MCID: CHR037
MIFTS: 49

Chronic Eosinophilic Pneumonia

Categories: Blood diseases, Immune diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Chronic Eosinophilic Pneumonia

MalaCards integrated aliases for Chronic Eosinophilic Pneumonia:

Name: Chronic Eosinophilic Pneumonia 12 54 60 15
Idiopathic Chronic Eosinophilic Pneumonia 54 60
Cryptogenic Pulmonary Eosinophilia 12 74
Carrington Syndrome 54 74
Eosinophilic Idiopathic Chronic Pneumopathy 54
Idiopathic Eosinophilic Chronic Pneumopathy 54
Chronic Idiopathic Eosinophilic Pneumonia 54
Carrington's Pulmonary Eosinophilia 54
Eosinophilic Pneumonia Chronic 56
Carrington's Disease 54

Characteristics:

Orphanet epidemiological data:

60
idiopathic chronic eosinophilic pneumonia
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Iceland); Age of onset: All ages; Age of death: normal life expectancy;

Classifications:



External Ids:

Disease Ontology 12 DOID:9502
NCIt 51 C34471
ICD10 via Orphanet 35 J82
UMLS via Orphanet 75 C0008680 C2930941
Orphanet 60 ORPHA2902

Summaries for Chronic Eosinophilic Pneumonia

NIH Rare Diseases : 54 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.Orpha Number: 2902Disease definitionIdiopathic chronic eosinophilic pneumonia (ICEP) is a very rare, severe, interstitial lung disease of insidious onset with subacute or chronic non-specific respiratory manifestations (dyspnea, cough, wheezing) often associated with systemic manifestations (fatigue, malaise, weight loss).Visit the Orphanet disease page for more resources.

MalaCards based summary : Chronic Eosinophilic Pneumonia, also known as idiopathic chronic eosinophilic pneumonia, is related to eosinophilic pneumonia and pneumonia. An important gene associated with Chronic Eosinophilic Pneumonia is IL5 (Interleukin 5), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Methylprednisolone and Prednisolone phosphate have been mentioned in the context of this disorder. Affiliated tissues include lung, t cells and breast, and related phenotypes are hematopoietic system and immune system

Disease Ontology : 12 An eosinophilic pneumonia which slowly progresses over weeks to months. Life-threatening shortness of breath can develop if the condition is not treated. Individuals are often diagnosed with asthma before the advent of this disease.

Related Diseases for Chronic Eosinophilic Pneumonia

Diseases in the Eosinophilic Pneumonia family:

Chronic Eosinophilic Pneumonia

Diseases related to Chronic Eosinophilic Pneumonia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 166)
# Related Disease Score Top Affiliating Genes
1 eosinophilic pneumonia 31.2 CCL11 CCL5 IL5 RNASE3
2 pneumonia 30.8 CCL11 CCL5 IL5 IL6
3 churg-strauss syndrome 30.6 IL5 RNASE3
4 pulmonary eosinophilia 30.1 CCL11 CCL5 IL5 RNASE3
5 bronchitis 29.9 CCL11 IL5 RNASE3
6 bullous pemphigoid 29.9 CCL11 IL5 RNASE3
7 bronchiolitis obliterans 29.7 CXCR3 IL6
8 allergic hypersensitivity disease 29.5 CCL11 CCL5 IL5 RNASE3
9 bronchiolitis 29.3 CCL11 CCL5 IL5 IL6 RNASE3
10 asthma 29.0 CCL11 CCL5 ICAM1 IL5 IL6 RNASE3
11 lung disease 28.6 CCL5 CXCR3 IL5 IL6 RNASE3
12 pemphigoid gestationis 10.3 CCL11 IL5
13 chronic meningitis 10.3 CCL11 IL5
14 angiostrongyliasis 10.3 CCL11 IL5
15 strongyloidiasis 10.3 CCL11 IL5
16 loeffler endocarditis 10.3 IL5 RNASE3
17 esophagitis, eosinophilic, 1 10.3 CCL11 IL5
18 eosinophilic meningitis 10.3 CCL11 IL5
19 eosinophilic gastritis 10.3 CCL11 IL5
20 cough variant asthma 10.3 IL5 RNASE3
21 cow milk allergy 10.3 IL5 RNASE3
22 milk allergy 10.3 IL5 RNASE3
23 sinusitis 10.3 IL5 RNASE3
24 inflammatory bowel disease 4 10.3 IL5 RNASE3
25 atopic keratoconjunctivitis 10.3 IL5 RNASE3
26 intrinsic asthma 10.3 IL5 RNASE3
27 blepharoconjunctivitis 10.3 CCL11 RNASE3
28 latex allergy 10.3 IL5 RNASE3
29 respiratory syncytial virus infectious disease 10.3 CCL5 IL5
30 giant papillary conjunctivitis 10.3 CCL11 RNASE3
31 urinary schistosomiasis 10.3 IL5 RNASE3
32 night blindness, congenital stationary, type 1a 10.3 CCL11 IL5
33 vulvovaginitis 10.3 CCL11 CCL5
34 wells syndrome 10.2 IL5 RNASE3
35 maxillary sinusitis 10.2 CCL5 RNASE3
36 inclusion conjunctivitis 10.2 CCL5 IL5
37 cellulitis 10.2 IL5 RNASE3
38 bullous skin disease 10.2 CCL5 IL5
39 rheumatoid arthritis 10.2
40 arthritis 10.2
41 allergic angiitis 10.2
42 eosinophilic granulomatosis with polyangiitis 10.2
43 henoch-schoenlein purpura 10.2 ICAM1 RNASE3
44 parasitic helminthiasis infectious disease 10.1 IL5 RNASE3
45 pustulosis palmaris et plantaris 10.1 CXCR3 IL5
46 ige responsiveness, atopic 10.1 IL5 RNASE3
47 mooren's ulcer 10.1 ICAM1 ITGA4
48 lymphoma 10.1
49 actinic prurigo 10.1 ICAM1 ITGA4
50 hydrocele 10.1 ICAM1 ITGA4

Graphical network of the top 20 diseases related to Chronic Eosinophilic Pneumonia:



Diseases related to Chronic Eosinophilic Pneumonia

Symptoms & Phenotypes for Chronic Eosinophilic Pneumonia

MGI Mouse Phenotypes related to Chronic Eosinophilic Pneumonia:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.7 CCL11 CCL5 CXCR3 ICAM1 IL5 IL6
2 immune system MP:0005387 9.5 CCL11 CCL5 CXCR3 ICAM1 IL5 IL6
3 neoplasm MP:0002006 8.92 CXCR3 ICAM1 IL5 IL6

Drugs & Therapeutics for Chronic Eosinophilic Pneumonia

Drugs for Chronic Eosinophilic Pneumonia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
2
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
3
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
4
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
5
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
6 Hormone Antagonists Phase 4
7 Antineoplastic Agents, Hormonal Phase 4
8 Prednisolone acetate Phase 4
9 Neuroprotective Agents Phase 4
10 glucocorticoids Phase 4
11 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
12 Peripheral Nervous System Agents Phase 4
13 Antiemetics Phase 4
14 Anti-Inflammatory Agents Phase 4
15 Gastrointestinal Agents Phase 4
16 Protective Agents Phase 4
17 Methylprednisolone Acetate Phase 4
18 Hormones Phase 4
19 Autonomic Agents Phase 4
20 Immunologic Factors
21 Antibodies
22 Immunoglobulins
23 Antibodies, Monoclonal

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Efficacy of Three Months-prednisolone Therapy for Chronic Eosinophilic Pneumonia Completed NCT00632554 Phase 4 prednisolone 0.5 mg/kg/day for three months;prednisolone 0.5 mg/kg/day for six months
2 Observational Study of Characteristics, Treatment and Outcomes With Severe Asthma in the United States (CHRONICLE) Recruiting NCT03373045

Search NIH Clinical Center for Chronic Eosinophilic Pneumonia

Genetic Tests for Chronic Eosinophilic Pneumonia

Anatomical Context for Chronic Eosinophilic Pneumonia

MalaCards organs/tissues related to Chronic Eosinophilic Pneumonia:

42
Lung, T Cells, Breast, Bone, Skin, Bone Marrow, Monocytes

Publications for Chronic Eosinophilic Pneumonia

Articles related to Chronic Eosinophilic Pneumonia:

(show top 50) (show all 169)
# Title Authors Year
1
Allergic bronchopulmonary aspergillosis in succession to chronic eosinophilic pneumonia. ( 30670338 )
2019
2
Chronic eosinophilic pneumonia after trastuzumab and radiation therapy for breast cancer: A case report. ( 30608451 )
2019
3
Chronic eosinophilic pneumonia: clinical perspectives. ( 30936702 )
2019
4
Pulmonary Actinomycosis in a Patient with Chronic Eosinophilic Pneumonia treated with Omalizumab. ( 28720253 )
2018
5
Long-term management and persistent impairment of pulmonary function in chronic eosinophilic pneumonia: A review of the previous literature. ( 29395966 )
2018
6
Conjunctival Eosinophilic Masses With Chronic Eosinophilic Pneumonia. ( 30044249 )
2018
7
Elevated Levels of Intelectin-1, a Pathogen-binding Lectin, in the BAL Fluid of Patients with Chronic Eosinophilic Pneumonia and Hypersensitivity Pneumonitis. ( 30101907 )
2018
8
A case of chronic eosinophilic pneumonia successfully treated with mepolizumab. ( 30201098 )
2018
9
Anti-interleukin (IL)-5 as a steroid-sparing agent in chronic eosinophilic pneumonia. ( 30444149 )
2018
10
Chronic Eosinophilic Pneumonia with Cardiac Involvement. ( 30627188 )
2018
11
Chronic eosinophilic pneumonia: Adjunctive therapy with inhaled steroids. ( 28626631 )
2017
12
Chronic Eosinophilic Pneumonia: A Diagnostic Challenge. ( 28694046 )
2017
13
Chronic eosinophilic pneumonia after radiation therapy for squamous cell lung cancer. ( 28831373 )
2017
14
Possible Role of IL-25 in Eosinophilic Lung Inflammation in Patients with Chronic Eosinophilic Pneumonia. ( 28875265 )
2017
15
Persistent impairment on spirometry in chronic eosinophilic pneumonia: A longitudinal observation study (Shizuoka-CEP study). ( 28942952 )
2017
16
Response to Omalizumab in a Patient With Chronic Eosinophilic Pneumonia and Poor Response to Corticosteroids. ( 29258701 )
2017
17
The reversed halo sign: also think about chronic eosinophilic pneumonia. ( 29365007 )
2017
18
A must diagnosis of persistent cough: chronic eosinophilic pneumonia (Carrington disease). ( 26782801 )
2016
19
Chronic eosinophilic pneumonia presenting with ipsilateral pleural effusion: a case report. ( 27520469 )
2016
20
The Long-term Clinical Course of Chronic Eosinophilic Pneumonia. ( 27580536 )
2016
21
[A CASE OF EOSINOPHILIC BRONCHIOLITIS COMPLICATED WITH BRONCHIAL ASTHMA AND CHRONIC EOSINOPHILIC PNEUMONIA]. ( 27086960 )
2016
22
Efficacy of short-term prednisolone treatment in patients with chronic eosinophilic pneumonia. ( 25614171 )
2015
23
Complication of chronic eosinophilic pneumonia in an elderly patient with Sjögren syndrome. ( 25899635 )
2015
24
