MCID: CHR576
MIFTS: 42

Chronic Beryllium Disease

Categories: Immune diseases, Rare diseases, Respiratory diseases, Skin diseases

Aliases & Classifications for Chronic Beryllium Disease

MalaCards integrated aliases for Chronic Beryllium Disease:

Name: Chronic Beryllium Disease 58
Chronic Berylliosis 58 70
Beryllium Disease, Chronic, Susceptibility to 6
Chronic Beryllium Lung Disease 58
Beryllium Disease Chronic 54
Berylliosis 58

Characteristics:

Orphanet epidemiological data:

58
chronic beryllium disease
Inheritance: Not applicable; Age of onset: Adult; Age of death: elderly;

Classifications:

Orphanet: 58  
Rare respiratory diseases


External Ids:

MESH via Orphanet 45 D001607
ICD10 via Orphanet 33 J63.2
UMLS via Orphanet 71 C0005138 C0221052
Orphanet 58 ORPHA133
UMLS 70 C0221052

Summaries for Chronic Beryllium Disease

MalaCards based summary : Chronic Beryllium Disease, also known as chronic berylliosis, is related to berylliosis and beryllium disease. An important gene associated with Chronic Beryllium Disease is HLA-DPB1 (Major Histocompatibility Complex, Class II, DP Beta 1), and among its related pathways/superpathways are Innate Immune System and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. The drugs Infliximab and Anti-Inflammatory Agents have been mentioned in the context of this disorder. Affiliated tissues include lung, t cells and cortex.

Wikipedia : 73 Berylliosis, or chronic beryllium disease (CBD), is a chronic allergic-type lung response and chronic... more...

Related Diseases for Chronic Beryllium Disease

Diseases in the Beryllium Disease family:

Chronic Beryllium Disease

Diseases related to Chronic Beryllium Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 298)
# Related Disease Score Top Affiliating Genes
1 berylliosis 31.6 IFNG HLA-DRB1 HLA-DPB1
2 beryllium disease 31.0 TNF TGFB1 HLA-DRB1 HLA-DQB1 HLA-DPB1
3 sarcoidosis 1 30.4 TNF IFNG HLA-DRB1 HLA-DQB1
4 pulmonary sarcoidosis 30.4 TNF IFNG
5 lung disease 30.1 TNF TGFB1 IFNG
6 miliary tuberculosis 30.1 TNF IFNG
7 anthracosis 30.1 TNF TGFB1
8 silicosis 30.0 TNF TGFB1 HLA-DQB1
9 exanthem 30.0 TNF IFNG
10 pneumoconiosis 29.8 TNF TGFB1 HLA-DRB1
11 interstitial lung disease 29.5 TNF TGFB1 IFNG
12 rheumatic fever 29.1 TNF IFNG HLA-DRB1 HLA-DQB1
13 inflammatory bowel disease 28.6 TNF TGFB1 IFNG HLA-DRB1 HLA-DQB1
14 allergic disease 10.2
15 pulmonary fibrosis 10.2
16 buerger disease 10.2 HLA-DRB1 HLA-DPB1
17 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.1
18 pneumothorax 10.1
19 systemic onset juvenile idiopathic arthritis 10.1 TNF HLA-DRB1
20 nontuberculous mycobacterial lung disease 10.1 TNF HLA-DRB1
21 myelitis 10.1 TNF HLA-DPB1
22 actinic prurigo 10.1 TNF HLA-DRB1
23 rheumatoid vasculitis 10.1 TNF HLA-DRB1
24 palindromic rheumatism 10.1 TNF HLA-DRB1
25 sympathetic ophthalmia 10.1 TNF HLA-DRB1
26 staphylococcal toxic shock syndrome 10.1 TNF IFNG
27 autoimmune myocarditis 10.1 TNF IFNG
28 spotted fever 10.1 TNF IFNG
29 spotted fever rickettsiosis 10.1 TNF IFNG
30 polyarticular juvenile idiopathic arthritis 10.1 TNF IFNG
31 cicatricial pemphigoid 10.1 HLA-DRB1 HLA-DQB1
32 skeletal tuberculosis 10.1 TNF IFNG
33 chronic inflammatory demyelinating polyradiculoneuropathy 10.1 IFNG HLA-DRB1
34 skin sarcoidosis 10.1 TNF IFNG
35 opportunistic bacterial infectious disease 10.1 TNF IFNG
36 limbic encephalitis with lgi1 antibodies 10.1 HLA-DRB1 HLA-DQB1
37 nocardiosis 10.1 TNF IFNG
38 soft tissue sarcoma 10.1 TNF IFNG
39 gastrointestinal tuberculosis 10.1 TNF IFNG
40 intestinal tuberculosis 10.1 TNF IFNG
41 pharyngitis 10.1 TNF HLA-DRB1
42 oral tuberculosis 10.1 TNF IFNG
43 autoimmune polyglandular syndrome type 3 10.1 HLA-DRB1 HLA-DQB1
44 lymph node tuberculosis 10.1 TNF IFNG
45 idiopathic hypersomnia 10.1 HLA-DRB1 HLA-DQB1
46 orofacial granulomatosis 10.1 TNF IFNG
47 hypersomnia 10.1 HLA-DRB1 HLA-DQB1
48 asbestosis 10.1
49 bronchitis 10.1
50 asbestos intoxication 10.1

