Chronic Closed-Angle Glaucoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Sources

Aliases & Classifications for Chronic Closed-Angle Glaucoma

MalaCards integrated aliases for Chronic Closed-Angle Glaucoma:

Name: Chronic Closed-Angle Glaucoma ¹² ¹⁵

Anatomical Narrow Angle Glaucoma ¹² ⁷³

Chronic Angle-Closure Glaucoma ¹² ⁵⁵

Secondary Angle-Closure Glaucoma - Synechial ⁷³

Chronic Narrow Angle Glaucoma ¹²

Classifications:

MalaCards categories:
Anatomical: Eye diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:14445

ICD10 ³³ H40.22

ICD9CM ³⁵ 365.23

SNOMED-CT ⁶⁸ 15417005 33647009

UMLS ⁷³ C0154947 C1272657

Sources

Summaries for Chronic Closed-Angle Glaucoma

MalaCards based summary : Chronic Closed-Angle Glaucoma, also known as anatomical narrow angle glaucoma, is related to glaucoma, primary open angle and low tension glaucoma. An important gene associated with Chronic Closed-Angle Glaucoma is TGFB2 (Transforming Growth Factor Beta 2). The drugs Latanoprost and Pilocarpine have been mentioned in the context of this disorder. Affiliated tissues include eye and endothelial, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Sources

Related Diseases for Chronic Closed-Angle Glaucoma

Diseases in the Acute Closed-Angle Glaucoma family:

Chronic Closed-Angle Glaucoma

Diseases related to Chronic Closed-Angle Glaucoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 19)

#	Related Disease	Score	Top Affiliating Genes
1	glaucoma, primary open angle	30.1	OPTN PHEX TGFB2
2	low tension glaucoma	30.1	OPTN PHEX
3	open-angle glaucoma	30.1	OPTN TGFB2
4	acute closed-angle glaucoma	29.9	CTSA OPTN
5	cataract	10.3
6	weill-marchesani syndrome	10.2
7	retinal vein occlusion	10.1
8	exudative vitreoretinopathy	10.1
9	central retinal vein occlusion	10.1
10	phimosis	10.1
11	neovascular glaucoma	10.0	OPTN TGFB2
12	traumatic glaucoma	10.0	OPTN PHEX
13	phacogenic glaucoma	10.0	OPTN PHEX
14	iris disease	10.0	OPTN PHEX
15	lens disease	9.9	OPTN PHEX
16	uveal disease	9.9	OPTN PHEX
17	corneal disease	9.9	OPTN TGFB2
18	juvenile glaucoma	9.8	OPTN PHEX TGFB2
19	corneal endothelial dystrophy	9.8	CTSA OPTN

Comorbidity relations with Chronic Closed-Angle Glaucoma via Phenotypic Disease Network (PDN):

Glaucoma, Primary Open Angle

Hypertension, Essential

Graphical network of the top 20 diseases related to Chronic Closed-Angle Glaucoma:

Sources

Symptoms & Phenotypes for Chronic Closed-Angle Glaucoma

GenomeRNAi Phenotypes related to Chronic Closed-Angle Glaucoma according to GeneCards Suite gene sharing:

²⁶ (show all 18)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased shRNA abundance (Z-score > 2)	GR00366-A-107	9.62	TGFB2
2	Increased shRNA abundance (Z-score > 2)	GR00366-A-11	9.62	TGFB2
3	Increased shRNA abundance (Z-score > 2)	GR00366-A-115	9.62	TGFB2
4	Increased shRNA abundance (Z-score > 2)	GR00366-A-133	9.62	TGFB2
5	Increased shRNA abundance (Z-score > 2)	GR00366-A-138	9.62	TGFB2
6	Increased shRNA abundance (Z-score > 2)	GR00366-A-177	9.62	CTSA
7	Increased shRNA abundance (Z-score > 2)	GR00366-A-196	9.62	TGFB2
8	Increased shRNA abundance (Z-score > 2)	GR00366-A-199	9.62	CTSA
9	Increased shRNA abundance (Z-score > 2)	GR00366-A-21	9.62	CTSA
10	Increased shRNA abundance (Z-score > 2)	GR00366-A-215	9.62	CTSA TGFB2
11	Increased shRNA abundance (Z-score > 2)	GR00366-A-25	9.62	CTSA
12	Increased shRNA abundance (Z-score > 2)	GR00366-A-42	9.62	CTSA TGFB2
13	Increased shRNA abundance (Z-score > 2)	GR00366-A-50	9.62	CTSA TGFB2
14	Increased shRNA abundance (Z-score > 2)	GR00366-A-73	9.62	TGFB2
15	Increased shRNA abundance (Z-score > 2)	GR00366-A-81	9.62	CTSA
16	Increased shRNA abundance (Z-score > 2)	GR00366-A-93	9.62	CTSA
17	Increased shRNA abundance (Z-score > 2)	GR00366-A-96	9.62	CTSA
18	Decreased caspase 3/7 activity	GR00318-A	8.96	CTSA PHEX