Bronchial involvement in chronic eosinophilic pneumonia: a case report. ( 25973261 )
2015
25
'Photographic negative of pulmonary oedema': a classical radiographic pattern of chronic eosinophilic pneumonia. ( 26155798 )
2015
26
Marked Thrombocytosis in Chronic Eosinophilic Pneumonia and Analysis of Cytokine Mechanism. ( 26490522 )
2015
27
Allergic bronchopulmonary aspergillosis mimicking relapsing chronic eosinophilic pneumonia in non-asthma patient. ( 24368582 )
2014
28
Chronic eosinophilic pneumonia in a breast cancer patient post-radiation therapy: a case report. ( 24026185 )
2014
29
Significance of fractional exhaled nitric oxide in chronic eosinophilic pneumonia: a retrospective cohort study. ( 24885379 )
2014
30
Unusual presentation of chronic eosinophilic pneumonia with "reversed halo sign": a case report. ( 25035707 )
2014
31
A chronic eosinophilic pneumonia case with long exposure to isocyanates. ( 25823164 )
2014
32
Case of invasive mucinous adenocarcinoma mimicking chronic eosinophilic pneumonia. ( 26766997 )
2014
33
Chronic eosinophilic pneumonia: a paediatric case. ( 23625667 )
2013
34
Can omalizumab be effective in chronic eosinophilic pneumonia? ( 23276861 )
2013
35
Diagnosis in just over a minute: a case of chronic eosinophilic pneumonia. ( 23297060 )
2013
36
Chronic eosinophilic pneumonia with persistent decreased diffusing capacity for carbon monoxide. ( 23417937 )
2013
37
Chronic eosinophilic pneumonia: autoimmune phenomenon or immunoallergic disease? Case report and literature review. ( 22196999 )
2012
38
Omalizumab as a steroid-sparing agent in chronic eosinophilic pneumonia. ( 22871762 )
2012
39
Successful treatment of chronic eosinophilic pneumonia with anti-IgE therapy. ( 23091327 )
2012
40
Tracheobronchial involvement in chronic eosinophilic pneumonia. ( 23155215 )
2012
41
Chronic eosinophilic pneumonia due to radiographic contrast administration: an orphan disease? ( 23251088 )
2012
42
Pulmonary cavity due to chronic eosinophilic pneumonia associated with arsenicosis. ( 23279770 )
2012
43
Chronic eosinophilic pneumonia presenting with acute onset. ( 23393913 )
2012
44
Eosinophils and macrophages are involved in nitrosative stress in chronic eosinophilic pneumonia. ( 21440081 )
2011
45
Chronic eosinophilic pneumonia with subpleural curvilinear shadow. ( 21542424 )
2011
46
Chronic eosinophilic pneumonia with endobronchial involvement. ( 23208577 )
2011
47
Churg-Strauss syndrome versus chronic eosinophilic pneumonia on high-resolution computed tomographic findings. ( 20118716 )
2010
48
Chronic eosinophilic pneumonia (Carrington's disease) and rheumatoid arthritis. ( 20627791 )
2010
49
Chronic eosinophilic pneumonia with mucous plugs in a child. ( 20632404 )
2010
50
An association of idiopathic chronic eosinophilic pneumonia with pemphigoid nodularis: a rare variant of bullous pemphigoid. ( 19917977 )
2009