Graphical network of the top 20 diseases related to Chronic Beryllium Disease:



Diseases related to Chronic Beryllium Disease

Symptoms & Phenotypes for Chronic Beryllium Disease

Drugs & Therapeutics for Chronic Beryllium Disease

Drugs for Chronic Beryllium Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Infliximab Approved Phase 1, Phase 2 170277-31-3
2 Anti-Inflammatory Agents Phase 1, Phase 2
3 Mesalamine Phase 1, Phase 2 89-57-6
4 Anti-Inflammatory Agents, Non-Steroidal Phase 1, Phase 2
5 Analgesics, Non-Narcotic Phase 1, Phase 2
6 Analgesics Phase 1, Phase 2
7 Antirheumatic Agents Phase 1, Phase 2
8 Gastrointestinal Agents Phase 1, Phase 2
9 Dermatologic Agents Phase 1, Phase 2
10
Heparin Approved, Investigational 9005-49-6 772 9812414
11 Pharmaceutical Solutions
12 calcium heparin

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Targeting Oxidative Stress in Chronic Beryllium Disease Completed NCT01088243 Phase 1, Phase 2 Mesalamine;Placebo
2 Clinical Efficacy of Remicade in Chronic Beryllium Disease: A Randomized, Double-Blind, Placebo-Controlled, Investigator Initiated Trial Terminated NCT00111917 Phase 1, Phase 2 Infliximab
3 The Role of JAK2 in Alveolar Macrophages in Chronic Beryllium Disease Completed NCT02596347
4 Shared Genetic Susceptibility in CBD and Sarcoidosis Completed NCT00560989
5 Exposure in Epigenetic Regulation of Immune Response in Chronic Beryllium Recruiting NCT02604693

Search NIH Clinical Center for Chronic Beryllium Disease

Genetic Tests for Chronic Beryllium Disease

Anatomical Context for Chronic Beryllium Disease

MalaCards organs/tissues related to Chronic Beryllium Disease:

40
Lung, T Cells, Cortex, Lymph Node, Skin, Adrenal Cortex, Bone

Publications for Chronic Beryllium Disease

Articles related to Chronic Beryllium Disease:

(show top 50) (show all 428)
# Title Authors PMID Year
1
Beryllium presentation to CD4+ T cells underlies disease-susceptibility HLA-DP alleles in chronic beryllium disease. 61 6
11050177 2000
2
HLA-DPB1 glutamate 69: a genetic marker of beryllium disease. 6 61
8105536 1993
3
Influence of MHC class II in susceptibility to beryllium sensitization and chronic beryllium disease. 54 61
14662898 2003
4
Nitric oxide attenuates beryllium-induced IFNgamma responses in chronic beryllium disease: evidence for mechanisms independent of IL-18. 61 54
12027422 2002
5
Flow cytometry-based minisequencing: a new platform for high-throughput single-nucleotide polymorphism scoring. 54 61
10860658 2000
6
Differential susceptibilities to chronic beryllium disease contributed by different Glu69 HLA-DPB1 and -DPA1 alleles. 61 54
10415070 1999
7
Beryllium stimulates release of T helper 1 cytokines interleukin-2 and interferon gamma from BAL cells in chronic beryllium disease. 61 54
8598153 1996
8
[Management of occupational health for adverse health effects of beryllium and its compounds in workplaces - Recent trends and issues in Japan]. 61
32788509 2021
9
A Cluster of Beryllium Sensitization Traced to the Presence of Beryllium in Concrete Dust. 61
32926872 2021
10
Beryllium-specific CD4+ T cells induced by chemokine neoantigens perpetuate inflammation. 61
33630763 2021
11
Chronic Beryllium Disease: Update on a Moving Target. 61
32768458 2020
12
Pneumoconiosis with a Sarcoid-Like Reaction Other than Beryllium Exposure: A Case Report and Literature Review. 61
33266389 2020
13
Health aspects of exposure to emissions from burning coal of high beryllium content: interactions with the immune system. 61
32997475 2020
14
Beryllium coordination chemistry and its implications on the understanding of metal induced immune responses. 61
32578609 2020
15
[Diagnostic difficulties of chronic pulmonary berylliosis in France]. 61
32279890 2020
16
A role for TNF-α in alveolar macrophage damage-associated molecular pattern release. 61
32255768 2020
17
Adaptive Immunity in Pulmonary Sarcoidosis and Chronic Beryllium Disease. 61
32256501 2020
18
Lack of an Exposure Response and Interaction With HLA-DPβ1 and DRβ1 Polymorphisms in the Development of Beryllium Toxicity in a High Beryllium Exposure Cohort. 61
31743304 2020
19
Molecular mechanism of Be2+-ion binding to HLA-DP2: tetrahedral coordination, conformational changes and multi-ion binding. 61
31833509 2020
20
Associations of Metrics of Peak Inhalation Exposure and Skin Exposure Indices With Beryllium Sensitization at a Beryllium Manufacturing Facility. 61
31504146 2019
21
Polymorphism of FCGR3A gene in chronic beryllium disease. 61
30245507 2019
22
New insight in beryllium toxicity excluding exposure to beryllium-containing dust: accumulation patterns, target organs, and elimination. 61
30891623 2019
23
Occupational exposure to beryllium in French industries. 61
30570429 2019
24
Interstitial Lung Diseases in Developing Countries. 61
30741505 2019
