MCID: CHR563
MIFTS: 51

Chronic Eosinophilic Leukemia

Categories: Blood diseases, Cancer diseases, Rare diseases

Aliases & Classifications for Chronic Eosinophilic Leukemia

MalaCards integrated aliases for Chronic Eosinophilic Leukemia:

Name: Chronic Eosinophilic Leukemia 59 37 73
Pdgfra-Associated Chronic Eosinophilic Leukemia 73

Classifications:



External Ids:

Orphanet 59 ORPHA168940
UMLS via Orphanet 74 C0346421
ICD10 via Orphanet 34 D47.5
KEGG 37 H01590
ICD10 33 D47.5

Summaries for Chronic Eosinophilic Leukemia

MalaCards based summary : Chronic Eosinophilic Leukemia, also known as pdgfra-associated chronic eosinophilic leukemia, is related to pdgfra-associated chronic eosinophilic leukemia and myeloproliferative neoplasm. An important gene associated with Chronic Eosinophilic Leukemia is FIP1L1 (Factor Interacting With PAPOLA And CPSF1), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Cyclophosphamide and Lenograstim have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and t cells, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 76 Chronic eosinophilic leukemia (CEL) is a disease in which too many eosinophils (a type of white blood... more...

Related Diseases for Chronic Eosinophilic Leukemia

Diseases related to Chronic Eosinophilic Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 84)
# Related Disease Score Top Affiliating Genes
1 pdgfra-associated chronic eosinophilic leukemia 34.4 FIP1L1 PDGFRA
2 myeloproliferative neoplasm 31.4 ABL1 FGFR1 FIP1L1 KIT PDGFRA PDGFRB
3 leukemia 30.8 ABL1 FLT3 KIT WT1
4 mastocytosis 30.3 FIP1L1 KIT PDGFRA PDGFRB
5 loeffler endocarditis 30.0 FIP1L1 PDGFRA
6 endomyocardial fibrosis 30.0 FIP1L1 PDGFRA
7 systemic mastocytosis 30.0 FGFR1 FIP1L1 KIT PDGFRA PDGFRB
8 hypereosinophilic syndrome 29.8 ABL1 FGFR1 FIP1L1 IFNA1 KIT PDGFRA
9 hypereosinophilic syndrome, idiopathic 29.8 FIP1L1 KIT PDGFRA PDGFRB WT1
10 myeloid leukemia 29.5 ABL1 FLT3 KIT WT1
11 acute leukemia 29.5 FLT3 KIT WT1
12 myelofibrosis 29.3 FLT3 IFNA1 KIT
13 leukemia, acute myeloid 29.3 ABL1 FLT3 KIT WT1
14 pdgfrb-associated chronic eosinophilic leukemia 12.6
15 reticular perineurioma 10.2 KIT PDGFRA
16 gastric leiomyosarcoma 10.2 KIT PDGFRA
17 conventional fibrosarcoma 10.2 KIT PDGFRA
18 endometrial small cell carcinoma 10.2 KIT PDGFRA
19 lung adenoid cystic carcinoma 10.2 KIT PDGFRA
20 pulmonary vein stenosis 10.2 KIT PDGFRA
21 sm-ahnmd 10.1 FIP1L1 KIT PDGFRA
22 carney triad 10.1 KIT PDGFRA
23 cellular neurofibroma 10.1 ABL1 PDGFRB
24 acute myeloblastic leukemia with maturation 10.1 FLT3 KIT
25 acute myeloid leukemia with t(8;21)(q22;q22) translocation 10.1 FLT3 KIT
26 undifferentiated pleomorphic sarcoma 10.1 KIT PDGFRA
27 corneal dystrophy, subepithelial mucinous 10.1 FIP1L1 PDGFRA PDGFRB
28 lymphoblastic leukemia, acute, with lymphomatous features 10.1 ABL1 FGFR1
29 myeloid and lymphoid neoplasms with eosinophilia and abnormalities of pdgfra, pdgfrb, and fgfr1 10.1 FGFR1 PDGFRA PDGFRB
30 mesenchymal cell neoplasm 10.1 KIT PDGFRA TPM3
31 desmoid tumor 10.1 KIT PDGFRA PDGFRB
32 testicular gonadoblastoma 10.1 KIT WT1
33 gonadoblastoma 10.1 KIT WT1
34 fibrosarcoma of bone 10.1 KIT PDGFRA PDGFRB
35 dermatofibrosarcoma protuberans 10.1 KIT PDGFRA PDGFRB
36 acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 10.1 FLT3 KIT
37 neurofibromatosis, type i 10.1 KIT PDGFRA
38 peritoneal benign neoplasm 10.1 KIT WT1
39 diffuse peritoneal leiomyomatosis 10.1 KIT WT1
40 cystic nephroma 10.0 KIT WT1
41 atypical chronic myeloid leukemia 10.0 ABL1 PDGFRA PDGFRB
42 mixed germ cell-sex cord neoplasm 10.0 KIT WT1
43 spindle cell liposarcoma 10.0 KIT WT1
44 primary hypereosinophilic syndrome 10.0 FGFR1 FIP1L1 PDGFRA PDGFRB
45 cytogenetically normal acute myeloid leukemia 10.0 FLT3 WT1
46 congenital mesoblastic nephroma 10.0 KIT WT1
47 chronic myelomonocytic leukemia 10.0 FLT3 KIT PDGFRB
48 juvenile myelomonocytic leukemia 10.0 FLT3 PDGFRA PDGFRB
49 leukemia, acute lymphoblastic 3 10.0 ABL1 FLT3 PDGFRA
50 prostatic acinar adenocarcinoma 10.0 KIT WT1

