MCID: CHR054
MIFTS: 41

Chronic Closed-Angle Glaucoma

Categories: Eye diseases

Aliases & Classifications for Chronic Closed-Angle Glaucoma

MalaCards integrated aliases for Chronic Closed-Angle Glaucoma:

Name: Chronic Closed-Angle Glaucoma 12 15
Anatomical Narrow Angle Glaucoma 12 74
Chronic Angle-Closure Glaucoma 12 56
Secondary Angle-Closure Glaucoma - Synechial 74
Chronic Narrow Angle Glaucoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:14445
ICD9CM 36 365.23
SNOMED-CT 69 15417005 33647009
ICD10 34 H40.22

Summaries for Chronic Closed-Angle Glaucoma

MalaCards based summary : Chronic Closed-Angle Glaucoma, also known as anatomical narrow angle glaucoma, is related to glaucoma, primary open angle and low tension glaucoma. An important gene associated with Chronic Closed-Angle Glaucoma is TGFB2 (Transforming Growth Factor Beta 2), and among its related pathways/superpathways are NF-KappaB Family Pathway and Nanog in Mammalian ESC Pluripotency. The drugs Latanoprost and Pilocarpine have been mentioned in the context of this disorder. Affiliated tissues include eye, and related phenotypes are no effect and cardiovascular system

Related Diseases for Chronic Closed-Angle Glaucoma

Diseases in the Acute Closed-Angle Glaucoma family:

Chronic Closed-Angle Glaucoma

Diseases related to Chronic Closed-Angle Glaucoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 29)
# Related Disease Score Top Affiliating Genes
1 glaucoma, primary open angle 30.6 MYOC PHEX TGFB2
2 low tension glaucoma 30.3 EDN1 MYOC PHEX
3 cataract 10.4
4 weill-marchesani syndrome 10.2
5 open-angle glaucoma 10.2
6 multilocular clear cell renal cell carcinoma 10.2 TGFB2 TGFB3
7 juvenile glaucoma 10.2 MYOC PHEX TGFB2
8 hydrarthrosis 10.2 AQP1 AQP3 AQP7
9 chronic gonococcal salpingitis 10.1 CTSA TNFRSF1A
10 retinitis pigmentosa 10.1
11 leber congenital amaurosis 4 10.1
12 microvascular complications of diabetes 5 10.1
13 retinal vein occlusion 10.1
14 exudative vitreoretinopathy 10.1
15 acute closed-angle glaucoma 10.1
16 central retinal vein occlusion 10.1
17 phimosis 10.1
18 retinitis 10.1
19 diabetes insipidus, nephrogenic, autosomal 10.0 AQP1 AQP3 AQP4
20 loeys-dietz syndrome 4 10.0 TGFB2 TGFB3
21 diffuse pulmonary fibrosis 10.0 AQP5 BMP7 TIMP1
22 central pontine myelinolysis 10.0 AQP1 AQP4
23 oligohydramnios 9.9 AQP1 AQP3 EDN1
24 meniere disease 9.8 AQP1 AQP3 AQP4 AQP5 AQP7
25 optic nerve disease 9.8 AQP4 EDN1 MYOC
26 demyelinating disease 9.8 AQP4 CXCL10 TNFRSF1A
27 microvascular complications of diabetes 1 9.8 EDN1 TGFB2 TIMP1
28 tendinosis 9.7 CXCL10 TGFB2 TIMP1 TNFRSF1A
29 nephrogenic systemic fibrosis 9.5 EDN1 EPO TIMP1

Comorbidity relations with Chronic Closed-Angle Glaucoma via Phenotypic Disease Network (PDN):


Glaucoma, Primary Open Angle Hypertension, Essential

Graphical network of the top 20 diseases related to Chronic Closed-Angle Glaucoma:



Diseases related to Chronic Closed-Angle Glaucoma

Symptoms & Phenotypes for Chronic Closed-Angle Glaucoma

GenomeRNAi Phenotypes related to Chronic Closed-Angle Glaucoma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 9.92 ABCC6 AQP1 AQP3 AQP4 AQP5 AQP7

MGI Mouse Phenotypes related to Chronic Closed-Angle Glaucoma:

47 (show all 17)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.43 ABCC6 AQP1 AQP3 AQP4 BMP7 CTSA
2 growth/size/body region MP:0005378 10.36 AQP1 AQP3 AQP4 AQP5 AQP7 BMP7
3 homeostasis/metabolism MP:0005376 10.36 ABCC6 AQP1 AQP3 AQP4 AQP5 AQP7
4 behavior/neurological MP:0005386 10.27 AQP1 AQP3 AQP4 AQP5 BMP7 CTSA
5 endocrine/exocrine gland MP:0005379 10.26 AQP1 AQP4 AQP5 AQP7 BMP7 EDN1
6 hematopoietic system MP:0005397 10.26 AQP1 AQP4 BMP7 CTSA CXCL10 EPO
7 mortality/aging MP:0010768 10.24 AQP1 AQP3 AQP4 AQP5 BMP7 CTSA
8 immune system MP:0005387 10.21 AQP3 AQP4 BMP7 CTSA CXCL10 EPO
9 craniofacial MP:0005382 10.2 AQP3 BMP7 CTSA EDN1 GJA1 PHEX
10 digestive/alimentary MP:0005381 10.19 AQP3 AQP4 AQP5 BMP7 EDN1 PHEX
11 hearing/vestibular/ear MP:0005377 10.15 AQP1 AQP3 AQP4 AQP5 BMP7 EDN1
12 nervous system MP:0003631 10.02 AQP1 AQP4 BMP7 CXCL10 EDN1 GJA1
13 limbs/digits/tail MP:0005371 10.01 BMP7 EPO GJA1 PHEX TGFB2 TGFB3
14 renal/urinary system MP:0005367 10 ABCC6 AQP1 AQP3 AQP4 AQP7 BMP7
15 respiratory system MP:0005388 9.93 AQP1 AQP3 AQP4 AQP5 BMP7 CTSA
16 skeleton MP:0005390 9.7 AQP1 AQP3 BMP7 EDN1 EPO GJA1
17 vision/eye MP:0005391 9.36 ABCC6 AQP1 AQP3 AQP4 AQP5 BMP7

Drugs & Therapeutics for Chronic Closed-Angle Glaucoma

Drugs for Chronic Closed-Angle Glaucoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Latanoprost Approved, Investigational Phase 4,Phase 3,Not Applicable 130209-82-4 5311221 5282380
2
Pilocarpine Approved, Investigational Phase 4 54-71-7, 92-13-7 5910
3
Travoprost Approved Phase 4,Phase 3 157283-68-6 5282226
4
Brinzolamide Approved Phase 4 138890-62-7 68844
5
Timolol Approved Phase 4 26839-75-8 5478 33624
6
Maleic acid Experimental, Investigational Phase 4 110-17-8, 110-16-7 444972
7 Antihypertensive Agents Phase 4,Phase 3,Phase 2,Not Applicable
8 Ophthalmic Solutions Phase 4,Phase 2
9 Pharmaceutical Solutions Phase 4,Phase 2
10 Muscarinic Agonists Phase 4
11 Neurotransmitter Agents Phase 4
12 Autonomic Agents Phase 4
13 Peripheral Nervous System Agents Phase 4
14 Cholinergic Agents Phase 4
15 Carbonic Anhydrase Inhibitors Phase 4
16 Adrenergic Agonists Phase 4
17 Adrenergic alpha-Agonists Phase 4
18 Adrenergic beta-Antagonists Phase 4
19 Adrenergic Antagonists Phase 4
20 Adrenergic Agents Phase 4
21 Brimonidine Tartrate Phase 4 70359-46-5
22 Brimonidine Tartrate, Timolol Maleate Drug Combination Phase 4
23 Anti-Arrhythmia Agents Phase 4
24 Adrenergic alpha-2 Receptor Agonists Phase 4
25
Bimatoprost Approved, Investigational Not Applicable 155206-00-1 5311027

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Travoprost 0.004% Versus Pilocarpine 1% in Patients With Chronic Angle Closure Glaucoma (CACG) Completed NCT00762645 Phase 4 Travoprost 0.004% (Travatan);Pilocarpine 1%
2 Exploratory Study Comparing Signs and Symptoms in Patients With Ocular Hypertension or Glaucoma Using Xalatan R® or Travatan Z® Completed NCT00799682 Phase 4 Xalatan;Travatan Z
3 Azopt (Brinzolamide 1.0%) Plus Travatan (Travoprost 0.004%) in Treating Patients With Chronic Angle-Closure Glaucoma (CACG) Terminated NCT00758342 Phase 4 Travoprost 0.004% + Brinzolamide 1.0%;Travoprost 0.004% + Tears Natural
4 Study of Brimonidine and Timolol Ophthalmic Solution With Latanoprost Compared With Latanoprost in Glaucoma Patients Terminated NCT01151904 Phase 4 brimonidine 0.2%/timolol 0.5% fixed combination ophthalmic solution;latanoprost
5 A Safety and Efficacy Study of Travoprost 0.004% Compared to Latanoprost 0.005% in Patients With Chronic Angle-Closure Glaucoma Completed NCT00051181 Phase 3 Travoprost (0.004%);Latanoprost (0.005%)
6 A Study to Assess the Effect of Rho-Kinase Inhibitor AR-12286 Ophthalmic Solution 0.5% and 0.7% in Patients With Chronic Angle-closure Glaucoma Unknown status NCT02152774 Phase 2 Rho-Kinase Inhibitor
7 Comparison of Bimatoprost and Latanoprost in Patients With Chronic Angle-Closure Glaucoma: A Randomized Cross-Over Study Unknown status NCT00567788 Not Applicable Latanoprost-Bimatoprost;Bimatoporost-Latanoprost
8 Prevalence of Angle Closure in Caucasian Hyperopes Unknown status NCT00823706
9 Biometry of Occult Lens Subluxation Misdiagnosed as Primary Acute Angle Closed Glaucoma Completed NCT03752710
10 Sequential Laser Iridotomy Using Argon and Q-Switched 532 nm Frequency Doubled Neodymium Yag Laser: A Pilot Study Completed NCT00452998 Not Applicable
11 Advanced Glaucoma Progression Study Active, not recruiting NCT01742819

Search NIH Clinical Center for Chronic Closed-Angle Glaucoma

Genetic Tests for Chronic Closed-Angle Glaucoma

Anatomical Context for Chronic Closed-Angle Glaucoma

MalaCards organs/tissues related to Chronic Closed-Angle Glaucoma:

42
Eye

Publications for Chronic Closed-Angle Glaucoma

Articles related to Chronic Closed-Angle Glaucoma:

(show all 19)
# Title Authors Year
1
Indicating and predicting role of the horizontal C/D ratio in preclinical diabetic retinopathy associated with chronic angle-closure glaucoma. ( 30809483 )
2019
2
Comparison of phacotrabeculectomy and sequential surgery in the treatment of chronic angle-closure glaucoma coexisted with cataract. ( 27275422 )
2016
3
Risk Factors of Disease Progression After Cataract Surgery in Chronic Angle-closure Glaucoma Patients. ( 26550967 )
2016
4
Rapid anterior capsular phimosis after cataract surgery in a patient with chronic angle closure glaucoma. ( 29018698 )
2015
5
Diode laser cyclophotocoagulation for nanophthalmic chronic angle closure glaucoma. ( 23807357 )
2015
6
The safety and efficacy of modified minimally invasive trabeculectomy for the treatment of primary chronic angle-closure glaucoma. ( 27215005 )
2015
7
Interocular asymmetry of the visual field defects in newly diagnosed normal-tension glaucoma, primary open-angle glaucoma, and chronic angle-closure glaucoma. ( 23632403 )
2014
8
Phacoemulsification versus trabeculectomy in medically uncontrolled chronic angle-closure glaucoma without cataract. ( 23823520 )
2013
9
Patterns of damage in chronic angle-closure glaucoma compared to primary open-angle glaucoma. ( 21470591 )
2011
10
Weill Marchesani syndrome with chronic angle closure glaucoma in Ethiopia: a case report. ( 19743786 )
2009
11
Optic nerve head morphologic characteristics in chronic angle-closure glaucoma and normal-tension glaucoma. ( 19680054 )
2009
12
Phacoemulsification versus combined phacotrabeculectomy in medically uncontrolled chronic angle closure glaucoma with cataracts. ( 19243831 )
2009
13
Chronic angle-closure glaucoma secondary to a suprachoroidal effusion induced by central retinal vein occlusion. ( 17552395 )
2007
14
Surgical treatment of advanced chronic angle closure glaucoma in Weill-Marchesani syndrome. ( 15478742 )
2004
15
Combined phacoemulsification and goniosynechialysis for uncontrolled chronic angle-closure glaucoma after acute angle-closure glaucoma. ( 10201585 )
1999
16
Familial exudative vitreoretinopathy associated with nonneovascular chronic angle-closure glaucoma. ( 9075081 )
1997
17
Filtering iridocycloretraction in chronic closed-angle glaucoma. ( 3976810 )
1985
18
Sector retinitis pigmentosa and chronic angle-closure glaucoma: a new association. ( 6472800 )
1984
19
Some observations on chronic closed-angle glaucoma. ( 13413136 )
1957

Variations for Chronic Closed-Angle Glaucoma

Expression for Chronic Closed-Angle Glaucoma

Search GEO for disease gene expression data for Chronic Closed-Angle Glaucoma.

Pathways for Chronic Closed-Angle Glaucoma

Pathways related to Chronic Closed-Angle Glaucoma according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.42 BMP7 TGFB2 TGFB3 TIMP1 TNFRSF1A
2
Show member pathways
12.37 AQP1 AQP3 AQP4 AQP5 AQP7 BMP7
3 11.78 CXCL10 EDN1 TNFRSF1A
4
Show member pathways
11.77 AQP1 AQP3 AQP4 AQP5 AQP7
5
Show member pathways
11.73 BMP7 TGFB2 TGFB3 TIMP1 TNFRSF1A
6 11.72 EDN1 EPO TIMP1
7 11.71 EDN1 TGFB2 TGFB3
8 11.64 TGFB2 TGFB3 TIMP1
9 11.64 BMP7 TGFB2 TGFB3
10 11.55 BMP7 TGFB2 TGFB3 TIMP1
11 11.54 AQP1 AQP4 CXCL10 GJA1
12
Show member pathways
11.52 BMP7 TGFB2 TGFB3
13 11.48 CXCL10 TGFB2 TGFB3
14 11.41 BMP7 EDN1 TIMP1
15 11.23 CXCL10 TIMP1 TNFRSF1A
16 11 EDN1 EPO TGFB3
17 10.83 BMP7 CXCL10 TGFB2 TGFB3 TIMP1

GO Terms for Chronic Closed-Angle Glaucoma

Cellular components related to Chronic Closed-Angle Glaucoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum GO:0005783 9.87 ABCC6 AQP5 CTSA GJA1 IER3IP1 MYOC
2 apical plasma membrane GO:0016324 9.67 ABCC6 AQP1 AQP5 GJA1
3 extracellular space GO:0005615 9.61 BMP7 CXCL10 EDN1 EPO MYOC TGFB2
4 basolateral plasma membrane GO:0016323 9.46 ABCC6 AQP1 AQP3 AQP4
5 platelet alpha granule lumen GO:0031093 9.43 TGFB2 TGFB3 TIMP1
6 extracellular region GO:0005576 9.32 BMP7 CTSA CXCL10 EDN1 EPO MYOC

Biological processes related to Chronic Closed-Angle Glaucoma according to GeneCards Suite gene sharing:

(show all 39)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.98 ABCC6 AQP1 EDN1 TGFB2
2 transmembrane transport GO:0055085 9.98 ABCC6 AQP1 AQP3 AQP4 AQP5 AQP7
3 regulation of apoptotic process GO:0042981 9.97 BMP7 PRELID1 TGFB2 TGFB3
4 response to hypoxia GO:0001666 9.91 EDN1 EPO TGFB2 TGFB3
5 response to lipopolysaccharide GO:0032496 9.91 CXCL10 EDN1 EPO GJA1
6 skeletal system development GO:0001501 9.88 BMP7 EDN1 PHEX TGFB2
7 regulation of signaling receptor activity GO:0010469 9.87 BMP7 CXCL10 EDN1 EPO TGFB2 TGFB3
8 platelet degranulation GO:0002576 9.85 TGFB2 TGFB3 TIMP1
9 wound healing GO:0042060 9.85 TGFB2 TGFB3 TIMP1
10 cell-cell signaling GO:0007267 9.85 CXCL10 EDN1 GJA1 PHEX TGFB2
11 neutrophil chemotaxis GO:0030593 9.83 CXCL10 EDN1 TGFB2
12 cellular response to mechanical stimulus GO:0071260 9.83 AQP1 GJA1 TNFRSF1A
13 cartilage development GO:0051216 9.83 BMP7 EDN1 TIMP1
14 cellular response to hypoxia GO:0071456 9.83 AQP1 AQP3 BMP7 EDN1
15 cell development GO:0048468 9.81 BMP7 TGFB2 TGFB3
16 response to peptide hormone GO:0043434 9.8 BMP7 GJA1 TIMP1
17 SMAD protein signal transduction GO:0060395 9.79 BMP7 TGFB2 TGFB3
18 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.77 BMP7 TGFB2 TGFB3
19 positive regulation of epithelial to mesenchymal transition GO:0010718 9.76 BMP7 TGFB2 TGFB3
20 excretion GO:0007588 9.73 AQP3 AQP5 AQP7
21 regulation of MAPK cascade GO:0043408 9.71 BMP7 MYOC TGFB2 TGFB3
22 renal water homeostasis GO:0003091 9.69 AQP1 AQP3 AQP4
23 secondary palate development GO:0062009 9.67 TGFB2 TGFB3
24 response to dexamethasone GO:0071548 9.66 EDN1 EPO
25 cellular response to parathyroid hormone stimulus GO:0071374 9.65 GJA1 PHEX
26 cell-cell junction organization GO:0045216 9.65 GJA1 TGFB2 TGFB3
27 multicellular organismal water homeostasis GO:0050891 9.64 AQP1 AQP4
28 cellular hyperosmotic response GO:0071474 9.63 AQP1 EPO
29 pancreatic juice secretion GO:0030157 9.63 AQP1 AQP5
30 negative regulation of macrophage cytokine production GO:0010936 9.59 TGFB2 TGFB3
31 carbon dioxide transport GO:0015670 9.57 AQP1 AQP5
32 nitric oxide transport GO:0030185 9.54 AQP1 EDN1
33 salivary gland morphogenesis GO:0007435 9.54 BMP7 TGFB2 TGFB3
34 uterine wall breakdown GO:0042704 9.49 TGFB2 TGFB3
35 response to vitamin D GO:0033280 9.46 AQP3 BMP7 CXCL10 PHEX
36 glycerol transport GO:0015793 9.43 AQP1 AQP3 AQP7
37 odontogenesis GO:0042476 9.35 AQP1 AQP3 AQP5 TGFB2 TGFB3
38 water transport GO:0006833 9.02 AQP1 AQP3 AQP4 AQP5 AQP7
39 positive regulation of cell proliferation GO:0008284 10.02 CXCL10 EDN1 EPO TGFB2 TGFB3 TIMP1

Molecular functions related to Chronic Closed-Angle Glaucoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.71 BMP7 TGFB2 TGFB3 TIMP1
2 cytokine activity GO:0005125 9.7 BMP7 CXCL10 EDN1 EPO TGFB2 TGFB3
3 transforming growth factor beta receptor binding GO:0005160 9.54 BMP7 TGFB2 TGFB3
4 type II transforming growth factor beta receptor binding GO:0005114 9.46 TGFB2 TGFB3
5 water transmembrane transporter activity GO:0005372 9.43 AQP1 AQP4
6 channel activity GO:0015267 9.35 AQP1 AQP3 AQP4 AQP5 AQP7
7 glycerol channel activity GO:0015254 9.32 AQP3 AQP7
8 type III transforming growth factor beta receptor binding GO:0034714 9.26 TGFB2 TGFB3
9 water channel activity GO:0015250 9.02 AQP1 AQP3 AQP4 AQP5 AQP7

Sources for Chronic Closed-Angle Glaucoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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