MGI Mouse Phenotypes related to Chronic Closed-Angle Glaucoma:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	9.35	AQP7 CTSA OPTN PHEX TGFB2
2	renal/urinary system	MP:0005367	8.92	AQP7 CTSA PHEX TGFB2

Sources

Drugs & Therapeutics for Chronic Closed-Angle Glaucoma

Drugs for Chronic Closed-Angle Glaucoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Latanoprost

Approved, Investigational

Phase 4,Phase 3,Not Applicable

130209-82-4

5311221 5282380

Synonyms:

130209-82-4

AC1NSK8Q

Ambap130209-82-4

AR-202

Catioprost

CHEBI:6384

CHEMBL1051

CID5311221

CPD000466354

D00356

HMS2051H11

HMS2089J17

isopropyl (5Z,9alpha,11alpha,15R)-9,11,15-trihydroxy-17-phenyl-18,19,20-trinorprost-5-en-1-oate

Isopropyl (5Z,9alpha,11alpha,15R)-9,11,15-trihydroxy-17-phenyl-18,19,20-trinor-prost-5-en-1-oate

Isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((3R)-3-hydroxy-5-phenylpentyl)cyclopentyl)-5-heptenoate

Isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((3R)-3-hydroxy-5-phenylpentyl)cyclopentyl)-5-heptenoic acid

Jsp001835

L1167_SIGMA

latanoprost

Latanoprost

Latanoprost (JAN/USAN/INN)

latanoprost free acid

Latanoprostum

MLS000759468

MLS001424106

MolPort-003-942-862

Nova-21027

Pfizer brand OF latanoprost

PhXA 41

PhXA34

PhXA34 [as 15(R,S)-isomer]

PhXA41

PHXA41

PHXA-41

propan-2-yl (5Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl}hept-5-enoate

Propan-2-yl (5Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl}hept-5-enoate

Propan-2-yl (5Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl}hept-5-enoic acid

propan-2-yl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]hept-5-enoate

S1254_Selleck

SAM001246671

SMR000466354

TL8000716

XA41

XA-41

Xalatan

Xalatan (TN)

Xalatan Fixed Flow Device

ZINC12468792

2

Pilocarpine

Approved, Investigational

Phase 4

54-71-7, 92-13-7

5910

Synonyms:

(+)-Pilocarpine

(3S,4R)-3-ethyl-4-[(1-methyl-1H-imidazol-5-yl)methyl]dihydrofuran-2(3H)-one

(3S,4R)-3-ethyl-4-[(3-methylimidazol-4-yl)methyl]oxolan-2-one

(3S,4R)-3-ethyldihydro-4-((1-methyl-1H-imidazol-5-yl)methyl)-2(3H)-furanone

(3S,4R)-3-ethyldihydro-4-((1-Methyl-1H-imidazol-5-yl)methyl)-2(3H)-furanone

(3S,4R)-3-Ethyldihydro-4-((1-methyl-1H-imidazol-5-yl)methyl)-2(3H)-furanone

(3S-cis)-3-Ethyldihydro-4-((1-methyl-1H-imidazol-5-yl)methyl)-2(3H)-furanone

(3S-cis)-3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-2(3H)-furanone

(3S-cis)-3-ethyldihydro-4-[(1-Methyl-1H-imidazol-5-yl)methyl]-2(3H)-furanone

(3S-cis)-3-Ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-2(3H)-furanone

3-ethyl-4-((1-methyl-1H-imidazol-5-yl)methyl)dihydro-2(3H)-furanone

3-Ethyl-4-(3-methyl-3H-imidazol-4-ylmethyl)dihydrofuran-2-one

3-Ethyl-4-[(1-methyl-1H-imidazol-5-yl)methyl]dihydro-2(3H)-furanone

3-Ethyl-4-[(1-methyl-1H-imidazol-5-yl)methyl]dihydrofuran-2(3H)-one

3-ethyl-4-[(3-methylimidazol-4-yl)methyl]oxolan-2-one

54-71-7

91484-73-0

92-13-7

AC1L1J0W

AC1L1LEF

AC1Q6MOP

Adsorbocarpine

AI3-50523

Almocarpine

Amistura P

AR-1F3128

beta-Pilocarpine hydrochloride

BIDD:GT0217

BPBio1_000548

BRD-K85090592-008-05-2

BSPBio_000498

BSPBio_002191

C07474

CHEBI:39460

CHEBI:8207

CHEMBL550

CID4819

CID5910

D00525

DB01085

DivK1c_000358

EINECS 202-128-4

Epicar

HMS2089K17

HSDB 3163

Hydrochloride, pilocarpine

IDI1_000358

Imidazole-5-butyric acid, alpha-ethyl-beta-(hydroxymethyl)-1-methyl-, gamma-lactone

isopilocarpine

Isopilocarpine

Isopto carpine

Isoptocarpine

KBio1_000358

KBio2_001587

KBio2_004155

KBio2_006723

KBio3_001691

KBioGR_000956

KBioSS_001587

L001181

Lopac0_000950

Lopac0_000960

LS-187208

LS-7661

Minims Pilocarpine

Miocarpine

Mi-Pilo

MolPort-002-512-506

NCGC00023339-03

NCGC00023339-06

NCGC00023339-07

NCGC00023339-08

NCGC00023339-09

NCGC00023339-12

NCGC00023339-13

nchembio.78-comp9

NCI60_004403

NINDS_000358

Nitrate, pilocarpine

NSC5746

Ocu-Carpine

Ocusert

Ocusert P 20

Ocusert pilo

Ocusert pilo-20

Ocusert pilo-20 (TN)

Ocusert Pilo-40

P.V. Carpine Liquifilm

Pilagan

Pilocarpin

pilocarpine

Pilocarpine

Pilocarpine (JAN/USP)

Pilocarpine [USAN:BAN:JAN]

Pilocarpine chloride

Pilocarpine HCl

Pilocarpine HCL

Pilocarpine hydrochloride

Pilocarpine monohydrochloride

Pilocarpine mononitrate, (3S-cis)-isomer

Pilocarpine Mononitrate, (3S-cis)-Isomer

Pilocarpine muriate

Pilocarpine nitrate

Pilocarpine, monohydrochloride, (3S-cis)-isomer

Pilocarpine, Monohydrochloride, (3S-cis)-Isomer

Pilocarpol

Pilokarpin

Pilokarpin monohydrochloride

Pilokarpol

Piloptic-1

Piloptic-1/2

Piloptic-2

Piloptic-3

Piloptic-4

Piloptic-6

Pilostat

Prestwick0_000449

Prestwick1_000449

Prestwick2_000449

Prestwick3_000449

Salagen

SDCCGMLS-0003164.P005

SPBio_001287

SPBio_002437

Spectrum_001107

Spectrum2_001284

Spectrum3_000546

Spectrum4_000478

Spectrum5_001379

Spersacarpine

Spersacarpine hydrochloride

STOCK1N-18408

Syncarpine

Tocris-0694

UNII-01MI4Q9DI3

ZINC00075008

3

Travoprost

Approved

Phase 4,Phase 3

157283-68-6

5282226

Synonyms:

(((1R)-(1alpha(Z),2beta(1E,3R*),3alpha,5alpha))-7-(3,5-dihydroxy-2-(3-hydroxy-4-(3-trifluoromethyl)phenoxy)-1-butenyl)cyclopentyl)-5-heptenoic acid, 1-methylethyl ester

(+)-Fluprostenol isopropyl ester

(1R-(1alpha(Z),2beta(1E,3R*),3alpha,5alpha))-7-(3,5-Dihydroxy-2-(3-hydroxy-4-(3-(trifluoromethyl)phenoxy)-1-butenyl)cyclopentyl)-5-heptenoic acid, 1-methylethyl ester

