MCID: CHR086
MIFTS: 38

Chronic Conjunctivitis

Categories: Eye diseases

Aliases & Classifications for Chronic Conjunctivitis

MalaCards integrated aliases for Chronic Conjunctivitis:

Name: Chronic Conjunctivitis 12 55 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:2475
ICD10 33 H10.4 H10.40
ICD9CM 35 372.1 372.10
NCIt 50 C35197
UMLS 73 C0155145

Summaries for Chronic Conjunctivitis

MalaCards based summary : Chronic Conjunctivitis is related to allergic conjunctivitis and scleritis. An important gene associated with Chronic Conjunctivitis is FCER2 (Fc Fragment Of IgE Receptor II), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Iodine and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include eye and thyroid, and related phenotypes are hematopoietic system and immune system

Related Diseases for Chronic Conjunctivitis

Diseases in the Conjunctivitis family:

Acute Conjunctivitis Chronic Conjunctivitis
Bacterial Conjunctivitis

Diseases related to Chronic Conjunctivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 124)
# Related Disease Score Top Affiliating Genes
1 allergic conjunctivitis 30.7 CCL11 IL13 IL4 IL5 RNASE3
2 scleritis 30.1 IL4 IL5
3 conjunctivitis 30.0 CCL11 IL13 IL4 IL5 RNASE3
4 ocular cicatricial pemphigoid 29.4 IL4 RNASE3
5 dermatitis 26.9 CCL11 CMA1 IL13 IL4 IL5 RNASE3
6 asthma 26.6 CCL11 CCL5 FCER2 IL13 IL4 IL5
7 dermatitis, atopic 25.6 CCL11 CCL5 CMA1 FCER2 IL13 IL4
8 simple chronic conjunctivitis 12.0
9 ligneous conjunctivitis 10.8
10 persistent polyclonal b-cell lymphocytosis 10.7 FCER2 IL4
11 pemphigoid gestationis 10.6 CCL11 IL5
12 papillary conjunctivitis 10.6 CCL11 IL4
13 cytokine deficiency 10.6 IL13 IL5
14 chronic meningitis 10.6 CCL11 IL5
15 loeffler endocarditis 10.6 IL5 RNASE3
16 penicillin allergy 10.6 IL13 IL4
17 angioimmunoblastic lymphadenopathy with dysproteinemia 10.6 IL13 IL5
18 blepharitis 10.6 CCL11 IL4
19 cow milk allergy 10.6 IL5 RNASE3
20 beta-lactam allergy 10.5 IL13 IL4
21 egg allergy 10.5 IL4 IL5
22 trichinosis 10.5 IL4 IL5
23 cellulitis 10.5 IL5 RNASE3
24 non-suppurative otitis media 10.5 IL4 IL5
25 sinusitis 10.5 IL5 RNASE3
26 primary amebic meningoencephalitis 10.4 IL4 IL5
27 vulvovaginitis 10.4 CCL11 CCL5
28 maxillary sinusitis 10.4 CCL5 RNASE3
29 african tick-bite fever 10.4 CCL5 IL13
30 giant papillary conjunctivitis 10.4 CCL11 IL4 RNASE3
31 eosinophilic gastroenteritis 10.4 CCL11 IL5 RNASE3
32 strongyloidiasis 10.3 CCL11 IL13 IL5
33 paragonimiasis 10.3 IL13 IL5 RNASE3
34 bronchitis 10.3 CCL11 IL5 RNASE3
35 wells syndrome 10.3 IL5 RNASE3
36 night blindness, congenital stationary, type 1a 10.3 CCL11 IL13 IL5
37 toxic oil syndrome 10.3 FCER2 IL4 IL5
38 cough variant asthma 10.3 IL4 IL5 RNASE3
39 bullous pemphigoid 10.3 CCL11 IL5 RNASE3
40 allergic bronchopulmonary aspergillosis 10.3 IL4 IL5
41 pollen allergy 10.3 IL13 IL5 RNASE3
42 atopic keratoconjunctivitis 10.3 IL4 IL5 RNASE3
43 cold urticaria 10.3 CMA1 RNASE3
44 churg-strauss syndrome 10.3 IL5 RNASE3
45 apple allergy 10.3 IL13 IL4 IL5
46 milk allergy 10.3 IL4 IL5 RNASE3
47 intestinal schistosomiasis 10.3 IL13 IL4 IL5
48 chronic tic disorder 10.2 IL13 IL4 IL5
49 orofacial granulomatosis 10.2 CCL5 IL4
50 enterobiasis 10.2 IL13 IL4 IL5

