MCID: CHR086
MIFTS: 42

Chronic Conjunctivitis

Categories: Eye diseases, Immune diseases, Infectious diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Chronic Conjunctivitis

MalaCards integrated aliases for Chronic Conjunctivitis:

Name: Chronic Conjunctivitis 12 54 15 70 32

Classifications:



External Ids:

Disease Ontology 12 DOID:2475
ICD9CM 34 372.1
NCIt 50 C35197
SNOMED-CT 67 155163007
ICD10 32 H10.4
UMLS 70 C0155145

Summaries for Chronic Conjunctivitis

MalaCards based summary : Chronic Conjunctivitis is related to scleritis and papillary conjunctivitis. An important gene associated with Chronic Conjunctivitis is IGHE (Immunoglobulin Heavy Constant Epsilon), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. Affiliated tissues include eye, bone and skin, and related phenotypes are hematopoietic system and digestive/alimentary

Related Diseases for Chronic Conjunctivitis

Diseases in the Conjunctivitis family:

Acute Conjunctivitis Chronic Conjunctivitis
Bacterial Conjunctivitis Rare Conjunctivitis

Diseases related to Chronic Conjunctivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 668)
# Related Disease Score Top Affiliating Genes
1 scleritis 30.0 TNF IL5 IL4 CCR6
2 papillary conjunctivitis 30.0 IL6 IL4 CXCL8 CCL11
3 allergic conjunctivitis 30.0 TNF RNASE3 IL5 IL4 IL33 IL13
4 igg4-related disease 30.0 IL4 IL33 ICOSLG CCR6
5 trachoma 29.9 TNF IL6 IL4 IL10
6 lymphoma, mucosa-associated lymphoid type 29.8 ICOSLG CXCL8 CD4 CCR6
7 vernal conjunctivitis 29.8 RNASE3 MUC5AC IL4 IGHE CCR6
8 relapsing polychondritis 29.7 IL6 IL10 CXCL8
9 chlamydia 29.7 TNF IL6 IL5 IL4 IL10 CXCL8
10 pemphigoid 29.6 TNF IL5 IL4 IL13 CCL11
11 dry eye syndrome 29.5 TNF MUC5AC IL6 CCR6
12 bacterial conjunctivitis 29.4 TNF IL6 IL10 CXCL8
13 conjunctivitis 29.3 TNF RNASE3 IL6 IL5 IL4 IL33
14 rosacea 29.3 TNF IL6 IL33 CXCL8 CCR6
15 urethritis 29.1 TNF IL6 IL10 CXCL8 CD4
16 uveitis 29.0 TNF IL6 IL4 IL10 CXCL8 CCL11
17 vaginitis 28.9 TNF IL6 IL10 CXCL8 CD4 CCR6
18 corneal disease 28.9 TNF IL6 IL10 CXCL8 CD4 CCR6
19 keratitis, hereditary 28.9 TNF IL6 IL10 CXCL8 CD4 CCR6
20 urticaria 28.0 TNF RNASE3 IL6 IL5 IL4 IL13
21 rhinitis 27.6 TSLP TNF RNASE3 IL6 IL5 IL4
22 allergic disease 27.3 TSLP TNF RNASE3 IL6 IL5 IL4
23 dermatitis 27.2 TSLP TNF RNASE3 IL6 IL5 IL4
24 asthma 26.6 TSLP TNF RNASE3 MUC5AC IL6 IL5
25 dermatitis, atopic 26.4 TSLP TNF RNASE3 IL6 IL5 IL4
26 simple chronic conjunctivitis 11.2
27 ligneous conjunctivitis 11.0
28 persistent polyclonal b-cell lymphocytosis 10.4 IL4 FCER2
29 cytokine deficiency 10.4 IL5 IL13
30 aztreonam allergy 10.4 IL5 IL13
31 cefaclor allergy 10.4 IL5 IL13
32 cefuroxime allergy 10.4 IL5 IL13
33 respiratory syncytial virus infectious disease 10.4 IL5 IL13
34 loeffler endocarditis 10.4 RNASE3 IL5
35 childhood-onset asthma 10.3 RNASE3 IL13 IGHE
36 acute asthma 10.3 RNASE3 IL5 IL4
37 vasomotor rhinitis 10.3 RNASE3 IL5 IL13
38 exercise-induced bronchoconstriction 10.3 RNASE3 IL13
39 eosinophilic gastritis 10.3 IL5 IL13 CCL11
40 patulous eustachian tube 10.3 RNASE3 IL5 CCL11
41 pemphigoid gestationis 10.3 RNASE3 IL5 CCL11
42 neurodermatitis 10.3 TSLP IL4 IL13
43 loeffler syndrome 10.3 IL5 IL33 IL13
44 toxic oil syndrome 10.3 IL5 IL4 IGHE FCER2
45 psoriasis 15 10.3 TSLP IL4 IL13
46 idiopathic nephrotic syndrome 10.3 IL6 IL4 IGHE
47 b-cell growth factor 10.3 IL6 IL4
48 chronic inducible urticaria 10.3 TSLP IL5
49 autoimmune glomerulonephritis 10.3 ICOSLG CD4 CCR6
50 norwegian scabies 10.3 IL5 CD4

