MCID: CHR054
MIFTS: 33

Chronic Closed-Angle Glaucoma

Categories: Eye diseases, Genetic diseases, Neuronal diseases

Aliases & Classifications for Chronic Closed-Angle Glaucoma

MalaCards integrated aliases for Chronic Closed-Angle Glaucoma:

Name: Chronic Closed-Angle Glaucoma 12 15
Anatomical Narrow Angle Glaucoma 12 70
Chronic Angle-Closure Glaucoma 12 54
Secondary Angle-Closure Glaucoma - Synechial 70
Chronic Narrow Angle Glaucoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:14445
ICD9CM 34 365.23
SNOMED-CT 67 33647009
ICD10 32 H40.22
UMLS 70 C0154947 C1272657

Summaries for Chronic Closed-Angle Glaucoma

Disease Ontology : 12 A primary angle-closure glaucoma characterized by chronic and progressive narrowing of the anterior chamber angle by an intrinsic defect such that aqueous outflow is blocked and the intraocular pressure becomes inappropriately elevated leading to optic nerve damage and visual field loss. Chronic closed-angle glaucoma has symptom progressive loss of peripheral vision, decreased vision, and occasionally headaches. Chronic closed-angle glaucoma can be caused by anatomically narrow angle, defects in the trabecular meshwork, and iris abnormalities. Primary angle-closure glaucoma has a strong genetic component.

MalaCards based summary : Chronic Closed-Angle Glaucoma, also known as anatomical narrow angle glaucoma, is related to acute closed-angle glaucoma and intraocular pressure quantitative trait locus, and has symptoms including progressive loss of peripheral vision An important gene associated with Chronic Closed-Angle Glaucoma is TGFB2 (Transforming Growth Factor Beta 2). The drugs Pilocarpine and Travoprost have been mentioned in the context of this disorder. Affiliated tissues include eye and endothelial.

Related Diseases for Chronic Closed-Angle Glaucoma

Diseases in the Acute Closed-Angle Glaucoma family:

Glaucoma, Primary Closed-Angle Chronic Closed-Angle Glaucoma

Diseases related to Chronic Closed-Angle Glaucoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Related Disease Score Top Affiliating Genes
1 acute closed-angle glaucoma 30.9 TTLL12 MYOC
2 intraocular pressure quantitative trait locus 30.3 TGFB2 MYOC LOXL1 AQP1
3 glaucoma, primary open angle 30.2 TGFB2 MYOC LOXL1 CAV2
4 corneal edema 30.2 MYOC AQP1
5 ocular hypertension 30.1 TGFB2 MYOC
6 nanophthalmos 30.1 MYOC LOXL1 FOXE3
7 cataract 30.1 TGFB2 LOXL1 FOXE3 AQP1
8 open-angle glaucoma 29.8 TGFB2 MYOC LOXL1 CAV2 AQP1
9 primary angle-closure glaucoma 10.5
10 optic nerve disease 10.5
11 myopia 10.3
12 weill-marchesani syndrome 10.2
13 traumatic glaucoma 10.2 MYOC LOXL1
14 steroid-induced glaucoma 10.2 TGFB2 MYOC
15 neovascular glaucoma 10.2 TGFB2 MYOC
16 glaucoma-related pigment dispersion syndrome 10.2 MYOC LOXL1
17 retinal detachment 10.1
18 retinitis pigmentosa 10.1
19 yemenite deaf-blind hypopigmentation syndrome 10.1
20 microvascular complications of diabetes 5 10.1
21 weill-marchesani syndrome 4 10.1
22 microcephaly, epilepsy, and diabetes syndrome 10.1
23 spastic paraplegia, intellectual disability, nystagmus, and obesity 10.1
24 ifap syndrome 2 10.1
25 exudative vitreoretinopathy 10.1
26 brachydactyly 10.1
27 neuroretinitis 10.1
28 lens subluxation 10.1
29 uveitis 10.1
30 retinal vein occlusion 10.1
31 central retinal vein occlusion 10.1
32 phimosis 10.1
33 retinitis 10.1
34 macular retinal edema 10.1
35 eye disease 10.1
36 scotoma 10.1
37 iridocyclitis 10.1
38 refractive error 10.1
39 vitreoretinopathy 10.1
40 phacogenic glaucoma 10.1 TGFB2 MYOC LOXL1
41 bullous keratopathy 10.0 TGFB2 AQP1
42 oculodentodigital dysplasia 10.0 PANX3 PANX2
43 disuse amblyopia 9.9 SPATA31A3 FOXE3
44 heritable thoracic aortic disease 9.9 TGFB2 FOXE3
45 uveal disease 9.9 MYOC LOXL1
46 glaucoma, normal tension 9.9 MYOC LOXL1 CAV2
47 persistent hyperplastic primary vitreous 9.8 TGFB2 FOXE3
48 iris disease 9.8 MYOC LOXL1 FOXE3
49 juvenile glaucoma 9.8 MYOC LOXL1 FOXE3
50 primary congenital glaucoma 9.8 MYOC LOXL1 FOXE3

