MCID: CHR017
MIFTS: 30

Chronic Gonococcal Salpingitis

Categories: Reproductive diseases

Aliases & Classifications for Chronic Gonococcal Salpingitis

MalaCards integrated aliases for Chronic Gonococcal Salpingitis:

Name: Chronic Gonococcal Salpingitis 12 15 73
Gonococcal Salpingitis 12 73

Classifications:



External Ids:

Disease Ontology 12 DOID:12718
ICD9CM 35 098.37
SNOMED-CT 68 53529004

Summaries for Chronic Gonococcal Salpingitis

MalaCards based summary : Chronic Gonococcal Salpingitis, also known as gonococcal salpingitis, is related to acute gonococcal salpingitis and salpingitis. An important gene associated with Chronic Gonococcal Salpingitis is BLK (BLK Proto-Oncogene, Src Family Tyrosine Kinase), and among its related pathways/superpathways are PI3K-Akt signaling pathway and TNFR1 Pathway. Related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Related Diseases for Chronic Gonococcal Salpingitis

Diseases in the Acute Gonococcal Salpingitis family:

Chronic Gonococcal Salpingitis

Diseases related to Chronic Gonococcal Salpingitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 33)
# Related Disease Score Top Affiliating Genes
1 acute gonococcal salpingitis 34.0 CTSA TNF
2 salpingitis 10.6
3 pericoronitis 10.4 TNFRSF1A TNFRSF1B
4 sciatic neuropathy 10.4 TNFRSF1A TNFRSF1B
5 short-rib thoracic dysplasia 5 with or without polydactyly 10.3 TNFRSF1A TNFRSF1B
6 retinitis pigmentosa 75 10.3 TNF TNFRSF1A
7 skin sarcoidosis 10.3 TNF TNFRSF1B
8 relapsing fever 10.3 TNF TNFRSF1A
9 dystrophinopathies 10.3 TNF TNFRSF1A
10 rheumatoid lung disease 10.3 TNF TNFRSF1B
11 scleral disease 10.2 TNF TNFRSF1B
12 pustulosis of palm and sole 10.2 TNF TNFRSF1B
13 peroneal neuropathy 10.2 TNF TNFRSF1B
14 sweat gland disease 10.2 TNF TNFRSF1B
15 panuveitis 10.1 TNF TNFRSF1B
16 hypersensitivity reaction type iv disease 10.1 TNF TNFRSF1B
17 exanthem 10.0 TNF TNFRSF1B
18 pericarditis 10.0 TNF TNFRSF1A
19 cogan syndrome 10.0 TNF TNFRSF1B
20 mumps 10.0 TNF TNFRSF1A
21 appendicitis 10.0
22 periodic fever, familial, autosomal dominant 9.9 TNF TNFRSF1A TNFRSF1B
23 post-transplant lymphoproliferative disease 9.9 TNF TNFRSF1A TNFRSF1B
24 palindromic rheumatism 9.9 TNF TNFRSF1A TNFRSF1B
25 guillain-barre syndrome 9.9 TNF TNFRSF1A TNFRSF1B
26 psoriatic arthritis 9.9 TNF TNFRSF1A TNFRSF1B
27 spondyloarthropathy 1 9.8 TNF TNFRSF1B
28 behcet syndrome 9.8 TNF TNFRSF1A TNFRSF1B
29 primary bacterial infectious disease 9.7 TNF TNFRSF1B
30 familial mediterranean fever 9.6 TNF TNFRSF1A
31 lymphoma, non-hodgkin, familial 9.3 BAK1 MCL1 TNFRSF1A
32 acute salpingitis 6.2 BAK1 BLK CLEC2A CTSA HRK MCL1
33 chronic salpingitis 6.2 BAK1 BLK CLEC2A CTSA HRK MCL1

Graphical network of the top 20 diseases related to Chronic Gonococcal Salpingitis:



Diseases related to Chronic Gonococcal Salpingitis

Symptoms & Phenotypes for Chronic Gonococcal Salpingitis

GenomeRNAi Phenotypes related to Chronic Gonococcal Salpingitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.64 HRK MCL1 TNF TNFRSF1A TNFRSF1B
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.64 TNFRSF1B HRK MCL1 TNF TNFRSF1A BAK1

MGI Mouse Phenotypes related to Chronic Gonococcal Salpingitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.8 BAK1 BLK MCL1 TNF TNFRSF1A TNFRSF1B
2 hematopoietic system MP:0005397 9.8 BAK1 BLK CTSA MCL1 TNF TNFRSF1A
3 immune system MP:0005387 9.7 MCL1 TNF TNFRSF1A TNFRSF1B BAK1 BLK
4 integument MP:0010771 9.35 CTSA MCL1 TNF TNFRSF1A TNFRSF1B
5 reproductive system MP:0005389 9.1 BAK1 BLK CTSA MCL1 TNF TNFRSF1A

Drugs & Therapeutics for Chronic Gonococcal Salpingitis

Search Clinical Trials , NIH Clinical Center for Chronic Gonococcal Salpingitis

Genetic Tests for Chronic Gonococcal Salpingitis

Anatomical Context for Chronic Gonococcal Salpingitis

Publications for Chronic Gonococcal Salpingitis

Articles related to Chronic Gonococcal Salpingitis:

(show all 17)
# Title Authors Year
1
"Therapeutic window" in acute gonococcal salpingitis. ( 18476018 )
1995
2
Antibodies to opacity proteins (Opa) correlate with a reduced risk of gonococcal salpingitis. ( 8163673 )
1994
3
Proposed criteria for the selection of patients for ambulatory therapy of acute gonococcal salpingitis. ( 10146252 )
1993
4
Gonococcal salpingitis in a premenarchal female following sexual assault. ( 1899815 )
1991
5
The occurrence of chlamydial and gonococcal salpingitis during the menstrual cycle. ( 3959289 )
1986
6
Molecular mechanisms of pathogenicity of gonococcal salpingitis. ( 2873017 )
1986
7
Gonococcal salpingitis versus acute appendicitis: caution in diagnosis. ( 6428010 )
1984
8
Evaluation of cefamandole nafate for the treatment of acute gonococcal salpingitis. ( 6403898 )
1983
9
Gonococcal salpingitis is less likely to recur with Neisseria gonorrhoeae of the same principal outer membrane protein antigenic type. ( 6781350 )
1980
10
Recommended management of gonococcal salpingitis. ( 151678 )
1978
11
Screening for gonococcal salpingitis and penicillinase-producing gonococci. ( 64723 )
1977
12
Screening for gonococcal salpingitis. ( 63789 )
1976
13
Gonococcal salpingitis in gynaecology--myth or missed? ( 819091 )
1976
14
Hyperamylasemia associated with gonococcal salpingitis and perihepatitis. ( 940633 )
1976
15
Gonococcal salpingitis in pregnancy. ( 984115 )
1976
16
Letter: Limitations of laparoscopy in diagnosis of gonococcal salpingitis. ( 4274055 )
1974
17
Gonococcal salpingitis. ( 4981350 )
1969

Variations for Chronic Gonococcal Salpingitis

Expression for Chronic Gonococcal Salpingitis

Search GEO for disease gene expression data for Chronic Gonococcal Salpingitis.

Pathways for Chronic Gonococcal Salpingitis

Pathways related to Chronic Gonococcal Salpingitis according to GeneCards Suite gene sharing:

(show all 31)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.74 BAK1 MCL1 TNF TNFRSF1A
2
Show member pathways
12.65 BAK1 TNF TNFRSF1A TNFRSF1B
3
Show member pathways
12.48 BLK TNF TNFRSF1A TNFRSF1B
4
Show member pathways
12.35 BAK1 TNF TNFRSF1A
5 12.33 BLK TNF TNFRSF1A TNFRSF1B
6
Show member pathways
12.28 TNF TNFRSF1A TNFRSF1B
7
Show member pathways
12.28 TNF TNFRSF1A TNFRSF1B
8
Show member pathways
12.27 TNF TNFRSF1A TNFRSF1B
9
Show member pathways
12.11 TNF TNFRSF1A TNFRSF1B
10
Show member pathways
11.87 BAK1 BLK HRK MCL1 TNF TNFRSF1A
11 11.82 BAK1 MCL1 TNF TNFRSF1A TNFRSF1B
12
Show member pathways
11.78 TNF TNFRSF1A TNFRSF1B
13 11.77 MCL1 TNF TNFRSF1B
14 11.73 TNF TNFRSF1A TNFRSF1B
15
Show member pathways
11.6 BAK1 MCL1 TNFRSF1A
16
Show member pathways
11.52 TNF TNFRSF1A TNFRSF1B
17 11.47 TNF TNFRSF1A TNFRSF1B
18 11.34 TNF TNFRSF1A TNFRSF1B
19 11.33 BLK TNF
20 11.28 TNF TNFRSF1A
21
Show member pathways
11.28 TNF TNFRSF1A TNFRSF1B
22 11.27 TNF TNFRSF1A
23 11.23 TNF TNFRSF1A TNFRSF1B
24 11.19 BAK1 MCL1
25 11.14 TNFRSF1A TNFRSF1B
26
Show member pathways
11.11 BAK1 HRK MCL1 TNFRSF1A
27 11.08 TNFRSF1A TNFRSF1B
28 11 TNF TNFRSF1A TNFRSF1B
29 10.96 BAK1 MCL1 TNF TNFRSF1A
30 10.95 TNF TNFRSF1A

GO Terms for Chronic Gonococcal Salpingitis

Cellular components related to Chronic Gonococcal Salpingitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 9.28 BAK1 BLK CLEC2A CTSA HRK MCL1
2 membrane raft GO:0045121 9.13 TNF TNFRSF1A TNFRSF1B

Biological processes related to Chronic Gonococcal Salpingitis according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 apoptotic process GO:0006915 9.72 BAK1 HRK MCL1 TNFRSF1A TNFRSF1B
2 cytokine-mediated signaling pathway GO:0019221 9.71 MCL1 TNF TNFRSF1A TNFRSF1B
3 tumor necrosis factor-mediated signaling pathway GO:0033209 9.65 TNF TNFRSF1A TNFRSF1B
4 extrinsic apoptotic signaling pathway GO:0097191 9.57 TNF TNFRSF1B
5 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.56 MCL1 TNF
6 regulation of cell proliferation GO:0042127 9.56 BLK TNF TNFRSF1A TNFRSF1B
7 extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 9.55 TNF TNFRSF1A
8 regulation of apoptotic process GO:0042981 9.55 BAK1 HRK MCL1 TNFRSF1A TNFRSF1B
9 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.54 BAK1 MCL1
10 regulation of tumor necrosis factor-mediated signaling pathway GO:0010803 9.52 TNF TNFRSF1A
11 positive regulation of release of cytochrome c from mitochondria GO:0090200 9.51 BAK1 HRK
12 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.49 TNF TNFRSF1B
13 positive regulation of ceramide biosynthetic process GO:2000304 9.46 TNF TNFRSF1A
14 death-inducing signaling complex assembly GO:0071550 9.43 TNF TNFRSF1A
15 regulation of establishment of endothelial barrier GO:1903140 9.37 TNF TNFRSF1A
16 apoptotic signaling pathway GO:0097190 9.26 BAK1 TNF TNFRSF1A TNFRSF1B
17 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.02 BAK1 MCL1 TNF TNFRSF1A TNFRSF1B

Molecular functions related to Chronic Gonococcal Salpingitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tumor necrosis factor-activated receptor activity GO:0005031 8.62 TNFRSF1A TNFRSF1B

Sources for Chronic Gonococcal Salpingitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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