MCID: CHR054
MIFTS: 32

Chronic Closed-Angle Glaucoma

Categories: Eye diseases

Aliases & Classifications for Chronic Closed-Angle Glaucoma

MalaCards integrated aliases for Chronic Closed-Angle Glaucoma:

Name: Chronic Closed-Angle Glaucoma 12 15
Anatomical Narrow Angle Glaucoma 12 71
Chronic Angle-Closure Glaucoma 12 54
Secondary Angle-Closure Glaucoma - Synechial 71
Chronic Narrow Angle Glaucoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:14445
ICD9CM 34 365.23
SNOMED-CT 67 15417005 33647009
ICD10 32 H40.22
UMLS 71 C0154947 C1272657

Summaries for Chronic Closed-Angle Glaucoma

MalaCards based summary : Chronic Closed-Angle Glaucoma, also known as anatomical narrow angle glaucoma, is related to open-angle glaucoma and acute closed-angle glaucoma. An important gene associated with Chronic Closed-Angle Glaucoma is TGFB2 (Transforming Growth Factor Beta 2), and among its related pathways/superpathways is ECM proteoglycans. The drugs Pilocarpine and Latanoprost have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and endothelial.

Related Diseases for Chronic Closed-Angle Glaucoma

Diseases in the Acute Closed-Angle Glaucoma family:

Chronic Closed-Angle Glaucoma

Diseases related to Chronic Closed-Angle Glaucoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 44)
# Related Disease Score Top Affiliating Genes
1 open-angle glaucoma 30.6 TGFB2 MYOC LOXL1
2 acute closed-angle glaucoma 30.6 MYOC LAMA3 CTSA
3 glaucoma, primary open angle 30.6 TGFB2 MYOC LOXL1
4 intraocular pressure quantitative trait locus 30.2 TGFB2 MYOC LOXL1 CTSA
5 corneal edema 30.2 MYOC LAMA3
6 ocular hypertension 29.9 TGFB2 MYOC
7 cataract 10.7
8 primary angle-closure glaucoma 10.5
9 optic nerve disease 10.5
10 myopia 10.3
11 weill-marchesani syndrome 10.3
12 microphthalmia 10.3
13 neovascular glaucoma 10.2 TGFB2 NARF
14 glaucoma-related pigment dispersion syndrome 10.2 MYOC LOXL1
15 juvenile glaucoma 10.1 MYOC LOXL1
16 retinal detachment 10.1
17 retinitis pigmentosa 10.1
18 yemenite deaf-blind hypopigmentation syndrome 10.1
19 microvascular complications of diabetes 5 10.1
20 weill-marchesani syndrome 4 10.1
21 microcephaly, epilepsy, and diabetes syndrome 10.1
22 spastic paraplegia, intellectual disability, nystagmus, and obesity 10.1
23 exudative vitreoretinopathy 10.1
24 brachydactyly 10.1
25 neuroretinitis 10.1
26 lens subluxation 10.1
27 uveitis 10.1
28 retinal vein occlusion 10.1
29 central retinal vein occlusion 10.1
30 phimosis 10.1
31 retinitis 10.1
32 macular retinal edema 10.1
33 eye disease 10.1
34 scotoma 10.1
35 iridocyclitis 10.1
36 refractive error 10.1
37 vitreoretinopathy 10.1
38 iris disease 10.0 MYOC LOXL1
39 phacogenic glaucoma 10.0 NARF MYOC LOXL1
40 primary congenital glaucoma 10.0 MYOC LOXL1
41 aqueous misdirection 9.9 NARF LAMA3 CTSA
42 glaucoma, normal tension 9.9 MYOC LOXL1
43 lens disease 9.9 MYOC LOXL1 LAMA3
44 oculodentodigital dysplasia 9.9 PANX3 PANX2

Comorbidity relations with Chronic Closed-Angle Glaucoma via Phenotypic Disease Network (PDN):


Glaucoma, Primary Open Angle Hypertension, Essential

Graphical network of the top 20 diseases related to Chronic Closed-Angle Glaucoma:



