MCID: CHR053
MIFTS: 29

Chronic Follicular Conjunctivitis

Categories: Eye diseases

Aliases & Classifications for Chronic Follicular Conjunctivitis

MalaCards integrated aliases for Chronic Follicular Conjunctivitis:

Name: Chronic Follicular Conjunctivitis 12 15 72

Classifications:



External Ids:

Disease Ontology 12 DOID:13326
ICD9CM 35 372.12
SNOMED-CT 68 39429002
ICD10 33 H10.43
UMLS 72 C0155147

Summaries for Chronic Follicular Conjunctivitis

MalaCards based summary : Chronic Follicular Conjunctivitis is related to chlamydia and conjunctivitis. An important gene associated with Chronic Follicular Conjunctivitis is IL1A (Interleukin 1 Alpha), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Allograft rejection. Affiliated tissues include eye and testes, and related phenotypes are Decreased Tat-dependent HIV-LTR-beta-galactosidase protein expression and cardiovascular system

Related Diseases for Chronic Follicular Conjunctivitis

Diseases related to Chronic Follicular Conjunctivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 73)
# Related Disease Score Top Affiliating Genes
1 chlamydia 30.3 IL1B IL1A
2 conjunctivitis 10.4
3 cryptosporidiosis 10.2 IL1A CD40LG
4 immune deficiency disease 10.1 IL1A CD40LG
5 irritant dermatitis 10.1 IL1B IL1A
6 stachybotrys chartarum 10.1 IL1B IL1A
7 meningococcemia 10.1 IL1B IL1A
8 limbal stem cell deficiency 10.1 IL1B IL1A
9 gingival disease 10.1 IL1B IL1A
10 pulpitis 10.1 IL1B IL1A
11 root resorption 10.1 IL1B IL1A
12 keratoconjunctivitis sicca 10.1 IL1B IL1A
13 somatoform disorder 10.0 IL1B IL1A
14 bacterial vaginosis 10.0 IL1B IL1A
15 tonsillitis 10.0 IL1B IL1A
16 silicosis 10.0 IL1B IL1A
17 aggressive periodontitis 10.0 IL1B IL1A
18 contact dermatitis 10.0 IL1B IL1A
19 osteomyelitis 10.0 IL1B IL1A
20 bone inflammation disease 10.0 IL1B IL1A
21 toxoplasmosis 9.9 IL1B CD40LG
22 graft-versus-host disease 9.9 IL1B IL1A
23 pertussis 9.9 IL1B IL1A
24 chlamydia pneumonia 9.9
25 follicular lymphoma 9.9
26 lymphoma 9.9
27 ptosis 9.9
28 trachoma 9.9
29 inclusion conjunctivitis 9.9
30 rhinosporidiosis 9.9
31 chronic conjunctivitis 9.9
32 leishmaniasis 9.9 IL1B IL1A
33 rheumatic disease 9.9 IL1B CD40LG
34 epithelial basement membrane dystrophy 9.9 MMP9 IL1A
35 pelvic inflammatory disease 9.9 MMP9 CD40LG
36 fatty liver disease 9.8 IL1B IL1A
37 secondary progressive multiple sclerosis 9.8 MMP9 CD40LG
38 viral infectious disease 9.8 IL1B CD40LG
39 cholesteatoma of middle ear 9.8 MMP9 IL1A
40 pulmonary fibrosis 9.8 MMP9 IL1B
41 pneumonia 9.8 IL1B CD40LG
42 corneal ulcer 9.8 MMP9 IL1B
43 central nervous system tuberculosis 9.8 MMP9 IL1B
44 preterm premature rupture of the membranes 9.8 MMP9 IL1B
45 appendicitis 9.8 MMP9 IL1B
46 keratitis, hereditary 9.7 MMP9 IL1B
47 bacterial meningitis 9.7 MMP9 IL1B
48 meningitis 9.7 MMP9 IL1B
49 psoriatic arthritis 9.7 IL1B IL1A
50 brain edema 9.7 MMP9 IL1B

Graphical network of the top 20 diseases related to Chronic Follicular Conjunctivitis:



Diseases related to Chronic Follicular Conjunctivitis

Symptoms & Phenotypes for Chronic Follicular Conjunctivitis

GenomeRNAi Phenotypes related to Chronic Follicular Conjunctivitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased Tat-dependent HIV-LTR-beta-galactosidase protein expression GR00224-A-2 8.62 IL1A MMP9