Graphical network of the top 20 diseases related to Chronic Eosinophilic Leukemia:



Diseases related to Chronic Eosinophilic Leukemia

Symptoms & Phenotypes for Chronic Eosinophilic Leukemia

GenomeRNAi Phenotypes related to Chronic Eosinophilic Leukemia according to GeneCards Suite gene sharing:

26 (show top 50) (show all 58)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-116 10.7 FLT3
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 10.7 IFNA1
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-14 10.7 IFNA1
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-144 10.7 TPM3
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 10.7 IFNA1 TPM3 FLT3 WT1
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-165 10.7 KIT
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-171 10.7 FLT3
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-173 10.7 TPM3
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-175 10.7 IFNA1
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-18 10.7 KIT
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 10.7 FLT3
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-187 10.7 FLT3
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-200 10.7 TPM3
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-209 10.7 IFNA1 TPM3
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 10.7 TPM3
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-216 10.7 TPM3
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-34 10.7 IFNA1
18 Decreased shRNA abundance (Z-score < -2) GR00366-A-61 10.7 IFNA1 KIT TPM3
19 Decreased shRNA abundance (Z-score < -2) GR00366-A-75 10.7 TPM3
20 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 10.7 TPM3
21 Decreased viability GR00173-A 10.39 FLT3 PDGFRA
22 Decreased viability GR00221-A-1 10.39 ABL1 FGFR1 FLT3 KIT PDGFRA PDGFRB
23 Decreased viability GR00221-A-2 10.39 ABL1 FGFR1
24 Decreased viability GR00221-A-3 10.39 ABL1 PDGFRA PDGFRB
25 Decreased viability GR00221-A-4 10.39 FLT3 PDGFRA PDGFRB
26 Decreased viability GR00301-A 10.39 KIT
27 Decreased viability GR00342-S-1 10.39 ABL1 PDGFRB
28 Decreased viability GR00342-S-2 10.39 ABL1
29 Decreased viability GR00342-S-3 10.39 ABL1
30 Decreased viability GR00402-S-2 10.39 ABL1 FGFR1 FLT3 KIT PDGFRA PDGFRB
31 Increased shRNA abundance (Z-score > 2) GR00366-A-100 10.13 ABL1 WT1
32 Increased shRNA abundance (Z-score > 2) GR00366-A-102 10.13 KIT
33 Increased shRNA abundance (Z-score > 2) GR00366-A-105 10.13 ABL1
34 Increased shRNA abundance (Z-score > 2) GR00366-A-122 10.13 WT1
35 Increased shRNA abundance (Z-score > 2) GR00366-A-123 10.13 ABL1
36 Increased shRNA abundance (Z-score > 2) GR00366-A-151 10.13 ABL1
37 Increased shRNA abundance (Z-score > 2) GR00366-A-152 10.13 KIT WT1
38 Increased shRNA abundance (Z-score > 2) GR00366-A-157 10.13 ABL1 KIT
39 Increased shRNA abundance (Z-score > 2) GR00366-A-170 10.13 KIT
40 Increased shRNA abundance (Z-score > 2) GR00366-A-214 10.13 WT1
41 Increased shRNA abundance (Z-score > 2) GR00366-A-23 10.13 WT1
42 Increased shRNA abundance (Z-score > 2) GR00366-A-3 10.13 ABL1
43 Increased shRNA abundance (Z-score > 2) GR00366-A-30 10.13 ABL1 KIT WT1
44 Increased shRNA abundance (Z-score > 2) GR00366-A-35 10.13 WT1
45 Increased shRNA abundance (Z-score > 2) GR00366-A-42 10.13 KIT
46 Increased shRNA abundance (Z-score > 2) GR00366-A-43 10.13 ABL1 WT1
47 Increased shRNA abundance (Z-score > 2) GR00366-A-47 10.13 ABL1 WT1
48 Increased shRNA abundance (Z-score > 2) GR00366-A-83 10.13 ABL1
49 Increased shRNA abundance (Z-score > 2) GR00366-A-85 10.13 ABL1 KIT WT1
50 Increased shRNA abundance (Z-score > 2) GR00366-A-9 10.13 KIT

MGI Mouse Phenotypes related to Chronic Eosinophilic Leukemia:

46 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.14 ABL1 CDK5RAP2 FGFR1 FLT3 KIT PDGFRA
2 hematopoietic system MP:0005397 10.11 ABL1 CDK5RAP2 FGFR1 FLT3 KIT OSM
3 growth/size/body region MP:0005378 10.08 ABL1 CDK5RAP2 FGFR1 FLT3 KIT PDGFRA
4 endocrine/exocrine gland MP:0005379 10.04 ABL1 FGFR1 FLT3 KIT PDGFRA PDGFRB
5 immune system MP:0005387 10.03 ABL1 CDK5RAP2 FGFR1 FLT3 KIT PDGFRA
6 mortality/aging MP:0010768 10.02 ABL1 CDK5RAP2 FGFR1 FLT3 KIT PDGFRA
7 craniofacial MP:0005382 10 ABL1 CDK5RAP2 FGFR1 KIT PDGFRA PDGFRB
8 embryo MP:0005380 9.99 ABL1 FGFR1 KIT PDGFRA PDGFRB WT1
9 integument MP:0010771 9.88 CDK5RAP2 FGFR1 KIT OSM PDGFRA PDGFRB
10 muscle MP:0005369 9.87 ABL1 FGFR1 KIT PDGFRA PDGFRB TPM3
11 nervous system MP:0003631 9.76 ABL1 CDK5RAP2 FGFR1 KIT OSM PDGFRA
12 neoplasm MP:0002006 9.65 CDK5RAP2 FLT3 KIT PDGFRA WT1
13 no phenotypic analysis MP:0003012 9.43 FGFR1 FLT3 KIT PDGFRA TPM3 WT1
14 skeleton MP:0005390 9.17 ABL1 CDK5RAP2 FGFR1 FLT3 KIT PDGFRA

