MCID: CHR087
MIFTS: 35

Chronic Cystitis

Categories: Nephrological diseases

Aliases & Classifications for Chronic Cystitis

MalaCards integrated aliases for Chronic Cystitis:

Name: Chronic Cystitis 12 54 15 17 71

Classifications:



External Ids:

Disease Ontology 12 DOID:1680
ICD9CM 34 595.2
SNOMED-CT 67 197839008
ICD10 32 N30.2
UMLS 71 C0156268 C0221763

Summaries for Chronic Cystitis

MalaCards based summary : Chronic Cystitis is related to radiation cystitis and low compliance bladder. An important gene associated with Chronic Cystitis is NGF (Nerve Growth Factor), and among its related pathways/superpathways are TNF signaling pathway and NF-kappa B signaling pathway. Affiliated tissues include brain, spinal cord and prostate, and related phenotypes are homeostasis/metabolism and integument

Related Diseases for Chronic Cystitis

Diseases in the Cystitis family:

Acute Cystitis Chronic Cystitis

Diseases related to Chronic Cystitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 249)
# Related Disease Score Top Affiliating Genes
1 radiation cystitis 30.2 UPK3A P2RX3
2 low compliance bladder 30.2 P2RX3 NGF
3 glandular cystitis 30.1 UPK3A KRT7 KRT20 CDX2
4 bladder calculus 30.1 UPK1A NUMA1
5 cystitis cystica 30.0 UPK2 KRT7 KRT20 CDX2
6 vesicoureteral reflux 1 29.9 UPK3A UPK2 UPK1A
7 bacteriuria 29.6 TLR4 IL6 CXCL1
8 pyuria 29.6 UPK3A NUMA1 IL6
9 adenomyosis 29.5 PTGS2 NGF IL6
10 transitional cell carcinoma 29.5 UPK3A UPK2 UPK1A PTGS2 KRT7 KRT20
11 acute cystitis 29.3 UPK3A UPK1A TLR4 IL6 CXCL1
12 bladder cancer 29.3 UPK3A UPK2 UPK1A PTGS2 NUMA1 KRT20
13 interstitial cystitis 29.2 UPK3A UPK1A TRPV1 TAC1 P2RX3 NGF
14 cystitis 28.5 UPK3A UPK1A TRPV1 TLR4 TAC1 PTGS2
15 chronic interstitial cystitis 11.0
16 renal pelvis transitional cell carcinoma 10.4 UPK3A KRT7
17 urethral villous adenoma 10.4 KRT7 KRT20
18 vulval paget's disease 10.4 UPK3A KRT7
19 bladder benign neoplasm 10.4 KRT7 KRT20
20 nephrogenic adenoma of urinary bladder 10.4 KRT7 KRT20
21 atrophic vulva 10.4 KRT7 KRT20
22 ovary neuroendocrine neoplasm 10.4 KRT7 CDX2
23 small cell carcinoma of the bladder 10.4 KRT7 KRT20
24 pancreatic serous cystadenocarcinoma 10.4 KRT7 KRT20
25 anal canal paget's disease 10.4 KRT7 CDX2
26 anal paget's disease 10.4 KRT7 CDX2
27 anal gland adenocarcinoma 10.4 KRT7 CDX2
28 urethral diverticulum 10.4 UPK3A KRT7
29 rectosigmoid junction neoplasm 10.4 KRT7 KRT20
30 ureter adenocarcinoma 10.4 KRT7 CDX2
31 anus adenocarcinoma 10.4 KRT7 CDX2
32 transverse colon cancer 10.4 KRT7 KRT20
33 mucinous adenofibroma 10.4 KRT7 CDX2
34 gastric squamous cell carcinoma 10.4 UPK3A KRT7
35 pancreatic foamy gland adenocarcinoma 10.4 KRT7 CDX2
36 urinary bladder small cell neuroendocrine carcinoma 10.4 KRT7 KRT20
37 adenosquamous colon carcinoma 10.4 KRT7 CDX2
38 vulvar apocrine adenocarcinoma 10.4 KRT7 KRT20
39 eyelid carcinoma 10.4 KRT7 KRT20
40 jejunal neoplasm 10.4 KRT7 KRT20
41 colonic lymphangioma 10.4 KRT7 KRT20
42 bartholin's gland disease 10.4 KRT7 CDX2
43 bartholin's gland carcinoma 10.4 KRT7 CDX2
44 thymus adenocarcinoma 10.4 KRT20 CDX2
45 intratubular embryonal carcinoma 10.4 KRT7 KRT20
46 mucinous intrahepatic cholangiocarcinoma 10.4 KRT7 CDX2
47 malignant syringoma 10.4 KRT7 KRT20
48 ovarian seromucinous carcinoma 10.4 KRT7 CDX2
49 rectum neuroendocrine neoplasm 10.4 KRT7 CDX2
50 ovarian large-cell neuroendocrine carcinoma 10.4 KRT7 KRT20

