MCID: CHR054
MIFTS: 29

Chronic Closed-Angle Glaucoma

Categories: Eye diseases

Aliases & Classifications for Chronic Closed-Angle Glaucoma

MalaCards integrated aliases for Chronic Closed-Angle Glaucoma:

Name: Chronic Closed-Angle Glaucoma 12 15
Anatomical Narrow Angle Glaucoma 12 73
Chronic Angle-Closure Glaucoma 12 55
Secondary Angle-Closure Glaucoma - Synechial 73
Chronic Narrow Angle Glaucoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:14445
ICD10 33 H40.22
ICD9CM 35 365.23
SNOMED-CT 68 15417005 33647009

Summaries for Chronic Closed-Angle Glaucoma

MalaCards based summary : Chronic Closed-Angle Glaucoma, also known as anatomical narrow angle glaucoma, is related to glaucoma, primary open angle and low tension glaucoma. An important gene associated with Chronic Closed-Angle Glaucoma is TGFB2 (Transforming Growth Factor Beta 2). The drugs Latanoprost and Pilocarpine have been mentioned in the context of this disorder. Affiliated tissues include eye and endothelial, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Chronic Closed-Angle Glaucoma

Diseases in the Acute Closed-Angle Glaucoma family:

Chronic Closed-Angle Glaucoma

Diseases related to Chronic Closed-Angle Glaucoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 19)
# Related Disease Score Top Affiliating Genes
1 glaucoma, primary open angle 30.1 OPTN PHEX TGFB2
2 low tension glaucoma 30.1 OPTN PHEX
3 open-angle glaucoma 30.1 OPTN TGFB2
4 acute closed-angle glaucoma 29.9 CTSA OPTN
5 cataract 10.3
6 weill-marchesani syndrome 10.2
7 retinal vein occlusion 10.1
8 exudative vitreoretinopathy 10.1
9 central retinal vein occlusion 10.1
10 phimosis 10.1
11 neovascular glaucoma 10.0 OPTN TGFB2
12 traumatic glaucoma 10.0 OPTN PHEX
13 phacogenic glaucoma 10.0 OPTN PHEX
14 iris disease 10.0 OPTN PHEX
15 lens disease 9.9 OPTN PHEX
16 uveal disease 9.9 OPTN PHEX
17 corneal disease 9.9 OPTN TGFB2
18 juvenile glaucoma 9.8 OPTN PHEX TGFB2
19 corneal endothelial dystrophy 9.8 CTSA OPTN

Comorbidity relations with Chronic Closed-Angle Glaucoma via Phenotypic Disease Network (PDN):


Glaucoma, Primary Open Angle Hypertension, Essential

Graphical network of the top 20 diseases related to Chronic Closed-Angle Glaucoma:



Diseases related to Chronic Closed-Angle Glaucoma

Symptoms & Phenotypes for Chronic Closed-Angle Glaucoma

GenomeRNAi Phenotypes related to Chronic Closed-Angle Glaucoma according to GeneCards Suite gene sharing:

26 (show all 18)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-107 9.62 TGFB2
2 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.62 TGFB2
3 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.62 TGFB2
4 Increased shRNA abundance (Z-score > 2) GR00366-A-133 9.62 TGFB2
5 Increased shRNA abundance (Z-score > 2) GR00366-A-138 9.62 TGFB2
6 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.62 CTSA
7 Increased shRNA abundance (Z-score > 2) GR00366-A-196 9.62 TGFB2
8 Increased shRNA abundance (Z-score > 2) GR00366-A-199 9.62 CTSA
9 Increased shRNA abundance (Z-score > 2) GR00366-A-21 9.62 CTSA
10 Increased shRNA abundance (Z-score > 2) GR00366-A-215 9.62 CTSA TGFB2
11 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.62 CTSA
12 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.62 CTSA TGFB2
13 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.62 CTSA TGFB2
14 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.62 TGFB2
15 Increased shRNA abundance (Z-score > 2) GR00366-A-81 9.62 CTSA
16 Increased shRNA abundance (Z-score > 2) GR00366-A-93 9.62 CTSA
17 Increased shRNA abundance (Z-score > 2) GR00366-A-96 9.62 CTSA
18 Decreased caspase 3/7 activity GR00318-A 8.96 CTSA PHEX