Comorbidity relations with Chronic Conjunctivitis via Phenotypic Disease Network (PDN):


Acute Cystitis Heart Disease

Graphical network of the top 20 diseases related to Chronic Conjunctivitis:



Diseases related to Chronic Conjunctivitis

Symptoms & Phenotypes for Chronic Conjunctivitis

MGI Mouse Phenotypes related to Chronic Conjunctivitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.61 CCL11 CCL5 CMA1 FCER2 IL13 IL4
2 immune system MP:0005387 9.32 CCL11 CCL5 CMA1 FCER2 IL13 IL4

Drugs & Therapeutics for Chronic Conjunctivitis

Drugs for Chronic Conjunctivitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iodine Approved, Investigational Not Applicable 7553-56-2 807
2 Anti-Infective Agents Not Applicable
3 Anti-Infective Agents, Local Not Applicable
4 cadexomer iodine Not Applicable
5 Micronutrients Not Applicable
6 Trace Elements Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Lacrimal Drainage System Obstruction Associated to Radioactive Iodine Therapy for Thyroid Carcinoma Unknown status NCT01579344 Not Applicable Radioiodine therapy
2 Investigation of Chronic Inflammatory Processes in Male Individuals With Hypohidrotic Ectodermal Dysplasia Completed NCT01308333

Search NIH Clinical Center for Chronic Conjunctivitis

Genetic Tests for Chronic Conjunctivitis

Anatomical Context for Chronic Conjunctivitis

MalaCards organs/tissues related to Chronic Conjunctivitis:

41
Eye, Thyroid

Publications for Chronic Conjunctivitis

Articles related to Chronic Conjunctivitis:

(show top 50) (show all 51)
# Title Authors Year
1
Eyelid Molluscum Contagiosum Lesions in Two Patients with Unilateral Chronic Conjunctivitis. ( 28845328 )
2017
2
Sensitization from ketotifen fumarate in eye drops presenting as chronic conjunctivitis. ( 28095628 )
2017
3
Successful Treatment with Chronic Conjunctivitis: Removal of Tarsoconjunctival Crypt. ( 27478360 )
2016
4
Primary conjunctival follicular lymphoma mimicking chronic conjunctivitis. ( 26560164 )
2015
5
Chronic Conjunctivitis and "Warts". ( 26180942 )
2015
6
IgG4-related Disease Masquerading as Recurrent Scleritis and Chronic Conjunctivitis. ( 25548981 )
2015
7
A 37-year-old man referred for assistance with persistent asthma, atopic dermatitis, and chronic conjunctivitis. ( 24679732 )
2014
8
Chronic Conjunctivitis due to Nocardia nova Complex Formation on a Silicone Stent: A Case Report and Review of the Literature. ( 24892274 )
2014
9
A novel case of chronic conjunctivitis in a 58-year-old woman caused by Raoultella. ( 24865691 )
2014
10
Insight into behavior of epithelial cells of the feline conjunctiva in chronic conjunctivitis as a possible limitation in detection of Chlamydophila spp. ( 25286651 )
2014
11
Methicillin-resistant Staphylococcus aureus with the novel mecC gene variant isolated from a cat suffering from chronic conjunctivitis. ( 23212114 )
2013
12
Chronic conjunctivitis due to Mycobacterium tuberculosis. ( 23928944 )
2013
13
Antibiotic susceptibility of staphylococci isolates from patients with chronic conjunctivitis: including associated factors and clinical evaluation. ( 23944906 )
2013
14
Chronic conjunctivitis related to phthiriasis palpebrarum. ( 22707338 )
2012
15
Ocular cicatricial pemphigoid masquerading as chronic conjunctivitis: a case report. ( 23269857 )
2012
16
Real-time PCR detection of Mycoplasma felis in domestic cats suffering from chronic conjunctivitis (Poland). ( 22439345 )
2011
17
Feline herpesvirus 1 and Chlamydophila felis prevalence in cats with chronic conjunctivitis. ( 20731196 )
2010
18
Bilateral conjunctival MALT lymphoma mimicking chronic conjunctivitis. ( 20523096 )
2010
19
A Case of Chronic Conjunctivitis following Rituximab Therapy. ( 19946424 )
2009
20
Chronic conjunctivitis in a patient with folic acid deficiency. ( 17651461 )
2007
21
Chronic conjunctivitis in a patient with folic acid deficiency. ( 17305744 )
2007
22
Isolated chronic conjunctivitis due to storage mite allergy. ( 16729793 )
2006
23
Vasomotor (perennial chronic) conjunctivitis. ( 16954789 )
2006
24
Obliterative microangiopathy presenting as chronic conjunctivitis in a patient with relapsing polychondritis. ( 16783155 )
2006
25
Prevalence of trachoma in chronic conjunctivitis, Birjand, Islamic Republic of Iran. ( 15339124 )
2002
26
Chronic conjunctivitis due to lacrimal system blockage relieved by dacryocystorhinostomy. ( 11116711 )
2000
27
Correlation between tear IgE levels and HLA-DR expression by conjunctival cells in allergic and nonallergic chronic conjunctivitis. ( 11148813 )
2000
28
[Measurement of total IgE in tears : the adaptation of an immunoenzyme technique and the value of investigating locally produced IgE in the diagnosis of chronic conjunctivitis]. ( 10432371 )
1999
29
Conjunctival lymphoma masquerading as chronic conjunctivitis. ( 10201599 )
1999
30
[Value of lacrymal IgE determination and conjunctival cytology in the diagnosis of chronic conjunctivitis]. ( 9759406 )
1998
31
Conjunctival scrapings and impression cytology in chronic conjunctivitis. Correlation with microbiology. ( 9101190 )
1997
32
Acute and chronic conjunctivitis due to over-the-counter ophthalmic decongestants. ( 9006422 )
1997
33
Bilateral chronic conjunctivitis and corneal scarring in a boy with X-linked hypogammaglobulinaemia. ( 8933411 )
1996
34
Clinical and laboratory findings in chronic conjunctivitis in cats: 91 cases (1983-1991). ( 8226238 )
1993
35
Chronic conjunctivitis in infants and children. ( 8414690 )
1993
36
Chronic conjunctivitis caused by oral anaerobes and effectively treated with systemic metronidazole plus amoxicillin. ( 1890173 )
1991
37
A systemic approach to the diagnosis of chronic conjunctivitis. ( 2378391 )
1990
38
A systematic approach to the diagnosis and treatment of chronic conjunctivitis. ( 2154106 )
1990
39
Tear film flow and stability in acute and chronic conjunctivitis. ( 3618153 )
1987
40
A double-blind crossover study comparing sodium cromoglycate eye drops with placebo in the treatment of chronic conjunctivitis. ( 6431741 )
1984
41
Chronic conjunctivitis associated with 'floppy eyelids'. ( 6651592 )
1983
42
Laboratory studies in chronic conjunctivitis. ( 6660697 )
1983
43
Clinical trial of the topical use of disodium cromoglycate in vernal, allergic and chronic conjunctivitis. ( 6773293 )
1980
44
Development of chronic conjunctivitis with scarring and pannus, resembling trachoma, in guinea-pigs. ( 7387962 )
1980
45
Observations on conjunctival neoplasms masquerading as chronic conjunctivitis or keratitis. ( 5357353 )
1969
46
Conjunctival carcinoma masquerading as chronic conjunctivitis. ( 6064087 )
1967
47
Chronic conjunctivitis. ( 5602921 )
1967
48
The importance of a polarization microscope in a case of chronic conjunctivitis. ( 5849034 )
1965
49
CHRONIC CONJUNCTIVITIS. ( 14047012 )
1963
50
Paredrine hydrobromide in chronic conjunctivitis. ( 12996629 )
1952

Variations for Chronic Conjunctivitis

Expression for Chronic Conjunctivitis

Search GEO for disease gene expression data for Chronic Conjunctivitis.

