MCID: CHR037
MIFTS: 49

Chronic Eosinophilic Pneumonia

Categories: Blood diseases, Immune diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Chronic Eosinophilic Pneumonia

MalaCards integrated aliases for Chronic Eosinophilic Pneumonia:

Name: Chronic Eosinophilic Pneumonia 12 53 59 15
Cryptogenic Pulmonary Eosinophilia 12 73
Carrington Syndrome 53 73
Eosinophilic Idiopathic Chronic Pneumopathy 53
Idiopathic Eosinophilic Chronic Pneumopathy 53
Chronic Idiopathic Eosinophilic Pneumonia 53
Idiopathic Chronic Eosinophilic Pneumonia 59
Carrington's Pulmonary Eosinophilia 53
Eosinophilic Pneumonia Chronic 55
Carrington's Disease 53

Characteristics:

Orphanet epidemiological data:

59
idiopathic chronic eosinophilic pneumonia
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Iceland); Age of onset: All ages; Age of death: normal life expectancy;

Classifications:



External Ids:

Disease Ontology 12 DOID:9502
NCIt 50 C34471
Orphanet 59 ORPHA2902
ICD10 via Orphanet 34 J82
UMLS via Orphanet 74 C0008680 C2930941

Summaries for Chronic Eosinophilic Pneumonia

Disease Ontology : 12 An eosinophilic pneumonia which slowly progresses over weeks to months. Life-threatening shortness of breath can develop if the condition is not treated. Individuals are often diagnosed with asthma before the advent of this disease.

MalaCards based summary : Chronic Eosinophilic Pneumonia, also known as cryptogenic pulmonary eosinophilia, is related to eosinophilic pneumonia and pneumonia. An important gene associated with Chronic Eosinophilic Pneumonia is IL5 (Interleukin 5), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Prednisolone phosphate and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and t cells, and related phenotypes are hematopoietic system and immune system

Related Diseases for Chronic Eosinophilic Pneumonia

Diseases in the Eosinophilic Pneumonia family:

Chronic Eosinophilic Pneumonia

Diseases related to Chronic Eosinophilic Pneumonia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 164)
# Related Disease Score Top Affiliating Genes
1 eosinophilic pneumonia 31.2 CCL11 CCL5 IL5 RNASE3
2 pneumonia 31.2 CCL11 CCL2 CCL5 IL5
3 churg-strauss syndrome 30.5 IL5 RNASE3
4 pulmonary eosinophilia 30.2 CCL11 CCL5 IL5 RNASE3
5 bronchiolitis 30.1 CCL11 CCL5 IL5 RNASE3
6 bronchitis 29.8 CCL11 IL5 RNASE3
7 bullous pemphigoid 29.8 CCL11 IL5 RNASE3
8 allergic hypersensitivity disease 29.6 CCL11 CCL5 IL5 RNASE3
9 lung disease 29.2 CCL2 CCL5 CXCR3 IL5 RNASE3
10 asthma 29.1 CCL11 CCL2 CCL5 ICAM1 IL5 ITGAM
11 pemphigoid gestationis 10.2 CCL11 IL5
12 chronic meningitis 10.2 CCL11 IL5
13 angiostrongyliasis 10.2 CCL11 IL5
14 loeffler endocarditis 10.2 IL5 RNASE3
15 strongyloidiasis 10.2 CCL11 IL5
16 eosinophilic meningitis 10.2 CCL11 IL5
17 cough variant asthma 10.2 IL5 RNASE3
18 cow milk allergy 10.2 IL5 RNASE3
19 milk allergy 10.2 IL5 RNASE3
20 eosinophilic gastritis 10.2 CCL11 IL5
21 sinusitis 10.2 IL5 RNASE3
22 atopic keratoconjunctivitis 10.2 IL5 RNASE3
23 intrinsic asthma 10.2 IL5 RNASE3
24 inflammatory bowel disease 4 10.2 IL5 RNASE3
25 blepharoconjunctivitis 10.2 CCL11 RNASE3
26 latex allergy 10.2 IL5 RNASE3
27 esophagitis, eosinophilic, 1 10.2 CCL11 IL5
28 esophagitis 10.2 CCL11 IL5
29 respiratory syncytial virus infectious disease 10.2 CCL5 IL5
30 giant papillary conjunctivitis 10.2 CCL11 RNASE3
31 urinary schistosomiasis 10.2 IL5 RNASE3
32 night blindness, congenital stationary, type 1a 10.2 CCL11 IL5
33 vulvovaginitis 10.2 CCL11 CCL5
34 wells syndrome 10.2 IL5 RNASE3
35 rheumatoid arthritis 10.2
36 arthritis 10.2
37 allergic angiitis 10.2
38 maxillary sinusitis 10.1 CCL5 RNASE3
39 scleritis 10.1 CCL2 IL5
40 cellulitis 10.1 IL5 RNASE3
41 inclusion conjunctivitis 10.1 CCL5 IL5
42 japanese spotted fever 10.1 CCL11 CCL2
43 bullous skin disease 10.1 CCL5 IL5
44 pustulosis palmaris et plantaris 10.1 CXCR3 IL5
45 parasitic helminthiasis infectious disease 10.1 IL5 RNASE3
46 ige responsiveness, atopic 10.1 IL5 RNASE3
47 bronchiolitis obliterans 10.1
48 lymphoma 10.1
49 stachybotrys chartarum 10.1 CCL2 CCL5
50 orofacial granulomatosis 10.1 CCL5 CXCR3