MGI Mouse Phenotypes related to Chronic Closed-Angle Glaucoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.35 AQP7 CTSA OPTN PHEX TGFB2
2 renal/urinary system MP:0005367 8.92 AQP7 CTSA PHEX TGFB2

Drugs & Therapeutics for Chronic Closed-Angle Glaucoma

Drugs for Chronic Closed-Angle Glaucoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Latanoprost Approved, Investigational Phase 4,Phase 3,Not Applicable 130209-82-4 5311221 5282380
2
Pilocarpine Approved, Investigational Phase 4 54-71-7, 92-13-7 5910
3
Travoprost Approved Phase 4,Phase 3 157283-68-6 5282226
4
Brinzolamide Approved Phase 4 138890-62-7 68844
5
Timolol Approved Phase 4 26839-75-8 33624 5478
6
Maleic acid Experimental Phase 4 110-16-7 444266
7 Antihypertensive Agents Phase 4,Phase 3,Phase 2,Not Applicable
8 Pharmaceutical Solutions Phase 4,Phase 2
9 Ophthalmic Solutions Phase 4,Phase 2
10 Cholinergic Agents Phase 4
11 Autonomic Agents Phase 4
12 Neurotransmitter Agents Phase 4
13 Muscarinic Agonists Phase 4
14 Peripheral Nervous System Agents Phase 4
15 Carbonic Anhydrase Inhibitors Phase 4
16 Adrenergic alpha-Agonists Phase 4
17 Adrenergic beta-Antagonists Phase 4
18 Adrenergic alpha-2 Receptor Agonists Phase 4
19 Anti-Arrhythmia Agents Phase 4
20 Adrenergic Agonists Phase 4
21 Brimonidine Tartrate Phase 4 70359-46-5
22 Brimonidine Tartrate, Timolol Maleate Drug Combination Phase 4
23 Adrenergic Agents Phase 4
24 Adrenergic Antagonists Phase 4
25
Bimatoprost Approved, Investigational Not Applicable 155206-00-1 5311027

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Travoprost 0.004% Versus Pilocarpine 1% in Patients With Chronic Angle Closure Glaucoma (CACG) Completed NCT00762645 Phase 4 Travoprost 0.004% (Travatan);Pilocarpine 1%
2 Exploratory Study Comparing Signs and Symptoms in Patients With Ocular Hypertension or Glaucoma Using Xalatan R® or Travatan Z® Completed NCT00799682 Phase 4 Xalatan;Travatan Z
3 Azopt (Brinzolamide 1.0%) Plus Travatan (Travoprost 0.004%) in Treating Patients With Chronic Angle-Closure Glaucoma (CACG) Terminated NCT00758342 Phase 4 Travoprost 0.004% + Brinzolamide 1.0%;Travoprost 0.004% + Tears Natural
4 Study of Brimonidine and Timolol Ophthalmic Solution With Latanoprost Compared With Latanoprost in Glaucoma Patients Terminated NCT01151904 Phase 4 brimonidine 0.2%/timolol 0.5% fixed combination ophthalmic solution;latanoprost
5 A Safety and Efficacy Study of Travoprost 0.004% Compared to Latanoprost 0.005% in Patients With Chronic Angle-Closure Glaucoma Completed NCT00051181 Phase 3 Travoprost (0.004%);Latanoprost (0.005%)
6 A Study to Assess the Effect of Rho-Kinase Inhibitor AR-12286 Ophthalmic Solution 0.5% and 0.7% in Patients With Chronic Angle-closure Glaucoma Unknown status NCT02152774 Phase 2 Rho-Kinase Inhibitor
7 Comparison of Bimatoprost and Latanoprost in Patients With Chronic Angle-Closure Glaucoma: A Randomized Cross-Over Study Unknown status NCT00567788 Not Applicable Latanoprost-Bimatoprost;Bimatoporost-Latanoprost
8 Prevalence of Angle Closure in Caucasian Hyperopes Unknown status NCT00823706
9 Biometry of Occult Lens Subluxation Misdiagnosed as Primary Acute Angle Closed Glaucoma Completed NCT03752710
10 Sequential Laser Iridotomy Using Argon and Q-Switched 532 nm Frequency Doubled Neodymium Yag Laser: A Pilot Study Completed NCT00452998 Not Applicable
11 Advanced Glaucoma Progression Study Active, not recruiting NCT01742819

