Chronic Closed-Angle Glaucoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: CHR054 MIFTS: 33	Chronic Closed-Angle Glaucoma Categories: Eye diseases, Genetic diseases, Neuronal diseases
Genes Tissues Related diseases Publications Symptoms & Phenotypes Drugs Expand all tables

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Aliases & Classifications for Chronic Closed-Angle Glaucoma

MalaCards integrated aliases for Chronic Closed-Angle Glaucoma:

Name: Chronic Closed-Angle Glaucoma ¹² ¹⁵

Anatomical Narrow Angle Glaucoma ¹² ⁷⁰

Chronic Angle-Closure Glaucoma ¹² ⁵⁴

Secondary Angle-Closure Glaucoma - Synechial ⁷⁰

Chronic Narrow Angle Glaucoma ¹²

Classifications:

MalaCards categories:
Global: Genetic diseases
Anatomical: Neuronal diseases Eye diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:14445

ICD9CM ³⁴ 365.23

SNOMED-CT ⁶⁷ 33647009

ICD10 ³² H40.22

UMLS ⁷⁰ C0154947 C1272657

Sources

Summaries for Chronic Closed-Angle Glaucoma

Disease Ontology : ¹² A primary angle-closure glaucoma characterized by chronic and progressive narrowing of the anterior chamber angle by an intrinsic defect such that aqueous outflow is blocked and the intraocular pressure becomes inappropriately elevated leading to optic nerve damage and visual field loss. Chronic closed-angle glaucoma has symptom progressive loss of peripheral vision, decreased vision, and occasionally headaches. Chronic closed-angle glaucoma can be caused by anatomically narrow angle, defects in the trabecular meshwork, and iris abnormalities. Primary angle-closure glaucoma has a strong genetic component.

MalaCards based summary : Chronic Closed-Angle Glaucoma, also known as anatomical narrow angle glaucoma, is related to acute closed-angle glaucoma and intraocular pressure quantitative trait locus, and has symptoms including progressive loss of peripheral vision An important gene associated with Chronic Closed-Angle Glaucoma is TGFB2 (Transforming Growth Factor Beta 2). The drugs Pilocarpine and Travoprost have been mentioned in the context of this disorder. Affiliated tissues include eye and endothelial.

Sources

Related Diseases for Chronic Closed-Angle Glaucoma

Diseases in the Acute Closed-Angle Glaucoma family:

Glaucoma, Primary Closed-Angle

Chronic Closed-Angle Glaucoma

Diseases related to Chronic Closed-Angle Glaucoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 52)

#	Related Disease	Score	Top Affiliating Genes
1	acute closed-angle glaucoma	30.9	TTLL12 MYOC
2	intraocular pressure quantitative trait locus	30.3	TGFB2 MYOC LOXL1 AQP1
3	glaucoma, primary open angle	30.2	TGFB2 MYOC LOXL1 CAV2
4	corneal edema	30.2	MYOC AQP1
5	ocular hypertension	30.1	TGFB2 MYOC
6	nanophthalmos	30.1	MYOC LOXL1 FOXE3
7	cataract	30.1	TGFB2 LOXL1 FOXE3 AQP1
8	open-angle glaucoma	29.8	TGFB2 MYOC LOXL1 CAV2 AQP1
9	primary angle-closure glaucoma	10.5
10	optic nerve disease	10.5
11	myopia	10.3
12	weill-marchesani syndrome	10.2
13	traumatic glaucoma	10.2	MYOC LOXL1
14	steroid-induced glaucoma	10.2	TGFB2 MYOC
15	neovascular glaucoma	10.2	TGFB2 MYOC
16	glaucoma-related pigment dispersion syndrome	10.2	MYOC LOXL1
17	retinal detachment	10.1
18	retinitis pigmentosa	10.1
19	yemenite deaf-blind hypopigmentation syndrome	10.1
20	microvascular complications of diabetes 5	10.1
21	weill-marchesani syndrome 4	10.1
22	microcephaly, epilepsy, and diabetes syndrome	10.1
23	spastic paraplegia, intellectual disability, nystagmus, and obesity	10.1
24	ifap syndrome 2	10.1
25	exudative vitreoretinopathy	10.1
26	brachydactyly	10.1
27	neuroretinitis	10.1
28	lens subluxation	10.1
29	uveitis	10.1
30	retinal vein occlusion	10.1
31	central retinal vein occlusion	10.1
32	phimosis	10.1
33	retinitis	10.1
34	macular retinal edema	10.1
35	eye disease	10.1
36	scotoma	10.1
37	iridocyclitis	10.1
38	refractive error	10.1
39	vitreoretinopathy	10.1
40	phacogenic glaucoma	10.1	TGFB2 MYOC LOXL1
41	bullous keratopathy	10.0	TGFB2 AQP1
42	oculodentodigital dysplasia	10.0	PANX3 PANX2
43	disuse amblyopia	9.9	SPATA31A3 FOXE3
44	heritable thoracic aortic disease	9.9	TGFB2 FOXE3
45	uveal disease	9.9	MYOC LOXL1
46	glaucoma, normal tension	9.9	MYOC LOXL1 CAV2
47	persistent hyperplastic primary vitreous	9.8	TGFB2 FOXE3
48	iris disease	9.8	MYOC LOXL1 FOXE3
49	juvenile glaucoma	9.8	MYOC LOXL1 FOXE3
50	primary congenital glaucoma	9.8	MYOC LOXL1 FOXE3

