MCID: CHR037
MIFTS: 48

Chronic Eosinophilic Pneumonia

Categories: Rare diseases, Respiratory diseases, Immune diseases

Aliases & Classifications for Chronic Eosinophilic Pneumonia

MalaCards integrated aliases for Chronic Eosinophilic Pneumonia:

Name: Chronic Eosinophilic Pneumonia 12 53 59 15
Cryptogenic Pulmonary Eosinophilia 12 73
Carrington Syndrome 53 73
Eosinophilic Idiopathic Chronic Pneumopathy 53
Idiopathic Eosinophilic Chronic Pneumopathy 53
Chronic Idiopathic Eosinophilic Pneumonia 53
Idiopathic Chronic Eosinophilic Pneumonia 59
Carrington's Pulmonary Eosinophilia 53
Eosinophilic Pneumonia Chronic 55
Carrington's Disease 53

Characteristics:

Orphanet epidemiological data:

59
idiopathic chronic eosinophilic pneumonia
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Iceland); Age of onset: All ages; Age of death: normal life expectancy;

Classifications:



External Ids:

Disease Ontology 12 DOID:9502
NCIt 50 C34471
SNOMED-CT 68 233692000
Orphanet 59 ORPHA2902
ICD10 via Orphanet 34 J82
UMLS via Orphanet 74 C0008680 C2930941

Summaries for Chronic Eosinophilic Pneumonia

Disease Ontology : 12 An eosinophilic pneumonia which slowly progresses over weeks to months. Life-threatening shortness of breath can develop if the condition is not treated. Individuals are often diagnosed with asthma before the advent of this disease.

MalaCards based summary : Chronic Eosinophilic Pneumonia, also known as cryptogenic pulmonary eosinophilia, is related to churg-strauss syndrome and eosinophilic pneumonia. An important gene associated with Chronic Eosinophilic Pneumonia is IL5 (Interleukin 5), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Prednisolone and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include t cells, lung and breast, and related phenotypes are hematopoietic system and immune system

Related Diseases for Chronic Eosinophilic Pneumonia

Diseases in the Eosinophilic Pneumonia family:

Chronic Eosinophilic Pneumonia

Diseases related to Chronic Eosinophilic Pneumonia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 163)
# Related Disease Score Top Affiliating Genes
1 churg-strauss syndrome 30.7 IL5 RNASE3
2 eosinophilic pneumonia 30.4 CCL11 CCL5 IL5 RNASE3
3 pneumonia 30.3 CCL11 CCL5 IL5 IL6
4 bronchiolitis obliterans 29.8 CXCR3 IL6
5 bronchitis 29.6 CCL11 IL5 RNASE3
6 bullous pemphigoid 29.6 CCL11 IL5 RNASE3
7 pulmonary eosinophilia 29.4 CCL11 CCL5 IL5 RNASE3
8 bronchiolitis 28.4 CCL11 CCL5 IL5 IL6 RNASE3
9 asthma 27.0 CCL11 CCL5 ICAM1 IL5 IL6 RNASE3
10 pemphigoid gestationis 10.6 CCL11 IL5
11 chronic meningitis 10.6 CCL11 IL5
12 angiostrongyliasis 10.6 CCL11 IL5
13 strongyloidiasis 10.6 CCL11 IL5
14 eosinophilic meningitis 10.6 CCL11 IL5
15 eosinophilic gastritis 10.6 CCL11 IL5
16 loeffler endocarditis 10.5 IL5 RNASE3
17 cough variant asthma 10.5 IL5 RNASE3
18 inflammatory bowel disease 4 10.5 IL5 RNASE3
19 cow milk allergy 10.5 IL5 RNASE3
20 esophagitis, eosinophilic, 1 10.5 CCL11 IL5
21 intrinsic asthma 10.5 IL5 RNASE3
22 atopic keratoconjunctivitis 10.5 IL5 RNASE3
23 latex allergy 10.5 IL5 RNASE3
24 urinary schistosomiasis 10.5 IL5 RNASE3
25 night blindness, congenital stationary, type 1a 10.5 CCL11 IL5
26 blepharoconjunctivitis 10.5 CCL11 RNASE3
27 cellulitis 10.5 IL5 RNASE3
28 giant papillary conjunctivitis 10.5 CCL11 RNASE3
29 sinusitis 10.5 IL5 RNASE3
30 angioimmunoblastic lymphadenopathy with dysproteinemia 10.5 IL5 IL6
31 bagassosis 10.5 IL5 IL6
32 respiratory syncytial virus infectious disease 10.5 CCL5 IL5
33 ascaris lumbricoides infection 10.4 IL5 IL6
34 milk allergy 10.4 IL5 RNASE3
35 wells syndrome 10.4 IL5 RNASE3
36 multicentric castleman disease 10.4 IL5 IL6
37 primary amebic meningoencephalitis 10.4 IL5 IL6
38 vulvovaginitis 10.4 CCL11 CCL5
39 mesenteric lymphadenitis 10.4 IL5 IL6
40 papillary conjunctivitis 10.4 CCL11 IL6
41 maxillary sinusitis 10.4 CCL5 RNASE3
42 myelitis 10.3 CCL11 IL6
43 yellow fever 10.3 CCL5 IL5
44 scorpion envenomation 10.3 CCL5 IL6
45 parasitic helminthiasis infectious disease 10.3 IL5 RNASE3
46 obesity-hypoventilation syndrome 10.3 CCL5 IL6
47 paracoccidioidomycosis 10.3 IL5 IL6
48 pustulosis palmaris et plantaris 10.3 CXCR3 IL5
49 echinococcosis 10.3 IL5 IL6
50 stachybotrys chartarum 10.2 CCL5 IL6

Graphical network of the top 20 diseases related to Chronic Eosinophilic Pneumonia:



Diseases related to Chronic Eosinophilic Pneumonia

Symptoms & Phenotypes for Chronic Eosinophilic Pneumonia

MGI Mouse Phenotypes related to Chronic Eosinophilic Pneumonia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.63 IL6 CCL11 CCL5 CXCR3 ICAM1 IL5
2 immune system MP:0005387 9.43 IL5 IL6 CCL11 CCL5 CXCR3 ICAM1
3 neoplasm MP:0002006 8.92 IL5 IL6 CXCR3 ICAM1

Drugs & Therapeutics for Chronic Eosinophilic Pneumonia

Drugs for Chronic Eosinophilic Pneumonia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
2
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
3 Prednisolone acetate Phase 4
4 glucocorticoids Phase 4
5 Methylprednisolone acetate Phase 4
6 Methylprednisolone Hemisuccinate Phase 4
7 Gastrointestinal Agents Phase 4
8 Neuroprotective Agents Phase 4
9 Hormone Antagonists Phase 4
10 Hormones Phase 4
11 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
12 Peripheral Nervous System Agents Phase 4
13 Prednisolone hemisuccinate Phase 4
14 Prednisolone phosphate Phase 4
15 Antiemetics Phase 4
16 Protective Agents Phase 4
17 Anti-Inflammatory Agents Phase 4
18 Autonomic Agents Phase 4
19 Antineoplastic Agents, Hormonal Phase 4
20 Antibodies
21 Immunoglobulins
22 Antibodies, Monoclonal

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Efficacy of Three Months-prednisolone Therapy for Chronic Eosinophilic Pneumonia Completed NCT00632554 Phase 4 prednisolone 0.5 mg/kg/day for three months;prednisolone 0.5 mg/kg/day for six months
2 Observational Study of Characteristics, Treatment and Outcomes With Severe Asthma in the United States (CHRONICLE) Recruiting NCT03373045

Search NIH Clinical Center for Chronic Eosinophilic Pneumonia

Genetic Tests for Chronic Eosinophilic Pneumonia

Anatomical Context for Chronic Eosinophilic Pneumonia

MalaCards organs/tissues related to Chronic Eosinophilic Pneumonia:

41
T Cells, Lung, Breast, Bone, Monocytes, Bone Marrow

Publications for Chronic Eosinophilic Pneumonia

Articles related to Chronic Eosinophilic Pneumonia:

(show top 50) (show all 158)
# Title Authors Year
1
Long-term management and persistent impairment of pulmonary function in chronic eosinophilic pneumonia: A review of the previous literature. ( 29395966 )
2018
2
Pulmonary Actinomycosis in a Patient with Chronic Eosinophilic Pneumonia treated with Omalizumab. ( 28720253 )
2017
3
Response to Omalizumab in a Patient With Chronic Eosinophilic Pneumonia and Poor Response to Corticosteroids. ( 29258701 )
2017
4
Chronic eosinophilic pneumonia after radiation therapy for squamous cell lung cancer. ( 28831373 )
2017
5
Possible Role of IL-25 in Eosinophilic Lung Inflammation in Patients with Chronic Eosinophilic Pneumonia. ( 28875265 )
2017
6
Chronic eosinophilic pneumonia: Adjunctive therapy with inhaled steroids. ( 28626631 )
2017
7
Chronic Eosinophilic Pneumonia: A Diagnostic Challenge. ( 28694046 )
2017
8
The reversed halo sign: also think about chronic eosinophilic pneumonia. ( 29365007 )
2017
9
Persistent impairment on spirometry in chronic eosinophilic pneumonia: a longitudinal observation study (Shizuoka-CEP study). ( 28942952 )
2017
10
Chronic eosinophilic pneumonia presenting with ipsilateral pleural effusion: a case report. ( 27520469 )
2016
11
A CASE OF EOSINOPHILIC BRONCHIOLITIS COMPLICATED WITH BRONCHIAL ASTHMA AND CHRONIC EOSINOPHILIC PNEUMONIA. ( 27086960 )
2016
12
The Long-term Clinical Course of Chronic Eosinophilic Pneumonia. ( 27580536 )
2016
13
Bronchial involvement in chronic eosinophilic pneumonia: a case report. ( 25973261 )
2015
14
'Photographic negative of pulmonary oedema': a classical radiographic pattern of chronic eosinophilic pneumonia. ( 26155798 )
2015
15
Efficacy of short-term prednisolone treatment in patients with chronic eosinophilic pneumonia. ( 25614171 )
2015
16
Marked Thrombocytosis in Chronic Eosinophilic Pneumonia and Analysis of Cytokine Mechanism. ( 26490522 )
2015
17
A must diagnosis of persistent cough: chronic eosinophilic pneumonia (Carrington disease). ( 26782801 )
2015
18
Complication of chronic eosinophilic pneumonia in an elderly patient with sjAPgren syndrome. ( 25899635 )
2015
19
A chronic eosinophilic pneumonia case with long exposure to isocyanates. ( 25823164 )
2014
20
Unusual presentation of chronic eosinophilic pneumonia with "reversed halo sign": a case report. ( 25035707 )
2014
21
Case of invasive mucinous adenocarcinoma mimicking chronic eosinophilic pneumonia. ( 26766997 )
2014
22
Significance of fractional exhaled nitric oxide in chronic eosinophilic pneumonia: a retrospective cohort study. ( 24885379 )
2014
23
Chronic eosinophilic pneumonia: a paediatric case. ( 23625667 )
2013
24
Can omalizumab be effective in chronic eosinophilic pneumonia? ( 23276861 )
