MCID: CHR086
MIFTS: 38

Chronic Conjunctivitis

Categories: Eye diseases, Immune diseases

Aliases & Classifications for Chronic Conjunctivitis

MalaCards integrated aliases for Chronic Conjunctivitis:

Name: Chronic Conjunctivitis 12 56 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:2475
ICD9CM 36 372.1 372.10
NCIt 51 C35197
SNOMED-CT 69 73762008
ICD10 34 H10.4 H10.40
UMLS 74 C0155145

Summaries for Chronic Conjunctivitis

MalaCards based summary : Chronic Conjunctivitis is related to allergic conjunctivitis and conjunctivitis. An important gene associated with Chronic Conjunctivitis is FCER2 (Fc Fragment Of IgE Receptor II), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Iodine and Anti-Infective Agents, Local have been mentioned in the context of this disorder. Affiliated tissues include eye and thyroid, and related phenotypes are hematopoietic system and immune system

Related Diseases for Chronic Conjunctivitis

Diseases in the Conjunctivitis family:

Acute Conjunctivitis Chronic Conjunctivitis
Bacterial Conjunctivitis

Diseases related to Chronic Conjunctivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 125)
# Related Disease Score Top Affiliating Genes
1 allergic conjunctivitis 31.1 CCL11 IL13 IL4 IL5 RNASE3
2 conjunctivitis 30.5 CCL11 IL13 IL4 IL5 RNASE3
3 scleritis 29.8 IL4 IL5
4 ocular cicatricial pemphigoid 29.6 IL4 RNASE3
5 dermatitis 28.3 CCL11 CMA1 IL13 IL4 IL5 TSLP
6 asthma 28.0 CCL11 CCL5 FCER2 IL13 IL4 IL5
7 dermatitis, atopic 27.3 CCL11 CCL5 CMA1 FCER2 IL13 IL4
8 simple chronic conjunctivitis 12.2
9 ligneous conjunctivitis 11.0
10 papillary conjunctivitis 10.3 CCL11 IL4
11 persistent polyclonal b-cell lymphocytosis 10.3 FCER2 IL4
12 loeffler endocarditis 10.3 IL5 RNASE3
13 cytokine deficiency 10.3 IL13 IL5
14 pemphigoid gestationis 10.3 CCL11 IL5
15 penicillin allergy 10.3 IL13 IL4
16 cow milk allergy 10.3 IL5 RNASE3
17 plasminogen deficiency, type i 10.3
18 chronic meningitis 10.3 CCL11 IL5
19 angioimmunoblastic lymphadenopathy with dysproteinemia 10.3 IL13 IL5
20 sinusitis 10.3 IL5 RNASE3
21 beta-lactam allergy 10.2 IL13 IL4
22 egg allergy 10.2 IL4 IL5
23 sulfamethoxazole allergy 10.2 IL4 IL5
24 mycoplasma pneumoniae pneumonia 10.2 IL13 IL4
25 trichinosis 10.2 IL4 IL5
26 gaucher disease, type ii 10.2 IL4 IL5
27 giant papillary conjunctivitis 10.2 CCL11 IL4 RNASE3
28 non-suppurative otitis media 10.2 IL4 IL5
29 filarial elephantiasis 10.2 IL4 IL5
30 paragonimiasis 10.1 IL13 IL5 RNASE3
31 vulvovaginitis 10.1 CCL11 CCL5
32 otitis media 10.1 CCL11 IL4 RNASE3
33 wells syndrome 10.1 IL5 RNASE3
34 maxillary sinusitis 10.1 CCL5 RNASE3
35 african tick-bite fever 10.1 CCL5 IL13
36 pollen allergy 10.1 IL13 IL5 RNASE3
37 strongyloidiasis 10.1 CCL11 IL13 IL5
38 bronchitis 10.1 CCL11 IL5 RNASE3
39 radiculopathy 10.1 CCL11 IL13 IL5
40 churg-strauss syndrome 10.1 IL5 RNASE3
41 allergic bronchopulmonary aspergillosis 10.1 IL4 IL5
42 bullous pemphigoid 10.1 CCL11 IL5 RNASE3
43 night blindness, congenital stationary, type 1a 10.1 CCL11 IL13 IL5
44 cough variant asthma 10.1 IL4 IL5 RNASE3
45 toxic oil syndrome 10.1 FCER2 IL4 IL5
46 atopic keratoconjunctivitis 10.1 IL4 IL5 RNASE3
47 leishmaniasis 10.1 IL13 IL4 IL5
48 milk allergy 10.1 IL4 IL5 RNASE3
49 nickel allergic contact dermatitis 10.1 IL13 IL4 IL5
50 apple allergy 10.1 IL13 IL4 IL5

Comorbidity relations with Chronic Conjunctivitis via Phenotypic Disease Network (PDN):


Acute Cystitis Heart Disease

Graphical network of the top 20 diseases related to Chronic Conjunctivitis:



Diseases related to Chronic Conjunctivitis

Symptoms & Phenotypes for Chronic Conjunctivitis

MGI Mouse Phenotypes related to Chronic Conjunctivitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.61 CCL11 CCL5 CMA1 FCER2 IL13 IL4
2 immune system MP:0005387 9.32 CCL11 CCL5 CMA1 FCER2 IL13 IL4

Drugs & Therapeutics for Chronic Conjunctivitis

Drugs for Chronic Conjunctivitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iodine Approved, Investigational Not Applicable 7553-56-2 807
2 Anti-Infective Agents, Local Not Applicable
3 cadexomer iodine Not Applicable
4 Nutrients Not Applicable
5 Anti-Infective Agents Not Applicable
6 Trace Elements Not Applicable
7 Micronutrients Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Lacrimal Drainage System Obstruction Associated to Radioactive Iodine Therapy for Thyroid Carcinoma Unknown status NCT01579344 Not Applicable Radioiodine therapy
2 Investigation of Chronic Inflammatory Processes in Male Individuals With Hypohidrotic Ectodermal Dysplasia Completed NCT01308333

Search NIH Clinical Center for Chronic Conjunctivitis

Genetic Tests for Chronic Conjunctivitis

Anatomical Context for Chronic Conjunctivitis

MalaCards organs/tissues related to Chronic Conjunctivitis:

42
Eye, Thyroid

Publications for Chronic Conjunctivitis

Articles related to Chronic Conjunctivitis:

(show top 50) (show all 53)
# Title Authors Year
1
Chronic Conjunctivitis From a Retained Contact Lens. ( 30724838 )
2019
2
Eyelid Molluscum Contagiosum Lesions in Two Patients with Unilateral Chronic Conjunctivitis. ( 28845328 )
2017
3
Sensitization from ketotifen fumarate in eye drops presenting as chronic conjunctivitis. ( 28095628 )
2017
4
Successful Treatment with Chronic Conjunctivitis: Removal of Tarsoconjunctival Crypt. ( 27478360 )
2016
5
Primary conjunctival follicular lymphoma mimicking chronic conjunctivitis. ( 26560164 )
2015
6
Chronic Conjunctivitis and "Warts". ( 26180942 )
2015
7
IgG4-related Disease Masquerading as Recurrent Scleritis and Chronic Conjunctivitis. ( 25548981 )
2015
8
A 37-year-old man referred for assistance with persistent asthma, atopic dermatitis, and chronic conjunctivitis. ( 24679732 )
2014
9
Chronic Conjunctivitis due to Nocardia nova Complex Formation on a Silicone Stent: A Case Report and Review of the Literature. ( 24892274 )
2014
10
A novel case of chronic conjunctivitis in a 58-year-old woman caused by Raoultella. ( 24865691 )
2014
11
Insight into behavior of epithelial cells of the feline conjunctiva in chronic conjunctivitis as a possible limitation in detection of Chlamydophila spp. ( 25286651 )
2014
12
Methicillin-resistant Staphylococcus aureus with the novel mecC gene variant isolated from a cat suffering from chronic conjunctivitis. ( 23212114 )
2013
13
Chronic conjunctivitis due to Mycobacterium tuberculosis. ( 23928944 )
2013
14
Antibiotic susceptibility of staphylococci isolates from patients with chronic conjunctivitis: including associated factors and clinical evaluation. ( 23944906 )
2013
15
Chronic conjunctivitis related to phthiriasis palpebrarum. ( 22707338 )
2012
16
Ocular cicatricial pemphigoid masquerading as chronic conjunctivitis: a case report. ( 23269857 )
2012
17
Real-time PCR detection of Mycoplasma felis in domestic cats suffering from chronic conjunctivitis (Poland). ( 22439345 )
2011
18
Feline herpesvirus 1 and Chlamydophila felis prevalence in cats with chronic conjunctivitis. ( 20731196 )
2010
19
Bilateral conjunctival MALT lymphoma mimicking chronic conjunctivitis. ( 20523096 )
2010
20
A Case of Chronic Conjunctivitis following Rituximab Therapy. ( 19946424 )
2009
21
Chronic conjunctivitis in a patient with folic acid deficiency. ( 17651461 )
2007
22
Chronic conjunctivitis in a patient with folic acid deficiency. ( 17305744 )
2007
23
Isolated chronic conjunctivitis due to storage mite allergy. ( 16729793 )
2006
24
Vasomotor (perennial chronic) conjunctivitis. ( 16954789 )
2006
25
Obliterative microangiopathy presenting as chronic conjunctivitis in a patient with relapsing polychondritis. ( 16783155 )
2006
26
Prevalence of trachoma in chronic conjunctivitis, Birjand, Islamic Republic of Iran. ( 15339124 )
2002
27
Chronic conjunctivitis due to lacrimal system blockage relieved by dacryocystorhinostomy. ( 11116711 )
2000
28
Correlation between tear IgE levels and HLA-DR expression by conjunctival cells in allergic and nonallergic chronic conjunctivitis. ( 11148813 )
2000
29
[Measurement of total IgE in tears : the adaptation of an immunoenzyme technique and the value of investigating locally produced IgE in the diagnosis of chronic conjunctivitis]. ( 10432371 )
1999
30
Conjunctival lymphoma masquerading as chronic conjunctivitis. ( 10201599 )
1999
31
[Value of lacrymal IgE determination and conjunctival cytology in the diagnosis of chronic conjunctivitis]. ( 9759406 )
1998
32
Conjunctival scrapings and impression cytology in chronic conjunctivitis. Correlation with microbiology. ( 9101190 )
1997
33
Acute and chronic conjunctivitis due to over-the-counter ophthalmic decongestants. ( 9006422 )
1997
34
Bilateral chronic conjunctivitis and corneal scarring in a boy with X-linked hypogammaglobulinaemia. ( 8933411 )
1996
35
Clinical and laboratory findings in chronic conjunctivitis in cats: 91 cases (1983-1991). ( 8226238 )
1993
36
Chronic conjunctivitis in infants and children. ( 8414690 )
1993
37
Chronic conjunctivitis caused by oral anaerobes and effectively treated with systemic metronidazole plus amoxicillin. ( 1890173 )
1991
38
A systemic approach to the diagnosis of chronic conjunctivitis. ( 2378391 )
1990
39
A systematic approach to the diagnosis and treatment of chronic conjunctivitis. ( 2154106 )
1990
40
Tear film flow and stability in acute and chronic conjunctivitis. ( 3618153 )
1987
41
A double-blind crossover study comparing sodium cromoglycate eye drops with placebo in the treatment of chronic conjunctivitis. ( 6431741 )
1984
42
Chronic conjunctivitis associated with 'floppy eyelids'. ( 6651592 )
1983
43
Laboratory studies in chronic conjunctivitis. ( 6660697 )
1983
44
Clinical trial of the topical use of disodium cromoglycate in vernal, allergic and chronic conjunctivitis. ( 6773293 )
1980
45
Development of chronic conjunctivitis with scarring and pannus, resembling trachoma, in guinea-pigs. ( 7387962 )
1980
46
Observations on conjunctival neoplasms masquerading as chronic conjunctivitis or keratitis. ( 5357353 )
1969
47
Conjunctival carcinoma masquerading as chronic conjunctivitis. ( 6064087 )
1967
48
Chronic conjunctivitis. ( 5602921 )
1967
49
The importance of a polarization microscope in a case of chronic conjunctivitis. ( 5849034 )
1965
50
CHRONIC CONJUNCTIVITIS. ( 14047012 )
1963

Variations for Chronic Conjunctivitis

Expression for Chronic Conjunctivitis

Search GEO for disease gene expression data for Chronic Conjunctivitis.

