation via inhibiting JNK/CCL2-induced macrophage recruitment. 61
33588264 2021
2
p62-dependent autophagy in airway smooth muscle cells regulates metabolic reprogramming and promotes airway remodeling. 61
33310038 2021
3
Pilot study investigating diagnostic utility of serum MMP-1 and TGF-β1 in asthma in 'real world' clinical practice in India. 61
33597224 2021
4
Quantitative analysis of proteome dynamics in a mouse model of asthma. 61
33550702 2021
5
Impact of Technology Based Interventions on Patient Reported Outcomes in Asthma: A Systematic Review. 61
33548519 2021
6
Comparative analysis of the role of mastcells in murine asthma models using Kit-sufficient mast cell-deficient animals. 61
33559884 2021
7
MicroRNA-21 inhibition attenuates airway inflammation and remodelling by modulating the transforming growth factor β-Smad7 pathway. 61
33601867 2021
8
Acupuncture for chronic persistent asthma based on the theory of Meridian-viscera Association: study protocol for a multi-center randomized controlled trial in China. 61
33407788 2021
9
Hypoxic hUCMSC-derived extracellular vesicles attenuate allergic airway inflammation and airway remodeling in chronic asthma mice. 61
33407872 2021
10
GM-CSF instigates a dendritic cell-T-cell inflammatory circuit that drives chronic asthma development. 61
33440200 2021
11
Preventing asthma in high risk kids (PARK) with omalizumab: Design, rationale, methods, lessons learned and adaptation. 61
33242697 2021
12
An enhanced care package to improve asthma management in Malawian children: a randomised controlled trial. 61
33479040 2021
13
Characterization of Negative Allosteric Modulators of the Calcium-Sensing Receptor for Repurposing as a Treatment of Asthma. 61
33115824 2021
14
Nephroprotection through Modifying the Apoptotic TNF-α/ERK1/2/Bax Signaling Pathway and Oxidative Stress by Long-term Sodium Hydrosulfide Administration in Ovalbumin-induced Chronic Asthma. 61
33342312 2020
15
Alteration of Lung and Gut Microbiota in IL-13-Transgenic Mice Simulating Chronic Asthma. 61
33046682 2020
16
Role of biomarkers and effect of FIP-fve in acute and chronic animal asthma models. 61
32778497 2020
17
Protective effects of ascorbic acid and calcitriol combination on airway remodelling in ovalbumin-induced chronic asthma. 61
31942829 2020
18
Impact of pneumococcal vaccine response on asthma exacerbation frequency in young children. 61
32677745 2020
19
Therapeutic efficacy of pulmonary live tuberculosis vaccines against established asthma by subverting local immune environment. 61
33478923 2020
20
Management of Asthma Exacerbations in the Emergency Department. 61
33387672 2020
21
Fungal sensitization and positive fungal culture from sputum in children with asthma are associated with reduced lung function and acute asthma attacks respectively. 61
33274520 2020
22
Beyond tobacco - the secondary impact of substance misuse in chronic obstructive lung disease. 61
33158365 2020
23
Aryl hydrocarbon receptor deficiency enhanced airway inflammation and remodeling in a murine chronic asthma model. 61
32959404 2020
24
Asthma Promotes Choroidal Neovascularization via the Transforming Growth Factor beta1/Smad Signaling Pathway in a Mouse Model. 61