Graphical network of the top 20 diseases related to Chronic Eosinophilic Pneumonia:



Diseases related to Chronic Eosinophilic Pneumonia

Symptoms & Phenotypes for Chronic Eosinophilic Pneumonia

MGI Mouse Phenotypes related to Chronic Eosinophilic Pneumonia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.43 CCL11 CCL5 CXCR3 ICAM1 IL5 ITGAM
2 immune system MP:0005387 9.17 CCL11 CCL2 CCL5 CXCR3 ICAM1 IL5

Drugs & Therapeutics for Chronic Eosinophilic Pneumonia

Drugs for Chronic Eosinophilic Pneumonia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
2
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
3
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
4
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
5
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
6 Antineoplastic Agents, Hormonal Phase 4
7 Anti-Inflammatory Agents Phase 4
8 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
9 Hormone Antagonists Phase 4
10 Peripheral Nervous System Agents Phase 4
11 Hormones Phase 4
12 Methylprednisolone acetate Phase 4
13 Prednisolone acetate Phase 4
14 Gastrointestinal Agents Phase 4
15 Antiemetics Phase 4
16 Autonomic Agents Phase 4
17 glucocorticoids Phase 4
18 Neuroprotective Agents Phase 4
19 Protective Agents Phase 4
20 Immunologic Factors
21 Immunoglobulins
22 Antibodies, Monoclonal
23 Antibodies

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Efficacy of Three Months-prednisolone Therapy for Chronic Eosinophilic Pneumonia Completed NCT00632554 Phase 4 prednisolone 0.5 mg/kg/day for three months;prednisolone 0.5 mg/kg/day for six months
2 Observational Study of Characteristics, Treatment and Outcomes With Severe Asthma in the United States (CHRONICLE) Recruiting NCT03373045

Search NIH Clinical Center for Chronic Eosinophilic Pneumonia

Genetic Tests for Chronic Eosinophilic Pneumonia

Anatomical Context for Chronic Eosinophilic Pneumonia

MalaCards organs/tissues related to Chronic Eosinophilic Pneumonia:

41
Bone, Lung, T Cells, Breast, Bone Marrow, Skin, Eye

Publications for Chronic Eosinophilic Pneumonia

Articles related to Chronic Eosinophilic Pneumonia:

(show top 50) (show all 165)
# Title Authors Year
1
Long-term management and persistent impairment of pulmonary function in chronic eosinophilic pneumonia: A review of the previous literature. ( 29395966 )
2018
2
Conjunctival Eosinophilic Masses With Chronic Eosinophilic Pneumonia. ( 30044249 )
2018
3
Elevated Levels of Intelectin-1, a Pathogen-binding Lectin, in the BAL Fluid of Patients with Chronic Eosinophilic Pneumonia and Hypersensitivity Pneumonitis. ( 30101907 )
2018
4
A case of chronic eosinophilic pneumonia successfully treated with mepolizumab. ( 30201098 )
2018
5
Anti-interleukin (IL)-5 as a steroid-sparing agent in chronic eosinophilic pneumonia. ( 30444149 )
2018
6
Pulmonary Actinomycosis in a Patient with Chronic Eosinophilic Pneumonia treated with Omalizumab. ( 28720253 )
2017
7
Response to Omalizumab in a Patient With Chronic Eosinophilic Pneumonia and Poor Response to Corticosteroids. ( 29258701 )
2017
8
Chronic eosinophilic pneumonia after radiation therapy for squamous cell lung cancer. ( 28831373 )
2017
9
Possible Role of IL-25 in Eosinophilic Lung Inflammation in Patients with Chronic Eosinophilic Pneumonia. ( 28875265 )
2017
10
Chronic eosinophilic pneumonia: Adjunctive therapy with inhaled steroids. ( 28626631 )
2017
11
Chronic Eosinophilic Pneumonia: A Diagnostic Challenge. ( 28694046 )
2017
12
The reversed halo sign: also think about chronic eosinophilic pneumonia. ( 29365007 )
2017
13
Persistent impairment on spirometry in chronic eosinophilic pneumonia: a longitudinal observation study (Shizuoka-CEP study). ( 28942952 )
2017
14
Chronic eosinophilic pneumonia presenting with ipsilateral pleural effusion: a case report. ( 27520469 )
2016
15
A CASE OF EOSINOPHILIC BRONCHIOLITIS COMPLICATED WITH BRONCHIAL ASTHMA AND CHRONIC EOSINOPHILIC PNEUMONIA. ( 27086960 )
2016
16
The Long-term Clinical Course of Chronic Eosinophilic Pneumonia. ( 27580536 )
2016
17
Bronchial involvement in chronic eosinophilic pneumonia: a case report. ( 25973261 )
2015
18
'Photographic negative of pulmonary oedema': a classical radiographic pattern of chronic eosinophilic pneumonia. ( 26155798 )
2015
19
Efficacy of short-term prednisolone treatment in patients with chronic eosinophilic pneumonia. ( 25614171 )
2015
20
Marked Thrombocytosis in Chronic Eosinophilic Pneumonia and Analysis of Cytokine Mechanism. ( 26490522 )
2015
21
A must diagnosis of persistent cough: chronic eosinophilic pneumonia (Carrington disease). ( 26782801 )
2015
22
Complication of chronic eosinophilic pneumonia in an elderly patient with sjAPgren syndrome. ( 25899635 )
2015
23
A chronic eosinophilic pneumonia case with long exposure to isocyanates. ( 25823164 )
2014
24
Unusual presentation of chronic eosinophilic pneumonia with "reversed halo sign": a case report. ( 25035707 )
2014
25
Case of invasive mucinous adenocarcinoma mimicking chronic eosinophilic pneumonia. ( 26766997 )
2014
26
Significance of fractional exhaled nitric oxide in chronic eosinophilic pneumonia: a retrospective cohort study. ( 24885379 )
2014
27
Chronic eosinophilic pneumonia: a paediatric case. ( 23625667 )
2013
28
Can omalizumab be effective in chronic eosinophilic pneumonia? ( 23276861 )
2013
29
Allergic Bronchopulmonary Aspergillosis Mimicking Relapsing Chronic Eosinophilic Pneumonia in Non-Asthma Patient. ( 24368582 )
2013
30
Chronic eosinophilic pneumonia with persistent decreased diffusing capacity for carbon monoxide. ( 23417937 )
2013
31
Diagnosis in just over a minute: a case of chronic eosinophilic pneumonia. ( 23297060 )
2013
32
Chronic Eosinophilic Pneumonia in a Breast Cancer Patient Post Radiation Therapy: A Case Report. ( 24026185 )
2013
33
Tracheobronchial involvement in chronic eosinophilic pneumonia. ( 23155215 )
2012
34
Omalizumab as a steroid-sparing agent in chronic eosinophilic pneumonia. ( 22871762 )
2012
35
Chronic eosinophilic pneumonia presenting with acute onset. ( 23393913 )
2012
36
Chronic eosinophilic pneumonia: autoimmune phenomenon or immunoallergic disease? Case report and literature review. ( 22196999 )
2012
37
Pulmonary cavity due to chronic eosinophilic pneumonia associated with arsenicosis. ( 23279770 )
2012
38
Chronic eosinophilic pneumonia due to radiographic contrast administration: an orphan disease? ( 23251088 )
2012
39
Successful treatment of chronic eosinophilic pneumonia with anti-IgE therapy. ( 23091327 )
2012
40
Chronic eosinophilic pneumonia with subpleural curvilinear shadow. ( 21542424 )
2011
41
Eosinophils and macrophages are involved in nitrosative stress in chronic eosinophilic pneumonia. ( 21440081 )
2011
42
Chronic eosinophilic pneumonia with endobronchial involvement. ( 23208577 )
2011
43
Churg-Strauss syndrome versus chronic eosinophilic pneumonia on high-resolution computed tomographic findings. ( 20118716 )
2010
44
Chronic eosinophilic pneumonia with mucous plugs in a child. ( 20632404 )
2010
45
Chronic eosinophilic pneumonia (Carrington's disease) and rheumatoid arthritis. ( 20627791 )
2010
46
Chronic eosinophilic pneumonia associated with neurofibromatosis type 1: an unusual complication. ( 19262016 )
2009
47
Chronic eosinophilic pneumonia: a case report and review of the literature. ( 19830005 )
2009
48
An association of idiopathic chronic eosinophilic pneumonia with pemphigoid nodularis: a rare variant of bullous pemphigoid. ( 19917977 )
2009
49
Diffuse idiopathic pulmonary neuroendocrine hyperplasia, chronic eosinophilic pneumonia, and asthma. ( 19948916 )
2009
50
Chronic eosinophilic pneumonia secondary to long-term use of nitrofurantoin: high-resolution computed tomography findings. ( 18392467 )
2008