Pathways for Chronic Conjunctivitis

Pathways related to Chronic Conjunctivitis according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.84 CCL11 CCL5 FCER2 ICOSLG IL13 IL4
2
Show member pathways
13.5 CCL11 CCL5 FCER2 IL13 IL4 IL5
3
Show member pathways
13.24 CCL11 CCL5 IL13 IL4 IL5 TNFSF4
4
Show member pathways
13.2 CCL11 CCL5 FCER2 IL13 IL4 IL5
5
Show member pathways
13.13 CCL11 CCL5 IL13 IL4 IL5 TNFSF4
6
Show member pathways
12.71 CCL11 ICOSLG IL13 IL4 IL5 RNASE3
7 12.65 IL13 IL4 IL5 PTGER3
8
Show member pathways
12.27 IL13 IL4 IL5 TSLP
9
Show member pathways
12.21 CCL11 IL13 IL4 IL5
10
Show member pathways
12.19 CCL11 FCER2 IL4
11
Show member pathways
11.95 CCL11 CCL5 IL13 IL4 IL5
12 11.87 CCL11 FCER2 IL13 IL4
13 11.77 FCER2 IL4 IL5
14 11.69 IL13 IL4 IL5
15 11.66 IL13 IL4 IL5 TSLP
16 11.59 CCL11 CCL5 IL13 IL4
17 11.5 CCL11 FCER2 IL4 IL5
18 11.42 CCL11 TNFSF4 TSLP
19 11.36 CCL5 FCER2 IL13 IL4
20 11.16 IL13 IL4 IL5
21 11.15 IL4 IL5
22 11.13 IL13 IL4 IL5 TSLP
23 11.02 CCL11 IL13 IL4 IL5 TNFSF4
24 10.97 IL13 IL4 IL5 TNFSF4
25 10.9 CCL11 CCL5 CMA1 IL13 IL4 IL5
26 10.86 CCL11 CCL5 IL13 IL4 IL5 TNFSF4
27 10.86 CCL11 CCL5 IL13 IL4 IL5 TNFSF4

GO Terms for Chronic Conjunctivitis

Cellular components related to Chronic Conjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 CCL11 CCL5 CMA1 FCER2 IL13 IL4
2 extracellular space GO:0005615 9.28 CCL11 CCL5 CMA1 IL13 IL4 IL5

Biological processes related to Chronic Conjunctivitis according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.85 CCL11 CCL5 IL13 IL4 IL5 TNFSF4
2 response to virus GO:0009615 9.65 CCL11 CCL5 TNFSF4
3 inflammatory response GO:0006954 9.63 CCL11 CCL5 IL13 IL5 PTGER3 TNFSF4
4 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.62 CCL5 IL13 IL4 TSLP
5 positive regulation of B cell proliferation GO:0030890 9.58 IL13 IL4 IL5
6 negative regulation of endothelial cell apoptotic process GO:2000352 9.56 IL13 IL4
7 lymphocyte chemotaxis GO:0048247 9.55 CCL11 CCL5
8 B cell activation GO:0042113 9.54 ICOSLG IL4
9 positive regulation of JAK-STAT cascade GO:0046427 9.52 CCL5 IL5
10 positive regulation of interleukin-10 production GO:0032733 9.51 TNFSF4 TSLP
11 eosinophil chemotaxis GO:0048245 9.49 CCL11 CCL5
12 positive regulation of immunoglobulin secretion GO:0051024 9.46 IL5 TNFSF4
13 negative regulation of complement-dependent cytotoxicity GO:1903660 9.43 IL13 IL4
14 positive regulation of interleukin-13 production GO:0032736 9.43 IL4 TNFSF4 TSLP
15 cytokine-mediated signaling pathway GO:0019221 9.43 CCL11 CCL5 FCER2 IL13 IL4 IL5
16 regulation of signaling receptor activity GO:0010469 9.17 CCL11 CCL5 IL13 IL4 IL5 TNFSF4

Molecular functions related to Chronic Conjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.17 CCL11 CCL5 IL13 IL4 IL5 TNFSF4
2 CCR chemokine receptor binding GO:0048020 9.16 CCL11 CCL5
3 cytokine receptor binding GO:0005126 8.96 IL13 IL4

Sources for Chronic Conjunctivitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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