Comorbidity relations with Chronic Closed-Angle Glaucoma via Phenotypic Disease Network (PDN):

Glaucoma, Primary Open Angle

Hypertension, Essential

Graphical network of the top 20 diseases related to Chronic Closed-Angle Glaucoma:

Sources

Symptoms & Phenotypes for Chronic Closed-Angle Glaucoma

Symptoms:

¹²

• progressive loss of peripheral vision

Sources

Drugs & Therapeutics for Chronic Closed-Angle Glaucoma

Drugs for Chronic Closed-Angle Glaucoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Pilocarpine

Approved, Investigational

Phase 4

54-71-7, 92-13-7

5910

Synonyms:

(+)-Pilocarpine

(3S,4R)-3-ethyl-4-[(1-methyl-1H-imidazol-5-yl)methyl]dihydrofuran-2(3H)-one

(3S,4R)-3-ethyl-4-[(3-methylimidazol-4-yl)methyl]oxolan-2-one

(3S,4R)-3-ethyldihydro-4-((1-methyl-1H-imidazol-5-yl)methyl)-2(3H)-furanone

(3S,4R)-3-Ethyldihydro-4-((1-methyl-1H-imidazol-5-yl)methyl)-2(3H)-furanone

(3S-cis)-3-Ethyldihydro-4-((1-methyl-1H-imidazol-5-yl)methyl)-2(3H)-furanone

(3S-cis)-3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-2(3H)-furanone

(3S-cis)-3-Ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-2(3H)-furanone

3-ethyl-4-((1-methyl-1H-imidazol-5-yl)methyl)dihydro-2(3H)-furanone

3-Ethyl-4-(3-methyl-3H-imidazol-4-ylmethyl)dihydrofuran-2-one

3-Ethyl-4-[(1-methyl-1H-imidazol-5-yl)methyl]dihydro-2(3H)-furanone

3-Ethyl-4-[(1-methyl-1H-imidazol-5-yl)methyl]dihydrofuran-2(3H)-one

3-ethyl-4-[(3-methylimidazol-4-yl)methyl]oxolan-2-one

54-71-7

91484-73-0

92-13-7

AC1L1J0W

AC1L1LEF

AC1Q6MOP

Adsorbocarpine

AI3-50523

Almocarpine

Amistura P

AR-1F3128

beta-Pilocarpine hydrochloride

BIDD:GT0217

BPBio1_000548

BRD-K85090592-008-05-2

BSPBio_000498

BSPBio_002191

C07474

CHEBI:39460

CHEBI:8207

CHEMBL550

CID4819

CID5910

D00525

DB01085

DivK1c_000358

EINECS 202-128-4

Epicar

HMS2089K17

HSDB 3163

Hydrochloride, pilocarpine

IDI1_000358

Imidazole-5-butyric acid, alpha-ethyl-beta-(hydroxymethyl)-1-methyl-, gamma-lactone

isopilocarpine

Isopilocarpine

Isopto carpine

Isoptocarpine

KBio1_000358

KBio2_001587

KBio2_004155

KBio2_006723

KBio3_001691

KBioGR_000956

KBioSS_001587

L001181

Lopac0_000950

Lopac0_000960

LS-187208

LS-7661

Minims Pilocarpine

Miocarpine

Mi-Pilo

MolPort-002-512-506

NCGC00023339-03

NCGC00023339-06

NCGC00023339-07

NCGC00023339-08

NCGC00023339-09

NCGC00023339-12

NCGC00023339-13

nchembio.78-comp9

NCI60_004403

NINDS_000358

Nitrate, pilocarpine

NSC5746

Ocu-Carpine

Ocusert

Ocusert P 20

Ocusert pilo

Ocusert pilo-20

Ocusert pilo-20 (TN)

