MCID: CHR037
MIFTS: 46

Chronic Eosinophilic Pneumonia

Categories: Blood diseases, Immune diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Chronic Eosinophilic Pneumonia

MalaCards integrated aliases for Chronic Eosinophilic Pneumonia:

Name: Chronic Eosinophilic Pneumonia 12 53 59 15
Idiopathic Chronic Eosinophilic Pneumonia 53 59
Cryptogenic Pulmonary Eosinophilia 12 72
Carrington Syndrome 53 72
Eosinophilic Idiopathic Chronic Pneumopathy 53
Idiopathic Eosinophilic Chronic Pneumopathy 53
Chronic Idiopathic Eosinophilic Pneumonia 53
Carrington's Pulmonary Eosinophilia 53
Eosinophilic Pneumonia Chronic 55
Carrington's Disease 53

Characteristics:

Orphanet epidemiological data:

59
idiopathic chronic eosinophilic pneumonia
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Iceland); Age of onset: All ages; Age of death: normal life expectancy;

Classifications:



External Ids:

Disease Ontology 12 DOID:9502
NCIt 50 C34471
ICD10 via Orphanet 34 J82
UMLS via Orphanet 73 C0008680 C2930941
Orphanet 59 ORPHA2902
UMLS 72 C0008680 C2930941

Summaries for Chronic Eosinophilic Pneumonia

NIH Rare Diseases : 53 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.Orpha Number: 2902DefinitionIdiopathic chronic eosinophilic pneumonia (ICEP) is a very rare, severe, interstitial lung disease of insidious onset with subacute or chronic non-specific respiratory manifestations (dyspnea, cough, wheezing) often associated with systemic manifestations (fatigue, malaise, weight loss).Visit the Orphanet disease page for more resources.

MalaCards based summary : Chronic Eosinophilic Pneumonia, also known as idiopathic chronic eosinophilic pneumonia, is related to hypereosinophilic syndrome and eosinophilic pneumonia. An important gene associated with Chronic Eosinophilic Pneumonia is IL5 (Interleukin 5), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Prednisolone phosphate and Methylprednisolone hemisuccinate have been mentioned in the context of this disorder. Affiliated tissues include lung, t cells and bone, and related phenotypes are hematopoietic system and immune system

Disease Ontology : 12 An eosinophilic pneumonia which slowly progresses over weeks to months. Life-threatening shortness of breath can develop if the condition is not treated. Individuals are often diagnosed with asthma before the advent of this disease.

Related Diseases for Chronic Eosinophilic Pneumonia

Diseases in the Eosinophilic Pneumonia family:

Chronic Eosinophilic Pneumonia

Diseases related to Chronic Eosinophilic Pneumonia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 231)
# Related Disease Score Top Affiliating Genes
1 hypereosinophilic syndrome 31.4 RNASE3 IL5 CCL11
2 eosinophilic pneumonia 31.2 RNASE3 IL5 CCL5 CCL11
3 churg-strauss syndrome 31.2 RNASE3 IL5
4 intrinsic asthma 30.8 RNASE3 IL5
5 ige responsiveness, atopic 30.5 RNASE3 IL5
6 esophagitis, eosinophilic, 1 30.5 IL5 CCL11
7 wells syndrome 30.4 RNASE3 IL5
8 bronchitis 30.3 RNASE3 IL5 CCL11
9 pneumonia 30.2 IL6 IL5 CCL5 CCL2 CCL11
10 pulmonary eosinophilia 30.1 RNASE3 IL5 CCL5 CCL11
11 bullous pemphigoid 30.0 RNASE3 IL5 CCL11
12 bronchiolitis obliterans 30.0 IL6 CXCR3
13 anterior uveitis 29.9 IL6 CCL2
14 esophagitis 29.9 IL6 IL5 CCL11
15 nonspecific interstitial pneumonia 29.8 CXCR3 CCL2
16 interstitial lung disease 29.8 IL6 CCL5 CCL2
17 allergic rhinitis 29.7 RNASE3 IL5 ICAM1 CCL11
18 bronchiolitis 29.6 RNASE3 IL6 IL5 CCL5 CCL11
19 allergic asthma 29.4 RNASE3 IL5 CCL5 CCL11
20 allergic hypersensitivity disease 29.4 RNASE3 IL5 CCL5 CCL11
21 rheumatoid arthritis 29.2 IL6 ICAM1 CCL5 CCL2
22 pulmonary fibrosis, idiopathic 29.2 CXCR3 CCL5 CCL2
23 rhinitis 29.1 RNASE3 IL5 ICAM1 CCL5 CCL11
24 uveitis 28.8 ICAM1 CXCR3 CCL2
25 human immunodeficiency virus type 1 28.8 IL6 CCL5 CCL2 CCL11
26 common cold 28.7 RNASE3 IL5 ICAM1 CCL5 CCL11
27 dermatitis, atopic 28.7 RNASE3 IL5 ICAM1 CCL5 CCL11
28 extrinsic allergic alveolitis 28.5 IL6 CXCR3 CCL5 CCL2
29 lung disease 28.2 RNASE3 IL6 IL5 CXCR3 CCL5 CCL2
30 asthma 27.5 RNASE3 IL6 IL5 ICAM1 CCL5 CCL2
31 proteasome-associated autoinflammatory syndrome 1 27.1 RNASE3 IL6 IL5 ICAM1 CCL5 CCL2
32 pemphigoid gestationis 10.5 IL5 CCL11
33 chronic meningitis 10.5 IL5 CCL11
34 angiostrongyliasis 10.5 IL5 CCL11
35 loeffler endocarditis 10.5 RNASE3 IL5
36 strongyloidiasis 10.5 IL5 CCL11
37 eosinophilic meningitis 10.5 IL5 CCL11
38 eosinophilic gastritis 10.5 IL5 CCL11
39 cough variant asthma 10.5 RNASE3 IL5
40 cow milk allergy 10.5 RNASE3 IL5
41 milk allergy 10.5 RNASE3 IL5
42 atopic keratoconjunctivitis 10.5 RNASE3 IL5
43 inflammatory bowel disease 4 10.5 RNASE3 IL5
44 blepharoconjunctivitis 10.5 RNASE3 CCL11
45 latex allergy 10.5 RNASE3 IL5
46 urinary schistosomiasis 10.5 RNASE3 IL5
47 giant papillary conjunctivitis 10.5 RNASE3 CCL11
48 respiratory syncytial virus infectious disease 10.5 IL5 CCL5
49 night blindness, congenital stationary, type 1a 10.4 IL5 CCL11
50 vulvovaginitis 10.4 CCL5 CCL11

Graphical network of the top 20 diseases related to Chronic Eosinophilic Pneumonia:



Diseases related to Chronic Eosinophilic Pneumonia

Symptoms & Phenotypes for Chronic Eosinophilic Pneumonia

MGI Mouse Phenotypes related to Chronic Eosinophilic Pneumonia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.43 CCL11 CCL5 CXCR3 ICAM1 IL5 IL6
2 immune system MP:0005387 9.17 CCL11 CCL2 CCL5 CXCR3 ICAM1 IL5

Drugs & Therapeutics for Chronic Eosinophilic Pneumonia

Drugs for Chronic Eosinophilic Pneumonia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
2
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
3
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
4
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
5
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
6 glucocorticoids Phase 4
7 Gastrointestinal Agents Phase 4
8 Neuroprotective Agents Phase 4
9 Hormones Phase 4
10 Methylprednisolone Acetate Phase 4
11 Antiemetics Phase 4
12 Anti-Inflammatory Agents Phase 4
13 Peripheral Nervous System Agents Phase 4
14 Antineoplastic Agents, Hormonal Phase 4
15 Protective Agents Phase 4
16 Hormone Antagonists Phase 4
17 Prednisolone acetate Phase 4
18 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
19 Autonomic Agents Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase 4, Randomized Study of Three Months-prednisolone Therapy in the Treatment of Chronic Eosinophilic Pneumonia Completed NCT00632554 Phase 4 prednisolone 0.5 mg/kg/day for three months;prednisolone 0.5 mg/kg/day for six months

Search NIH Clinical Center for Chronic Eosinophilic Pneumonia

Genetic Tests for Chronic Eosinophilic Pneumonia

Anatomical Context for Chronic Eosinophilic Pneumonia

MalaCards organs/tissues related to Chronic Eosinophilic Pneumonia:

41
Lung, T Cells, Bone, Bone Marrow, Breast, Colon, Skin

Publications for Chronic Eosinophilic Pneumonia

Articles related to Chronic Eosinophilic Pneumonia:

(show top 50) (show all 407)
# Title Authors PMID Year
1
Elevated interleukin-18 levels in bronchoalveolar lavage fluid of patients with eosinophilic pneumonia. 9 38
15230818 2004
2
Eotaxin and monocyte chemoattractant protein-1 in chronic eosinophilic pneumonia. 9 38
11488333 2001
3
Evaluation of CD30 as a marker for th2 lymphocytes in bronchoalveolar lavage in interstitial lung diseases. 9 38
10845432 2000
4
Predominant implication of IL-5 in acute eosinophilic pneumonia: comparison with chronic eosinophilic pneumonia. 9 38
9623513 1998
5
[Chronic eosinophilic pneumonia associated with high concentrations of interleukin-5, -6, and granulocyte colony stimulating factor in serum and in pleural fluid]. 9 38
9366161 1997
6
Eosinophil cationic protein and immunoglobulin levels in bronchoalveolar lavage fluid obtained from patients with chronic eosinophilic pneumonia. 9 38
8980958 1996
7
[Chronic eosinophilic pneumonia involving eosinophil cationic protein and bone marrow cells]. 9 38
8953906 1996
8
[A case of chronic eosinophilic pneumonia involving IL-5 and GM-CSF]. 9 38
7609343 1995
9
Eosinophilic cationic protein in chronic eosinophilic pneumonia and eosinophilic granuloma. 9 38
7956407 1994
10
Segregation of eosinophil proteins in alveolar macrophage compartments in chronic eosinophilic pneumonia. 9 38
8434356 1993
11
Allergic bronchopulmonary aspergillosis in succession to chronic eosinophilic pneumonia. 38
30670338 2019
12
Eosinophilic pneumonia: A review of the previous literature, causes, diagnosis, and management. 38
31253537 2019
13
10-Year Follow-Up of Frequently Relapsed Chronic Eosinophilic Pneumonia Starting at 15 Years Old; Attempts to Treat with Inhaled Corticosteroid (A Case Report). 38
31182706 2019
14
Authenticity of pulmonary Lophomonas blattarum infection: A case report. 38
30637258 2019
15
A case of chronic eosinophilic pneumonia in a patient treated with dupilumab. 38
31371974 2019
16
Chronic eosinophilic pneumonia after trastuzumab and radiation therapy for breast cancer: A case report. 38
30608451 2019
17
Elevated Periostin Concentrations in the Bronchoalveolar Lavage Fluid of Patients with Eosinophilic Pneumonia. 38
30612125 2019
18
Targeting eosinophils: severe asthma and beyond. 38
31391853 2019
19
Chronic eosinophilic pneumonia: clinical perspectives. 38
30936702 2019
20
[Chronic eosinophilic pneumonia in octogenarian patient]. 38
30396788 2019
21
Elevated Levels of Intelectin-1, a Pathogen-binding Lectin, in the BAL Fluid of Patients with Chronic Eosinophilic Pneumonia and Hypersensitivity Pneumonitis. 38
30101907 2018
22
[Vasculitides and eosinophilic pulmonary diseases]. 38
30367242 2018
23
Indeterminate dendritic cell neoplasm accompanied by eosinophilic pneumonia successfully treated by systemic steroid therapy: Report of the first case with muscular and parotid involvement and review of published work. 38
30320463 2018
24
Eosinophilic lung disease with plastic bronchitis and bronchiectasis in an adolescent male. 38
30564338 2018
25
Anti-interleukin (IL)-5 as a steroid-sparing agent in chronic eosinophilic pneumonia. 38
30444149 2018
26
Favorable response to asthma-dosed subcutaneous mepolizumab in eosinophilic pneumonia. 38
30395734 2018
27
Innate immune response reflects disease activity in eosinophilic granulomatosis with polyangiitis. 38
29908086 2018
28
Conjunctival Eosinophilic Masses With Chronic Eosinophilic Pneumonia. 38
30044249 2018
29
A case of chronic eosinophilic pneumonia successfully treated with mepolizumab. 38
30201098 2018
30
[Vasculitides and eosinophilic pulmonary diseases]. 38
30140942 2018
31
Long-term management and persistent impairment of pulmonary function in chronic eosinophilic pneumonia: A review of the previous literature. 38
29395966 2018
32
Asthmatic adult with marked blood eosinophilia: is it truly asthma? 38
29735492 2018
33
[Clinical Analysis of 40 Patients with Eosinophilic Lung Diseases in Peking Union Medical College Hospital]. 38
29724306 2018
34
Chronic Eosinophilic Pneumonia with Cardiac Involvement. 38
30627188 2018
35
Chronic cough and an atypical pattern of peripheral pulmonary opacities: A case report secondary to suspected drug onset. 38
28402696 2018
36
Pulmonary Actinomycosis in a Patient with Chronic Eosinophilic Pneumonia treated with Omalizumab. 38
28720253 2018
37
Response to Omalizumab in a Patient With Chronic Eosinophilic Pneumonia and Poor Response to Corticosteroids. 38
29258701 2017
38
Possible Role of IL-25 in Eosinophilic Lung Inflammation in Patients with Chronic Eosinophilic Pneumonia. 38
28875265 2017
39
Chronic Eosinophilic Pneumonia: A Diagnostic Challenge. 38
28694046 2017
40
High-resolution computed tomography findings in chronic eosinophilic vs. cryptogenic organising pneumonia. 38
29037300 2017
41
Persistent impairment on spirometry in chronic eosinophilic pneumonia: A longitudinal observation study (Shizuoka-CEP study). 38
28942952 2017
42
Elevated uric acid and adenosine triphosphate concentrations in bronchoalveolar lavage fluid of eosinophilic pneumonia. 38
28705588 2017
43
The reversed halo sign: also think about chronic eosinophilic pneumonia. 38
29365007 2017
44
Eosinophilic pneumonia caused by daptomycin: Six cases from two institutions and a review of the literature. 38
28003110 2017
45
Chronic eosinophilic pneumonia after radiation therapy for squamous cell lung cancer. 38
28831373 2017
46
Chronic eosinophilic pneumonia: Adjunctive therapy with inhaled steroids. 38
28626631 2017
47
High-resolution computed tomography to differentiate chronic diffuse infiltrative lung diseases with chronic multifocal consolidation patterns using logical analysis of data. 38
28079848 2016
48
Plugs of the Air Passages: A Clinicopathologic Review. 38
27445091 2016
49
Radiologic finding of bronchial asthma. 38
30551273 2016
50
Chronic eosinophilic pneumonia presenting with ipsilateral pleural effusion: a case report. 38
27520469 2016

