Chronic Closed-Angle Glaucoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: CHR054 MIFTS: 42	Chronic Closed-Angle Glaucoma Categories: Eye diseases
Genes Tissues Related diseases Publications Pathways Drugs Expand all tables

Sources

Aliases & Classifications for Chronic Closed-Angle Glaucoma

MalaCards integrated aliases for Chronic Closed-Angle Glaucoma:

Name: Chronic Closed-Angle Glaucoma ¹² ¹⁵

Anatomical Narrow Angle Glaucoma ¹² ⁷²

Chronic Angle-Closure Glaucoma ¹² ⁵⁵

Secondary Angle-Closure Glaucoma - Synechial ⁷²

Chronic Narrow Angle Glaucoma ¹²

Classifications:

MalaCards categories:
Anatomical: Eye diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:14445

ICD9CM ³⁵ 365.23

SNOMED-CT ⁶⁸ 15417005 33647009

ICD10 ³³ H40.22

UMLS ⁷² C0154947 C1272657

Sources

Summaries for Chronic Closed-Angle Glaucoma

MalaCards based summary : Chronic Closed-Angle Glaucoma, also known as anatomical narrow angle glaucoma, is related to optic nerve disease and cataract. An important gene associated with Chronic Closed-Angle Glaucoma is TGFB2 (Transforming Growth Factor Beta 2), and among its related pathways/superpathways are NF-KappaB Family Pathway and Nanog in Mammalian ESC Pluripotency. The drugs Pilocarpine and Travoprost have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and endothelial, and related phenotypes are cardiovascular system and growth/size/body region

Sources

Related Diseases for Chronic Closed-Angle Glaucoma

Diseases in the Acute Closed-Angle Glaucoma family:

Chronic Closed-Angle Glaucoma

Diseases related to Chronic Closed-Angle Glaucoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)

#	Related Disease	Score	Top Affiliating Genes
1	optic nerve disease	30.3	MYOC EDN1 AQP4
2	cataract	10.7
3	acute closed-angle glaucoma	10.6
4	primary angle-closure glaucoma	10.5
5	open-angle glaucoma	10.5
6	intraocular pressure quantitative trait locus	10.4
7	glaucoma, primary open angle	10.4
8	multilocular clear cell renal cell carcinoma	10.4	TGFB3 TGFB2
9	myopia	10.3
10	weill-marchesani syndrome	10.3
11	hydrarthrosis	10.2	AQP7 AQP3 AQP1
12	chronic gonococcal salpingitis	10.2	TNFRSF1A CTSA
13	retinal detachment	10.1
14	retinitis pigmentosa	10.1
15	yemenite deaf-blind hypopigmentation syndrome	10.1
16	microvascular complications of diabetes 5	10.1
17	weill-marchesani syndrome 4	10.1
18	microcephaly, epilepsy, and diabetes syndrome	10.1
19	spastic paraplegia, intellectual disability, nystagmus, and obesity	10.1
20	exudative vitreoretinopathy	10.1
21	brachydactyly	10.1
22	neuroretinitis	10.1
23	corneal edema	10.1
24	lens subluxation	10.1
25	uveitis	10.1
26	retinal vein occlusion	10.1
27	central retinal vein occlusion	10.1
28	phimosis	10.1
29	retinitis	10.1
30	macular retinal edema	10.1
31	eye disease	10.1
32	ocular hypertension	10.1
33	scotoma	10.1
34	refractive error	10.1
35	anterior uveitis	10.1
36	obsolete: brachydactyly of fingers	10.1
37	vitreoretinopathy	10.1
38	diabetes insipidus, nephrogenic, autosomal	10.0	AQP4 AQP3 AQP1
39	loeys-dietz syndrome 4	10.0	TGFB3 TGFB2
40	diffuse pulmonary fibrosis	10.0	TIMP1 BMP7 AQP5
41	central pontine myelinolysis	10.0	AQP4 AQP1
42	oligohydramnios	9.8	EDN1 AQP3 AQP1
43	meniere disease	9.7	AQP7 AQP5 AQP4 AQP3 AQP1
44	demyelinating disease	9.7	TNFRSF1A CXCL10 AQP4
45	microvascular complications of diabetes 1	9.6	TIMP1 TGFB2 EDN1
46	tendinosis	9.5	TNFRSF1A TIMP1 TGFB2 CXCL10

Comorbidity relations with Chronic Closed-Angle Glaucoma via Phenotypic Disease Network (PDN):

Glaucoma, Primary Open Angle

Hypertension, Essential

Graphical network of the top 20 diseases related to Chronic Closed-Angle Glaucoma:

Sources

Symptoms & Phenotypes for Chronic Closed-Angle Glaucoma

MGI Mouse Phenotypes related to Chronic Closed-Angle Glaucoma:

⁴⁶ (show all 18)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cardiovascular system	MP:0005385	10.42	AQP1 AQP3 AQP4 BMP7 CTSA CXCL10
2	growth/size/body region	MP:0005378	10.41	AQP1 AQP3 AQP4 AQP5 AQP7 BMP7
3	homeostasis/metabolism	MP:0005376	10.34	AQP1 AQP3 AQP4 AQP5 AQP7 CTSA
4	mortality/aging	MP:0010768	10.31	AQP1 AQP3 AQP4 AQP5 BMP7 CTSA
5	endocrine/exocrine gland	MP:0005379	10.29	AQP1 AQP4 AQP5 AQP7 BMP7 EDN1
6	hematopoietic system	MP:0005397	10.25	AQP1 AQP4 BMP7 CTSA CXCL10 GJA1
7	craniofacial	MP:0005382	10.22	AQP3 BMP7 CTSA EDN1 GJA1 SFRP1
8	immune system	MP:0005387	10.22	AQP3 AQP4 BMP7 CTSA CXCL10 GJA1
9	digestive/alimentary	MP:0005381	10.16	AQP3 AQP4 AQP5 BMP7 EDN1 TGFB2
10	nervous system	MP:0003631	10.14	AQP1 AQP4 BMP7 CXCL10 EDN1 GJA1
11	hearing/vestibular/ear	MP:0005377	10.13	AQP1 AQP3 AQP4 AQP5 BMP7 EDN1
12	limbs/digits/tail	MP:0005371	10	BMP7 GJA1 SFRP1 TGFB2 TGFB3 TIMP1
13	renal/urinary system	MP:0005367	9.97	AQP1 AQP3 AQP4 AQP7 BMP7 CTSA
14	no phenotypic analysis	MP:0003012	9.91	AQP4 AQP5 GJA1 KIDINS220 MYOC SFRP1
15	reproductive system	MP:0005389	9.91	AQP1 AQP7 BMP7 CTSA GJA1 SFRP1
16	respiratory system	MP:0005388	9.9	AQP1 AQP3 AQP4 AQP5 BMP7 CTSA
17	skeleton	MP:0005390	9.65	AQP1 AQP3 BMP7 EDN1 GJA1 SFRP1
18	vision/eye	MP:0005391	9.36	AQP1 AQP3 AQP4 AQP5 BMP7 GJA1

