MCID: CHR036
MIFTS: 24

Chronic Cholangitis

Categories: Gastrointestinal diseases, Immune diseases

Aliases & Classifications for Chronic Cholangitis

MalaCards integrated aliases for Chronic Cholangitis:

Name: Chronic Cholangitis 12 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:9439
NCIt 50 C35335
SNOMED-CT 67 71912000
UMLS 70 C0267918

Summaries for Chronic Cholangitis

MalaCards based summary : Chronic Cholangitis is related to cholangitis and pericholangitis. An important gene associated with Chronic Cholangitis is CDX2 (Caudal Type Homeobox 2). Affiliated tissues include pancreas, liver and smooth muscle.

Related Diseases for Chronic Cholangitis

Diseases in the Cholangitis family:

Autoimmune Cholangitis Acute Cholangitis
Chronic Cholangitis

Diseases related to Chronic Cholangitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 31)
# Related Disease Score Top Affiliating Genes
1 cholangitis 30.9 SP100 DLAT ABCB4
2 pericholangitis 29.8 SLC51A ABCB4
3 cholangitis, primary sclerosing 29.8 SP100 SLC51A DLAT ABCB4
4 biliary tract disease 29.4 SLC51A DLAT CDX2 ABCB4
5 primary biliary cholangitis 29.3 SP100 SLC51A DLAT ABCB4
6 ovarian mucinous adenocarcinoma 10.2 MUC2 CDX2
7 suppurative cholangitis 10.2 DLAT ABCB4
8 pseudomyxoma peritonei 10.2 MUC2 CDX2
9 ampulla of vater adenocarcinoma 10.1 MUC2 CDX2
10 sclerosing cholangitis 10.1
11 autoimmune cholangitis 10.0 SP100 DLAT ABCB4
12 signet ring cell adenocarcinoma 10.0 MUC2 CDX2
13 cholestasis, benign recurrent intrahepatic, 2 10.0 SLC51A ABCB4
14 extrahepatic cholestasis 10.0 SLC51A ABCB4
15 cholestasis, progressive familial intrahepatic, 3 10.0 SLC51A ABCB4
16 cholestasis 9.9
17 tubular adenocarcinoma 9.9 MUC2 CDX2
18 cholestasis, progressive familial intrahepatic, 2 9.9 SLC51A ABCB4
19 cholangiocarcinoma 9.8
20 thrombosis 9.8
21 portal vein thrombosis 9.8
22 choledocholithiasis 9.8
23 ascending cholangitis 9.8
24 acute cholangitis 9.8
25 autoimmune hepatitis 9.8
26 bilirubin metabolic disorder 9.8
27 intrahepatic cholangiocarcinoma 9.8
28 liver cirrhosis 9.8
29 congenital hepatic fibrosis 9.8
30 hypotonia 9.8
31 fanconi-like syndrome 9.7 SLCO4A1 SLCO1C1

Graphical network of the top 20 diseases related to Chronic Cholangitis:



Diseases related to Chronic Cholangitis

Symptoms & Phenotypes for Chronic Cholangitis

Drugs & Therapeutics for Chronic Cholangitis

Search Clinical Trials , NIH Clinical Center for Chronic Cholangitis

Genetic Tests for Chronic Cholangitis

Anatomical Context for Chronic Cholangitis

MalaCards organs/tissues related to Chronic Cholangitis:

40
Pancreas, Liver, Smooth Muscle, Colon, Kidney

Publications for Chronic Cholangitis

Articles related to Chronic Cholangitis:

