MCID: CHR053
MIFTS: 29

Chronic Follicular Conjunctivitis

Categories: Eye diseases

Aliases & Classifications for Chronic Follicular Conjunctivitis

MalaCards integrated aliases for Chronic Follicular Conjunctivitis:

Name: Chronic Follicular Conjunctivitis 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:13326
ICD10 33 H10.43
ICD9CM 35 372.12
SNOMED-CT 68 39429002
UMLS 73 C0155147

Summaries for Chronic Follicular Conjunctivitis

MalaCards based summary : Chronic Follicular Conjunctivitis is related to chlamydia and conjunctivitis. An important gene associated with Chronic Follicular Conjunctivitis is IL1A (Interleukin 1 Alpha), and among its related pathways/superpathways are IL-1 Family Signaling Pathways and Necroptosis. Affiliated tissues include eye, lung and brain, and related phenotypes are Decreased Tat-dependent HIV-LTR-beta-galactosidase protein expression and neoplasm

Related Diseases for Chronic Follicular Conjunctivitis

Diseases related to Chronic Follicular Conjunctivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Related Disease Score Top Affiliating Genes
1 chlamydia 30.2 IL1A IL1B
2 conjunctivitis 10.4
3 irritant dermatitis 10.0 IL1A IL1B
4 stachybotrys chartarum 10.0 IL1A IL1B
5 limbal stem cell deficiency 10.0 IL1A IL1B
6 meningococcemia 10.0 IL1A IL1B
7 gingival disease 10.0 IL1A IL1B
8 pulpitis 10.0 IL1A IL1B
9 root resorption 10.0 IL1A IL1B
10 malignant histiocytosis 10.0 IL1A IL1B
11 keratoconjunctivitis sicca 10.0 IL1A IL1B
12 idiopathic neutropenia 10.0 IL1A IL1B
13 bacterial vaginosis 10.0 IL1A IL1B
14 somatoform disorder 10.0 IL1A IL1B
15 silicosis 10.0 IL1A IL1B
16 tonsillitis 10.0 IL1A IL1B
17 aggressive periodontitis 10.0 IL1A IL1B
18 contact dermatitis 10.0 IL1A IL1B
19 osteomyelitis 10.0 IL1A IL1B
20 bone inflammation disease 10.0 IL1A IL1B
21 graft-versus-host disease 10.0 IL1A IL1B
22 alopecia areata 10.0 IL1A IL1B
23 pertussis 10.0 IL1A IL1B
24 epithelial basement membrane dystrophy 10.0 IL1A MMP9
25 cholesteatoma of middle ear 9.9 IL1A MMP9
26 pulmonary fibrosis 9.9 IL1B MMP9
27 fatty liver disease 9.9 IL1A IL1B
28 corneal ulcer 9.9 IL1B MMP9
29 central nervous system tuberculosis 9.9 IL1B MMP9
30 psoriatic arthritis 9.9 IL1A IL1B
31 preterm premature rupture of the membranes 9.9 IL1B MMP9
32 appendicitis 9.9 IL1B MMP9
33 keratitis, hereditary 9.9 IL1B MMP9
34 lyme disease 9.9 IL1B MMP9
35 bacterial meningitis 9.9 IL1B MMP9
36 meningitis 9.9 IL1B MMP9
37 leishmaniasis 9.9 IL1A IL1B
38 follicular lymphoma 9.9
39 lymphoma 9.9
40 rhinosporidiosis 9.9
41 brain edema 9.9 IL1B MMP9
42 stomach disease 9.9 IL1B MMP9
43 aortic aneurysm, familial abdominal, 1 9.9 IL1B MMP9
44 arteries, anomalies of 9.9 IL1B MMP9
45 respiratory system disease 9.8 IL1B MMP9
46 demyelinating disease 9.8 IL1B MMP9
47 gastrointestinal system disease 9.8 IL1B MMP9
48 nervous system disease 9.8 IL1B MMP9
49 intervertebral disc disease 9.7 IL1A IL1B MMP9
50 chorioamnionitis 9.7 IL1A IL1B MMP9

Graphical network of the top 20 diseases related to Chronic Follicular Conjunctivitis:



Diseases related to Chronic Follicular Conjunctivitis

Symptoms & Phenotypes for Chronic Follicular Conjunctivitis

GenomeRNAi Phenotypes related to Chronic Follicular Conjunctivitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased Tat-dependent HIV-LTR-beta-galactosidase protein expression GR00224-A-2 8.62 IL1A MMP9