(Z)-7-((1R,2R,3R,5S)-3,5-Dihydroxy-2-((1E,3R)-3-hydroxy-4-((alpha,alpha,alpha-trifluoro-m-isopropyl-tolyl)oxy)-1-butenyl)cyclopentyl)-5-heptenoate

157283-68-6

5-Heptenoic acid,7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((1E,3R)-3-hydroxy-4-(3-(trifluoromethyl)phenoxy)-1-butenyl)cyclopentyl)-,1-methylethyl ester,(5Z)

AC1NQZOS

AC-6103

AL6221

AL-6221

C26H35F3O6

CHEBI:746859

CHEMBL1200799

CID5282226

D01964

DB00287

Isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-{(1E,3R)-3-hydroxy-4-[(a,a,a-trifluoro-m-tolyl)oxy]-1-butenyl}cyclopentyl)-5-heptenoate

Isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-{(1E,3R)-3-hydroxy-4-[(a,a,a-trifluoro-m-tolyl)oxy]-1-butenyl}cyclopentyl)-5-heptenoic acid

isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-{(1E,3R)-3-hydroxy-4-[(alpha,alpha,alpha-trifluoro-m-tolyl)oxy]-1-butenyl}cyclopentyl)-5-heptenoate

Isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-{(1e,3R)-3-hydroxy-4-[(alpha,alpha,alpha-trifluoro-m-tolyl)oxy]-1-butenyl}cyclopentyl)-5-heptenoate

Isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-{(1E,3R)-3-hydroxy-4-[(alpha,alpha,alpha-trifluoro-m-tolyl)oxy]-1-butenyl}cyclopentyl)-5-heptenoate

Isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-{(1E,3R)-3-hydroxy-4-[(alpha,alpha,alpha-trifluoro-m-tolyl)oxy]-1-butenyl}cyclopentyl)-5-heptenoic acid

Isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-{(1E,3R)-3-hydroxy-4-[(α,α,α-trifluoro-m-tolyl)oxy]-1-butenyl}cyclopentyl)-5-heptenoate

Isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-{(1E,3R)-3-hydroxy-4-[(α,α,α-trifluoro-m-tolyl)oxy]-1-butenyl}cyclopentyl)-5-heptenoic acid

LS-173521

propan-2-yl (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-{(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-en-1-yl}cyclopentyl]hept-5-enoate

propan-2-yl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-enyl]cyclopentyl]hept-5-enoate

S1554_Selleck

Travatan

Travatan (TN)

Travatan Alcon

Travatan Z

Travatan, Travoprost

Travatanz

Travoprost

Travoprost (JAN/USAN/INN)

Travoprost [USAN]

Travoprostum

Z, Travatan

ZINC04474682

4

Brinzolamide

Approved

Phase 4

138890-62-7

68844

Synonyms:

(+)-4-ETHYLAMINO-3,4-DIHYDRO-2-(METHOXY)PROPYL-2H-THIENO[3,2-E]-1,2-THIAZINE-6-SULFONAMIDE-1,1-DIOXIDE

(4R)-4-(ethylamino)-2-(3-methoxypropyl)-1,1-dioxo-3,4-dihydrothieno[3,2-e]thiazine-6-sulfonamide

(4R)-4-(ethylamino)-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide

(R)-4-(ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-2H-thieno(3,2-e)-1,2-thiazine-6-sulfonamide

(R)-4-(Ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-2H-thieno(3,2-e)-1,2-thiazine-6-sulfonamide 1,1-dioxide

138890-62-7

2H-Thieno(3,2-e)-1,2-thiazine-6-sulfonamide,4-(ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-,1,1-dioxide,R

3znc

AB00513824

AC1L2AKA

AC1Q6UVB

AC-5277

AKOS005145708

AL 4862

AL04862

AL-4862

Alcon brand of brinzolamide

Alcon brand OF brinzolamide

Allphar brand of brinzolamide

Allphar brand OF brinzolamide

Azopt

Azopt (TN)

BIDD:GT0039

Birnzolamide

BPBio1_000539

BRD-K74913225-001-03-3

Brinzolamide

Brinzolamide (BRZ)

Brinzolamide (JAN/USP/INN)

Brinzolamide [USAN]