Variations for Chronic Eosinophilic Pneumonia

Expression for Chronic Eosinophilic Pneumonia

Search GEO for disease gene expression data for Chronic Eosinophilic Pneumonia.

Pathways for Chronic Eosinophilic Pneumonia

Pathways related to Chronic Eosinophilic Pneumonia according to GeneCards Suite gene sharing:

(show all 35)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.72 CCL11 CCL2 CCL5 ICAM1 IL5 ITGAM
2
Show member pathways
13.58 CCL11 CCL2 CCL5 CXCR3 IL5 ITGAM
3
Show member pathways
13.26 CCL11 CCL2 CCL5 ICAM1 IL5 ITGAM
4
Show member pathways
13.12 CCL11 CCL2 CCL5 CXCR3 IL5 ITGAM
5
Show member pathways
13.09 CCL11 CCL2 CCL5 CXCR3 ICAM1 ITGAM
6
Show member pathways
13.04 CCL11 CCL2 CCL5 ICAM1 IL5 ITGAM
7
Show member pathways
13.03 CCL11 CCL2 CCL5 CXCR3 IL5
8
Show member pathways
12.66 CCL11 CCL2 CCL5 CXCR3
9
Show member pathways
12.65 CCL11 ICAM1 IL5 RNASE3
10
Show member pathways
12.15 CCL11 CCL5 ICAM1
11
Show member pathways
12.13 CCL2 CCL5 ICAM1
12
Show member pathways
12.13 CCL11 CCL2 IL5
13 11.78 CCL2 CCL5 ICAM1
14
Show member pathways
11.73 CCL11 CCL2 CCL5 ICAM1 IL5
15 11.67 CCL2 CCL5 ICAM1
16
Show member pathways
11.62 CCL11 CCL2 CCL5 CXCR3
17 11.6 CXCR3 IL5 ITGAM
18 11.54 CCL11 CCL2 CCL5
19
Show member pathways
11.54 CCL11 CCL2 CCL5 CXCR3 ICAM1 ITGAM
20 11.51 CCL11 CCL2 ICAM1 ITGAM
21 11.47 CCL11 IL5
22 11.41 ICAM1 ITGAM
23 11.35 CCL2 ICAM1
24 11.34 ICAM1 ITGAM
25 11.33 CCL2 ITGAM
26 11.31 CCL11 IL5
27 11.3 CCL2 CCL5 ICAM1
28 11.29 ICAM1 ITGAM
29 11.16 CCL11 CXCR3
30 11.01 CCL2 ICAM1
31 10.9 CCL11 CCL2 CCL5 IL5
32 10.87 CCL11 CCL2
33 10.78 CCL2 ICAM1
34 10.72 CCL11 CCL2 CCL5 IL5
35 10.71 CCL11 CCL2 CCL5 IL5 ITGAM