Graphical network of the top 20 diseases related to Chronic Cystitis:



Diseases related to Chronic Cystitis

Symptoms & Phenotypes for Chronic Cystitis

MGI Mouse Phenotypes related to Chronic Cystitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.03 ADCYAP1 CDX2 IL6 KRT7 NGF P2RX3
2 integument MP:0010771 9.76 IL6 NGF P2RX3 PTGS1 PTGS2 TAC1
3 neoplasm MP:0002006 9.43 CDX2 IL6 PTGS1 PTGS2 TLR4 TRPV1
4 renal/urinary system MP:0005367 9.28 IL6 KRT7 PTGS1 PTGS2 TAC1 TLR4

Drugs & Therapeutics for Chronic Cystitis

Search Clinical Trials , NIH Clinical Center for Chronic Cystitis

Genetic Tests for Chronic Cystitis

Anatomical Context for Chronic Cystitis

MalaCards organs/tissues related to Chronic Cystitis:

40
Brain, Spinal Cord, Prostate, Kidney, Cervix, Bone Marrow, Heart

Publications for Chronic Cystitis

Articles related to Chronic Cystitis:

(show top 50) (show all 413)
# Title Authors PMID Year
1
[Expression of cyclooxygenase-2 in human transitional cell bladder carcinomas]. 61 54
12526218 2002
2
Expression of cyclooxygenase-2 in patients with bladder carcinoma. 54 61
11342898 2001
3
Increased nerve growth factor levels in the urinary bladder of women with idiopathic sensory urgency and interstitial cystitis. 54 61
9126085 1997
4
Gabapentin reduces painful bladder hypersensitivity in rats with lipopolysaccharide-induced chronic cystitis. 61
33340266 2021
5
Urotherapist activities in caring for patients with pelvic floor disorders: a prospective single-center observational study. 61
33000294 2021
6
Vesicular Cystitis: A Chronic Cystitis Variant Often Unresponsive to Antibiotics and Electrofulguration. 61
33070139 2021
7
Suppression of adenosine A2a receptors alleviates bladder overactivity and hyperalgesia in cyclophosphamide-induced cystitis by inhibiting TRPV1. 61
33189675 2021
8
[Current trends in the treatment of chronic recurrent bacterial cystitis]. 61
33377679 2020
9
Bladder lesions as incidental findings during transurethral resection of the prostate: prevalence, diagnosis, and pathological findings. 61
32734459 2020
10
[Method of complex therapy of chronic cystitis]. 61
32597584 2020
11
2-naphthylamine toxicity. 61
32118871 2020
12
Questionnaire-guided evaluation of the effectiveness of long-term intravesical 0.2% chondroitin sulfate therapy in interstitial cystitis. 61
32047969 2020
13
Fatty acid amide hydrolase inhibition normalises bladder function and reduces pain through normalising the anandamide/palmitoylethanolamine ratio in the inflamed bladder of rats. 61
31522241 2020
14
Characterization and Validation of a Chronic Model of Cyclophosphamide-Induced Interstitial Cystitis/Bladder Pain Syndrome in Rats. 61
32982733 2020
15
Long-term effect of extracorporeal shock wave therapy on attenuating radiation-induced chronic cystitis in rat. 61
32269730 2020
16
Cistus salviifolius Toxicity in Cattle. 61
31662123 2020
17
Activation of NFKB-JMJD3 signaling promotes bladder fibrosis via boosting bladder smooth muscle cell proliferation and collagen accumulation. 61
31102789 2019
18
Biological Characterization and Inhibition of Streptococcus pyogenes ZUH1 Causing Chronic Cystitis by Crocus sativus Methanol Extract, Bee Honey Alone or in Combination with Antibiotics: An In Vitro Study. 61
31405067 2019
19
[Experience of application of hormonal and probiotic therapy in the complex treatment of women in peri- and postmenopausal with chronic recurrent bacterial cystitis in the background of vulvovaginal atrophy]. 61
31356015 2019
20
Successful management of aberrant right hepatic duct during laparoscopic cholecystectomy: a rare case report. 61
31073708 2019
21
Integrated Fourier Transform Infrared Imaging and Proteomics for Identification of a Candidate Histochemical Biomarker in Bladder Cancer. 61
30770125 2019
22
