MCID: CHR087
MIFTS: 34

Chronic Cystitis

Categories: Nephrological diseases

Aliases & Classifications for Chronic Cystitis

MalaCards integrated aliases for Chronic Cystitis:

Name: Chronic Cystitis 12 54 15 17 71

Classifications:



External Ids:

Disease Ontology 12 DOID:1680
ICD9CM 34 595.2
ICD10 32 N30.2
UMLS 71 C0156268 C0221763

Summaries for Chronic Cystitis

MalaCards based summary : Chronic Cystitis is related to low compliance bladder and glandular cystitis. An important gene associated with Chronic Cystitis is NGF (Nerve Growth Factor), and among its related pathways/superpathways are Spinal Cord Injury and Overview of nanoparticle effects. The drugs Anticonvulsants and Epidiolex have been mentioned in the context of this disorder. Affiliated tissues include prostate, testes and spinal cord, and related phenotype is renal/urinary system.

Related Diseases for Chronic Cystitis

Diseases in the Cystitis family:

Acute Cystitis Chronic Cystitis

Diseases related to Chronic Cystitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 210)
# Related Disease Score Top Affiliating Genes
1 low compliance bladder 30.3 P2RX3 NGF
2 glandular cystitis 30.1 UPK3A KRT7 KRT20 CDX2
3 pyuria 30.0 UPK3A NUMA1
4 hydronephrosis 29.8 UPK3A UPK2 KRT7
5 acute cystitis 29.8 UPK3A UPK1A CXCL1
6 vesicoureteral reflux 1 29.8 UPK3A UPK2 UPK1A
7 cystitis cystica 29.6 UPK2 KRT7 KRT20 CDX2
8 bladder cancer 29.1 UPK3A UPK2 UPK1A PTGS2 NUMA1 KRT20
9 transitional cell carcinoma 29.1 UPK3A UPK2 UPK1A PTGS2 KRT7 KRT20
10 interstitial cystitis 28.6 UPK3A UPK1A TRPV1 TAC1 P2RX3 NGF
11 cystitis 27.5 UPK3A UPK1A TRPV1 TAC1 PTGS2 P2RX3
12 chronic interstitial cystitis 11.3
13 renal pelvis transitional cell carcinoma 10.5 UPK3A KRT7
14 urethral villous adenoma 10.5 KRT7 KRT20
15 vulval paget's disease 10.5 UPK3A KRT7
16 nephrogenic adenoma of urinary bladder 10.5 KRT7 KRT20
17 intrahepatic bile duct adenoma 10.5 KRT7 KRT20
18 bile duct adenoma 10.5 KRT7 KRT20
19 atrophic vulva 10.5 KRT7 KRT20
20 ovary neuroendocrine neoplasm 10.5 KRT7 CDX2
21 small cell carcinoma of the bladder 10.5 KRT7 KRT20
22 anal canal paget's disease 10.5 KRT7 CDX2
23 anal paget's disease 10.5 KRT7 CDX2
24 anal gland adenocarcinoma 10.5 KRT7 CDX2
25 ureter adenocarcinoma 10.5 KRT7 CDX2
26 gastric squamous cell carcinoma 10.5 UPK3A KRT7
27 pancreatic serous cystadenocarcinoma 10.5 KRT7 KRT20
28 pancreatic foamy gland adenocarcinoma 10.5 KRT7 CDX2
29 urinary bladder small cell neuroendocrine carcinoma 10.5 KRT7 KRT20
30 adenosquamous colon carcinoma 10.5 KRT7 CDX2
31 vulvar apocrine adenocarcinoma 10.5 KRT7 KRT20
32 eyelid carcinoma 10.5 KRT7 KRT20
33 nasal cavity adenocarcinoma 10.5 KRT7 CDX2
34 bile duct cystadenocarcinoma 10.5 KRT7 KRT20
35 anus adenocarcinoma 10.5 KRT7 CDX2
36 jejunal neoplasm 10.5 KRT7 KRT20
37 mucinous adenofibroma 10.5 KRT7 CDX2
38 rectosigmoid junction neoplasm 10.5 KRT7 KRT20
39 sigmoid neoplasm 10.5 KRT7 KRT20
40 urethral diverticulum 10.5 UPK3A KRT7
41 intratubular embryonal carcinoma 10.5 KRT7 KRT20
42 bartholin's gland carcinoma 10.5 KRT7 CDX2
43 malignant syringoma 10.5 KRT7 KRT20
44 mucinous intrahepatic cholangiocarcinoma 10.5 KRT7 CDX2
45 ovarian seromucinous carcinoma 10.5 KRT7 CDX2
46 bartholin's gland disease 10.5 KRT7 CDX2
47 transverse colon cancer 10.5 KRT7 KRT20
48 rectum neuroendocrine neoplasm 10.5 KRT7 CDX2
49 transitional papilloma 10.5 UPK3A KRT7
50 thymus adenocarcinoma 10.5 KRT20 CDX2

