Chronic Asthma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: CHR711 MIFTS: 41	Chronic Asthma Categories: Genetic diseases, Immune diseases, Mental diseases, Rare diseases, Respiratory diseases
Genes Tissues Related diseases Publications Pathways Drugs Expand all tables

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Aliases & Classifications for Chronic Asthma

MalaCards integrated aliases for Chronic Asthma:

Name: Chronic Asthma ¹²

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases
Anatomical: Respiratory diseases Immune diseases Mental diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0080809

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Summaries for Chronic Asthma

Disease Ontology : ¹² An asthma that is characterized by the development of persistent airway inflammation and recurrent attacks of breathlessness and wheezing, which vary in severity and frequency.

MalaCards based summary : Chronic Asthma is related to childhood-onset asthma and cough variant asthma. An important gene associated with Chronic Asthma is IGHE (Immunoglobulin Heavy Constant Epsilon), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Hormones and Anti-Inflammatory Agents have been mentioned in the context of this disorder. Affiliated tissues include smooth muscle, t cells and pituitary, and related phenotypes are digestive/alimentary and reproductive system

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Related Diseases for Chronic Asthma

Diseases in the Asthma family:

Chronic Asthma	Acute Asthma
Adult-Onset Severe Asthma

Diseases related to Chronic Asthma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 288)

#	Related Disease	Score	Top Affiliating Genes
1	childhood-onset asthma	31.5	RNASE3 IL13 IGHE
2	cough variant asthma	30.9	RNASE3 IL5 IL4 IGHE
3	intrinsic asthma	30.5	RNASE3 IL5 IL4 IL13 IGHE
4	cytokine deficiency	30.2	IL5 IL13
5	status asthmaticus	30.0	RNASE3 IL5 CCL11
6	exercise-induced bronchoconstriction	29.9	RNASE3 IL13 ALOX5
7	acute asthma	29.9	RNASE3 IL5 IL4 ALOX5
8	bronchitis	29.3	RNASE3 IL5 IL4 IL13 CCL11
9	allergic asthma	29.2	RNASE3 IL5 IL4 IL13 IGHE CCL11
10	ige responsiveness, atopic	29.1	RNASE3 IL5 IL4 IL13 IGHE
11	gastroesophageal reflux	29.1	IL5 IL4 EGF CCL11
12	pulmonary disease, chronic obstructive	29.1	RNASE3 IL5 IL4 IL13 CCL11
13	lung disease	29.0	RNASE3 IL5 IL4 IL13 BMP6
14	food allergy	28.9	RNASE3 IL5 IL4 IL13 IGHE
15	asthma	28.7	RNASE3 IL5 IL4 IL33 IL2 IL13
16	hypereosinophilic syndrome	28.6	RNASE3 IL5 IL4 IL2 IL13 IGHE
17	allergic rhinitis	28.6	RNASE3 IL5 IL4 IL13 IGHE CCL11
18	bronchiolitis	28.6	RNASE3 IL5 IL4 IL13 CCL11
19	osteoporosis	28.5	IL4 IL33 IL2 EGF BMP6
20	rhinitis	28.5	RNASE3 IL5 IL4 IL33 IL13 IGHE
21	esophagitis	28.4	RNASE3 IL5 IL4 IL33 IL13 CCL11
22	common cold	28.3	RNASE3 IL5 IL4 IL33 IL13 CCL11
23	psoriasis	28.2	IL5 IL4 IL2 IL13 EGF ALOX5
24	allergic disease	28.2	RNASE3 IL5 IL4 IL33 IL2 IL13
25	proteasome-associated autoinflammatory syndrome 1	28.1	RNASE3 IL5 IL4 IL13 IGHE CCL11
26	esophagitis, eosinophilic, 1	28.1	RNASE3 IL5 IL4 IL33 IL13 CCL11
27	pulmonary fibrosis, idiopathic	27.7	IL5 IL4 IL33 IL13 EGF BMP6
28	intermittent asthma	11.0
29	persistent mild asthma	10.9
30	persistent moderate asthma	10.9
31	adult-onset severe asthma	10.9
32	t2-high asthma	10.9
33	t2-low asthma	10.9
34	persistent severe asthma	10.9
35	candidiasis	10.4
36	oral candidiasis	10.3
37	anisakiasis	10.3	RNASE3 IGHE
38	farmer's lung	10.3	IL2 IGHE
39	clonorchiasis	10.3	IL2 IGHE
40	asthma-related traits 2	10.3
41	eustachian tube disease	10.2	RNASE3 CCL11
42	viral laryngitis	10.2	RNASE3 GPT
43	cellular leiomyoma	10.2	CCL11 BMP6
44	tuberculoid leprosy	10.2	IL2 BMP6
45	muscle hypertrophy	10.2
46	tremor	10.2
47	loeffler endocarditis	10.2	RNASE3 IL5
48	eosinophilic fasciitis	10.2	IL5 BMP6
49	chlamydia	10.2
50	cholecystolithiasis	10.2	GPT BMP6