Clinical Outcomes of Volumetric Modulated Arc Therapy Following Intracavitary/Interstitial Brachytherapy in Cervical Cancer: A Single Institution Retrospective Experience. 61
31475110 2019
23
[Some epidemiological aspects of urinary tract infections in Altai regional hospital for veterans of wars]. 61
30742382 2018
24
Eosinophilic cystitis treated with hydrodistention and complementary methods: Case report. 61
30560799 2018
25
Encrusted cystitis caused by corynebacterium urealyticum: a case report with novel treatment strategy of intravesical dimethyl sulfoxide. 61
29697935 2018
26
[The role of modification of innate immunity in development of premature labore]. 61
30378561 2018
27
Chronic Cystitis Associated with Plesiochorus cymbiformis ( Rudolphi, 1819 ) Looss, 1901 (Digenea: Gorgoderidae) in a Loggerhead Turtle Caretta caretta (Linnaeus 1758) (Testudines, Cheloniidae) from Brazil: A Case Report. 61
29394134 2018
28
Increased Piezo1 channel activity in interstitial Cajal-like cells induces bladder hyperactivity by functionally interacting with NCX1 in rats with cyclophosphamide-induced cystitis. 61
29735991 2018
29
Intravesical instillations for the treatment of refractory recurrent urinary tract infections. 61
29623107 2018
30
Androgen Receptor Is Inactivated and Degraded in Bladder Cancer Cells by Phenyl Glucosamine via miR-449a Restoration. 61
29659560 2018
31
Digital quantitative analysis of mast cell infiltration in interstitial cystitis. 61
29065222 2018
32
Extracorporeal shock wave markedly alleviates radiation-induced chronic cystitis in rat. 61
29636892 2018
33
Squamous cell carcinoma of the bladder presented with spontaneous intraperitoneal bladder rupture: A case report. 61
29852423 2018
34
An Immunogenic Peptide, T2 Induces Interstitial Cystitis/Painful Bladder Syndrome: an Autoimmune Mouse Model for Interstitial Cystitis/Painful Bladder Syndrome. 61
28799018 2017
35
Opa interacting protein 5 acts as an oncogene in bladder cancer. 61
28752236 2017
36
Intravesicular administration of sodium hyaluronate ameliorates the inflammation and cell proliferation of cystitis cystica et glandularis involving interleukin-6/JAK2/Stat3 signaling pathway. 61
29162939 2017
37
[The effectiveness of Uroprofit in women with chronic cystitis]. 61
29135143 2017
38
[Experience of using phytolysin in combination therapy of chronic cystitis in patients with urate nephrolythisis]. 61
28952689 2017
39
Expression of MDM2 mRNA, MDM2, P53 and P16 Proteins in Urothelial Lesions in the View of the WHO 4th Edition Guidelines as a Molecular Insight towards Personalized Medicine. 61
28932295 2017
40
Current state of knowledge on the traditional uses, phytochemistry, and pharmacology of the genus Hymenaea. 61
28536059 2017
41
[Troyakov. Experience in using hytolysin in the integrated management of urinary tract infections and methapylactics of nephrolithiasis]. 61
28845934 2017
42
Expression of FGFR3 Protein and Gene Amplification in Urinary Bladder Lesions in Relation to Schistosomiasis. 61
28507621 2017
43
Characterization of ESBL-producing Escherichia coli recovered from companion dogs in Tai'an, China. 61
28368864 2017
44
A rat long-lasting cystitis model induced by intravesical injection of hydrogen peroxide. 61
28242819 2017
45
Alterations of Macrophage Migration Inhibitory Factor Expression in the Nervous System of the Rat Cystitis Model. 61
28161708 2017
46
Pathogenic Features of Dysuria in Young Women with Secondary Amenorrhea Caused by Body Weight Loss. 61
27909963 2016
47
[Diagnosis and treatment of cystitis: more questions than answers?] 61
28248018 2016
48
Inflammation-Induced Adhesin-Receptor Interaction Provides a Fitness Advantage to Uropathogenic E. coli during Chronic Infection. 61
27667696 2016
49
[The role of telomerase activity in non-invasive diagnostics of bladder cancer]. 61
28247730 2016
50
[Complex treatment of chronic cystitis in women]. 61
28247722 2016