Variations for Chronic Eosinophilic Pneumonia

Expression for Chronic Eosinophilic Pneumonia

Search GEO for disease gene expression data for Chronic Eosinophilic Pneumonia.

Pathways for Chronic Eosinophilic Pneumonia

Pathways related to Chronic Eosinophilic Pneumonia according to GeneCards Suite gene sharing:

(show all 36)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.72 CCL11 CCL5 ICAM1 IL5 IL6 ITGA4
2
Show member pathways
13.58 CCL11 CCL5 CXCR3 IL5 IL6 ITGA4
3
Show member pathways
13.24 CCL11 CCL5 ICAM1 IL5 IL6 ITGA4
4
Show member pathways
13.13 CCL11 CCL5 CXCR3 ICAM1 ITGA4
5
Show member pathways
13.1 CCL11 CCL5 ICAM1 IL5 IL6
6
Show member pathways
13.06 CCL11 CCL5 CXCR3 IL5 IL6 ITGA4
7
Show member pathways
13.04 CCL11 CCL5 CXCR3 IL5 IL6
8
Show member pathways
12.17 CCL11 ICAM1 IL5 IL6 ITGA4 RNASE3
9
Show member pathways
12.14 CCL11 CCL5 ICAM1
10
Show member pathways
12.12 CCL5 ICAM1 IL6
11
Show member pathways
12.11 CCL11 IL5 IL6
12
Show member pathways
11.87 CCL11 CCL5 CXCR3 ICAM1 ITGA4
13
Show member pathways
11.81 CCL11 CCL5 CXCR3
14 11.79 CCL11 ICAM1 IL6
15 11.77 CCL5 ICAM1 IL6
16 11.7 IL5 IL6 ITGA4
17 11.65 CCL5 ICAM1 IL6
18 11.58 ICAM1 IL5 IL6
19
Show member pathways
11.57 CCL11 CCL5 ICAM1 IL5 IL6
20 11.56 CXCR3 IL5 ITGA4
21 11.48 CCL11 CCL5 IL6
22 11.36 ICAM1 IL6
23 11.35 ICAM1 IL6
24 11.34 IL5 IL6
25 11.33 CCL11 IL6
26 11.32 CCL11 IL5
27 11.29 ICAM1 ITGA4
28 11.27 CCL5 ICAM1 IL6
29 11.21 ICAM1 IL6
30 11.19 CCL5 IL6
31 11.16 CCL11 CXCR3
32 11.13 IL5 IL6
33 11.09 IL5 IL6
34 10.79 CCL11 CCL5 IL5 IL6
35 10.72 CCL11 CCL5 IL5 IL6
36 10.62 CCL11 CCL5 IL5 IL6 ITGA4

GO Terms for Chronic Eosinophilic Pneumonia

Cellular components related to Chronic Eosinophilic Pneumonia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.1 CCL11 CCL5 ICAM1 IL5 IL6 RNASE3

Biological processes related to Chronic Eosinophilic Pneumonia according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.87 CCL11 CXCR3 ICAM1 ITGA4
2 regulation of signaling receptor activity GO:0010469 9.81 CCL11 CCL5 IL5 IL6
3 positive regulation of GTPase activity GO:0043547 9.77 CCL11 CCL5 ICAM1
4 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.75 CCL11 CCL5 ICAM1
5 chemotaxis GO:0006935 9.72 CCL11 CCL5 CXCR3
6 immune response GO:0006955 9.72 CCL11 CCL5 CXCR3 IL5 IL6
7 cellular response to tumor necrosis factor GO:0071356 9.7 CCL11 CCL5 ICAM1
8 cellular response to interferon-gamma GO:0071346 9.65 CCL11 CCL5 ICAM1
9 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.63 ICAM1 IL5 IL6
10 positive regulation of smooth muscle cell proliferation GO:0048661 9.61 CCL5 IL6
11 cellular response to interleukin-1 GO:0071347 9.61 CCL11 CCL5 ICAM1
12 positive regulation of actin filament polymerization GO:0030838 9.59 CCL11 ICAM1
13 lymphocyte chemotaxis GO:0048247 9.58 CCL11 CCL5
14 chemokine-mediated signaling pathway GO:0070098 9.58 CCL11 CCL5 CXCR3
15 eosinophil chemotaxis GO:0048245 9.56 CCL11 CCL5
16 positive regulation of T cell migration GO:2000406 9.54 CCL5 ITGA4
17 monocyte chemotaxis GO:0002548 9.54 CCL11 CCL5 IL6
18 positive regulation of immunoglobulin secretion GO:0051024 9.49 IL5 IL6
19 leukocyte cell-cell adhesion GO:0007159 9.43 CCL5 ICAM1 ITGA4
20 inflammatory response GO:0006954 9.35 CCL11 CCL5 CXCR3 IL5 IL6
21 positive regulation of JAK-STAT cascade GO:0046427 9.33 CCL5 IL5 IL6
22 cytokine-mediated signaling pathway GO:0019221 9.02 CCL11 CCL5 ICAM1 IL5 IL6

Molecular functions related to Chronic Eosinophilic Pneumonia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine activity GO:0008009 9.16 CCL11 CCL5
2 CCR chemokine receptor binding GO:0048020 8.96 CCL11 CCL5
3 cytokine activity GO:0005125 8.92 CCL11 CCL5 IL5 IL6

Sources for Chronic Eosinophilic Pneumonia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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