MCID: CHR576
MIFTS: 42

Chronic Beryllium Disease

Categories: Immune diseases, Rare diseases, Respiratory diseases, Skin diseases

Aliases & Classifications for Chronic Beryllium Disease

MalaCards integrated aliases for Chronic Beryllium Disease:

Name: Chronic Beryllium Disease 58
Chronic Berylliosis 58 71
Beryllium Disease, Chronic, Susceptibility to 6
Chronic Beryllium Lung Disease 58
Beryllium Disease Chronic 54
Berylliosis 58

Characteristics:

Orphanet epidemiological data:

58
chronic beryllium disease
Inheritance: Not applicable; Age of onset: Adult; Age of death: elderly;

Classifications:

Orphanet: 58  
Rare respiratory diseases


External Ids:

MESH via Orphanet 44 D001607
ICD10 via Orphanet 33 J63.2
UMLS via Orphanet 72 C0005138 C0221052
Orphanet 58 ORPHA133
UMLS 71 C0221052

Summaries for Chronic Beryllium Disease

MalaCards based summary : Chronic Beryllium Disease, also known as chronic berylliosis, is related to berylliosis and beryllium disease. An important gene associated with Chronic Beryllium Disease is HLA-DPB1 (Major Histocompatibility Complex, Class II, DP Beta 1), and among its related pathways/superpathways are Innate Immune System and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. The drugs Infliximab and Anti-Inflammatory Agents have been mentioned in the context of this disorder. Affiliated tissues include lung, t cells and testes.

Wikipedia : 74 Berylliosis, or chronic beryllium disease (CBD), is a chronic allergic-type lung response and chronic... more...

Related Diseases for Chronic Beryllium Disease

Diseases in the Beryllium Disease family:

Chronic Beryllium Disease

Diseases related to Chronic Beryllium Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 250)
# Related Disease Score Top Affiliating Genes
1 berylliosis 31.3 IFNG HLA-DRB1 HLA-DPB1 HLA-DPA1
2 beryllium disease 31.1 TNF HLA-DRB1 HLA-DQB1 HLA-DPB1 HLA-DPA1
3 miliary tuberculosis 30.3 TNF IFNG
4 pulmonary sarcoidosis 30.2 TNF IFNG
5 sarcoidosis 1 30.1 TNF IFNG HLA-DRB1 HLA-DQB1
6 pleural disease 29.7 TNF IFNG
7 autoimmune disease 29.2 TNF IFNG HLA-DRB1 HLA-DQB1
8 rheumatic fever 29.1 TNF IFNG HLA-DRB1 HLA-DQB1
9 inflammatory bowel disease 28.0 TNF IFNG HLA-DRB1 HLA-DQB1 HLA-DPA1
10 lung disease 10.7
11 silicosis 10.6
12 allergic hypersensitivity disease 10.4
13 asbestosis 10.3
14 bronchitis 10.3
15 asbestos intoxication 10.3
16 idiopathic interstitial pneumonia 10.2
17 pulmonary fibrosis 10.2
18 pulmonary hypertension 10.2
19 limbic encephalitis with lgi1 antibodies 10.2 HLA-DRB1 HLA-DQB1
20 autoimmune polyglandular syndrome type 3 10.2 HLA-DRB1 HLA-DQB1
21 primary adrenal insufficiency 10.2 HLA-DRB1 HLA-DQB1
22 hypersomnia 10.2 HLA-DRB1 HLA-DQB1
23 narcolepsy 2 10.2 HLA-DRB1 HLA-DQB1
24 type ii mixed cryoglobulinemia 10.2 HLA-DRB1 HLA-DQB1
25 moyamoya angiopathy 10.2 HLA-DRB1 HLA-DQB1
26 recurrent respiratory papillomatosis 10.2 HLA-DRB1 HLA-DQB1
27 refractory celiac disease 10.2 IFNG HLA-DQB1
28 autoimmune hepatitis type 1 10.2 HLA-DRB1 HLA-DQB1
29 focal epithelial hyperplasia 10.2 HLA-DRB1 HLA-DQB1
30 metal allergy 10.2 HLA-DRB1 HLA-DQB1
31 pediatric multiple sclerosis 10.2 HLA-DRB1 HLA-DQB1
32 osteonecrosis of the jaw 10.2 HLA-DRB1 HLA-DQB1
33 narcolepsy 1 10.2 HLA-DRB1 HLA-DQB1
34 red cell aplasia 10.1 HLA-DRB1 HLA-DQB1
35 pityriasis rosea 10.1 HLA-DRB1 HLA-DQB1
36 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.1
37 pneumoconiosis 10.1
38 anthracosis 10.1
39 pneumothorax 10.1
40 whipple disease 10.1 HLA-DRB1 HLA-DQB1
41 myelitis 10.1 TNF HLA-DPB1
42 ocular cicatricial pemphigoid 10.1 HLA-DRB1 HLA-DQB1
43 cicatricial pemphigoid 10.1 HLA-DRB1 HLA-DQB1
44 paraneoplastic pemphigus 10.1 HLA-DRB1 HLA-DQB1
45 pure red-cell aplasia 10.1 HLA-DRB1 HLA-DQB1
46 acute chest syndrome 10.1 HLA-DRB1 HLA-DQB1
47 cervical dystonia 10.1 HLA-DRB1 HLA-DQB1
48 eosinophilia-myalgia syndrome 10.1 IFNG HLA-DRB1
49 chronic inflammatory demyelinating polyradiculoneuropathy 10.1 IFNG HLA-DRB1
50 polyradiculoneuropathy 10.1 IFNG HLA-DRB1