Comorbidity relations with Chronic Closed-Angle Glaucoma via Phenotypic Disease Network (PDN):


Glaucoma, Primary Open Angle Hypertension, Essential

Graphical network of the top 20 diseases related to Chronic Closed-Angle Glaucoma:



Diseases related to Chronic Closed-Angle Glaucoma

Symptoms & Phenotypes for Chronic Closed-Angle Glaucoma

Symptoms:

12
  • progressive loss of peripheral vision

Drugs & Therapeutics for Chronic Closed-Angle Glaucoma

Drugs for Chronic Closed-Angle Glaucoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pilocarpine Approved, Investigational Phase 4 54-71-7, 92-13-7 5910
2
Travoprost Approved Phase 4 157283-68-6 5282226
3
Brinzolamide Approved Phase 4 138890-62-7 68844
4 Neurotransmitter Agents Phase 4
5 Muscarinic Agonists Phase 4
6 Cholinergic Agents Phase 4
7 Antihypertensive Agents Phase 4
8 Carbonic Anhydrase Inhibitors Phase 4
9
Latanoprost Approved, Investigational Phase 3 130209-82-4 5282380 5311221
10 Pharmaceutical Solutions Phase 2
11 Ophthalmic Solutions Phase 2
12
Bimatoprost Approved, Investigational 155206-00-1 5311027
13 Mitomycins

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Twelve-Week, Double Masked, Parallel Group, Primary-Therapy Pilot Study of the Safety and Efficacy of Travoprost 0.004% Compared to Pilocarpine 1% in Patients With Chronic Angle-Closure Glaucoma Completed NCT00762645 Phase 4 Travoprost 0.004% (Travatan);Pilocarpine 1%
2 A Double-Masked, Parallel-Group, Efficacy and Safety Study of Brinzolamide 1.0% (AZOPT) as Adjunctive Therapy to Travoprost 0.004% (TRAVATAN) in Patients With Chronic Angle-Closure Glaucoma Terminated NCT00758342 Phase 4 Travoprost 0.004% + Brinzolamide 1.0%;Travoprost 0.004% + Tears Natural
3 A Safety and Efficacy Study of Travoprost 0.004% Compared to Latanoprost 0.005% in Patients With Chronic Angle-Closure Glaucoma. Completed NCT00051181 Phase 3 Travoprost (0.004%);Latanoprost (0.005%)
4 A Prospective Study to Assess the Hypotensive Efficacy of Rho-Kinase Inhibitor AR-12286 Ophthalmic Solution 0.5% and 0.7% in Patients With Chronic Angle-closure Glaucoma Unknown status NCT02152774 Phase 2 Rho-Kinase Inhibitor
5 Prevalence of Chronic Angle Closure in Caucasian Hyperopic Subjects Unknown status NCT00823706
6 Comparison of Bimatoprost and Lataprost in Patients With Chronic Angle-Closure Glaucoma: A Randomized Cross-Over Study Unknown status NCT00567788 Latanoprost-Bimatoprost;Bimatoporost-Latanoprost
7 Sequential Laser Iridotomy Using Argon and Q-Switched 532 nm Frequency Doubled Neodymium Yag Laser: A Pilot Study Completed NCT00452998
8 Phacoemulsification Combined With Trabeculectomy Versus Phacoemulsification Combined With Trabeculotomy for Treatment of Chronic Angle Closure Glaucoma Recruiting NCT04683055

