MCID: CHR465
MIFTS: 21

Chronic Diarrhea Due to Guanylate Cyclase 2c Overactivity

Categories: Gastrointestinal diseases, Genetic diseases, Oral diseases, Rare diseases

Aliases & Classifications for Chronic Diarrhea Due to Guanylate Cyclase 2c Overactivity

MalaCards integrated aliases for Chronic Diarrhea Due to Guanylate Cyclase 2c Overactivity:

Name: Chronic Diarrhea Due to Guanylate Cyclase 2c Overactivity 40 12
Diarrhea 6 40 71
Chronic Diarrhoea Due to Guanylate Cyclase 2c Overactivity 12
Congenital Diarrhoea 6 12
Congenital Diarrhea 6 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0060780
ICD10 32 P78.3
UMLS 71 C3553270

Summaries for Chronic Diarrhea Due to Guanylate Cyclase 2c Overactivity

Disease Ontology : 12 A congenital diarrhea characterized by mild, early-onset chronic diarrhea that has material basis in heterozygous mutation in the GUCY2C gene on chromosome 12p12.

MalaCards based summary : Chronic Diarrhea Due to Guanylate Cyclase 2c Overactivity, also known as diarrhea 6, is related to diarrhea 6 and dysentery. The drugs Acidophilus and Bifidobacterium have been mentioned in the context of this disorder. Affiliated tissues include testes, breast and lung.

Related Diseases for Chronic Diarrhea Due to Guanylate Cyclase 2c Overactivity

Diseases in the Diarrhea family:

Diarrhea 6 Diarrhea 9
Chronic Diarrhea Due to Guanylate Cyclase 2c Overactivity Inflammatory Diarrhea
Acute Diarrhea Congenital Diarrhea

Diseases related to Chronic Diarrhea Due to Guanylate Cyclase 2c Overactivity via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 3, show less)
# Related Disease Score Top Affiliating Genes
1 diarrhea 6 12.7
2 dysentery 9.8
3 diarrhea 9.8

Symptoms & Phenotypes for Chronic Diarrhea Due to Guanylate Cyclase 2c Overactivity

Drugs & Therapeutics for Chronic Diarrhea Due to Guanylate Cyclase 2c Overactivity

Drugs for Chronic Diarrhea Due to Guanylate Cyclase 2c Overactivity (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 2, show less)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Acidophilus
2 Bifidobacterium

Interventional clinical trials:

(showing 4, show less)
# Name Status NCT ID Phase Drugs
1 Clinical Efficacy of Probiotic Bacteria in Subjects With Irritable Bowel Syndrome (IBS), Functional Diarrhea, or Functional Bloating Completed NCT00618904
2 Clinical Utility of Carbohydrate Breath Tests in Unexplained GI Symptoms Completed NCT03261856
3 Fecal Microbiota Transplantation as a Therapeutic Strategy for Patients Infected With HIV Completed NCT04165200
4 Efficacy of GB Mixed Full Strength Rice Suji, and Full Strength Rice Suji Alone Compared to 3/4th Strength Rice Suji in the Management of PD in Children Aged > 6 Months to 36 Months: an Open-labeled Randomized Controlled Clinical Trial Recruiting NCT03366740

Search NIH Clinical Center for Chronic Diarrhea Due to Guanylate Cyclase 2c Overactivity

Genetic Tests for Chronic Diarrhea Due to Guanylate Cyclase 2c Overactivity

Anatomical Context for Chronic Diarrhea Due to Guanylate Cyclase 2c Overactivity

MalaCards organs/tissues related to Chronic Diarrhea Due to Guanylate Cyclase 2c Overactivity:

40
Testes, Breast, Lung, Bone, Small Intestine, Colon, Liver

Publications for Chronic Diarrhea Due to Guanylate Cyclase 2c Overactivity

Articles related to Chronic Diarrhea Due to Guanylate Cyclase 2c Overactivity:

(showing 126, show less)
# Title Authors PMID Year
1
Use of ketogenic diet therapy in infants with epilepsy: A systematic review and meta-analysis. 61
32452537 2020
2
Phase I Study of Alternate-Day Administration of S-1, Oral Leucovorin, and Bevacizumab for Refractory Metastatic Colorectal Cancer. 61
32490554 2020
3
A Phase II Trial of Cabozantinib in Hormone Receptor-Positive Breast Cancer with Bone Metastases. 61
32463152 2020
4
Phase II Study of Ensituximab, a Novel Chimeric Monoclonal Antibody, in Adults with Unresectable, Metastatic Colorectal Cancer. 61
32303539 2020
5
A Phase II Study of Cabozantinib and Androgen Ablation in Patients with Hormone-Naïve Metastatic Prostate Cancer. 61
31941830 2020
6
Oral Vancomycin May Be Associated With Earlier Symptom Resolution Than Metronidazole for Hospitalized Children With Nonsevere Clostridiodes difficile Infections. 61
31950069 2019
7
Lymphocytic esophagitis: An Australian (Queensland) case series of a newly recognized mimic of eosinophilic esophagitis. 61
31633045 2019
8
Association between UGT1A1 gene polymorphism and safety and efficacy of irinotecan monotherapy as the third-line treatment for advanced gastric cancer. 61
30603911 2019
9
Surufatinib in Advanced Well-Differentiated Neuroendocrine Tumors: A Multicenter, Single-Arm, Open-Label, Phase Ib/II Trial. 61
30833272 2019
10
[Efficacy and safety of vandetanib on advanced medullary thyroid carcinoma: single center result from a phase Ⅲ study]. 61
31262109 2019
11
A Phase 1b/2 Study of the Bruton Tyrosine Kinase Inhibitor Ibrutinib and the PD-L1 Inhibitor Durvalumab in Patients with Pretreated Solid Tumors. 61
31230047 2019
12
Multicenter Phase II Study of Sequential Brentuximab Vedotin and Doxorubicin, Vinblastine, and Dacarbazine Chemotherapy for Older Patients With Untreated Classical Hodgkin Lymphoma. 61
30179569 2018
13
Multicenter Phase II Study of Oxaliplatin, Irinotecan, and S-1 as First-line Treatment for Patients with Recurrent or Metastatic Biliary Tract Cancer. 61
29334603 2018
14
A comparative analysis of quality of life after postoperative intensity-modulated radiotherapy or three-dimensional conformal radiotherapy for cervical cancer. 61
30829265 2018
15
Population Pharmacokinetics and Safety of Solithromycin following Intravenous and Oral Administration in Infants, Children, and Adolescents. 61
29891609 2018
16
Enterotoxigenic Escherichia coli Adhesin-Toxoid Multiepitope Fusion Antigen CFA/I/II/IV-3xSTaN12S-mnLTG192G/L211A-Derived Antibodies Inhibit Adherence of Seven Adhesins, Neutralize Enterotoxicity of LT and STa Toxins, and Protect Piglets against Diarrhea. 61
29263112 2018
17
A Case of Mesenteric Cyst in a 4-Year-Old Child with Acute Abdominal Pain. 61
29302510 2017
18
Irinotecan monotherapy as third-line treatment for advanced gastric cancer refractory to fluoropyrimidines, platinum, and taxanes. 61
27858180 2017
19
A final report of a phase I study of veliparib (ABT-888) in combination with low-dose fractionated whole abdominal radiation therapy (LDFWAR) in patients with advanced solid malignancies and peritoneal carcinomatosis with a dose escalation in ovarian and fallopian tube cancers. 61
28109627 2017
20
Optimization of a Scoring System to Predict Microscopic Colitis in a Cohort of Patients With Chronic Diarrhea. 61
27404403 2017
21
Cobimetinib. 61
27701080 2017
22
A phase I study of oral UFT/leucovorin and irinotecan, plus radiation for locally recurrent rectal cancer. 61
31583301 2017
23
Uracil-Tegafur and Oral Leucovorin Combined With Bevacizumab in Elderly Patients (Aged ≥ 75 Years) With Metastatic Colorectal Cancer: A Multicenter, Phase II Trial (Joint Study of Bevacizumab, Oral Leucovorin, and Uracil-Tegafur in Elderly Patients [J-BLUE] Study). 61
26778644 2016