Drugs & Therapeutics for Chronic Eosinophilic Leukemia

Drugs for Chronic Eosinophilic Leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 261)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyclophosphamide Approved, Investigational Phase 4,Phase 2,Phase 1,Not Applicable 6055-19-2, 50-18-0 2907
2
Lenograstim Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 135968-09-1
3
Thiotepa Approved, Investigational Phase 4,Phase 1 52-24-4 5453
4 Antineoplastic Agents, Alkylating Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
5 Antilymphocyte Serum Phase 4,Phase 2,Phase 1,Not Applicable
6 Alkylating Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
7 Immunologic Factors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
8 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
9 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
10 glucocorticoids Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
11
Ketamine Approved, Vet_approved Phase 3 6740-88-1 3821
12
Cytarabine Approved, Investigational Phase 3,Phase 2,Phase 1 147-94-4 6253
13
Busulfan Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 55-98-1 2478
14
Fludarabine Approved Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable 75607-67-9, 21679-14-1 30751
15
Mycophenolic acid Approved Phase 3,Phase 1,Phase 2,Not Applicable 24280-93-1 446541
16
Aldesleukin Approved Phase 3,Phase 2 85898-30-2, 110942-02-4
17
Daunorubicin Approved Phase 3,Phase 2,Phase 1 20830-81-3 30323
18
Etoposide Approved Phase 3,Phase 2,Phase 1,Not Applicable 33419-42-0 36462
19
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1,Not Applicable 22916-47-8 4189
20
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
21
Thioguanine Approved Phase 3 154-42-7 2723601
22
Acyclovir Approved Phase 3 59277-89-3 2022
23
Amphotericin B Approved, Investigational Phase 3 1397-89-3 5280965 14956
24
Guaifenesin Approved, Investigational, Vet_approved Phase 3,Not Applicable 93-14-1 3516
25
Dextromethorphan Approved Phase 3 125-71-3 5360696 5362449
26
Morphine Approved, Investigational Phase 3,Not Applicable 57-27-2 5288826
27
Mitoxantrone Approved, Investigational Phase 3,Phase 2,Phase 1 65271-80-9 4212
28
Clofarabine Approved, Investigational Phase 2, Phase 3,Phase 1 123318-82-1 119182
29
Melphalan Approved Phase 2, Phase 3,Phase 1,Not Applicable 148-82-3 4053 460612
30
Arsenic trioxide Approved, Investigational Phase 2, Phase 3,Phase 1 1327-53-3 518740
31
alemtuzumab Approved, Investigational Phase 2, Phase 3,Phase 1 216503-57-0
32
Azacitidine Approved, Investigational Phase 2, Phase 3,Phase 1 320-67-2 9444
33
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3,Not Applicable 1177-87-3
34
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Not Applicable 50-02-2 5743
35
Midostaurin Approved, Investigational Phase 3 120685-11-2 104937 9829523
36
Estradiol Approved, Investigational, Vet_approved Phase 3,Not Applicable 50-28-2 5757
37
Moxifloxacin Approved, Investigational Phase 3,Not Applicable 354812-41-2, 151096-09-2 152946
38 Estradiol valerate Approved, Investigational, Vet_approved Phase 3,Not Applicable 979-32-8
39
Polyestradiol phosphate Approved Phase 3,Not Applicable 28014-46-2
40
Norgestimate Approved, Investigational Phase 3,Not Applicable 35189-28-7 6540478
41
Ethinyl Estradiol Approved Phase 3,Not Applicable 57-63-6 5991
42
Ginseng Approved, Investigational, Nutraceutical Phase 3 50647-08-0
43 Pancreatic Polypeptide Investigational Phase 3 59763-91-6
44
tipifarnib Investigational Phase 2, Phase 3,Phase 1 192185-72-1 159324
45 Staurosporine Experimental Phase 3 62996-74-1
46 Anesthetics, Dissociative Phase 3
47 Anesthetics, General Phase 3
48 Excitatory Amino Acid Antagonists Phase 3
49 Excitatory Amino Acids Phase 3
50 Central Nervous System Depressants Phase 3,Phase 2,Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 176)
# Name Status NCT ID Phase Drugs
1 Bone Marrow Transplantation in Treating Patients With Hematologic Cancer Completed NCT00003398 Phase 4 cyclophosphamide;thiotepa
2 Steroid Treatment for Hypereosinophilic Syndrome Recruiting NCT01524536 Phase 4 Corticosteroids
3 Ketamine Hydrochloride and Best Pain Management in Treating Cancer Patients With Neuropathic Pain Unknown status NCT01316744 Phase 3 ketamine hydrochloride
4 Gemtuzumab Ozogamicin in Treating Older Patients With Previously Untreated Acute Myeloid Leukemia Unknown status NCT00091234 Phase 2, Phase 3 gemtuzumab ozogamicin
