MCID: CHR020
MIFTS: 36

Chronic Interstitial Cystitis

Categories: Nephrological diseases, Rare diseases

Aliases & Classifications for Chronic Interstitial Cystitis

MalaCards integrated aliases for Chronic Interstitial Cystitis:

Name: Chronic Interstitial Cystitis 12 15 17 70

Classifications:



External Ids:

Disease Ontology 12 DOID:1678
ICD9CM 34 595.1
MeSH 44 D018856
SNOMED-CT 67 44497007
ICD10 32 N30.1
UMLS 70 C0600040

Summaries for Chronic Interstitial Cystitis

Disease Ontology : 12 A chronic cystitis characterized by unpleasant sensation related to the bladder and lower urinary tract in the absence of identifiable causes and has symptom pain, has symptom pressure, has symptom discomfort, has symptom dysuria, and/or has symptom urinary frequency.

MalaCards based summary : Chronic Interstitial Cystitis is related to interstitial cystitis and cystitis, and has symptoms including dysuria, pain and pressure. An important gene associated with Chronic Interstitial Cystitis is C8orf37 (Chromosome 8 Open Reading Frame 37). The drug Lidocaine has been mentioned in the context of this disorder. Affiliated tissues include prostate, brain and cortex.

Related Diseases for Chronic Interstitial Cystitis

Diseases in the Interstitial Cystitis family:

Chronic Interstitial Cystitis

Diseases related to Chronic Interstitial Cystitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 30)
# Related Disease Score Top Affiliating Genes
1 interstitial cystitis 11.4
2 cystitis 10.7
3 systemic lupus erythematosus 10.2
4 retinitis pigmentosa 74 10.0 FAM161A C8orf37
5 retinitis pigmentosa 55 10.0 FAM161A C8orf37
6 retinitis pigmentosa 62 10.0 FAM161A C8orf37
7 retinitis pigmentosa 51 10.0 FAM161A C8orf37
8 retinitis pigmentosa 54 10.0 FAM161A C8orf37
9 gastrointestinal ulceration, recurrent, with dysfunctional platelets 10.0
10 protein-losing enteropathy 10.0
11 glomerulonephritis 10.0
12 bladder disease 10.0
13 verrucous carcinoma 10.0
14 proliferative glomerulonephritis 10.0
15 ileus 10.0
16 paralytic ileus 10.0
17 herpes zoster 10.0
18 collagen disease 10.0
19 lupus erythematosus 10.0
20 retinitis pigmentosa 28 9.9 FAM161A C8orf37
21 retinitis pigmentosa 71 9.9 IMPG2 DHDDS C8orf37
22 cone-rod dystrophy 16 9.9 FAM161A C8orf37
23 retinitis pigmentosa 31 9.8 FSCN2 FAM161A C8orf37
24 retinitis pigmentosa 17 9.8 PRCD FSCN2
25 stargardt disease 9.7 IMPG2 FAM161A
26 retinal degeneration 9.3 PRCD FSCN2 FAM161A DHDDS
27 leber plus disease 9.2 PRCD IMPG2 FSCN2 FAM161A C8orf37
28 retinitis pigmentosa 9.0 PRCD IMPG2 FSCN2 FAM161A DHDDS C8orf37
29 fundus dystrophy 9.0 PRCD IMPG2 FSCN2 FAM161A DHDDS C8orf37
30 cone-rod dystrophy 2 9.0 PRCD IMPG2 FSCN2 FAM161A DHDDS C8orf37

Graphical network of the top 20 diseases related to Chronic Interstitial Cystitis:



Diseases related to Chronic Interstitial Cystitis

Symptoms & Phenotypes for Chronic Interstitial Cystitis

Symptoms:

12
  • dysuria
  • pain
  • pressure
  • discomfort
  • urinary frequency

Drugs & Therapeutics for Chronic Interstitial Cystitis

Drugs for Chronic Interstitial Cystitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lidocaine Approved, Vet_approved Phase 1 137-58-6 3676

