MCID: CHR020
MIFTS: 36

Chronic Interstitial Cystitis

Categories: Nephrological diseases, Neuronal diseases, Oral diseases, Rare diseases

Aliases & Classifications for Chronic Interstitial Cystitis

MalaCards integrated aliases for Chronic Interstitial Cystitis:

Name: Chronic Interstitial Cystitis 12 15 17 72

Classifications:



External Ids:

Disease Ontology 12 DOID:1678
ICD9CM 35 595.1
MeSH 44 D018856
SNOMED-CT 68 44497007
ICD10 33 N30.1
UMLS 72 C0600040

Summaries for Chronic Interstitial Cystitis

Disease Ontology : 12 A chronic cystitis characterized by unpleasant sensation related to the bladder and lower urinary tract in the absence of identifiable causes and has symptom pain, has symptom pressure, has symptom discomfort, has symptom dysuria, and/or has symptom urinary frequency.

MalaCards based summary : Chronic Interstitial Cystitis is related to interstitial cystitis and cystitis, and has symptoms including pain, dysuria and pressure. An important gene associated with Chronic Interstitial Cystitis is RNASE3 (Ribonuclease A Family Member 3), and among its related pathways/superpathways is Allograft rejection. The drug Lidocaine has been mentioned in the context of this disorder. Affiliated tissues include t cells, prostate and breast.

Related Diseases for Chronic Interstitial Cystitis

Diseases in the Interstitial Cystitis family:

Chronic Interstitial Cystitis

Diseases related to Chronic Interstitial Cystitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 19)
# Related Disease Score Top Affiliating Genes
1 interstitial cystitis 12.1
2 cystitis 10.7
3 systemic lupus erythematosus 10.2
4 lupus erythematosus 10.1
5 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 9.9
6 gastrointestinal ulceration, recurrent, with dysfunctional platelets 9.9
7 protein-losing enteropathy 9.9
8 diarrhea 9.9
9 glomerulonephritis 9.9
10 bladder disease 9.9
11 verrucous carcinoma 9.9
12 proliferative glomerulonephritis 9.9
13 ileus 9.9
14 paralytic ileus 9.9
15 collagen disease 9.9
16 vasculitis 9.9
17 asthma 9.5 RNASE3 CD40LG
18 vasomotor rhinitis 9.4 RNASE3 CD40LG
19 schistosomiasis 9.2 RNASE3 CD40LG

Graphical network of the top 20 diseases related to Chronic Interstitial Cystitis:



Diseases related to Chronic Interstitial Cystitis

Symptoms & Phenotypes for Chronic Interstitial Cystitis

Symptoms:

12
  • pain
  • dysuria
  • pressure
  • discomfort
  • urinary frequency

Drugs & Therapeutics for Chronic Interstitial Cystitis

Drugs for Chronic Interstitial Cystitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lidocaine Approved, Vet_approved Phase 1 137-58-6 3676

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The LEADERSHIP 301 Trial: A 12-Week, Randomized, Multi-Center, Double-Blind, Placebo-Controlled, 3-Arm, Parallel-Group, Phase 3 Trial to Evaluate the Efficacy and Safety of 2 Doses of AQX-1125 Targeting the Src Homology 2-containing Inositol-5'-Phosphatase 1 (SHIP1) Pathway in Subjects With Interstitial Cystitis/Bladder Pain Syndrome Followed by an Extension Period Active, not recruiting NCT02858453 Phase 3 AQX-1125 100 mg;AQX-1125 200 mg;Placebo
2 A Phase 1b, Multicenter, Open Label Study Evaluating Safety, Tolerability and Preliminary Efficacy of LiRIS® 400 mg in Women With Ulcerative Interstitial Cystitis Completed NCT01879683 Phase 1 LiRIS® 400 mg
3 The Efficacy of Urine Biomarker in Patient With Interstitial Cystitis/Painful Bladder Syndrome Completed NCT02331472
4 Hyperbaric Oxygen Therapy for Inflammatory Conditions of the Urinary Bladder: A Feasibility Trial Recruiting NCT03143920 Early Phase 1

Search NIH Clinical Center for Chronic Interstitial Cystitis

Genetic Tests for Chronic Interstitial Cystitis

Anatomical Context for Chronic Interstitial Cystitis

MalaCards organs/tissues related to Chronic Interstitial Cystitis:

41
T Cells, Prostate, Breast, Brain, Liver, Lung, Kidney

Publications for Chronic Interstitial Cystitis

Articles related to Chronic Interstitial Cystitis:

(show top 50) (show all 51)
# Title Authors PMID Year
1
Lupus cystitis presenting with hidronephrosis and gastrointestinal involvement. 38
28001179 2016
2
Risk of associated conditions in relatives of subjects with interstitial cystitis. 38
25349937 2015
3
Increased brain gray matter in the primary somatosensory cortex is associated with increased pain and mood disturbance in patients with interstitial cystitis/painful bladder syndrome. 38
25132239 2015
4
Lupus cystitis: An unusual presentation of systemic lupus erythematosus. 38
25249721 2014
5
Pain: Novel lidocaine delivery device for chronic interstitial cystitis. 38
22890300 2012
6
Interstitial cystitis: a rare manifestation of primary Sjögren's syndrome, successfully treated with low dose cyclosporine. 38
21258795 2012
7
Decreased viral load and symptoms of polyomavirus-associated chronic interstitial cystitis after intravesical cidofovir treatment. 38
19292661 2009
8
Interstitial cystitis and systemic lupus erythematosus in a 20-year-old woman. 38
18696074 2008
9
The destruction of the lower urinary tract by ketamine abuse: a new syndrome? 38
18680495 2008
10
Obstructive uropathy as the only manifestation of flare in a patient with systemic lupus erythematosus and anti-phospholipid syndrome. 38
18089683 2008
11
Intravesical botulinum toxin type A in chronic interstitial cystitis: results of a pilot study. 38
18080606 2007
12
Preliminary results of suburothelial injection of botulinum a toxin in the treatment of chronic interstitial cystitis. 38
16123573 2005
13
Lipofuscinosis of the urinary bladder: a complication of chronic interstitial cystitis. 38
12418480 2002
14
Interstitial cystitis and ileus in pediatric-onset systemic lupus erythematosus. 38
10955946 2000
15
Intestinal pseudo-obstruction in systemic lupus erythematosus: an uncommon but important clinical manifestation. 38
10713642 2000
16
[Comparative assessment of conservative treatment of chronic prostatitis with application of complex unit andro-gin]. 38
16856455 2000
17
Chronic interstitial cystitis and systemic lupus erythematosus in an 8-year-old girl. 38
9543374 1998
18
Molecular marker for development of interstitial cystitis in rat model: isoactin gene expression. 38
9112567 1997
19
Cystitis associated with tiaprofenic acid: a survey of British and Irish urologists. 38
9126087 1997
20
[Chronic interstitial cystitis (Hunner) associated verrucous carcinoma of the urinary bladder]. 38
9123682 1997
21
[Urethral invagination by Solovov's technic in a patient with obliteration of the posterior urethra and a small bladder as a consequence of prostatic cancer]. 38
9036612 1996
22
Obstructive uropathy due to interstitial cystitis in a patient with systemic lupus erythematosus. 38
8706364 1996
23
Systemic lupus erythematosus with obstructive uropathy. Case report and review. 38
8924234 1995
24
Chronic interstitial cystitis occurring during the shift between rheumatoid arthritis and lupus. 38
8187433 1994
25
Traditional acupuncture and electrical stimulation of the posterior tibial nerve. A trial in chronic interstitial cystitis. 38
8493470 1993
26
Chronic interstitial cystitis. Successful treatment with intravesical idocaine. 38
1462157 1992
27
Association of chronic interstitial cystitis, protein-losing enteropathy and paralytic ileus with seronegative systemic lupus erythematosus: case report and review of the literature. 38
1606774 1992
28
Nerve fibre proliferation in interstitial cystitis. 38
2107633 1990
29
Immunopathology of interstitial cystitis. 38
2685811 1989
30
[The value of hydrostatic balloon dilatation with adjuvant pentosan polysulfate medication in therapy of chronic interstitial cystitis]. 38
2478501 1989
31
The management of chronic interstitial cystitis by substitution cystoplasty. 38
2913346 1989
32
Chronic interstitial cystitis: a heterogeneous syndrome. 38
3795363 1987
33
[Autoimmune aspects of a case of chronic interstitial cystitis]. 38
3523308 1986
34
Chronic interstitial cystitis and subcutaneous heparin. 38
2865477 1985
35
Chronic interstitial cystitis. 38
2862550 1985
36
Chronic interstitial cystitis. 38
2862324 1985
37
A clinicopathological and virological study of interstitial cystitis. 38
2985831 1985
38
Conservative management of chronic interstitial cystitis: transcutaneous electrical nerve stimulation and transurethral resection. 38
3872946 1985
39
Subcutaneous heparin in the treatment of interstitial cystitis. 38
4023647 1985
40
Mycoplasma hominis and interstitial cystitis. 38
6665676 1983
41
Chronic interstitial cystitis: increased levels of eosinophil cationic protein in serum and urine and an ameliorating effect of subcutaneous heparin. 38
6612233 1983
42
Chronic interstitial cystitis as an initial major manifestation of systemic lupus erythematosus. 38
6975827 1981
43
Electrical stimulation in interstitial cystitis. 38
6965508 1980
44
Experiences with colocystoplasties, cecocystoplasties and ileocystoplasties in urologic surgery: 40 patients. 38
671623 1978
45
The surgical treatment of chronic interstitial cystitis. 38
875802 1977
46
Chronic interstitial cystitis. 38
5159574 1971
47
The management of chronic interstitial cystitis by differential sacral neurotomy. 38
5782386 1969
48
HUNNER'S ULCER (CHRONIC INTERSTITIAL CYSTITIS). A MANIFESTATION OF COLLAGEN DISEASE. 38
14346453 1965
49
The role of hyperemia in the treatment of chronic interstitial cystitis. 38
13783247 1961
50
Chronic interstitial cystitis. 38
13832744 1960