Graphical network of the top 20 diseases related to Chronic Beryllium Disease:



Diseases related to Chronic Beryllium Disease

Symptoms & Phenotypes for Chronic Beryllium Disease

Drugs & Therapeutics for Chronic Beryllium Disease

Drugs for Chronic Beryllium Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Infliximab Approved Phase 1, Phase 2 170277-31-3
2 Anti-Inflammatory Agents Phase 1, Phase 2
3 Anti-Inflammatory Agents, Non-Steroidal Phase 1, Phase 2
4 Analgesics, Non-Narcotic Phase 1, Phase 2
5 Mesalamine Phase 1, Phase 2 89-57-6
6 Analgesics Phase 1, Phase 2
7 Antirheumatic Agents Phase 1, Phase 2
8 Gastrointestinal Agents Phase 1, Phase 2
9 Dermatologic Agents Phase 1, Phase 2
10
Heparin Approved, Investigational 9005-49-6 772 46507594
11
Acetylcysteine Approved, Investigational 616-91-1 12035
12
Cysteine Approved, Nutraceutical 52-90-4 5862
13 Pharmaceutical Solutions
14 calcium heparin
15 Anti-Infective Agents
16 Respiratory System Agents
17 Free Radical Scavengers
18 Antiviral Agents
19 Antioxidants
20 N-monoacetylcystine
21 Protective Agents
22 Antidotes
23 Expectorants

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Targeting Oxidative Stress in Chronic Beryllium Disease Completed NCT01088243 Phase 1, Phase 2 Mesalamine;Placebo
2 Clinical Efficacy of Remicade in Chronic Beryllium Disease: A Randomized, Double-Blind, Placebo-Controlled, Investigator Initiated Trial Terminated NCT00111917 Phase 1, Phase 2 Infliximab
3 The Role of JAK2 in Alveolar Macrophages in Chronic Beryllium Disease Unknown status NCT02596347
4 Shared Genetic Susceptibility in CBD and Sarcoidosis Completed NCT00560989
5 The Effect of an Oral Antioxidant, N-Acetyl-L-Cysteine, on Inflammatory and Oxidative Stress Markers in Pulmonary Sarcoidosis Completed NCT01587001 Placebo
6 Exposure in Epigenetic Regulation of Immune Response in Chronic Beryllium Recruiting NCT02604693