Graphical network of the top 20 diseases related to Chronic Asthma:

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Symptoms & Phenotypes for Chronic Asthma

MGI Mouse Phenotypes related to Chronic Asthma:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	digestive/alimentary	MP:0005381	9.63	EGF IL13 IL2 IL33 IL4 IL5
2	reproductive system	MP:0005389	9.5	BMP6 EGF IL13 IL2 IL33 IL4
3	respiratory system	MP:0005388	9.1	CCL11 IL13 IL2 IL33 IL4 IL5

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Drugs & Therapeutics for Chronic Asthma

Drugs for Chronic Asthma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 54)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Hormones

Phase 4

Anti-Inflammatory Agents

Phase 4

Hormone Antagonists

Phase 4

Leukotriene Antagonists

Phase 4

Platelet Aggregation Inhibitors

Phase 4

Prasugrel hydrochloride

Phase 4

389574-19-0

Antirheumatic Agents

Phase 4

Analgesics, Non-Narcotic

Phase 4

Anti-Inflammatory Agents, Non-Steroidal

Phase 4

Analgesics

Phase 4

Insulin glargine

Approved

Phase 3

160337-95-1

Zinc

Approved, Investigational

Phase 3

7440-66-6

32051

Atorvastatin

Approved

Phase 2, Phase 3

134523-00-5

60823

Nedocromil

Approved, Investigational

Phase 3

69049-73-6

50294

Levoleucovorin

Approved, Investigational

Phase 3

68538-85-2

149436

Omalizumab

Approved, Investigational

Phase 3

242138-07-4

Methotrexate

Approved

Phase 3

1959-05-2, 59-05-2

126941

Folic acid

Approved, Nutraceutical, Vet_approved

Phase 3

59-30-3

6037

Beclomethasone

Phase 3

4419-39-0

20469

Insulin, Globin Zinc

Phase 3

Hypoglycemic Agents

Phase 3

Insulin, Short-Acting

Phase 3

Insulin, Isophane

Phase 3

Isophane Insulin, Human

Phase 3

insulin

Phase 3

Protamines

Phase 3

Isophane insulin, beef

Phase 3

Methacholine Chloride

Phase 2, Phase 3

Hydroxymethylglutaryl-CoA Reductase Inhibitors

Phase 2, Phase 3

Hypolipidemic Agents

Phase 2, Phase 3

Anticholesteremic Agents

Phase 2, Phase 3

Lipid Regulating Agents

Phase 2, Phase 3

Cromolyn Sodium

Phase 3

Vitamin B Complex

Phase 3

Immunosuppressive Agents

Phase 3

Folic Acid Antagonists

Phase 3

Vitamin B9

Phase 3

Immunologic Factors

Phase 3

Antimetabolites

Phase 3

Folate

Phase 3

mometasone furoate

Approved, Investigational, Vet_approved

Phase 2

83919-23-7

Albuterol

Phase 2

Adrenergic beta-Agonists

Phase 2

Adrenergic Agonists

Phase 2

Neurotransmitter Agents

Phase 2

Tocolytic Agents

Phase 2

Adrenergic Agents

Phase 2

Pharmaceutical Solutions

Phase 2

Phosphodiesterase 4 Inhibitors

Phase 2

Procaterol

Approved, Investigational

Phase 1

72332-33-3

688561

Interventional clinical trials:

(show all 27)