Diseases related to Chronic Closed-Angle Glaucoma

Symptoms & Phenotypes for Chronic Closed-Angle Glaucoma

Drugs & Therapeutics for Chronic Closed-Angle Glaucoma

Drugs for Chronic Closed-Angle Glaucoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pilocarpine Approved, Investigational Phase 4 92-13-7, 54-71-7 5910
2
Latanoprost Approved, Investigational Phase 4 130209-82-4 5282380 5311221
3
Travoprost Approved Phase 4 157283-68-6 5282226
4
Timolol Approved Phase 4 26839-75-8 33624 5478
5
Brinzolamide Approved Phase 4 138890-62-7 68844
6
Maleic acid Experimental, Investigational Phase 4 110-17-8, 110-16-7 444972
7 Autonomic Agents Phase 4
8 Muscarinic Agonists Phase 4
9 Cholinergic Agents Phase 4
10 Antihypertensive Agents Phase 4
11 Pharmaceutical Solutions Phase 4
12 Ophthalmic Solutions Phase 4
13 Neurotransmitter Agents Phase 4
14 Anti-Arrhythmia Agents Phase 4
15 Adrenergic Agonists Phase 4
16 Adrenergic Antagonists Phase 4
17 Adrenergic alpha-2 Receptor Agonists Phase 4
18 Adrenergic beta-Antagonists Phase 4
19 Brimonidine Tartrate, Timolol Maleate Drug Combination Phase 4
20 Brimonidine Tartrate Phase 4 70359-46-5
21 Adrenergic Agents Phase 4
22 Carbonic Anhydrase Inhibitors Phase 4
23
Bimatoprost Approved, Investigational 155206-00-1 5311027

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 A Twelve-Week, Double Masked, Parallel Group, Primary-Therapy Pilot Study of the Safety and Efficacy of Travoprost 0.004% Compared to Pilocarpine 1% in Patients With Chronic Angle-Closure Glaucoma Completed NCT00762645 Phase 4 Travoprost 0.004% (Travatan);Pilocarpine 1%
2 An 8 Week, Single Masked, Parallel-Group, Exploratory Study Comparing Ocular Surface Signs and Symptoms in Monotherapy Ocular Hypertension or Glaucoma Patients Randomized to Either Xalatan® or Travatan Z® Completed NCT00799682 Phase 4 Xalatan;Travatan Z
3 Study of Brimonidine and Timolol Ophthalmic Solution With Latanoprost Compared With Latanoprost in Glaucoma Patients Terminated NCT01151904 Phase 4 brimonidine 0.2%/timolol 0.5% fixed combination ophthalmic solution;latanoprost
4 A Double-Masked, Parallel-Group, Efficacy and Safety Study of Brinzolamide 1.0% (AZOPT) as Adjunctive Therapy to Travoprost 0.004% (TRAVATAN) in Patients With Chronic Angle-Closure Glaucoma Terminated NCT00758342 Phase 4 Travoprost 0.004% + Brinzolamide 1.0%;Travoprost 0.004% + Tears Natural
5 A Safety and Efficacy Study of Travoprost 0.004% Compared to Latanoprost 0.005% in Patients With Chronic Angle-Closure Glaucoma. Completed NCT00051181 Phase 3 Travoprost (0.004%);Latanoprost (0.005%)
6 A Prospective Study to Assess the Hypotensive Efficacy of Rho-Kinase Inhibitor AR-12286 Ophthalmic Solution 0.5% and 0.7% in Patients With Chronic Angle-closure Glaucoma Unknown status NCT02152774 Phase 2 Rho-Kinase Inhibitor
7 Prevalence of Chronic Angle Closure in Caucasian Hyperopic Subjects Unknown status NCT00823706
8 Comparison of Bimatoprost and Lataprost in Patients With Chronic Angle-Closure Glaucoma: A Randomized Cross-Over Study Unknown status NCT00567788 Latanoprost-Bimatoprost;Bimatoporost-Latanoprost
9 Biometric Indicators of Eyes With Occult Lens Subluxation Completed NCT03752710
10 Angle Closure: Laser Iridotomy Versus Phacoemulsification Study (ACLIPS)- A Study of Acute Primary Angle Closure Glaucoma Comparing Two Treatment Modalities: Laser Peripheral vs Phacoemulsification With Posterior Intraocular Lens Implant Completed NCT00350428
11 Comparison Study of Glaucoma Eye Care Follow-Up Adherence in a High Risk Population Completed NCT02347670
12 Sequential Laser Iridotomy Using Argon and Q-Switched 532 nm Frequency Doubled Neodymium Yag Laser: A Pilot Study Completed NCT00452998

