MCID: CHR017
MIFTS: 32

Chronic Gonococcal Salpingitis

Categories: Reproductive diseases

Aliases & Classifications for Chronic Gonococcal Salpingitis

MalaCards integrated aliases for Chronic Gonococcal Salpingitis:

Name: Chronic Gonococcal Salpingitis 12 15 74
Gonococcal Salpingitis 12 74

Classifications:



External Ids:

Disease Ontology 12 DOID:12718
ICD9CM 36 098.37
SNOMED-CT 69 53529004

Summaries for Chronic Gonococcal Salpingitis

Disease Ontology : 12 A chronic salpingitis that is caused by gonorrhea.

MalaCards based summary : Chronic Gonococcal Salpingitis, also known as gonococcal salpingitis, is related to acute gonococcal salpingitis and salpingitis. An important gene associated with Chronic Gonococcal Salpingitis is BLK (BLK Proto-Oncogene, Src Family Tyrosine Kinase), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Human cytomegalovirus infection. Affiliated tissues include skin, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Related Diseases for Chronic Gonococcal Salpingitis

Diseases in the Acute Gonococcal Salpingitis family:

Chronic Gonococcal Salpingitis

Diseases related to Chronic Gonococcal Salpingitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 41)
# Related Disease Score Top Affiliating Genes
1 acute gonococcal salpingitis 34.2 CTSA TNF
2 salpingitis 10.7
3 pericoronitis 10.2 TNFRSF1A TNFRSF1B
4 autoimmune myocarditis 10.2 TNF TNFRSF1A
5 sciatic neuropathy 10.2 TNFRSF1A TNFRSF1B
6 short-rib thoracic dysplasia 5 with or without polydactyly 10.2 TNFRSF1A TNFRSF1B
7 retinitis pigmentosa 75 10.2 TNF TNFRSF1A
8 skin sarcoidosis 10.2 TNF TNFRSF1B
9 juvenile ankylosing spondylitis 10.2 TNF TNFRSF1B
10 granulomatous dermatitis 10.2 TNF TNFRSF1B
11 relapsing fever 10.2 TNF TNFRSF1A
12 scleral disease 10.2 TNF TNFRSF1B
13 dystrophinopathies 10.2 TNF TNFRSF1A
14 pustulosis of palm and sole 10.2 TNF TNFRSF1B
15 peroneal neuropathy 10.2 TNF TNFRSF1B
16 spondylarthropathy 10.2 TNF TNFRSF1A
17 conjunctival disease 10.1 TNF TNFRSF1A
18 appendicitis 10.1
19 adult-onset still's disease 10.1 TNF TNFRSF1A
20 panuveitis 10.1 TNF TNFRSF1B
21 cogan syndrome 10.1 TNF TNFRSF1B
22 melkersson-rosenthal syndrome 10.1 TNF TNFRSF1B
23 hypersensitivity reaction type iv disease 10.1 TNF TNFRSF1B
24 exanthem 10.1 TNF TNFRSF1B
25 pericarditis 10.1 TNF TNFRSF1A
26 uveal disease 10.1 TNF TNFRSF1B
27 mumps 10.0 TNF TNFRSF1A
28 spondyloarthropathy 1 10.0 TNF TNFRSF1B
29 periodic fever, familial, autosomal dominant 10.0 TNF TNFRSF1A TNFRSF1B
30 post-transplant lymphoproliferative disease 10.0 TNF TNFRSF1A TNFRSF1B
31 palindromic rheumatism 10.0 TNF TNFRSF1A TNFRSF1B
32 guillain-barre syndrome 10.0 TNF TNFRSF1A TNFRSF1B
33 psoriatic arthritis 10.0 TNF TNFRSF1A TNFRSF1B
34 primary bacterial infectious disease 10.0 TNF TNFRSF1B
35 behcet syndrome 9.9 TNF TNFRSF1A TNFRSF1B
36 familial mediterranean fever 9.9 TNF TNFRSF1A
37 leukocyte disease 9.7 MCL1 TNF
38 lymphoma, non-hodgkin, familial 9.6 BAK1 MCL1 TNFRSF1A
39 systemic lupus erythematosus 9.6 BLK TNF TNFRSF1A TNFRSF1B
40 acute salpingitis 8.2 BAK1 BLK CLEC2A CTSA HRK MCL1
41 chronic salpingitis 8.2 BAK1 BLK CLEC2A CTSA HRK MCL1