BSPBio_000489

BZ1

C07760

C111827

C12H21N3O5S3

CHEBI:3176

CHEMBL220491

CID68844

D00652

DB01194

FT-0082471

HMS1569I11

I09-0605

LS-173036

MLS002153787

MolPort-005-940-291

Prestwick0_000365

Prestwick1_000365

Prestwick2_000365

Prestwick3_000365

SMR001233169

SPBio_002410

UNII-9451Z89515

5

Timolol

Approved

Phase 4

26839-75-8

33624 5478

Synonyms:

(-)-3-Morpholino-4-(3-tert-butylamino-2-hydroxypropoxy)-1,2,5-thiadiazole

(2S)-1-((1,1-dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl)oxy)-2-propanol

(2S)-1-(tert-butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol

(2S)-1-[(1,1-dimethylethyl)amino]-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol

(S)-1-(1,1-(Dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl)oxy)-2-propanol

(S)-1-(tert-Butylamino)-3-((4-morpholino-1,2,5-thiadiazol-3-yl)oxy)propan-2-ol

(S)-1-(tert-butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol

(S)-timolol

131628-37-0

194288-09-0

26839-75-8

26921-17-5 (maleate (1:1) salt)

AB00513729

AC1L1PYN

AC1Q59QM

Apo-Timol

Apo-Timop

Aquanil

Betim

Betimol

Betimol (TN)

BIDD:GT0073

Blocadren

BPBio1_001008

BRD-K08806317-050-03-6

BSPBio_000916

C07141

C13H24N4O3S

CAS-26921-17-5

CHEBI:9599

CHEMBL499

CID33624

CPD001456519

D08600

DB00373

DB08625

EINECS 248-032-6

HMS2089I11

HSDB 6533

Istalol

L-714,465

Lopac0_001189

Lopac-T-6394

LS-122231

MK-950

NCGC00016038-01

NCGC00016038-02

NCGC00016798-01

NCGC00016798-07

NCGC00022033-02

NCGC00022033-04

NCGC00022033-05

Novo-Timol

Nu-Timolol

Oprea1_640981

Optimol

Phoxal-timolol

Prestwick0_000948

Prestwick1_000948

Prestwick2_000948

Prestwick3_000948

Proflax

S-(-)-3-(3-tert-Butylamino-2-hydroxypropoxy)-4-morpholino-1,2,5-thiadiazole

S(-)-Timolol maleate

SAM002564238

SPBio_003075

ST072193

Temserin

Tenopt

TIM

Timacar

Timacor

Tim-AK

timolol

Timolol

Timolol (INN)

Timolol (TN)

Timolol [USAN]

Timolol anhydrous

Timolol GFS

Timolol maleate

Timolol Maleate, (1:1) Salt

Timololo

Timololum

Timololum [INN-Latin]

Timopic

Timoptic

Timoptic in Ocudose

Timoptic OcuDose

Timoptic-XE

Timoptol

Tocris-0649

UNII-817W3C6175

6

Maleic acid

Experimental

Phase 4

110-16-7

444266

Synonyms:

(2E)-2-Butenedioate

(2E)-2-Butenedioic acid

(2E)-But-2-enedioate

(2E)-But-2-enedioic acid

(e)-2-Butenedioate

(e)-2-Butenedioic acid

2-(e)-Butenedioate

2-(e)-Butenedioic acid

Allomaleate

Allomaleic acid

Ammonium fumarate

Boletate

Boletic acid

e297

FC 33

Fumarate

Fumarsaeure

Furamag

Lichenate

Lichenic acid

Magnesium fumarate

Sodium fumarate

trans-1,2-Ethylenedicarboxylate

trans-1,2-Ethylenedicarboxylic acid

trans-2-Butenedioate

trans-2-Butenedioic acid

trans-But-2-enedioate

trans-But-2-enedioic acid

trans-Butenedioate

trans-Butenedioic acid

7

Antihypertensive Agents

Phase 4,Phase 3,Phase 2,Not Applicable

8

Pharmaceutical Solutions

Phase 4,Phase 2

9

Ophthalmic Solutions

Phase 4,Phase 2

10

Cholinergic Agents

Phase 4

11

Autonomic Agents

Phase 4

12

Neurotransmitter Agents

Phase 4

13

Muscarinic Agonists

Phase 4

14

Peripheral Nervous System Agents

Phase 4

15

Carbonic Anhydrase Inhibitors

Phase 4

16

Adrenergic alpha-Agonists

Phase 4

17

Adrenergic beta-Antagonists

Phase 4

18

Adrenergic alpha-2 Receptor Agonists

Phase 4

19

Anti-Arrhythmia Agents

Phase 4

20

Adrenergic Agonists

Phase 4

21

Brimonidine Tartrate

Phase 4

70359-46-5

22

Brimonidine Tartrate, Timolol Maleate Drug Combination

Phase 4

23

Adrenergic Agents

Phase 4

24

Adrenergic Antagonists

Phase 4

25

Bimatoprost

Approved, Investigational

Not Applicable

155206-00-1

5311027

Synonyms:

(5Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-5-phenylpent-1-en-1-yl]cyclopentyl}-N-ethylhept-5-enamide

(Z)-7-((1R,2R,3R,5S)-3,5-Dihydroxy-2-((1e,3S)-3-hydroxy-5-phenyl-1-pentenyl)cyclopentyl)-N-ethyl-5-heptenamide

(Z)-7-((1R,2R,3R,5S)-3,5-Dihydroxy-2-((1E,3S)-3-hydroxy-5-phenyl-1-pentenyl)cyclopentyl)-N-ethyl-5-heptenamide

(Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-hydroxy-5-phenylpent-1-enyl]cyclopentyl]-N-ethylhept-5-enamide

155206-00-1

15M

267244-98-4

5-Heptenamide,7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((1E,3S)-3-hydroxy-5-phenyl-1-pentenyl)cyclopentyl)-N-ehtyl-,(5Z)

AC1NSJUW

AGN 192024

AGN-192024

Bimataprost [USAN:INN:BAN]

bimatoprost

Bimatoprost

Bimatoprost (JAN/USAN/INN)

Bimatoprost [USAN:INN:BAN]

bimatoprostum

Bimatoprostum

CHEBI:39562

CHEBI:51230

CHEMBL1200963

CID5311027

D02724

DB00905

DB06863

I06-1275

I06-1277

Latisse

LS-181817

Lumigan

Lumigan (TN)

NCGC00181745-01

UNII-QXS94885MZ

ZINC04474405

Interventional clinical trials:

(show all 11)

#	Name	Status	NCT ID	Phase	Drugs
1	Travoprost 0.004% Versus Pilocarpine 1% in Patients With Chronic Angle Closure Glaucoma (CACG)	Completed	NCT00762645	Phase 4	Travoprost 0.004% (Travatan);Pilocarpine 1%
2	Exploratory Study Comparing Signs and Symptoms in Patients With Ocular Hypertension or Glaucoma Using Xalatan R® or Travatan Z®	Completed	NCT00799682	Phase 4	Xalatan;Travatan Z
3	Azopt (Brinzolamide 1.0%) Plus Travatan (Travoprost 0.004%) in Treating Patients With Chronic Angle-Closure Glaucoma (CACG)	Terminated	NCT00758342	Phase 4	Travoprost 0.004% + Brinzolamide 1.0%;Travoprost 0.004% + Tears Natural
4	Study of Brimonidine and Timolol Ophthalmic Solution With Latanoprost Compared With Latanoprost in Glaucoma Patients	Terminated	NCT01151904	Phase 4	brimonidine 0.2%/timolol 0.5% fixed combination ophthalmic solution;latanoprost
5	A Safety and Efficacy Study of Travoprost 0.004% Compared to Latanoprost 0.005% in Patients With Chronic Angle-Closure Glaucoma	Completed	NCT00051181	Phase 3	Travoprost (0.004%);Latanoprost (0.005%)
6	A Study to Assess the Effect of Rho-Kinase Inhibitor AR-12286 Ophthalmic Solution 0.5% and 0.7% in Patients With Chronic Angle-closure Glaucoma	Unknown status	NCT02152774	Phase 2	Rho-Kinase Inhibitor
7	Comparison of Bimatoprost and Latanoprost in Patients With Chronic Angle-Closure Glaucoma: A Randomized Cross-Over Study	Unknown status	NCT00567788	Not Applicable	Latanoprost-Bimatoprost;Bimatoporost-Latanoprost
8	Prevalence of Angle Closure in Caucasian Hyperopes	Unknown status	NCT00823706
9	Biometry of Occult Lens Subluxation Misdiagnosed as Primary Acute Angle Closed Glaucoma	Completed	NCT03752710
10	Sequential Laser Iridotomy Using Argon and Q-Switched 532 nm Frequency Doubled Neodymium Yag Laser: A Pilot Study	Completed	NCT00452998	Not Applicable
11	Advanced Glaucoma Progression Study	Active, not recruiting	NCT01742819