Ocusert Pilo-40

P.V. Carpine Liquifilm

Pilagan

Pilocarpin

Pilocarpina

pilocarpine

Pilocarpine

Pilocarpine (JAN/USP)

Pilocarpine [USAN:BAN:JAN]

Pilocarpine chloride

Pilocarpine HCl

Pilocarpine HCL

Pilocarpine hydrochloride

Pilocarpine monohydrochloride

Pilocarpine mononitrate, (3S-cis)-isomer

Pilocarpine Mononitrate, (3S-cis)-Isomer

Pilocarpine muriate

Pilocarpine nitrate

Pilocarpine, monohydrochloride, (3S-cis)-isomer

Pilocarpine, Monohydrochloride, (3S-cis)-Isomer

Pilocarpol

Pilokarpin

Pilokarpin monohydrochloride

Pilokarpol

Piloptic-1

Piloptic-1/2

Piloptic-2

Piloptic-3

Piloptic-4

Piloptic-6

Pilostat

Prestwick0_000449

Prestwick1_000449

Prestwick2_000449

Prestwick3_000449

Salagen

SDCCGMLS-0003164.P005

SPBio_001287

SPBio_002437

Spectrum_001107

Spectrum2_001284

Spectrum3_000546

Spectrum4_000478

Spectrum5_001379

Spersacarpine

Spersacarpine hydrochloride

STOCK1N-18408

Syncarpine

Tocris-0694

UNII-01MI4Q9DI3

ZINC00075008

Travoprost

Approved

Phase 4

157283-68-6

5282226

Synonyms:

(((1R)-(1alpha(Z),2beta(1E,3R*),3alpha,5alpha))-7-(3,5-dihydroxy-2-(3-hydroxy-4-(3-trifluoromethyl)phenoxy)-1-butenyl)cyclopentyl)-5-heptenoic acid, 1-methylethyl ester

(+)-Fluprostenol isopropyl ester

(1R-(1alpha(Z),2beta(1E,3R*),3alpha,5alpha))-7-(3,5-Dihydroxy-2-(3-hydroxy-4-(3-(trifluoromethyl)phenoxy)-1-butenyl)cyclopentyl)-5-heptenoic acid, 1-methylethyl ester

(Z)-7-((1R,2R,3R,5S)-3,5-Dihydroxy-2-((1E,3R)-3-hydroxy-4-((alpha,alpha,alpha-trifluoro-m-isopropyl-tolyl)oxy)-1-butenyl)cyclopentyl)-5-heptenoate

157283-68-6

5-Heptenoic acid,7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((1E,3R)-3-hydroxy-4-(3-(trifluoromethyl)phenoxy)-1-butenyl)cyclopentyl)-,1-methylethyl ester,(5Z)

AC1NQZOS

AC-6103

AL6221

AL-6221

C26H35F3O6

CHEBI:746859

CHEMBL1200799

CID5282226

D01964

DB00287

Isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-{(1E,3R)-3-hydroxy-4-[(a,a,a-trifluoro-m-tolyl)oxy]-1-butenyl}cyclopentyl)-5-heptenoate

Isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-{(1E,3R)-3-hydroxy-4-[(a,a,a-trifluoro-m-tolyl)oxy]-1-butenyl}cyclopentyl)-5-heptenoic acid

isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-{(1E,3R)-3-hydroxy-4-[(alpha,alpha,alpha-trifluoro-m-tolyl)oxy]-1-butenyl}cyclopentyl)-5-heptenoate

Isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-{(1E,3R)-3-hydroxy-4-[(alpha,alpha,alpha-trifluoro-m-tolyl)oxy]-1-butenyl}cyclopentyl)-5-heptenoate

Isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-{(1E,3R)-3-hydroxy-4-[(alpha,alpha,alpha-trifluoro-m-tolyl)oxy]-1-butenyl}cyclopentyl)-5-heptenoic acid

isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-{(1E,3R)-3-hydroxy-4-[(α,α,α-trifluoro-m-tolyl)oxy]-1-butenyl}cyclopentyl)-5-heptenoate

Isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-{(1E,3R)-3-hydroxy-4-[(α,α,α-trifluoro-m-tolyl)oxy]-1-butenyl}cyclopentyl)-5-heptenoate

Isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-{(1E,3R)-3-hydroxy-4-[(α,α,α-trifluoro-m-tolyl)oxy]-1-butenyl}cyclopentyl)-5-heptenoic acid

LS-173521

propan-2-yl (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-{(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-en-1-yl}cyclopentyl]hept-5-enoate

propan-2-yl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-enyl]cyclopentyl]hept-5-enoate

S1554_Selleck

Travatan

Travatan (TN)

Travatan Alcon

Travatan Z

Travatan, Travoprost

Travatanz

Travoprost

Travoprost (JAN/USAN/INN)

Travoprost [USAN]

Travoprostum

Z, Travatan

ZINC04474682

Brinzolamide

Approved

Phase 4

138890-62-7

68844

Synonyms:

(+)-4-ETHYLAMINO-3,4-DIHYDRO-2-(METHOXY)PROPYL-2H-THIENO[3,2-E]-1,2-THIAZINE-6-SULFONAMIDE-1,1-DIOXIDE

(4R)-4-(ethylamino)-2-(3-methoxypropyl)-1,1-dioxo-3,4-dihydrothieno[3,2-e]thiazine-6-sulfonamide

(4R)-4-(ethylamino)-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide

(R)-4-(ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-2H-thieno(3,2-e)-1,2-thiazine-6-sulfonamide

(R)-4-(Ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-2H-thieno(3,2-e)-1,2-thiazine-6-sulfonamide 1,1-dioxide

138890-62-7

2H-Thieno(3,2-e)-1,2-thiazine-6-sulfonamide,4-(ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-,1,1-dioxide,R

3znc

AB00513824

AC1L2AKA

AC1Q6UVB

AC-5277

AKOS005145708

AL 4862

AL04862

AL-4862

Alcon brand of brinzolamide

Alcon brand OF brinzolamide

Allphar brand of brinzolamide

Allphar brand OF brinzolamide

Azopt

Azopt (TN)

BIDD:GT0039

Birnzolamide

BPBio1_000539

BRD-K74913225-001-03-3

Brinzolamida

Brinzolamide

Brinzolamide (BRZ)

Brinzolamide (JAN/USP/INN)

Brinzolamide [USAN]

BSPBio_000489

BZ1

C07760

C111827

C12H21N3O5S3

CHEBI:3176

CHEMBL220491

CID68844

D00652

DB01194

FT-0082471

HMS1569I11

I09-0605

LS-173036

MLS002153787

MolPort-005-940-291

Prestwick0_000365

Prestwick1_000365

Prestwick2_000365

Prestwick3_000365

SMR001233169

SPBio_002410

UNII-9451Z89515

Neurotransmitter Agents

Phase 4

Muscarinic Agonists

Phase 4

Cholinergic Agents

Phase 4

Antihypertensive Agents

Phase 4

Carbonic Anhydrase Inhibitors

Phase 4

Latanoprost

Approved, Investigational

Phase 3

130209-82-4

5282380 5311221

Synonyms:

130209-82-4

AC1NSK8Q

Ambap130209-82-4

AR-202

Catioprost

CHEBI:6384

CHEMBL1051

CID5311221

CPD000466354

D00356

HMS2051H11

HMS2089J17

isopropyl (5Z,9alpha,11alpha,15R)-9,11,15-trihydroxy-17-phenyl-18,19,20-trinorprost-5-en-1-oate

Isopropyl (5Z,9alpha,11alpha,15R)-9,11,15-trihydroxy-17-phenyl-18,19,20-trinor-prost-5-en-1-oate

isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((3R)-3-hydroxy-5-phenylpentyl)cyclopentyl)-5-heptenoate

Isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((3R)-3-hydroxy-5-phenylpentyl)cyclopentyl)-5-heptenoate

Isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((3R)-3-hydroxy-5-phenylpentyl)cyclopentyl)-5-heptenoic acid

Jsp001835

L1167_SIGMA

latanoprost

Latanoprost

Latanoprost (JAN/USAN/INN)

latanoprost free acid

Latanoprostum

MLS000759468

MLS001424106

MolPort-003-942-862

Nova-21027

Pfizer brand OF latanoprost

PhXA 41

PhXA34

PhXA34 [as 15(R,S)-isomer]

PhXA41

PHXA41

PHXA-41

propan-2-yl (5Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl}hept-5-enoate

Propan-2-yl (5Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl}hept-5-enoate

Propan-2-yl (5Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl}hept-5-enoic acid

propan-2-yl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]hept-5-enoate

S1254_Selleck

SAM001246671

SMR000466354

TL8000716

XA41

XA-41

Xalatan

Xalatan (TN)

Xalatan Fixed Flow Device

ZINC12468792

Pharmaceutical Solutions

Phase 2

Ophthalmic Solutions

Phase 2

Bimatoprost

Approved, Investigational

155206-00-1

5311027

Synonyms:

(5Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-5-phenylpent-1-en-1-yl]cyclopentyl}-N-ethylhept-5-enamide

(Z)-7-((1R,2R,3R,5S)-3,5-Dihydroxy-2-((1E,3S)-3-hydroxy-5-phenyl-1-pentenyl)cyclopentyl)-N-ethyl-5-heptenamide

(Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-hydroxy-5-phenylpent-1-enyl]cyclopentyl]-N-ethylhept-5-enamide

155206-00-1

15M

267244-98-4

5-Heptenamide,7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((1E,3S)-3-hydroxy-5-phenyl-1-pentenyl)cyclopentyl)-N-ehtyl-,(5Z)

AC1NSJUW

AGN 192024

AGN-192024

Bimataprost [USAN:INN:BAN]

Bimatoprost

Bimatoprost (JAN/USAN/INN)

Bimatoprost [USAN:INN:BAN]

bimatoprostum

Bimatoprostum

CHEBI:39562

CHEBI:51230

CHEMBL1200963

CID5311027

D02724

DB00905

DB06863

I06-1275

I06-1277

Latisse

LS-181817

Lumigan

Lumigan (TN)

NCGC00181745-01

UNII-QXS94885MZ

ZINC04474405

Mitomycins

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	A Twelve-Week, Double Masked, Parallel Group, Primary-Therapy Pilot Study of the Safety and Efficacy of Travoprost 0.004% Compared to Pilocarpine 1% in Patients With Chronic Angle-Closure Glaucoma	Completed	NCT00762645	Phase 4	Travoprost 0.004% (Travatan);Pilocarpine 1%
2	A Double-Masked, Parallel-Group, Efficacy and Safety Study of Brinzolamide 1.0% (AZOPT) as Adjunctive Therapy to Travoprost 0.004% (TRAVATAN) in Patients With Chronic Angle-Closure Glaucoma	Terminated	NCT00758342	Phase 4	Travoprost 0.004% + Brinzolamide 1.0%;Travoprost 0.004% + Tears Natural
3	A Safety and Efficacy Study of Travoprost 0.004% Compared to Latanoprost 0.005% in Patients With Chronic Angle-Closure Glaucoma.	Completed	NCT00051181	Phase 3	Travoprost (0.004%);Latanoprost (0.005%)
4	A Prospective Study to Assess the Hypotensive Efficacy of Rho-Kinase Inhibitor AR-12286 Ophthalmic Solution 0.5% and 0.7% in Patients With Chronic Angle-closure Glaucoma	Unknown status	NCT02152774	Phase 2	Rho-Kinase Inhibitor
5	Prevalence of Chronic Angle Closure in Caucasian Hyperopic Subjects	Unknown status	NCT00823706
6	Comparison of Bimatoprost and Lataprost in Patients With Chronic Angle-Closure Glaucoma: A Randomized Cross-Over Study	Unknown status	NCT00567788		Latanoprost-Bimatoprost;Bimatoporost-Latanoprost
7	Sequential Laser Iridotomy Using Argon and Q-Switched 532 nm Frequency Doubled Neodymium Yag Laser: A Pilot Study	Completed	NCT00452998
8	Phacoemulsification Combined With Trabeculectomy Versus Phacoemulsification Combined With Trabeculotomy for Treatment of Chronic Angle Closure Glaucoma	Recruiting	NCT04683055