Graphical network of the top 20 diseases related to Chronic Gonococcal Salpingitis:



Diseases related to Chronic Gonococcal Salpingitis

Symptoms & Phenotypes for Chronic Gonococcal Salpingitis

GenomeRNAi Phenotypes related to Chronic Gonococcal Salpingitis according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.64 HRK MCL1 TNF TNFRSF1A TNFRSF1B
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.64 HRK MCL1 TNF TNFRSF1A TNFRSF1B BAK1

MGI Mouse Phenotypes related to Chronic Gonococcal Salpingitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.8 BAK1 BLK MCL1 TNF TNFRSF1A TNFRSF1B
2 hematopoietic system MP:0005397 9.8 BAK1 BLK CTSA MCL1 TNF TNFRSF1A
3 immune system MP:0005387 9.7 BAK1 BLK CTSA MCL1 TNF TNFRSF1A
4 integument MP:0010771 9.35 CTSA MCL1 TNF TNFRSF1A TNFRSF1B
5 reproductive system MP:0005389 9.1 BAK1 BLK CTSA MCL1 TNF TNFRSF1A

Drugs & Therapeutics for Chronic Gonococcal Salpingitis

Search Clinical Trials , NIH Clinical Center for Chronic Gonococcal Salpingitis

Genetic Tests for Chronic Gonococcal Salpingitis

Anatomical Context for Chronic Gonococcal Salpingitis

MalaCards organs/tissues related to Chronic Gonococcal Salpingitis:

42
Skin

Publications for Chronic Gonococcal Salpingitis

Articles related to Chronic Gonococcal Salpingitis:

(show all 17)
# Title Authors Year
1
"Therapeutic window" in acute gonococcal salpingitis. ( 18476018 )
1995
2
Antibodies to opacity proteins (Opa) correlate with a reduced risk of gonococcal salpingitis. ( 8163673 )
1994
3
Proposed criteria for the selection of patients for ambulatory therapy of acute gonococcal salpingitis. ( 10146252 )
1993
4
Gonococcal salpingitis in a premenarchal female following sexual assault. ( 1899815 )
1991
5
Molecular mechanisms of pathogenicity of gonococcal salpingitis. ( 2873017 )
1986
6
The occurrence of chlamydial and gonococcal salpingitis during the menstrual cycle. ( 3959289 )
1986
7
Gonococcal salpingitis versus acute appendicitis: caution in diagnosis. ( 6428010 )
1984
8
Evaluation of cefamandole nafate for the treatment of acute gonococcal salpingitis. ( 6403898 )
1983
9
Gonococcal salpingitis is less likely to recur with Neisseria gonorrhoeae of the same principal outer membrane protein antigenic type. ( 6781350 )
1980
10
Recommended management of gonococcal salpingitis. ( 151678 )
1978
11
Screening for gonococcal salpingitis and penicillinase-producing gonococci. ( 64723 )
1977
12
Screening for gonococcal salpingitis. ( 63789 )
1976
13
Gonococcal salpingitis in gynaecology--myth or missed? ( 819091 )
1976
14
Hyperamylasemia associated with gonococcal salpingitis and perihepatitis. ( 940633 )
1976
15
Gonococcal salpingitis in pregnancy. ( 984115 )
1976
16
Letter: Limitations of laparoscopy in diagnosis of gonococcal salpingitis. ( 4274055 )
1974
17
Gonococcal salpingitis. ( 4981350 )
1969

Variations for Chronic Gonococcal Salpingitis

Expression for Chronic Gonococcal Salpingitis

Search GEO for disease gene expression data for Chronic Gonococcal Salpingitis.

Pathways for Chronic Gonococcal Salpingitis

Pathways related to Chronic Gonococcal Salpingitis according to GeneCards Suite gene sharing:

(show all 31)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.74 BAK1 MCL1 TNF TNFRSF1A
2
Show member pathways
12.72 BAK1 TNF TNFRSF1A TNFRSF1B
3
Show member pathways
12.71 BAK1 TNF TNFRSF1A TNFRSF1B
4
Show member pathways
12.49 BLK TNF TNFRSF1A TNFRSF1B
5 12.34 BLK TNF TNFRSF1A TNFRSF1B
6
Show member pathways
12.29 TNF TNFRSF1A TNFRSF1B
7
Show member pathways
12.28 TNF TNFRSF1A TNFRSF1B
8
Show member pathways
12.1 TNF TNFRSF1A TNFRSF1B
9
Show member pathways
12.03 BAK1 HRK MCL1 TNF TNFRSF1A TNFRSF1B
10 11.92 BAK1 MCL1 TNF TNFRSF1A TNFRSF1B
11
Show member pathways
11.87 BAK1 BLK HRK MCL1 TNF TNFRSF1A
12
Show member pathways
11.79 TNF TNFRSF1A TNFRSF1B
13 11.78 MCL1 TNF TNFRSF1B
14 11.75 TNF TNFRSF1A TNFRSF1B
15
Show member pathways
11.61 BAK1 MCL1 TNFRSF1A
16
Show member pathways
11.53 TNF TNFRSF1A TNFRSF1B
17 11.49 TNF TNFRSF1A TNFRSF1B
18 11.37 TNF TNFRSF1A TNFRSF1B
19 11.33 BLK TNF
20
Show member pathways
11.31 TNF TNFRSF1A TNFRSF1B
21 11.28 TNF TNFRSF1A
22 11.28 TNF TNFRSF1A
23 11.27 TNF TNFRSF1A TNFRSF1B
24 11.19 BAK1 MCL1
25
Show member pathways
11.18 BAK1 HRK MCL1 TNFRSF1A
26 11.16 BAK1 MCL1 TNF TNFRSF1A
27 11.13 TNFRSF1A TNFRSF1B
28 11.08 TNFRSF1A TNFRSF1B
29 11.05 TNF TNFRSF1A TNFRSF1B
30 10.95 TNF TNFRSF1A

GO Terms for Chronic Gonococcal Salpingitis

Cellular components related to Chronic Gonococcal Salpingitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 9.61 BAK1 BLK CLEC2A CTSA HRK MCL1
2 membrane raft GO:0045121 9.33 TNF TNFRSF1A TNFRSF1B
3 tumor necrosis factor receptor superfamily complex GO:0002947 8.62 TNFRSF1A TNFRSF1B

Biological processes related to Chronic Gonococcal Salpingitis according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of apoptotic process GO:0043065 9.77 BAK1 HRK TNF
2 apoptotic process GO:0006915 9.77 BAK1 HRK MCL1 TNFRSF1A TNFRSF1B
3 regulation of apoptotic process GO:0042981 9.76 BAK1 HRK MCL1
4 cytokine-mediated signaling pathway GO:0019221 9.73 MCL1 TNF TNFRSF1A TNFRSF1B
5 extrinsic apoptotic signaling pathway GO:0097191 9.59 TNF TNFRSF1B
6 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.58 MCL1 TNF
7 tumor necrosis factor-mediated signaling pathway GO:0033209 9.58 TNF TNFRSF1A TNFRSF1B
8 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.57 BAK1 MCL1
9 extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 9.56 TNF TNFRSF1A
10 positive regulation of release of cytochrome c from mitochondria GO:0090200 9.55 BAK1 HRK
11 regulation of tumor necrosis factor-mediated signaling pathway GO:0010803 9.54 TNF TNFRSF1A
12 negative regulation of cardiac muscle hypertrophy GO:0010614 9.52 TNFRSF1A TNFRSF1B
13 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.51 TNF TNFRSF1B
14 positive regulation of ceramide biosynthetic process GO:2000304 9.49 TNF TNFRSF1A
15 death-inducing signaling complex assembly GO:0071550 9.48 TNF TNFRSF1A
16 regulation of establishment of endothelial barrier GO:1903140 9.46 TNF TNFRSF1A
17 aortic valve development GO:0003176 9.32 TNFRSF1A TNFRSF1B
18 negative regulation of extracellular matrix constituent secretion GO:0003332 9.26 TNFRSF1A TNFRSF1B
19 positive regulation of apoptotic process involved in morphogenesis GO:1902339 9.16 TNFRSF1A TNFRSF1B
20 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.02 BAK1 MCL1 TNF TNFRSF1A TNFRSF1B
21 pulmonary valve development GO:0003177 8.96 TNFRSF1A TNFRSF1B

Molecular functions related to Chronic Gonococcal Salpingitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tumor necrosis factor-activated receptor activity GO:0005031 8.96 TNFRSF1A TNFRSF1B
2 tumor necrosis factor binding GO:0043120 8.62 TNFRSF1A TNFRSF1B

Sources for Chronic Gonococcal Salpingitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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