Search NIH Clinical Center for Chronic Beryllium Disease

Genetic Tests for Chronic Beryllium Disease

Anatomical Context for Chronic Beryllium Disease

MalaCards organs/tissues related to Chronic Beryllium Disease:

40
Lung, T Cells, Testes, Skin, Heart, Monocytes, Cortex

Publications for Chronic Beryllium Disease

Articles related to Chronic Beryllium Disease:

(show top 50) (show all 418)
# Title Authors PMID Year
1
An official American Thoracic Society statement: diagnosis and management of beryllium sensitivity and chronic beryllium disease. 61 6
25398119 2014
2
Beryllium presentation to CD4+ T cells underlies disease-susceptibility HLA-DP alleles in chronic beryllium disease. 61 6
11050177 2000
3
HLA-DPB1 glutamate 69: a genetic marker of beryllium disease. 61 6
8105536 1993
4
Influence of MHC class II in susceptibility to beryllium sensitization and chronic beryllium disease. 54 61
14662898 2003
5
Nitric oxide attenuates beryllium-induced IFNgamma responses in chronic beryllium disease: evidence for mechanisms independent of IL-18. 54 61
12027422 2002
6
Flow cytometry-based minisequencing: a new platform for high-throughput single-nucleotide polymorphism scoring. 54 61
10860658 2000
7
Differential susceptibilities to chronic beryllium disease contributed by different Glu69 HLA-DPB1 and -DPA1 alleles. 54 61
10415070 1999
8
Beryllium stimulates release of T helper 1 cytokines interleukin-2 and interferon gamma from BAL cells in chronic beryllium disease. 54 61
8598153 1996
9
Lack of an Exposure Response and Interaction With HLA-DPβ1 and DRβ1 Polymorphisms in the Development of Beryllium Toxicity in a High Beryllium Exposure Cohort. 61
31743304 2020
10
Molecular mechanism of Be2+-ion binding to HLA-DP2: tetrahedral coordination, conformational changes and multi-ion binding. 61
31833509 2020
11
Associations of Metrics of Peak Inhalation Exposure and Skin Exposure Indices With Beryllium Sensitization at a Beryllium Manufacturing Facility. 61
31504146 2019
12
Polymorphism of FCGR3A gene in chronic beryllium disease. 61
30245507 2019
13
New insight in beryllium toxicity excluding exposure to beryllium-containing dust: accumulation patterns, target organs, and elimination. 61
30891623 2019
14
Occupational exposure to beryllium in French industries. 61
30570429 2019
15
Interstitial Lung Diseases in Developing Countries. 61
30741505 2019
16
DNA Methylation Changes in Lung Immune Cells Are Associated with Granulomatous Lung Disease. 61
30141971 2019
17
TLR9 and IL-1R1 Promote Mobilization of Pulmonary Dendritic Cells during Beryllium Sensitization. 61
30185516 2018
18
Clinical and laboratory factors contributing to uninterpretable beryllium lymphocyte proliferation tests (BeLPT). 61
29574954 2018
19
[Differential Diagnosis of Mediastinal and Hilar Lymphadenopathy with Focus on Occupational Diseases]. 61
29046010 2018
20
Effect of inhaled corticosteroids on lung function in chronic beryllium disease. 61
29453139 2018
21
Immunologic Effects of Beryllium Exposure. 61
29676647 2018
22
5-Aminosalicylic Acid Modulates the Immune Response in Chronic Beryllium Disease Subjects. 61
29080069 2018
23
Interstitial pneumonia in a glassblower: think to chronic beryllium disease! 61
31011396 2018