Sources

Drugs & Therapeutics for Chronic Closed-Angle Glaucoma

Drugs for Chronic Closed-Angle Glaucoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Pilocarpine

Approved, Investigational

Phase 4

92-13-7, 54-71-7

5910

Synonyms:

(+)-Pilocarpine

(3S,4R)-3-ethyl-4-[(1-methyl-1H-imidazol-5-yl)methyl]dihydrofuran-2(3H)-one

(3S,4R)-3-ethyl-4-[(3-methylimidazol-4-yl)methyl]oxolan-2-one

(3S,4R)-3-ethyldihydro-4-((1-methyl-1H-imidazol-5-yl)methyl)-2(3H)-furanone

(3S,4R)-3-ethyldihydro-4-((1-Methyl-1H-imidazol-5-yl)methyl)-2(3H)-furanone

(3S-cis)-3-Ethyldihydro-4-((1-methyl-1H-imidazol-5-yl)methyl)-2(3H)-furanone

(3S-cis)-3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-2(3H)-furanone

(3S-cis)-3-ethyldihydro-4-[(1-Methyl-1H-imidazol-5-yl)methyl]-2(3H)-furanone

3-ethyl-4-((1-methyl-1H-imidazol-5-yl)methyl)dihydro-2(3H)-furanone

3-Ethyl-4-(3-methyl-3H-imidazol-4-ylmethyl)dihydrofuran-2-one

3-Ethyl-4-[(1-methyl-1H-imidazol-5-yl)methyl]dihydro-2(3H)-furanone

3-Ethyl-4-[(1-methyl-1H-imidazol-5-yl)methyl]dihydrofuran-2(3H)-one

3-ethyl-4-[(3-methylimidazol-4-yl)methyl]oxolan-2-one

54-71-7

91484-73-0

92-13-7

AC1L1J0W

AC1L1LEF

AC1Q6MOP

Adsorbocarpine

AI3-50523

Almocarpine

Amistura P

AR-1F3128

beta-Pilocarpine hydrochloride

BIDD:GT0217

BPBio1_000548

BRD-K85090592-008-05-2

BSPBio_000498

BSPBio_002191

C07474

CHEBI:39460

CHEBI:8207

CHEMBL550

CID4819

CID5910

D00525

DB01085

DivK1c_000358

EINECS 202-128-4

Epicar

HMS2089K17

HSDB 3163

Hydrochloride, pilocarpine

IDI1_000358

Imidazole-5-butyric acid, alpha-ethyl-beta-(hydroxymethyl)-1-methyl-, gamma-lactone

isopilocarpine

Isopilocarpine

Isopto carpine

Isoptocarpine

KBio1_000358

KBio2_001587

KBio2_004155

KBio2_006723

KBio3_001691

KBioGR_000956

KBioSS_001587

L001181

Lopac0_000950

Lopac0_000960

LS-187208

LS-7661

Minims Pilocarpine

Miocarpine

Mi-Pilo

MolPort-002-512-506

NCGC00023339-03

NCGC00023339-06

NCGC00023339-07

NCGC00023339-08

NCGC00023339-09

NCGC00023339-12

NCGC00023339-13

nchembio.78-comp9

NCI60_004403

NINDS_000358

Nitrate, pilocarpine

NSC5746

Ocu-Carpine

Ocusert

Ocusert P 20

Ocusert pilo

Ocusert pilo-20

Ocusert pilo-20 (TN)

Ocusert Pilo-40

P.V. Carpine Liquifilm

Pilagan

Pilocarpin

Pilocarpina

pilocarpine

Pilocarpine

Pilocarpine (JAN/USP)

Pilocarpine [USAN:BAN:JAN]

Pilocarpine chloride

Pilocarpine HCl

Pilocarpine HCL

Pilocarpine hydrochloride

Pilocarpine monohydrochloride

Pilocarpine mononitrate, (3S-cis)-isomer

Pilocarpine Mononitrate, (3S-cis)-Isomer

Pilocarpine muriate

Pilocarpine nitrate

Pilocarpine, monohydrochloride, (3S-cis)-isomer

Pilocarpine, Monohydrochloride, (3S-cis)-Isomer

Pilocarpol

Pilokarpin

Pilokarpin monohydrochloride

Pilokarpol

Piloptic-1

Piloptic-1/2

Piloptic-2

Piloptic-3

Piloptic-4

Piloptic-6

Pilostat

Prestwick0_000449

Prestwick1_000449

Prestwick2_000449

Prestwick3_000449

Salagen

SDCCGMLS-0003164.P005

SPBio_001287

SPBio_002437

Spectrum_001107

Spectrum2_001284

Spectrum3_000546

Spectrum4_000478

Spectrum5_001379

Spersacarpine

Spersacarpine hydrochloride

STOCK1N-18408

Syncarpine

Tocris-0694

UNII-01MI4Q9DI3

ZINC00075008

Travoprost

Approved

Phase 4

157283-68-6

5282226

Synonyms:

(((1R)-(1alpha(Z),2beta(1E,3R*),3alpha,5alpha))-7-(3,5-dihydroxy-2-(3-hydroxy-4-(3-trifluoromethyl)phenoxy)-1-butenyl)cyclopentyl)-5-heptenoic acid, 1-methylethyl ester

(+)-Fluprostenol isopropyl ester

(1R-(1alpha(Z),2beta(1E,3R*),3alpha,5alpha))-7-(3,5-Dihydroxy-2-(3-hydroxy-4-(3-(trifluoromethyl)phenoxy)-1-butenyl)cyclopentyl)-5-heptenoic acid, 1-methylethyl ester

(Z)-7-((1R,2R,3R,5S)-3,5-Dihydroxy-2-((1E,3R)-3-hydroxy-4-((alpha,alpha,alpha-trifluoro-m-isopropyl-tolyl)oxy)-1-butenyl)cyclopentyl)-5-heptenoate

157283-68-6

5-Heptenoic acid,7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((1E,3R)-3-hydroxy-4-(3-(trifluoromethyl)phenoxy)-1-butenyl)cyclopentyl)-,1-methylethyl ester,(5Z)

AC1NQZOS

AC-6103

AL6221

AL-6221

C26H35F3O6

CHEBI:746859

CHEMBL1200799

CID5282226

D01964

DB00287

Isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-{(1E,3R)-3-hydroxy-4-[(a,a,a-trifluoro-m-tolyl)oxy]-1-butenyl}cyclopentyl)-5-heptenoate

Isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-{(1E,3R)-3-hydroxy-4-[(a,a,a-trifluoro-m-tolyl)oxy]-1-butenyl}cyclopentyl)-5-heptenoic acid

isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-{(1E,3R)-3-hydroxy-4-[(alpha,alpha,alpha-trifluoro-m-tolyl)oxy]-1-butenyl}cyclopentyl)-5-heptenoate

Isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-{(1E,3R)-3-hydroxy-4-[(alpha,alpha,alpha-trifluoro-m-tolyl)oxy]-1-butenyl}cyclopentyl)-5-heptenoate

Isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-{(1E,3R)-3-hydroxy-4-[(alpha,alpha,alpha-trifluoro-m-tolyl)oxy]-1-butenyl}cyclopentyl)-5-heptenoic acid

isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-{(1E,3R)-3-hydroxy-4-[(α,α,α-trifluoro-m-tolyl)oxy]-1-butenyl}cyclopentyl)-5-heptenoate

Isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-{(1E,3R)-3-hydroxy-4-[(α,α,α-trifluoro-m-tolyl)oxy]-1-butenyl}cyclopentyl)-5-heptenoate

Isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-{(1E,3R)-3-hydroxy-4-[(α,α,α-trifluoro-m-tolyl)oxy]-1-butenyl}cyclopentyl)-5-heptenoic acid

LS-173521

propan-2-yl (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-{(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-en-1-yl}cyclopentyl]hept-5-enoate

propan-2-yl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-enyl]cyclopentyl]hept-5-enoate

S1554_Selleck

Travatan

Travatan (TN)

Travatan Alcon

Travatan Z

Travatan, Travoprost

Travatanz

Travoprost

Travoprost (JAN/USAN/INN)

Travoprost [USAN]

Travoprostum

Z, Travatan

ZINC04474682

Latanoprost

Approved, Investigational

Phase 4

130209-82-4

5282380 5311221

Synonyms:

130209-82-4

AC1NSK8Q

Ambap130209-82-4

AR-202

Catioprost

CHEBI:6384

CHEMBL1051

CID5311221

CPD000466354

D00356

HMS2051H11

HMS2089J17

isopropyl (5Z,9alpha,11alpha,15R)-9,11,15-trihydroxy-17-phenyl-18,19,20-trinorprost-5-en-1-oate

Isopropyl (5Z,9alpha,11alpha,15R)-9,11,15-trihydroxy-17-phenyl-18,19,20-trinor-prost-5-en-1-oate

isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((3R)-3-hydroxy-5-phenylpentyl)cyclopentyl)-5-heptenoate

Isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((3R)-3-hydroxy-5-phenylpentyl)cyclopentyl)-5-heptenoate

Isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((3R)-3-hydroxy-5-phenylpentyl)cyclopentyl)-5-heptenoic acid

Jsp001835

L1167_SIGMA

latanoprost

Latanoprost

Latanoprost (JAN/USAN/INN)

latanoprost free acid

Latanoprostum

MLS000759468

MLS001424106

MolPort-003-942-862

Nova-21027

Pfizer brand OF latanoprost

PhXA 41

PhXA34

PhXA34 [as 15(R,S)-isomer]

PhXA41

PHXA41

PHXA-41

propan-2-yl (5Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl}hept-5-enoate

Propan-2-yl (5Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl}hept-5-enoate

Propan-2-yl (5Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl}hept-5-enoic acid

propan-2-yl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]hept-5-enoate

S1254_Selleck

SAM001246671

SMR000466354

TL8000716

XA41

XA-41

Xalatan

Xalatan (TN)

Xalatan Fixed Flow Device

ZINC12468792

Timolol

Approved

Phase 4

26839-75-8

33624 5478

Synonyms:

(-)-3-Morpholino-4-(3-tert-butylamino-2-hydroxypropoxy)-1,2,5-thiadiazole

(2S)-1-((1,1-dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl)oxy)-2-propanol

(2S)-1-(tert-butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol

(2S)-1-[(1,1-dimethylethyl)amino]-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol

(S)-1-(1,1-(Dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl)oxy)-2-propanol

(S)-1-(tert-Butylamino)-3-((4-morpholino-1,2,5-thiadiazol-3-yl)oxy)propan-2-ol

(S)-1-(tert-butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol

(S)-timolol

131628-37-0

194288-09-0

26839-75-8

26921-17-5 (maleate (1:1) salt)

AB00513729

AC1L1PYN

AC1Q59QM

Apo-Timol

Apo-Timop

Aquanil

Betim

Betimol

Betimol (TN)

BIDD:GT0073

Blocadren

BPBio1_001008

BRD-K08806317-050-03-6

BSPBio_000916

C07141

C13H24N4O3S

CAS-26921-17-5

CHEBI:9599

CHEMBL499

CID33624

CPD001456519

D08600

DB00373

DB08625

EINECS 248-032-6

HMS2089I11

HSDB 6533

Istalol

L-714,465

Lopac0_001189

Lopac-T-6394

LS-122231

MK-950

NCGC00016038-01

NCGC00016038-02

NCGC00016798-01

NCGC00016798-07

NCGC00022033-02

NCGC00022033-04

NCGC00022033-05

Novo-Timol

Nu-Timolol

Oprea1_640981

Optimol

Phoxal-timolol

Prestwick0_000948

Prestwick1_000948

Prestwick2_000948

Prestwick3_000948

Proflax

S-(-)-3-(3-tert-Butylamino-2-hydroxypropoxy)-4-morpholino-1,2,5-thiadiazole

S(-)-Timolol maleate

SAM002564238

SPBio_003075

ST072193

Temserin

Tenopt

TIM

Timacar

Timacor

Tim-AK

timolol

Timolol

Timolol (INN)

Timolol (TN)

Timolol [USAN]

Timolol anhydrous

Timolol GFS

Timolol maleate

Timolol Maleate, (1:1) Salt

Timololo

Timololum

Timololum [INN-Latin]

Timopic

Timoptic

Timoptic in Ocudose

Timoptic OcuDose

Timoptic-XE

Timoptol

Tocris-0649

UNII-817W3C6175

Brinzolamide

Approved

Phase 4

138890-62-7

68844

Synonyms:

(+)-4-ETHYLAMINO-3,4-DIHYDRO-2-(METHOXY)PROPYL-2H-THIENO[3,2-E]-1,2-THIAZINE-6-SULFONAMIDE-1,1-DIOXIDE

(4R)-4-(ethylamino)-2-(3-methoxypropyl)-1,1-dioxo-3,4-dihydrothieno[3,2-e]thiazine-6-sulfonamide

