CIF
MCID: CHR464
MIFTS: 23

Chronic Intestinal Failure (CIF)

Categories: Gastrointestinal diseases, Rare diseases

Aliases & Classifications for Chronic Intestinal Failure

MalaCards integrated aliases for Chronic Intestinal Failure:

Name: Chronic Intestinal Failure 59
Cif 59

Characteristics:

Orphanet epidemiological data:

59
chronic intestinal failure
Inheritance: Not applicable; Age of onset: All ages;

Classifications:



External Ids:

Orphanet 59 ORPHA294422

Summaries for Chronic Intestinal Failure

MalaCards based summary : Chronic Intestinal Failure, also known as cif, is related to intestinal pseudo-obstruction and short bowel syndrome. An important gene associated with Chronic Intestinal Failure is REN (Renin). The drugs Denosumab and Sorbitol have been mentioned in the context of this disorder. Affiliated tissues include liver, bone and small intestine.

Related Diseases for Chronic Intestinal Failure

Graphical network of the top 20 diseases related to Chronic Intestinal Failure:



Diseases related to Chronic Intestinal Failure

Symptoms & Phenotypes for Chronic Intestinal Failure

Drugs & Therapeutics for Chronic Intestinal Failure

Drugs for Chronic Intestinal Failure (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 39)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Denosumab Approved Phase 4 615258-40-7
2
Sorbitol Approved Phase 4 50-70-4 5780
3 Bone Density Conservation Agents Phase 4
4 Olive Phase 4
5 Gastrointestinal Agents Phase 4
6 Cathartics Phase 4
7 Omega 3 Fatty Acid Phase 4
8 Laxatives Phase 4
9 Taurolidine Approved, Investigational 19388-87-5
10
Glucagon Approved 16941-32-5
11
Mecasermin Approved, Investigational 68562-41-4
12
Tocopherol Approved, Investigational 1406-66-2, 54-28-4 14986
13
Taurine Approved, Nutraceutical 107-35-7 1123
14
Vitamin E Approved, Nutraceutical, Vet_approved 59-02-9 14985
15 Tocotrienol Investigational 6829-55-6
16 Nutrients
17 Anti-Infective Agents, Local
18 Pharmaceutical Solutions
19 Anti-Infective Agents
20 Hormones
21 Glucagon-Like Peptide 1
22 Incretins
23 Hormone Antagonists
24 Hormones, Hormone Substitutes, and Hormone Antagonists
25 insulin
26 Insulin, Globin Zinc
27 Mitogens
28 Fat Emulsions, Intravenous
29 Trace Elements
30 Parenteral Nutrition Solutions
31 Micronutrients
32 Antioxidants
33 Tocopherols
34 Soy Bean
35 Tocotrienols
36 Vitamins
37 Protective Agents
38 Soybean oil, phospholipid emulsion
39 Liver Extracts

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 Denosumab Counteracts Metabolic Bone Disease in Chronic Intestinal Failure Patients: A Randomized, Controlled Clinical Trial Completed NCT02853539 Phase 4 Denosumab
2 A Prospective, Randomized, Controlled, Double-blind, Crossover-Design, Mono-center, Phase IV Study Comparing the Effect of Omegaven in Combination With Clinoleic or Lipoplus or SMOFlipid in Home Parenteral Nutrition Patients Completed NCT03149653 Phase 4 ClinOleic (baseline);ClinOleic + Omegaven;Lipoplus (baseline);Lipoplus + Omegaven;SMOFlipid (baseline);SMOFlipid + Omegaven
3 A Randomized, Controlled, Double-blind, Multicenter Clinical Trial on Home Parenteral Nutrition Using an Omega-3 Fatty Acid Enriched MCT/LCT Lipid Emulsion Recruiting NCT03282955 Phase 4 Lipidem;Lipofundin MCT 20%
4 A Randomised Double Blind Controlled Crossover Trial of Intravenous Taurine Supplementation in Parenteral Nutrition as an Effective Treatment for Reducing Hepatobiliary Complications in Chronic Intestinal Failure Unknown status NCT00135044
5 Catheter-related Bloodstream Infections in Patients With Intestinal Failure Receiving Home Parenteral Support: Risks Related to a Catheter-salvage-strategy. Completed NCT03222232
6 The Correlation Between Nutritional Support Regimens and Muscle Mass in Patients With Chronic Intestinal Failure Completed NCT03400046 Nutritional Product Supplementation
7 Essential Fatty Acid Status & Immune Function in Parenteral Nutrition Patients Completed NCT01986153
8 Taurolidine 2% Catheter Locking to Prevent Catheter-related Bloodstream Infections in Patients on Home Parenteral Nutrition With a High Infection Risk and Those With a New Central Venous Access Device Completed NCT01826526
9 Plasma Determination of Glucagon-like Peptide 2 as a Predictor of Recovery in Adults With Acute Intestinal Failure Completed NCT00180648
10 Insulin-like Growth Factor-1 as a Nutritional Monitoring Factor in Patients With Chronic Intestinal Failure Completed NCT03277014
11 Study in Adults on HPN Who Have Developed PNALD Comparing Equivalent Doses of Two Lipid Emulsions: OMEGAVEN 10%®, Enriched in n-3 EFA, and a Standard Lipid Emulsion, Intralipid 20%® Not Enriched in n-3 EFA + Vitamin E Supplement Completed NCT01284049 Intralipid 20%®;OMEGAVEN 10%®
12 Searching Biomarkers of Acute Intestinal Ischemic Injuries Recruiting NCT03518099
13 A Monocenter Prospective Study to Evaluate the Efficacy of Peripherally Inserted Central Catheter to Tunnelled Central Catheter With Cuff in Home Parenteral Nutrition for Long-term Used: the PICCnut Study. Terminated NCT01840033

