MCID: CHR054
MIFTS: 42

Chronic Closed-Angle Glaucoma

Categories: Eye diseases

Aliases & Classifications for Chronic Closed-Angle Glaucoma

MalaCards integrated aliases for Chronic Closed-Angle Glaucoma:

Name: Chronic Closed-Angle Glaucoma 12 15
Anatomical Narrow Angle Glaucoma 12 72
Chronic Angle-Closure Glaucoma 12 55
Secondary Angle-Closure Glaucoma - Synechial 72
Chronic Narrow Angle Glaucoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:14445
ICD9CM 35 365.23
SNOMED-CT 68 15417005 33647009
ICD10 33 H40.22
UMLS 72 C0154947 C1272657

Summaries for Chronic Closed-Angle Glaucoma

MalaCards based summary : Chronic Closed-Angle Glaucoma, also known as anatomical narrow angle glaucoma, is related to optic nerve disease and cataract. An important gene associated with Chronic Closed-Angle Glaucoma is TGFB2 (Transforming Growth Factor Beta 2), and among its related pathways/superpathways are NF-KappaB Family Pathway and Nanog in Mammalian ESC Pluripotency. The drugs Pilocarpine and Travoprost have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and endothelial, and related phenotypes are cardiovascular system and growth/size/body region

Related Diseases for Chronic Closed-Angle Glaucoma

Diseases in the Acute Closed-Angle Glaucoma family:

Chronic Closed-Angle Glaucoma

Diseases related to Chronic Closed-Angle Glaucoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)
# Related Disease Score Top Affiliating Genes
1 optic nerve disease 30.3 MYOC EDN1 AQP4
2 cataract 10.7
3 acute closed-angle glaucoma 10.6
4 primary angle-closure glaucoma 10.5
5 open-angle glaucoma 10.5
6 intraocular pressure quantitative trait locus 10.4
7 glaucoma, primary open angle 10.4
8 multilocular clear cell renal cell carcinoma 10.4 TGFB3 TGFB2
9 myopia 10.3
10 weill-marchesani syndrome 10.3
11 hydrarthrosis 10.2 AQP7 AQP3 AQP1
12 chronic gonococcal salpingitis 10.2 TNFRSF1A CTSA
13 retinal detachment 10.1
14 retinitis pigmentosa 10.1
15 yemenite deaf-blind hypopigmentation syndrome 10.1
16 microvascular complications of diabetes 5 10.1
17 weill-marchesani syndrome 4 10.1
18 microcephaly, epilepsy, and diabetes syndrome 10.1
19 spastic paraplegia, intellectual disability, nystagmus, and obesity 10.1
20 exudative vitreoretinopathy 10.1
21 brachydactyly 10.1
22 neuroretinitis 10.1
23 corneal edema 10.1
24 lens subluxation 10.1
25 uveitis 10.1
26 retinal vein occlusion 10.1
27 central retinal vein occlusion 10.1
28 phimosis 10.1
29 retinitis 10.1
30 macular retinal edema 10.1
31 eye disease 10.1
32 ocular hypertension 10.1
33 scotoma 10.1
34 refractive error 10.1
35 anterior uveitis 10.1
36 obsolete: brachydactyly of fingers 10.1
37 vitreoretinopathy 10.1
38 diabetes insipidus, nephrogenic, autosomal 10.0 AQP4 AQP3 AQP1
39 loeys-dietz syndrome 4 10.0 TGFB3 TGFB2
40 diffuse pulmonary fibrosis 10.0 TIMP1 BMP7 AQP5
41 central pontine myelinolysis 10.0 AQP4 AQP1
42 oligohydramnios 9.8 EDN1 AQP3 AQP1
43 meniere disease 9.7 AQP7 AQP5 AQP4 AQP3 AQP1
44 demyelinating disease 9.7 TNFRSF1A CXCL10 AQP4
45 microvascular complications of diabetes 1 9.6 TIMP1 TGFB2 EDN1
46 tendinosis 9.5 TNFRSF1A TIMP1 TGFB2 CXCL10

Comorbidity relations with Chronic Closed-Angle Glaucoma via Phenotypic Disease Network (PDN):


Glaucoma, Primary Open Angle Hypertension, Essential

Graphical network of the top 20 diseases related to Chronic Closed-Angle Glaucoma:



Diseases related to Chronic Closed-Angle Glaucoma

Symptoms & Phenotypes for Chronic Closed-Angle Glaucoma

MGI Mouse Phenotypes related to Chronic Closed-Angle Glaucoma:

46 (show all 18)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.42 AQP1 AQP3 AQP4 BMP7 CTSA CXCL10
2 growth/size/body region MP:0005378 10.41 AQP1 AQP3 AQP4 AQP5 AQP7 BMP7
3 homeostasis/metabolism MP:0005376 10.34 AQP1 AQP3 AQP4 AQP5 AQP7 CTSA
4 mortality/aging MP:0010768 10.31 AQP1 AQP3 AQP4 AQP5 BMP7 CTSA
5 endocrine/exocrine gland MP:0005379 10.29 AQP1 AQP4 AQP5 AQP7 BMP7 EDN1
6 hematopoietic system MP:0005397 10.25 AQP1 AQP4 BMP7 CTSA CXCL10 GJA1
7 craniofacial MP:0005382 10.22 AQP3 BMP7 CTSA EDN1 GJA1 SFRP1
8 immune system MP:0005387 10.22 AQP3 AQP4 BMP7 CTSA CXCL10 GJA1
9 digestive/alimentary MP:0005381 10.16 AQP3 AQP4 AQP5 BMP7 EDN1 TGFB2
10 nervous system MP:0003631 10.14 AQP1 AQP4 BMP7 CXCL10 EDN1 GJA1
11 hearing/vestibular/ear MP:0005377 10.13 AQP1 AQP3 AQP4 AQP5 BMP7 EDN1
12 limbs/digits/tail MP:0005371 10 BMP7 GJA1 SFRP1 TGFB2 TGFB3 TIMP1
13 renal/urinary system MP:0005367 9.97 AQP1 AQP3 AQP4 AQP7 BMP7 CTSA
14 no phenotypic analysis MP:0003012 9.91 AQP4 AQP5 GJA1 KIDINS220 MYOC SFRP1
15 reproductive system MP:0005389 9.91 AQP1 AQP7 BMP7 CTSA GJA1 SFRP1
16 respiratory system MP:0005388 9.9 AQP1 AQP3 AQP4 AQP5 BMP7 CTSA
17 skeleton MP:0005390 9.65 AQP1 AQP3 BMP7 EDN1 GJA1 SFRP1
18 vision/eye MP:0005391 9.36 AQP1 AQP3 AQP4 AQP5 BMP7 GJA1

Drugs & Therapeutics for Chronic Closed-Angle Glaucoma

DrugBank drugs 16 :

# Drug Name Indication DrugBank ID
1 Echothiophate For use in the treatment of subacute or chronic angle-closure glaucoma after iridectomy or where surgery is refused or contraindicated. DB01057

Drugs for Chronic Closed-Angle Glaucoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pilocarpine Approved, Investigational Phase 4 92-13-7, 54-71-7 5910
2
Travoprost Approved Phase 4 157283-68-6 5282226
3
Latanoprost Approved, Investigational Phase 4 130209-82-4 5282380 5311221
4
Timolol Approved Phase 4 26839-75-8 33624 5478
5
Brinzolamide Approved Phase 4 138890-62-7 68844
6
Maleic acid Experimental, Investigational Phase 4 110-17-8, 110-16-7 444972
7 Cholinergic Agents Phase 4
8 Peripheral Nervous System Agents Phase 4
9 Muscarinic Agonists Phase 4
10 Autonomic Agents Phase 4
11 Antihypertensive Agents Phase 4
12 Ophthalmic Solutions Phase 4
13 Pharmaceutical Solutions Phase 4
14 Neurotransmitter Agents Phase 4
15 Adrenergic alpha-2 Receptor Agonists Phase 4
16 Adrenergic alpha-Agonists Phase 4
17 Adrenergic Agonists Phase 4
18 Adrenergic beta-Antagonists Phase 4
19 Adrenergic Antagonists Phase 4
20 Adrenergic Agents Phase 4
21 Anti-Arrhythmia Agents Phase 4
22 Brimonidine Tartrate Phase 4 70359-46-5
23 Brimonidine Tartrate, Timolol Maleate Drug Combination Phase 4
24 Carbonic Anhydrase Inhibitors Phase 4
25
Bimatoprost Approved, Investigational 155206-00-1 5311027