24
High-Affinity Interactions of Beryllium(2+) with Phosphatidylserine Result in a Cross-Linking Effect Reducing Surface Recognition of the Lipid. 61
28872302 2017
25
Clinical tool for disease phenotyping in granulomatous lung disease. 61
29145499 2017
26
Occupational Exposure to Beryllium. Final rule. 61
28071878 2017
27
A mortality study of beryllium workers. 61
27766788 2016
28
Chronic Beryllium Disease: The Search for a Dose-Response. 61
27820771 2016
29
Research to Practice Implications of High-Risk Genotypes for Beryllium Sensitization and Disease. 61
27414009 2016
30
Beryllium-induced lung disease exhibits expression profiles similar to sarcoidosis. 61
27103383 2016
31
CpG promoter methylation status is not a prognostic indicator of gene expression in beryllium challenge. 61
26673671 2016
32
Metal-specific CD4+ T-cell responses induced by beryllium exposure in HLA-DP2 transgenic mice. 61
26129650 2016
33
Elemental analysis of occupational granulomatous lung disease by electron probe microanalyzer with wavelength dispersive spectrometer: Two case reports. 61
27330955 2016
34
Identification of metal sensitization in sarcoid-like metal-exposed patients by the MELISA® lymphocyte proliferation test - a pilot study. 61
27076838 2016
35
Gene-environment interaction from international cohorts: impact on development and evolution of occupational and environmental lung and airway disease. 61
26024343 2015
36
Accelerator mass spectrometry detection of beryllium ions in the antigen processing and presentation pathway. 61
24932923 2015
37
Beryllium and other metal-induced lung disease. 61
25602804 2015
38
Beryllium increases the CD14(dim)CD16+ subset in the lung of chronic beryllium disease. 61
25689051 2015
39
Genetic susceptibility to beryllium: a case-referent study of men and women of working age with sarcoidosis or other chronic lung disease. 61
25305207 2015
40
The beryllium bronchoalveolar lavage lymphocyte proliferation test: indicator of beryllium sensitization, inflammation or both? 61
25942054 2015
41
p38 Mitogen-Activated Protein Kinase in beryllium-induced dendritic cell activation. 61
25454621 2014
42
Illness absences among beryllium sensitized workers. 61
25211750 2014
43
Quantification and micron-scale imaging of spatial distribution of trace beryllium in shrapnel fragments and metallurgic samples with correlative fluorescence detection method and secondary ion mass spectrometry (SIMS). 61
25146877 2014
44
Beryllium BioBank: 2. Lymphocyte proliferation testing. 61
25099413 2014
45
Beryllium Biobank 3: considerations for improving chronic beryllium disease screening. 61
25099414 2014
46
Exposure factors associated with chronic beryllium disease development in Beryllium BioBank participants. 61
25099412 2014
47
Unsuspected exposure to beryllium: potential implications for sarcoidosis diagnoses. 61
25078645 2014
48
Structural basis of chronic beryllium disease: linking allergic hypersensitivity and autoimmunity. 61
24995984 2014
49
Sarcoidosis and chronic beryllium disease: similarities and differences. 61
25007084 2014
50
Regulatory T cells modulate granulomatous inflammation in an HLA-DP2 transgenic murine model of beryllium-induced disease. 61
24912188 2014