5 Supersaturated Calcium Phosphate Rinse in Preventing Oral Mucositis in Young Patients Undergoing Autologous or Donor Stem Cell Transplant Completed NCT01305200 Phase 3 supersaturated calcium phosphate rinse
6 Internet-Based Program With or Without Telephone-Based Problem-Solving Training in Helping Long-Term Survivors of Hematopoietic Stem Cell Transplant Cope With Late Complications Completed NCT00799461 Phase 3
7 Combination Chemotherapy With or Without PSC 833, Peripheral Stem Cell Transplantation, and/or Interleukin-2 in Treating Patients With Acute Myeloid Leukemia Completed NCT00006363 Phase 3 cytarabine;daunorubicin hydrochloride;etoposide;valspodar;busulfan
8 Cyclosporine Eye Drops in Preventing Graft-Versus-Host Disease of the Eye in Patients Who Have Undergone Donor Stem Cell Transplant for Hematologic Cancer or Bone Marrow Failure Disorder Completed NCT00755040 Phase 3 cyclosporine ophthalmic emulsion
9 Personalized Information or Basic Information in Helping Patients Make Decisions About Participating in a Clinical Trial Completed NCT00750009 Phase 3
10 American Ginseng in Treating Patients With Fatigue Caused by Cancer Completed NCT00719563 Phase 3 American ginseng
11 Opioid Titration Order Sheet or Standard Care in Treating Patients With Cancer Pain Completed NCT00666211 Phase 3
12 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
13 Music Therapy or Book Discussion in Improving Quality of Life in Young Patients Undergoing Stem Cell Transplant Completed NCT00305851 Phase 3
14 Combination Chemotherapy in Treating Young Patients With Down Syndrome and Acute Myeloid Leukemia or Myelodysplastic Syndromes Completed NCT00369317 Phase 3 asparaginase;daunorubicin hydrochloride;cytarabine;thioguanine;etoposide
15 Valacyclovir in Preventing Cytomegalovirus Infection in Patients Who Are Undergoing Donor Stem Cell Transplantation Completed NCT00045292 Phase 3 acyclovir;acyclovir sodium;valacyclovir
16 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3 liposomal amphotericin B
17 Treatment for Chronic Pain in Patients With Advanced Cancer Completed NCT00003687 Phase 3 dextromethorphan hydrobromide;morphine sulfate
18 Combination Chemotherapy With or Without Gemtuzumab in Treating Young Patients With Newly Diagnosed Acute Myeloid Leukemia Completed NCT00372593 Phase 3 asparaginase;cytarabine;daunorubicin hydrochloride;etoposide;gemtuzumab ozogamicin;mitoxantrone hydrochloride
19 S0106 Cytarabine and Daunorubicin w/ or w/o Gemtuzumab Followed By HD Cytarabine and Either Gemtuzumab or Nothing in de Novo AML Completed NCT00085709 Phase 3 gemtuzumab ozogamicin;Cytosine arabinoside;Daunomycin
20 Combination Chemotherapy With or Without Gemtuzumab Ozogamicin or Tipifarnib in Treating Patients With Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndromes Completed NCT00454480 Phase 2, Phase 3 arsenic trioxide;azacitidine;busulfan;clofarabine;cytarabine;daunorubicin hydrochloride;fludarabine phosphate;gemtuzumab ozogamicin;melphalan;tipifarnib
21 Cytarabine With or Without VNP40101M in Treating Patients With Relapsed Acute Myeloid Leukemia Completed NCT00112554 Phase 3 cytarabine;laromustine
22 Daunorubicin, Cytarabine, and Midostaurin in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia Active, not recruiting NCT00651261 Phase 3 cytarabine;daunorubicin;midostaurin;dexamethasone acetate
23 Moxifloxacin in Preventing Bacterial Infections in Patients Who Have Undergone Donor Stem Cell Transplant Terminated NCT00324324 Phase 3 moxifloxacin hydrochloride;Placebo
24 Mycophenolate Mofetil (MMF) for Treatment of Chronic Graft-versus-host Disease (GVHD) Terminated NCT00089141 Phase 3 mycophenolate mofetil;placebo
25 Study of STI571 in the Treatment of Patients With Idiopathic Hypereosinophilic Syndrome (HES) and Eosinophilic Leukemias Unknown status NCT00276926 Phase 2 STI571
26 Combination Chemotherapy in Treating Patients With Relapsed Acute Myelogenous Leukemia Unknown status NCT00003758 Phase 2 cytarabine;idarubicin
27 Imatinib Mesylate in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia Who Have Received Chemotherapy Unknown status NCT00509093 Phase 2 imatinib mesylate
28 VNP40101M Followed by Cytarabine in Treating Older Patients With Acute Myeloid Leukemia Unknown status NCT00354276 Phase 2 cytarabine;laromustine
29 Efficacy of Imatinib Mesylate in Hypereosinophilic Syndromes Completed NCT00787384 Phase 2 Imatinib