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 A Twelve-Week, Double Masked, Parallel Group, Primary-Therapy Pilot Study of the Safety and Efficacy of Travoprost 0.004% Compared to Pilocarpine 1% in Patients With Chronic Angle-Closure Glaucoma Completed NCT00762645 Phase 4 Travoprost 0.004% (Travatan);Pilocarpine 1%
2 An 8 Week, Single Masked, Parallel-Group, Exploratory Study Comparing Ocular Surface Signs and Symptoms in Monotherapy Ocular Hypertension or Glaucoma Patients Randomized to Either Xalatan® or Travatan Z® Completed NCT00799682 Phase 4 Xalatan;Travatan Z
3 Study of Brimonidine and Timolol Ophthalmic Solution With Latanoprost Compared With Latanoprost in Glaucoma Patients Terminated NCT01151904 Phase 4 brimonidine 0.2%/timolol 0.5% fixed combination ophthalmic solution;latanoprost
4 A Double-Masked, Parallel-Group, Efficacy and Safety Study of Brinzolamide 1.0% (AZOPT) as Adjunctive Therapy to Travoprost 0.004% (TRAVATAN) in Patients With Chronic Angle-Closure Glaucoma Terminated NCT00758342 Phase 4 Travoprost 0.004% + Brinzolamide 1.0%;Travoprost 0.004% + Tears Natural
5 A Safety and Efficacy Study of Travoprost 0.004% Compared to Latanoprost 0.005% in Patients With Chronic Angle-Closure Glaucoma. Completed NCT00051181 Phase 3 Travoprost (0.004%);Latanoprost (0.005%)
6 A Prospective Study to Assess the Hypotensive Efficacy of Rho-Kinase Inhibitor AR-12286 Ophthalmic Solution 0.5% and 0.7% in Patients With Chronic Angle-closure Glaucoma Unknown status NCT02152774 Phase 2 Rho-Kinase Inhibitor
7 Prevalence of Chronic Angle Closure in Caucasian Hyperopic Subjects Unknown status NCT00823706
8 Comparison of Bimatoprost and Lataprost in Patients With Chronic Angle-Closure Glaucoma: A Randomized Cross-Over Study Unknown status NCT00567788 Latanoprost-Bimatoprost;Bimatoporost-Latanoprost
9 Biometric Indicators of Eyes With Occult Lens Subluxation Completed NCT03752710
10 Angle Closure: Laser Iridotomy Versus Phacoemulsification Study (ACLIPS)- A Study of Acute Primary Angle Closure Glaucoma Comparing Two Treatment Modalities: Laser Peripheral vs Phacoemulsification With Posterior Intraocular Lens Implant Completed NCT00350428
11 Comparison Study of Glaucoma Eye Care Follow-Up Adherence in a High Risk Population Completed NCT02347670
12 Sequential Laser Iridotomy Using Argon and Q-Switched 532 nm Frequency Doubled Neodymium Yag Laser: A Pilot Study Completed NCT00452998

Search NIH Clinical Center for Chronic Closed-Angle Glaucoma

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Echothiophate

Genetic Tests for Chronic Closed-Angle Glaucoma

Anatomical Context for Chronic Closed-Angle Glaucoma

MalaCards organs/tissues related to Chronic Closed-Angle Glaucoma:

41
Eye, Testes, Endothelial

Publications for Chronic Closed-Angle Glaucoma

Articles related to Chronic Closed-Angle Glaucoma:

(show top 50) (show all 320)
# Title Authors PMID Year
1
A phase III study of subconjunctival human anti-transforming growth factor beta(2) monoclonal antibody (CAT-152) to prevent scarring after first-time trabeculectomy. 9 38
17908591 2007
2
Aqueous humor levels of TGFβ2 and SFRP1 in different types of glaucoma. 38
31382918 2019
3
Differential Efficacy of Combined Phacoemulsification and Endocyclophotocoagulation in Open-angle Glaucoma Versus Angle-closure Glaucoma. 38
30839415 2019
4
Anterior Segment Features in Nanophthalmos With Secondary Chronic Angle Closure Glaucoma: An Ultrasound Biomicroscopy Study. 38
31112609 2019
5
Early results of micropulse transscleral cyclophotocoagulation for the treatment of glaucoma. 38
30938190 2019
6
Surgical outcomes of phacoemulsification/goniosynechialysis with and without endocyclophotocoagulation in patients with chronic angle closure glaucoma. 38
30777954 2019
7
Primary Outcomes of Patients with Chronic Angle-Closure Glaucoma Treated with Combined Phacoemulsification, Viscogoniosynechialysis, and Endocyclophotocoagulation. 38
31312531 2019
8
Post-miosis changes in the anterior chamber structures in primary and lens-induced secondary chronic angle-closure glaucoma. 38
31024825 2019
9
Indicating and predicting role of the horizontal C/D ratio in preclinical diabetic retinopathy associated with chronic angle-closure glaucoma. 38
30809483 2019
10
Cypass Supraciliary Stent in Eye With Chronic Angle Closure and Postvitrectomy With Silicone Oil. 38
29979341 2018
11
Profile and management outcomes of glaucoma cases at Qassim University Hospital. 38
30202404 2018
12
Angle-closure Glaucoma in a Myopic Patient Precipitated by Sexual Excitation: A Case Report. 38
31354207 2018
13
Factors Associated with Outcomes of Combined Phacoemulsification and Ahmed Glaucoma Valve Implantation. 38
29770636 2018
14
Retinal pigment epithelium changes in Kartagener syndrome. 38
29511746 2018
15
Long-term outcomes after acute primary angle closure of Caucasian chronic angle closure glaucoma patients. 38
28722309 2018
16
Macular Choroidal Small-Vessel Layer, Sattler's Layer and Haller's Layer Thicknesses: The Beijing Eye Study. 38
29535365 2018
17
Refractive outcomes of phacoemulsification cataract surgery in glaucoma patients. 38
29605284 2018
18
Visual Subfield Progression in Glaucoma Subtypes. 38
29750123 2018
19
Longitudinal Change in Peripheral Anterior Chamber Depth of Eyes with Angle Closure after Laser Iridotomy. 38
30671261 2018
20
Optic Nerve Head Characteristics in Chronic Angle Closure Glaucoma Detected by Swept-Source OCT. 38
28922031 2017
21
Ocular pulse amplitude in different types of glaucoma using dynamic contour tonometry: Diagnosis and follow-up of glaucoma. 38
29104631 2017
22
Long-term scanning laser ophthalmoscopy and perimetry in different severities of primary open and chronic angle closure glaucoma eyes. 38
29044061 2017
23
Acute hypotony maculopathy following the initiation of a topical aqueous suppressant in a patient with a history of panuveitis without prior filtering surgery. 38
29260088 2017
24
Intraoperative Optical Coherence Tomography-Assisted Descemet Stripping Automated Endothelial Keratoplasty for Anterior Chamber Fibrous Ingrowth. 38
28399038 2017
25
RETINAL AND CHOROIDAL VASCULAR OCCLUSION FOLLOWING AQUEOUS MISDIRECTION SYNDROME IN A PATIENT WITH SICKLE CELL TRAIT. 38
28489705 2017
26
High intensity focused ultrasound as first line treatment in patients with chronic angle closure glaucoma at risk for malignant glaucoma. 38
28342558 2017
27
Analyzing cytokines as biomarkers to evaluate severity of glaucoma. 38
28730084 2017
28
Peripapillary retinal splitting visualized on OCT in glaucoma and glaucoma suspect patients. 38
28832670 2017
29
Bilateral Same-day Laser Peripheral Iridotomy in the Philadelphia Glaucoma Detection and Treatment Project. 38
26950579 2016
30
Pupillary block due to reverse implantation of a sulcus intraocular lens. 38
28184333 2016
31
Intraoperative floppy-iris syndrome associated with use of antipsychotic drugs. 38
27521670 2016
32
Risk Factors of Disease Progression After Cataract Surgery in Chronic Angle-closure Glaucoma Patients. 38
26550967 2016
33
Efficacy and Safety of Trabectome Surgery in Chinese Open-Angle Glaucoma. 38
27082559 2016
34
Endoscopic Cyclophotocoagulation and Pars Plana Ablation (ECP-plus) to Treat Refractory Glaucoma. 38
26020690 2016
35
The Frequency of Optical Coherence Tomography Testing in Glaucoma at a Single Academic Medical Center. 38
26372155 2016
36
The effect of adjustable suture (Khaw) trabeculectomy on intraocular pressure: a retrospective case series. 38
26002838 2016
37
Case report: imaging and treatment of ophthalmic manifestations in oculodentodigital dysplasia. 38
26743931 2016
38
Comparison of phacotrabeculectomy and sequential surgery in the treatment of chronic angle-closure glaucoma coexisted with cataract. 38
27275422 2016
39
The safety and efficacy of modified minimally invasive trabeculectomy for the treatment of primary chronic angle-closure glaucoma. 38
27215005 2015
40
Rapid anterior capsular phimosis after cataract surgery in a patient with chronic angle closure glaucoma. 38
29018698 2015
41
Transscleral cyclophotocoagulation in refractory acute and chronic angle closure glaucoma. 38
26424819 2015
42
Effect of Goniosynechialysis During Phacoemulsification on IOP in Patients With Medically Well-controlled Chronic Angle-Closure Glaucoma. 38
25387342 2015
43
Diode laser cyclophotocoagulation for nanophthalmic chronic angle closure glaucoma. 38
23807357 2015
44
Prevalence of comorbid retinal disease in patients with glaucoma at an academic medical center. 38
26203217 2015
45
Diffusion tensor imaging of optic nerve and optic radiation in primary chronic angle-closure glaucoma using 3T magnetic resonance imaging. 38
26558212 2015
46
T-helper1/T-helper2 cytokine imbalance in the iris of patients with glaucoma. 38
25811482 2015
47
Meta-analysis of randomized controlled trials comparing latanoprost with other glaucoma medications in chronic angle-closure glaucoma. 38
25044139 2015
48
Delayed diagnosis of subacute angle closure glaucoma in patients presenting with headaches. 38
24677021 2014
49
Reduced intraocular pressure after cataract surgery in patients with narrow angles and chronic angle-closure glaucoma. 38
25134991 2014
50
Effectivity of Nd Yag PI in treatment of acute primary angle closure glaucoma. 38
25799811 2014