Variations for Chronic Eosinophilic Pneumonia

Expression for Chronic Eosinophilic Pneumonia

Search GEO for disease gene expression data for Chronic Eosinophilic Pneumonia.

Pathways for Chronic Eosinophilic Pneumonia

Pathways related to Chronic Eosinophilic Pneumonia according to GeneCards Suite gene sharing:

(show all 42)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.76 RNASE3 IL6 IL5 ICAM1 CCL5 CCL2
2
Show member pathways
13.62 IL6 IL5 CXCR3 CCL5 CCL2 CCL11
3
Show member pathways
13.43 IL6 IL5 CXCR3 CCL5 CCL2 CCL11
4
Show member pathways
13.31 IL6 IL5 ICAM1 CCL5 CCL2 CCL11
5
Show member pathways
13.2 IL6 IL5 CXCR3 CCL5 CCL2 CCL11
6
Show member pathways
13.17 ICAM1 CXCR3 CCL5 CCL2 CCL11
7
Show member pathways
13.14 IL6 IL5 ICAM1 CCL5 CCL2 CCL11
8
Show member pathways
13.02 IL6 IL5 CXCR3 CCL5 CCL2 CCL11
9
Show member pathways
12.76 IL6 ICAM1 CCL5 CCL2
10
Show member pathways
12.71 RNASE3 IL6 IL5 ICAM1 CCL11
11
Show member pathways
12.69 CXCR3 CCL5 CCL2 CCL11
12
Show member pathways
12.17 ICAM1 CCL5 CCL11
13
Show member pathways
12.17 IL6 ICAM1 CCL5 CCL2
14
Show member pathways
12.16 IL6 IL5 CCL2 CCL11
15
Show member pathways
12.09 CXCR3 CCL5 CCL2 CCL11
16
Show member pathways
12.01 ICAM1 CXCR3 CCL5 CCL2 CCL11
17 11.86 IL6 ICAM1 CCL2
18 11.79 IL6 ICAM1 CCL2 CCL11
19 11.77 IL6 ICAM1 CCL2
20 11.75 IL6 ICAM1 CCL5 CCL2
21 11.67 IL6 IL5 ICAM1
22 11.64 IL6 ICAM1 CCL5 CCL2
23 11.47 IL6 CCL5 CCL2 CCL11
24
Show member pathways
11.45 IL6 IL5 ICAM1 CCL5 CCL2 CCL11
25 11.41 IL6 ICAM1 CCL2
26 11.37 IL6 IL5
27 11.37 IL6 ICAM1
28 11.35 IL6 CCL11
29 11.34 IL5 CCL11
30 11.24 IL6 ICAM1
31 11.22 IL6 CCL5
32 11.19 IL6 CCL2
33 11.19 CXCR3 CCL11
34 11.16 IL6 IL5
35 11.15 IL6 ICAM1 CCL5 CCL2
36 11.11 IL6 IL5
37 11.04 ICAM1 CCL2
38 10.91 CCL2 CCL11
39 10.89 IL6 IL5 CCL5 CCL2 CCL11
40 10.82 ICAM1 CCL2
41 10.82 IL6 IL5 CCL5 CCL2 CCL11
42 10.8 IL6 IL5 CCL5 CCL2 CCL11