30 A Study of Oral AMN107 in Adults With Chronic Myelogenous Leukemia (CML) or Other Blood Related Cancers Completed NCT00109707 Phase 1, Phase 2 Nilotinib
31 3-AP and Fludarabine in Treating Patients With Myeloproliferative Disorders, Chronic Myelomonocytic Leukemia, or Accelerated Phase or Blastic Phase Chronic Myelogenous Leukemia Completed NCT00381550 Phase 2 fludarabine phosphate;triapine
32 Ondansetron in Preventing Nausea and Vomiting in Patients Undergoing Stem Cell Transplant Completed NCT00795769 Phase 2 ondansetron
33 Beclomethasone Dipropionate in Preventing Acute Graft-Versus-Host Disease in Patients Undergoing a Donor Stem Cell Transplant for Hematologic Cancer Completed NCT00489203 Phase 2 beclomethasone dipropionate;placebo;tacrolimus;methotrexate
34 Donor Natural Killer Cells After Donor Stem Cell Transplant in Treating Patients With Advanced Cancer Completed NCT00823524 Phase 1, Phase 2
35 Fludarabine, Busulfan, and Antilymphocyte Globulin Followed by Donor Stem Cell Transplant in Treating Older Patients With Hematological Cancer Completed NCT00806767 Phase 2 busulfan;fludarabine phosphate
36 Sirolimus, Tacrolimus, and Antithymocyte Globulin in Preventing Graft-Versus-Host Disease in Patients With Hematologic Cancer Who Are Undergoing Donor Stem Cell Transplant Completed NCT00691015 Phase 2 busulfan;carmustine;cyclophosphamide;cytarabine;etoposide;fludarabine phosphate;melphalan;anti-thymocyte globulin IV
37 Alvocidib, Cytarabine, and Mitoxantrone in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia Completed NCT00407966 Phase 2 alvocidib;cytarabine;mitoxantrone hydrochloride
38 Lenalidomide in Treating Older Patients With Acute Myeloid Leukemia Completed NCT00352365 Phase 2 lenalidomide
39 Sirolimus, Tacrolimus, and Methotrexate in Preventing Acute Graft-Versus-Host Disease in Patients With Hematologic Cancer Who Are Undergoing Donor Stem Cell Transplantation Completed NCT00089037 Phase 1, Phase 2 methotrexate;sirolimus;tacrolimus
40 Allogeneic Hematopoietic Cell Transplantation for Patients With Busulfex-based Regimen Completed NCT00448357 Phase 1, Phase 2 busulfan;fludarabine phosphate;tacrolimus;methotrexate
41 Alemtuzumab and Glucocorticoids in Treating Newly Diagnosed Acute Graft-Versus-Host Disease in Patients Who Have Undergone a Donor Stem Cell Transplant Completed NCT00410657 Phase 2 methylprednisolone;prednisone
42 Methotrexate and Glucocorticoids in Treating Patients With Newly Diagnosed Acute Graft-Versus-Host Disease After Donor Stem Cell Transplant Completed NCT00357084 Phase 2 methotrexate;methylprednisolone;prednisone
43 Fludarabine and Busulfan Followed by Donor Peripheral Stem Cell Transplant and Antithymocyte Globulin, Tacrolimus, and Methotrexate in Treating Patients With Myeloid Cancer Completed NCT00346359 Phase 2 busulfan;fludarabine phosphate;methotrexate;tacrolimus
44 Busulfan, Fludarabine, and Total-Body Irradiation in Treating Patients Who Are Undergoing a Donor Stem Cell Transplant for Hematologic Cancer Completed NCT00245037 Phase 1, Phase 2 busulfan;cyclosporine;fludarabine phosphate;mycophenolate mofetil;Granulocyte colony-stimulating factor (G-CSF);Phenytoin;Methotrexate
45 Idarubicin, Cytarabine, and Tipifarnib in Treating Patients With Newly Diagnosed Myelodysplastic Syndromes or Acute Myeloid Leukemia Completed NCT00096122 Phase 1, Phase 2 cytarabine;idarubicin;tipifarnib
46 Combination Chemotherapy, Bone Marrow Transplant, and Post Transplant Cyclophosphamide for Hematologic Cancer Completed NCT00134017 Phase 2 Busulfan;Cyclophosphamide
47 Caspofungin Acetate in Treating Aspergillosis in Patients With Hematologic Cancer or in Patients Who Have Undergone a Stem Cell Transplant Completed NCT00110045 Phase 2 caspofungin acetate
48 Campath-1H + FK506 and Methylprednisolone for GVHD Completed NCT00109993 Phase 2 methylprednisolone;tacrolimus
49 Tacrolimus and Mycophenolate Mofetil in Preventing Acute Graft-Versus-Host Disease in Patients With Advanced Hematologic Cancer Who Are Undergoing Donor Stem Cell Transplantation Completed NCT00096096 Phase 2 mycophenolate mofetil;tacrolimus
50 Combination Chemotherapy and Antithymocyte Globulin in Reducing Graft-Versus-Host Disease in Patients Undergoing Donor Stem Cell Transplantation For Myelodysplastic Syndrome or Myeloproliferative Disorder Completed NCT00054340 Phase 1, Phase 2 busulfan;cyclophosphamide;cyclosporine;methotrexate