#	Name	Status	NCT ID	Phase	Drugs
1	TEAM (Trial on Efficacy and Quality of Life Among Asthmatic Patient With Montelukast)	Completed	NCT03096327	Phase 4	Montelukast;Placebo
2	The Effect of Prasugrel on Bronchial Hyperreactivity and on Markers of Inflammation in Patients With Chronic Asthma: a Pilot Randomised Controlled Trial (PRINA Study)	Completed	NCT01305369	Phase 4	Prasugrel
3	A Single-Center, Open-Label, Single-Dose Evaluation of the Duration and Extent of Bronchodilation Following Administration of Zileuton CR 1200 mg in Subjects With Stable, Chronic Asthma	Completed	NCT01805687	Phase 4	Zileuton extended release
4	A Multicenter, Randomized, Placebo-Controlled, Double-Blind, 2-Period, Parallel-Group Study to Assess the Clinical Effect of MK0476 With Concomitant Administration of and Removal of Inhaled Beclomethasone in Asthmatic Patients	Completed	NCT00911547	Phase 3	montelukast sodium;beclomethasone;Placebo inhaler;placebo tablet
5	A Multicenter, Randomized, Double-blind, Placebo-Controlled Parallel Group 8-week Study to Evaluate the Efficacy and Safety of Chewable Montelukast When Initiated at the Start of the School Year in Pediatric Patients With Chronic Asthma	Completed	NCT00461032	Phase 3	montelukast;Comparator: Placebo
6	A Multicenter, Double-Blind, Randomized Study Investigating the Clinical Effect of Montelukast on Allergic Rhinitis in Patients With Seasonal Allergic Rhinitis and Chronic Asthma	Completed	NCT00092885	Phase 3	MK0476, montelukast sodium;Comparator: placebo
7	A Multicenter, Randomized, Double-Blind, Parallel-Group 6-Month Study to Evaluate the Efficacy and Safety of Oral Montelukast Sodium, Fluticasone Propionate and Placebo in Patients With Chronic Asthma Who Smoke Cigarettes	Completed	NCT00284856	Phase 3	montelukast sodium;Comparator: Placebo;Comparator: fluticasone;Comparator: Placebo
8	A 24-Week, Double-Blind, Parallel Group, Placebo and Active Controlled Study to Investigate the Efficacy and Safety of Daily Oral Roflumilast Taken With Low Dose Inhaled Corticosteroids in Patients With Chronic Asthma	Completed	NCT00163527	Phase 3	Roflumilast
9	Efficacy and Safety of Inhaled Human Insulin (Exubera) Compared With Subcutaneous Human Insulin in the Therapy of Adult Subjects With Type 1 or Type 2 Diabetes Mellitus and Chronic Asthma: A One-Year, Multicenter, Randomized, Outpatient, Open-Label, Parallel-Group Comparative Trial	Completed	NCT00139659	Phase 3	Inhaled Insulin;Subcutaneous Insulin
10	Randomised Controlled Trial to Evaluate the Effect of Statins on Asthma Control of Patients With Chronic Asthma	Completed	NCT00126048	Phase 2, Phase 3	Atorvastatin;Placebo
11	A Multicenter, Double-Blind, Placebo-Controlled, Randomized, Parallel-Group Study to Evaluate the Clinical Effect of Oral MK0476 Vs Placebo During the Allergy Season in Patients With Seasonal Aeroallergen Sensitivity and Chronic Asthma Which is Also Active During Allergy Season	Completed	NCT00092144	Phase 3	MK0476, montelukast sodium / Duration of Treatment: 4 weeks;Comparator: placebo / Duration of Treatment: 4 weeks
12	A Multicenter, Open-Label, Controlled, Extended Safety Study of Montelukast in Infants and Young Children With Chronic Asthma	Completed	NCT00943397	Phase 3	montelukast sodium;Comparator: Usual Care
13	A Multicenter, Double-Blind, Randomized, Parallel-Group Chronic Asthma Study Comparing Montelukast With Placebo in 2- to 5-Year-Old Patients	Completed	NCT00968201	Phase 3	montelukast sodium;Comparator: Placebo
14	Low-dose Methotrexate for Change in Global Initiative for Asthma Step 5 Medications in Chronic Severe Asthma: a Randomized Controlled Trial	Not yet recruiting	NCT02124226	Phase 3	Methotrexate;Placebo
15	A Phase III Double-Blind, Randomized, Placebo-Controlled Clinical Trial to Prospectively Evaluate Efficacy of Montelukast in Patients Aged 6 Months to 5 Years With Chronic Asthma	Withdrawn	NCT00540839	Phase 3	Montelukast sodium;Placebo to montelukast;Fluticasone propionate;Placebo to fluticasone
16	Randomized, Placebo-controlled Clinical Trial to Study the Efficacy and Safety of Inhaled Corticosteroid Plus Montelukast Compared With Inhaled Corticosteroid Therapy Alone in Patients With Chronic Asthma	Completed	NCT00666679	Phase 2	Comparator: mometasone;Comparator: montelukast;Comparator: placebo (unspecified)
17	A Multicenter, Randomized, Double-Blind, Crossover Study Comparing the Effect of MK0359 and Placebo in Adult Patients With Chronic Asthma	Completed	NCT00482898	Phase 2	MK0359
18	A Multicenter, Randomized, Double Blind, Crossover Study Comparing the Effect of MK0524 With Placebo and Concomitant Administration of MK0524 Plus Montelukast in Adult Patients With Chronic Asthma	Completed	NCT00783601	Phase 2	Comparator: MK0524 + placebo;Comparator: MK0524 + montelukast;Comparator: placebo + montelukast;Comparator: Placebo
19	A Phase II, Randomised, Double Blind, Placebo Controlled, Seven Way Crossover Study to Assess the Effect of Single Doses of RPL554 Compared to Salbutamol and Placebo Administered by Nebuliser on Lung Function of Patients With Chronic Asthma	Completed	NCT02427165	Phase 2	RPL554;Salbutamol;Placebo
20	A Double-Blind, Randomized, Placebo-Controlled, Multicenter, Parallel-Group, Dose-Ranging Study of MK0633 in Adult Patients With Chronic Asthma	Terminated	NCT00404313	Phase 2	MK0633;Comparator: placebo
21	A Phase Ib Randomized, Placebo-Controlled Clinical Trial to Study the Safety and Bronchodilatory Effect of MK0476 in Patients With Chronic Asthma	Completed	NCT00739297	Phase 1	Comparator: montelukast;Comparator: placebo
22	A Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose, Phase I Study to Evaluate the Safety, Tolerability and Pharmacokinetics of Inhaled Laninamivir Octanoate in Adults With Chronic Asthma	Completed	NCT02022761	Phase 1	Laninamivir octanoate
23	Impact of a Pharmaceutical Care Intervention to Improve Adherence of Inhaled Medication in Asthma and COPD Patients	Completed	NCT02386722
24	Montelukast in Chronic Asthma: Non-interventional Study With Montelukast 10 mg	Completed	NCT00802789
25	Effects of Submaximal Regular Physical Exercise on Quality of Life, Symptomatic Control, and Bronchial and Systemic Inflammatory Markers in Patients With Persistent Asthma	Recruiting	NCT04395937
26	Investigation the Safety and Efficacy of The Antileukotriene Agents, Montelukast, as Adjuvant Therapy in Obese Patients With Type 2 Diabetes Mellitus: A Randomized, Controlled Trial	Active, not recruiting	NCT04075110	Early Phase 1	Montelukast 10mg
27	Initiation of Chronic Asthma Care Regimens in the Pediatric Emergency Department	Withdrawn	NCT00388739		Intervention: Budesonide;Usual care: albuterol + systemic steroids