MGI Mouse Phenotypes related to Chronic Follicular Conjunctivitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 8.8 IL1A IL1B MMP9

Drugs & Therapeutics for Chronic Follicular Conjunctivitis

Search Clinical Trials , NIH Clinical Center for Chronic Follicular Conjunctivitis

Genetic Tests for Chronic Follicular Conjunctivitis

Anatomical Context for Chronic Follicular Conjunctivitis

MalaCards organs/tissues related to Chronic Follicular Conjunctivitis:

41
Eye, Lung, Brain, Liver, Bone, Tonsil

Publications for Chronic Follicular Conjunctivitis

Articles related to Chronic Follicular Conjunctivitis:

# Title Authors Year
1
Chronic Follicular Conjunctivitis in a Middle-aged Woman. ( 29801089 )
2018
2
Follicular Lymphoma Presenting Solely as Chronic Follicular Conjunctivitis. ( 26606298 )
2016
3
Topical Cyclosporine A 1% for the Treatment of Chronic Follicular Conjunctivitis. ( 25503906 )
2014
4
Ocular rhinosporidiosis presenting as chronic follicular conjunctivitis in a contact lens wearer. ( 19667358 )
2009
5
Prevalence of Chlamydia trachomatis pooled serotypes BDE and FGK in children with chronic follicular conjunctivitis. ( 11033122 )
2000
6
Chronic follicular conjunctivitis associated with Chlamydia psittaci or Chlamydia pneumoniae. ( 9636859 )
1998
7
Isolation of a Chlamydia-like agent in essential conjunctival atrophy and chronic follicular conjunctivitis. ( 4332001 )
1971
8
Chronic follicular conjunctivitis and its etiological agent. ( 5742668 )
1968
9
A new type of chronic follicular conjunctivitis with corneal changes. ( 6025164 )
1967

Variations for Chronic Follicular Conjunctivitis

Expression for Chronic Follicular Conjunctivitis

Search GEO for disease gene expression data for Chronic Follicular Conjunctivitis.

Pathways for Chronic Follicular Conjunctivitis

Pathways related to Chronic Follicular Conjunctivitis according to GeneCards Suite gene sharing:

(show all 28)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.88 IL1A IL1B
2
Show member pathways
11.87 IL1A IL1B
3 11.84 IL1A IL1B
4
Show member pathways
11.82 IL1A IL1B MMP9
5 11.73 IL1A IL1B
6
Show member pathways
11.72 IL1B MMP9
7
Show member pathways
11.7 IL1A IL1B
8 11.65 IL1B MMP9
9 11.64 IL1A IL1B MMP9
10 11.62 IL1A IL1B
11 11.59 IL1A IL1B
12 11.57 IL1A IL1B
13 11.53 IL1A IL1B
14 11.5 IL1A IL1B
15 11.44 IL1A IL1B
16 11.41 IL1A IL1B MMP9
17 11.4 IL1B MMP9
18 11.32 IL1B MMP9
19 11.2 IL1A IL1B
20 11.19 IL1A IL1B MMP9
21 11.18 IL1A IL1B
22 11.13 IL1A IL1B
23 11 IL1A IL1B
24 10.98 IL1A IL1B
25 10.87 IL1A IL1B
26 10.77 IL1B MMP9
27
Show member pathways
10.6 IL1A IL1B MMP9
28 10.1 IL1A IL1B

GO Terms for Chronic Follicular Conjunctivitis

Biological processes related to Chronic Follicular Conjunctivitis according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of angiogenesis GO:0045766 9.51 IL1A IL1B
2 interleukin-1-mediated signaling pathway GO:0070498 9.49 IL1A IL1B
3 positive regulation of cell division GO:0051781 9.48 IL1A IL1B
4 embryo implantation GO:0007566 9.46 IL1B MMP9
5 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.43 IL1A IL1B
6 cytokine-mediated signaling pathway GO:0019221 9.43 IL1A IL1B MMP9
7 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.4 IL1A IL1B
8 positive regulation of mitotic nuclear division GO:0045840 9.37 IL1A IL1B
9 positive regulation of vascular endothelial growth factor production GO:0010575 9.32 IL1A IL1B
10 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.16 IL1A IL1B
11 ectopic germ cell programmed cell death GO:0035234 8.96 IL1A IL1B
12 fever generation GO:0001660 8.62 IL1A IL1B

Molecular functions related to Chronic Follicular Conjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 interleukin-1 receptor binding GO:0005149 8.62 IL1A IL1B

Sources for Chronic Follicular Conjunctivitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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