Search NIH Clinical Center for Chronic Eosinophilic Leukemia

Genetic Tests for Chronic Eosinophilic Leukemia

Anatomical Context for Chronic Eosinophilic Leukemia

MalaCards organs/tissues related to Chronic Eosinophilic Leukemia:

41
Bone, Bone Marrow, T Cells, Myeloid, Liver, Heart, Lung

Publications for Chronic Eosinophilic Leukemia

Articles related to Chronic Eosinophilic Leukemia:

(show top 50) (show all 106)
# Title Authors Year
1
Discovery of 4-((N-(2-(dimethylamino)ethyl)acrylamido)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide (CHMFL-PDGFR-159) as a highly selective type II PDGFRI+ kinase inhibitor for PDGFRI+ driving chronic eosinophilic leukemia. ( 29544149 )
2018
2
A novel fusion of PDGFRB to TSC1, an intrinsic suppressor of mTOR-signaling pathway, in a chronic eosinophilic leukemia patient with t(5;9)(q32;q34). ( 29384404 )
2018
3
A case of chronic eosinophilic leukemia with secondary transformation to acute myeloid leukemia. ( 29892549 )
2018
4
Integration of a bacterial gene sequence into a chronic eosinophilic leukemia patient's genome as part of a fusion gene linker. ( 28593047 )
2017
5
Bone marrow morphology is a strong discriminator between chronic eosinophilic leukemia, not otherwise specified and reactive idiopathic hypereosinophilic syndrome. ( 28495918 )
2017
6
Loeffler endocarditis in chronic eosinophilic leukemia with FIP1L1/PDGFRA rearrangement: full recovery with low dose imatinib. ( 28651427 )
2017
7
Long-term outcomes of imatinib in patients with FIP1L1/ PDGFRA associated chronic eosinophilic leukemia: experience of a single center in china. ( 27120808 )
2016
8
Complete remission of disseminated granulomatous dermatitis related to chronic eosinophilic leukemia following allogeneic stem cell transplantation. ( 27267816 )
2016
9
Chronic eosinophilic leukemia, NOS with t(5;12)(q31;p13)/ETV6-ACSL6 gene fusion: a novel variant of myeloid proliferative neoplasm with eosinophilia. ( 27458550 )
2016
10
Chronic Eosinophilic Leukemia Presenting Predominantly with Cutaneous Manifestations. ( 27512192 )
2016
11
Targeted next-generation sequencing identifies a subset of idiopathic hypereosinophilic syndrome with features similar to chronic eosinophilic leukemia, not otherwise specified. ( 27174585 )
2016
12
Chronic eosinophilic leukemia with FIP1L1-PDGFRA rearrangement. ( 27722133 )
2016
13
Chronic eosinophilic leukemia with a FIP1L1-PDGFRA rearrangement: Two case reports and a review of Korean cases. ( 25830134 )
2015
14
Delayed diagnosis leading to accelerated phase chronic eosinophilic leukemia due to a cytogenetically cryptic, imatinib-responsive TNIP1-PDFGRB fusion gene. ( 26503642 )
2015
15
Imatinib non-responsive chronic eosinophilic leukemia with ETV6-PDGFRA fusion gene. ( 24975316 )
2015
16
Successful Heart Transplantation for Unreversible Endomyocardial Fibrosis Related to FIP1L1-PDGFRA Chronic Eosinophilic Leukemia. ( 26492057 )
2015
17
Generalized Eruptive Histiocytosis Associated With FIP1L1-PDGFRA-Positive Chronic Eosinophilic Leukemia. ( 25923837 )
2015
18
Murine models of eosinophilic leukemia: a model of FIP1L1-PDGFRI+ initiated chronic eosinophilic leukemia/systemic mastocytosis. ( 24986627 )
2014
19
Chronic eosinophilic leukemia with monosomy 8 in a five-year-old girl: a rare case. ( 25818969 )
2014
20
Chronic eosinophilic leukemia: a rare cause of hypereosinophilic syndrome. ( 25065049 )
2014
21
FIP1L1-PDGFRA-Positive Chronic Eosinophilic Leukemia: A Low-Burden Disease with Dramatic Response to Imatinib - A Report of 5 Cases from South India. ( 24764730 )
2014
22
Identification of kit(M541L) somatic mutation in chronic eosinophilic leukemia, not otherwise specified and its implication in low-dose imatinib response. ( 25015329 )
2014
23
Ponatinib efficiently kills imatinib-resistant chronic eosinophilic leukemia cells harboring gatekeeper mutant T674I FIP1L1-PDGFRI+: roles of Mcl-1 and I^-catenin. ( 24472312 )
2014
24
Successful treatment with imatinib in a patient with chronic eosinophilic leukemia not otherwise specified. ( 24449233 )
2014
25
Chronic eosinophilic leukemia with FIP1L1-PDGFRA. ( 23550302 )
2013
26
Effect of the tyrosine kinase inhibitor nilotinib in patients with hypereosinophilic syndrome/chronic eosinophilic leukemia: analysis of the phase 2, open-label, single-arm A2101 study. ( 24057647 )
2013
27
Efficacy of ruxolitinib in chronic eosinophilic leukemia associated with a PCM1-JAK2 fusion gene. ( 23630205 )
2013
28
Oncostatin M is a FIP1L1/PDGFRA-dependent mediator of cytokine production in chronic eosinophilic leukemia. ( 23621172 )
2013
29
The Spectrum of FIP1L1-PDGFRA-Associated Chronic Eosinophilic Leukemia: New Insights Based on a Survey of 44 Cases. ( 23982058 )
2013
30
Chronic Eosinophilic Leukemia-Not Otherwise Specified (NOS) in the Background of a Large Cell Lymphoma. ( 24224106 )
2013
31
Mast cells and eosinophils in mastocytosis, chronic eosinophilic leukemia, and non-clonal disorders. ( 22449623 )
2012
32
Limited clinical activity of nilotinib and sorafenib in FIP1L1-PDGFRA positive chronic eosinophilic leukemia with imatinib-resistant T674I mutation. ( 21818111 )
2012
33
Chronic eosinophilic leukemia presenting with mouth and penile ulcers. ( 22681908 )
2012
34
Ruxolitinib inhibits transforming JAK2 fusion proteins in vitro and induces complete cytogenetic remission in t(8;9)(p22;p24)/PCM1-JAK2-positive chronic eosinophilic leukemia. ( 22899477 )
2012
35
An imatinib-treated FIL1P1-PDGFRα chronic eosinophilic leukemia transforming to erythroid blast crisis: a case report. ( 21881824 )
2012
36
Chronic eosinophilic leukemia with erythroblastic proliferation and the rare translocation t(8;9)(p22;p24) with PCM1-JAK2 fusion gene: a distinct clinical, pathological and genetic entity with potential treatment target? ( 22288769 )
2012
37
Chronic eosinophilic leukemia-not otherwise specified has a poor prognosis with unresponsiveness to conventional treatment and high risk of acute transformation. ( 22473587 )
2012
38
Successful treatment of ulcerative colitis associated with hypereosinophilic syndrome/chronic eosinophilic leukemia. ( 21841337 )
2011
39
Comparative proteomic analysis of blood eosinophils reveals redox signaling modifications in patients with FIP1L1-PDGFRA-associated chronic eosinophilic leukemia. ( 21302907 )
2011
40
Molecular diagnosis and targeted therapy of a pediatric chronic eosinophilic leukemia patient carrying TPM3-PDGFRB fusion. ( 21072821 )
2011
41
Concomitant FIP1L1-PDGFRA fusion gene and T-cell clonality in a case of chronic eosinophilic leukemia with clonal evolution and an incomplete response to imatinib. ( 21281241 )
2011
42
Complete reversal of left ventricular mass in FIP1L1-PDGFRA-positive chronic eosinophilic leukemia after therapy with imatinib. ( 20609486 )
2011
43
Chronic eosinophilic leukemia with FIP1L1-PDGFRA transcripts after occupational and therapeutic exposure to radiation. ( 22184538 )
2011
44
A chronic eosinophilic leukemia patient presenting with blurred vision. ( 27264376 )
2011
45
Pure red cell aplasia associated with imatinib-treated FIP1L1-PDGFRA positive chronic eosinophilic leukemia. ( 20558942 )
2010
46
Identification and characterization of novel oncogenes in chronic eosinophilic leukemia and T-cell acute lymphoblastic leukemia. ( 20726440 )
2010
47
Alemtuzumab therapy for hypereosinophilic syndrome and chronic eosinophilic leukemia. ( 19118067 )
2009
48
Recent breakthroughs in the understanding and management of chronic eosinophilic leukemia. ( 19761433 )
2009
49
A novel FIP1L1-PDGFRA mutant destabilizing the inactive conformation of the kinase domain in chronic eosinophilic leukemia/hypereosinophilic syndrome. ( 19210352 )
2009
50
Murine model of hypereosinophilic syndromes/chronic eosinophilic leukemia. ( 19494514 )
2009