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase 1b, Multicenter, Open Label Study Evaluating Safety, Tolerability and Preliminary Efficacy of LiRIS® 400 mg in Women With Ulcerative Interstitial Cystitis Completed NCT01879683 Phase 1 LiRIS® 400 mg
2 The Efficacy of Urine Biomarker in Patient With Interstitial Cystitis/Painful Bladder Syndrome Completed NCT02331472
3 Optimizing Psychosocial Treatment of Interstitial Cystitis/Bladder Pain Syndrome Recruiting NCT04275297
4 Hyperbaric Oxygen Therapy for Inflammatory Conditions of the Urinary Bladder: A Feasibility Trial Recruiting NCT03143920 Early Phase 1

Search NIH Clinical Center for Chronic Interstitial Cystitis

Genetic Tests for Chronic Interstitial Cystitis

Anatomical Context for Chronic Interstitial Cystitis

MalaCards organs/tissues related to Chronic Interstitial Cystitis:

40
Prostate, Brain, Cortex, Pituitary, Liver

Publications for Chronic Interstitial Cystitis

Articles related to Chronic Interstitial Cystitis:

(show top 50) (show all 52)
# Title Authors PMID Year
1
Association between Chronic Interstitial Cystitis and Herpes Zoster. 61
32224999 2020
2
Lupus cystitis presenting with hidronephrosis and gastrointestinal involvement. 61
28001179 2016
3
Risk of associated conditions in relatives of subjects with interstitial cystitis. 61
25349937 2015
4
Increased brain gray matter in the primary somatosensory cortex is associated with increased pain and mood disturbance in patients with interstitial cystitis/painful bladder syndrome. 61
25132239 2015
5
Lupus cystitis: An unusual presentation of systemic lupus erythematosus. 61
25249721 2014
6
Pain: Novel lidocaine delivery device for chronic interstitial cystitis. 61
22890300 2012
7
Interstitial cystitis: a rare manifestation of primary Sjögren's syndrome, successfully treated with low dose cyclosporine. 61
21258795 2012
8
Decreased viral load and symptoms of polyomavirus-associated chronic interstitial cystitis after intravesical cidofovir treatment. 61
19292661 2009
9
The destruction of the lower urinary tract by ketamine abuse: a new syndrome? 61
18680495 2008
10
Interstitial cystitis and systemic lupus erythematosus in a 20-year-old woman. 61
18696074 2008
11
Obstructive uropathy as the only manifestation of flare in a patient with systemic lupus erythematosus and anti-phospholipid syndrome. 61
18089683 2008
12
Intravesical botulinum toxin type A in chronic interstitial cystitis: results of a pilot study. 61
18080606 2007
13
Preliminary results of suburothelial injection of botulinum a toxin in the treatment of chronic interstitial cystitis. 61
16123573 2005
14
Lipofuscinosis of the urinary bladder: a complication of chronic interstitial cystitis. 61
12418480 2002
15
Interstitial cystitis and ileus in pediatric-onset systemic lupus erythematosus. 61
10955946 2000
16
Intestinal pseudo-obstruction in systemic lupus erythematosus: an uncommon but important clinical manifestation. 61
10713642 2000
17
[Comparative assessment of conservative treatment of chronic prostatitis with application of complex unit andro-gin]. 61
16856455 2000
18
Chronic interstitial cystitis and systemic lupus erythematosus in an 8-year-old girl. 61
9543374 1998
19