Search NIH Clinical Center for Chronic Intestinal Failure

Genetic Tests for Chronic Intestinal Failure

Anatomical Context for Chronic Intestinal Failure

MalaCards organs/tissues related to Chronic Intestinal Failure:

41
Liver, Bone, Small Intestine, Kidney, Breast

Publications for Chronic Intestinal Failure

Articles related to Chronic Intestinal Failure:

(show top 50) (show all 139)
# Title Authors PMID Year
1
Non-interventional, retrospective data of long-term home parenteral nutrition in patients with benign diseases: Analysis of a nurse register (SERECARE). 38
31276929 2019
2
Outcomes of Children With Chronic Intestinal Failure: Experience Over 2 Decades at a Tertiary Paediatric Hospital. 38
31169663 2019
3
[Intestinal Rehabilitation in Short Bowel Syndrome and Chronic Intestinal Failure]. 38
31350749 2019
4
Experience with teduglutide treatment for short bowel syndrome in clinical practice. 38
30145039 2019
5
The Long Road to the Development of Effective Therapies for the Short Gut Syndrome: A Personal Perspective. 38
31410752 2019
6
Direct costs of a home parenteral nutrition programme. 38
30005903 2019
7
Cost analysis of chronic intestinal failure. 38
30115462 2019
8
Insulin-like growth factor-1 as a nutritional monitoring factor in patients with chronic intestinal failure. 38
30126709 2019
9
Review article: diagnosis and management of intestinal failure-associated liver disease in adults. 38
31342540 2019
10
Systematic Review: Noninvasive Assessments of Intestinal Failure-Associated Liver Disease in the Adult Population. 38
30937931 2019
11
Low circulating concentrations of citrulline and FGF19 predict chronic cholestasis and poor survival in adult patients with chronic intestinal failure: development of a Model for End-Stage Intestinal Failure (MESIF risk score). 38
31075790 2019
12
Assessment of Intestinal Failure Associated Liver Disease according to different diagnostic criteria. 38
29778510 2019
13
Repair of Central Venous Catheter in a Single-Center Adult Home Parenteral Nutrition Cohort. 38
31155738 2019
14
Incisional hernia and enterocutaneous fistula in patients with chronic intestinal failure: prevalence and risk factors in a cohort of patients referred to a tertiary centre. 38
31218774 2019
15
Needs-based quality of life in adults dependent on home parenteral nutrition. 38
31060719 2019
16
Liver steatosis in adult patients on home parenteral nutrition. 38
31235954 2019
17
Poor Social Support and Unemployment Are Associated With Negative Affect in Home Parenteral Nutrition-Dependent Patients With Chronic Intestinal Failure. 38
30299548 2019
18
Examining the pathophysiology of short bowel syndrome and glucagon-like peptide 2 analogue suitability in chronic intestinal failure: experience from a national intestinal failure unit. 38
30111847 2019
19
Intestinal Failure-Associated Liver Disease. 38
30947877 2019
20
Outcome of kidney function in adults on long-term home parenteral nutrition for chronic intestinal failure. 38
30658227 2019
21
Emerging treatments for short bowel syndrome in adult patients. 38
30791759 2019
22
Home parenteral nutrition provision modalities for chronic intestinal failure in adult patients: An international survey. 38
30992207 2019
23
Long-Term Use of Mixed-Oil Lipid Emulsion in Soybean Oil-Intolerant Home Parenteral Nutrition Patients. 38
30861583 2019
24
Advanced liver function assessment in patients with intestinal failure on long-term parenteral nutrition. 38
30885502 2019
25
Determinants of Quality of Life in Patients With Intestinal Failure Receiving Long-Term Parenteral Nutrition Using the SF-36 Questionnaire: A German Single-Center Prospective Observational Study. 38
30864177 2019
26
Vascular Ehlers-Danlos Syndrome: An Unusual Cause of Chronic Intestinal Failure in a Child. 38
29927864 2019
27