Variations for Chronic Beryllium Disease

ClinVar genetic disease variations for Chronic Beryllium Disease:

6 ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 HLA-DPB1 NM_002121.6(HLA-DPB1):c.292A>G (p.Lys98Glu)SNV risk factor 14904 rs1042140 6:33048640-33048640 6:33080863-33080863

Expression for Chronic Beryllium Disease

Search GEO for disease gene expression data for Chronic Beryllium Disease.

Pathways for Chronic Beryllium Disease

Pathways related to Chronic Beryllium Disease according to GeneCards Suite gene sharing:

(show all 39)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.7 TNF IFNG HLA-DRB1 HLA-DQB1 HLA-DPB1 HLA-DPA1
2
Show member pathways
13.52 TNF IFNG HLA-DRB1 HLA-DQB1 HLA-DPB1 HLA-DPA1
3
Show member pathways
13.14 TNF IFNG HLA-DRB1 HLA-DQB1 HLA-DPB1 HLA-DPA1
4
Show member pathways
13 TNF IFNG HLA-DRB1 HLA-DQB1 HLA-DPA1
5
Show member pathways
12.7 TNF IFNG HLA-DRB1 HLA-DQB1 HLA-DPB1 HLA-DPA1
6
Show member pathways
12.64 TNF IFNG HLA-DRB1 HLA-DQB1 HLA-DPB1 HLA-DPA1
7 12.57 TNF IFNG HLA-DRB1 HLA-DQB1 HLA-DPB1 HLA-DPA1
8
Show member pathways
12.4 IFNG HLA-DRB1 HLA-DQB1 HLA-DPB1 HLA-DPA1
9
Show member pathways
12.4 TNF IFNG HLA-DRB1 HLA-DQB1 HLA-DPB1 HLA-DPA1
10
Show member pathways
12.34 TNF IFNG HLA-DRB1 HLA-DQB1 HLA-DPB1 HLA-DPA1
11
Show member pathways
12.25 HLA-DRB1 HLA-DQB1 HLA-DPB1 HLA-DPA1
12 12.23 TNF HLA-DRB1 HLA-DQB1 HLA-DPB1 HLA-DPA1
13
Show member pathways
12.19 HLA-DRB1 HLA-DQB1 HLA-DPA1
14
Show member pathways
12.14 HLA-DRB1 HLA-DQB1 HLA-DPB1 HLA-DPA1
15 12.07 HLA-DRB1 HLA-DQB1 HLA-DPB1 HLA-DPA1
16 12.04 HLA-DRB1 HLA-DQB1 HLA-DPB1 HLA-DPA1
17
Show member pathways
11.91 TNF IFNG HLA-DRB1 HLA-DQB1 HLA-DPB1 HLA-DPA1
18
Show member pathways
11.89 HLA-DRB1 HLA-DQB1 HLA-DPB1 HLA-DPA1
19 11.86 HLA-DRB1 HLA-DQB1 HLA-DPB1 HLA-DPA1
20 11.85 HLA-DRB1 HLA-DQB1 HLA-DPB1 HLA-DPA1
21 11.81 HLA-DRB1 HLA-DQB1 HLA-DPB1 HLA-DPA1
22
Show member pathways
11.69 HLA-DRB1 HLA-DQB1 HLA-DPB1 HLA-DPA1
23 11.69 TNF IFNG HLA-DRB1 HLA-DQB1 HLA-DPB1 HLA-DPA1
24 11.65 TNF HLA-DRB1 HLA-DQB1 HLA-DPB1 HLA-DPA1
25 11.64 HLA-DRB1 HLA-DQB1 HLA-DPA1
26
Show member pathways
11.48 TNF IFNG
27
Show member pathways
11.46 TNF IFNG
28 11.44 TNF IFNG
29 11.38 TNF IFNG
30 11.36 TNF IFNG
31
Show member pathways
11.36 TNF IFNG
32 11.34 TNF IFNG
33 11.34 TNF IFNG
34 11.3 TNF IFNG
35 11.23 TNF IFNG HLA-DRB1
36 11.21 TNF IFNG
37 11.15 TNF IFNG
38 11.08 IFNG HLA-DRB1
39 11.07 TNF IFNG HLA-DRB1 HLA-DQB1 HLA-DPB1 HLA-DPA1

GO Terms for Chronic Beryllium Disease

Cellular components related to Chronic Beryllium Disease according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.8 TNF HLA-DRB1 HLA-DPB1 HLA-DPA1
2 Golgi membrane GO:0000139 9.78 HLA-DRB1 HLA-DQB1 HLA-DPB1 HLA-DPA1
3 lysosomal membrane GO:0005765 9.76 HLA-DRB1 HLA-DQB1 HLA-DPB1 HLA-DPA1
4 endosome membrane GO:0010008 9.73 HLA-DRB1 HLA-DQB1 HLA-DPB1 HLA-DPA1
5 trans-Golgi network membrane GO:0032588 9.71 HLA-DRB1 HLA-DQB1 HLA-DPB1 HLA-DPA1
6 lysosome GO:0005764 9.69 HLA-DRB1 HLA-DPB1 HLA-DPA1
7 endocytic vesicle membrane GO:0030666 9.67 HLA-DRB1 HLA-DQB1 HLA-DPB1 HLA-DPA1
8 ER to Golgi transport vesicle membrane GO:0012507 9.62 HLA-DRB1 HLA-DQB1 HLA-DPB1 HLA-DPA1
9 transport vesicle membrane GO:0030658 9.56 HLA-DRB1 HLA-DQB1 HLA-DPB1 HLA-DPA1
10 clathrin-coated endocytic vesicle membrane GO:0030669 9.46 HLA-DRB1 HLA-DQB1 HLA-DPB1 HLA-DPA1
11 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.26 HLA-DRB1 HLA-DQB1 HLA-DPB1 HLA-DPA1
12 MHC class II protein complex GO:0042613 8.92 HLA-DRB1 HLA-DQB1 HLA-DPB1 HLA-DPA1

