MCID: CHR054
MIFTS: 28

Chronic Closed-Angle Glaucoma

Categories: Eye diseases

Aliases & Classifications for Chronic Closed-Angle Glaucoma

MalaCards integrated aliases for Chronic Closed-Angle Glaucoma:

Name: Chronic Closed-Angle Glaucoma 12 15
Anatomical Narrow Angle Glaucoma 12 74
Chronic Angle-Closure Glaucoma 12 56
Secondary Angle-Closure Glaucoma - Synechial 74
Chronic Narrow Angle Glaucoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:14445
ICD9CM 36 365.23
SNOMED-CT 69 15417005 33647009
ICD10 34 H40.22

Summaries for Chronic Closed-Angle Glaucoma

MalaCards based summary : Chronic Closed-Angle Glaucoma, also known as anatomical narrow angle glaucoma, is related to glaucoma, primary open angle and cataract. An important gene associated with Chronic Closed-Angle Glaucoma is TGFB2 (Transforming Growth Factor Beta 2). The drugs Latanoprost and Pilocarpine have been mentioned in the context of this disorder. Affiliated tissues include eye, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Chronic Closed-Angle Glaucoma

Diseases in the Acute Closed-Angle Glaucoma family:

Chronic Closed-Angle Glaucoma

Diseases related to Chronic Closed-Angle Glaucoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 16)
# Related Disease Score Top Affiliating Genes
1 glaucoma, primary open angle 29.9 PHEX TGFB2
2 cataract 10.4
3 weill-marchesani syndrome 10.2
4 open-angle glaucoma 10.2
5 retinitis pigmentosa 10.1
6 leber congenital amaurosis 4 10.1
7 microvascular complications of diabetes 5 10.1
8 retinal vein occlusion 10.1
9 exudative vitreoretinopathy 10.1
10 low tension glaucoma 10.1
11 acute closed-angle glaucoma 10.1
12 central retinal vein occlusion 10.1
13 phimosis 10.1
14 retinitis 10.1
15 neovascular glaucoma 9.8 IER3IP1 TGFB2
16 juvenile glaucoma 9.8 PHEX TGFB2

Comorbidity relations with Chronic Closed-Angle Glaucoma via Phenotypic Disease Network (PDN):


Glaucoma, Primary Open Angle Hypertension, Essential

Graphical network of the top 20 diseases related to Chronic Closed-Angle Glaucoma:



Diseases related to Chronic Closed-Angle Glaucoma

Symptoms & Phenotypes for Chronic Closed-Angle Glaucoma

GenomeRNAi Phenotypes related to Chronic Closed-Angle Glaucoma according to GeneCards Suite gene sharing:

27 (show all 18)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-107 9.62 TGFB2
2 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.62 TGFB2
3 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.62 TGFB2
4 Increased shRNA abundance (Z-score > 2) GR00366-A-133 9.62 TGFB2
5 Increased shRNA abundance (Z-score > 2) GR00366-A-138 9.62 TGFB2
6 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.62 CTSA
7 Increased shRNA abundance (Z-score > 2) GR00366-A-196 9.62 TGFB2
8 Increased shRNA abundance (Z-score > 2) GR00366-A-199 9.62 CTSA
9 Increased shRNA abundance (Z-score > 2) GR00366-A-21 9.62 CTSA
10 Increased shRNA abundance (Z-score > 2) GR00366-A-215 9.62 CTSA TGFB2
11 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.62 CTSA
12 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.62 CTSA TGFB2
13 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.62 CTSA TGFB2
14 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.62 TGFB2
15 Increased shRNA abundance (Z-score > 2) GR00366-A-81 9.62 CTSA
16 Increased shRNA abundance (Z-score > 2) GR00366-A-93 9.62 CTSA
17 Increased shRNA abundance (Z-score > 2) GR00366-A-96 9.62 CTSA
18 Decreased caspase 3/7 activity GR00318-A 8.96 CTSA PHEX