Search NIH Clinical Center for Chronic Closed-Angle Glaucoma

Sources

Genetic Tests for Chronic Closed-Angle Glaucoma

Sources

Anatomical Context for Chronic Closed-Angle Glaucoma

MalaCards organs/tissues related to Chronic Closed-Angle Glaucoma:

⁴⁰

Eye, Endothelial

Sources

Publications for Chronic Closed-Angle Glaucoma

Articles related to Chronic Closed-Angle Glaucoma:

(show top 50) (show all 331)

#	Title	Authors	PMID	Year
1	A phase III study of subconjunctival human anti-transforming growth factor beta(2) monoclonal antibody (CAT-152) to prevent scarring after first-time trabeculectomy. ⁵⁴ ⁶¹	CAT-152 0102 Trabeculectomy Study Group...Smith Z	17908591	2007
2	Laser peripheral iridoplasty for chronic angle closure. ⁶¹	Bayliss JM...Azuara-Blanco A	33755197	2021
3	Lens extraction for chronic angle-closure glaucoma. ⁶¹	Ong AY...Friedman DS	33759192	2021
4	Outcomes of Small Size Ahmed Glaucoma Valve Implantation in Asian Chronic Angle-Closure Glaucoma. ⁶¹	Huang KH...Chen YH	33671383	2021
5	Postoperative complicated peripheral cortical cataract after ultrasound cycloplasty: a case report. ⁶¹	Luo J...Sun Y	33413166	2021
6	Outcomes of combined gonioscopy-assisted transluminal trabeculotomy and goniosynechialysis in primary angle closure: a retrospective case series. ⁶¹	Chira-Adisai T...Kinoshita S	33392940	2021
7	Bilateral Ocular Ischemic Syndrome in the Setting of Chronic Angle Closure Glaucoma. ⁶¹	Naravane AV...Lee MS	33394841	2020
8	Profiles and Clinical Characteristics of Newly Diagnosed Glaucoma in Urban Korea: A Multicenter Study. ⁶¹	Hong C...Kim CS	33099556	2020
9	Influence of automated visual field testing on intraocular pressure. ⁶¹	Bertaud S...Labbe A	32907553	2020
10	Early results of micropulse transscleral cyclophotocoagulation for the treatment of glaucoma. ⁶¹	Nguyen AT...Noecker RJ	30938190	2020
11	The Effectiveness and Safety of Micropulse Cyclophotocoagulation in the Treatment of Ocular Hypertension and Glaucoma. ⁶¹	Kaba Q...Yuen D	32672613	2020
12	MicroPulse Transscleral Laser Therapy with Kahook Dual Blade Excisional Goniotomy and Goniosynechialysis Combined with Phacoemulsification for Angle-Closure Glaucoma: A Case Report. ⁶¹	Al Habash A...Khoueir Z	33223857	2020
13	Iridoschisis: visual outcome in treated versus untreated eye. ⁶¹	Ruff E...Dersu I	32884893	2020
14	Aqueous humor levels of TGFβ2 and SFRP1 in different types of glaucoma. ⁶¹	Guo T...Fan X	31382918	2019
15	Differential Efficacy of Combined Phacoemulsification and Endocyclophotocoagulation in Open-angle Glaucoma Versus Angle-closure Glaucoma. ⁶¹	Lin MM...Chen TC	30839415	2019
16	Anterior Segment Features in Nanophthalmos With Secondary Chronic Angle Closure Glaucoma: An Ultrasound Biomicroscopy Study. ⁶¹	Guo C...Fan Z	31112609	2019
17	Surgical outcomes of phacoemulsification/goniosynechialysis with and without endocyclophotocoagulation in patients with chronic angle closure glaucoma. ⁶¹	Panse K...Ayyala RS	30777954	2019
18	Indicating and predicting role of the horizontal C/D ratio in preclinical diabetic retinopathy associated with chronic angle-closure glaucoma. ⁶¹	Zhong ZL...Chen S	30809483	2019
19	Post-miosis changes in the anterior chamber structures in primary and lens-induced secondary chronic angle-closure glaucoma. ⁶¹	Li M...Zhang H	31024825	2019
20	Primary Outcomes of Patients with Chronic Angle-Closure Glaucoma Treated with Combined Phacoemulsification, Viscogoniosynechialysis, and Endocyclophotocoagulation. ⁶¹	Izquierdo Villavicencio JC...Mejias Smith J	31312531	2019
21	RETINAL AND CHOROIDAL VASCULAR OCCLUSION FOLLOWING AQUEOUS MISDIRECTION SYNDROME IN A PATIENT WITH SICKLE CELL TRAIT. ⁶¹	Dewundara S...Abrams GW	28489705	2019
22	Cypass Supraciliary Stent in Eye With Chronic Angle Closure and Postvitrectomy With Silicone Oil. ⁶¹	Hopen ML...Gallardo MJ	29979341	2018