Search NIH Clinical Center for Chronic Closed-Angle Glaucoma

Genetic Tests for Chronic Closed-Angle Glaucoma

Anatomical Context for Chronic Closed-Angle Glaucoma

MalaCards organs/tissues related to Chronic Closed-Angle Glaucoma:

40
Eye, Testes, Endothelial

Publications for Chronic Closed-Angle Glaucoma

Articles related to Chronic Closed-Angle Glaucoma:

(show top 50) (show all 320)
# Title Authors PMID Year
1
A phase III study of subconjunctival human anti-transforming growth factor beta(2) monoclonal antibody (CAT-152) to prevent scarring after first-time trabeculectomy. 54 61
17908591 2007
2
Aqueous humor levels of TGFβ2 and SFRP1 in different types of glaucoma. 61
31382918 2019
3
Differential Efficacy of Combined Phacoemulsification and Endocyclophotocoagulation in Open-angle Glaucoma Versus Angle-closure Glaucoma. 61
30839415 2019
4
Anterior Segment Features in Nanophthalmos With Secondary Chronic Angle Closure Glaucoma: An Ultrasound Biomicroscopy Study. 61
31112609 2019
5
Early results of micropulse transscleral cyclophotocoagulation for the treatment of glaucoma. 61
30938190 2019
6
Surgical outcomes of phacoemulsification/goniosynechialysis with and without endocyclophotocoagulation in patients with chronic angle closure glaucoma. 61
30777954 2019
7
Primary Outcomes of Patients with Chronic Angle-Closure Glaucoma Treated with Combined Phacoemulsification, Viscogoniosynechialysis, and Endocyclophotocoagulation. 61
31312531 2019
8
Post-miosis changes in the anterior chamber structures in primary and lens-induced secondary chronic angle-closure glaucoma. 61
31024825 2019
9
Indicating and predicting role of the horizontal C/D ratio in preclinical diabetic retinopathy associated with chronic angle-closure glaucoma. 61
30809483 2019
10
RETINAL AND CHOROIDAL VASCULAR OCCLUSION FOLLOWING AQUEOUS MISDIRECTION SYNDROME IN A PATIENT WITH SICKLE CELL TRAIT. 61
28489705 2019
11
Cypass Supraciliary Stent in Eye With Chronic Angle Closure and Postvitrectomy With Silicone Oil. 61
29979341 2018
12
Profile and management outcomes of glaucoma cases at Qassim University Hospital. 61
30202404 2018
13
Angle-closure Glaucoma in a Myopic Patient Precipitated by Sexual Excitation: A Case Report. 61
31354207 2018
14
Factors Associated with Outcomes of Combined Phacoemulsification and Ahmed Glaucoma Valve Implantation. 61
29770636 2018
15
Retinal pigment epithelium changes in Kartagener syndrome. 61
29511746 2018
16
Long-term outcomes after acute primary angle closure of Caucasian chronic angle closure glaucoma patients. 61
28722309 2018
17
Macular Choroidal Small-Vessel Layer, Sattler's Layer and Haller's Layer Thicknesses: The Beijing Eye Study. 61
29535365 2018
18
Refractive outcomes of phacoemulsification cataract surgery in glaucoma patients. 61
29605284 2018
19
Visual Subfield Progression in Glaucoma Subtypes. 61
29750123 2018
20
Longitudinal Change in Peripheral Anterior Chamber Depth of Eyes with Angle Closure after Laser Iridotomy. 61
30671261 2018
21
Ocular pulse amplitude in different types of glaucoma using dynamic contour tonometry: Diagnosis and follow-up of glaucoma. 61
29104631 2017
22
Optic Nerve Head Characteristics in Chronic Angle Closure Glaucoma Detected by Swept-Source OCT. 61
28922031 2017
23
Long-term scanning laser ophthalmoscopy and perimetry in different severities of primary open and chronic angle closure glaucoma eyes. 61
29044061 2017
24
Acute hypotony maculopathy following the initiation of a topical aqueous suppressant in a patient with a history of panuveitis without prior filtering surgery. 61
29260088 2017
25
Intraoperative Optical Coherence Tomography-Assisted Descemet Stripping Automated Endothelial Keratoplasty for Anterior Chamber Fibrous Ingrowth. 61
28399038 2017
26
High intensity focused ultrasound as first line treatment in patients with chronic angle closure glaucoma at risk for malignant glaucoma. 61
28342558 2017
27
Analyzing cytokines as biomarkers to evaluate severity of glaucoma. 61
28730084 2017
28