Biological processes related to Chronic Beryllium Disease according to GeneCards Suite gene sharing:

(show all 29)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.87 HLA-DRB1 HLA-DQB1 HLA-DPB1 HLA-DPA1
2 adaptive immune response GO:0002250 9.81 IFNG HLA-DRB1 HLA-DPB1 HLA-DPA1
3 T cell receptor signaling pathway GO:0050852 9.67 HLA-DRB1 HLA-DQB1 HLA-DPB1 HLA-DPA1
4 positive regulation of T cell proliferation GO:0042102 9.64 HLA-DPB1 HLA-DPA1
5 humoral immune response GO:0006959 9.64 TNF IFNG
6 positive regulation of protein localization to plasma membrane GO:1903078 9.63 TNF IFNG
7 positive regulation of phagocytosis GO:0050766 9.63 TNF IFNG
8 positive regulation of interferon-gamma production GO:0032729 9.63 TNF HLA-DPB1 HLA-DPA1
9 immune response GO:0006955 9.63 TNF IFNG HLA-DRB1 HLA-DQB1 HLA-DPB1 HLA-DPA1
10 extrinsic apoptotic signaling pathway GO:0097191 9.62 TNF IFNG
11 positive regulation of nitric oxide biosynthetic process GO:0045429 9.62 TNF IFNG
12 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 9.62 HLA-DRB1 HLA-DQB1 HLA-DPB1 HLA-DPA1
13 positive regulation of protein complex assembly GO:0031334 9.61 TNF IFNG
14 microglial cell activation GO:0001774 9.61 TNF IFNG
15 positive regulation of T cell activation GO:0050870 9.6 HLA-DPB1 HLA-DPA1
16 positive regulation of osteoclast differentiation GO:0045672 9.59 TNF IFNG
17 positive regulation of amyloid-beta formation GO:1902004 9.58 TNF IFNG
18 astrocyte activation GO:0048143 9.58 TNF IFNG
19 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.56 TNF IFNG
20 antigen processing and presentation GO:0019882 9.56 HLA-DRB1 HLA-DQB1 HLA-DPB1 HLA-DPA1
21 positive regulation of chemokine biosynthetic process GO:0045080 9.55 TNF IFNG
22 negative regulation of amyloid-beta clearance GO:1900222 9.54 TNF IFNG
23 humoral immune response mediated by circulating immunoglobulin GO:0002455 9.52 HLA-DRB1 HLA-DQB1
24 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 9.49 HLA-DRB1 HLA-DQB1
25 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.48 TNF IFNG
26 positive regulation of vitamin D biosynthetic process GO:0060557 9.43 TNF IFNG
27 positive regulation of nitrogen compound metabolic process GO:0051173 9.4 TNF IFNG
28 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.26 HLA-DRB1 HLA-DQB1 HLA-DPB1 HLA-DPA1
29 interferon-gamma-mediated signaling pathway GO:0060333 9.02 IFNG HLA-DRB1 HLA-DQB1 HLA-DPB1 HLA-DPA1

Molecular functions related to Chronic Beryllium Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MHC class II receptor activity GO:0032395 9.13 HLA-DRB1 HLA-DQB1 HLA-DPA1
2 peptide antigen binding GO:0042605 8.92 HLA-DRB1 HLA-DQB1 HLA-DPB1 HLA-DPA1

Sources for Chronic Beryllium Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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