Comorbidity relations with Chronic Conjunctivitis via Phenotypic Disease Network (PDN):


Acute Cystitis Heart Disease

Graphical network of the top 20 diseases related to Chronic Conjunctivitis:



Diseases related to Chronic Conjunctivitis

Symptoms & Phenotypes for Chronic Conjunctivitis

MGI Mouse Phenotypes related to Chronic Conjunctivitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.13 CCL11 CCR6 CD4 CRLF2 FCER2 HRH1
2 digestive/alimentary MP:0005381 10.1 CD4 CRLF2 FCER2 IL10 IL13 IL33
3 homeostasis/metabolism MP:0005376 10.03 CCR6 CD4 CRLF2 FCER2 HRH1 IL10
4 immune system MP:0005387 9.86 CCL11 CCR6 CD4 CRLF2 FCER2 HRH1
5 respiratory system MP:0005388 9.32 CCL11 CRLF2 IL10 IL13 IL33 IL4

Drugs & Therapeutics for Chronic Conjunctivitis

Search Clinical Trials , NIH Clinical Center for Chronic Conjunctivitis

Genetic Tests for Chronic Conjunctivitis

Anatomical Context for Chronic Conjunctivitis

MalaCards organs/tissues related to Chronic Conjunctivitis:

40
Eye, Bone, Skin, Lung, Thymus, Spinal Cord, Bone Marrow

Publications for Chronic Conjunctivitis

Articles related to Chronic Conjunctivitis:

(show top 50) (show all 280)
# Title Authors PMID Year
1
Correlation between tear IgE levels and HLA-DR expression by conjunctival cells in allergic and nonallergic chronic conjunctivitis. 61 54
11148813 2000
2
[Measurement of total IgE in tears : the adaptation of an immunoenzyme technique and the value of investigating locally produced IgE in the diagnosis of chronic conjunctivitis]. 61 54
10432371 1999
3
[Value of lacrymal IgE determination and conjunctival cytology in the diagnosis of chronic conjunctivitis]. 61 54
9759406 1998
4
Flow cytometry in impression cytology specimens. A new method for evaluation of conjunctival inflammation. 54 61
9191610 1997
5
Immunophenotyping of human dendriform cells from the conjunctival epithelium. 54 61
9154386 1997
6
Treatment of ligneous conjunctivitis with fresh frozen plasm in twin babies. 61
33348042 2021
7
Chlamydia trachomatis Mimicking COVID-19 Chronic Follicular Conjunctivitis. 61
33604091 2021
8
[Pathogenetic and clinical aspects of floppy eyelid syndrome]. 61
33610157 2021
9
Is oxidative stress involved in vernal keratoconjunctivitis? Results from a pilot study in children. 61
33236421 2020
10
Complicated case of Mycobacterium abscessus conjunctivitis in Sjögren's syndrome. 61
32548334 2020
11
High throughput sequencing reveals high specificity of TNFAIP3 mutations in ocular adnexal marginal zone B-cell lymphomas. 61
32012328 2020
12
Punctal Congestion Syndrome: A Reversible, Functional Punctal Stenosis Causing Epiphora in the Setting of Chronic Pretarsal Conjunctivitis. 61
32890120 2020
13
Milestones in the fight to eliminate trachoma. 61
32017172 2020
14
Chronic Conjunctivitis From a Retained Contact Lens. 61
30724838 2020
15
Dry Eyes Status on Des Scale and Related Factors in Outpatients at Vietnam National Institute of Ophthalmology. 61
32215080 2019
16
Chronic Conjunctivitis in an Older Patient With Ptosis. 61
31725837 2019
17
Chronic conjunctivitis as a prognosis factor of dacryocystorhinostomy: a retrospective case-controlled study. 61
31358137 2019
18
Molecular Detection of Chlamydia felis in Cats in Ahvaz, Iran. 61
31232561 2019
19
Exclusively ocular and cardiac manifestation of granulomatosis with polyangiitis - a case report. 61
31253129 2019
20
Ocular Cicatricial Pemphigoid: Camouflaged as Persistent Conjunctivitis. 61
31142415 2019
21
Brimonidine-induced unilateral ocular lichen planus: a case report. 61
30916215 2019
22
Outcome of External Dacryocystorhinostomy and Monocanalicular Intubation in Patients with Total Obstruction of One Canalicus. 61
30977323 2019
23
Granulomatous Uveitis and Conjunctivitis Due to Common Variable Immune Deficiency: A Case Report. 61
30142001 2019
24
Sleep Disorders are a Prevalent and Serious Comorbidity in Dry Eye. 61
30481819 2018
25
Clinical, histopathological, and genetic aspects in one case of ligneous conjunctivitis. 61
30058940 2018
26
Feline Herpesvirus 1 US3 Blocks the Type I Interferon Signal Pathway by Targeting Interferon Regulatory Factor 3 Dimerization in a Kinase-Independent Manner. 61
29618645 2018
27
Pediatric self-inflicted eye trauma due to a major depressive disorder. 61
29997760 2018
28
Primary Conjunctiva Tuberculosis and Review of Literature. 61
33601773 2018
29
Management of patients with ocular manifestations in vesiculobullous disorders affecting the mouth. 61
27717107 2017
30
Eyelid Molluscum Contagiosum Lesions in Two Patients with Unilateral Chronic Conjunctivitis. 61
28845328 2017
31
Clinical efficacy of nutraceutical diet for cats with clinical signs of cutaneus adverse food reaction (CAFR). 61
28865210 2017
32
Sensitization from ketotifen fumarate in eye drops presenting as chronic conjunctivitis. 61
28095628 2017
33
Pediatric conjunctival lymphoma associated with oral carbamazepine use. 61
29503903 2016
34
Successful Treatment with Chronic Conjunctivitis: Removal of Tarsoconjunctival Crypt. 61
27478360 2016
35
Chronic tarsal conjunctivitis. 61
27473439 2016
36
Stevens-Johnson syndrome: The role of an ophthalmologist. 61
26829569 2016
37
Keratoconjunctivitis sicca exacerbation in a dog treated with systemic atenolol. 61
27071733 2016
38
Sleep and mood disorders in dry eye disease and allied irritating ocular diseases. 61
26927330 2016
39
Primary conjunctival follicular lymphoma mimicking chronic conjunctivitis. 61
26560164 2016
40
Clinical features and in vivo confocal microscopy assessment in 12 patients with ocular cicatricial pemphigoid. 61
27275431 2016
41
Canaliculitis Awareness. 61
27800254 2016
42
Contact Lens Use in Patients With Boston Keratoprosthesis Type 1: Fitting, Management, and Complications. 61
26020487 2015
43
Chronic Conjunctivitis due to Nocardia nova Complex Formation on a Silicone Stent: A Case Report and Review of the Literature. 61
24892274 2015
44
Chronic Conjunctivitis and "Warts". 61
26180942 2015
45
Sarcoidosis Presenting with Cicatrizing Conjunctivitis. 61
26099057 2015
46
Systemic amyloidosis with bilateral conjunctival involvement: a case report. 61
26189153 2015
47
IgG4-related Disease Masquerading as Recurrent Scleritis and Chronic Conjunctivitis. 61
25548981 2015
48
Characteristics of the bacterial flora in the conjunctival sac of cats from Poland. 61
25482666 2015
49
Further spreading of canine oriental eyeworm in Europe: first report of Thelazia callipaeda in Romania. 61
25623605 2015
50
A novel case of chronic conjunctivitis in a 58-year-old woman caused by Raoultella. 61
24865691 2014

Variations for Chronic Conjunctivitis

Expression for Chronic Conjunctivitis

Search GEO for disease gene expression data for Chronic Conjunctivitis.