32781454 2020
25
Statins for asthma. 61
32668027 2020
26
Residential instability, neighborhood deprivation, and pediatric asthma outcomes. 61
32275809 2020
27
Nanoparticle-based thymulin gene therapy therapeutically reverses key pathology of experimental allergic asthma. 61
32577505 2020
28
Cardiac autonomic modulation assessed by heart rate variability in children with asthma. 61
32119199 2020
29
Treat to target approach for asthma. 61
30907188 2020
30
Nebulized Inhaled Corticosteroids in Asthma Treatment in Children 5 Years or Younger: A Systematic Review and Global Expert Analysis. 61
32006721 2020
31
Inducible epithelial resistance against acute Sendai virus infection prevents chronic asthma-like lung disease in mice. 61
31968123 2020
32
Treatment with inhaled formulation of angiotensin-(1-7) reverses inflammation and pulmonary remodeling in a model of chronic asthma. 61
32517880 2020
33
Qi-Wei-Du-Qi-Wan and its major constituents exert an anti-asthmatic effect by inhibiting mast cell degranulation. 61
31751647 2020
34
Parental perception of a picture-based chronic asthma care management tool in an urban pediatric emergency department. 61
32249659 2020
35
Evaluation of C-C Chemokine Ligand 5 (CCL5) Chemokine, Interleukin 5 (IL-5) Cytokine, and Eosinophil Counts as Potential Biomarkers in Saudi Patients with Chronic Asthma During Sandstorms. 61
32467785 2020
36
[Recombinant pyrin domain protein attenuates airway inflammation and airway remodeling through TGF-β1/SMAD and Jagged1/Notch1 signaling pathways in chronic bronchial asthma mice]. 61
32389169 2020
37
Exploratory study of language paediatricians use to promote adherence to long-term controller medication in children with asthma. 61
32111407 2020
38
Considerations for the Child with Nonatopic Asthma. 61
33406019 2020
39
TRPV4 is dispensable for the development of airway allergic asthma. 61
31417159 2020
40
Colony-stimulating factor 1 and its receptor are new potential therapeutic targets for allergic asthma. 61
31385613 2020
41
Lung functional development and asthma trajectories. 61
31989229 2020
42
Inhibition of soluble epoxide hydrolase attenuates airway remodeling in a chronic asthma model. 61
31866410 2020
43
Outpatient Management of Chronic Asthma in 2020. 61
32044930 2020
44
Icariin alleviates transforming growth factor-β1-induced epithelial-mesenchymal transition by targeting Smad and MAPK signaling pathways. 61
32194888 2020
45
Metabolic Adaptation of Airway Smooth Muscle Cells to an SPHK2 Substrate Precedes Cytostasis. 61
31247144 2020
46
Tracheal Adenoid Cystic Carcinoma Presented with Chronic Asthma Diagnosed by Bronchial Washing Cytology. 61
32015749 2020
47
Erratum to "Tetrandrine Ameliorates Airway Remodeling of Chronic Asthma by Interfering TGF-β1/Nrf-2/HO-1 Signaling Pathway-Mediated Oxidative Stress". 61
32318125 2020
48
Expression of SMARCD1 interacts with age in association with asthma control on inhaled corticosteroid therapy. 61
31992292 2020
49
Airway Remodeling in Asthma. 61
32509793 2020
50
Effects of Boldine on Antioxidants and Allied Inflammatory Markers in Mouse Models of Asthma. 61
32865914 2020