(4R)-4-(ethylamino)-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide

(R)-4-(ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-2H-thieno(3,2-e)-1,2-thiazine-6-sulfonamide

(R)-4-(Ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-2H-thieno(3,2-e)-1,2-thiazine-6-sulfonamide 1,1-dioxide

138890-62-7

2H-Thieno(3,2-e)-1,2-thiazine-6-sulfonamide,4-(ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-,1,1-dioxide,R

3znc

AB00513824

AC1L2AKA

AC1Q6UVB

AC-5277

AKOS005145708

AL 4862

AL04862

AL-4862

Alcon brand of brinzolamide

Alcon brand OF brinzolamide

Allphar brand of brinzolamide

Allphar brand OF brinzolamide

Azopt

Azopt (TN)

BIDD:GT0039

Birnzolamide

BPBio1_000539

BRD-K74913225-001-03-3

Brinzolamida

Brinzolamide

Brinzolamide (BRZ)

Brinzolamide (JAN/USP/INN)

Brinzolamide [USAN]

BSPBio_000489

BZ1

C07760

C111827

C12H21N3O5S3

CHEBI:3176

CHEMBL220491

CID68844

D00652

DB01194

FT-0082471

HMS1569I11

I09-0605

LS-173036

MLS002153787

MolPort-005-940-291

Prestwick0_000365

Prestwick1_000365

Prestwick2_000365

Prestwick3_000365

SMR001233169

SPBio_002410

UNII-9451Z89515

Maleic acid

Experimental, Investigational

Phase 4

110-17-8, 110-16-7

444972

Synonyms:

(2E)-2-Butenedioate

(2E)-2-butenedioic acid

(2E)-2-Butenedioic acid

(2E)-But-2-enedioate

(2E)-but-2-enedioic acid

(2E)-But-2-enedioic acid

(e)-2-Butenedioate

(e)-2-Butenedioic acid

(E)-2-butenedioic acid

(E)-2-Butenedioic acid

(E)-but-2-enedioic acid

03761_FLUKA

1,2-Ethylenedicarboxylic acid, (E)

110-17-8

2-(e)-Butenedioate

2-(e)-Butenedioic acid

2-(E)-Butenedioic acid

240745_ALDRICH

240745_SIAL

26B3632D-E93F-4655-90B0-3C17855294BA

2-Butenedioic acid

2-Butenedioic acid (2E)- (9CI)

4-02-00-02202 (Beilstein Handbook Reference)

623158-97-4

AB1002616

AC1L9H76

AC1Q5T7Y

AC1Q71EM

Acidum fumaricum

AI3-24236

AKOS000118896

Allomaleate

Allomaleic acid

Allomalenic acid

ammonium fumarate

Ammonium fumarate

AR-1D9767

bmse000083

Boletate

Boletic acid

BRN 0605763

But-2-enedioic acid

Butenedioic acid

C00122

C4H4O4

Caswell No. 465E

CCRIS 1039

CHEBI:18012

CHEBI:22958

CHEMBL503160

CID444972

D02308

DB04299

e297

E-2-Butenedioic acid

EINECS 203-743-0

EPA Pesticide Chemical Code 051201

F0067

F8509_SIGMA

FC 33

FC 33 (acid)

FEMA No. 2488

FEMA Number 2488

fum

fumarate

Fumarate

fumarate, 10

fumaric acid

Fumaric acid (8CI)

Fumaric acid (NF)

Fumaricum acidum

Fumarsaeure

Fumarsäure

Furamag

HSDB 710

I04-1070

Kyselina fumarova

Kyselina fumarova [Czech]

Lichenate

Lichenic acid

Lichenic acid (VAN)

LMFA01170106

LS-500

Magnesium fumarate

MLS002454406

MolPort-001-780-031

MolPort-004-288-293

NCGC00091192-01

nchembio.186-comp71

nchembio.2007.47-comp1

NSC2752

NSC-2752

OR17920

S04-0167

SMR000112117

Sodium fumarate

trans-1,2-Ethylenedicarboxylate

trans-1,2-ethylenedicarboxylic acid

trans-1,2-Ethylenedicarboxylic acid

trans-2-Butenedioate

trans-2-Butenedioic acid

trans-But-2-enedioate

trans-but-2-enedioic acid

trans-But-2-enedioic acid

trans-Butenedioate

trans-Butenedioic acid

Tumaric acid

U-1149

UNII-88XHZ13131

USAF EK-P-583

W248800_ALDRICH

WLN: QV1U1VQ-T

Cholinergic Agents

Phase 4

Peripheral Nervous System Agents

Phase 4

Muscarinic Agonists

Phase 4

Autonomic Agents

Phase 4

Antihypertensive Agents

Phase 4

Ophthalmic Solutions

Phase 4

Pharmaceutical Solutions

Phase 4

Neurotransmitter Agents

Phase 4

Adrenergic alpha-2 Receptor Agonists

Phase 4

Adrenergic alpha-Agonists

Phase 4

Adrenergic Agonists

Phase 4

Adrenergic beta-Antagonists

Phase 4

Adrenergic Antagonists

Phase 4

Adrenergic Agents

Phase 4

Anti-Arrhythmia Agents

Phase 4

Brimonidine Tartrate

Phase 4

70359-46-5

Brimonidine Tartrate, Timolol Maleate Drug Combination

Phase 4

Carbonic Anhydrase Inhibitors

Phase 4

Bimatoprost

Approved, Investigational

155206-00-1

5311027

Synonyms:

(5Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-5-phenylpent-1-en-1-yl]cyclopentyl}-N-ethylhept-5-enamide

(Z)-7-((1R,2R,3R,5S)-3,5-Dihydroxy-2-((1E,3S)-3-hydroxy-5-phenyl-1-pentenyl)cyclopentyl)-N-ethyl-5-heptenamide

(Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-hydroxy-5-phenylpent-1-enyl]cyclopentyl]-N-ethylhept-5-enamide

155206-00-1

15M

267244-98-4

5-Heptenamide,7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((1E,3S)-3-hydroxy-5-phenyl-1-pentenyl)cyclopentyl)-N-ehtyl-,(5Z)

AC1NSJUW

AGN 192024

AGN-192024

Bimataprost [USAN:INN:BAN]

Bimatoprost

Bimatoprost (JAN/USAN/INN)

Bimatoprost [USAN:INN:BAN]

bimatoprostum

Bimatoprostum

CHEBI:39562

CHEBI:51230

CHEMBL1200963

CID5311027

D02724

DB00905

DB06863

I06-1275

I06-1277

Latisse

LS-181817

Lumigan

Lumigan (TN)