Variations for Chronic Interstitial Cystitis

Expression for Chronic Interstitial Cystitis

LifeMap Discovery
Genes differentially expressed in tissues of Chronic Interstitial Cystitis patients vs. healthy controls: 35 (show top 50) (show all 462)
# Gene Description Tissue Up/Dn Fold Change (log2) P value
1 CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39) Urinary System + 9.09 0.000
2 MUC15 mucin 15, cell surface associated Urinary System - 7.48 0.000
3 MMP3 matrix metallopeptidase 3 Urinary System + 7.26 0.000
4 CRISP3 cysteine-rich secretory protein 3 Urinary System - 7.12 0.000
5 FMO9P flavin containing monooxygenase 9 pseudogene Urinary System - 7.00 0.000
6 DHRS2 dehydrogenase/reductase (SDR family) member 2 Urinary System - 6.96 0.000
7 C10orf99 chromosome 10 open reading frame 99 Urinary System - 6.96 0.000
8 PCSK1 proprotein convertase subtilisin/kexin type 1 Urinary System + 6.87 0.000
9 CXCL8 chemokine (C-X-C motif) ligand 8 Urinary System + 6.50 0.000
10 SNX31 sorting nexin 31 Urinary System - 6.40 0.000
11 FUT9 fucosyltransferase 9 (alpha (1,3) fucosyltransferase) Urinary System - 6.36 0.000
12 UPK1A uroplakin 1A Urinary System - 6.34 0.000
13 UPK3A uroplakin 3A Urinary System - 6.32 0.000
14 VSTM2A V-set and transmembrane domain containing 2A Urinary System - 6.20 0.000
15 BTBD16 BTB (POZ) domain containing 16 Urinary System - 6.20 0.000
16 BHMT betaine--homocysteine S-methyltransferase Urinary System - 6.13 0.000
17 ELF5 E74-like factor 5 (ets domain transcription factor) Urinary System - 6.02 0.000
18 WIF1 WNT inhibitory factor 1 Urinary System - 6.00 0.000
19 CXCL13 chemokine (C-X-C motif) ligand 13 Urinary System + 5.99 0.000
20 CR2 complement component (3d/Epstein Barr virus) receptor 2 Urinary System + 5.76 0.000
21 HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) Urinary System - 5.75 0.000
22 CRISP3 cysteine-rich secretory protein 3 Urinary System - 5.74 0.001
23 MMP1 matrix metallopeptidase 1 Urinary System + 5.74 0.000
24 RBP4 retinol binding protein 4, plasma Urinary System - 5.68 0.000
25 CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) Urinary System + 5.65 0.000
26 IGL immunoglobulin lambda locus Urinary System + 5.64 0.002
27 CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39) Urinary System + 5.62 0.002
28 CHP2 calcineurin-like EF-hand protein 2 Urinary System - 5.60 0.000
29 CXCL13 chemokine (C-X-C motif) ligand 13 Urinary System + 5.60 0.001
30 UPK1B uroplakin 1B Urinary System - 5.59 0.001
31 TFPI2 tissue factor pathway inhibitor 2 Urinary System + 5.58 0.000
32 IL11 interleukin 11 Urinary System + 5.57 0.001
33 FGFR3 fibroblast growth factor receptor 3 Urinary System - 5.57 0.000
34 SOSTDC1 sclerostin domain containing 1 Urinary System - 5.55 0.000
35 FAM3B family with sequence similarity 3, member B Urinary System - 5.53 0.000
36 TMPRSS11E transmembrane protease, serine 11E Urinary System - 5.42 0.000
37 CWH43 cell wall biogenesis 43 C-terminal homolog Urinary System - 5.40 0.000
38 HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 Urinary System + 5.40 0.030
39 LTF lactotransferrin Urinary System + 5.39 0.000
40 LTF lactotransferrin Urinary System + 5.36 0.000
41 TDO2 tryptophan 2,3-dioxygenase Urinary System + 5.35 0.000
42 SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group) Urinary System - 5.30 0.000
43 GREM1 gremlin 1, DAN family BMP antagonist Urinary System + 5.30 0.000
44 IGLV3-19 immunoglobulin lambda variable 3-19 Urinary System + 5.29 0.000
45 MMP12 matrix metallopeptidase 12 Urinary System + 5.27 0.000
46 SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 Urinary System - 5.26 0.000
47 CHRDL2 chordin-like 2 Urinary System + 5.26 0.000
48 PRAC1 prostate cancer susceptibility candidate 1 Urinary System - 5.24 0.000
49 GOLT1A golgi transport 1A Urinary System - 5.22 0.000
50 IGLJ3 immunoglobulin lambda joining 3 Urinary System + 5.16 0.000
Search GEO for disease gene expression data for Chronic Interstitial Cystitis.

Pathways for Chronic Interstitial Cystitis

Pathways related to Chronic Interstitial Cystitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.36 RNASE3 CD40LG

GO Terms for Chronic Interstitial Cystitis

Cellular components related to Chronic Interstitial Cystitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 8.62 RNASE3 CD40LG

Sources for Chronic Interstitial Cystitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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