Pathways for Chronic Conjunctivitis

Pathways related to Chronic Conjunctivitis according to GeneCards Suite gene sharing:

(show all 50)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.06 TNFSF4 TNF RNASE3 MUC5AC IL6 IL5
2
Show member pathways
13.87 TNFSF4 TNF IL6 IL5 IL4 IL13
3
Show member pathways
13.71 TSLP TNFSF4 TNF IL6 IL5 IL4
4
Show member pathways
13.58 TNF IL6 IL5 IL4 IL13 IL10
5
Show member pathways
13.5 TNFSF4 TNF IL6 IL5 IL4 IL13
6
Show member pathways
13.4 TNFSF4 TNF IL6 IL5 IL4 IL33
7
Show member pathways
13.39 TNFSF4 TNF IL6 IL5 IL4 IL13
8
Show member pathways
12.89 TNF RNASE3 IL6 IL5 IL4 IL13
9
Show member pathways
12.82 TNF IL6 IL33 FCER2 CXCL8
10
Show member pathways
12.71 TNF IL4 IL10 IGHE ICOSLG CD4
11
Show member pathways
12.7 TNF IL6 IL5 IL4 IL13 IL10
12
Show member pathways
12.67 TNF IL6 IL5 IL4 IL10 CD4
13
Show member pathways
12.63 TNF IL5 IL4 IL13 IGHE
14
Show member pathways
12.55 TSLP IL6 IL5 IL4 IL13 IL10
15
Show member pathways
12.47 IL4 IGHE HRH1 FCER2 CCL11
16
Show member pathways
12.46 TNF MUC5AC IL6 IL5 IL4 IL13
17
Show member pathways
12.44 TNF IL6 IL10 CXCL8 CCR6 CCL11
18
Show member pathways
12.37 TNF IL6 IL5 IL4 IL13 IL10
19
Show member pathways
12.3 TNF MUC5AC IL6 IL33 CXCL8
20
Show member pathways
12.27 TNF IL6 IL4 CXCL8 CCL11
21 12.25 TNF IL6 IL13 IL10 CXCL8
22 12.17 TNF IL6 IL10 CXCL8 CD4
23 12.14 TNF IL6 IL5 IL4 IL10 CD4
24 12.07 TNF IL6 IL4 CXCL8
25 12.04 TNF IL6 IL5 IL4 FCER2 CD4
26 12 TNF IL6 IL10 CXCL8
27 11.94 IL6 IL5 IL4 IL13 CXCL8
28 11.87 TNF IL6 IL4 IL13 IL10 IGHE
29
Show member pathways
11.86 TNF IL6 IL10 CD4
30 11.85 TNF IL6 IL10 CXCL8
31
Show member pathways
11.85 TNF IL5 IL4 CXCL8
32 11.84 TNF IL6 IL10 CD4
33 11.82 IL5 IL4 IL10 IGHE FCER2 CCL11
34 11.82 TNF IL6 IL5 IL4 IL10 ICOSLG
35 11.78 TNF IL6 IL5 IL4 IL13 CXCL8
36
Show member pathways
11.68 TNF IL6 CXCL8
37 11.66 TSLP TNFSF4 IL6 CXCL8 CRLF2 CCL11
38 11.64 TNF IL6 IL10 CXCL8
39 11.63 TNF IL6 CXCL8
40 11.6 TNF IL6 IL4 IL13 IL10 FCER2
41 11.44 TNF IL6 IL10
42 11.42 TNF IL6 IL10
43 11.37 TNFSF4 IL5 IL4 IL13 IL10
44 11.37 TSLP TNF IL6 IL5 IL4 IL33
45 11.27 TNFSF4 IL5 IL4 IL33 IL13 IL10
46 11.26 TNF IL6 IL5 IL4 IL13 IL10
47 11.23 TSLP TNF IL5 IL4 IL33 IL13
48 11.14 TNF IL6 CXCL8
49 11.13 TNFSF4 TNF IL6 IL5 IL4 IL13
50 10.97 IL6 IL5 IL4 IL13

GO Terms for Chronic Conjunctivitis

Cellular components related to Chronic Conjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.77 TSLP TNFSF4 TNF RNASE3 MUC5AC IL6
2 external side of plasma membrane GO:0009897 9.76 TNF IL13 IGHE ICOSLG FCER2 CRLF2
3 extracellular region GO:0005576 9.5 TSLP TNF RNASE3 MUC5AC IL6 IL5