GO Terms for Chronic Eosinophilic Pneumonia

Cellular components related to Chronic Eosinophilic Pneumonia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.17 CCL11 CCL2 CCL5 ICAM1 IL5 ITGAM
2 external side of plasma membrane GO:0009897 9.13 CXCR3 ICAM1 ITGAM

Biological processes related to Chronic Eosinophilic Pneumonia according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.91 CCL11 CCL2 CXCR3 ICAM1 ITGAM
2 immune response GO:0006955 9.88 CCL11 CCL2 CCL5 CXCR3 IL5
3 regulation of signaling receptor activity GO:0010469 9.87 CCL11 CCL2 CCL5 IL5
4 positive regulation of GTPase activity GO:0043547 9.85 CCL11 CCL2 CCL5 ICAM1
5 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.83 CCL11 CCL2 CCL5 ICAM1
6 MAPK cascade GO:0000165 9.78 CCL2 CCL5 IL5
7 inflammatory response GO:0006954 9.77 CCL11 CCL2 CCL5 CXCR3 IL5
8 regulation of cell shape GO:0008360 9.76 CCL11 CCL2 ICAM1
9 cell chemotaxis GO:0060326 9.73 CCL2 CCL5 CXCR3
10 chemotaxis GO:0006935 9.73 CCL11 CCL2 CCL5 CXCR3
11 neutrophil chemotaxis GO:0030593 9.71 CCL11 CCL2 CCL5
12 cellular response to tumor necrosis factor GO:0071356 9.71 CCL11 CCL2 CCL5 ICAM1
13 monocyte chemotaxis GO:0002548 9.67 CCL11 CCL2 CCL5
14 positive regulation of actin filament polymerization GO:0030838 9.63 CCL11 ICAM1
15 lymphocyte chemotaxis GO:0048247 9.63 CCL11 CCL2 CCL5
16 protein kinase B signaling GO:0043491 9.62 CCL2 CCL5
17 lipopolysaccharide-mediated signaling pathway GO:0031663 9.62 CCL2 CCL5
18 cellular response to fibroblast growth factor stimulus GO:0044344 9.61 CCL2 CCL5
19 leukocyte cell-cell adhesion GO:0007159 9.6 CCL5 ICAM1
20 positive regulation of JAK-STAT cascade GO:0046427 9.59 CCL5 IL5
21 macrophage chemotaxis GO:0048246 9.58 CCL2 CCL5
22 cellular response to interferon-gamma GO:0071346 9.56 CCL11 CCL2 CCL5 ICAM1
23 eosinophil chemotaxis GO:0048245 9.5 CCL11 CCL2 CCL5
24 cellular response to interleukin-1 GO:0071347 9.46 CCL11 CCL2 CCL5 ICAM1
25 chemokine-mediated signaling pathway GO:0070098 9.26 CCL11 CCL2 CCL5 CXCR3
26 cytokine-mediated signaling pathway GO:0019221 9.1 CCL11 CCL2 CCL5 ICAM1 IL5 ITGAM

Molecular functions related to Chronic Eosinophilic Pneumonia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine activity GO:0008009 9.33 CCL11 CCL2 CCL5
2 cytokine activity GO:0005125 9.26 CCL11 CCL2 CCL5 IL5
3 CCR chemokine receptor binding GO:0048020 8.8 CCL11 CCL2 CCL5

Sources for Chronic Eosinophilic Pneumonia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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