Peripapillary retinal splitting visualized on OCT in glaucoma and glaucoma suspect patients. 61
28832670 2017
29
Bilateral Same-day Laser Peripheral Iridotomy in the Philadelphia Glaucoma Detection and Treatment Project. 61
26950579 2016
30
Pupillary block due to reverse implantation of a sulcus intraocular lens. 61
28184333 2016
31
Intraoperative floppy-iris syndrome associated with use of antipsychotic drugs. 61
27521670 2016
32
Risk Factors of Disease Progression After Cataract Surgery in Chronic Angle-closure Glaucoma Patients. 61
26550967 2016
33
Efficacy and Safety of Trabectome Surgery in Chinese Open-Angle Glaucoma. 61
27082559 2016
34
Endoscopic Cyclophotocoagulation and Pars Plana Ablation (ECP-plus) to Treat Refractory Glaucoma. 61
26020690 2016
35
The Frequency of Optical Coherence Tomography Testing in Glaucoma at a Single Academic Medical Center. 61
26372155 2016
36
The effect of adjustable suture (Khaw) trabeculectomy on intraocular pressure: a retrospective case series. 61
26002838 2016
37
Case report: imaging and treatment of ophthalmic manifestations in oculodentodigital dysplasia. 61
26743931 2016
38
Comparison of phacotrabeculectomy and sequential surgery in the treatment of chronic angle-closure glaucoma coexisted with cataract. 61
27275422 2016
39
The safety and efficacy of modified minimally invasive trabeculectomy for the treatment of primary chronic angle-closure glaucoma. 61
27215005 2015
40
Rapid anterior capsular phimosis after cataract surgery in a patient with chronic angle closure glaucoma. 61
29018698 2015
41
Transscleral cyclophotocoagulation in refractory acute and chronic angle closure glaucoma. 61
26424819 2015
42
Effect of Goniosynechialysis During Phacoemulsification on IOP in Patients With Medically Well-controlled Chronic Angle-Closure Glaucoma. 61
25387342 2015
43
Diode laser cyclophotocoagulation for nanophthalmic chronic angle closure glaucoma. 61
23807357 2015
44
Prevalence of comorbid retinal disease in patients with glaucoma at an academic medical center. 61
26203217 2015
45
Diffusion tensor imaging of optic nerve and optic radiation in primary chronic angle-closure glaucoma using 3T magnetic resonance imaging. 61
26558212 2015
46
Meta-analysis of randomized controlled trials comparing latanoprost with other glaucoma medications in chronic angle-closure glaucoma. 61
25044139 2015
47
T-helper1/T-helper2 cytokine imbalance in the iris of patients with glaucoma. 61
25811482 2015
48
Delayed diagnosis of subacute angle closure glaucoma in patients presenting with headaches. 61
24677021 2014
49
Reduced intraocular pressure after cataract surgery in patients with narrow angles and chronic angle-closure glaucoma. 61
25134991 2014
50
Effectivity of Nd Yag PI in treatment of acute primary angle closure glaucoma. 61
25799811 2014

Variations for Chronic Closed-Angle Glaucoma

Expression for Chronic Closed-Angle Glaucoma

Search GEO for disease gene expression data for Chronic Closed-Angle Glaucoma.

Pathways for Chronic Closed-Angle Glaucoma

Pathways related to Chronic Closed-Angle Glaucoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.38 TGFB2 LAMA3

GO Terms for Chronic Closed-Angle Glaucoma

Cellular components related to Chronic Closed-Angle Glaucoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 gap junction GO:0005921 8.96 PANX3 PANX2
2 collagen-containing extracellular matrix GO:0062023 8.92 TGFB2 MYOC LOXL1 LAMA3

Biological processes related to Chronic Closed-Angle Glaucoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein hexamerization GO:0034214 8.96 PANX3 PANX2
2 positive regulation of interleukin-1 secretion GO:0050716 8.62 PANX3 PANX2

Molecular functions related to Chronic Closed-Angle Glaucoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 channel activity GO:0015267 9.16 PANX3 PANX2
2 gap junction hemi-channel activity GO:0055077 8.96 PANX3 PANX2
3 wide pore channel activity GO:0022829 8.62 PANX3 PANX2

Sources for Chronic Closed-Angle Glaucoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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