Molecular marker for development of interstitial cystitis in rat model: isoactin gene expression. 61
9112567 1997
20
Cystitis associated with tiaprofenic acid: a survey of British and Irish urologists. 61
9126087 1997
21
[Chronic interstitial cystitis (Hunner) associated verrucous carcinoma of the urinary bladder]. 61
9123682 1997
22
[Urethral invagination by Solovov's technic in a patient with obliteration of the posterior urethra and a small bladder as a consequence of prostatic cancer]. 61
9036612 1996
23
Obstructive uropathy due to interstitial cystitis in a patient with systemic lupus erythematosus. 61
8706364 1996
24
Systemic lupus erythematosus with obstructive uropathy. Case report and review. 61
8924234 1995
25
Chronic interstitial cystitis occurring during the shift between rheumatoid arthritis and lupus. 61
8187433 1994
26
Traditional acupuncture and electrical stimulation of the posterior tibial nerve. A trial in chronic interstitial cystitis. 61
8493470 1993
27
Chronic interstitial cystitis. Successful treatment with intravesical idocaine. 61
1462157 1992
28
Association of chronic interstitial cystitis, protein-losing enteropathy and paralytic ileus with seronegative systemic lupus erythematosus: case report and review of the literature. 61
1606774 1992
29
Nerve fibre proliferation in interstitial cystitis. 61
2107633 1990
30
Immunopathology of interstitial cystitis. 61
2685811 1989
31
[The value of hydrostatic balloon dilatation with adjuvant pentosan polysulfate medication in therapy of chronic interstitial cystitis]. 61
2478501 1989
32
The management of chronic interstitial cystitis by substitution cystoplasty. 61
2913346 1989
33
Chronic interstitial cystitis: a heterogeneous syndrome. 61
3795363 1987
34
[Autoimmune aspects of a case of chronic interstitial cystitis]. 61
3523308 1986
35
Chronic interstitial cystitis and subcutaneous heparin. 61
2865477 1985
36
Chronic interstitial cystitis. 61
2862550 1985
37
Chronic interstitial cystitis. 61
2862324 1985
38
Conservative management of chronic interstitial cystitis: transcutaneous electrical nerve stimulation and transurethral resection. 61
3872946 1985
39
A clinicopathological and virological study of interstitial cystitis. 61
2985831 1985
40
Subcutaneous heparin in the treatment of interstitial cystitis. 61
4023647 1985
41
Mycoplasma hominis and interstitial cystitis. 61
6665676 1983
42
Chronic interstitial cystitis: increased levels of eosinophil cationic protein in serum and urine and an ameliorating effect of subcutaneous heparin. 61
6612233 1983
43
Chronic interstitial cystitis as an initial major manifestation of systemic lupus erythematosus. 61
6975827 1981
44
Electrical stimulation in interstitial cystitis. 61
6965508 1980
45
Experiences with colocystoplasties, cecocystoplasties and ileocystoplasties in urologic surgery: 40 patients. 61
671623 1978
46
The surgical treatment of chronic interstitial cystitis. 61
875802 1977
47
Chronic interstitial cystitis. 61
5159574 1971
48
The management of chronic interstitial cystitis by differential sacral neurotomy. 61
5782386 1969
49
HUNNER'S ULCER (CHRONIC INTERSTITIAL CYSTITIS). A MANIFESTATION OF COLLAGEN DISEASE. 61
14346453 1965
50
The role of hyperemia in the treatment of chronic interstitial cystitis. 61
13783247 1961

