MCID: CHR036
MIFTS: 23

Chronic Cholangitis

Categories: Gastrointestinal diseases

Aliases & Classifications for Chronic Cholangitis

MalaCards integrated aliases for Chronic Cholangitis:

Name: Chronic Cholangitis 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:9439
NCIt 50 C35335
SNOMED-CT 68 71912000
UMLS 73 C0267918

Summaries for Chronic Cholangitis

MalaCards based summary : Chronic Cholangitis is related to immunodeficiency 56 and mucinous intrahepatic cholangiocarcinoma. An important gene associated with Chronic Cholangitis is CDX2 (Caudal Type Homeobox 2), and among its related pathways/superpathways are Matrix Metalloproteinases and Transport of vitamins, nucleosides, and related molecules. Affiliated tissues include liver.

Related Diseases for Chronic Cholangitis

Diseases in the Cholangitis family:

Acute Cholangitis Chronic Cholangitis

Diseases related to Chronic Cholangitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 42)
# Related Disease Score Top Affiliating Genes
1 immunodeficiency 56 11.0
2 mucinous intrahepatic cholangiocarcinoma 10.6 CDX2 MUC2
3 ovarian mucinous adenocarcinoma 10.6 CDX2 MUC2
4 ampulla of vater neoplasm 10.6 CDX2 MUC2
5 appendix cancer 10.6 CDX2 MUC2
6 ampulla of vater adenocarcinoma 10.6 CDX2 MUC2
7 biliary papillomatosis 10.5 CDX2 MUC2
8 polyposis, skin pigmentation, alopecia, and fingernail changes 10.5 CDX2 MUC2
9 microinvasive gastric cancer 10.5 CDX2 MUC2
10 superior mesenteric artery syndrome 10.5 CDX2 MUC2
11 ovarian mucinous neoplasm 10.5 CDX2 MUC2
12 cystic teratoma 10.5 CDX2 MUC2
13 biliary tract neoplasm 10.5 CDX2 MUC2
14 duodenum cancer 10.5 CDX2 MUC2
15 hidradenocarcinoma 10.5 CDX2 MUC2
16 pseudomyxoma peritonei 10.5 CDX2 MUC2
17 gastric tubular adenocarcinoma 10.5 CDX2 MUC2
18 signet ring cell adenocarcinoma 10.5 CDX2 MUC2
19 tubular adenocarcinoma 10.4 CDX2 MUC2
20 cystitis cystica 10.4 CDX2 MUC2
21 mucinous adenocarcinoma 10.4 CDX2 MUC2
22 mucinous cystadenocarcinoma 10.4 MUC2 SLCO4A1
23 secretory meningioma 10.4 CDX2 MUC2
24 small intestinal adenocarcinoma 10.4 CDX2 MUC2
25 gastrointestinal system benign neoplasm 10.4 CDX2 MUC2
26 small intestine cancer 10.3 CDX2 MUC2
27 suppurative cholangitis 10.3 CDX2 MUC2
28 intestinal benign neoplasm 10.3 CDX2 MUC2
29 gastric diffuse adenocarcinoma 10.3 CDX2 MMP15
30 colorectal adenocarcinoma 10.2 CDX2 MUC2
31 cholangitis 10.2
32 bile duct carcinoma 10.2 CDX2 MUC2
33 cystadenocarcinoma 10.1 MUC2 SLCO4A1
34 intrahepatic cholangiocarcinoma 10.1 CDX2 MUC2
35 cell type cancer 10.0 CDX2 MUC2
36 hepatitis 9.9
37 cholangitis, primary sclerosing 9.7
38 sclerosing cholangitis 9.7
39 gastrointestinal system cancer 9.7 CDX2 MUC2
40 thrombosis 9.6
41 portal vein thrombosis 9.6
42 congenital hepatic fibrosis 9.6

Graphical network of the top 20 diseases related to Chronic Cholangitis:



Diseases related to Chronic Cholangitis

Symptoms & Phenotypes for Chronic Cholangitis

Drugs & Therapeutics for Chronic Cholangitis

Search Clinical Trials , NIH Clinical Center for Chronic Cholangitis

Genetic Tests for Chronic Cholangitis

Anatomical Context for Chronic Cholangitis

MalaCards organs/tissues related to Chronic Cholangitis:

41
Liver

Publications for Chronic Cholangitis

Articles related to Chronic Cholangitis:

(show all 17)
# Title Authors Year
1
Portal Vein Thrombosis and Arterioportal Shunting Due To Chronic Cholangitis: A Rare Complication of Living-Donor Liver Transplant. ( 26790032 )
2016
2
Enhanced innate immune responsiveness and intolerance to intestinal endotoxins in human biliary epithelial cells contributes to chronic cholangitis. ( 22093333 )
2011
3
Liver: Inappropriate innate immune response to endotoxins contributes to chronic cholangitis. ( 22167869 )
2011
4
Reduced myoelectric activity in the sphincter of Oddi in a new model of chronic cholangitis in rabbits: an in vivo and in vitro study. ( 20426800 )
2010
5
Tumor necrosis factor-alpha induces the aberrant expression of mucus core protein-2 in non-neoplastic biliary epithelial cells via the upregulation of CDX2 in chronic cholangitis. ( 18507686 )
2008
6
Multiple inflammatory-, tissue remodelling- and fibrosis genes are differentially transcribed in the livers of Abcb4 (-/ - ) mice harbouring chronic cholangitis. ( 17852852 )
2007
7
Chronic cholangitis caused by Bordetella hinzii in a liver transplant recipient. ( 15131227 )
2004
8
Life-threatening hemobilia caused by hepatic artery pseudoaneurysm: a rare complication of chronic cholangitis. ( 14669361 )
2003
9
Long-term evaluation of a rat model of chronic cholangitis resembling human primary sclerosing cholangitis. ( 14629625 )
2003
10
Regulation of organic anion transporters in a new rat model of acute and chronic cholangitis resembling human primary sclerosing cholangitis. ( 12044520 )
2002
11
Induction of chronic cholangitis in the rat by trinitrobenzenesulfonic acid. ( 7790710 )
1995
12
Hepatic inflammatory pseudotumor associated with chronic cholangitis: report of three cases. ( 8314264 )
1994
13
Biochemical changes in alpha-naphthyl isothiocyanate-induced chronic cholangitis in the rat. ( 3229462 )
1988
14
Latent chronic cholangitis in congenital hepatic fibrosis. ( 7160410 )
1982
15
Nonsuppurative destructive chronic cholangitis and chronic hepatitis. ( 4908705 )
1970
16
Length of life of an adult after development of completely obliterative chronic cholangitis. ( 14944118 )
1952
17
Chronic cholangitis. ( 20285139 )
1947

Variations for Chronic Cholangitis

Expression for Chronic Cholangitis

Search GEO for disease gene expression data for Chronic Cholangitis.

Pathways for Chronic Cholangitis

GO Terms for Chronic Cholangitis

Cellular components related to Chronic Cholangitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.17 CX3CL1 IL21R MMP15 MUC2 SDC2 SLCO1C1
2 Golgi lumen GO:0005796 8.96 MUC2 SDC2

Biological processes related to Chronic Cholangitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium-independent organic anion transport GO:0043252 8.96 SLCO1C1 SLCO4A1
2 thyroid hormone transport GO:0070327 8.62 SLCO1C1 SLCO4A1

Molecular functions related to Chronic Cholangitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium-independent organic anion transmembrane transporter activity GO:0015347 8.96 SLCO1C1 SLCO4A1
2 thyroid hormone transmembrane transporter activity GO:0015349 8.62 SLCO1C1 SLCO4A1

Sources for Chronic Cholangitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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