MGI Mouse Phenotypes related to Chronic Follicular Conjunctivitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.46 CD40LG IL1A IL1B MMP9
2 integument MP:0010771 9.26 CD40LG IL1A IL1B MMP9
3 neoplasm MP:0002006 8.8 IL1A IL1B MMP9

Drugs & Therapeutics for Chronic Follicular Conjunctivitis

Search Clinical Trials , NIH Clinical Center for Chronic Follicular Conjunctivitis

Genetic Tests for Chronic Follicular Conjunctivitis

Anatomical Context for Chronic Follicular Conjunctivitis

MalaCards organs/tissues related to Chronic Follicular Conjunctivitis:

41
Eye, Testes

Publications for Chronic Follicular Conjunctivitis

Articles related to Chronic Follicular Conjunctivitis:

(show all 33)
# Title Authors PMID Year
1
Chronic Follicular Conjunctivitis in a Middle-aged Woman. 38
29801089 2018
2
Follicular Conjunctivitis due to Chlamydia felis-Case Report, Review of the Literature and Improved Molecular Diagnostics. 38
28770201 2017
3
Follicular Lymphoma Presenting Solely as Chronic Follicular Conjunctivitis. 38
26606298 2016
4
Primary conjunctival follicular lymphoma mimicking chronic conjunctivitis. 38
26560164 2016
5
Topical Cyclosporine A 1% for the Treatment of Chronic Follicular Conjunctivitis. 38
25503906 2015
6
Topical cyclosporine a 1% for the treatment of chronic ocular surface inflammation. 38
25083780 2014
7
Chlamydia trachomatis conjunctivitis in a male teenager: a case report. 38
24955802 2014
8
Ocular rhinosporidiosis presenting as chronic follicular conjunctivitis in a contact lens wearer. 38
19667358 2009
9
[Trachoma: epidemiologic study in students in Alagoas State--Brazil]. 38
19668966 2009
10
[Newborn chronic follicular conjunctivitis]. 38
18803130 2008
11
Topical tacrolimus ointment for treatment of refractory anterior segment inflammatory disorders. 38
15829797 2005
12
Follicular conjunctivitis caused by a mantle cell lymphoma. 38
15162290 2004
13
Current trachoma treatment methodologies: focus on advancements in drug therapy. 38
12465997 2002
14
Immunology of trachomatous conjunctivitis. 38
11486468 2001
15
Prevalence of Chlamydia trachomatis pooled serotypes BDE and FGK in children with chronic follicular conjunctivitis. 38
11033122 2000
16
Diagnosis of chlamydial infection by direct enzyme-linked immunoassay and polymerase chain reaction in patients with acute follicular conjunctivitis. 38
10459609 1999
17
Chronic follicular conjunctivitis associated with Chlamydia psittaci or Chlamydia pneumoniae. 38
9636859 1998
18
Immunopathogenesis of conjunctival scarring in trachoma. 38
9775249 1998
19
Evaluation of two nonculture antigen tests and three serotests for detection of anti-chlamydial antibodies in the diagnosis of ocular chlamydial infections. 38
8858357 1996
20
[Recurrent canaliculitis and dacryocystitis as a sequela of persistent infection with Chlamydia trachomatis]. 38
8443442 1993
21
Experimental conjunctival infection of lambs with a strain of Chlamydia psittaci isolated from the eyes of a sheep naturally affected with keratoconjunctivitis. 38
2260264 1990
22
Treatment of periorbital Molluscum contagiosum by incision and curettage. 38
3399259 1988
23
The diagnosis and treatment of chlamydial conjunctivitis. 38
3068171 1988
24
Moraxella lacunata isolated from epidemic conjunctivitis among teen-aged females. 38
3901656 1985
25
Laboratory studies in chronic conjunctivitis. 38
6660697 1983
26
An animal model of trachoma II. The importance of repeated reinfection. 38
6749750 1982
27
An animal model for cicatrizing trachoma. 38
7275529 1981
28
Isolation of a Chlamydia-like agent in essential conjunctival atrophy and chronic follicular conjunctivitis. 38
4332001 1971
29
Chronic follicular conjunctivitis and its etiological agent. 38
5742668 1968
30
A new type of chronic follicular conjunctivitis with corneal changes. 38
6025164 1967
31
Bacteriological studies on trachomatous and normal persons from three areas on Taiwan. 38
20604116 1962
32
[Comparative study of the origin of chronic follicular conjunctivitis]. 38
14434412 1959
33
Etiology and differential diagnosis of non-trachomatous follicular conjunctivitis. 38
13472441 1957

Variations for Chronic Follicular Conjunctivitis

Expression for Chronic Follicular Conjunctivitis

Search GEO for disease gene expression data for Chronic Follicular Conjunctivitis.