Biological processes related to Chronic Conjunctivitis according to GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.21 TSLP TNFSF4 IL6 IL5 IL4 IL10
2 positive regulation of transcription, DNA-templated GO:0045893 10.16 TNF IL6 IL5 IL4 IL10 CD4
3 positive regulation of cell proliferation GO:0008284 10.11 TSLP TNFSF4 IL6 IL5 IL4 CRLF2
4 positive regulation of gene expression GO:0010628 10.09 TNF IL6 IL4 IL33 IL13 CXCL8
5 cellular response to lipopolysaccharide GO:0071222 9.97 TNFSF4 TNF IL6 IL10 CXCL8
6 inflammatory response GO:0006954 9.97 TNFSF4 TNF IL6 IL5 IL13 HRH1
7 chemotaxis GO:0006935 9.96 RNASE3 CXCL8 CCR6 CCL11
8 positive regulation of DNA-binding transcription factor activity GO:0051091 9.91 TNF IL6 IL5 IL10
9 positive regulation of inflammatory response GO:0050729 9.9 TSLP TNFSF4 TNF IL33
10 defense response to Gram-negative bacterium GO:0050829 9.89 TSLP RNASE3 IL6 CD4
11 chemokine-mediated signaling pathway GO:0070098 9.88 CXCL8 CCR6 CCL11
12 antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 9.88 TSLP RNASE3 CXCL8
13 positive regulation of T cell proliferation GO:0042102 9.88 TNFSF4 IL6 IL4 CD4
14 response to glucocorticoid GO:0051384 9.87 TNF IL6 IL10
15 positive regulation of smooth muscle cell proliferation GO:0048661 9.87 TNF IL6 IL13
16 humoral immune response GO:0006959 9.86 TNF IL6 CCR6
17 positive regulation of cytokine production GO:0001819 9.85 TNFSF4 TNF IL33 IL10
18 positive regulation of interleukin-6 production GO:0032755 9.85 TSLP TNFSF4 TNF IL6 IL33
19 T cell activation GO:0042110 9.83 IL4 ICOSLG CD4
20 negative regulation of interferon-gamma production GO:0032689 9.83 TNFSF4 IL33 IL10
21 positive regulation of B cell proliferation GO:0030890 9.82 IL5 IL4 IL13
22 negative regulation of endothelial cell apoptotic process GO:2000352 9.82 IL4 IL13 IL10
23 positive regulation of chemokine production GO:0032722 9.81 TSLP TNF IL6 IL33
24 microglial cell activation GO:0001774 9.8 TNF IL4 IL13
25 positive regulation of JAK-STAT cascade GO:0046427 9.8 TNF IL6 IL5 IL10
26 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.8 TSLP TNF IL6 IL4 IL13
27 negative regulation of neurogenesis GO:0050768 9.78 TNF IL6 CCL11
28 positive regulation of macrophage activation GO:0043032 9.76 IL33 IL13 IL10
29 positive regulation of neuroinflammatory response GO:0150078 9.73 TNF IL6 IL33
30 immune response GO:0006955 9.73 TNFSF4 TNF IL6 IL5 IL4 IL13
31 positive regulation of podosome assembly GO:0071803 9.71 TNF IL5
32 response to molecule of bacterial origin GO:0002237 9.71 IL10 CXCL8
33 positive regulation of MHC class II biosynthetic process GO:0045348 9.71 IL4 IL33 IL10
34 positive regulation of mast cell degranulation GO:0043306 9.7 IL4 IL13
35 negative regulation of lipid storage GO:0010888 9.7 TNF IL6
36 positive regulation of interleukin-5 production GO:0032754 9.7 TSLP IL33 CRLF2
37 endothelial cell apoptotic process GO:0072577 9.69 TNF IL10
38 vascular endothelial growth factor production GO:0010573 9.69 TNF IL6
39 positive regulation of mononuclear cell migration GO:0071677 9.68 TNF IL4
40 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 9.68 TNF FCER2
41 positive regulation of type 2 immune response GO:0002830 9.67 TNFSF4 IL33
42 negative regulation of cytokine production involved in immune response GO:0002719 9.67 TNF IL10
43 type 2 immune response GO:0042092 9.67 IL4 IL10
44 positive regulation of mast cell activation GO:0033005 9.66 TSLP CRLF2
45 positive regulation of STAT cascade GO:1904894 9.65 TSLP IL6 CRLF2
46 positive regulation of interleukin-10 production GO:0032733 9.65 TSLP TNFSF4 IL6 IL4 IL13
47 negative regulation of complement-dependent cytotoxicity GO:1903660 9.63 IL4 IL13
48 regulation of isotype switching GO:0045191 9.63 IL4 IL10
49 positive regulation of immunoglobulin production GO:0002639 9.63 TNFSF4 IL6 IL5 IL33 IL13 IL10
50 positive regulation of interleukin-13 production GO:0032736 9.62 TSLP TNFSF4 IL4 IL33

Molecular functions related to Chronic Conjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.36 TSLP TNFSF4 TNF IL6 IL5 IL4
2 growth factor activity GO:0008083 9.26 IL6 IL5 IL4 IL10

Sources for Chronic Conjunctivitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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