Search NIH Clinical Center for Chronic Closed-Angle Glaucoma

Genetic Tests for Chronic Closed-Angle Glaucoma

Anatomical Context for Chronic Closed-Angle Glaucoma

MalaCards organs/tissues related to Chronic Closed-Angle Glaucoma:

41
Eye, Endothelial

Publications for Chronic Closed-Angle Glaucoma

Articles related to Chronic Closed-Angle Glaucoma:

(show all 14)
# Title Authors Year
1
Rapid anterior capsular phimosis after cataract surgery in a patient with chronic angle closure glaucoma. ( 29018698 )
2015
2
Interocular Asymmetry of the Visual Field Defects in Newly Diagnosed Normal-tension Glaucoma, Primary Open-angle Glaucoma, and Chronic Angle-closure Glaucoma. ( 23632403 )
2013
3
Phacoemulsification versus trabeculectomy in medically uncontrolled chronic angle-closure glaucoma without cataract. ( 23823520 )
2013
4
Diode Laser Cyclophotocoagulation for Nanophthalmic Chronic Angle Closure Glaucoma. ( 23807357 )
2013
5
Patterns of damage in chronic angle-closure glaucoma compared to primary open-angle glaucoma. ( 21470591 )
2011
6
Weill Marchesani syndrome with chronic angle closure glaucoma in Ethiopia: a case report. ( 19743786 )
2009
7
Optic nerve head morphologic characteristics in chronic angle-closure glaucoma and normal-tension glaucoma. ( 19680054 )
2009
8
Phacoemulsification versus combined phacotrabeculectomy in medically uncontrolled chronic angle closure glaucoma with cataracts. ( 19243831 )
2009
9
Chronic angle-closure glaucoma secondary to a suprachoroidal effusion induced by central retinal vein occlusion. ( 17552395 )
2007
10
Surgical treatment of advanced chronic angle closure glaucoma in Weill-Marchesani syndrome. ( 15478742 )
2004
11
Combined phacoemulsification and goniosynechialysis for uncontrolled chronic angle-closure glaucoma after acute angle-closure glaucoma. ( 10201585 )
1999
12
Familial exudative vitreoretinopathy associated with nonneovascular chronic angle-closure glaucoma. ( 9075081 )
1997
13
Filtering iridocycloretraction in chronic closed-angle glaucoma. ( 3976810 )
1985
14
Some observations on chronic closed-angle glaucoma. ( 13413136 )
1957

Variations for Chronic Closed-Angle Glaucoma

Expression for Chronic Closed-Angle Glaucoma

Search GEO for disease gene expression data for Chronic Closed-Angle Glaucoma.

Pathways for Chronic Closed-Angle Glaucoma

GO Terms for Chronic Closed-Angle Glaucoma

Biological processes related to Chronic Closed-Angle Glaucoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 skeletal system development GO:0001501 8.96 PHEX TGFB2
2 cell death GO:0008219 8.62 OPTN TGFB2

Sources for Chronic Closed-Angle Glaucoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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