Pathways for Chronic Follicular Conjunctivitis

Pathways related to Chronic Follicular Conjunctivitis according to GeneCards Suite gene sharing:

(show all 38)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.89 MMP9 IL1B IL1A CD40LG
2
Show member pathways
12.55 IL1B IL1A CD40LG
3
Show member pathways
12.34 IL1B IL1A CD40LG
4
Show member pathways
12.33 IL1B IL1A CD40LG
5
Show member pathways
12.28 IL1B IL1A CD40LG
6
Show member pathways
12.15 IL1B IL1A CD40LG
7
Show member pathways
11.9 MMP9 IL1B IL1A
8 11.89 IL1B IL1A
9
Show member pathways
11.85 IL1B IL1A CD40LG
10 11.78 IL1B IL1A
11
Show member pathways
11.77 MMP9 IL1B
12
Show member pathways
11.76 IL1B IL1A
13 11.71 MMP9 IL1B
14 11.68 IL1B IL1A
15 11.66 IL1B CD40LG
16 11.65 IL1B IL1A
17 11.64 IL1B IL1A
18 11.64 MMP9 IL1B IL1A
19 11.61 IL1B IL1A
20 11.55 IL1B IL1A
21 11.51 IL1B IL1A
22 11.47 MMP9 IL1B
23 11.41 MMP9 IL1B IL1A
24 11.4 MMP9 IL1B
25 11.29 IL1B CD40LG
26 11.28 IL1B IL1A
27 11.27 IL1B IL1A
28 11.22 IL1B IL1A
29 11.19 MMP9 IL1B IL1A
30 11.08 IL1B IL1A
31 11.07 IL1B IL1A
32 11.02 MMP9 CD40LG
33 10.96 IL1B IL1A
34 10.85 MMP9 IL1B
35 10.77 IL1B IL1A CD40LG
36
Show member pathways
10.72 MMP9 IL1B IL1A CD40LG
37 10.69 IL1B IL1A CD40LG
38 10.1 IL1B IL1A

GO Terms for Chronic Follicular Conjunctivitis

Cellular components related to Chronic Follicular Conjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.26 MMP9 IL1B IL1A CD40LG
2 extracellular space GO:0005615 8.92 MMP9 IL1B IL1A CD40LG

Biological processes related to Chronic Follicular Conjunctivitis according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.7 IL1B IL1A CD40LG
2 inflammatory response GO:0006954 9.63 IL1B IL1A CD40LG
3 positive regulation of angiogenesis GO:0045766 9.56 IL1B IL1A
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.55 IL1B CD40LG
5 positive regulation of T cell proliferation GO:0042102 9.54 IL1B CD40LG
6 interleukin-1-mediated signaling pathway GO:0070498 9.51 IL1B IL1A
7 positive regulation of cell division GO:0051781 9.49 IL1B IL1A
8 embryo implantation GO:0007566 9.48 MMP9 IL1B
9 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.43 IL1B IL1A
10 cytokine-mediated signaling pathway GO:0019221 9.43 MMP9 IL1B IL1A
11 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.4 IL1B IL1A
12 positive regulation of vascular endothelial growth factor production GO:0010575 9.37 IL1B IL1A
13 positive regulation of mitotic nuclear division GO:0045840 9.32 IL1B IL1A
14 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.16 IL1B IL1A
15 ectopic germ cell programmed cell death GO:0035234 8.96 IL1B IL1A
16 fever generation GO:0001660 8.62 IL1B IL1A

Molecular functions related to Chronic Follicular Conjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.13 IL1B IL1A CD40LG
2 interleukin-1 receptor binding GO:0005149 8.62 IL1B IL1A

Sources for Chronic Follicular Conjunctivitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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