23	Angle-closure Glaucoma in a Myopic Patient Precipitated by Sexual Excitation: A Case Report. ⁶¹	Popovic M...Schlenker MB	31354207	2018
24	Profile and management outcomes of glaucoma cases at Qassim University Hospital. ⁶¹	Alzuhairy S...Mousa A	30202404	2018
25	Factors Associated with Outcomes of Combined Phacoemulsification and Ahmed Glaucoma Valve Implantation. ⁶¹	Kwon J...Sung KR	29770636	2018
26	Retinal pigment epithelium changes in Kartagener syndrome. ⁶¹	Garcia MD...Berrocal AM	29511746	2018
27	Long-term outcomes after acute primary angle closure of Caucasian chronic angle closure glaucoma patients. ⁶¹	Fea AM...Aung T	28722309	2018
28	Macular Choroidal Small-Vessel Layer, Sattler's Layer and Haller's Layer Thicknesses: The Beijing Eye Study. ⁶¹	Zhao J...Jonas JB	29535365	2018
29	Refractive outcomes of phacoemulsification cataract surgery in glaucoma patients. ⁶¹	Manoharan N...Seibold LK	29605284	2018
30	Visual Subfield Progression in Glaucoma Subtypes. ⁶¹	Su WW...Chen HS	29750123	2018
31	Longitudinal Change in Peripheral Anterior Chamber Depth of Eyes with Angle Closure after Laser Iridotomy. ⁶¹	Furuya T...Kashiwagi K	30671261	2018
32	Ocular pulse amplitude in different types of glaucoma using dynamic contour tonometry: Diagnosis and follow-up of glaucoma. ⁶¹	Cheng L...Wu Z	29104631	2017
33	Optic Nerve Head Characteristics in Chronic Angle Closure Glaucoma Detected by Swept-Source OCT. ⁶¹	Li D...Shen LQ	28922031	2017
34	Long-term scanning laser ophthalmoscopy and perimetry in different severities of primary open and chronic angle closure glaucoma eyes. ⁶¹	Sihota R...Kalaiwani M	29044061	2017
35	Acute hypotony maculopathy following the initiation of a topical aqueous suppressant in a patient with a history of panuveitis without prior filtering surgery. ⁶¹	Zhu D...Rao NA	29260088	2017
36	Intraoperative Optical Coherence Tomography-Assisted Descemet Stripping Automated Endothelial Keratoplasty for Anterior Chamber Fibrous Ingrowth. ⁶¹	Shazly TA...Espandar L	28399038	2017
37	High intensity focused ultrasound as first line treatment in patients with chronic angle closure glaucoma at risk for malignant glaucoma. ⁶¹	Graber M...Lachkar Y	28342558	2017
38	Analyzing cytokines as biomarkers to evaluate severity of glaucoma. ⁶¹	Tong Y...Wang ZY	28730084	2017
39	Peripapillary retinal splitting visualized on OCT in glaucoma and glaucoma suspect patients. ⁶¹	Grewal DS...Tanna AP	28832670	2017
40	Bilateral Same-day Laser Peripheral Iridotomy in the Philadelphia Glaucoma Detection and Treatment Project. ⁶¹	Waisbourd M...Katz LJ	26950579	2016
41	Pupillary block due to reverse implantation of a sulcus intraocular lens. ⁶¹	Zhang X...Saeedi O	28184333	2016
42	Intraoperative floppy-iris syndrome associated with use of antipsychotic drugs. ⁶¹	Matsuo M...Tanito M	27521670	2016
43	Risk Factors of Disease Progression After Cataract Surgery in Chronic Angle-closure Glaucoma Patients. ⁶¹	Lee CK...Kim CY	26550967	2016
44	Efficacy and Safety of Trabectome Surgery in Chinese Open-Angle Glaucoma. ⁶¹	Lee JWY...Lai JSM	27082559	2016
45	The Frequency of Optical Coherence Tomography Testing in Glaucoma at a Single Academic Medical Center. ⁶¹	Griffith JF...Goldberg JL	26372155	2016
46	Endoscopic Cyclophotocoagulation and Pars Plana Ablation (ECP-plus) to Treat Refractory Glaucoma. ⁶¹	Tan JC...Chopra V	26020690	2016
47	The effect of adjustable suture (Khaw) trabeculectomy on intraocular pressure: a retrospective case series. ⁶¹	Kaplan A...Dayanir V	26002838	2016
48	Case report: imaging and treatment of ophthalmic manifestations in oculodentodigital dysplasia. ⁶¹	Mosaed S...Lin KY	26743931	2016
49	Comparison of phacotrabeculectomy and sequential surgery in the treatment of chronic angle-closure glaucoma coexisted with cataract. ⁶¹	Li HJ...Xie L	27275422	2016
50	The safety and efficacy of modified minimally invasive trabeculectomy for the treatment of primary chronic angle-closure glaucoma. ⁶¹	Wu Z...Ma D	27215005	2015

