MCID: CHR058
MIFTS: 26

Chronic Congestive Splenomegaly

Categories: Blood diseases, Immune diseases
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Aliases & Classifications for Chronic Congestive Splenomegaly

Summaries for Chronic Congestive Splenomegaly

MalaCards based summary: Chronic Congestive Splenomegaly is related to splenomegaly and surfactant dysfunction. An important gene associated with Chronic Congestive Splenomegaly is ACR (Acrosin), and among its related pathways/superpathways are Diseases of glycosylation and Surfactant metabolism. Affiliated tissues include spleen, and related phenotypes are homeostasis/metabolism and neoplasm

Related Diseases for Chronic Congestive Splenomegaly

Diseases related to Chronic Congestive Splenomegaly via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Related Disease Score Top Affiliating Genes
1 splenomegaly 10.3
2 surfactant dysfunction 10.3 SFTPC ABCA3
3 respiratory distress syndrome in premature infants 10.3 SFTPC ABCA3
4 hereditary pulmonary alveolar proteinosis 10.3 SFTPC ABCA3
5 pulmonary interstitial emphysema 10.2 SFTPC ABCA3
6 lipid pneumonia 10.2 SFTPC ABCA3
7 pulmonary immaturity 10.2 SFTPC ABCA3
8 interstitial pneumonitis, desquamative, familial 10.2 SFTPC ABCA3
9 neonatal respiratory failure 10.2 SFTPC ABCA3
10 pulmonary alveolar microlithiasis 10.2 SLC34A2 ABCA3
11 nutmeg liver 10.2 ALB ACR
12 pulmonary hemosiderosis 10.1 SLC34A2 SFTPC ABCA3
13 nonspecific interstitial pneumonia 10.1 SFTPC ABCA3
14 tuberculous empyema 10.1 AVPR2 ALB
15 acquired hemangioma 10.1 CD34 ACR
16 colonic lymphangioma 10.1 CD34 ACR
17 central pontine myelinolysis 10.1 AVPR2 ALB
18 supine hypotensive syndrome 10.1 ALB ACR
19 volvulus of midgut 10.1 ALB ACR
20 secondary hypertrophic osteoarthropathy 10.1 SLC34A2 CD34
21 familial adenomatous polyposis 1 10.1 PMS2 AVPR2
22 dipetalonemiasis 10.1 MT-CO1 ALB
23 capillariasis 10.1 MT-CO1 ALB
24 epilepsy, familial temporal lobe, 2 10.0 MT-CO1 BCHE
25 nemaline myopathy 3 10.0 MT-CO1 ALB
26 chronic meningitis 10.0 MT-CO1 ALB
27 inappropriate adh syndrome 10.0 AVPR2 ALB
28 meningovascular neurosyphilis 10.0 MT-CO1 ALB
29 newborn respiratory distress syndrome 10.0 SFTPC ALB ABCA3
30 tick infestation 10.0 MT-CO1 ALB
31 bartonellosis 10.0 MT-CO1 CD34
32 taeniasis 10.0 MT-CO1 ALB
33 peliosis hepatis 9.9 CD34 ALB
34 bile duct cystadenoma 9.9 CD34 ALB
35 cervical adenosarcoma 9.9 PMS2 CD34
36 pulmonary hypertension, primary, 1 9.9 PMS2 ABCA3
37 liver leiomyosarcoma 9.9 CD34 ALB
38 meckel diverticulum 9.9 CD34 ALB
39 babesiosis 9.9 MT-CO1 ALB
40 parasitic ectoparasitic infectious disease 9.9 MT-CO1 ALB
41 hemorrhagic cystitis 9.9 CD34 ALB
42 fascioliasis 9.8 MT-CO1 ALB
43 beta-thalassemia major 9.8 HFE CD34 ALB
44 occupational asthma 9.8 IL33 ALB
45 environmental induced asthma 9.8 IL33 ALB
46 hemoglobinopathy 9.8 HFE CD34 ALB
47 respiratory failure 9.7 SFTPC PMS2 ALB ABCA3
48 pancytopenia 9.7 DKC1 CD34 ALB
49 parasitic helminthiasis infectious disease 9.6 MT-CO1 IL33 ALB
50 cecal disease 9.6 CD34 ALB

Comorbidity relations with Chronic Congestive Splenomegaly via Phenotypic Disease Network (PDN):


Alcoholic Liver Cirrhosis Deficiency Anemia
Hypersplenism Portal Hypertension

Graphical network of the top 20 diseases related to Chronic Congestive Splenomegaly:



Diseases related to Chronic Congestive Splenomegaly

Symptoms & Phenotypes for Chronic Congestive Splenomegaly

GenomeRNAi Phenotypes related to Chronic Congestive Splenomegaly according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.11 ABCA3 ACR ALB AVPR2 BCHE CD34
2 no effect GR00402-S-2 10.11 ACR ALB AVPR2 BCHE CD34 CXCL5

MGI Mouse Phenotypes related to Chronic Congestive Splenomegaly:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.83 ABCA3 ALB AVPR2 BCHE CD34 CXCL5
2 neoplasm MP:0002006 9.63 ALB CD34 DKC1 GPC1 PMS2 SFTPC
3 mortality/aging MP:0010768 9.4 ABCA3 ALB AVPR2 BCHE CXCL5 DKC1

Drugs & Therapeutics for Chronic Congestive Splenomegaly

Search Clinical Trials, NIH Clinical Center for Chronic Congestive Splenomegaly

Genetic Tests for Chronic Congestive Splenomegaly

Anatomical Context for Chronic Congestive Splenomegaly

Organs/tissues related to Chronic Congestive Splenomegaly:

MalaCards : Spleen

Publications for Chronic Congestive Splenomegaly

Articles related to Chronic Congestive Splenomegaly:

# Title Authors PMID Year
1
Rare case of upper gastrointestinal hemorrhage due to accessory spleen: A case report. 62
35945721 2022
2
[The clinical application of splenectomy in pyrexia of unknown origin with splenomegaly]. 62
15840216 2005
3
[Chronic congestive splenomegaly secondary to aneurysm of the splenic artery]. 62
2091708 1990
4
Chronic congestive splenomegaly (Banti-like syndrome) in a dog. 62
13949648 1963
5
[Contribution to the pathogenesis of microcytic hypochromic non-post-hemorrhagic anemia during chronic congestive splenomegaly]. 62
14483487 1962
6
Chronic congestive splenomegaly with early jaundice. 62
13168205 1954

Variations for Chronic Congestive Splenomegaly

Expression for Chronic Congestive Splenomegaly

Search GEO for disease gene expression data for Chronic Congestive Splenomegaly.

Pathways for Chronic Congestive Splenomegaly

GO Terms for Chronic Congestive Splenomegaly

Cellular components related to Chronic Congestive Splenomegaly according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lamellar body GO:0042599 9.26 SFTPC ABCA3
2 alveolar lamellar body GO:0097208 8.92 SFTPC ABCA3

Biological processes related to Chronic Congestive Splenomegaly according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of immunoglobulin production GO:0002638 8.92 TMBIM6 IL33

Molecular functions related to Chronic Congestive Splenomegaly according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 copper ion binding GO:0005507 9.43 GPC1 ALB ACR
2 telomerase activity GO:0003720 8.92 TERF2 DKC1

Sources for Chronic Congestive Splenomegaly

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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