CIF
MCID: CHR464
MIFTS: 23

Chronic Intestinal Failure (CIF)

Categories: Fetal diseases, Gastrointestinal diseases, Infectious diseases, Rare diseases

Aliases & Classifications for Chronic Intestinal Failure

MalaCards integrated aliases for Chronic Intestinal Failure:

Name: Chronic Intestinal Failure 60
Cif 60

Characteristics:

Orphanet epidemiological data:

60
chronic intestinal failure
Inheritance: Not applicable; Age of onset: All ages;

Classifications:



External Ids:

Orphanet 60 ORPHA294422

Summaries for Chronic Intestinal Failure

MalaCards based summary : Chronic Intestinal Failure, also known as cif, is related to cystic fibrosis and acute promyelocytic leukemia. An important gene associated with Chronic Intestinal Failure is REN (Renin). The drugs Denosumab and Bone Density Conservation Agents have been mentioned in the context of this disorder. Affiliated tissues include bone, liver and brain.

Related Diseases for Chronic Intestinal Failure

Diseases in the Intestinal Disease family:

Chronic Intestinal Failure

Diseases related to Chronic Intestinal Failure via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 cystic fibrosis 10.1
2 acute promyelocytic leukemia 10.1
3 leukemia 10.1
4 short bowel syndrome 9.9
5 crohn's disease 9.7
6 liver disease 9.7
7 cholelithiasis 9.7
8 ehlers-danlos syndrome 9.7

Graphical network of the top 20 diseases related to Chronic Intestinal Failure:



Diseases related to Chronic Intestinal Failure

Symptoms & Phenotypes for Chronic Intestinal Failure

Drugs & Therapeutics for Chronic Intestinal Failure

Drugs for Chronic Intestinal Failure (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Denosumab Approved Phase 4 615258-40-7
2 Bone Density Conservation Agents Phase 4
3 Omega 3 Fatty Acid Phase 4
4 Olive Phase 4
5 Soy Bean Phase 4
6
Mecasermin Approved, Investigational 68562-41-4
7 Taurolidine Approved, Investigational Not Applicable 19388-87-5
8
Taurine Approved, Nutraceutical Not Applicable 107-35-7 1123
9 Mitogens
10 Insulin, Globin Zinc
11 insulin
12 Nutrients
13 Anti-Infective Agents Not Applicable
14 Anti-Infective Agents, Local Not Applicable
15 Pharmaceutical Solutions Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Denosumab in Metabolic Bone Disease in Chronic Intestinal Failure Patients Completed NCT02853539 Phase 4 Denosumab
2 The HOME Study (HPN With OMEGA-3) Recruiting NCT03282955 Phase 4 Lipidem;Lipofundin MCT 20%
3 Effect of Parenteral Nutrition With n-3 PUFAs on Patients With Intestinal Failure Recruiting NCT03869957 Phase 4
4 A Trial of Taurine Supplementation in Parenteral Nutrition 1 Unknown status NCT00135044 Not Applicable
5 Catheter Salvage in Intestinal Failure Patients Completed NCT03222232
6 Using IGF-1 for Nutritional Monitoring Completed NCT03277014
7 The Correlation Between Nutrients and Muscle Mass Completed NCT03400046 Nutritional Product Supplementation
8 Clinical Trial With Catheter Locking TauroSept® (Taurolidine 2%) or Saline Solution 0,9% Completed NCT01826526 Not Applicable
9 A Monocenter Prospective Study to Evaluate the Efficacy of Peripherally Inserted Central Catheter to Tunnelled Central Catheter With Cuff in Home Parenteral Nutrition for Long-term Used. Terminated NCT01840033 Not Applicable

Search NIH Clinical Center for Chronic Intestinal Failure

Genetic Tests for Chronic Intestinal Failure

Anatomical Context for Chronic Intestinal Failure

MalaCards organs/tissues related to Chronic Intestinal Failure:

42
Bone, Liver, Brain, Kidney, Spleen, Monocytes, Hypothalamus

Publications for Chronic Intestinal Failure

Articles related to Chronic Intestinal Failure:

(show top 50) (show all 99)
# Title Authors Year
1
Nanobody-based binding assay for the discovery of potent inhibitors of CFTR inhibitory factor (Cif). ( 30832908 )
2019
2
Intravenous lipid emulsions and liver function in adult patients with chronic intestinal failure: Results from a randomized clinical trial. ( 29960156 )
2018
3
Nutritional Therapy in Adult Short Bowel Syndrome Patients with Chronic Intestinal Failure. ( 29413019 )
2018
4
Vascular Ehlers-Danlos Syndrome: An Unusual Cause of Chronic Intestinal Failure in a Child. ( 29927864 )
2018
5
Home Parenteral Nutrition in Adult Patients With Chronic Intestinal Failure: Catheter-Related Complications Over 4 Decades at the Main Danish Tertiary Referral Center. ( 29505150 )
2018
6
Cholelithiasis and Related Morbidity in Chronic Intestinal Failure: a Longitudinal Cohort Study from a National Specialized Centre. ( 30324401 )
2018
7
Clinical approach to the management of Intestinal Failure Associated Liver Disease (IFALD) in adults: A position paper from the Home Artificial Nutrition and Chronic Intestinal Failure Special Interest Group of ESPEN. ( 30017241 )
2018
8
Examining the pathophysiology of short bowel syndrome and glucagon-like peptide 2 analogue suitability in chronic intestinal failure: experience from a national intestinal failure unit. ( 30111847 )
2018
9
Cost analysis of chronic intestinal failure. ( 30115462 )
2018
10
Insulin-like growth factor-1 as a nutritional monitoring factor in patients with chronic intestinal failure. ( 30126709 )
2018
11
Hypogammaglobulinemic sprue manifested as chronic intestinal failure: An uncommon but effective indication for home parenteral nutrition. ( 30289397 )
2018
12
Poor Social Support and Unemployment Are Associated With Negative Affect in Home Parenteral Nutrition-Dependent Patients With Chronic Intestinal Failure. ( 30299548 )
2018
13
Outcome of kidney function in adults on long-term home parenteral nutrition for chronic intestinal failure. ( 30658227 )
2018
14
Characterisation of cellular effects of Burkholderia pseudomallei cycle inhibiting factor (Cif). ( 29848489 )
2018
15
Association of proximal elements of social disadvantage with children's language development at 2 years: an analysis of data from the Children in Focus (CiF) sample from the ALSPAC birth cohort. ( 30479068 )
2018
16
High Incidence of Proteinuria in Children with Chronic Intestinal Failure Under Long-Term Parenteral Nutrition. ( 29077646 )
2017
17
Pediatric Chronic Intestinal Failure in Italy: Report from the 2016 Survey on Behalf of Italian Society for Gastroenterology, Hepatology and Nutrition (SIGENP). ( 29113094 )
2017
18
Corrigendum to "ESPEN guidelines on chronic intestinal failure in adults" [Clin Nutr 35 (2) (2016) 247-307]. ( 28027797 )
2017
19
Clinical classification of adult patients with chronic intestinal failure due to benign disease: An international multicenter cross-sectional survey. ( 28483328 )
2017
20
Managing Successful Pregnancies in Patients with Chronic Intestinal Failure on Home Parenteral Nutrition: Experience from a UK National Intestinal Failure Unit. ( 29253052 )
2017
21
Revised ESPEN Clinical Classification of Chronic Intestinal Failure: From 16 to 8 Categories. ( 28972458 )
2017
22
Home Parenteral Nutrition in Adult Patients With Chronic Intestinal Failure: The Evolution Over 4 Decades in a Tertiary Referral Center. ( 27323776 )
2016
23
Pregnancy is possible on long-term home parenteral nutrition in patients with chronic intestinal failure: Results of a long term retrospective observational study. ( 27624996 )
2016
24
ESPEN guidelines on chronic intestinal failure in adults. ( 26944585 )
2016
25
Home Parenteral Nutrition in Adult Patients With Chronic Intestinal Failure: Catheter-Related Complications Over 4 Decades at the Main Danish Tertiary Referral Center. ( 27875289 )
2016
26
Visualizing the Mechanism of Epoxide Hydrolysis by the Bacterial Virulence Enzyme Cif. ( 26752215 )
2016
27
COD::CIF::Parser: an error-correcting CIF parser for the Perl language. ( 26937241 )
2016
28
New Innovations in Dental Licensure Examinations: Patient Centered CIF. ( 27024965 )
2016
29
A Single-Center, Adult Chronic Intestinal Failure Cohort Analyzed According to the ESPEN-Endorsed Recommendations, Definitions, and Classifications. ( 26488457 )