25
DNA Methylation Changes in Lung Immune Cells Are Associated with Granulomatous Lung Disease. 61
30141971 2019
26
TLR9 and IL-1R1 Promote Mobilization of Pulmonary Dendritic Cells during Beryllium Sensitization. 61
30185516 2018
27
Clinical and laboratory factors contributing to uninterpretable beryllium lymphocyte proliferation tests (BeLPT). 61
29574954 2018
28
[Differential Diagnosis of Mediastinal and Hilar Lymphadenopathy with Focus on Occupational Diseases]. 61
29046010 2018
29
Effect of inhaled corticosteroids on lung function in chronic beryllium disease. 61
29453139 2018
30
Immunologic Effects of Beryllium Exposure. 61
29676647 2018
31
5-Aminosalicylic Acid Modulates the Immune Response in Chronic Beryllium Disease Subjects. 61
29080069 2018
32
Interstitial pneumonia in a glassblower: think to chronic beryllium disease! 61
31011396 2018
33
High-Affinity Interactions of Beryllium(2+) with Phosphatidylserine Result in a Cross-Linking Effect Reducing Surface Recognition of the Lipid. 61
28872302 2017
34
Clinical tool for disease phenotyping in granulomatous lung disease. 61
29145499 2017
35
Occupational Exposure to Beryllium. Final rule. 61
28071878 2017
36
A mortality study of beryllium workers. 61
27766788 2016
37
Chronic Beryllium Disease: The Search for a Dose-Response. 61
27820771 2016
38
Research to Practice Implications of High-Risk Genotypes for Beryllium Sensitization and Disease. 61
27414009 2016
39
Beryllium-induced lung disease exhibits expression profiles similar to sarcoidosis. 61
27103383 2016
40
CpG promoter methylation status is not a prognostic indicator of gene expression in beryllium challenge. 61
26673671 2016
41
Metal-specific CD4+ T-cell responses induced by beryllium exposure in HLA-DP2 transgenic mice. 61
26129650 2016
42
Identification of metal sensitization in sarcoid-like metal-exposed patients by the MELISA® lymphocyte proliferation test - a pilot study. 61
27076838 2016
43
Elemental analysis of occupational granulomatous lung disease by electron probe microanalyzer with wavelength dispersive spectrometer: Two case reports. 61
27330955 2016
44
Gene-environment interaction from international cohorts: impact on development and evolution of occupational and environmental lung and airway disease. 61
26024343 2015
45
Accelerator mass spectrometry detection of beryllium ions in the antigen processing and presentation pathway. 61
24932923 2015
46
Beryllium and other metal-induced lung disease. 61
25602804 2015
47
Genetic susceptibility to beryllium: a case-referent study of men and women of working age with sarcoidosis or other chronic lung disease. 61
25305207 2015
48
The beryllium bronchoalveolar lavage lymphocyte proliferation test: indicator of beryllium sensitization, inflammation or both? 61
25942054 2015
49
Beryllium increases the CD14(dim)CD16+ subset in the lung of chronic beryllium disease. 61
25689051 2015
50
p38 Mitogen-Activated Protein Kinase in beryllium-induced dendritic cell activation. 61
25454621 2014