Search NIH Clinical Center for Chronic Closed-Angle Glaucoma

Genetic Tests for Chronic Closed-Angle Glaucoma

Anatomical Context for Chronic Closed-Angle Glaucoma

MalaCards organs/tissues related to Chronic Closed-Angle Glaucoma:

40
Eye, Endothelial

Publications for Chronic Closed-Angle Glaucoma

Articles related to Chronic Closed-Angle Glaucoma:

(show top 50) (show all 331)
# Title Authors PMID Year
1
A phase III study of subconjunctival human anti-transforming growth factor beta(2) monoclonal antibody (CAT-152) to prevent scarring after first-time trabeculectomy. 54 61
17908591 2007
2
Laser peripheral iridoplasty for chronic angle closure. 61
33755197 2021
3
Lens extraction for chronic angle-closure glaucoma. 61
33759192 2021
4
Outcomes of Small Size Ahmed Glaucoma Valve Implantation in Asian Chronic Angle-Closure Glaucoma. 61
33671383 2021
5
Postoperative complicated peripheral cortical cataract after ultrasound cycloplasty: a case report. 61
33413166 2021
6
Outcomes of combined gonioscopy-assisted transluminal trabeculotomy and goniosynechialysis in primary angle closure: a retrospective case series. 61
33392940 2021
7
Bilateral Ocular Ischemic Syndrome in the Setting of Chronic Angle Closure Glaucoma. 61
33394841 2020
8
Profiles and Clinical Characteristics of Newly Diagnosed Glaucoma in Urban Korea: A Multicenter Study. 61
33099556 2020
9
Influence of automated visual field testing on intraocular pressure. 61
32907553 2020
10
Early results of micropulse transscleral cyclophotocoagulation for the treatment of glaucoma. 61
30938190 2020
11
The Effectiveness and Safety of Micropulse Cyclophotocoagulation in the Treatment of Ocular Hypertension and Glaucoma. 61
32672613 2020
12
MicroPulse Transscleral Laser Therapy with Kahook Dual Blade Excisional Goniotomy and Goniosynechialysis Combined with Phacoemulsification for Angle-Closure Glaucoma: A Case Report. 61
33223857 2020
13
Iridoschisis: visual outcome in treated versus untreated eye. 61
32884893 2020
14
Aqueous humor levels of TGFβ2 and SFRP1 in different types of glaucoma. 61
31382918 2019
15
Differential Efficacy of Combined Phacoemulsification and Endocyclophotocoagulation in Open-angle Glaucoma Versus Angle-closure Glaucoma. 61
30839415 2019
16
Anterior Segment Features in Nanophthalmos With Secondary Chronic Angle Closure Glaucoma: An Ultrasound Biomicroscopy Study. 61
31112609 2019
17
Surgical outcomes of phacoemulsification/goniosynechialysis with and without endocyclophotocoagulation in patients with chronic angle closure glaucoma. 61
30777954 2019
18
Indicating and predicting role of the horizontal C/D ratio in preclinical diabetic retinopathy associated with chronic angle-closure glaucoma. 61
30809483 2019
19
Post-miosis changes in the anterior chamber structures in primary and lens-induced secondary chronic angle-closure glaucoma. 61
31024825 2019
20
Primary Outcomes of Patients with Chronic Angle-Closure Glaucoma Treated with Combined Phacoemulsification, Viscogoniosynechialysis, and Endocyclophotocoagulation. 61
31312531 2019
21
RETINAL AND CHOROIDAL VASCULAR OCCLUSION FOLLOWING AQUEOUS MISDIRECTION SYNDROME IN A PATIENT WITH SICKLE CELL TRAIT. 61
28489705 2019
22
Cypass Supraciliary Stent in Eye With Chronic Angle Closure and Postvitrectomy With Silicone Oil. 61
29979341 2018
23
Angle-closure Glaucoma in a Myopic Patient Precipitated by Sexual Excitation: A Case Report. 61
31354207 2018
24
Profile and management outcomes of glaucoma cases at Qassim University Hospital. 61
30202404 2018
25
Factors Associated with Outcomes of Combined Phacoemulsification and Ahmed Glaucoma Valve Implantation. 61
29770636 2018
26
Retinal pigment epithelium changes in Kartagener syndrome. 61
29511746 2018
27
Long-term outcomes after acute primary angle closure of Caucasian chronic angle closure glaucoma patients. 61
28722309 2018
28
Macular Choroidal Small-Vessel Layer, Sattler's Layer and Haller's Layer Thicknesses: The Beijing Eye Study. 61