Search NIH Clinical Center for Chronic Asthma

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Genetic Tests for Chronic Asthma

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Anatomical Context for Chronic Asthma

MalaCards organs/tissues related to Chronic Asthma:

⁴⁰

Smooth Muscle, T Cells, Pituitary, Lung, Bronchial Epithelium, Neutrophil, Endothelial

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Publications for Chronic Asthma

Articles related to Chronic Asthma:

(show top 50) (show all 2251)

#	Title	Authors	PMID	Year
1	Mas receptor activation attenuates allergic airway inflammation via inhibiting JNK/CCL2-induced macrophage recruitment. ⁶¹	Hong L...Jiang S	33588264	2021
2	p62-dependent autophagy in airway smooth muscle cells regulates metabolic reprogramming and promotes airway remodeling. ⁶¹	Yu H...Guo X	33310038	2021
3	Pilot study investigating diagnostic utility of serum MMP-1 and TGF-β1 in asthma in 'real world' clinical practice in India. ⁶¹	Prabha A...Mahesh PA	33597224	2021
4	Quantitative analysis of proteome dynamics in a mouse model of asthma. ⁶¹	Funke L...Bracht T	33550702	2021
5	Impact of Technology Based Interventions on Patient Reported Outcomes in Asthma: A Systematic Review. ⁶¹	Doshi H...Jariwala SP	33548519	2021
6	Comparative analysis of the role of mastcells in murine asthma models using Kit-sufficient mast cell-deficient animals. ⁶¹	Pohlmeier L...Tortola L	33559884	2021
7	MicroRNA-21 inhibition attenuates airway inflammation and remodelling by modulating the transforming growth factor β-Smad7 pathway. ⁶¹	Hur J...Kang JY	33601867	2021
8	Acupuncture for chronic persistent asthma based on the theory of Meridian-viscera Association: study protocol for a multi-center randomized controlled trial in China. ⁶¹	Cheng S...Zeng F	33407788	2021
9	Hypoxic hUCMSC-derived extracellular vesicles attenuate allergic airway inflammation and airway remodeling in chronic asthma mice. ⁶¹	Dong L...Mao C	33407872	2021
10	GM-CSF instigates a dendritic cell-T-cell inflammatory circuit that drives chronic asthma development. ⁶¹	Nobs SP...Kopf M	33440200	2021
11	Preventing asthma in high risk kids (PARK) with omalizumab: Design, rationale, methods, lessons learned and adaptation. ⁶¹	Phipatanakul W...PARK Study Team	33242697	2021
12	An enhanced care package to improve asthma management in Malawian children: a randomised controlled trial. ⁶¹	Rylance S...Mortimer K	33479040	2021
13	Characterization of Negative Allosteric Modulators of the Calcium-Sensing Receptor for Repurposing as a Treatment of Asthma. ⁶¹	Yarova PL...Riccardi D	33115824	2021
14	Nephroprotection through Modifying the Apoptotic TNF-α/ERK1/2/Bax Signaling Pathway and Oxidative Stress by Long-term Sodium Hydrosulfide Administration in Ovalbumin-induced Chronic Asthma. ⁶¹	Kianian F...Ranjbaran M	33342312	2020
15	Alteration of Lung and Gut Microbiota in IL-13-Transgenic Mice Simulating Chronic Asthma. ⁶¹	Sohn KH...Kang HR	33046682	2020
16	Role of biomarkers and effect of FIP-fve in acute and chronic animal asthma models. ⁶¹	Wu CT...Lue KH	32778497	2020
17	Protective effects of ascorbic acid and calcitriol combination on airway remodelling in ovalbumin-induced chronic asthma. ⁶¹	Kianian F...Sadeghipour HR	31942829	2020
18	Impact of pneumococcal vaccine response on asthma exacerbation frequency in young children. ⁶¹	Eisenlohr CP...Lanz MJ	32677745	2020
19	Therapeutic efficacy of pulmonary live tuberculosis vaccines against established asthma by subverting local immune environment. ⁶¹	Tarancon R...Aguilo N	33478923	2020
20	Management of Asthma Exacerbations in the Emergency Department. ⁶¹	Hasegawa K...Camargo CA	33387672	2020
21	Fungal sensitization and positive fungal culture from sputum in children with asthma are associated with reduced lung function and acute asthma attacks respectively. ⁶¹	Welsh KG...Gaillard EA	33274520	2020
22	Beyond tobacco - the secondary impact of substance misuse in chronic obstructive lung disease. ⁶¹	Macmurdo M...Zein J	33158365	2020
