MCID: CHR036
MIFTS: 25

Chronic Cholangitis

Categories: Gastrointestinal diseases

Aliases & Classifications for Chronic Cholangitis

MalaCards integrated aliases for Chronic Cholangitis:

Name: Chronic Cholangitis 12 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:9439
NCIt 51 C35335
SNOMED-CT 69 71912000
UMLS 74 C0267918

Summaries for Chronic Cholangitis

MalaCards based summary : Chronic Cholangitis is related to cholangitis and mucinous intrahepatic cholangiocarcinoma. An important gene associated with Chronic Cholangitis is CDX2 (Caudal Type Homeobox 2), and among its related pathways/superpathways are Matrix Metalloproteinases and Transport of vitamins, nucleosides, and related molecules. Affiliated tissues include appendix, liver and skin.

Related Diseases for Chronic Cholangitis

Diseases in the Cholangitis family:

Acute Cholangitis Chronic Cholangitis

Diseases related to Chronic Cholangitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 39)
# Related Disease Score Top Affiliating Genes
1 cholangitis 10.3
2 mucinous intrahepatic cholangiocarcinoma 10.3 CDX2 MUC2
3 intrahepatic cholangiocarcinoma 10.3 CDX2 MUC2
4 duodenum adenocarcinoma 10.3 CDX2 MUC2
5 ovarian mucinous adenocarcinoma 10.3 CDX2 MUC2
6 mucinous adenocarcinoma 10.3 CDX2 MUC2
7 appendix disease 10.3 CDX2 MUC2
8 ampulla of vater adenocarcinoma 10.3 CDX2 MUC2
9 biliary papillomatosis 10.2 CDX2 MUC2
10 polyposis, skin pigmentation, alopecia, and fingernail changes 10.2 CDX2 MUC2
11 superior mesenteric artery syndrome 10.2 CDX2 MUC2
12 ovarian mucinous neoplasm 10.2 CDX2 MUC2
13 appendix cancer 10.2 CDX2 MUC2
14 microinvasive gastric cancer 10.2 CDX2 MUC2
15 cystic teratoma 10.2 CDX2 MUC2
16 duodenum cancer 10.2 CDX2 MUC2
17 hidradenocarcinoma 10.2 CDX2 MUC2
18 pseudomyxoma peritonei 10.2 CDX2 MUC2
19 gastric tubular adenocarcinoma 10.2 CDX2 MUC2
20 tubular adenocarcinoma 10.2 CDX2 MUC2
21 signet ring cell adenocarcinoma 10.2 CDX2 MUC2
22 cystitis cystica 10.2 CDX2 MUC2
23 mucinous cystadenocarcinoma 10.2 MUC2 SLCO4A1
24 ampulla of vater cancer 10.2 CDX2 MUC2
25 suppurative cholangitis 10.2 CDX2 MUC2
26 intestinal benign neoplasm 10.1 CDX2 MUC2
27 bronchiolo-alveolar adenocarcinoma 10.1 CDX2 MUC2
28 gastric diffuse adenocarcinoma 10.1 CDX2 MMP15
29 small intestine cancer 10.1 CDX2 MUC2
30 colorectal adenocarcinoma 10.1 CDX2 MUC2
31 stomach disease 10.0 CDX2 MUC2
32 intestinal disease 10.0 CDX2 MUC2
33 cholangitis, primary sclerosing 9.9
34 sclerosing cholangitis 9.9
35 gastrointestinal system cancer 9.9 CDX2 MUC2
36 hepatitis 9.7
37 thrombosis 9.7
38 portal vein thrombosis 9.7
39 congenital hepatic fibrosis 9.7

Graphical network of the top 20 diseases related to Chronic Cholangitis:



Diseases related to Chronic Cholangitis

Symptoms & Phenotypes for Chronic Cholangitis

Drugs & Therapeutics for Chronic Cholangitis

Search Clinical Trials , NIH Clinical Center for Chronic Cholangitis

Genetic Tests for Chronic Cholangitis

Anatomical Context for Chronic Cholangitis

MalaCards organs/tissues related to Chronic Cholangitis:

42
Appendix, Liver, Skin, Small Intestine

Publications for Chronic Cholangitis

Articles related to Chronic Cholangitis:

(show all 17)
# Title Authors Year
1
Portal Vein Thrombosis and Arterioportal Shunting Due To Chronic Cholangitis: A Rare Complication of Living-Donor Liver Transplant. ( 26790032 )
2017
2
Enhanced innate immune responsiveness and intolerance to intestinal endotoxins in human biliary epithelial cells contributes to chronic cholangitis. ( 22093333 )
2011
3
Liver: Inappropriate innate immune response to endotoxins contributes to chronic cholangitis. ( 22167869 )
2011
4
Reduced myoelectric activity in the sphincter of Oddi in a new model of chronic cholangitis in rabbits: an in vivo and in vitro study. ( 20426800 )
2010
5
Tumor necrosis factor-alpha induces the aberrant expression of mucus core protein-2 in non-neoplastic biliary epithelial cells via the upregulation of CDX2 in chronic cholangitis. ( 18507686 )
2008
6
Multiple inflammatory-, tissue remodelling- and fibrosis genes are differentially transcribed in the livers of Abcb4 (-/ - ) mice harbouring chronic cholangitis. ( 17852852 )
2007
7
Chronic cholangitis caused by Bordetella hinzii in a liver transplant recipient. ( 15131227 )
2004
8
Long-term evaluation of a rat model of chronic cholangitis resembling human primary sclerosing cholangitis. ( 14629625 )
2003
9
Life-threatening hemobilia caused by hepatic artery pseudoaneurysm: a rare complication of chronic cholangitis. ( 14669361 )
2003
10
Regulation of organic anion transporters in a new rat model of acute and chronic cholangitis resembling human primary sclerosing cholangitis. ( 12044520 )
2002
11
Induction of chronic cholangitis in the rat by trinitrobenzenesulfonic acid. ( 7790710 )
1995
12
Hepatic inflammatory pseudotumor associated with chronic cholangitis: report of three cases. ( 8314264 )
1994
13
Biochemical changes in alpha-naphthyl isothiocyanate-induced chronic cholangitis in the rat. ( 3229462 )
1988
14
Latent chronic cholangitis in congenital hepatic fibrosis. ( 7160410 )
1982
15
Nonsuppurative destructive chronic cholangitis and chronic hepatitis. ( 4908705 )
1970
16
Length of life of an adult after development of completely obliterative chronic cholangitis. ( 14944118 )
1952
17
Chronic cholangitis. ( 20285139 )
1947

Variations for Chronic Cholangitis

Expression for Chronic Cholangitis

Search GEO for disease gene expression data for Chronic Cholangitis.

Pathways for Chronic Cholangitis

GO Terms for Chronic Cholangitis

Cellular components related to Chronic Cholangitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.17 CX3CL1 IL21R MMP15 MUC2 SDC2 SLCO1C1
2 Golgi lumen GO:0005796 8.96 MUC2 SDC2

Biological processes related to Chronic Cholangitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium-independent organic anion transport GO:0043252 8.96 SLCO1C1 SLCO4A1
2 thyroid hormone transport GO:0070327 8.62 SLCO1C1 SLCO4A1

Molecular functions related to Chronic Cholangitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium-independent organic anion transmembrane transporter activity GO:0015347 8.96 SLCO1C1 SLCO4A1
2 thyroid hormone transmembrane transporter activity GO:0015349 8.62 SLCO1C1 SLCO4A1

Sources for Chronic Cholangitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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