24
The Safety of Metoclopramide in Children: A Systematic Review and Meta-Analysis. 61
27003816 2016
25
Phase II trial of dasatinib for recurrent or metastatic c-KIT expressing adenoid cystic carcinoma and for nonadenoid cystic malignant salivary tumors. 61
26598548 2016
26
A Phase II Randomized Study of Lapatinib Combined With Capecitabine, Vinorelbine, or Gemcitabine in Patients With HER2-Positive Metastatic Breast Cancer With Progression After a Taxane (Latin American Cooperative Oncology Group 0801 Study). 61
26642810 2016
27
Phase 1a/1b and pharmacogenetic study of docetaxel, oxaliplatin and capecitabine in patients with advanced cancer of the stomach or the gastroesophageal junction. 61
26499900 2015
28
Phase II study of capecitabine and the oral mTOR inhibitor everolimus in patients with advanced pancreatic cancer. 61
25822310 2015
29
A phase I study of the histone deacetylase (HDAC) inhibitor entinostat, in combination with sorafenib in patients with advanced solid tumors. 61
25371323 2015
30
[Association of UGT1A1 (*28, *60 and * 93) polymorphism with the adverse reactions of irinotecan chemotherapy in extensive stage small cell lung cancer]. 61
25877315 2015
31
FOLFIRINOX for locally advanced pancreatic adenocarcinoma: results of an AGEO multicenter prospective observational cohort. 61
25037971 2015
32
DPPX potassium channel antibody: frequency, clinical accompaniments, and outcomes in 20 patients. 61
25320100 2014
33
Lapatinib plus capecitabine for HER2-positive advanced breast cancer: a multicentre study of Anatolian Society of Medical Oncology (ASMO). 61
24112786 2014
34
Non-polio enterovirus association with persistent diarrhea in children as revealed by a follow-up study of an Indian cohort during the first two years of life. 61
24954472 2014
35
Breath tests in the diagnosis of small intestinal bacterial overgrowth in patients with irritable bowel syndrome in comparison with quantitative upper gut aspirate culture. 61
24849768 2014
36
Idelalisib, an inhibitor of phosphatidylinositol 3-kinase p110δ, for relapsed/refractory chronic lymphocytic leukemia. 61
24615777 2014
37
Biweekly combination of trastuzumab, docetaxel and gemcitabine for HER2-positive metastatic breast cancer: results of a Phase II GOIM study. 61
24799054 2014
38
[Efficacy and safety of combination of sorafenib and transarterial chemoembolization in treating primary hepatocellular carcinoma]. 61
24581125 2014
39
A phase II study of bevacizumab, oxaliplatin, and capecitabine in patients with previously untreated metastatic colorectal cancer: a prospective, multicenter trial of the Korean Cancer Study Group. 61
23111359 2014
40
[Status of enterovirus infection in children with acute lower respiratory tract infection]. 61
23676941 2013
41
UGT1A1 gene polymorphisms and the toxicities of FOLFIRI in Chinese Han patients with gastrointestinal cancer. 61
22934695 2013
42
Relative effectiveness and safety of chemotherapy in elderly and nonelderly patients with stage III colon cancer: a systematic review. 61
23299774 2013
43
Bevacizumab with erlotinib as first-line therapy in Asian patients with advanced hepatocellular carcinoma: a multicenter phase II study. 61
23838576 2013
44
Final results of an international retrospective observational study in patients with advanced breast cancer treated with oral vinorelbine-based chemotherapy. 61
23060583 2012
45
Bevacizumab plus irinotecan in recurrent malignant glioma shows high overall survival in a multicenter retrospective pooled series of the Spanish Neuro-Oncology Research Group (GEINO). 61
22634799 2012
46
Teething disturbances; prevalence of objective manifestations in children under age 4 months to 36 months. 61
22143712 2012
47
