MCID: CHR088
MIFTS: 26

Chronic Inflammation of Lacrimal Passage

Categories: Eye diseases, Neuronal diseases

Aliases & Classifications for Chronic Inflammation of Lacrimal Passage

MalaCards integrated aliases for Chronic Inflammation of Lacrimal Passage:

Name: Chronic Inflammation of Lacrimal Passage 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:9935
ICD9CM 34 375.4
SNOMED-CT 67 193990009
ICD10 32 H04.4
UMLS 70 C0155239

Summaries for Chronic Inflammation of Lacrimal Passage

Disease Ontology : 12 A lacrimal apparatus disease that is characterized by longstanding inflammation of the lacrimal passage, and has symptom pain, increased or decreased tearing, and swelling between the eye and nose.

MalaCards based summary : Chronic Inflammation of Lacrimal Passage is related to laryngostenosis and congenital symblepharon, and has symptoms including pain An important gene associated with Chronic Inflammation of Lacrimal Passage is FREM2 (FRAS1 Related Extracellular Matrix 2), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Phospholipase-C Pathway. Affiliated tissues include eye, and related phenotypes are cellular and digestive/alimentary

Related Diseases for Chronic Inflammation of Lacrimal Passage

Diseases in the Acute Inflammation of Lacrimal Passage family:

Chronic Inflammation of Lacrimal Passage

Diseases related to Chronic Inflammation of Lacrimal Passage via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 152)
# Related Disease Score Top Affiliating Genes
1 laryngostenosis 10.4 FREM2 FRAS1
2 congenital symblepharon 10.4 FREM2 FRAS1
3 partial cryptophthalmia 10.4 FREM2 FRAS1
4 zygodactyly 1 10.4 FREM2 FRAS1
5 cryptophthalmos 10.4 FREM2 FRAS1
6 oculoectodermal syndrome 10.3 FREM2 FRAS1
7 cryptophthalmos, unilateral or bilateral, isolated 10.3 FREM2 FRAS1
8 clear cell acanthoma 10.3 FGFR2 FGF10
9 fgfr craniosynostosis syndromes 10.3 FGFR3 FGFR2
10 hemifacial hyperplasia 10.3 FGFR3 FGFR2
11 hobnail hemangioma 10.3 PIP PDPN
12 plagiocephaly 10.3 FGFR3 FGFR2
13 syndromic craniosynostosis 10.2 FGFR3 FGFR2
14 testicular spermatocytic seminoma 10.2 FGFR3 FGFR2
15 anus, imperforate 10.2 FREM2 FRAS1 FGF10
16 hypertelorism, microtia, facial clefting syndrome 10.2 FGFR3 FGFR2
17 renal hypodysplasia/aplasia 3 10.2 FREM2 FRAS1 FGFR3
18 luteoma 10.2 FGFR3 FGFR2
19 diaphragmatic hernia, congenital 10.2 FREM2 FRAS1 FGF10
20 vesicoureteral reflux 1 10.2 FREM2 FRAS1 FGFR2
21 achondroplasia, severe, with developmental delay and acanthosis nigricans 10.2 FGFR3 FGFR2
22 chromosomal duplication syndrome 10.2 FREM2 FRAS1 FGFR2
23 anal canal paget's disease 10.2 PIP KRT7
24 anal paget's disease 10.2 PIP KRT7
25 gastric signet ring cell adenocarcinoma 10.2 PIP KRT7
26 ceruminoma 10.2 PIP KRT7
27 malignant acrospiroma 10.2 PIP KRT7
28 oncocytic breast carcinoma 10.2 PIP KRT7
29 ceruminous adenocarcinoma 10.2 PIP KRT7
30 bartholin's gland disease 10.2 PIP KRT7
31 cutaneous mucoepidermoid carcinoma 10.2 PIP KRT7
32 bartholin's gland carcinoma 10.2 PIP KRT7
33 vulva adenocarcinoma 10.2 PIP KRT7
34 vulval paget's disease 10.2 PIP KRT7
35 eccrine adenocarcinoma 10.2 PIP KRT7
36 aplasia of lacrimal and salivary glands 10.2 FGFR2 FGF10
37 vulvar apocrine adenocarcinoma 10.2 PIP KRT7
38 apocrine adenocarcinoma 10.2 PIP KRT7
39 eyelid carcinoma 10.2 PIP KRT7
40 chronic maxillary sinusitis 10.2 PRTN3 PDPN
41 ureter transitional cell carcinoma 10.2 PDPN NCAM1
42 maxillary sinusitis 10.2 PRTN3 PDPN
43 malignant syringoma 10.1 PIP KRT7
44 anal canal adenocarcinoma 10.1 PIP KRT7
45 breast mucinous carcinoma 10.1 PIP KRT7
46 erysipeloid 10.1 PIP KRT7
47 gastric diffuse adenocarcinoma 10.1 PIP KRT7
48 clear cell hidradenoma 10.1 PIP KRT7
49 hidradenoma 10.1 PIP KRT7
50 esophageal adenoid cystic carcinoma 10.1 PDPN NCAM1

Graphical network of the top 20 diseases related to Chronic Inflammation of Lacrimal Passage:



Diseases related to Chronic Inflammation of Lacrimal Passage

Symptoms & Phenotypes for Chronic Inflammation of Lacrimal Passage

Symptoms:

12
  • pain

MGI Mouse Phenotypes related to Chronic Inflammation of Lacrimal Passage:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.22 FGF10 FGFR2 FGFR3 FRAS1 KRT7 NCAM1
2 digestive/alimentary MP:0005381 10.03 FGF10 FGFR2 FGFR3 FRAS1 NF1 PAX3
3 craniofacial MP:0005382 10 FGF10 FGFR2 FGFR3 FRAS1 FREM2 NF1
4 integument MP:0010771 9.97 FGF10 FGFR2 FGFR3 FRAS1 FREM2 NF1
5 hearing/vestibular/ear MP:0005377 9.88 FGF10 FGFR2 FGFR3 FREM2 NF1 PAX3
6 limbs/digits/tail MP:0005371 9.87 FGF10 FGFR2 FGFR3 FRAS1 FREM2 NF1
7 renal/urinary system MP:0005367 9.86 FGF10 FGFR2 FGFR3 FRAS1 FREM2 KRT7
8 respiratory system MP:0005388 9.76 FGF10 FGFR2 FGFR3 FRAS1 FREM2 NF1
9 skeleton MP:0005390 9.56 FGF10 FGFR2 FGFR3 FRAS1 FREM2 NF1
10 vision/eye MP:0005391 9.28 FGF10 FGFR2 FGFR3 FRAS1 FREM2 NCAM1

Drugs & Therapeutics for Chronic Inflammation of Lacrimal Passage

Search Clinical Trials , NIH Clinical Center for Chronic Inflammation of Lacrimal Passage

Genetic Tests for Chronic Inflammation of Lacrimal Passage

Anatomical Context for Chronic Inflammation of Lacrimal Passage

MalaCards organs/tissues related to Chronic Inflammation of Lacrimal Passage:

40
Eye

Publications for Chronic Inflammation of Lacrimal Passage

Variations for Chronic Inflammation of Lacrimal Passage

Expression for Chronic Inflammation of Lacrimal Passage

Search GEO for disease gene expression data for Chronic Inflammation of Lacrimal Passage.

Pathways for Chronic Inflammation of Lacrimal Passage

GO Terms for Chronic Inflammation of Lacrimal Passage

Cellular components related to Chronic Inflammation of Lacrimal Passage according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 collagen-containing extracellular matrix GO:0062023 9.02 PRTN3 NCAM1 FRAS1 FGFR2 FGF10

Biological processes related to Chronic Inflammation of Lacrimal Passage according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 animal organ morphogenesis GO:0009887 9.8 PAX3 FGFR2 FGF10
2 positive regulation of MAPK cascade GO:0043410 9.78 FGFR3 FGFR2 FGF10
3 wound healing GO:0042060 9.77 NF1 FGFR2 FGF10
4 lung development GO:0030324 9.76 PDPN FGFR2 FGF10
5 fibroblast growth factor receptor signaling pathway GO:0008543 9.7 FGFR3 FGFR2 FGF10
6 regulation of smoothened signaling pathway GO:0008589 9.62 FGFR2 FGF10
7 morphogenesis of an epithelium GO:0002009 9.61 FREM2 FRAS1
8 embryonic digestive tract morphogenesis GO:0048557 9.6 FGFR2 FGF10
9 branching involved in salivary gland morphogenesis GO:0060445 9.58 FGFR2 FGF10
10 limb bud formation GO:0060174 9.57 FGFR2 FGF10
11 organ growth GO:0035265 9.56 FGFR2 FGF10
12 positive regulation of phospholipase activity GO:0010518 9.55 FGFR3 FGFR2
13 endochondral bone growth GO:0003416 9.54 FGFR3 FGFR2
14 cell communication GO:0007154 9.54 NF1 FREM2 FRAS1
15 bud elongation involved in lung branching GO:0060449 9.51 FGFR2 FGF10
16 epidermis morphogenesis GO:0048730 9.49 FGFR2 FGF10
17 lacrimal gland development GO:0032808 9.48 FGFR2 FGF10
18 otic vesicle formation GO:0030916 9.46 FGFR2 FGF10
19 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.43 FGFR2 FGF10
20 metanephros morphogenesis GO:0003338 9.4 FRAS1 FGF10
21 mesenchymal cell differentiation involved in lung development GO:0060915 9.32 FGFR2 FGF10
22 branch elongation involved in salivary gland morphogenesis GO:0060667 9.26 FGFR2 FGF10
23 mammary gland bud formation GO:0060615 9.16 FGFR2 FGF10
24 MAPK cascade GO:0000165 9.02 NF1 NCAM1 FGFR3 FGFR2 FGF10
25 fibroblast growth factor receptor signaling pathway involved in mammary gland specification GO:0060595 8.96 FGFR2 FGF10

Molecular functions related to Chronic Inflammation of Lacrimal Passage according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 fibroblast growth factor binding GO:0017134 8.96 FGFR3 FGFR2
2 fibroblast growth factor-activated receptor activity GO:0005007 8.62 FGFR3 FGFR2

Sources for Chronic Inflammation of Lacrimal Passage

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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