GO Terms for Chronic Eosinophilic Pneumonia

Cellular components related to Chronic Eosinophilic Pneumonia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 RNASE3 IL6 IL5 CCL5 CCL2 CCL11
2 extracellular space GO:0005615 9.17 RNASE3 IL6 IL5 ICAM1 CCL5 CCL2

Biological processes related to Chronic Eosinophilic Pneumonia according to GeneCards Suite gene sharing:

(show all 28)
# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.91 ICAM1 CXCR3 CCL2 CCL11
2 positive regulation of GTPase activity GO:0043547 9.85 ICAM1 CCL5 CCL2 CCL11
3 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.83 ICAM1 CCL5 CCL2 CCL11
4 chemotaxis GO:0006935 9.8 CXCR3 CCL5 CCL2 CCL11
5 MAPK cascade GO:0000165 9.79 IL5 CCL5 CCL2
6 cellular response to lipopolysaccharide GO:0071222 9.77 IL6 ICAM1 CCL2
7 regulation of cell shape GO:0008360 9.77 ICAM1 CCL2 CCL11
8 cellular response to tumor necrosis factor GO:0071356 9.76 ICAM1 CCL5 CCL2 CCL11
9 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.74 IL6 IL5 ICAM1
10 cell chemotaxis GO:0060326 9.73 CXCR3 CCL5 CCL2
11 immune response GO:0006955 9.73 IL6 IL5 CXCR3 CCL5 CCL2 CCL11
12 neutrophil chemotaxis GO:0030593 9.71 CCL5 CCL2 CCL11
13 cellular response to interferon-gamma GO:0071346 9.71 ICAM1 CCL5 CCL2 CCL11
14 lymphocyte chemotaxis GO:0048247 9.69 CCL5 CCL2 CCL11
15 cellular response to interleukin-1 GO:0071347 9.67 ICAM1 CCL5 CCL2 CCL11
16 positive regulation of JAK-STAT cascade GO:0046427 9.65 IL6 IL5 CCL5
17 positive regulation of actin filament polymerization GO:0030838 9.64 ICAM1 CCL11
18 protein kinase B signaling GO:0043491 9.63 CCL5 CCL2
19 lipopolysaccharide-mediated signaling pathway GO:0031663 9.63 CCL5 CCL2
20 cellular response to fibroblast growth factor stimulus GO:0044344 9.62 CCL5 CCL2
21 chemokine-mediated signaling pathway GO:0070098 9.62 CXCR3 CCL5 CCL2 CCL11
22 leukocyte cell-cell adhesion GO:0007159 9.61 ICAM1 CCL5
23 eosinophil chemotaxis GO:0048245 9.61 CCL5 CCL2 CCL11
24 macrophage chemotaxis GO:0048246 9.58 CCL5 CCL2
25 positive regulation of immunoglobulin secretion GO:0051024 9.58 IL6 IL5
26 monocyte chemotaxis GO:0002548 9.46 IL6 CCL5 CCL2 CCL11
27 inflammatory response GO:0006954 9.43 IL6 IL5 CXCR3 CCL5 CCL2 CCL11
28 cytokine-mediated signaling pathway GO:0019221 9.1 IL6 IL5 ICAM1 CCL5 CCL2 CCL11

Molecular functions related to Chronic Eosinophilic Pneumonia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine activity GO:0008009 9.33 CCL5 CCL2 CCL11
2 CCR chemokine receptor binding GO:0048020 9.13 CCL5 CCL2 CCL11
3 cytokine activity GO:0005125 9.02 IL6 IL5 CCL5 CCL2 CCL11

Sources for Chronic Eosinophilic Pneumonia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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