Variations for Chronic Interstitial Cystitis

Expression for Chronic Interstitial Cystitis

LifeMap Discovery
Genes differentially expressed in tissues of Chronic Interstitial Cystitis patients vs. healthy controls: 35 (show top 50) (show all 462)
# Gene Description Tissue Up/Dn Fold Change (log2) P value
1 CHI3L1 chitinase 3 like 1 Urinary System + 9.09 0.000
2 MUC15 mucin 15, cell surface associated Urinary System - 7.48 0.000
3 MMP3 matrix metallopeptidase 3 Urinary System + 7.26 0.000
4 CRISP3 cysteine rich secretory protein 3 Urinary System - 7.12 0.000
5 FMO9P flavin containing dimethylaniline monoxygenase 9, pseudogene Urinary System - 7.00 0.000
6 DHRS2 dehydrogenase/reductase 2 Urinary System - 6.96 0.000
7 C10orf99 chromosome 10 open reading frame 99 Urinary System - 6.96 0.000
8 PCSK1 proprotein convertase subtilisin/kexin type 1 Urinary System + 6.87 0.000
9 CXCL8 C-X-C motif chemokine ligand 8 Urinary System + 6.50 0.000
10 SNX31 sorting nexin 31 Urinary System - 6.40 0.000
11 FUT9 fucosyltransferase 9 Urinary System - 6.36 0.000
12 UPK1A uroplakin 1A Urinary System - 6.34 0.000
13 UPK3A uroplakin 3A Urinary System - 6.32 0.000
14 VSTM2A V-set and transmembrane domain containing 2A Urinary System - 6.20 0.000
15 BTBD16 BTB domain containing 16 Urinary System - 6.20 0.000
16 BHMT betaine--homocysteine S-methyltransferase Urinary System - 6.13 0.000
17 ELF5 E74 like ETS transcription factor 5 Urinary System - 6.02 0.000
18 WIF1 WNT inhibitory factor 1 Urinary System - 6.00 0.000
19 CXCL13 C-X-C motif chemokine ligand 13 Urinary System + 5.99 0.000
20 CR2 complement C3d receptor 2 Urinary System + 5.76 0.000
21 HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 Urinary System - 5.75 0.000
22 CRISP3 cysteine rich secretory protein 3 Urinary System - 5.74 0.001
23 MMP1 matrix metallopeptidase 1 Urinary System + 5.74 0.000
24 RBP4 retinol binding protein 4 Urinary System - 5.68 0.000
25 CCL18 C-C motif chemokine ligand 18 Urinary System + 5.65 0.000
26 IGL immunoglobulin lambda locus Urinary System + 5.64 0.002
27 CHI3L1 chitinase 3 like 1 Urinary System + 5.62 0.002
28 CHP2 calcineurin like EF-hand protein 2 Urinary System - 5.60 0.000
29 CXCL13 C-X-C motif chemokine ligand 13 Urinary System + 5.60 0.001
30 UPK1B uroplakin 1B Urinary System - 5.59 0.001
31 TFPI2 tissue factor pathway inhibitor 2 Urinary System + 5.58 0.000
32 IL11 interleukin 11 Urinary System + 5.57 0.001
33 FGFR3 fibroblast growth factor receptor 3 Urinary System - 5.57 0.000
34 SOSTDC1 sclerostin domain containing 1 Urinary System - 5.55 0.000
35 FAM3B FAM3 metabolism regulating signaling molecule B Urinary System - 5.53 0.000
36 TMPRSS11E transmembrane serine protease 11E Urinary System - 5.42 0.000
37 CWH43 cell wall biogenesis 43 C-terminal homolog Urinary System - 5.40 0.000
38 HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 Urinary System + 5.40 0.030
39 LTF lactotransferrin Urinary System + 5.39 0.000
40 LTF lactotransferrin Urinary System + 5.36 0.000
41 TDO2 tryptophan 2,3-dioxygenase Urinary System + 5.35 0.000
42 SLC14A1 solute carrier family 14 member 1 (Kidd blood group) Urinary System - 5.30 0.000
43 GREM1 gremlin 1, DAN family BMP antagonist Urinary System + 5.30 0.000
44 IGLV3-19 immunoglobulin lambda variable 3-19 Urinary System + 5.29 0.000
45 MMP12 matrix metallopeptidase 12 Urinary System + 5.27 0.000
46 SULT2A1 sulfotransferase family 2A member 1 Urinary System - 5.26 0.000
47 CHRDL2 chordin like 2 Urinary System + 5.26 0.000
48 PRAC1 PRAC1 small nuclear protein Urinary System - 5.24 0.000
49 GOLT1A golgi transport 1A Urinary System - 5.22 0.000
50 IGLJ3 immunoglobulin lambda joining 3 Urinary System + 5.16 0.000
Search GEO for disease gene expression data for Chronic Interstitial Cystitis.

Pathways for Chronic Interstitial Cystitis

GO Terms for Chronic Interstitial Cystitis

Cellular components related to Chronic Interstitial Cystitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell projection GO:0042995 9.26 PRCD IMPG2 FSCN2 FAM161A
2 photoreceptor inner segment GO:0001917 8.62 FAM161A C8orf37

Biological processes related to Chronic Interstitial Cystitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 visual perception GO:0007601 8.92 PRCD IMPG2 FSCN2 FAM161A

Sources for Chronic Interstitial Cystitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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