29535365 2018
29
Refractive outcomes of phacoemulsification cataract surgery in glaucoma patients. 61
29605284 2018
30
Visual Subfield Progression in Glaucoma Subtypes. 61
29750123 2018
31
Longitudinal Change in Peripheral Anterior Chamber Depth of Eyes with Angle Closure after Laser Iridotomy. 61
30671261 2018
32
Ocular pulse amplitude in different types of glaucoma using dynamic contour tonometry: Diagnosis and follow-up of glaucoma. 61
29104631 2017
33
Optic Nerve Head Characteristics in Chronic Angle Closure Glaucoma Detected by Swept-Source OCT. 61
28922031 2017
34
Long-term scanning laser ophthalmoscopy and perimetry in different severities of primary open and chronic angle closure glaucoma eyes. 61
29044061 2017
35
Acute hypotony maculopathy following the initiation of a topical aqueous suppressant in a patient with a history of panuveitis without prior filtering surgery. 61
29260088 2017
36
Intraoperative Optical Coherence Tomography-Assisted Descemet Stripping Automated Endothelial Keratoplasty for Anterior Chamber Fibrous Ingrowth. 61
28399038 2017
37
High intensity focused ultrasound as first line treatment in patients with chronic angle closure glaucoma at risk for malignant glaucoma. 61
28342558 2017
38
Analyzing cytokines as biomarkers to evaluate severity of glaucoma. 61
28730084 2017
39
Peripapillary retinal splitting visualized on OCT in glaucoma and glaucoma suspect patients. 61
28832670 2017
40
Bilateral Same-day Laser Peripheral Iridotomy in the Philadelphia Glaucoma Detection and Treatment Project. 61
26950579 2016
41
Pupillary block due to reverse implantation of a sulcus intraocular lens. 61
28184333 2016
42
Intraoperative floppy-iris syndrome associated with use of antipsychotic drugs. 61
27521670 2016
43
Risk Factors of Disease Progression After Cataract Surgery in Chronic Angle-closure Glaucoma Patients. 61
26550967 2016
44
Efficacy and Safety of Trabectome Surgery in Chinese Open-Angle Glaucoma. 61
27082559 2016
45
The Frequency of Optical Coherence Tomography Testing in Glaucoma at a Single Academic Medical Center. 61
26372155 2016
46
Endoscopic Cyclophotocoagulation and Pars Plana Ablation (ECP-plus) to Treat Refractory Glaucoma. 61
26020690 2016
47
The effect of adjustable suture (Khaw) trabeculectomy on intraocular pressure: a retrospective case series. 61
26002838 2016
48
Case report: imaging and treatment of ophthalmic manifestations in oculodentodigital dysplasia. 61
26743931 2016
49
Comparison of phacotrabeculectomy and sequential surgery in the treatment of chronic angle-closure glaucoma coexisted with cataract. 61
27275422 2016
50
The safety and efficacy of modified minimally invasive trabeculectomy for the treatment of primary chronic angle-closure glaucoma. 61
27215005 2015

Variations for Chronic Closed-Angle Glaucoma

Expression for Chronic Closed-Angle Glaucoma

Search GEO for disease gene expression data for Chronic Closed-Angle Glaucoma.

Pathways for Chronic Closed-Angle Glaucoma

GO Terms for Chronic Closed-Angle Glaucoma

Cellular components related to Chronic Closed-Angle Glaucoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 gap junction GO:0005921 8.62 PANX3 PANX2

Biological processes related to Chronic Closed-Angle Glaucoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 collagen fibril organization GO:0030199 9.26 TGFB2 LOXL1
2 eye development GO:0001654 9.16 TGFB2 FOXE3
3 odontogenesis GO:0042476 8.96 TGFB2 AQP1
4 positive regulation of interleukin-1 production GO:0032732 8.62 PANX3 PANX2

Molecular functions related to Chronic Closed-Angle Glaucoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 gap junction hemi-channel activity GO:0055077 9.16 PANX3 PANX2
2 wide pore channel activity GO:0022829 8.96 PANX3 PANX2
3 channel activity GO:0015267 8.8 PANX3 PANX2 AQP1

Sources for Chronic Closed-Angle Glaucoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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