MGI Mouse Phenotypes related to Chronic Closed-Angle Glaucoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.13 CTSA PHEX TGFB2
2 renal/urinary system MP:0005367 8.92 AQP7 CTSA PHEX TGFB2

Drugs & Therapeutics for Chronic Closed-Angle Glaucoma

Drugs for Chronic Closed-Angle Glaucoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Latanoprost Approved, Investigational Phase 4,Phase 3,Not Applicable 130209-82-4 5311221 5282380
2
Pilocarpine Approved, Investigational Phase 4 54-71-7, 92-13-7 5910
3
Travoprost Approved Phase 4,Phase 3 157283-68-6 5282226
4
Brinzolamide Approved Phase 4 138890-62-7 68844
5
Timolol Approved Phase 4 26839-75-8 33624 5478
6
SB-649868 Experimental, Investigational Phase 4 110-16-7, 110-17-8 444972
7 Antihypertensive Agents Phase 4,Phase 3,Phase 2,Not Applicable
8 Pharmaceutical Solutions Phase 4,Phase 2
9 Ophthalmic Solutions Phase 4,Phase 2
10 Peripheral Nervous System Agents Phase 4
11 Cholinergic Agents Phase 4
12 Autonomic Agents Phase 4
13 Neurotransmitter Agents Phase 4
14 Muscarinic Agonists Phase 4
15 Carbonic Anhydrase Inhibitors Phase 4
16 Adrenergic alpha-Agonists Phase 4
17 Adrenergic Agents Phase 4
18 Adrenergic Agonists Phase 4
19 Anti-Arrhythmia Agents Phase 4
20 Adrenergic alpha-2 Receptor Agonists Phase 4
21 Adrenergic beta-Antagonists Phase 4
22 Adrenergic Antagonists Phase 4
23 Brimonidine Tartrate, Timolol Maleate Drug Combination Phase 4
24 Brimonidine Tartrate Phase 4 70359-46-5
25
Bimatoprost Approved, Investigational Not Applicable 155206-00-1 5311027

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Travoprost 0.004% Versus Pilocarpine 1% in Patients With Chronic Angle Closure Glaucoma (CACG) Completed NCT00762645 Phase 4 Travoprost 0.004% (Travatan);Pilocarpine 1%
2 Exploratory Study Comparing Signs and Symptoms in Patients With Ocular Hypertension or Glaucoma Using Xalatan R® or Travatan Z® Completed NCT00799682 Phase 4 Xalatan;Travatan Z
3 Azopt (Brinzolamide 1.0%) Plus Travatan (Travoprost 0.004%) in Treating Patients With Chronic Angle-Closure Glaucoma (CACG) Terminated NCT00758342 Phase 4 Travoprost 0.004% + Brinzolamide 1.0%;Travoprost 0.004% + Tears Natural
4 Study of Brimonidine and Timolol Ophthalmic Solution With Latanoprost Compared With Latanoprost in Glaucoma Patients Terminated NCT01151904 Phase 4 brimonidine 0.2%/timolol 0.5% fixed combination ophthalmic solution;latanoprost
5 A Safety and Efficacy Study of Travoprost 0.004% Compared to Latanoprost 0.005% in Patients With Chronic Angle-Closure Glaucoma Completed NCT00051181 Phase 3 Travoprost (0.004%);Latanoprost (0.005%)
6 A Study to Assess the Effect of Rho-Kinase Inhibitor AR-12286 Ophthalmic Solution 0.5% and 0.7% in Patients With Chronic Angle-closure Glaucoma Unknown status NCT02152774 Phase 2 Rho-Kinase Inhibitor
7 Comparison of Bimatoprost and Latanoprost in Patients With Chronic Angle-Closure Glaucoma: A Randomized Cross-Over Study Unknown status NCT00567788 Not Applicable Latanoprost-Bimatoprost;Bimatoporost-Latanoprost
8 Prevalence of Angle Closure in Caucasian Hyperopes Unknown status NCT00823706
9 Biometry of Occult Lens Subluxation Misdiagnosed as Primary Acute Angle Closed Glaucoma Completed NCT03752710
10 Sequential Laser Iridotomy Using Argon and Q-Switched 532 nm Frequency Doubled Neodymium Yag Laser: A Pilot Study Completed NCT00452998 Not Applicable
11 Advanced Glaucoma Progression Study Active, not recruiting NCT01742819