Graphical network of the top 20 diseases related to Chronic Cystitis:



Diseases related to Chronic Cystitis

Symptoms & Phenotypes for Chronic Cystitis

MGI Mouse Phenotypes related to Chronic Cystitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 renal/urinary system MP:0005367 9.17 KRT7 PTGS1 PTGS2 TAC1 TRPV1 UPK2

Drugs & Therapeutics for Chronic Cystitis

Drugs for Chronic Cystitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anticonvulsants Phase 1
2 Epidiolex Phase 1
3 Anesthetics

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The CBD-IC Randomized Controlled Trial: Evaluation of Hemp Cannabidiol SuppositoRies for Pain and Urinary SymptOms in INterstitial Cystitis (CHRONIC) Not yet recruiting NCT04349930 Phase 1 Cannabidiol vaginal suppository;Placebo vaginal suppository
2 A Randomized Study of Cystoscopy and Urethral Dilatation Versus Cystoscopy Alone in Women With Overactive Bladder Syndrome and Impaired Voiding. Unknown status NCT00839969

Search NIH Clinical Center for Chronic Cystitis

Genetic Tests for Chronic Cystitis

Anatomical Context for Chronic Cystitis

MalaCards organs/tissues related to Chronic Cystitis:

40
Prostate, Testes, Spinal Cord, Kidney, Lung, Cervix, B Cells

Publications for Chronic Cystitis

Articles related to Chronic Cystitis:

(show top 50) (show all 405)
# Title Authors PMID Year
1
[Expression of cyclooxygenase-2 in human transitional cell bladder carcinomas]. 61 54
12526218 2002
2
Expression of cyclooxygenase-2 in patients with bladder carcinoma. 54 61
11342898 2001
3
Increased nerve growth factor levels in the urinary bladder of women with idiopathic sensory urgency and interstitial cystitis. 61 54
9126085 1997
4
2-naphthylamine toxicity. 61
32118871 2020
5
Questionnaire-guided evaluation of the effectiveness of long-term intravesical 0.2% chondroitin sulfate therapy in interstitial cystitis. 61
32047969 2020
6
Fatty acid amide hydrolase inhibition normalises bladder function and reduces pain through normalising the anandamide/palmitoylethanolamine ratio in the inflamed bladder of rats. 61
31522241 2020
7
Long-term effect of extracorporeal shock wave therapy on attenuating radiation-induced chronic cystitis in rat. 61
32269730 2020
8
Cistus salviifolius Toxicity in Cattle. 61
31662123 2020
9
Activation of NFKB-JMJD3 signaling promotes bladder fibrosis via boosting bladder smooth muscle cell proliferation and collagen accumulation. 61
31102789 2019
10
Biological Characterization and Inhibition of Streptococcus pyogenes ZUH1 Causing Chronic Cystitis by Crocus sativus Methanol Extract, Bee Honey Alone or in Combination with Antibiotics: An In Vitro Study. 61
31405067 2019
11
[Experience of application of hormonal and probiotic therapy in the complex treatment of women in peri- and postmenopausal with chronic recurrent bacterial cystitis in the background of vulvovaginal atrophy]. 61
31356015 2019
12
Successful management of aberrant right hepatic duct during laparoscopic cholecystectomy: a rare case report. 61
31073708 2019
13
Integrated Fourier Transform Infrared Imaging and Proteomics for Identification of a Candidate Histochemical Biomarker in Bladder Cancer. 61
30770125 2019
14
Clinical Outcomes of Volumetric Modulated Arc Therapy Following Intracavitary/Interstitial Brachytherapy in Cervical Cancer: A Single Institution Retrospective Experience. 61
31475110 2019
15
[Some epidemiological aspects of urinary tract infections in Altai regional hospital for veterans of wars]. 61
30742382 2018
16
Eosinophilic cystitis treated with hydrodistention and complementary methods: Case report. 61
30560799 2018
17
Encrusted cystitis caused by corynebacterium urealyticum: a case report with novel treatment strategy of intravesical dimethyl sulfoxide. 61
29697935 2018
18
[The role of modification of innate immunity in development of premature labore]. 61
30378561 2018
19
Chronic Cystitis Associated with Plesiochorus cymbiformis ( Rudolphi, 1819 ) Looss, 1901 (Digenea: Gorgoderidae) in a Loggerhead Turtle Caretta caretta (Linnaeus 1758) (Testudines, Cheloniidae) from Brazil: A Case Report. 61
29394134 2018
20
Increased Piezo1 channel activity in interstitial Cajal-like cells induces bladder hyperactivity by functionally interacting with NCX1 in rats with cyclophosphamide-induced cystitis. 61
29735991 2018
21
Intravesical instillations for the treatment of refractory recurrent urinary tract infections. 61
29623107 2018
22
Androgen Receptor Is Inactivated and Degraded in Bladder Cancer Cells by Phenyl Glucosamine via miR-449a Restoration. 61
29659560 2018
23
Digital quantitative analysis of mast cell infiltration in interstitial cystitis. 61
29065222 2018
24
Extracorporeal shock wave markedly alleviates radiation-induced chronic cystitis in rat. 61
29636892 2018
25
Squamous cell carcinoma of the bladder presented with spontaneous intraperitoneal bladder rupture: A case report. 61
29852423 2018
26
An Immunogenic Peptide, T2 Induces Interstitial Cystitis/Painful Bladder Syndrome: an Autoimmune Mouse Model for Interstitial Cystitis/Painful Bladder Syndrome. 61
28799018 2017
27
Opa interacting protein 5 acts as an oncogene in bladder cancer. 61
28752236 2017
28
Intravesicular administration of sodium hyaluronate ameliorates the inflammation and cell proliferation of cystitis cystica et glandularis involving interleukin-6/JAK2/Stat3 signaling pathway. 61
29162939 2017
29
[The effectiveness of Uroprofit in women with chronic cystitis]. 61
29135143 2017
30
[Experience of using phytolysin in combination therapy of chronic cystitis in patients with urate nephrolythisis]. 61
28952689 2017
31
Expression of MDM2 mRNA, MDM2, P53 and P16 Proteins in Urothelial Lesions in the View of the WHO 4th Edition Guidelines as a Molecular Insight towards Personalized Medicine. 61
28932295 2017
32
Current state of knowledge on the traditional uses, phytochemistry, and pharmacology of the genus Hymenaea. 61
28536059 2017
33
[Troyakov. Experience in using hytolysin in the integrated management of urinary tract infections and methapylactics of nephrolithiasis]. 61
28845934 2017
34
Expression of FGFR3 Protein and Gene Amplification in Urinary Bladder Lesions in Relation to Schistosomiasis. 61
28507621 2017
35
Characterization of ESBL-producing Escherichia coli recovered from companion dogs in Tai'an, China. 61
28368864 2017
36
A rat long-lasting cystitis model induced by intravesical injection of hydrogen peroxide. 61
28242819 2017
37
Alterations of Macrophage Migration Inhibitory Factor Expression in the Nervous System of the Rat Cystitis Model. 61
28161708 2017
38
Pathogenic Features of Dysuria in Young Women with Secondary Amenorrhea Caused by Body Weight Loss. 61
27909963 2016
39
[Diagnosis and treatment of cystitis: more questions than answers?] 61
28248018 2016
40
Inflammation-Induced Adhesin-Receptor Interaction Provides a Fitness Advantage to Uropathogenic E. coli during Chronic Infection. 61
27667696 2016
41
[The role of telomerase activity in non-invasive diagnostics of bladder cancer]. 61
28247730 2016
42
[Complex treatment of chronic cystitis in women]. 61
28247722 2016
43
Androgens Enhance Male Urinary Tract Infection Severity in a New Model. 61
26449605 2016
44
Managing chronic bladder diseases with the administration of exogenous glycosaminoglycans: an update on the evidence. 61
27034722 2016
45
A novel method for assessing bladder-related pain reveals the involvement of nerve growth factor in pain associated with cyclophosphamide-induced chronic cystitis in mice. 61
25820250 2016
46
Urinary kidney injury molecule-1 (KIM-1) excretion in rats with experimental cystitis induced by oxazaphosphorines. 61
29693342 2016
47
Long-lasting pain-related behaviors in mouse chronic cystitis model induced by a single intravesical injection of hydrogen peroxide. 61
26685753 2015
48
Arsenic in Drinking Water, Transition Cell Cancer and Chronic Cystitis in Rural Bangladesh. 61
26516891 2015
49
Intravesical Glycosaminoglycan Replacement with Chondroitin Sulphate (Gepan(®) instill) in Patients with Chronic Radiotherapy- or Chemotherapy-Associated Cystitis. 61
26175064 2015
50
Localization of P2X receptor subtypes 2, 3 and 7 in human urinary bladder. 61
26253104 2015

Variations for Chronic Cystitis

Expression for Chronic Cystitis

Search GEO for disease gene expression data for Chronic Cystitis.

Pathways for Chronic Cystitis

Pathways related to Chronic Cystitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.21 PTGS2 CXCL1 BDNF
2 10.43 PTGS2 PTGS1
3 9.8 PTGS2 PTGS1

GO Terms for Chronic Cystitis

Cellular components related to Chronic Cystitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein-containing complex GO:0032991 9.35 USP7 UPK1A PTGS2 NUMA1 CDX2
2 apical plasma membrane urothelial plaque GO:0120001 8.62 UPK3A UPK1A

Biological processes related to Chronic Cystitis according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.67 PTGS2 NGF BDNF
2 modulation of chemical synaptic transmission GO:0050804 9.65 P2RX3 NGF BDNF
3 memory GO:0007613 9.63 PTGS2 NGF BDNF
4 response to pain GO:0048265 9.58 TRPV1 TAC1
5 epithelial cell differentiation GO:0030855 9.58 UPK3A UPK2 UPK1A
6 neurotrophin TRK receptor signaling pathway GO:0048011 9.57 NGF BDNF
7 prostaglandin biosynthetic process GO:0001516 9.56 PTGS2 PTGS1
8 nerve development GO:0021675 9.55 NGF BDNF
9 behavioral response to pain GO:0048266 9.54 TRPV1 P2RX3
10 nerve growth factor signaling pathway GO:0038180 9.52 NGF BDNF
11 negative regulation of heart rate GO:0010459 9.51 TRPV1 TAC1
12 regulation of blood pressure GO:0008217 9.5 TAC1 PTGS2 PTGS1
13 cyclooxygenase pathway GO:0019371 9.43 PTGS2 PTGS1
14 positive regulation of collateral sprouting GO:0048672 9.37 NGF BDNF
15 inflammatory response GO:0006954 9.35 TRPV1 TAC1 PTGS2 PTGS1 CXCL1
16 sensory perception of pain GO:0019233 9.33 TRPV1 TAC1 PTGS2
17 urinary bladder smooth muscle contraction GO:0014832 9.26 TRPV1 P2RX3
18 cellular response to ATP GO:0071318 8.8 TRPV1 PTGS2 P2RX3

Molecular functions related to Chronic Cystitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nerve growth factor receptor binding GO:0005163 8.96 NGF BDNF
2 prostaglandin-endoperoxide synthase activity GO:0004666 8.62 PTGS2 PTGS1

Sources for Chronic Cystitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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