NCGC00181745-01

UNII-QXS94885MZ

ZINC04474405

Interventional clinical trials:

(show all 12)

#	Name	Status	NCT ID	Phase	Drugs
1	A Twelve-Week, Double Masked, Parallel Group, Primary-Therapy Pilot Study of the Safety and Efficacy of Travoprost 0.004% Compared to Pilocarpine 1% in Patients With Chronic Angle-Closure Glaucoma	Completed	NCT00762645	Phase 4	Travoprost 0.004% (Travatan);Pilocarpine 1%
2	An 8 Week, Single Masked, Parallel-Group, Exploratory Study Comparing Ocular Surface Signs and Symptoms in Monotherapy Ocular Hypertension or Glaucoma Patients Randomized to Either Xalatan® or Travatan Z®	Completed	NCT00799682	Phase 4	Xalatan;Travatan Z
3	Study of Brimonidine and Timolol Ophthalmic Solution With Latanoprost Compared With Latanoprost in Glaucoma Patients	Terminated	NCT01151904	Phase 4	brimonidine 0.2%/timolol 0.5% fixed combination ophthalmic solution;latanoprost
4	A Double-Masked, Parallel-Group, Efficacy and Safety Study of Brinzolamide 1.0% (AZOPT) as Adjunctive Therapy to Travoprost 0.004% (TRAVATAN) in Patients With Chronic Angle-Closure Glaucoma	Terminated	NCT00758342	Phase 4	Travoprost 0.004% + Brinzolamide 1.0%;Travoprost 0.004% + Tears Natural
5	A Safety and Efficacy Study of Travoprost 0.004% Compared to Latanoprost 0.005% in Patients With Chronic Angle-Closure Glaucoma.	Completed	NCT00051181	Phase 3	Travoprost (0.004%);Latanoprost (0.005%)
6	A Prospective Study to Assess the Hypotensive Efficacy of Rho-Kinase Inhibitor AR-12286 Ophthalmic Solution 0.5% and 0.7% in Patients With Chronic Angle-closure Glaucoma	Unknown status	NCT02152774	Phase 2	Rho-Kinase Inhibitor
7	Prevalence of Chronic Angle Closure in Caucasian Hyperopic Subjects	Unknown status	NCT00823706
8	Comparison of Bimatoprost and Lataprost in Patients With Chronic Angle-Closure Glaucoma: A Randomized Cross-Over Study	Unknown status	NCT00567788		Latanoprost-Bimatoprost;Bimatoporost-Latanoprost
9	Biometric Indicators of Eyes With Occult Lens Subluxation	Completed	NCT03752710
10	Angle Closure: Laser Iridotomy Versus Phacoemulsification Study (ACLIPS)- A Study of Acute Primary Angle Closure Glaucoma Comparing Two Treatment Modalities: Laser Peripheral vs Phacoemulsification With Posterior Intraocular Lens Implant	Completed	NCT00350428
11	Comparison Study of Glaucoma Eye Care Follow-Up Adherence in a High Risk Population	Completed	NCT02347670
12	Sequential Laser Iridotomy Using Argon and Q-Switched 532 nm Frequency Doubled Neodymium Yag Laser: A Pilot Study	Completed	NCT00452998

Search NIH Clinical Center for Chronic Closed-Angle Glaucoma

Inferred drug relations via UMLS ⁷² / NDF-RT ⁵¹ :

Echothiophate

Sources

Genetic Tests for Chronic Closed-Angle Glaucoma

Sources

Anatomical Context for Chronic Closed-Angle Glaucoma

MalaCards organs/tissues related to Chronic Closed-Angle Glaucoma:

⁴¹

Eye, Testes, Endothelial

Sources

Publications for Chronic Closed-Angle Glaucoma

Articles related to Chronic Closed-Angle Glaucoma:

(show top 50) (show all 320)