Search NIH Clinical Center for Chronic Closed-Angle Glaucoma

Sources

Genetic Tests for Chronic Closed-Angle Glaucoma

Sources

Anatomical Context for Chronic Closed-Angle Glaucoma

MalaCards organs/tissues related to Chronic Closed-Angle Glaucoma:

⁴¹

Eye, Endothelial

Sources

Publications for Chronic Closed-Angle Glaucoma

Articles related to Chronic Closed-Angle Glaucoma:

(show all 14)

#	Title	Authors	Year
1	Rapid anterior capsular phimosis after cataract surgery in a patient with chronic angle closure glaucoma. ( 29018698 )	Chang PY...Chang SW	2015
2	Interocular Asymmetry of the Visual Field Defects in Newly Diagnosed Normal-tension Glaucoma, Primary Open-angle Glaucoma, and Chronic Angle-closure Glaucoma. ( 23632403 )	Huang P....Zhang C.	2013
3	Phacoemulsification versus trabeculectomy in medically uncontrolled chronic angle-closure glaucoma without cataract. ( 23823520 )	Sangtam T.	2013
4	Diode Laser Cyclophotocoagulation for Nanophthalmic Chronic Angle Closure Glaucoma. ( 23807357 )		2013
5	Patterns of damage in chronic angle-closure glaucoma compared to primary open-angle glaucoma. ( 21470591 )	Nouri-Mahdavi K....Caprioli J.	2011
6	Weill Marchesani syndrome with chronic angle closure glaucoma in Ethiopia: a case report. ( 19743786 )		2009
7	Optic nerve head morphologic characteristics in chronic angle-closure glaucoma and normal-tension glaucoma. ( 19680054 )	Zhao L...Wang X	2009
8	Phacoemulsification versus combined phacotrabeculectomy in medically uncontrolled chronic angle closure glaucoma with cataracts. ( 19243831 )	Tham CC...Lai JS	2009
9	Chronic angle-closure glaucoma secondary to a suprachoroidal effusion induced by central retinal vein occlusion. ( 17552395 )	Papamatheakis D.G....Harasymowycz P.J.	2007
10	Surgical treatment of advanced chronic angle closure glaucoma in Weill-Marchesani syndrome. ( 15478742 )	Harasymowycz P...Wilson R	2004
11	Combined phacoemulsification and goniosynechialysis for uncontrolled chronic angle-closure glaucoma after acute angle-closure glaucoma. ( 10201585 )	Teekhasaenee C...Ritch R	1999
12	Familial exudative vitreoretinopathy associated with nonneovascular chronic angle-closure glaucoma. ( 9075081 )		1997
13	Filtering iridocycloretraction in chronic closed-angle glaucoma. ( 3976810 )		1985
14	Some observations on chronic closed-angle glaucoma. ( 13413136 )		1957

Sources

Genes for Chronic Closed-Angle Glaucoma

Genes related to Chronic Closed-Angle Glaucoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	TGFB2	Transforming Growth Factor Beta 2	Protein Coding	21.21	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵	17908591
2	OPTN	Optineurin	Protein Coding	15.46	DISEASES inferred ¹⁵
3	AQP7	Aquaporin 7	Protein Coding	14.96	DISEASES inferred ¹⁵
4	CTSA	Cathepsin A	Protein Coding	14.86	DISEASES inferred ¹⁵
5	PHEX	Phosphate Regulating Endopeptidase Homolog X-Linked	Protein Coding	14.82	DISEASES inferred ¹⁵

Sources

Variations for Chronic Closed-Angle Glaucoma

Sources

Expression for Chronic Closed-Angle Glaucoma

Search GEO for disease gene expression data for Chronic Closed-Angle Glaucoma.

Sources

Pathways for Chronic Closed-Angle Glaucoma

Sources

GO Terms for Chronic Closed-Angle Glaucoma

Biological processes related to Chronic Closed-Angle Glaucoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	skeletal system development	GO:0001501	8.96	PHEX TGFB2
2	cell death	GO:0008219	8.62	OPTN TGFB2

Sources

Sources for Chronic Closed-Angle Glaucoma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia