MCID: CHR086
MIFTS: 40

Chronic Conjunctivitis

Categories: Eye diseases, Immune diseases, Infectious diseases, Neuronal diseases, Rare diseases
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Aliases & Classifications for Chronic Conjunctivitis

MalaCards integrated aliases for Chronic Conjunctivitis:

Name: Chronic Conjunctivitis 11 53 14 71 31

Classifications:



External Ids:

Disease Ontology 11 DOID:2475
ICD9CM 34 372.1
NCIt 49 C35197
SNOMED-CT 68 155163007
ICD10 31 H10.4
UMLS 71 C0155145

Summaries for Chronic Conjunctivitis

MalaCards based summary : Chronic Conjunctivitis is related to vernal conjunctivitis and lymphoma, mucosa-associated lymphoid type. An important gene associated with Chronic Conjunctivitis is FCER2 (Fc Epsilon Receptor II), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. Affiliated tissues include eye, and related phenotypes are homeostasis/metabolism and immune system

Related Diseases for Chronic Conjunctivitis

Diseases in the Conjunctivitis family:

Acute Conjunctivitis Chronic Conjunctivitis
Bacterial Conjunctivitis Rare Conjunctivitis

Diseases related to Chronic Conjunctivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 851)
# Related Disease Score Top Affiliating Genes
1 vernal conjunctivitis 30.1 MUC5AC IL4 CCL11
2 lymphoma, mucosa-associated lymphoid type 30.1 ICOSLG CXCL8 CD4 CCR6
3 conjunctivitis 30.0 TNF RNASE3 IL6 IL5 IL4 IL33
4 relapsing polychondritis 30.0 TNF IL6 CD4
5 chronic rhinitis 30.0 RNASE3 IL5 IL4 IL33 IL13 HRH1
6 scleritis 29.9 TNFSF4 TNF IL5 IL4 CCR6
7 blepharoconjunctivitis 29.8 TNFSF4 IL4 IL13 CD4
8 bullous pemphigoid 29.8 RNASE3 IL5 IL13 FCER2 CCR6 CCL11
9 trachoma 29.8 TNF IL6 IL4 IL17A IL10
10 papillary conjunctivitis 29.6 RNASE3 MUC5AC IL5 IL4 IL13 CXCL8
11 igg4-related disease 29.5 IL5 IL4 IL13 IL10 ICOSLG CD4
12 chlamydia 29.3 TNF IL6 IL5 IL4 IL1B IL17A
13 bacterial conjunctivitis 29.2 TNF IL6 IL1B IL10 CXCL8 CD4
14 urethritis 29.2 TNF IL6 IL1B IL10 CXCL8 CD4
15 rosacea 29.0 TNF IL6 IL33 IL1B IL17A CXCL8
16 vasculitis 29.0 TNF IL6 IL1B IL17A IL10 CXCL8
17 acne 28.9 TNF IL6 IL1B IL17A IL10 CXCL8
18 vaginitis 28.7 TNF IL6 IL1B IL17A IL10 CXCL8
19 uveitis 28.6 TNF IL6 IL4 IL1B IL17A IL10
20 corneal disease 28.6 TNF IL6 IL1B IL17A IL10 CXCL8
21 keratitis, hereditary 28.6 TNF IL6 IL1B IL17A IL10 CXCL8
22 allergic conjunctivitis 28.5 TSLP TNFSF4 TNF RNASE3 MUC5AC IL6
23 dry eye syndrome 28.3 TNF MUC5AC IL6 IL1B IL17A IL10
24 pemphigoid 28.2 TNF RNASE3 IL6 IL5 IL4 IL1B
25 rhinitis 27.6 TSLP TNF RNASE3 IL6 IL5 IL4
26 urticaria 27.5 TSLP TNF RNASE3 IL6 IL5 IL4
27 dermatitis 27.3 TSLP TNF RNASE3 IL6 IL5 IL4
28 allergic disease 27.3 TSLP TNF RNASE3 IL6 IL5 IL4
29 dermatitis, atopic 26.7 TSLP TNFSF4 TNF RNASE3 IL6 IL5
30 simple chronic conjunctivitis 11.3
31 lacrimoauriculodentodigital syndrome 11.2
32 inclusion conjunctivitis 11.2
33 ligneous conjunctivitis 11.0
34 aztreonam allergy 10.4 IL5 IL13
35 cefuroxime allergy 10.4 IL5 IL13
36 cefaclor allergy 10.3 IL5 IL13
37 proliferative glomerulonephritis 10.3 ICOSLG CD4 CCR6
38 respiratory syncytial virus infectious disease 10.3 IL5 IL13
39 aspirin-induced respiratory disease 10.3 RNASE3 IL5 IL13
40 loeffler endocarditis 10.3 RNASE3 IL5
41 angiostrongyliasis 10.3 IL5 IL13 CCL11
42 kimura disease 10.3 RNASE3 IL5 IL4
43 paragonimiasis 10.3 RNASE3 IL5 IL13
44 immunodeficiency 14 10.3 ICOSLG CD4 CCR6
45 loeffler syndrome 10.3 IL5 IL33 IL13
46 neurodermatitis 10.3 TSLP IL4 IL13
47 external pathological resorption 10.3 TNF IL6
48 pernicious anemia 10.3 ICOSLG CD4 CCR6
49 angioimmunoblastic t-cell lymphoma 10.3 ICOSLG CD4 CCR6
50 chronic atticoantral disease 10.3 TNF MUC5AC

Comorbidity relations with Chronic Conjunctivitis via Phenotypic Disease Network (PDN):


Acute Cystitis Heart Disease

Graphical network of the top 20 diseases related to Chronic Conjunctivitis:



Diseases related to Chronic Conjunctivitis

Symptoms & Phenotypes for Chronic Conjunctivitis

MGI Mouse Phenotypes related to Chronic Conjunctivitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.25 CCR6 CD4 FCER2 HRH1 ICOSLG IL10
2 immune system MP:0005387 10.11 CCL11 CCR6 CD4 FCER2 HRH1 ICOSLG
3 digestive/alimentary MP:0005381 10.03 CD4 FCER2 IL10 IL13 IL17A IL33
4 no phenotypic analysis MP:0003012 9.91 CD4 IL10 IL13 IL17A IL33 IL4
5 respiratory system MP:0005388 9.65 CCL11 IL10 IL13 IL17A IL33 IL4
6 hematopoietic system MP:0005397 9.55 CCL11 CCR6 CD4 FCER2 HRH1 ICOSLG

Drugs & Therapeutics for Chronic Conjunctivitis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety and Feasibility of the Cornea DomeLens Ocular Surface Imaging System Recruiting NCT05461469

Search NIH Clinical Center for Chronic Conjunctivitis

Genetic Tests for Chronic Conjunctivitis

Anatomical Context for Chronic Conjunctivitis

Organs/tissues related to Chronic Conjunctivitis:

MalaCards : Eye

Publications for Chronic Conjunctivitis

Articles related to Chronic Conjunctivitis:

(show top 50) (show all 289)
# Title Authors PMID Year
1
Correlation between tear IgE levels and HLA-DR expression by conjunctival cells in allergic and nonallergic chronic conjunctivitis. 53 62
11148813 2000
2
[Measurement of total IgE in tears : the adaptation of an immunoenzyme technique and the value of investigating locally produced IgE in the diagnosis of chronic conjunctivitis]. 53 62
10432371 1999
3
[Value of lacrymal IgE determination and conjunctival cytology in the diagnosis of chronic conjunctivitis]. 53 62
9759406 1998
4
Flow cytometry in impression cytology specimens. A new method for evaluation of conjunctival inflammation. 53 62
9191610 1997
5
Immunophenotyping of human dendriform cells from the conjunctival epithelium. 53 62
9154386 1997
6
Symblepharon, Ankyloblepharon, and Salt Gland Dysfunction in a Loggerhead Sea Turtle (Caretta caretta). 62
35737333 2022
7
Atypical ocular Chlamydia trachomatis infections in two patients attending in a second-level hospital: A case report. 62
35623592 2022
8
Mucus fishing syndrome. 62
35396241 2022
9
The first Moroccan case of severe type II congenital plasminogen deficiency with ligneous conjunctivitis. 62
35225240 2022
10
Bilateral, chronic, bacterial conjunctivitis in giant fornix syndrome. 62
35027379 2022
11
Risk factors for the progression of trachomatous scarring in a cohort of women in a trachoma low endemic district in Tanzania. 62
34797827 2021
12
Chronic Early-Stage Ocular Cicatricial Pemphigoid. 62
34293790 2021
13
Sequelae of microsporidial keratoconjunctivitis and its management. 62
34011737 2021
14
RNR inhibitor binding studies of Chlamydia felis: insights from in silico molecular modeling, docking, and simulation studies. 62
34032189 2021
15
Punctal Congestion Syndrome: A Reversible, Functional Punctal Stenosis Causing Epiphora in the Setting of Chronic Pretarsal Conjunctivitis. 62
32890120 2021
16
Treatment of ligneous conjunctivitis with fresh frozen plasm in twin babies. 62
33348042 2021
17
[Pathogenetic and clinical aspects of floppy eyelid syndrome]. 62
33610157 2021
18
Chlamydia trachomatis Mimicking COVID-19 Chronic Follicular Conjunctivitis. 62
33604091 2021
19
Is oxidative stress involved in vernal keratoconjunctivitis? Results from a pilot study in children. 62
33236421 2020
20
Complicated case of Mycobacterium abscessus conjunctivitis in Sjögren's syndrome. 62
32548334 2020
21
High throughput sequencing reveals high specificity of TNFAIP3 mutations in ocular adnexal marginal zone B-cell lymphomas. 62
32012328 2020
22
Milestones in the fight to eliminate trachoma. 62
32017172 2020
23
Chronic Conjunctivitis From a Retained Contact Lens. 62
30724838 2020
24
Chronic Conjunctivitis in an Older Patient With Ptosis. 62
31725837 2020
25
Dry Eyes Status on Des Scale and Related Factors in Outpatients at Vietnam National Institute of Ophthalmology. 62
32215080 2019
26
Chronic conjunctivitis as a prognosis factor of dacryocystorhinostomy: a retrospective case-controlled study. 62
31358137 2019
27
Molecular Detection of Chlamydia felis in Cats in Ahvaz, Iran. 62
31232561 2019
28
Ocular Cicatricial Pemphigoid: Camouflaged as Persistent Conjunctivitis. 62
31142415 2019
29
Exclusively ocular and cardiac manifestation of granulomatosis with polyangiitis - a case report. 62
31253129 2019
30
Brimonidine-induced unilateral ocular lichen planus: a case report. 62
30916215 2019
31
Outcome of External Dacryocystorhinostomy and Monocanalicular Intubation in Patients with Total Obstruction of One Canalicus. 62
30977323 2019
32
Granulomatous Uveitis and Conjunctivitis Due to Common Variable Immune Deficiency: A Case Report. 62
30142001 2019
33
Sleep Disorders are a Prevalent and Serious Comorbidity in Dry Eye. 62
30481819 2018
34
Clinical, histopathological, and genetic aspects in one case of ligneous conjunctivitis. 62
30058940 2018
35
Feline Herpesvirus 1 US3 Blocks the Type I Interferon Signal Pathway by Targeting Interferon Regulatory Factor 3 Dimerization in a Kinase-Independent Manner. 62
29618645 2018
36
Pediatric self-inflicted eye trauma due to a major depressive disorder. 62
29997760 2018
37
Primary Conjunctiva Tuberculosis and Review of Literature. 62
33601773 2018
38
Management of patients with ocular manifestations in vesiculobullous disorders affecting the mouth. 62
27717107 2017
39
Eyelid Molluscum Contagiosum Lesions in Two Patients with Unilateral Chronic Conjunctivitis. 62
28845328 2017
40
Clinical efficacy of nutraceutical diet for cats with clinical signs of cutaneus adverse food reaction (CAFR). 62
28865210 2017
41
Sensitization from ketotifen fumarate in eye drops presenting as chronic conjunctivitis. 62
28095628 2017
42
Pediatric conjunctival lymphoma associated with oral carbamazepine use. 62
29503903 2016
43
Successful Treatment with Chronic Conjunctivitis: Removal of Tarsoconjunctival Crypt. 62
27478360 2016
44
Chronic tarsal conjunctivitis. 62
27473439 2016
45
Stevens-Johnson syndrome: The role of an ophthalmologist. 62
26829569 2016
46
Keratoconjunctivitis sicca exacerbation in a dog treated with systemic atenolol. 62
27071733 2016
47
Sleep and mood disorders in dry eye disease and allied irritating ocular diseases. 62
26927330 2016
48
Primary conjunctival follicular lymphoma mimicking chronic conjunctivitis. 62
26560164 2016
49
Clinical features and in vivo confocal microscopy assessment in 12 patients with ocular cicatricial pemphigoid. 62
27275431 2016
50
Canaliculitis Awareness. 62
27800254 2016

Variations for Chronic Conjunctivitis

Expression for Chronic Conjunctivitis

Search GEO for disease gene expression data for Chronic Conjunctivitis.

Pathways for Chronic Conjunctivitis

Pathways related to Chronic Conjunctivitis according to GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.96 CCL11 CCR6 CD4 CXCL8 FCER2 ICOSLG
2
Show member pathways
13.89 TNFSF4 TNF IL6 IL5 IL4 IL1B
3 13.79 TNF IL6 IL5 IL33 HRH1 FCER2
4
Show member pathways
13.69 CCL11 CCR6 CD4 CXCL8 FCER2 IL10
5
Show member pathways
13.64 TNF IL6 IL5 IL4 IL1B IL17A
6
Show member pathways
13.5 CCL11 CCR6 CD4 CXCL8 IL10 IL13
7
Show member pathways
13.39 CCL11 CCR6 CD4 CXCL8 IL10 IL13
8
Show member pathways
13.21 TSLP TNFSF4 TNF IL6 IL5 IL4
9
Show member pathways
12.75 CXCL8 IL10 IL13 IL17A IL1B IL4
10
Show member pathways
12.72 TNF MUC5AC IL6 IL33 IL1B CXCL8
11
Show member pathways
12.69 CD4 IL10 IL17A IL1B IL6 TNF
12 12.67 TNFSF4 TNF IL4 IL1B IL17A IL10
13
Show member pathways
12.55 TNF IL6 IL4 IL1B CXCL8 CCL11
14
Show member pathways
12.52 TNF IL6 IL1B CXCL8
15
Show member pathways
12.38 CXCL8 IL17A IL6 MUC5AC TNF
16
Show member pathways
12.32 TNF IL6 IL1B CXCL8
17 12.31 CXCL8 IL10 IL13 IL1B IL6 TNF
18
Show member pathways
12.29 TNF IL5 IL4 IL17A IL10 CD4
19 12.23 IL10 IL13 IL1B IL4 IL6 TNF
20 12.14 TNF IL6 IL5 IL4 IL10 CD4
21 12.13 TNF IL6 IL4 IL1B CXCL8
22 12.1 IL10 FCER2 CXCL8 CCL11 IL13 IL17A
23
Show member pathways
12.06 TNF IL6 IL1B IL17A IL10 CD4
24 12.03 CXCL8 IL10 IL13 IL17A IL1B IL4
25
Show member pathways
12.01 CD4 IL17A IL1B IL4 IL6
26 11.99 IL6 IL10 CXCL8 CCR6
27 11.97 TSLP TNF IL5 IL4 IL33 IL1B
28 11.94 IL6 IL5 IL4 IL13 CXCL8
29 11.91 TNF IL6 IL1B IL10 CD4
30 11.88 IL6 IL4 IL1B IL17A CD4
31 11.87 IL6 IL5 IL4 IL10 CXCL8
32 11.84 TNF IL6 IL1B CXCL8
33
Show member pathways
11.82 TNF IL5 IL4 CXCL8
34 11.81 TNFSF4 TNF IL6 IL1B IL10
35
Show member pathways
11.81 TNF IL6 IL5 IL4 IL13 IL10
36 11.81 CCL11 CXCL8 IL13 IL1B IL4 IL5
37
Show member pathways
11.79 TNF IL6 IL1B CXCL8
38 11.79 IL5 IL4 IL10 FCER2 CCL11
39
Show member pathways
11.78 IL6 CXCL8 CD4
40 11.78 TNF IL6 IL10 CXCL8
41 11.76 CD4 IL10 IL6
42 11.7 TNF IL6 IL1B IL10 FCER2 CXCL8
43 11.61 TNF IL4 IL10 CD4
44 11.6 TNF IL10 CXCL8
45 11.57 TNF IL6 CXCL8
46 11.54 TNF IL6 IL1B
47 11.51 IL10 IL1B IL6 TNF
48 11.46 TNF IL6 IL1B CXCL8
49 11.42 TNF IL6 IL1B IL17A CXCL8
50 11.38 TNFSF4 IL5 IL4 IL13 IL10

GO Terms for Chronic Conjunctivitis

Cellular components related to Chronic Conjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.1 CCL11 CXCL8 FCER2 IL10 IL13 IL17A
2 external side of plasma membrane GO:0009897 10 TNF IL17A IL13 ICOSLG FCER2 CD4
3 extracellular space GO:0005615 9.8 CCL11 CXCL8 IL10 IL13 IL17A IL1B

Biological processes related to Chronic Conjunctivitis according to GeneCards Suite gene sharing:

(show all 43)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 10.47 TNF IL6 IL4 IL33 IL1B IL13
2 signal transduction GO:0007165 10.47 CCL11 CCR6 CD4 CXCL8 HRH1 ICOSLG
3 inflammatory response GO:0006954 10.32 TNFSF4 TNF IL6 IL5 IL1B IL17A
4 positive regulation of DNA-binding transcription factor activity GO:0051091 10.29 IL10 IL1B IL5 IL6 TNF
5 defense response to Gram-positive bacterium GO:0050830 10.28 TNF RNASE3 IL6 IL1B IL17A
6 positive regulation of inflammatory response GO:0050729 10.27 TSLP TNFSF4 TNF IL33 IL1B
7 cellular response to lipopolysaccharide GO:0071222 10.26 CXCL8 IL10 IL1B IL6 TNF TNFSF4
8 calcium-mediated signaling GO:0019722 10.23 TNF CXCL8 CD4 CCR6
9 positive regulation of T cell proliferation GO:0042102 10.21 IL1B IL4 IL6 TNFSF4
10 defense response to Gram-negative bacterium GO:0050829 10.19 TSLP RNASE3 IL6 IL17A CD4
11 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 10.18 IL13 IL4 IL6 TNF TSLP
12 positive regulation of receptor signaling pathway via JAK-STAT GO:0046427 10.17 TNF IL6 IL5 IL10
13 negative regulation of interferon-gamma production GO:0032689 10.16 TNFSF4 IL33 IL10
14 positive regulation of cytokine production GO:0001819 10.15 TNFSF4 TNF IL33 IL1B IL10
15 negative regulation of endothelial cell apoptotic process GO:2000352 10.14 IL10 IL13 IL4
16 liver regeneration GO:0097421 10.14 TNF IL6 IL10
17 positive regulation of interleukin-10 production GO:0032733 10.13 IL13 IL4 IL6 TNFSF4 TSLP
18 microglial cell activation GO:0001774 10.12 IL13 IL4 TNF
19 positive regulation of cytokine production involved in inflammatory response GO:1900017 10.11 IL17A IL6 TNF
20 negative regulation of neurogenesis GO:0050768 10.11 TNF IL6 IL1B CCL11
21 positive regulation of macrophage activation GO:0043032 10.1 IL10 IL13 IL33
22 positive regulation of interleukin-6 production GO:0032755 10.1 IL17A IL1B IL33 IL6 TNF TNFSF4
23 positive regulation of glial cell proliferation GO:0060252 10.09 TNF IL6 IL1B
24 positive regulation of heterotypic cell-cell adhesion GO:0034116 10.08 TNF IL1B IL10
25 positive regulation of MHC class II biosynthetic process GO:0045348 10.08 IL4 IL33 IL10
26 positive regulation of interleukin-13 production GO:0032736 10.06 TSLP TNFSF4 IL4 IL33
27 vascular endothelial growth factor production GO:0010573 10.03 IL1B IL6 TNF
28 type 2 immune response GO:0042092 10.02 IL10 IL33 IL4
29 positive regulation of neuroinflammatory response GO:0150078 10.01 TNF IL6 IL33 IL1B
30 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 9.99 TNF FCER2
31 positive regulation of type 2 immune response GO:0002830 9.99 TNFSF4 IL33
32 negative regulation of cytokine production involved in immune response GO:0002719 9.98 IL10 TNF
33 positive regulation of receptor signaling pathway via STAT GO:1904894 9.98 IL6 TSLP
34 positive regulation of mononuclear cell migration GO:0071677 9.98 TNF IL4
35 positive regulation of fever generation GO:0031622 9.97 TNF IL1B
36 regulation of isotype switching GO:0045191 9.97 IL4 IL10
37 sequestering of triglyceride GO:0030730 9.97 TNF IL1B
38 negative regulation of complement-dependent cytotoxicity GO:1903660 9.96 IL4 IL13
39 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.95 TNF IL1B
40 chronic inflammatory response to antigenic stimulus GO:0002439 9.95 TNF IL10
41 positive regulation of chemokine production GO:0032722 9.9 TSLP TNFSF4 TNF IL6 IL33 IL1B
42 positive regulation of immunoglobulin production GO:0002639 9.73 IL10 IL13 IL33 IL5 IL6 TNFSF4
43 immune response GO:0006955 9.64 TNFSF4 TNF IL6 IL5 IL4 IL1B

Molecular functions related to Chronic Conjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.7 TSLP TNFSF4 TNF IL6 IL5 IL4

Sources for Chronic Conjunctivitis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 04-Aug-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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