#	Title	Authors	PMID	Year
1	A phase III study of subconjunctival human anti-transforming growth factor beta(2) monoclonal antibody (CAT-152) to prevent scarring after first-time trabeculectomy. ⁹ ³⁸	CAT-152 0102 Trabeculectomy Study Group...Smith Z	17908591	2007
2	Aqueous humor levels of TGFβ2 and SFRP1 in different types of glaucoma. ³⁸	Guo T...Fan X	31382918	2019
3	Differential Efficacy of Combined Phacoemulsification and Endocyclophotocoagulation in Open-angle Glaucoma Versus Angle-closure Glaucoma. ³⁸	Lin MM...Chen TC	30839415	2019
4	Anterior Segment Features in Nanophthalmos With Secondary Chronic Angle Closure Glaucoma: An Ultrasound Biomicroscopy Study. ³⁸	Guo C...Fan Z	31112609	2019
5	Early results of micropulse transscleral cyclophotocoagulation for the treatment of glaucoma. ³⁸	Nguyen AT...Noecker RJ	30938190	2019
6	Surgical outcomes of phacoemulsification/goniosynechialysis with and without endocyclophotocoagulation in patients with chronic angle closure glaucoma. ³⁸	Panse K...Ayyala RS	30777954	2019
7	Primary Outcomes of Patients with Chronic Angle-Closure Glaucoma Treated with Combined Phacoemulsification, Viscogoniosynechialysis, and Endocyclophotocoagulation. ³⁸	Izquierdo Villavicencio JC...Mejias Smith J	31312531	2019
8	Post-miosis changes in the anterior chamber structures in primary and lens-induced secondary chronic angle-closure glaucoma. ³⁸	Li M...Zhang H	31024825	2019
9	Indicating and predicting role of the horizontal C/D ratio in preclinical diabetic retinopathy associated with chronic angle-closure glaucoma. ³⁸	Zhong ZL...Chen S	30809483	2019
10	Cypass Supraciliary Stent in Eye With Chronic Angle Closure and Postvitrectomy With Silicone Oil. ³⁸	Hopen ML...Gallardo MJ	29979341	2018
11	Profile and management outcomes of glaucoma cases at Qassim University Hospital. ³⁸	Alzuhairy S...Mousa A	30202404	2018
12	Angle-closure Glaucoma in a Myopic Patient Precipitated by Sexual Excitation: A Case Report. ³⁸	Popovic M...Schlenker MB	31354207	2018
13	Factors Associated with Outcomes of Combined Phacoemulsification and Ahmed Glaucoma Valve Implantation. ³⁸	Kwon J...Sung KR	29770636	2018
14	Retinal pigment epithelium changes in Kartagener syndrome. ³⁸	Garcia MD...Berrocal AM	29511746	2018
15	Long-term outcomes after acute primary angle closure of Caucasian chronic angle closure glaucoma patients. ³⁸	Fea AM...Aung T	28722309	2018
16	Macular Choroidal Small-Vessel Layer, Sattler's Layer and Haller's Layer Thicknesses: The Beijing Eye Study. ³⁸	Zhao J...Jonas JB	29535365	2018
17	Refractive outcomes of phacoemulsification cataract surgery in glaucoma patients. ³⁸	Manoharan N...Seibold LK	29605284	2018
18	Visual Subfield Progression in Glaucoma Subtypes. ³⁸	Su WW...Chen HS	29750123	2018
19	Longitudinal Change in Peripheral Anterior Chamber Depth of Eyes with Angle Closure after Laser Iridotomy. ³⁸	Furuya T...Kashiwagi K	30671261	2018
20	Optic Nerve Head Characteristics in Chronic Angle Closure Glaucoma Detected by Swept-Source OCT. ³⁸	Li D...Shen LQ	28922031	2017
21	Ocular pulse amplitude in different types of glaucoma using dynamic contour tonometry: Diagnosis and follow-up of glaucoma. ³⁸	Cheng L...Wu Z	29104631	2017
22	Long-term scanning laser ophthalmoscopy and perimetry in different severities of primary open and chronic angle closure glaucoma eyes. ³⁸	Sihota R...Kalaiwani M	29044061	2017
23	Acute hypotony maculopathy following the initiation of a topical aqueous suppressant in a patient with a history of panuveitis without prior filtering surgery. ³⁸	Zhu D...Rao NA	29260088	2017
24	Intraoperative Optical Coherence Tomography-Assisted Descemet Stripping Automated Endothelial Keratoplasty for Anterior Chamber Fibrous Ingrowth. ³⁸	Shazly TA...Espandar L	28399038	2017
25	RETINAL AND CHOROIDAL VASCULAR OCCLUSION FOLLOWING AQUEOUS MISDIRECTION SYNDROME IN A PATIENT WITH SICKLE CELL TRAIT. ³⁸	Dewundara S...Abrams GW	28489705	2017
26	High intensity focused ultrasound as first line treatment in patients with chronic angle closure glaucoma at risk for malignant glaucoma. ³⁸	Graber M...Lachkar Y	28342558	2017
27	Analyzing cytokines as biomarkers to evaluate severity of glaucoma. ³⁸	Tong Y...Wang ZY	28730084	2017
28	Peripapillary retinal splitting visualized on OCT in glaucoma and glaucoma suspect patients. ³⁸	Grewal DS...Tanna AP	28832670	2017
29	Bilateral Same-day Laser Peripheral Iridotomy in the Philadelphia Glaucoma Detection and Treatment Project. ³⁸	Waisbourd M...Katz LJ	26950579	2016
30	Pupillary block due to reverse implantation of a sulcus intraocular lens. ³⁸	Zhang X...Saeedi O	28184333	2016
31	Intraoperative floppy-iris syndrome associated with use of antipsychotic drugs. ³⁸	Matsuo M...Tanito M	27521670	2016
32	Risk Factors of Disease Progression After Cataract Surgery in Chronic Angle-closure Glaucoma Patients. ³⁸	Lee CK...Kim CY	26550967	2016
33	Efficacy and Safety of Trabectome Surgery in Chinese Open-Angle Glaucoma. ³⁸	Lee JW...Lai JS	27082559	2016
34	Endoscopic Cyclophotocoagulation and Pars Plana Ablation (ECP-plus) to Treat Refractory Glaucoma. ³⁸	Tan JC...Chopra V	26020690	2016
35	The Frequency of Optical Coherence Tomography Testing in Glaucoma at a Single Academic Medical Center. ³⁸	Griffith JF...Goldberg JL	26372155	2016
36	The effect of adjustable suture (Khaw) trabeculectomy on intraocular pressure: a retrospective case series. ³⁸	Kaplan A...Dayanir V	26002838	2016
37	Case report: imaging and treatment of ophthalmic manifestations in oculodentodigital dysplasia. ³⁸	Mosaed S...Lin KY	26743931	2016
38	Comparison of phacotrabeculectomy and sequential surgery in the treatment of chronic angle-closure glaucoma coexisted with cataract. ³⁸	Li HJ...Xie L	27275422	2016
39	The safety and efficacy of modified minimally invasive trabeculectomy for the treatment of primary chronic angle-closure glaucoma. ³⁸	Wu Z...Ma D	27215005	2015
40	Rapid anterior capsular phimosis after cataract surgery in a patient with chronic angle closure glaucoma. ³⁸	Chang PY...Chang SW	29018698	2015
41	Transscleral cyclophotocoagulation in refractory acute and chronic angle closure glaucoma. ³⁸	Yusuf IH...James CB	26424819	2015
42	Effect of Goniosynechialysis During Phacoemulsification on IOP in Patients With Medically Well-controlled Chronic Angle-Closure Glaucoma. ³⁸	Lee CK...Kim CY	25387342	2015
43	Diode laser cyclophotocoagulation for nanophthalmic chronic angle closure glaucoma. ³⁸	Golan S...Kurtz S	23807357	2015
44	Prevalence of comorbid retinal disease in patients with glaucoma at an academic medical center. ³⁸	Griffith JF...Goldberg JL	26203217	2015
45	Diffusion tensor imaging of optic nerve and optic radiation in primary chronic angle-closure glaucoma using 3T magnetic resonance imaging. ³⁸	Zhang QJ...Li XH	26558212	2015
46	T-helper1/T-helper2 cytokine imbalance in the iris of patients with glaucoma. ³⁸	Wong M...Zhang C	25811482	2015
47	Meta-analysis of randomized controlled trials comparing latanoprost with other glaucoma medications in chronic angle-closure glaucoma. ³⁸	Li J...Yu M	25044139	2015
48	Delayed diagnosis of subacute angle closure glaucoma in patients presenting with headaches. ³⁸	Nesher R...Segal O	24677021	2014
49	Reduced intraocular pressure after cataract surgery in patients with narrow angles and chronic angle-closure glaucoma. ³⁸	Brown RH...Hovis KL	25134991	2014
50	Effectivity of Nd Yag PI in treatment of acute primary angle closure glaucoma. ³⁸	Singh P...Rijal AP	25799811	2014

Sources

Genes for Chronic Closed-Angle Glaucoma

Genes related to Chronic Closed-Angle Glaucoma (0 elite genes):