(show top 50) (show all 134)
# Title Authors PMID Year
1
Suppression of systemic inflammation and signs of acute and chronic cholangitis by multi-kinase inhibitor 1-(4-Cl-benzyl)-3-chloro-4-(CF3-phenylamino)-1H-pyrrole-2,5-dione. 61
33792809 2021
2
Biliary inflammation scoring for immunoglobulin G4-related sclerosing cholangitis: an endoscopic approach with endoscopic ultrasound. 61
33492512 2021
3
The cytologic features of biliary diseases: A retrospective study. 61
32893397 2020
4
Smooth Muscle Distribution Patterns of Choledochal Cysts and Their Implications for Pathogenesis and Postoperative Complications. 61
32010932 2020
5
Effects of Pristine C60 Fullerenes on Liver and Pancreas in α-Naphthylisothiocyanate-Induced Cholangitis. 61
31312992 2020
6
Benign hilar bile duct strictures resected as perihilar cholangiocarcinoma. 61
31386198 2019
7
Toxic effects of VCD on kidneys and liver tissues: a histopathological and biochemical study. 61
31331386 2019
8
Evaluation of the carryover effect of antibiotic, bee pollen and propolis on growth performance, carcass traits and splenic and hepatic histology of growing rabbits. 61
30714248 2019
9
A Young Man with Non-alcoholic Steatohepatitis and Serum Anti-mitochondrial Antibody Positivity. 61
29877264 2018
10
Etiologies, risk factors, and outcomes of bacterial cholangitis after living donor liver transplantation. 61
30039291 2018
11
Coil embolization of ruptured intrahepatic pseudoaneurysm through percutaneous transhepatic biliary drainage. 61
31620580 2018
12
HLA haplotypes in primary sclerosing cholangitis patients of admixed and non-European ancestry. 61
28695657 2017
13
Portal Vein Thrombosis and Arterioportal Shunting Due To Chronic Cholangitis: A Rare Complication of Living-Donor Liver Transplant. 61
26790032 2017
14
Feline Cholangitis. 61
28069287 2017
15
Chronic bovine fasciolosis associated cholangiolithiasis: a case report. 61
28316393 2017
16
Dicrocoelium Dentriticum in Explanted Liver: Report of an Unusual Finding. 61
28260462 2017
17
[Control of Opisthorchis viverrini infection for cholangiocarcinoma prevention]. 61
28105582 2017
18
One case that developed bile duct cancer all over the progress of repeated cholangitis. 61
28070100 2017
19
CRM-1 knockdown inhibits extrahepatic cholangiocarcinoma tumor growth by blocking the nuclear export of p27Kip1. 61
27279267 2016
20
Percutaneous Ultrasound-guided Cholecystocentesis and Bile Analysis for the Detection of Platynosomum spp.-Induced Cholangitis in Cats. 61
27059933 2016
21
PKM2 regulates neural invasion of and predicts poor prognosis for human hilar cholangiocarcinoma. 61
26576639 2015
22
Autophagy and senescence in fibrosing cholangiopathies. 61
25435435 2015
23
Human IL-21 and IL-21R deficiencies: two novel entities of primary immunodeficiency. 61
25321844 2014
24
Cholangiocarcinoma in a middle-aged patient working at a printing plant. 61
25272566 2014
25
Clinicopathological significance of serum fractalkine in primary biliary cirrhosis. 61
23765258 2013
26
Immunopathological study of parasitic cholangitis in cetaceans. 61
23809732 2013
27
Evaluation of a new histologic staging and grading system for primary biliary cirrhosis in comparison with classical systems. 61
23313306 2013
28
Investigation of the roles of fascioliasis and food allergy in intrahepatic eosinophilic proliferative pylephlebitis in Japanese Black cattle. 61
23131780 2013
29
Loss-of-function mutations in the IL-21 receptor gene cause a primary immunodeficiency syndrome. 61
23440042 2013
30
Application and validation of a new histologic staging and grading system for primary biliary cirrhosis. 61
23269312 2013
31
Innate immunity in the pathogenesis of cholangiopathy: a recent update. 61
22920631 2012
32
Bile duct expression of pancreatic and duodenal homeobox 1 in perihilar cholangiocarcinogenesis. 61
22594685 2012
33
Enhanced innate immune responsiveness and intolerance to intestinal endotoxins in human biliary epithelial cells contributes to chronic cholangitis. 61
22093333 2011
34
Liver: Inappropriate innate immune response to endotoxins contributes to chronic cholangitis. 61
22167869 2011
35
Feline cholangitis: a necropsy study of 44 cats (1986-2008). 61
21719332 2011
36
[Diagnostic aspects of chronic cholangitis after cholecystectomy]. 61
22168082 2011
37
Antibiotic prophylaxis for patients undergoing elective endoscopic retrograde cholangiopancreatography. 61
20927758 2010
38
Reduced myoelectric activity in the sphincter of Oddi in a new model of chronic cholangitis in rabbits: an in vivo and in vitro study. 61
20426800 2010
39
Is chronic hepatitis C virus infection a risk factor for breast cancer? 61
20677341 2010
40
Cyst of the common bile duct in a cat. 61
20579033 2010
41
[Pancreatitis as a fatal iatrogenic complication of opisthorchiasis]. 61
20560515 2010
42
Immune tolerance: what is unique about the liver. 61
19717280 2010
43
Autoimmune diseases of the liver and biliary tract and overlap syndromes in childhood. 61
19212308 2009
44
Tumor necrosis factor-alpha induces the aberrant expression of mucus core protein-2 in non-neoplastic biliary epithelial cells via the upregulation of CDX2 in chronic cholangitis. 61
18507686 2008
45
Retrievable biliary stent-graft in the treatment of benign biliary strictures. 61
18662891 2008
46
Biliary complications after duct-to-duct biliary reconstruction in living-donor liver transplantation: causes and treatment. 61
17885788 2007
47
Multiple inflammatory-, tissue remodelling- and fibrosis genes are differentially transcribed in the livers of Abcb4 (-/ - ) mice harbouring chronic cholangitis. 61
17852852 2007
48
Bile duct injuries during laparoscopic cholecystectomy: primary and long-term results from a single institution. 61
17514397 2007
49
Proposal of a new staging and grading system of the liver for primary biliary cirrhosis. 61
17064292 2006
50
Multiple hepatic nodules: rare manifestation of clonorchiasis. 61
16911704 2006

Variations for Chronic Cholangitis

Expression for Chronic Cholangitis

Search GEO for disease gene expression data for Chronic Cholangitis.

Pathways for Chronic Cholangitis

GO Terms for Chronic Cholangitis

Biological processes related to Chronic Cholangitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane transport GO:0055085 9.71 SLCO4A1 SLCO1C1 SLC51A ABCB4
2 monocyte chemotaxis GO:0002548 9.37 CX3CL1 CCL20
3 lymphocyte chemotaxis GO:0048247 9.32 CX3CL1 CCL20
4 bile acid and bile salt transport GO:0015721 9.26 SLCO1C1 SLC51A
5 sodium-independent organic anion transport GO:0043252 9.16 SLCO4A1 SLCO1C1
6 thyroid hormone transport GO:0070327 8.96 SLCO4A1 SLCO1C1
7 bile acid secretion GO:0032782 8.62 SLC51A ABCB4

Molecular functions related to Chronic Cholangitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane transporter activity GO:0022857 9.5 SLCO4A1 SLCO1C1 SLC51A
2 chemokine activity GO:0008009 9.37 CX3CL1 CCL20
3 CCR chemokine receptor binding GO:0048020 9.26 CX3CL1 CCL20
4 sodium-independent organic anion transmembrane transporter activity GO:0015347 9.16 SLCO4A1 SLCO1C1
5 bile acid transmembrane transporter activity GO:0015125 8.96 SLCO1C1 SLC51A
6 thyroid hormone transmembrane transporter activity GO:0015349 8.62 SLCO4A1 SLCO1C1

Sources for Chronic Cholangitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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