Search NIH Clinical Center for Chronic Closed-Angle Glaucoma

Genetic Tests for Chronic Closed-Angle Glaucoma

Anatomical Context for Chronic Closed-Angle Glaucoma

MalaCards organs/tissues related to Chronic Closed-Angle Glaucoma:

42
Eye

Publications for Chronic Closed-Angle Glaucoma

Articles related to Chronic Closed-Angle Glaucoma:

(show all 19)
# Title Authors Year
1
Indicating and predicting role of the horizontal C/D ratio in preclinical diabetic retinopathy associated with chronic angle-closure glaucoma. ( 30809483 )
2019
2
Comparison of phacotrabeculectomy and sequential surgery in the treatment of chronic angle-closure glaucoma coexisted with cataract. ( 27275422 )
2016
3
Risk Factors of Disease Progression After Cataract Surgery in Chronic Angle-closure Glaucoma Patients. ( 26550967 )
2016
4
The safety and efficacy of modified minimally invasive trabeculectomy for the treatment of primary chronic angle-closure glaucoma. ( 27215005 )
2015
5
Rapid anterior capsular phimosis after cataract surgery in a patient with chronic angle closure glaucoma. ( 29018698 )
2015
6
Interocular Asymmetry of the Visual Field Defects in Newly Diagnosed Normal-tension Glaucoma, Primary Open-angle Glaucoma, and Chronic Angle-closure Glaucoma. ( 23632403 )
2013
7
Phacoemulsification versus trabeculectomy in medically uncontrolled chronic angle-closure glaucoma without cataract. ( 23823520 )
2013
8
Diode Laser Cyclophotocoagulation for Nanophthalmic Chronic Angle Closure Glaucoma. ( 23807357 )
2013
9
Patterns of damage in chronic angle-closure glaucoma compared to primary open-angle glaucoma. ( 21470591 )
2011
10
Weill Marchesani syndrome with chronic angle closure glaucoma in Ethiopia: a case report. ( 19743786 )
2009
11
Optic nerve head morphologic characteristics in chronic angle-closure glaucoma and normal-tension glaucoma. ( 19680054 )
2009
12
Phacoemulsification versus combined phacotrabeculectomy in medically uncontrolled chronic angle closure glaucoma with cataracts. ( 19243831 )
2009
13
Chronic angle-closure glaucoma secondary to a suprachoroidal effusion induced by central retinal vein occlusion. ( 17552395 )
2007
14
Surgical treatment of advanced chronic angle closure glaucoma in Weill-Marchesani syndrome. ( 15478742 )
2004
15
Combined phacoemulsification and goniosynechialysis for uncontrolled chronic angle-closure glaucoma after acute angle-closure glaucoma. ( 10201585 )
1999
16
Familial exudative vitreoretinopathy associated with nonneovascular chronic angle-closure glaucoma. ( 9075081 )
1997
17
Filtering iridocycloretraction in chronic closed-angle glaucoma. ( 3976810 )
1985
18
Sector retinitis pigmentosa and chronic angle-closure glaucoma: a new association. ( 6472800 )
1984
19
Some observations on chronic closed-angle glaucoma. ( 13413136 )
1957

Variations for Chronic Closed-Angle Glaucoma

Expression for Chronic Closed-Angle Glaucoma

Search GEO for disease gene expression data for Chronic Closed-Angle Glaucoma.

Pathways for Chronic Closed-Angle Glaucoma

GO Terms for Chronic Closed-Angle Glaucoma

Biological processes related to Chronic Closed-Angle Glaucoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 8.96 PHEX TGFB2
2 skeletal system development GO:0001501 8.62 PHEX TGFB2

Sources for Chronic Closed-Angle Glaucoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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