23	Aryl hydrocarbon receptor deficiency enhanced airway inflammation and remodeling in a murine chronic asthma model. ⁶¹	Chang YD...Lee CC	32959404	2020
24	Asthma Promotes Choroidal Neovascularization via the Transforming Growth Factor beta1/Smad Signaling Pathway in a Mouse Model. ⁶¹	Yang F...Li X	32781454	2020
25	Statins for asthma. ⁶¹	Naing C...Ni H	32668027	2020
26	Residential instability, neighborhood deprivation, and pediatric asthma outcomes. ⁶¹	Molina AL...Oates GR	32275809	2020
27	Nanoparticle-based thymulin gene therapy therapeutically reverses key pathology of experimental allergic asthma. ⁶¹	da Silva AL...Morales MM	32577505	2020
28	Cardiac autonomic modulation assessed by heart rate variability in children with asthma. ⁶¹	Franco OS...Zhang L	32119199	2020
29	Treat to target approach for asthma. ⁶¹	Nannini LJ	30907188	2020
30	Nebulized Inhaled Corticosteroids in Asthma Treatment in Children 5 Years or Younger: A Systematic Review and Global Expert Analysis. ⁶¹	Murphy KR...Pedersen SE	32006721	2020
31	Inducible epithelial resistance against acute Sendai virus infection prevents chronic asthma-like lung disease in mice. ⁶¹	Goldblatt DL...Dickey BF	31968123	2020
32	Treatment with inhaled formulation of angiotensin-(1-7) reverses inflammation and pulmonary remodeling in a model of chronic asthma. ⁶¹	Magalhaes GS...Campagnole-Santos MJ	32517880	2020
33	Qi-Wei-Du-Qi-Wan and its major constituents exert an anti-asthmatic effect by inhibiting mast cell degranulation. ⁶¹	Lin LJ...Kao ST	31751647	2020
34	Parental perception of a picture-based chronic asthma care management tool in an urban pediatric emergency department. ⁶¹	Pade KH...Okelo SO	32249659	2020
35	Evaluation of C-C Chemokine Ligand 5 (CCL5) Chemokine, Interleukin 5 (IL-5) Cytokine, and Eosinophil Counts as Potential Biomarkers in Saudi Patients with Chronic Asthma During Sandstorms. ⁶¹	Alturaiki WH	32467785	2020
36	[Recombinant pyrin domain protein attenuates airway inflammation and airway remodeling through TGF-β1/SMAD and Jagged1/Notch1 signaling pathways in chronic bronchial asthma mice]. ⁶¹	Wang Z...Piao H	32389169	2020
37	Exploratory study of language paediatricians use to promote adherence to long-term controller medication in children with asthma. ⁶¹	Koole T...Brand PLP	32111407	2020
38	Considerations for the Child with Nonatopic Asthma. ⁶¹	Vazquez Garcia G...Blake K	33406019	2020
39	TRPV4 is dispensable for the development of airway allergic asthma. ⁶¹	Palaniyandi S...Rahaman SO	31417159	2020
40	Colony-stimulating factor 1 and its receptor are new potential therapeutic targets for allergic asthma. ⁶¹	Moon HG...Park GY	31385613	2020
41	Lung functional development and asthma trajectories. ⁶¹	Decrue F...Frey U	31989229	2020
42	Inhibition of soluble epoxide hydrolase attenuates airway remodeling in a chronic asthma model. ⁶¹	Jiang JX...Xie QM	31866410	2020
43	Outpatient Management of Chronic Asthma in 2020. ⁶¹	Tripple JW...Calhoun WJ	32044930	2020
44	Icariin alleviates transforming growth factor-β1-induced epithelial-mesenchymal transition by targeting Smad and MAPK signaling pathways. ⁶¹	Li Z...Gao F	32194888	2020
45	Metabolic Adaptation of Airway Smooth Muscle Cells to an SPHK2 Substrate Precedes Cytostasis. ⁶¹	Blais-Lecours P...Marsolais D	31247144	2020
46	Tracheal Adenoid Cystic Carcinoma Presented with Chronic Asthma Diagnosed by Bronchial Washing Cytology. ⁶¹	Mohammadnia M...Mohammadzadeh S	32015749	2020
47	Erratum to "Tetrandrine Ameliorates Airway Remodeling of Chronic Asthma by Interfering TGF-β1/Nrf-2/HO-1 Signaling Pathway-Mediated Oxidative Stress". ⁶¹	Lin Y...Wang Y	32318125	2020
48	Expression of SMARCD1 interacts with age in association with asthma control on inhaled corticosteroid therapy. ⁶¹	McGeachie MJ...Wu AC	31992292	2020
49	Airway Remodeling in Asthma. ⁶¹	Hough KP...Thannickal VJ	32509793	2020
50	Effects of Boldine on Antioxidants and Allied Inflammatory Markers in Mouse Models of Asthma. ⁶¹	Li W...Ma W	32865914	2020