Pathways for Chronic Conjunctivitis

Pathways related to Chronic Conjunctivitis according to GeneCards Suite gene sharing:

(show all 23)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.82 CCL11 CCL5 DDX41 FCER2 IL13 IL4
2
Show member pathways
13.45 CCL11 CCL5 FCER2 IL13 IL4 IL5
3
Show member pathways
13.22 CCL11 CCL5 IL13 IL4 IL5 TNFSF4
4
Show member pathways
13.15 CCL11 CCL5 FCER2 IL13 IL4 IL5
5
Show member pathways
13.09 CCL11 CCL5 IL13 IL4 IL5 TNFSF4
6
Show member pathways
12.7 CCL11 IL13 IL4 IL5 RNASE3
7 12.63 IL13 IL4 IL5 PTGER3
8
Show member pathways
12.48 IL13 IL4 IL5 TSLP
9
Show member pathways
12.17 CCL11 IL13 IL4 IL5
10
Show member pathways
11.89 CCL11 CCL5 IL13 IL4 IL5
11 11.79 CCL11 FCER2 IL13 IL4
12 11.75 FCER2 IL4 IL5
13 11.66 IL13 IL4 IL5
14 11.61 IL13 IL4 IL5 TSLP
15 11.47 CCL11 FCER2 IL4 IL5
16 11.37 CCL11 TNFSF4 TSLP
17 11.31 CCL5 FCER2 IL13 IL4
18 11.13 IL4 IL5
19 11.11 IL13 IL4 IL5
20 11.06 IL13 IL4 IL5 TSLP
21 11.02 CCL11 IL13 IL4 IL5 TNFSF4
22 10.9 CCL11 CCL5 CMA1 IL13 IL4 IL5
23 10.87 IL13 IL4 IL5 TNFSF4

GO Terms for Chronic Conjunctivitis

Cellular components related to Chronic Conjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 CCL11 CCL5 CMA1 FCER2 IL13 IL4
2 extracellular space GO:0005615 9.28 CCL11 CCL5 CMA1 IL13 IL4 IL5

Biological processes related to Chronic Conjunctivitis according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.8 CCL11 CCL5 IL13 IL5 PTGER3 TNFSF4
2 response to virus GO:0009615 9.67 CCL11 CCL5 TNFSF4
3 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.63 CCL5 IL13 TSLP
4 cytokine-mediated signaling pathway GO:0019221 9.63 CCL11 CCL5 FCER2 IL13 IL4 IL5
5 positive regulation of T cell proliferation GO:0042102 9.61 CCL5 IL4 TNFSF4
6 positive regulation of B cell proliferation GO:0030890 9.58 IL13 IL4 IL5
7 negative regulation of endothelial cell apoptotic process GO:2000352 9.56 IL13 IL4
8 lymphocyte chemotaxis GO:0048247 9.55 CCL11 CCL5
9 positive regulation of JAK-STAT cascade GO:0046427 9.54 CCL5 IL5
10 eosinophil chemotaxis GO:0048245 9.52 CCL11 CCL5
11 positive regulation of interleukin-10 production GO:0032733 9.51 TNFSF4 TSLP
12 immune response GO:0006955 9.5 CCL11 CCL5 CMA1 IL13 IL4 IL5
13 positive regulation of immunoglobulin secretion GO:0051024 9.48 IL5 TNFSF4
14 positive regulation of interleukin-13 production GO:0032736 9.43 IL4 TNFSF4 TSLP
15 negative regulation of complement-dependent cytotoxicity GO:1903660 9.37 IL13 IL4
16 regulation of signaling receptor activity GO:0010469 9.17 CCL11 CCL5 IL13 IL4 IL5 TNFSF4

Molecular functions related to Chronic Conjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.17 CCL11 CCL5 IL13 IL4 IL5 TNFSF4
2 CCR chemokine receptor binding GO:0048020 9.16 CCL11 CCL5
3 cytokine receptor binding GO:0005126 8.96 IL13 IL4

Sources for Chronic Conjunctivitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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