Clinical approach to the management of Intestinal Failure Associated Liver Disease (IFALD) in adults: A position paper from the Home Artificial Nutrition and Chronic Intestinal Failure Special Interest Group of ESPEN. 38
30017241 2018
28
The chronic intestinal pseudo-obstruction subtype has prognostic significance in patients with severe gastrointestinal dysmotility related intestinal failure. 38
30290972 2018
29
Body composition predicts clinical outcome in patients with intestinal failure on long-term home parenteral nutrition. 38
30390880 2018
30
Intestinal failure in adults: Recommendations from the ESPEN expert groups. 38
30172658 2018
31
Hypogammaglobulinemic sprue manifested as chronic intestinal failure: An uncommon but effective indication for home parenteral nutrition. 38
30289397 2018
32
Intravenous lipid emulsions and liver function in adult chronic intestinal failure patients: results from a randomized clinical trial. 38
29960156 2018
33
Refeeding syndrome in the gastroenterology practice: how concerned should we be? 38
29994872 2018
34
Cholelithiasis and Related Morbidity in Chronic Intestinal Failure: a Longitudinal Cohort Study from a National Specialized Centre. 38
30324401 2018
35
Five-year survival and causes of death in patients on home parenteral nutrition for severe chronic and benign intestinal failure. 38
28701261 2018
36
What's new in short bowel syndrome? 38
29702489 2018
37
High Incidence of Proteinuria in Children With Chronic Intestinal Failure Under Long-term Parenteral Nutrition. 38
29077646 2018
38
Chronic Intestinal Pseudo-Obstruction in Systemic Sclerosis: An Uncommon Presentation. 38
30057521 2018
39
Noninvasive Quantitative Assessment of Hepatic Steatosis by Proton Magnetic Resonance Spectroscopy Among Adult Patients Receiving Home Parenteral Nutrition. 38
28629281 2018
40
Clinical classification of adult patients with chronic intestinal failure due to benign disease: An international multicenter cross-sectional survey. 38
28483328 2018
41
Gastrointestinal dysmotility: A qualitative exploration of the journey from symptom onset to diagnosis. 38
29575415 2018
42
Self-Evaluation of Quality of Life Among Patients Receiving Home Parenteral Nutrition: A Validation Study. 38
28441092 2018
43
Nutritional Therapy in Adult Short Bowel Syndrome Patients with Chronic Intestinal Failure. 38
29413019 2018
44
Multimodal Surgical Approach for Adult Patients With Chronic Intestinal Pseudo-Obstruction: Clinical and Psychosocial Long-term Outcomes. 38
29407314 2018
45
Home Parenteral Nutrition in Adult Patients With Chronic Intestinal Failure: Catheter-Related Complications Over 4 Decades at the Main Danish Tertiary Referral Center. 38
29505150 2018
46
Home Parenteral Nutrition: Vascular Access and Related Complications. 38
29023196 2017
47
Managing Successful Pregnancies in Patients with Chronic Intestinal Failure on Home Parenteral Nutrition: Experience from a UK National Intestinal Failure Unit. 38
29253052 2017
48
Pediatric Chronic Intestinal Failure in Italy: Report from the 2016 Survey on Behalf of Italian Society for Gastroenterology, Hepatology and Nutrition (SIGENP). 38
29113094 2017
49
Home Parenteral Nutrition in Adult Patients With Chronic Intestinal Failure: The Evolution Over 4 Decades in a Tertiary Referral Center. 38
27323776 2017
50
Pregnancy is possible on long-term home parenteral nutrition in patients with chronic intestinal failure: Results of a long term retrospective observational study. 38
27624996 2017

Variations for Chronic Intestinal Failure

Expression for Chronic Intestinal Failure

Search GEO for disease gene expression data for Chronic Intestinal Failure.

Pathways for Chronic Intestinal Failure

GO Terms for Chronic Intestinal Failure

Sources for Chronic Intestinal Failure

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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