Variations for Chronic Asthma

Expression for Chronic Asthma

Search GEO for disease gene expression data for Chronic Asthma.

Pathways for Chronic Asthma

Pathways related to Chronic Asthma according to GeneCards Suite gene sharing:

(show all 31)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.85 RNASE3 IL5 IL4 IL33 IL2 IL13
2
Show member pathways
13.66 IL5 IL4 IL2 IL13 EGF CCL11
3
Show member pathways
13.54 IL5 IL4 IL33 IL2 IL13 CCL11
4
Show member pathways
13.4 IL5 IL4 IL2 IL13 EGF CCL11
5
Show member pathways
13.28 IL5 IL4 IL2 IL13 EGF CCL11
6
Show member pathways
13.16 IL5 IL4 IL2 IL13 EGF CCL11
7
Show member pathways
13.02 IL5 IL4 IL33 IL2 IL13 IGHE
8 12.73 IL5 IL4 IL2 IL13 EGF
9
Show member pathways
12.73 RNASE3 IL5 IL4 IL2 IL13 CCL11
10
Show member pathways
12.5 IL5 IL4 IL13 IGHE ALOX5
11
Show member pathways
12.48 IL5 IL4 IL2 EGF
12
Show member pathways
12.47 IL5 IL4 IL2 IL13
13
Show member pathways
12.33 IL5 IL4 IL2 IL13 EGF
14
Show member pathways
12.24 IL5 IL4 IL13 CCL11
15
Show member pathways
12.18 IL5 IL4 IL2 IL13 BMP6
16
Show member pathways
11.91 IL5 IL2 IL13
17 11.89 IL4 IL13 IGHE CCL11 ALOX5
18 11.88 IL5 IL4 IL2
19 11.74 IL5 IL4 IL2 IL13
20
Show member pathways
11.68 IL5 IL4 IL2
21 11.58 IL5 IL4 IGHE CCL11
22 11.46 IL5 IL4 IL33 IL2 IL13
23 11.28 IL5 IL4 IL2
24 11.21 IL5 IL4 IL33 IL13
25 11.15 IL5 IL4 IL13 EGF CCL11
26 11.13 IL5 IL4 IL2 IL13
27 11.1 IL2 IL13
28 11.04 IL5 IL4 IL2 IL13
29 10.9 IL5 IL4 IL2 IL13 EGF CCL11
30 10.76 IL5 IL4 IL33 IL2 IL13 CCL11
31 10.75 IL5 IL4 IL13

GO Terms for Chronic Asthma

Cellular components related to Chronic Asthma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 RNASE3 IL5 IL4 IL33 IL2 IL13
2 extracellular space GO:0005615 9.36 RNASE3 IL5 IL4 IL33 IL2 IL13

Biological processes related to Chronic Asthma according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.85 IL5 IL4 IL2 EGF BMP6
2 positive regulation of gene expression GO:0010628 9.83 IL4 IL33 IL13 EGF BMP6
3 inflammatory response GO:0006954 9.77 IL5 IL13 CCL11 BMP6 ALOX5
4 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.72 IL5 EGF BMP6
5 immune response GO:0006955 9.7 IL5 IL4 IL2 IL13 IGHE CCL11
6 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.67 IL4 IL2 IL13
7 positive regulation of endothelial cell proliferation GO:0001938 9.65 EGF CCL11 BMP6
8 negative regulation of inflammatory response GO:0050728 9.62 IL4 IL2 IL13 ALOX5
9 microglial cell activation GO:0001774 9.61 IL4 IL13
10 innate immune response in mucosa GO:0002227 9.6 RNASE3 IL4
11 positive regulation of T cell differentiation GO:0045582 9.59 IL4 IL2
12 positive regulation of macrophage activation GO:0043032 9.58 IL33 IL13
13 macrophage activation GO:0042116 9.58 IL4 IL13
14 positive regulation of MHC class II biosynthetic process GO:0045348 9.57 IL4 IL33
15 positive regulation of interleukin-13 production GO:0032736 9.56 IL4 IL33
16 positive regulation of B cell proliferation GO:0030890 9.56 IL5 IL4 IL2 IL13
17 negative regulation of T-helper 17 cell differentiation GO:2000320 9.54 IL4 IL2
18 positive regulation of isotype switching to IgG isotypes GO:0048304 9.52 IL4 IL2
19 positive regulation of mast cell degranulation GO:0043306 9.51 IL4 IL13
20 negative regulation of complement-dependent cytotoxicity GO:1903660 9.4 IL4 IL13
21 positive regulation of immunoglobulin production GO:0002639 9.26 IL5 IL33 IL2 IL13
22 cytokine-mediated signaling pathway GO:0019221 9.17 IL5 IL4 IL2 IL13 IGHE CCL11

Molecular functions related to Chronic Asthma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.35 IL5 IL4 IL2 EGF BMP6
2 cytokine activity GO:0005125 9.17 IL5 IL4 IL33 IL2 IL13 CCL11
3 cytokine receptor binding GO:0005126 9.16 IL4 IL13

Sources for Chronic Asthma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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