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Genes for Chronic Asthma

Genes related to Chronic Asthma (0 elite genes):

(show all 12)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	IGHE	Immunoglobulin Heavy Constant Epsilon	Protein Coding	7.27	GeneCards inferred via : Publications (show sections)
2	RNASE3	Ribonuclease A Family Member 3	Protein Coding	7.27	GeneCards inferred via : Publications (show sections)
3	IL2	Interleukin 2	Protein Coding	7.06	GeneCards inferred via : Publications (show sections)
4	ALOX5	Arachidonate 5-Lipoxygenase	Protein Coding	6.72	GeneCards inferred via : Publications (show sections)
5	BMP6	Bone Morphogenetic Protein 6	Protein Coding	6.72	GeneCards inferred via : Publications (show sections)
6	CCL11	C-C Motif Chemokine Ligand 11	Protein Coding	6.72	GeneCards inferred via : Publications (show sections)
7	EGF	Epidermal Growth Factor	Protein Coding	6.72	GeneCards inferred via : Publications (show sections)
8	GPT	Glutamic--Pyruvic Transaminase	Protein Coding	6.72	GeneCards inferred via : Publications (show sections)
9	IL13	Interleukin 13	Protein Coding	6.72	GeneCards inferred via : Publications (show sections)
10	IL33	Interleukin 33	Protein Coding	6.72	GeneCards inferred via : Publications (show sections)
11	IL4	Interleukin 4	Protein Coding	6.72	GeneCards inferred via : Publications (show sections)
12	IL5	Interleukin 5	Protein Coding	6.72	GeneCards inferred via : Publications (show sections)

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Variations for Chronic Asthma

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Expression for Chronic Asthma

Search GEO for disease gene expression data for Chronic Asthma.