A drug interaction study evaluating the pharmacokinetics and toxicity of sorafenib in combination with capecitabine. 61
21626051 2012
48
What palliative care-related problems do patients experience at HIV diagnosis? A systematic review of the evidence. 61
21620647 2011
49
Systematic review of health-related quality of life after esophagectomy for esophageal cancer. 61
22180708 2011
50
Adjuvant chemoradiation for resected gastric cancer: a 10-year experience. 61
21327926 2011
51
Hospitalized children with 2009 influenza a (H1N1) infection in Shenzhen, China, November-December 2009. 61
20963834 2011
52
Efficacy of a new hypotonic oral rehydration solution containing zinc and prebiotics in the treatment of childhood acute diarrhea: a randomized controlled trial. 61
20828714 2011
53
Phase II study of bolus 5-fluorouracil and leucovorin combined with weekly paclitaxel as first-line therapy for advanced gastric cancer. 61
22134040 2011
54
Efficacy and tolerability of first-line triple therapy with levofloxacin and amoxicillin plus esomeprazole or rabeprazole for the eradication of Helicobacter pylori infection and the effect of CYP2C19 genotype: a 1-week, randomized, open-label study in Chinese adults. 61
21118735 2010
55
Phase I trial of weekly irinotecan and paclitaxel combined with carboplatin in patients with advanced cancer: a Hellenic Cooperative Oncology Group Study. 61
20647930 2010
56
Magnitude and economic effect of overuse of antisecretory therapy in the ambulatory care setting. 61
21250399 2010
57
Prebiotic and probiotic fortified milk in prevention of morbidities among children: community-based, randomized, double-blind, controlled trial. 61
20730056 2010
58
Second-line chemotherapy with irinotecan plus cisplatin after the failure of S-1 monotherapy for advanced gastric cancer. 61
20820988 2010
59
[Characteristics of severely and critically ill children with 2009 influenza A (H1N1) virus infection]. 61
21055298 2010
60
Triweekly oxaliplatin plus oral capecitabine as first-line chemotherapy in elderly patients with advanced gastric cancer. 61
19581793 2009
61
Outbreak of Salmonella Wandsworth and Typhimurium infections in infants and toddlers traced to a commercial vegetable-coated snack food. 61
19779390 2009
62
Pharmacokinetic comparison of a new glimepiride 1-mg + metformin 500-mg combination tablet formulation and a glimepiride 2-mg + metformin 500-mg combination tablet formulation: a single-dose, randomized, open-label, two-period, two-way crossover study in healthy, fasting Korean male volunteers. 61
20110017 2009
63
A phase I study of docetaxel as a radio-sensitizer for locally advanced squamous cell cervical cancer. 61
19251309 2009
64
A phase I study of TS-1 plus carboplatin in patients with advanced non-small-cell lung cancer. 61
19297278 2009
65
Four consecutive multicenter phase II trials of adjuvant chemoradiation in patients with completely resected high-risk gastric cancer: the experience of the German AIO/ARO/CAO group. 61
18825411 2009
66
Pylorus-preserving pancreaticoduodenectomy versus conventional pancreaticoduodenectomy for pancreatic adenocarcinoma. 61
19280281 2009
67
Adverse drug reactions to treatments for ocular toxoplasmosis: a retrospective chart review. 61
19108794 2008
68
Development of functional diarrhea, constipation, irritable bowel syndrome, and dyspepsia during and after traveling outside the USA. 61
17549631 2008
69
Cigarette smoking and irinotecan treatment: pharmacokinetic interaction and effects on neutropenia. 61
17563393 2007
70
Detection of Celiac disease in primary care: a multicenter case-finding study in North America. 61
17355413 2007
71
Gefitinib in combination with tamoxifen in patients with ovarian cancer refractory or resistant to platinum-taxane based therapy--a phase II trial of the AGO Ovarian Cancer Study Group (AGO-OVAR 2.6). 61
