MCID: CHR709
MIFTS: 20

Chronic Inducible Urticaria

Categories: Skin diseases

Aliases & Classifications for Chronic Inducible Urticaria

MalaCards integrated aliases for Chronic Inducible Urticaria:

Name: Chronic Inducible Urticaria 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0080748

Summaries for Chronic Inducible Urticaria

Disease Ontology : 12 A chronic urticaria that is characterized by a history of a consistent stimulus that initiates lesions, which are typically short-lived and fleeting, lasting a few minutes up to 2 hours.

MalaCards based summary : Chronic Inducible Urticaria is related to cholinergic urticaria and physical urticaria. An important gene associated with Chronic Inducible Urticaria is SERPINA3 (Serpin Family A Member 3), and among its related pathways/superpathways are Innate Lymphoid Cell Differentiation Pathways and Hematopoietic Stem Cell Differentiation. The drug Cholinergic Agents has been mentioned in the context of this disorder. Affiliated tissues include skin.

Related Diseases for Chronic Inducible Urticaria

Diseases related to Chronic Inducible Urticaria via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 60)
# Related Disease Score Top Affiliating Genes
1 cholinergic urticaria 30.6 SERPINA3 FCER1A ENPP3
2 physical urticaria 30.6 SERPINA3 FCER1A ENPP3
3 urticaria 30.4 IL5 IL31 FCER1A ENPP3
4 chronic spontaneous urticaria 30.4 TSLP IL31 FCER1A
5 chronic urticaria 30.0 TPO FCER1A ENPP3
6 cold urticaria 10.4
7 angioedema 10.3
8 vibratory urticaria 10.2
9 urticaria, aquagenic 10.2
10 solar urticaria 10.2
11 cutaneous solitary mastocytoma 10.2 SERPINA3 ENPP3
12 amoxicillin allergy 10.2 FCER1A ENPP3
13 indolent systemic mastocytosis 10.1 SIGLEC8 ENPP3
14 crab allergy 10.1 IL5 ENPP3
15 nut allergy 10.1 IL5 ENPP3
16 chronic frontal sinusitis 10.1 SIGLEC8 IL5
17 autoimmune disease of blood 10.1 SERPINA3 IL5
18 eosinophilic gastritis 10.1 SIGLEC8 IL5
19 middle ear disease 10.1 SERPINA3 IL5
20 drug allergy 10.1 IL5 ENPP3
21 onchocerciasis 10.1 SERPINA3 IL5
22 pollen allergy 10.0 IL5 ENPP3
23 respiratory allergy 10.0 IL5 ENPP3
24 mite infestation 10.0 IL5 IL31
25 allergic bronchopulmonary aspergillosis 10.0 IL5 ENPP3
26 chronic eosinophilic leukemia 10.0 SIGLEC8 IL5
27 commensal bacterial infectious disease 10.0 SERPINA3 IL5
28 esophagitis 10.0 TSLP IL5
29 dermatographia 10.0 ZRANB3 FCER1A ENPP3
30 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.0
31 neurodermatitis 10.0 TSLP IL31
32 trichinosis 9.9 TSLP IL5
33 irritant dermatitis 9.9 TSLP IL31
34 psoriasis 15 9.9 TSLP IL31
35 chronic conjunctivitis 9.9 TSLP IL5
36 dermatitis herpetiformis 9.9 IL5 IL31
37 eosinophilic gastroenteritis 9.9 TSLP IL5
38 gastroenteritis 9.9 TSLP IL5
39 conjunctival disease 9.9 TSLP IL5
40 food allergy 9.9 IL5 ENPP3
41 nasal cavity disease 9.8 TSLP IL5
42 parasitic protozoa infectious disease 9.8 SERPINA3 IL5
43 common cold 9.8 TSLP IL5
44 ascaris lumbricoides infection 9.8 TSLP SERPINA3 IL5
45 nose disease 9.8 TSLP SERPINA3 IL5
46 keratoconjunctivitis 9.8 TSLP IL5
47 parasitic helminthiasis infectious disease 9.8 TSLP SERPINA3 IL5
48 bronchial disease 9.8 TSLP SERPINA3 IL5
49 egg allergy 9.8 TSLP IL5 ENPP3
50 upper respiratory tract disease 9.8 TSLP SERPINA3 IL5