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Pathways for Chronic Asthma

Pathways related to Chronic Asthma according to GeneCards Suite gene sharing:

(show all 31)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁵ Show member pathways Immune System ⁶⁵ Neutrophil degranulation ⁶⁵	13.85	RNASE3 IL5 IL4 IL33 IL2 IL13
2	ERK Signaling ⁶³ Show member pathways ILK Signaling ⁶³ MAPK Signaling ⁶³ Molecular Mechanisms of Cancer ⁶³ Rho Family GTPases ⁶³	13.66	IL5 IL4 IL2 IL13 EGF CCL11
3	PEDF Induced Signaling ⁶³ Show member pathways all-trans-Retinoic Acid Signaling in Brain ⁶³ Cytokine-cytokine receptor interaction ³⁶ Endothelin-1 Signaling Pathway ⁶³ Glucocorticoid Receptor Signaling ⁶³ IL-6 Pathway ⁶³ MIF Mediated Glucocorticoid Regulation ⁶³ MIF Regulation of Innate Immune Cells ⁶³ NFAT Signaling and Lymphocyte Interactions ⁶³ PGC1Alpha Pathway ⁶³ RAR-Gamma-RXR-Alpha Degradation ⁶³ STAT3 Pathway ⁶³	13.54	IL5 IL4 IL33 IL2 IL13 CCL11
4	TGF-Beta Pathway ⁶³ Show member pathways JAK-STAT Pathway ⁶³ JNK Pathway ⁶³ MAPK Family Pathway ⁶³ Regulation of eIF4 and p70S6K ⁶³ SOCS Pathway ⁶³	13.4	IL5 IL4 IL2 IL13 EGF CCL11
5	Akt Signaling ⁶³ Show member pathways p38 Signaling ⁶³ Tec Kinases Signaling ⁶³	13.28	IL5 IL4 IL2 IL13 EGF CCL11
6	PAK Pathway ⁶³ Show member pathways Antioxidant Action of Vitamin-C ⁶³ Epithelial Adherens Junctions ⁶³	13.16	IL5 IL4 IL2 IL13 EGF CCL11
7	Cytokine Signaling in Immune system ⁶⁵ Show member pathways Signaling by Interleukins ⁶⁵	13.02	IL5 IL4 IL33 IL2 IL13 IGHE
8	Pathways in cancer ³⁶	12.73	IL5 IL4 IL2 IL13 EGF
9	Allograft rejection ³⁶ ¹ Show member pathways Antigen processing and presentation ³⁶ Asthma ³⁶ Autoimmune thyroid disease ³⁶ CTL Mediated Apoptosis ⁶³ Graft-versus-host disease ³⁶ Intestinal immune network for IgA production ³⁶ THC Differentiation Pathway ⁶³ Type I diabetes mellitus ³⁶ Viral myocarditis ³⁶	12.73	RNASE3 IL5 IL4 IL2 IL13 CCL11
10	Immune response Fc epsilon RI pathway ²³ Show member pathways Fc epsilon RI signaling pathway ³⁶ Fc-epsilon receptor I signaling in mast cells ¹ Immune response BCR pathway ²³ VEGF signaling pathway ³⁶	12.5	IL5 IL4 IL13 IGHE ALOX5
11	T cell receptor signaling pathway ³⁶ Show member pathways PD-L1 expression and PD-1 checkpoint pathway in cancer ³⁶ T-Cell antigen Receptor (TCR) Signaling Pathway ¹ T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection ¹	12.48	IL5 IL4 IL2 EGF
12	Th17 cell differentiation ³⁶ Show member pathways IL-22 Pathway ⁶³ Immune response IL-22 signaling pathway ²³ Inflammatory bowel disease ³⁶ Th1 and Th2 cell differentiation ³⁶	12.47	IL5 IL4 IL2 IL13
13	JAK-STAT signaling pathway ³⁶ Show member pathways B-Cell Development ⁶³ IL-7 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types ⁶⁴ Interleukin-19, 20, 22, 24 ⁶⁵ Jak/STAT Signaling Pathway ⁶⁴ Type III interferon signaling ¹	12.33	IL5 IL4 IL2 IL13 EGF
14	IL-17 Family Signaling Pathways ⁶⁴ Show member pathways IL17 signaling pathway ¹ IL-17 signaling pathway ³⁶ Interleukin-17 signaling ⁶⁵ Mucin expression in CF via IL-6, IL-17 signaling pathways ²³	12.24	IL5 IL4 IL13 CCL11
15	Immune response IFN alpha/beta signaling pathway ²³ Show member pathways Cytokine Network ⁶³ Interferon alpha/beta signaling ⁶⁵ Regulation of IFNA signaling ⁶⁵	12.18	IL5 IL4 IL2 IL13 BMP6
16	MAPK Pathway ⁷⁰ Show member pathways Toll-like Receptor Pathway ⁷⁰	11.91	IL5 IL2 IL13
17	Interleukin-4 and 13 signaling ⁶⁵	11.89	IL4 IL13 IGHE CCL11 ALOX5
18	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁴	11.88	IL5 IL4 IL2
19	Glucocorticoid receptor regulatory network ¹	11.74	IL5 IL4 IL2 IL13
20	Calcineurin-regulated NFAT-dependent transcription in lymphocytes ¹ Show member pathways Calcium signaling in the CD4+ TCR pathway ¹	11.68	IL5 IL4 IL2
21	IL4-mediated signaling events ¹	11.58	IL5 IL4 IGHE CCL11
22	Innate Lymphoid Cell Differentiation Pathways ⁶⁴	11.46	IL5 IL4 IL33 IL2 IL13
23	Inflammatory Response Pathway ¹	11.28	IL5 IL4 IL2
24	Development and heterogeneity of the ILC family ¹	11.21	IL5 IL4 IL33 IL13
25	Lung fibrosis ¹	11.15	IL5 IL4 IL13 EGF CCL11
26	Cytokines and Inflammatory Response ¹	11.13	IL5 IL4 IL2 IL13
27	IL12 signaling mediated by STAT4 ¹	11.1	IL2 IL13
28	OX40 Pathway ⁶³	11.04	IL5 IL4 IL2 IL13
29	G-protein signaling_Rap2B regulation pathway ²³	10.9	IL5 IL4 IL2 IL13 EGF CCL11
30	Th2 Differentiation Pathway ⁶⁴	10.76	IL5 IL4 IL33 IL2 IL13 CCL11
31	IL-9 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types ⁶⁴	10.75	IL5 IL4 IL13