Variations for Chronic Closed-Angle Glaucoma

Expression for Chronic Closed-Angle Glaucoma

Search GEO for disease gene expression data for Chronic Closed-Angle Glaucoma.

Pathways for Chronic Closed-Angle Glaucoma

Pathways related to Chronic Closed-Angle Glaucoma according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.42 TNFRSF1A TIMP1 TGFB3 TGFB2 BMP7
2
Show member pathways
12.37 TNFRSF1A TIMP1 TGFB3 TGFB2 BMP7 AQP7
3 11.93 TGFB3 TGFB2 SFRP1 BMP7
4 11.78 TNFRSF1A EDN1 CXCL10
5
Show member pathways
11.77 AQP7 AQP5 AQP4 AQP3 AQP1
6 11.71 TGFB3 TGFB2 EDN1
7
Show member pathways
11.67 TNFRSF1A TIMP1 TGFB3 TGFB2 BMP7
8 11.64 TIMP1 TGFB3 TGFB2
9 11.64 TGFB3 TGFB2 BMP7
10 11.54 TIMP1 TGFB3 TGFB2 BMP7
11 11.54 GJA1 CXCL10 AQP4 AQP1
12
Show member pathways
11.52 TGFB3 TGFB2 BMP7
13 11.48 TGFB3 TGFB2 CXCL10
14 11.41 TIMP1 EDN1 BMP7
15 11.19 TNFRSF1A TIMP1 CXCL10
16 10.83 TIMP1 TGFB3 TGFB2 CXCL10 BMP7

GO Terms for Chronic Closed-Angle Glaucoma

Cellular components related to Chronic Closed-Angle Glaucoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.61 TNFRSF1A TIMP1 TGFB3 TGFB2 SFRP1 MYOC
2 collagen-containing extracellular matrix GO:0062023 9.56 TGFB3 TGFB2 SFRP1 BMP7
3 extracellular region GO:0005576 9.36 TNFRSF1A TIMP1 TGFB3 TGFB2 SFRP1 RNASE2
4 platelet alpha granule lumen GO:0031093 9.33 TIMP1 TGFB3 TGFB2

Biological processes related to Chronic Closed-Angle Glaucoma according to GeneCards Suite gene sharing:

(show all 38)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.99 TIMP1 TGFB3 TGFB2 SFRP1 EDN1 CXCL10
2 response to drug GO:0042493 9.97 TGFB2 SFRP1 EDN1 AQP1
3 regulation of apoptotic process GO:0042981 9.96 TGFB3 TGFB2 PRELID1 BMP7
4 negative regulation of gene expression GO:0010629 9.95 TGFB2 SFRP1 GJA1 EDN1
5 in utero embryonic development GO:0001701 9.92 TGFB3 KIDINS220 GJA1 EDN1
6 platelet degranulation GO:0002576 9.85 TIMP1 TGFB3 TGFB2
7 negative regulation of cell growth GO:0030308 9.85 TGFB2 SFRP1 GJA1
8 osteoblast differentiation GO:0001649 9.84 SFRP1 MYOC GJA1
9 wound healing GO:0042060 9.84 TIMP1 TGFB3 TGFB2
10 neutrophil chemotaxis GO:0030593 9.82 TGFB2 EDN1 CXCL10
11 cellular response to mechanical stimulus GO:0071260 9.82 TNFRSF1A GJA1 AQP1
12 cell-cell signaling GO:0007267 9.81 GJA1 EDN1 CXCL10
13 cartilage development GO:0051216 9.81 TIMP1 EDN1 BMP7
14 cell development GO:0048468 9.77 TGFB3 TGFB2 BMP7
15 SMAD protein signal transduction GO:0060395 9.77 TGFB3 TGFB2 BMP7
16 response to peptide hormone GO:0043434 9.76 TIMP1 GJA1 BMP7
17 positive regulation of stress fiber assembly GO:0051496 9.75 TGFB3 SFRP1 MYOC
18 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.74 TGFB3 TGFB2 BMP7
19 positive regulation of epithelial to mesenchymal transition GO:0010718 9.72 TGFB3 TGFB2 BMP7
20 regulation of MAPK cascade GO:0043408 9.67 TGFB3 TGFB2 MYOC BMP7
21 secondary palate development GO:0062009 9.66 TGFB3 TGFB2
22 renal water homeostasis GO:0003091 9.65 AQP4 AQP3 AQP1
23 cellular response to hypoxia GO:0071456 9.65 SFRP1 EDN1 BMP7 AQP3 AQP1
24 multicellular organismal water homeostasis GO:0050891 9.63 AQP4 AQP1
25 regulation of branching involved in prostate gland morphogenesis GO:0060687 9.61 SFRP1 BMP7
26 pancreatic juice secretion GO:0030157 9.61 AQP5 AQP1
27 cell-cell junction organization GO:0045216 9.61 TGFB3 TGFB2 GJA1
28 response to vitamin D GO:0033280 9.58 CXCL10 BMP7 AQP3
29 negative regulation of macrophage cytokine production GO:0010936 9.56 TGFB3 TGFB2
30 carbon dioxide transport GO:0015670 9.54 AQP5 AQP1
31 salivary gland morphogenesis GO:0007435 9.5 TGFB3 TGFB2 BMP7
32 nitric oxide transport GO:0030185 9.49 EDN1 AQP1
33 uterine wall breakdown GO:0042704 9.46 TGFB3 TGFB2
34 odontogenesis GO:0042476 9.35 TGFB3 TGFB2 AQP5 AQP3 AQP1
35 glycerol transport GO:0015793 9.33 AQP7 AQP3 AQP1
36 water transport GO:0006833 9.02 AQP7 AQP5 AQP4 AQP3 AQP1
37 negative regulation of cell proliferation GO:0008285 10.02 TGFB3 TGFB2 SFRP1 GJA1 BMP7
38 transmembrane transport GO:0055085 10 GJA1 AQP7 AQP5 AQP4 AQP3 AQP1

Molecular functions related to Chronic Closed-Angle Glaucoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.71 TIMP1 TGFB3 TGFB2 BMP7
2 cytokine activity GO:0005125 9.63 TIMP1 TGFB3 TGFB2 EDN1 CXCL10 BMP7
3 transforming growth factor beta receptor binding GO:0005160 9.54 TGFB3 TGFB2 BMP7
4 type II transforming growth factor beta receptor binding GO:0005114 9.46 TGFB3 TGFB2
5 channel activity GO:0015267 9.35 AQP7 AQP5 AQP4 AQP3 AQP1
6 glycerol channel activity GO:0015254 9.32 AQP7 AQP3
7 type III transforming growth factor beta receptor binding GO:0034714 9.26 TGFB3 TGFB2
8 water transmembrane transporter activity GO:0005372 9.13 AQP1
9 water channel activity GO:0015250 9.02 AQP7 AQP5 AQP4 AQP3 AQP1

Sources for Chronic Closed-Angle Glaucoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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