17161453 2007
72
Phase II trial of irinotecan in children with relapsed or refractory rhabdomyosarcoma: a joint study of the French Society of Pediatric Oncology and the United Kingdom Children's Cancer Study Group. 61
17264330 2007
73
Phase III trial comparing supportive care alone with supportive care with oral topotecan in patients with relapsed small-cell lung cancer. 61
17135646 2006
74
Sweat test in asthmatic children; a single center study. 61
17237566 2006
75
Salvage chemotherapy with CPT-11 for recurrent meningioma. 61
16628476 2006
76
Systemic vasculitis: a cause of indeterminate intestinal inflammation. 61
16641579 2006
77
A phase II trial of irinotecan in patients with previously untreated advanced esophageal and gastric adenocarcinoma. 61
16416165 2005
78
Case report: the clinical toxicity of dimethylamine borane. 61
16330364 2005
79
Phase II study of the farnesyltransferase inhibitor lonafarnib with paclitaxel in patients with taxane-refractory/resistant nonsmall cell lung carcinoma. 61
16028213 2005
80
Emtricitabine: new preparation. An antiretroviral very similar to lamivudine. 61
15875341 2005
81
Irinotecan combined or alternated with bolus 5-fluorouracil and folinic acid versus the Mayo Clinic regimen in the first-line therapy of advanced colorectal cancer. 61
15756442 2005
82
Randomized multicenter phase II trial of bolus plus infusional fluorouracil/leucovorin compared with fluorouracil/leucovorin plus oxaliplatin as third-line treatment of patients with advanced colorectal cancer. 61
15570076 2004
83
A pharmacodynamic investigation of tacrolimus in pediatric liver transplantation. 61
15048793 2004
84
Dose escalation study on oxaliplatin and capecitabine (Xeloda) in patients with advanced solid tumors. 61
15218291 2004
85
A phase I study of irinotecan as a 3-week schedule in children with refractory or recurrent solid tumors. 61
14551303 2003
86
Does bacterial gastroenteritis predispose people to functional gastrointestinal disorders? A prospective, community-based, case-control study. 61
14499773 2003
87
Continuation of trastuzumab beyond disease progression is feasible and safe in patients with metastatic breast cancer: a retrospective analysis of 80 cases by the hellenic cooperative oncology group. 61
12864940 2003
88
Clinical and demographic features of HIV infection in El Salvador. 61
12831437 2003
89
Clarithromycin extended-release tablet: a review of its use in the management of respiratory tract infections. 61
14720016 2003
90
Whipple's disease. Case report. 61
12532205 2002
91
Radiochemotherapy with short daily infusion of low-dose oxaliplatin, leucovorin, and 5-FU in T3-T4 unresectable rectal cancer: a phase II IATTGI study. 61
12243813 2002
92
Recurrent intracranial ependymoma in children: salvage therapy with oral etoposide. 61
11275460 2001
93
[Cytomegalovirus diarrhea as a diagnostic index for AIDS]. 61
11213580 2000
94
Phase III, randomized, double-blind study of clarithromycin extended-release and immediate-release formulations in the treatment of patients with acute exacerbation of chronic bronchitis. 61
11192133 2000
95
Emergency department presentations of typhoid fever. 61
11074322 2000
96
Eight-hour infusion versus bolus injection of doxorubicin in the EAP regimen in patients with advanced gastric cancer: a prospective randomised trial. 61
10811503 2000
97
Transtubular potassium concentration gradient (TTKG) and urine ammonium in differential diagnosis of hypokalemia. 61
10858974 2000
98
Docetaxel (Taxotere)-cisplatin (TC): an effective drug combination in gastric carcinoma. Swiss Group for Clinical Cancer Research (SAKK), and the European Institute of Oncology (EIO). 61
10811496 2000
99