2013
25
Allergic Bronchopulmonary Aspergillosis Mimicking Relapsing Chronic Eosinophilic Pneumonia in Non-Asthma Patient. ( 24368582 )
2013
26
Chronic eosinophilic pneumonia with persistent decreased diffusing capacity for carbon monoxide. ( 23417937 )
2013
27
Diagnosis in just over a minute: a case of chronic eosinophilic pneumonia. ( 23297060 )
2013
28
Chronic Eosinophilic Pneumonia in a Breast Cancer Patient Post Radiation Therapy: A Case Report. ( 24026185 )
2013
29
Tracheobronchial involvement in chronic eosinophilic pneumonia. ( 23155215 )
2012
30
Omalizumab as a steroid-sparing agent in chronic eosinophilic pneumonia. ( 22871762 )
2012
31
Chronic eosinophilic pneumonia presenting with acute onset. ( 23393913 )
2012
32
Chronic eosinophilic pneumonia: autoimmune phenomenon or immunoallergic disease? Case report and literature review. ( 22196999 )
2012
33
Pulmonary cavity due to chronic eosinophilic pneumonia associated with arsenicosis. ( 23279770 )
2012
34
Chronic eosinophilic pneumonia due to radiographic contrast administration: an orphan disease? ( 23251088 )
2012
35
Successful treatment of chronic eosinophilic pneumonia with anti-IgE therapy. ( 23091327 )
2012
36
Chronic eosinophilic pneumonia with subpleural curvilinear shadow. ( 21542424 )
2011
37
Eosinophils and macrophages are involved in nitrosative stress in chronic eosinophilic pneumonia. ( 21440081 )
2011
38
Chronic eosinophilic pneumonia with endobronchial involvement. ( 23208577 )
2011
39
Churg-Strauss syndrome versus chronic eosinophilic pneumonia on high-resolution computed tomographic findings. ( 20118716 )
2010
40
Chronic eosinophilic pneumonia with mucous plugs in a child. ( 20632404 )
2010
41
Chronic eosinophilic pneumonia (Carrington's disease) and rheumatoid arthritis. ( 20627791 )
2010
42
Chronic eosinophilic pneumonia associated with neurofibromatosis type 1: an unusual complication. ( 19262016 )
2009
43
Chronic eosinophilic pneumonia: a case report and review of the literature. ( 19830005 )
2009
44
An association of idiopathic chronic eosinophilic pneumonia with pemphigoid nodularis: a rare variant of bullous pemphigoid. ( 19917977 )
2009
45
Diffuse idiopathic pulmonary neuroendocrine hyperplasia, chronic eosinophilic pneumonia, and asthma. ( 19948916 )
2009
46
Chronic eosinophilic pneumonia secondary to long-term use of nitrofurantoin: high-resolution computed tomography findings. ( 18392467 )
2008
47
Differences in regulatory T cells between Churg-Strauss syndrome and chronic eosinophilic pneumonia with asthma. ( 18586318 )
2008
48
Chronic eosinophilic pneumonia in a 13-year-old child. ( 18202853 )
2008
49
Idiopathic chronic eosinophilic pneumonia in 7 horses. ( 18466259 )
2008
50
Soluble CD26 is inversely Associated with Disease Severity in Patients with Chronic Eosinophilic Pneumonia. ( 19690650 )
2007