Variations for Chronic Eosinophilic Leukemia

Expression for Chronic Eosinophilic Leukemia

Search GEO for disease gene expression data for Chronic Eosinophilic Leukemia.

Pathways for Chronic Eosinophilic Leukemia

Pathways related to Chronic Eosinophilic Leukemia according to GeneCards Suite gene sharing:

(show all 29)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.82 ABL1 FGFR1 FLT3 IFNA1 KIT OSM
2
Show member pathways
13.66 ABL1 FGFR1 FLT3 KIT OSM PDGFRA
3
Show member pathways
13.47 FGFR1 FLT3 IFNA1 KIT OSM PDGFRA
4
Show member pathways
13.33 FGFR1 FLT3 IFNA1 KIT PDGFRA PDGFRB
5
Show member pathways
13.22 FGFR1 FLT3 KIT OSM PDGFRA PDGFRB
6
Show member pathways
13.16 FGFR1 FLT3 IFNA1 KIT OSM PDGFRA
7
Show member pathways
13.1 FGFR1 KIT OSM PDGFRA PDGFRB
8
Show member pathways
13.08 FGFR1 FLT3 KIT PDGFRA PDGFRB
9
Show member pathways
12.81 FGFR1 FLT3 KIT PDGFRA PDGFRB
10
Show member pathways
12.75 FGFR1 FLT3 IFNA1 KIT OSM PDGFRA
11 12.61 FGFR1 FLT3 KIT PDGFRA PDGFRB
12
Show member pathways
12.55 FGFR1 KIT PDGFRA PDGFRB
13
Show member pathways
12.55 ABL1 FGFR1 FLT3 KIT PDGFRA PDGFRB
14
Show member pathways
12.52 ABL1 FGFR1 FLT3 KIT PDGFRA PDGFRB
15
Show member pathways
12.26 ABL1 IFNA1 OSM PDGFRA PDGFRB
16
Show member pathways
12.25 FGFR1 FLT3 KIT PDGFRA PDGFRB
17
Show member pathways
12.01 ABL1 FGFR1 IFNA1 KIT PDGFRA PDGFRB
18 11.95 FGFR1 PDGFRA PDGFRB
19 11.95 ABL1 FGFR1 FLT3 IFNA1 KIT PDGFRA
20 11.69 FGFR1 PDGFRA PDGFRB
21
Show member pathways
11.68 FGFR1 FLT3 KIT PDGFRB
22
Show member pathways
11.62 ABL1 KIT PDGFRA PDGFRB
23 11.6 ABL1 FGFR1 FLT3 KIT PDGFRA PDGFRB
24 11.37 FGFR1 PDGFRA PDGFRB
25 11.37 FGFR1 FLT3 KIT PDGFRA PDGFRB
26 11.32 FGFR1 PDGFRA PDGFRB
27 10.97 PDGFRA PDGFRB
28 10.86 FGFR1 FLT3 KIT OSM PDGFRA PDGFRB
29 10.74 PDGFRA PDGFRB

GO Terms for Chronic Eosinophilic Leukemia

Cellular components related to Chronic Eosinophilic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor complex GO:0043235 9.02 FGFR1 FLT3 KIT PDGFRA PDGFRB

Biological processes related to Chronic Eosinophilic Leukemia according to GeneCards Suite gene sharing:

(show all 38)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.99 FGFR1 FLT3 KIT OSM PDGFRA PDGFRB
2 cytokine-mediated signaling pathway GO:0019221 9.94 FLT3 IFNA1 KIT OSM
3 MAPK cascade GO:0000165 9.89 FGFR1 FLT3 KIT PDGFRA PDGFRB
4 cell migration GO:0016477 9.85 FGFR1 PDGFRA PDGFRB
5 regulation of cell proliferation GO:0042127 9.85 ABL1 FGFR1 KIT
6 phosphatidylinositol phosphorylation GO:0046854 9.85 FGFR1 KIT PDGFRA PDGFRB
7 positive regulation of protein kinase B signaling GO:0051897 9.85 FGFR1 KIT OSM PDGFRA PDGFRB
8 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.85 ABL1 FGFR1 FLT3 KIT PDGFRA PDGFRB
9 male gonad development GO:0008584 9.83 KIT PDGFRB WT1
10 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.83 FLT3 KIT PDGFRA PDGFRB
11 negative regulation of signal transduction GO:0009968 9.83 FGFR1 FLT3 KIT PDGFRA PDGFRB
12 cell chemotaxis GO:0060326 9.82 KIT PDGFRA PDGFRB
13 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.8 FLT3 KIT OSM
14 peptidyl-tyrosine phosphorylation GO:0018108 9.8 ABL1 FGFR1 FLT3 KIT PDGFRA PDGFRB
15 positive regulation of MAP kinase activity GO:0043406 9.78 FGFR1 FLT3 KIT PDGFRB
16 phosphatidylinositol-mediated signaling GO:0048015 9.77 FGFR1 PDGFRA PDGFRB
17 platelet-derived growth factor receptor signaling pathway GO:0048008 9.75 ABL1 PDGFRA PDGFRB
18 protein autophosphorylation GO:0046777 9.73 ABL1 FGFR1 FLT3 KIT PDGFRA PDGFRB
19 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.71 FLT3 KIT PDGFRA PDGFRB
20 B cell proliferation GO:0042100 9.68 ABL1 IFNA1
21 adrenal gland development GO:0030325 9.67 PDGFRA WT1
22 cardiac myofibril assembly GO:0055003 9.66 PDGFRA PDGFRB
23 male genitalia development GO:0030539 9.66 PDGFRA WT1
24 regulation of actin cytoskeleton reorganization GO:2000249 9.65 ABL1 PDGFRA
25 metanephric mesenchyme development GO:0072075 9.64 PDGFRB WT1
26 retina vasculature development in camera-type eye GO:0061298 9.63 PDGFRA PDGFRB
27 myeloid progenitor cell differentiation GO:0002318 9.62 FLT3 KIT
28 metanephric S-shaped body morphogenesis GO:0072284 9.62 PDGFRB WT1
29 platelet-derived growth factor receptor-beta signaling pathway GO:0035791 9.61 ABL1 PDGFRB
30 metanephric glomerular capillary formation GO:0072277 9.59 PDGFRA PDGFRB
31 positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway GO:0038091 9.58 PDGFRA PDGFRB
32 positive regulation of phospholipase C activity GO:0010863 9.46 FGFR1 KIT PDGFRA PDGFRB
33 positive regulation of MAPK cascade GO:0043410 9.43 FGFR1 FLT3 KIT OSM PDGFRA PDGFRB
34 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.1 FGFR1 FLT3 KIT OSM PDGFRA PDGFRB
35 cell differentiation GO:0030154 10.09 ABL1 FGFR1 FLT3 KIT PDGFRA PDGFRB
36 phosphorylation GO:0016310 10.04 ABL1 FGFR1 FLT3 KIT PDGFRA PDGFRB
37 protein phosphorylation GO:0006468 10.03 ABL1 FGFR1 FLT3 KIT PDGFRA PDGFRB
38 negative regulation of apoptotic process GO:0043066 10.01 FGFR1 FLT3 KIT PDGFRA PDGFRB WT1

Molecular functions related to Chronic Eosinophilic Leukemia according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 kinase activity GO:0016301 9.88 ABL1 FGFR1 FLT3 KIT PDGFRA PDGFRB
2 protein kinase activity GO:0004672 9.85 ABL1 FGFR1 FLT3 KIT PDGFRA PDGFRB
3 nucleotide binding GO:0000166 9.83 FGFR1 FLT3 KIT PDGFRA PDGFRB
4 transmembrane signaling receptor activity GO:0004888 9.72 FGFR1 FLT3 KIT PDGFRA PDGFRB
5 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.56 FGFR1 KIT PDGFRA PDGFRB
6 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.55 FGFR1 FLT3 KIT PDGFRA PDGFRB
7 platelet-derived growth factor receptor binding GO:0005161 9.51 PDGFRA PDGFRB
8 platelet-derived growth factor binding GO:0048407 9.49 PDGFRA PDGFRB
9 vascular endothelial growth factor-activated receptor activity GO:0005021 9.48 FLT3 PDGFRA
10 vascular endothelial growth factor binding GO:0038085 9.46 PDGFRA PDGFRB
11 protein tyrosine kinase activity GO:0004713 9.43 ABL1 FGFR1 FLT3 KIT PDGFRA PDGFRB
12 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.02 FGFR1 FLT3 KIT PDGFRA PDGFRB
13 transferase activity GO:0016740 10.01 ABL1 FGFR1 FLT3 KIT PDGFRA PDGFRB
14 ATP binding GO:0005524 10 ABL1 FGFR1 FLT3 KIT PDGFRA PDGFRB

Sources for Chronic Eosinophilic Leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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