Graphical network of the top 20 diseases related to Chronic Inducible Urticaria:



Diseases related to Chronic Inducible Urticaria

Symptoms & Phenotypes for Chronic Inducible Urticaria

Drugs & Therapeutics for Chronic Inducible Urticaria

Drugs for Chronic Inducible Urticaria (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Cholinergic Agents Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Two-part Exploratory Study Combining a Pilot Study in Healthy Subjects and Chronic Spontaneous Urticaria Patients (Part 1) and a Randomized, Subject, Investigator and Sponsor-blinded, Placebo Controlled, Study (Part 2) to Assess the MechAniSm of acTion of ligElizumab (QGE031) in Patients With Chronic uRticaria (MASTER) Recruiting NCT04513548 Phase 1 Ligelizumab;Placebo

Search NIH Clinical Center for Chronic Inducible Urticaria

Genetic Tests for Chronic Inducible Urticaria

Anatomical Context for Chronic Inducible Urticaria

MalaCards organs/tissues related to Chronic Inducible Urticaria:

40
Skin

Publications for Chronic Inducible Urticaria

Articles related to Chronic Inducible Urticaria:

(show top 50) (show all 67)
# Title Authors PMID Year
1
Vibratory Angioedema Subgroups, Features, and Treatment: Results of a Systematic Review. 61
32961312 2021
2
The global burden of chronic urticaria for the patient and society. 61
32956489 2021
3
Prevalence of Chronic Inducible Urticaria in Elderly Patients. 61
33445423 2021
4
Chronic inducible urticaria subtypes in children: Clinical features and prognosis. 61
32741017 2021
5
Omalizumab for the treatment of chronic inducible urticaria in 80 patients. 61
32730636 2021
6
Omalizumab in chronic inducible urticaria: A real-life study of efficacy, safety, predictors of treatment outcome and time to response. 61
33522024 2021
7
Omalizumab treatment and outcomes in Chinese patients with chronic spontaneous urticaria, chronic inducible urticaria, or both. 61
33510832 2021
8
Chronic urticaria in the real-life clinical practice setting in the UK: results from the noninterventional multicentre AWARE study. 61
32246853 2020
9
Socio-economic burden and resource utilisation in Italian patients with chronic urticaria: 2-year data from the AWARE study. 61
33343800 2020
10
The usage, quality and relevance of information and communications technologies in patients with chronic urticaria: A UCARE study. 61
33204387 2020
11
Refractory chronic urticaria in adults: clinical characterization and predictors of severity. 61
33292453 2020
12
Cold urticaria - What we know and what we do not know. 61
33249577 2020
13
Efficacy of omalizumab in chronic spontaneous urticaria associated with chronic inducible urticaria. 61
32544531 2020
14
Successful treatment of delayed pressure urticaria with 300 mg of omalizumab every 14 days. 61
33103846 2020
15
Symptomatic Dermographism: A Systematic Review of Treatment Options. 61
32473421 2020
16
Chronic urticaria treatment patterns and changes in quality of life: AWARE study 2-year results. 61
32983330 2020
17
Chronic inducible urticaria: classification and prominent features of physical and non-physical types. 61
32975301 2020
18
Participation of the coagulation system and fibrinolysis as well as selected biomarkers in pathogenesis of chronic urticaria with various activity degree. 61
32994787 2020
19
Omalizumab is effective in patients with chronic spontaneous urticaria plus multiple chronic inducible urticaria. 61
32496030 2020
20
Clinical experience of a chronic urticaria referral university center. 61
31287262 2020
21
Clinical characteristics and management of chronic spontaneous urticaria in patients refractory to H1-Antihistamines in Asia, Middle-East and Africa: Results from the AWARE-AMAC study. 61
32382379 2020
22
Worsening of chronic spontaneous urticaria after intake of hot pepper. 61
32170923 2020
23
Pharmacologic Management of Chronic Urticaria in Pediatric Patients: The Gap Between Guidelines and Practice. 61