2015
30
"Ninjinto" (Ginseng Decoction), a Traditional Japanese Herbal Medicine, Improves Gastrointestinal Symptoms and Immune Competence in Patients with Chronic Intestinal Failure. ( 26495014 )
2015
31
Conception, Pregnancy, and Lactation Despite Chronic Intestinal Failure Requiring Home Parenteral Nutrition. ( 25788322 )
2015
32
Mechanistic insights into hydroacylation with non-chelating aldehydes†Electronic supplementary information (ESI) available: Materials and methods, reaction procedures, characterization data. CCDC 1012849. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c4sc02026jClick here for additional data file. ( 25580215 )
2015
33
Flexibility transition and guest-driven reconstruction in a ferroelastic metal-organic framework†Electronic supplementary information (ESI) available: Atomic coordinates and lattice parameter data. CCDC 1016797. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c4ce01572jClick here for additional data file. ( 25632268 )
2015
34
Chronic intestinal failure after crohn disease: when to perform transplantation. ( 25162284 )
2014
35
Signature motifs identify an Acinetobacter Cif virulence factor with epoxide hydrolase activity. ( 24474692 )
2014
36
Epoxide-mediated differential packaging of Cif and other virulence factors into outer membrane vesicles. ( 25112474 )
2014
37
Ionothermal synthesis of open-framework metal phosphates with a Kagomé lattice network exhibiting canted anti-ferromagnetism†Electronic supplementary information (ESI) available: Cif files, atomic parameters, X-ray diffraction patterns, IR spectra, TG curves, and thermal ellipsoid plot and atomic label schemes of compound 1-4. See DOI: 10.1039/c4tc00290cClick here for additional data file. ( 25580250 )
2014
38
Orthogonal halogen and hydrogen bonds involving a peptide bond model†Electronic supplementary information (ESI) available: Experimental part, DSC, IR spectroscopic and crystallographic data. CCDC 899779-899785. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c4ce01514bClick here for additional data file.Click here for additional data file. ( 25663816 )
2014
39
The cyclomodulin cycle inhibiting factor (CIF) alters cullin neddylation dynamics. ( 23589306 )
2013
40
Modular chiral gold(i) phosphite complexes†Electronic supplementary information (ESI) available: Experimental results and NMR data. CCDC 933751 (L11(AuCl)), 933752 (L12(AuCl)a), 933753 (L9(AuCl)), 933754 (L10(AuCl)), 933756 (L8(AuCl)), 933757 (L12(AuCl)e). For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c3cy00250kClick here for additional data file.Click here for additional data file. ( 25664164 )
2013
41
Intestinal and multivisceral transplantation in patients with chronic intestinal failure. ( 22456144 )
2012
42
Catheter-related complications in long-term home parenteral nutrition patients with chronic intestinal failure. ( 23258588 )
2012
43
Chronic intestinal failure in children. ( 22778793 )
2012
44
Pseudomonas aeruginosa Cif defines a distinct class of α/β epoxide hydrolases utilizing a His/Tyr ring-opening pair. ( 21933119 )
2012
45
Crohn's disease patients with chronic intestinal failure receiving long-term parenteral nutrition: a cross-national adult study. ( 21848855 )
2011
46
Long-term home parenteral nutrition in children with chronic intestinal failure: A 15-year experience at a single Italian centre. ( 20570223 )
2011
47
iotbx.cif: a comprehensive CIF toolbox. ( 22199401 )
2011
48
Purification, crystallization and preliminary X-ray diffraction analysis of Cif, a virulence factor secreted by Pseudomonas aeruginosa. ( 20057063 )
2010
49
Crystal structure of the cystic fibrosis transmembrane conductance regulator inhibitory factor Cif reveals novel active-site features of an epoxide hydrolase virulence factor. ( 20118260 )
2010
50
The cyclomodulin Cif of Photorhabdus luminescens inhibits insect cell proliferation and triggers host cell death by apoptosis. ( 20870031 )
2010

Variations for Chronic Intestinal Failure

Expression for Chronic Intestinal Failure

Search GEO for disease gene expression data for Chronic Intestinal Failure.

Pathways for Chronic Intestinal Failure

GO Terms for Chronic Intestinal Failure

Sources for Chronic Intestinal Failure

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....