[Phase II study of docetaxel in inoperable advanced non small cell lung cancer]. 61
10779813 2000
100
Efficacy and safety of ten day moxifloxacin 400 mg once daily in the treatment of patients with community-acquired pneumonia. Community Acquired Pneumonia Study Group. 61
10714413 2000
101
Neutropenic enterocolitis in children with acute lymphoblastic leukemia. 61
10689720 2000
102
[Plesiomonas shigelloides, a Vibrionaceae to be taken into account]. 61
11107887 2000
103
Treatment of Philadelphia chromosome-positive early chronic phase chronic myelogenous leukemia with daily doses of interferon alpha and low-dose cytarabine. 61
10458244 1999
104
Clinical experience with adding delavirdine to combination therapy in patients in whom multiple antiretroviral treatment including protease inhibitors has failed. 61
9708413 1998
105
[Adjuvant radio-chemotherapy in cancer of the rectum treated with radical surgery and with high risk of recurrence. Preliminary results of a prospective study]. 61
9636733 1998
106
Recurrent supratentorial malignant gliomas in children. Long-term salvage therapy with oral etoposide. 61
9152112 1997
107
[Bacterial agglutination test for diagnosis of enterohemorrhagic Escherichia coli(EHEC) infection]. 61
9086780 1997
108
Comparative evaluation of reactogenicity and immunogenicity of two dosages of oral tetravalent rhesus rotavirus vaccine. US Rhesus Rotavirus Vaccine Study Group. 61
8933551 1996
109
Alimentary and respiratory tract lesions in eight medically fragile Holstein cattle with bovine leukocyte adhesion deficiency (BLAD). 61
8740700 1996
110
Clostridium difficile colitis: an efficient clinical approach to diagnosis. 61
7486465 1995
111
Prevalence and pattern of symptoms in patients with cancer pain: a prospective evaluation of 1635 cancer patients referred to a pain clinic. 61
7963790 1994
112
Gastrointestinal leishmaniasis in human immunodeficiency virus-infected patients: report of five cases and review. 61
7948557 1994
113
Acute antiemetic efficacy and safety of dolasetron mesylate, a 5-HT3 antagonist, in cancer patients treated with cisplatin. European Dolasetron Study Group. 61
8141114 1994
114
[Experience with gamma globulins per os in the therapy and prevention of infectious diarrhea]. 61
7505434 1993
115
[Monitoring of postoperative enteral feeding using the H2 breath test]. 61
1903128 1991
116
Clinical and laboratory predictors of bacterial diarrhea in a tropical environment. 61
1900593 1991
117
Clinical features of severe malnutrition at the pediatric ward of Tembakau Deli Hospital, Medan. 61
2077460 1990
118
A phase II trial of cisplatin and 5-fluorouracil with allopurinol for recurrent or metastatic carcinoma of the uterine cervix: a Southwest Oncology Group trial. 61
2351319 1990
119
Microdiverticulitis: a rare but distinct cause of small bowel obstruction in early infancy. 61
3612447 1987
120
Human intestinal infection with Nanophyetus salmincola from salmonid fishes. 61
3578655 1987
121
Phase I study of 2-amino-5-bromo-6-phenyl-4(3H)-pyrimidinone (ABPP), an oral interferon inducer, in cancer patients. 61
2426417 1986
122
Bacterial shock due to transfusion with Yersinia enterocolitica infected blood. 61
6528227 1984
123
Canine protothecosis: review of the literature and report of an additional case. 61
6754671 1982
124
[Laboratory and clinical studies of cefadroxil (author's transl)]. 61
7017197 1981
125
Symposium on diarrhea. 6. Infectious diarrhea. 61
849557 1977
126
ELECTROLYTE BALANCE STUDIES IN ADRENALECTOMIZED DOGS WITH PARTICULAR REFERENCE TO THE EXCRETION OF SODIUM. 61
19870161 1933

Variations for Chronic Diarrhea Due to Guanylate Cyclase 2c Overactivity

Expression for Chronic Diarrhea Due to Guanylate Cyclase 2c Overactivity

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