31858489 2020
24
Sensitization against skin resident fungi is associated with atopy in cholinergic urticaria patients. 61
32514333 2020
25
Cholinergic Urticaria: Clinical Presentation and Natural History in a Tropical Country. 61
32596363 2020
26
Chronic inducible urticaria: confirmation through challenge tests and response to treatment. 61
32667419 2020
27
How to Treat Patients with Chronic Spontaneous Urticaria with Omalizumab: Questions and Answers. 61
31374358 2020
28
New treatments for chronic urticaria. 61
31446134 2020
29
Diagnosis and treatment of chronic inducible urticaria. 61
31102545 2019
30
Cardiac safety of second-generation H1 -antihistamines when updosed in chronic spontaneous urticaria. 61
31519068 2019
31
Chronic urticaria phenotypes: clinical differences regarding triggers, activity, prognosis and therapeutic response. 61
31903953 2019
32
Real-life treatment of patients with cholinergic urticaria in German-speaking countries. 61
31765087 2019
33
Management problems in severe chronic inducible urticaria: Two case reports. 61
31384330 2019
34
Relevance of the Basophil High-Affinity IgE Receptor in Chronic Urticaria: Clinical Experience from a Tertiary Care Institution. 61
30685572 2019
35
Natural course and prognostic factors of chronic urticaria in Korean children: A single center experience. 61
29888927 2019
36
Diagnosis and treatment of urticaria in primary care. 61
31180381 2019
37
Omalizumab in Chronic Urticaria: An Italian Survey. 61
30396176 2019
38
Validation of the Turkish version of the Urticaria Control Test: Correlation with other tools and comparison between spontaneous and inducible chronic urticaria. 61
30937134 2019
39
Effectiveness of omalizumab in chronic spontaneous urticaria assessed with patient-reported outcomes: a prospective study. 61
29729103 2018
40
Solar urticaria in 145 patients: Assessment of action spectra and impact on quality of life in adults and children. 61
29533487 2018
41
How to Approach Chronic Inducible Urticaria. 61
30033913 2018
42
Localized salt-dependent aquagenic urticaria, a rare subtype of urticaria: a case report. 61
29384119 2018
43
Chronic inducible urticaria: A systematic review of treatment options. 61
29438771 2018
44
Development and validation of the Cholinergic Urticaria Quality-of-Life Questionnaire (CholU-QoL). 61
29369455 2018
45
Urticaria and Angioedema: an Update on Classification and Pathogenesis. 61
28748365 2018
46
Omalizumab treatment in patients with chronic inducible urticaria: A systematic review of published evidence. 61
28751232 2018
47
Differences in chronic spontaneous urticaria between Europe and Central/South America: results of the multi-center real world AWARE study. 61
30464782 2018
48
Long-term management of chronic spontaneous urticaria with omalizumab. 61
28649751 2017
49
Management of chronic inducible urticaria according to the guidelines: A prospective controlled study. 61
28314658 2017
50
[Chronic urticaria in childhood : Rational diagnostics and treatment]. 61
28474101 2017

Variations for Chronic Inducible Urticaria

Expression for Chronic Inducible Urticaria

Search GEO for disease gene expression data for Chronic Inducible Urticaria.

Pathways for Chronic Inducible Urticaria

Pathways related to Chronic Inducible Urticaria according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.22 TSLP IL5
2 10.94 TPO IL5
3 10.86 SIGLEC8 IL5 FCER1A
4 10.82 IL5 IL31
5 10.46 TSLP IL5

GO Terms for Chronic Inducible Urticaria

Cellular components related to Chronic Inducible Urticaria according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.02 TSLP TPO SERPINA3 IL5 IL31

Molecular functions related to Chronic Inducible Urticaria according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.8 TSLP IL5 IL31

Sources for Chronic Inducible Urticaria

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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