Variations for Chronic Eosinophilic Pneumonia

Expression for Chronic Eosinophilic Pneumonia

Search GEO for disease gene expression data for Chronic Eosinophilic Pneumonia.

Pathways for Chronic Eosinophilic Pneumonia

Pathways related to Chronic Eosinophilic Pneumonia according to GeneCards Suite gene sharing:

(show all 29)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.7 CCL11 CCL5 ICAM1 IL5 IL6 RNASE3
2
Show member pathways
13.37 CCL11 CCL5 CXCR3 IL5 IL6
3
Show member pathways
13.05 CCL11 CCL5 CXCR3 IL5 IL6
4
Show member pathways
13 CCL11 CCL5 ICAM1 IL5 IL6
5
Show member pathways
12.94 CCL11 CCL5 CXCR3 IL5 IL6
6
Show member pathways
12.29 CCL11 ICAM1 IL5 IL6 RNASE3
7
Show member pathways
12.07 CCL11 CCL5 ICAM1
8
Show member pathways
12.04 CCL5 ICAM1 IL6
9
Show member pathways
12.03 CCL11 IL5 IL6
10
Show member pathways
11.7 CCL11 CCL5 CXCR3
11 11.67 CCL11 ICAM1 IL6
12 11.61 CCL5 ICAM1 IL6
13 11.5 CCL5 ICAM1 IL6
14 11.44 CCL11 IL5
15
Show member pathways
11.44 ICAM1 IL6
16 11.41 ICAM1 IL5 IL6
17
Show member pathways
11.37 CCL11 CCL5 ICAM1 IL5 IL6
18 11.31 ICAM1 IL6
19 11.3 ICAM1 IL6
20 11.29 IL5 IL6
21 11.28 CCL11 IL6
22 11.26 CCL11 IL5
23 11.14 ICAM1 IL6
24 11.13 CCL5 IL6
25 11.12 CCL5 ICAM1 IL6
26 11.11 CCL11 CXCR3
27 11.07 IL5 IL6
28 11.03 IL5 IL6
29 10.72 CCL11 CCL5 IL5 IL6

GO Terms for Chronic Eosinophilic Pneumonia

Cellular components related to Chronic Eosinophilic Pneumonia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.35 CCL11 CCL5 IL5 IL6 RNASE3
2 extracellular space GO:0005615 9.1 CCL11 CCL5 ICAM1 IL5 IL6 RNASE3

Biological processes related to Chronic Eosinophilic Pneumonia according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.81 CCL11 CCL5 IL5 IL6
2 regulation of signaling receptor activity GO:0010469 9.76 CCL11 CCL5 IL5 IL6
3 positive regulation of GTPase activity GO:0043547 9.75 CCL11 CCL5 ICAM1
4 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.73 CCL11 CCL5 ICAM1
5 chemotaxis GO:0006935 9.7 CCL11 CCL5 CXCR3
6 cellular response to tumor necrosis factor GO:0071356 9.67 CCL11 CCL5 ICAM1
7 neutrophil chemotaxis GO:0030593 9.61 CCL11 CCL5
8 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.61 CCL5 IL6
9 cellular response to interferon-gamma GO:0071346 9.61 CCL11 CCL5 ICAM1
10 positive regulation of T cell proliferation GO:0042102 9.6 CCL5 IL6
11 positive regulation of smooth muscle cell proliferation GO:0048661 9.59 CCL5 IL6
12 positive regulation of actin filament polymerization GO:0030838 9.58 CCL11 ICAM1
13 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.58 ICAM1 IL5 IL6
14 lymphocyte chemotaxis GO:0048247 9.57 CCL11 CCL5
15 leukocyte cell-cell adhesion GO:0007159 9.55 CCL5 ICAM1
16 eosinophil chemotaxis GO:0048245 9.54 CCL11 CCL5
17 cellular response to interleukin-1 GO:0071347 9.54 CCL11 CCL5 ICAM1
18 chemokine-mediated signaling pathway GO:0070098 9.5 CCL11 CCL5 CXCR3
19 positive regulation of immunoglobulin secretion GO:0051024 9.48 IL5 IL6
20 monocyte chemotaxis GO:0002548 9.43 CCL11 CCL5 IL6
21 inflammatory response GO:0006954 9.35 CCL11 CCL5 CXCR3 IL5 IL6
22 positive regulation of JAK-STAT cascade GO:0046427 9.33 CCL5 IL5 IL6
23 cytokine-mediated signaling pathway GO:0019221 9.02 CCL11 CCL5 ICAM1 IL5 IL6

Molecular functions related to Chronic Eosinophilic Pneumonia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine activity GO:0008009 9.16 CCL11 CCL5
2 CCR chemokine receptor binding GO:0048020 8.96 CCL11 CCL5
3 cytokine activity GO:0005125 8.92 CCL11 CCL5 IL5 IL6

Sources for Chronic Eosinophilic Pneumonia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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