Variations for Chronic Cystitis

Expression for Chronic Cystitis

Search GEO for disease gene expression data for Chronic Cystitis.

Pathways for Chronic Cystitis

GO Terms for Chronic Cystitis

Cellular components related to Chronic Cystitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apical plasma membrane urothelial plaque GO:0120001 8.62 UPK3A UPK1A

Biological processes related to Chronic Cystitis according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of interleukin-6 production GO:0032755 9.69 TLR4 IL6 ADCYAP1
2 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.67 PTGS2 NGF IL6
3 epithelial cell differentiation GO:0030855 9.61 UPK3A UPK2 UPK1A
4 positive regulation of acute inflammatory response GO:0002675 9.55 TAC1 IL6
5 behavioral response to pain GO:0048266 9.54 TRPV1 P2RX3
6 regulation of blood pressure GO:0008217 9.54 TAC1 PTGS2 PTGS1
7 negative regulation of heart rate GO:0010459 9.52 TRPV1 TAC1
8 regulation of neuroinflammatory response GO:0150077 9.48 PTGS2 IL6
9 cyclooxygenase pathway GO:0019371 9.46 PTGS2 PTGS1
10 positive regulation of nitric oxide biosynthetic process GO:0045429 9.43 TRPV1 TLR4 PTGS2
11 positive regulation of lymphocyte proliferation GO:0050671 9.4 TLR4 TAC1
12 cellular response to ATP GO:0071318 9.33 TRPV1 PTGS2 P2RX3
13 urinary bladder smooth muscle contraction GO:0014832 9.32 TRPV1 P2RX3
14 sensory perception of pain GO:0019233 9.26 TRPV1 TAC1 PTGS2 ADCYAP1
15 inflammatory response GO:0006954 9.17 TRPV1 TLR4 TAC1 PTGS2 PTGS1 IL6

Molecular functions related to Chronic Cystitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 prostaglandin-endoperoxide synthase activity GO:0004666 8.62 PTGS2 PTGS1

Sources for Chronic Cystitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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