Variations for Chronic Beryllium Disease

ClinVar genetic disease variations for Chronic Beryllium Disease:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 HLA-DPB1 NM_002121.6(HLA-DPB1):c.292A>G (p.Lys98Glu) SNV risk factor 14904 rs1042140 GRCh37: 6:33048640-33048640
GRCh38: 6:33080863-33080863

Expression for Chronic Beryllium Disease

Search GEO for disease gene expression data for Chronic Beryllium Disease.

Pathways for Chronic Beryllium Disease

Pathways related to Chronic Beryllium Disease according to GeneCards Suite gene sharing:

(show all 45)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.73 TNF TGFB1 IFNG HLA-DRB1 HLA-DQB1 HLA-DPB1
2
Show member pathways
13.54 TNF IFNG HLA-DRB1 HLA-DQB1 HLA-DPB1
3
Show member pathways
13.06 TNF TGFB1 IFNG HLA-DRB1 HLA-DQB1 HLA-DPB1
4
Show member pathways
12.62 TNF IFNG HLA-DRB1 HLA-DQB1 HLA-DPB1
5 12.59 TNF IFNG HLA-DRB1 HLA-DQB1 HLA-DPB1
6
Show member pathways
12.59 TNF TGFB1 IFNG HLA-DRB1 HLA-DQB1 HLA-DPB1
7
Show member pathways
12.45 TNF TGFB1 IFNG
8
Show member pathways
12.41 TNF IFNG HLA-DRB1 HLA-DQB1 HLA-DPB1
9
Show member pathways
12.4 TNF TGFB1 IFNG
10
Show member pathways
12.38 IFNG HLA-DRB1 HLA-DQB1 HLA-DPB1
11
Show member pathways
12.27 TNF TGFB1 IFNG HLA-DRB1 HLA-DQB1 HLA-DPB1
12
Show member pathways
12.19 HLA-DRB1 HLA-DQB1 HLA-DPB1
13 12.14 TNF TGFB1 HLA-DRB1 HLA-DQB1 HLA-DPB1
14
Show member pathways
12.07 HLA-DRB1 HLA-DQB1 HLA-DPB1
15
Show member pathways
12.06 TNF TGFB1 IFNG
16 12.05 TNF TGFB1 IFNG
17 12 HLA-DRB1 HLA-DQB1 HLA-DPB1
18 11.99 HLA-DRB1 HLA-DQB1 HLA-DPB1
19
Show member pathways
11.91 TNF TGFB1 IFNG HLA-DRB1 HLA-DQB1 HLA-DPB1
20 11.89 TNF TGFB1 IFNG
21
Show member pathways
11.84 HLA-DRB1 HLA-DQB1 HLA-DPB1
22 11.81 HLA-DRB1 HLA-DQB1 HLA-DPB1
23 11.8 HLA-DRB1 HLA-DQB1 HLA-DPB1
24 11.8 TNF TGFB1 IFNG
25 11.77 HLA-DRB1 HLA-DQB1 HLA-DPB1
26 11.75 TNF TGFB1 IFNG
27 11.73 TNF HLA-DRB1 HLA-DQB1 HLA-DPB1
28 11.69 TNF TGFB1 IFNG HLA-DRB1 HLA-DQB1 HLA-DPB1
29
Show member pathways
11.67 HLA-DRB1 HLA-DQB1 HLA-DPB1
30
Show member pathways
11.66 TNF TGFB1 IFNG
31 11.64 TNF TGFB1 IFNG
32 11.52 TNF TGFB1 IFNG
33 11.44 TNF TGFB1 IFNG
34 11.42 TNF TGFB1 IFNG
35 11.4 TNF IFNG
36
Show member pathways
11.4 TNF IFNG
37 11.37 TNF IFNG
38 11.33 TNF IFNG
39
Show member pathways
11.28 TNF TGFB1 IFNG
40 11.24 TNF IFNG
41 11.17 TNF IFNG
42 11.15 TGFB1 IFNG HLA-DRB1
43 11.09 TNF TGFB1 IFNG HLA-DRB1
44 11.07 TNF TGFB1 IFNG HLA-DRB1 HLA-DQB1 HLA-DPB1
45 10.8 TNF TGFB1

GO Terms for Chronic Beryllium Disease

Cellular components related to Chronic Beryllium Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.73 TNF TGFB1 HLA-DRB1 HLA-DPB1
2 lysosomal membrane GO:0005765 9.65 HLA-DRB1 HLA-DQB1 HLA-DPB1
3 endosome membrane GO:0010008 9.63 HLA-DRB1 HLA-DQB1 HLA-DPB1
4 trans-Golgi network membrane GO:0032588 9.58 HLA-DRB1 HLA-DQB1 HLA-DPB1
5 endocytic vesicle membrane GO:0030666 9.54 HLA-DRB1 HLA-DQB1 HLA-DPB1
6 ER to Golgi transport vesicle membrane GO:0012507 9.5 HLA-DRB1 HLA-DQB1 HLA-DPB1
7 transport vesicle membrane GO:0030658 9.43 HLA-DRB1 HLA-DQB1 HLA-DPB1
8 clathrin-coated endocytic vesicle membrane GO:0030669 9.33 HLA-DRB1 HLA-DQB1 HLA-DPB1
9 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.13 HLA-DRB1 HLA-DQB1 HLA-DPB1
10 MHC class II protein complex GO:0042613 8.8 HLA-DRB1 HLA-DQB1 HLA-DPB1

Biological processes related to Chronic Beryllium Disease according to GeneCards Suite gene sharing:

(show all 47)
# Name GO ID Score Top Affiliating Genes
1 adaptive immune response GO:0002250 9.85 IFNG HLA-DRB1 HLA-DQB1 HLA-DPB1
2 negative regulation of gene expression GO:0010629 9.83 TNF TGFB1 IFNG
3 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.8 TNF TGFB1 HLA-DRB1
4 T cell receptor signaling pathway GO:0050852 9.77 HLA-DRB1 HLA-DQB1 HLA-DPB1
5 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 9.71 HLA-DRB1 HLA-DQB1 HLA-DPB1
6 positive regulation of MAP kinase activity GO:0043406 9.7 TNF TGFB1
7 positive regulation of protein localization to plasma membrane GO:1903078 9.7 TNF IFNG
8 humoral immune response GO:0006959 9.7 TNF IFNG
9 positive regulation of interleukin-1 beta production GO:0032731 9.69 TNF IFNG
10 positive regulation of cytokine production GO:0001819 9.69 TNF IFNG
11 negative regulation of fat cell differentiation GO:0045599 9.69 TNF TGFB1
12 positive regulation of protein serine/threonine kinase activity GO:0071902 9.68 TGFB1 IFNG
13 positive regulation of phagocytosis GO:0050766 9.68 TNF IFNG
14 negative regulation of blood vessel endothelial cell migration GO:0043537 9.68 TNF TGFB1
15 positive regulation of nitric oxide biosynthetic process GO:0045429 9.68 TNF IFNG
16 negative regulation of T cell proliferation GO:0042130 9.67 TGFB1 HLA-DRB1
17 positive regulation of protein import into nucleus GO:0042307 9.67 TGFB1 IFNG
18 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.67 TNF TGFB1
19 protein kinase B signaling GO:0043491 9.66 TNF TGFB1
20 positive regulation of chemokine production GO:0032722 9.65 TNF IFNG
21 negative regulation of mitotic cell cycle GO:0045930 9.65 TNF TGFB1
22 lipopolysaccharide-mediated signaling pathway GO:0031663 9.65 TNF TGFB1
23 osteoclast differentiation GO:0030316 9.64 TNF TGFB1
24 microglial cell activation GO:0001774 9.64 TNF IFNG
25 negative regulation of interleukin-17 production GO:0032700 9.63 TGFB1 IFNG
26 negative regulation of myoblast differentiation GO:0045662 9.63 TNF TGFB1
27 positive regulation of protein complex assembly GO:0031334 9.63 TNF TGFB1 IFNG
28 positive regulation of osteoclast differentiation GO:0045672 9.62 TNF IFNG
29 macrophage differentiation GO:0030225 9.61 IFNG HLA-DRB1
30 positive regulation of amyloid-beta formation GO:1902004 9.61 TNF IFNG
31 antigen processing and presentation GO:0019882 9.61 HLA-DRB1 HLA-DQB1 HLA-DPB1
32 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.59 TNF IFNG
33 astrocyte activation GO:0048143 9.58 TNF IFNG
34 regulation of regulatory T cell differentiation GO:0045589 9.58 TGFB1 IFNG
35 extrinsic apoptotic signaling pathway GO:0097191 9.58 TNF TGFB1 IFNG
36 negative regulation of production of miRNAs involved in gene silencing by miRNA GO:1903799 9.57 TNF TGFB1
37 negative regulation of amyloid-beta clearance GO:1900222 9.56 TNF IFNG
38 positive regulation of protein phosphorylation GO:0001934 9.56 TNF TGFB1 IFNG HLA-DRB1
39 immune response GO:0006955 9.55 TNF IFNG HLA-DRB1 HLA-DQB1 HLA-DPB1
40 positive regulation of mononuclear cell migration GO:0071677 9.52 TNF TGFB1
41 humoral immune response mediated by circulating immunoglobulin GO:0002455 9.51 HLA-DRB1 HLA-DQB1
42 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.49 TNF IFNG
43 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 9.48 HLA-DRB1 HLA-DQB1
44 positive regulation of vitamin D biosynthetic process GO:0060557 9.37 TNF IFNG
45 positive regulation of nitrogen compound metabolic process GO:0051173 9.32 TNF IFNG
46 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.13 HLA-DRB1 HLA-DQB1 HLA-DPB1
47 interferon-gamma-mediated signaling pathway GO:0060333 8.92 IFNG HLA-DRB1 HLA-DQB1 HLA-DPB1

Molecular functions related to Chronic Beryllium Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.33 TNF TGFB1 IFNG
2 MHC class II receptor activity GO:0032395 8.96 HLA-DRB1 HLA-DQB1
3 peptide antigen binding GO:0042605 8.8 HLA-DRB1 HLA-DQB1 HLA-DPB1

Sources for Chronic Beryllium Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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