Sources

Genes for Chronic Closed-Angle Glaucoma

Genes related to Chronic Closed-Angle Glaucoma (0 elite genes):

(show all 12)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	TGFB2	Transforming Growth Factor Beta 2	Protein Coding	12.32	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	17908591
2	SPATA31A3	SPATA31 Subfamily A Member 3	Protein Coding	5.86	DISEASES inferred ¹⁵
3	MYOC	Myocilin	Protein Coding	5.47	DISEASES inferred ¹⁵
4	LOXL1	Lysyl Oxidase Like 1	Protein Coding	5.4	DISEASES inferred ¹⁵
5	IZUMO2	IZUMO Family Member 2	Protein Coding	5.06	DISEASES inferred ¹⁵
6	CYLC2	Cylicin 2	Protein Coding	4.98	DISEASES inferred ¹⁵
7	PANX3	Pannexin 3	Protein Coding	4.96	DISEASES inferred ¹⁵
8	PANX2	Pannexin 2	Protein Coding	4.87	DISEASES inferred ¹⁵
9	AQP1	Aquaporin 1 (Colton Blood Group)	Protein Coding	4.83	DISEASES inferred ¹⁵
10	CAV2	Caveolin 2	Protein Coding	4.71	DISEASES inferred ¹⁵
11	FOXE3	Forkhead Box E3	Protein Coding	4.67	DISEASES inferred ¹⁵
12	TTLL12	Tubulin Tyrosine Ligase Like 12	Protein Coding	4.65	DISEASES inferred ¹⁵

Sources

Variations for Chronic Closed-Angle Glaucoma

Sources

Expression for Chronic Closed-Angle Glaucoma

Search GEO for disease gene expression data for Chronic Closed-Angle Glaucoma.

Sources

Pathways for Chronic Closed-Angle Glaucoma

Sources

GO Terms for Chronic Closed-Angle Glaucoma

Cellular components related to Chronic Closed-Angle Glaucoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	gap junction	GO:0005921	8.62	PANX3 PANX2

Biological processes related to Chronic Closed-Angle Glaucoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	collagen fibril organization	GO:0030199	9.26	TGFB2 LOXL1
2	eye development	GO:0001654	9.16	TGFB2 FOXE3
3	odontogenesis	GO:0042476	8.96	TGFB2 AQP1
4	positive regulation of interleukin-1 production	GO:0032732	8.62	PANX3 PANX2

Molecular functions related to Chronic Closed-Angle Glaucoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	gap junction hemi-channel activity	GO:0055077	9.16	PANX3 PANX2
2	wide pore channel activity	GO:0022829	8.96	PANX3 PANX2
3	channel activity	GO:0015267	8.8	PANX3 PANX2 AQP1

Sources

Sources for Chronic Closed-Angle Glaucoma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 05-Apr-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ Tocris

⁷⁰ UMLS

⁷¹ UMLS via Orphanet

⁷² UniProtKB/Swiss-Prot

⁷³ Wikipedia