(show all 20)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	TGFB2	Transforming Growth Factor Beta 2	Protein Coding	21.72	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵	17908591
2	CTSA	Cathepsin A	Protein Coding	15.72	DISEASES inferred ¹⁵
3	IER3IP1	Immediate Early Response 3 Interacting Protein 1	Protein Coding	15.04	DISEASES inferred ¹⁵
4	AQP7	Aquaporin 7	Protein Coding	14.96	DISEASES inferred ¹⁵
5	AQP3	Aquaporin 3 (Gill Blood Group)	Protein Coding	14.61	DISEASES inferred ¹⁵
6	AQP5	Aquaporin 5	Protein Coding	14.59	DISEASES inferred ¹⁵
7	MYOC	Myocilin	Protein Coding	14.34	DISEASES inferred ¹⁵
8	KIDINS220	Kinase D Interacting Substrate 220	Protein Coding	14.32	DISEASES inferred ¹⁵
9	TGFB3	Transforming Growth Factor Beta 3	Protein Coding	14.29	DISEASES inferred ¹⁵
10	SFRP1	Secreted Frizzled Related Protein 1	Protein Coding	14.26	DISEASES inferred ¹⁵
11	BMP7	Bone Morphogenetic Protein 7	Protein Coding	14.24	DISEASES inferred ¹⁵
12	AQP1	Aquaporin 1 (Colton Blood Group)	Protein Coding	14.19	DISEASES inferred ¹⁵
13	GJA1	Gap Junction Protein Alpha 1	Protein Coding	13.77	DISEASES inferred ¹⁵
14	TNFRSF1A	TNF Receptor Superfamily Member 1A	Protein Coding	13.59	DISEASES inferred ¹⁵
15	AQP4	Aquaporin 4	Protein Coding	13.32	DISEASES inferred ¹⁵
16	CXCL10	C-X-C Motif Chemokine Ligand 10	Protein Coding	13.31	DISEASES inferred ¹⁵
17	TIMP1	TIMP Metallopeptidase Inhibitor 1	Protein Coding	13.21	DISEASES inferred ¹⁵
18	EDN1	Endothelin 1	Protein Coding	13.08	DISEASES inferred ¹⁵
19	PRELID1	PRELI Domain Containing 1	Protein Coding	6.67	DISEASES inferred ¹⁵
20	RNASE2	Ribonuclease A Family Member 2	Protein Coding	4.5	DISEASES inferred ¹⁵

Sources

Variations for Chronic Closed-Angle Glaucoma

Sources

Expression for Chronic Closed-Angle Glaucoma

Search GEO for disease gene expression data for Chronic Closed-Angle Glaucoma.

Sources

Pathways for Chronic Closed-Angle Glaucoma

Pathways related to Chronic Closed-Angle Glaucoma according to GeneCards Suite gene sharing:

(show all 16)

#	Super pathways	Score	Top Affiliating Genes
1	NF-KappaB Family Pathway ⁶⁴ Show member pathways NF-KappaB (p50-p65) Pathway ⁶⁴	12.42	TNFRSF1A TIMP1 TGFB3 TGFB2 BMP7
2	Nanog in Mammalian ESC Pluripotency ⁶⁴ Show member pathways 14-3-3 Induced Intracellular Signaling ⁶⁴ eNOS Signaling ⁶⁴ GSK3 Signaling ⁶⁴	12.37	TNFRSF1A TIMP1 TGFB3 TGFB2 BMP7 AQP7
3	Wnt / Hedgehog / Notch ⁴	11.93	TGFB3 TGFB2 SFRP1 BMP7
4	TNF signaling pathway ³⁷	11.78	TNFRSF1A EDN1 CXCL10
5	Aquaporin-mediated transport ⁶⁶ Show member pathways Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation ²² Glucagon signaling in metabolic regulation ⁶⁶ Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ⁶⁶ Passive transport by Aquaporins ⁶⁶ Transport of glycerol from adipocytes to the liver by Aquaporins ⁶⁶ Vasopressin regulates renal water homeostasis via Aquaporins ⁶⁶	11.77	AQP7 AQP5 AQP4 AQP3 AQP1
6	AGE-RAGE signaling pathway in diabetic complications ³⁷	11.71	TGFB3 TGFB2 EDN1
7	Immune response IFN gamma signaling pathway ²² Show member pathways IFN-gamma pathway ¹	11.67	TNFRSF1A TIMP1 TGFB3 TGFB2 BMP7
8	Angiogenesis (CST) ⁴	11.64	TIMP1 TGFB3 TGFB2
9	TGF-beta signaling pathway (KEGG) ³⁷	11.64	TGFB3 TGFB2 BMP7
10	G-protein signaling_RhoA regulation pathway ²²	11.54	TIMP1 TGFB3 TGFB2 BMP7
11	Spinal Cord Injury ¹	11.54	GJA1 CXCL10 AQP4 AQP1
12	Elastic fibre formation ⁶⁶ Show member pathways Molecules associated with elastic fibres ⁶⁶	11.52	TGFB3 TGFB2 BMP7
13	Microglia Activation During Neuroinflammation: Microglia Polarization ⁶⁵	11.48	TGFB3 TGFB2 CXCL10
14	Lung fibrosis ¹	11.41	TIMP1 EDN1 BMP7
15	Interleukin-10 signaling ⁶⁶	11.19	TNFRSF1A TIMP1 CXCL10
16	G-protein signaling_Rap2B regulation pathway ²²	10.83	TIMP1 TGFB3 TGFB2 CXCL10 BMP7

Sources

GO Terms for Chronic Closed-Angle Glaucoma

Cellular components related to Chronic Closed-Angle Glaucoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	9.61	TNFRSF1A TIMP1 TGFB3 TGFB2 SFRP1 MYOC
2	collagen-containing extracellular matrix	GO:0062023	9.56	TGFB3 TGFB2 SFRP1 BMP7
3	extracellular region	GO:0005576	9.36	TNFRSF1A TIMP1 TGFB3 TGFB2 SFRP1 RNASE2
4	platelet alpha granule lumen	GO:0031093	9.33	TIMP1 TGFB3 TGFB2

Biological processes related to Chronic Closed-Angle Glaucoma according to GeneCards Suite gene sharing:

(show all 38)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of cell proliferation	GO:0008284	9.99	TIMP1 TGFB3 TGFB2 SFRP1 EDN1 CXCL10
2	response to drug	GO:0042493	9.97	TGFB2 SFRP1 EDN1 AQP1
3	regulation of apoptotic process	GO:0042981	9.96	TGFB3 TGFB2 PRELID1 BMP7
4	negative regulation of gene expression	GO:0010629	9.95	TGFB2 SFRP1 GJA1 EDN1
5	in utero embryonic development	GO:0001701	9.92	TGFB3 KIDINS220 GJA1 EDN1
6	platelet degranulation	GO:0002576	9.85	TIMP1 TGFB3 TGFB2
7	negative regulation of cell growth	GO:0030308	9.85	TGFB2 SFRP1 GJA1
8	osteoblast differentiation	GO:0001649	9.84	SFRP1 MYOC GJA1
9	wound healing	GO:0042060	9.84	TIMP1 TGFB3 TGFB2
10	neutrophil chemotaxis	GO:0030593	9.82	TGFB2 EDN1 CXCL10
11	cellular response to mechanical stimulus	GO:0071260	9.82	TNFRSF1A GJA1 AQP1
12	cell-cell signaling	GO:0007267	9.81	GJA1 EDN1 CXCL10
13	cartilage development	GO:0051216	9.81	TIMP1 EDN1 BMP7
14	cell development	GO:0048468	9.77	TGFB3 TGFB2 BMP7
15	SMAD protein signal transduction	GO:0060395	9.77	TGFB3 TGFB2 BMP7
16	response to peptide hormone	GO:0043434	9.76	TIMP1 GJA1 BMP7
17	positive regulation of stress fiber assembly	GO:0051496	9.75	TGFB3 SFRP1 MYOC
18	positive regulation of pathway-restricted SMAD protein phosphorylation	GO:0010862	9.74	TGFB3 TGFB2 BMP7
19	positive regulation of epithelial to mesenchymal transition	GO:0010718	9.72	TGFB3 TGFB2 BMP7
20	regulation of MAPK cascade	GO:0043408	9.67	TGFB3 TGFB2 MYOC BMP7
21	secondary palate development	GO:0062009	9.66	TGFB3 TGFB2
22	renal water homeostasis	GO:0003091	9.65	AQP4 AQP3 AQP1
23	cellular response to hypoxia	GO:0071456	9.65	SFRP1 EDN1 BMP7 AQP3 AQP1
24	multicellular organismal water homeostasis	GO:0050891	9.63	AQP4 AQP1
25	regulation of branching involved in prostate gland morphogenesis	GO:0060687	9.61	SFRP1 BMP7
26	pancreatic juice secretion	GO:0030157	9.61	AQP5 AQP1
27	cell-cell junction organization	GO:0045216	9.61	TGFB3 TGFB2 GJA1
28	response to vitamin D	GO:0033280	9.58	CXCL10 BMP7 AQP3
29	negative regulation of macrophage cytokine production	GO:0010936	9.56	TGFB3 TGFB2
30	carbon dioxide transport	GO:0015670	9.54	AQP5 AQP1
31	salivary gland morphogenesis	GO:0007435	9.5	TGFB3 TGFB2 BMP7
32	nitric oxide transport	GO:0030185	9.49	EDN1 AQP1
33	uterine wall breakdown	GO:0042704	9.46	TGFB3 TGFB2
34	odontogenesis	GO:0042476	9.35	TGFB3 TGFB2 AQP5 AQP3 AQP1
35	glycerol transport	GO:0015793	9.33	AQP7 AQP3 AQP1
36	water transport	GO:0006833	9.02	AQP7 AQP5 AQP4 AQP3 AQP1
37	negative regulation of cell proliferation	GO:0008285	10.02	TGFB3 TGFB2 SFRP1 GJA1 BMP7
38	transmembrane transport	GO:0055085	10	GJA1 AQP7 AQP5 AQP4 AQP3 AQP1

Molecular functions related to Chronic Closed-Angle Glaucoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	growth factor activity	GO:0008083	9.71	TIMP1 TGFB3 TGFB2 BMP7
2	cytokine activity	GO:0005125	9.63	TIMP1 TGFB3 TGFB2 EDN1 CXCL10 BMP7
3	transforming growth factor beta receptor binding	GO:0005160	9.54	TGFB3 TGFB2 BMP7
4	type II transforming growth factor beta receptor binding	GO:0005114	9.46	TGFB3 TGFB2
5	channel activity	GO:0015267	9.35	AQP7 AQP5 AQP4 AQP3 AQP1
6	glycerol channel activity	GO:0015254	9.32	AQP7 AQP3
7	type III transforming growth factor beta receptor binding	GO:0034714	9.26	TGFB3 TGFB2
8	water transmembrane transporter activity	GO:0005372	9.13	AQP1
9	water channel activity	GO:0015250	9.02	AQP7 AQP5 AQP4 AQP3 AQP1

Sources

Sources for Chronic Closed-Angle Glaucoma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ TGDB

⁷¹ Tocris

⁷² UMLS

⁷³ UMLS via Orphanet

⁷⁴ UniProtKB/Swiss-Prot

⁷⁵ Wikipedia

Chronic Closed-Angle Glaucoma

Aliases & Classifications for Chronic Closed-Angle Glaucoma

MalaCards integrated aliases for Chronic Closed-Angle Glaucoma:

Classifications:

External Ids:

Summaries for Chronic Closed-Angle Glaucoma

Related Diseases for Chronic Closed-Angle Glaucoma

Diseases in the Acute Closed-Angle Glaucoma family:

Diseases related to Chronic Closed-Angle Glaucoma via text searches within MalaCards or GeneCards Suite gene sharing:

Comorbidity relations with Chronic Closed-Angle Glaucoma via Phenotypic Disease Network (PDN):

Graphical network of the top 20 diseases related to Chronic Closed-Angle Glaucoma:

Symptoms & Phenotypes for Chronic Closed-Angle Glaucoma

MGI Mouse Phenotypes related to Chronic Closed-Angle Glaucoma:

Drugs & Therapeutics for Chronic Closed-Angle Glaucoma

Drugs for Chronic Closed-Angle Glaucoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Inferred drug relations via UMLS 72 / NDF-RT 51 :

Genetic Tests for Chronic Closed-Angle Glaucoma

Anatomical Context for Chronic Closed-Angle Glaucoma

MalaCards organs/tissues related to Chronic Closed-Angle Glaucoma:

Publications for Chronic Closed-Angle Glaucoma

Articles related to Chronic Closed-Angle Glaucoma:

Genes for Chronic Closed-Angle Glaucoma

Genes related to Chronic Closed-Angle Glaucoma (0 elite genes):

Variations for Chronic Closed-Angle Glaucoma

Expression for Chronic Closed-Angle Glaucoma

Pathways for Chronic Closed-Angle Glaucoma

Pathways related to Chronic Closed-Angle Glaucoma according to GeneCards Suite gene sharing:

GO Terms for Chronic Closed-Angle Glaucoma

Cellular components related to Chronic Closed-Angle Glaucoma according to GeneCards Suite gene sharing:

Biological processes related to Chronic Closed-Angle Glaucoma according to GeneCards Suite gene sharing:

Molecular functions related to Chronic Closed-Angle Glaucoma according to GeneCards Suite gene sharing:

Sources for Chronic Closed-Angle Glaucoma

Inferred drug relations via UMLS ⁷² / NDF-RT ⁵¹ :