Sources

GO Terms for Chronic Asthma

Cellular components related to Chronic Asthma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	9.7	RNASE3 IL5 IL4 IL33 IL2 IL13
2	extracellular space	GO:0005615	9.36	RNASE3 IL5 IL4 IL33 IL2 IL13

Biological processes related to Chronic Asthma according to GeneCards Suite gene sharing:

(show all 22)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of cell proliferation	GO:0008284	9.85	IL5 IL4 IL2 EGF BMP6
2	positive regulation of gene expression	GO:0010628	9.83	IL4 IL33 IL13 EGF BMP6
3	inflammatory response	GO:0006954	9.77	IL5 IL13 CCL11 BMP6 ALOX5
4	positive regulation of peptidyl-tyrosine phosphorylation	GO:0050731	9.72	IL5 EGF BMP6
5	immune response	GO:0006955	9.7	IL5 IL4 IL2 IL13 IGHE CCL11
6	positive regulation of tyrosine phosphorylation of STAT protein	GO:0042531	9.67	IL4 IL2 IL13
7	positive regulation of endothelial cell proliferation	GO:0001938	9.65	EGF CCL11 BMP6
8	negative regulation of inflammatory response	GO:0050728	9.62	IL4 IL2 IL13 ALOX5
9	microglial cell activation	GO:0001774	9.61	IL4 IL13
10	innate immune response in mucosa	GO:0002227	9.6	RNASE3 IL4
11	positive regulation of T cell differentiation	GO:0045582	9.59	IL4 IL2
12	positive regulation of macrophage activation	GO:0043032	9.58	IL33 IL13
13	macrophage activation	GO:0042116	9.58	IL4 IL13
14	positive regulation of MHC class II biosynthetic process	GO:0045348	9.57	IL4 IL33
15	positive regulation of interleukin-13 production	GO:0032736	9.56	IL4 IL33
16	positive regulation of B cell proliferation	GO:0030890	9.56	IL5 IL4 IL2 IL13
17	negative regulation of T-helper 17 cell differentiation	GO:2000320	9.54	IL4 IL2
18	positive regulation of isotype switching to IgG isotypes	GO:0048304	9.52	IL4 IL2
19	positive regulation of mast cell degranulation	GO:0043306	9.51	IL4 IL13
20	negative regulation of complement-dependent cytotoxicity	GO:1903660	9.4	IL4 IL13
21	positive regulation of immunoglobulin production	GO:0002639	9.26	IL5 IL33 IL2 IL13
22	cytokine-mediated signaling pathway	GO:0019221	9.17	IL5 IL4 IL2 IL13 IGHE CCL11

Molecular functions related to Chronic Asthma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	growth factor activity	GO:0008083	9.35	IL5 IL4 IL2 EGF BMP6
2	cytokine activity	GO:0005125	9.17	IL5 IL4 IL33 IL2 IL13 CCL11
3	cytokine receptor binding	GO:0005126	9.16	IL4 IL13

Sources

Sources for Chronic Asthma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 05-Mar-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia