CIF
MCID: CHR464
MIFTS: 24

Chronic Intestinal Failure (CIF)

Categories: Gastrointestinal diseases, Rare diseases

Aliases & Classifications for Chronic Intestinal Failure

MalaCards integrated aliases for Chronic Intestinal Failure:

Name: Chronic Intestinal Failure 58
Cif 58

Characteristics:

Orphanet epidemiological data:

58
chronic intestinal failure
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 58  
Rare gastroenterological diseases


External Ids:

Orphanet 58 ORPHA294422

Summaries for Chronic Intestinal Failure

MalaCards based summary : Chronic Intestinal Failure, also known as cif, is related to chronic kidney disease and intestinal pseudo-obstruction. An important gene associated with Chronic Intestinal Failure is IGF1 (Insulin Like Growth Factor 1), and among its related pathways/superpathways is Peptide hormone metabolism. The drugs Denosumab and Liver Extracts have been mentioned in the context of this disorder. Affiliated tissues include liver, bone and small intestine.

Related Diseases for Chronic Intestinal Failure

Diseases in the Intestinal Disease family:

Chronic Intestinal Failure Congenital Intestinal Disease Due to an Enzymatic Defect
Intestinal Disease Due to Fat Malabsorption Intestinal Disease Due to Vitamin Absorption Anomaly
Rare Intestinal Disease

Diseases related to Chronic Intestinal Failure via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 68)
# Related Disease Score Top Affiliating Genes
1 chronic kidney disease 29.5 REN IGF1
2 intestinal pseudo-obstruction 11.1
3 short bowel syndrome 10.4
4 cholestasis 10.1
5 liver disease 10.1
6 crohn's disease 10.1
7 bone disease 10.0
8 intestinal obstruction 10.0
9 glioma susceptibility 1 9.9
10 keratitis, hereditary 9.9
11 cystic fibrosis 9.9
12 acute promyelocytic leukemia 9.9
13 helix syndrome 9.9
14 thrombosis 9.9
15 malignant astrocytoma 9.9
16 large cell carcinoma 9.9
17 argyria 9.9
18 methotrexate toxicity 9.9
19 potter's syndrome 9.8 REN IGF1
20 gallbladder disease 1 9.8
21 body mass index quantitative trait locus 1 9.8
22 graft-versus-host disease 9.8
23 proteinuria, chronic benign 9.8
24 crohn's colitis 9.8
25 non-alcoholic fatty liver disease 9.8
26 cholelithiasis 9.8
27 bacterial infectious disease 9.8
28 intestinal atresia 9.8
29 cholecystolithiasis 9.8
30 nephrocalcinosis 9.8
31 ehlers-danlos syndrome 9.8
32 autoimmune hepatitis 9.8
33 severe acute respiratory syndrome 9.8
34 systemic scleroderma 9.8
35 intestinal disease 9.8
36 nephrolithiasis 9.8
37 acquired immunodeficiency syndrome 9.8
38 gastrointestinal system disease 9.8
39 apnea, obstructive sleep 9.8 REN IGF1
40 sexual disorder 9.8 REN IGF1
41 adult syndrome 9.8 REN IGF1
42 hypertensive heart disease 9.8 REN IGF1
43 adrenal gland disease 9.8 REN IGF1
44 pseudohypoparathyroidism 9.8 REN IGF1
45 persistent fetal circulation syndrome 9.8 REN IGF1
46 retinal vascular disease 9.8 REN IGF1
47 vascular disease 9.8 REN IGF1
48 endocrine organ benign neoplasm 9.8 REN IGF1
49 sleep apnea 9.8 REN IGF1
50 sleep disorder 9.8 REN IGF1

Graphical network of the top 20 diseases related to Chronic Intestinal Failure:



Diseases related to Chronic Intestinal Failure

Symptoms & Phenotypes for Chronic Intestinal Failure

Drugs & Therapeutics for Chronic Intestinal Failure

Drugs for Chronic Intestinal Failure (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Denosumab Approved Phase 4 615258-40-7
2 Liver Extracts Phase 4
3 Pharmaceutical Solutions Phase 4
4 Olive Phase 4
5 Fat Emulsions, Intravenous Phase 4
6 Parenteral Nutrition Solutions Phase 4
7
Taurine Approved, Nutraceutical 107-35-7 1123
8 Nutrients
9 Insulin, Globin Zinc
10 Mitogens
11 insulin

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Intravenous Lipid Emulsions and Liver Function in Adult Chronic Intestinal Failure Patients: New Results After 5 Years. Completed NCT04347902 Phase 4 Intravenous Lipid Emulsion
2 Denosumab Counteracts Metabolic Bone Disease in Chronic Intestinal Failure Patients: A Randomized, Controlled Clinical Trial Completed NCT02853539 Phase 4 Denosumab
3 A Randomised Double Blind Controlled Crossover Trial of Intravenous Taurine Supplementation in Parenteral Nutrition as an Effective Treatment for Reducing Hepatobiliary Complications in Chronic Intestinal Failure Unknown status NCT00135044
4 The Correlation Between Nutritional Support Regimens and Muscle Mass in Patients With Chronic Intestinal Failure Completed NCT03400046 Nutritional Product Supplementation
5 Insulin-like Growth Factor-1 as a Nutritional Monitoring Factor in Patients With Chronic Intestinal Failure Completed NCT03277014
6 Qualitative Assessment of the Needs and Knowledge of Patients With Chronic Intestinal Failure of Their Disease as Well as Those of Their Practitioners Not yet recruiting NCT04390633
7 A Monocenter Prospective Study to Evaluate the Efficacy of Peripherally Inserted Central Catheter to Tunnelled Central Catheter With Cuff in Home Parenteral Nutrition for Long-term Used: the PICCnut Study. Terminated NCT01840033

Search NIH Clinical Center for Chronic Intestinal Failure

Genetic Tests for Chronic Intestinal Failure

Anatomical Context for Chronic Intestinal Failure

MalaCards organs/tissues related to Chronic Intestinal Failure:

40
Liver, Bone, Small Intestine

Publications for Chronic Intestinal Failure

Articles related to Chronic Intestinal Failure:

(show top 50) (show all 169)
# Title Authors PMID Year
1
The prevalence of liver fibrosis according to non-invasive tools in a pediatric home parenteral nutrition cohort. 61
32636112 2021
2
Intravenous lipid emulsions and liver function in adult chronic intestinal failure patients: Results after 5 y of home parenteral nutrition. 61
33221116 2021
3
Quality of life after intestinal transplantation. 61
33595982 2021
4
The economic costs of home parenteral nutrition: Systematic review of partial and full economic evaluations. 61
32631611 2021
5
Repair of central venous access devices in intestinal failure patients is safe and cost-effective: A retrospective single centre cohort study. 61
33551216 2021
6
An International Survey of Clinicians' Experience Caring for Patients Receiving Home Parenteral Nutrition for Chronic Intestinal Failure During the COVID-19 Pandemic. 61
33241555 2021
7
Social and economic costs of home parenteral nutrition. 61
33183521 2020
8
Paediatric intestinal failure and transplantation. 61
33197983 2020
9
Short-Bowel Syndrome: Epidemiology, Hospitalization Trends, In-Hospital Mortality, and Healthcare Utilization. 61
33233017 2020
10
Oral intake and plasma citrulline predict quality of life in patients with intestinal failure. 61
32563769 2020
11
Home Parenteral Nutrition Patient-Reported Outcome Questionnaire: Sensitive to Quality of Life Differences Among Chronic and Prolonged Acute Intestinal Failure Patients. 61
33098583 2020
12
Intravenous supplementation type and volume are associated with 1-year outcome and major complications in patients with chronic intestinal failure. 61
31964752 2020
13
Moving on: How to switch young people with chronic intestinal failure from pediatric to adult care. a position statement by italian society of gastroenterology and hepatology and nutrition (SIGENP) and italian society of artificial nutrition and metabolism (SINPE). 61
32868212 2020
14
High Dose Intravenous Fish Oil Reduces Inflammation-A Retrospective Tale from Two Centers. 61
32961695 2020
15
Six-month outcomes of teduglutide treatment in adult patients with short bowel syndrome with chronic intestinal failure: A real-world French observational cohort study. 61
31932048 2020
16
Translation of Evidence Into Practice With Teduglutide in the Management of Adults With Intestinal Failure due to Short-Bowel Syndrome: A Review of Recent Literature. 61
31802516 2020
17
De Novo Development of Distal Jejunal and Duodenal Adenomas After 41 Months of Teduglutide Treatment in a Patient With Short-Bowel Syndrome: A Case Report. 61
32740933 2020
18
[Feasibility of near-infrared fluorescence imaging in assisting with the determination of the resection range of radiation intestinal injury]. 61
32810946 2020
19
Postsurgical Intestinal Rehabilitation Using Semisynthetic Glucagon-Like Peptide-2 Analogue (sGLP-2) at a Referral Center: Can Patients Achieve Parenteral Nutrition and sGLP-2 Independency? 61
32740966 2020
20
Sensitivity of differential time to positivity compared to pour plates for diagnosing catheter-related blood stream infection: An evaluation in patients with chronic intestinal failure. 61
31866130 2020
21
Reporting on outcome measures in pediatric chronic intestinal failure: A systematic review. 61
31551169 2020
22
Influence of different intravenous lipid emulsions on fatty acid status and laboratory and clinical outcomes in adult patients receiving home parenteral nutrition: A systematic review. 61
32758383 2020
23
Considerations for the management of home parenteral nutrition during the SARS-CoV-2 pandemic: A position paper from the Home Artificial Nutrition and Chronic Intestinal Failure Special Interest Group of ESPEN. 61
32487434 2020
24
Microsimulation Model to Compare Enteral and Parenteral Iron Supplementation in Children With Intestinal Failure. 61
32511770 2020
25
Etiology of and predictive factors for chronic intestinal failure requiring long term parenteral support in the last two decades: A retrospective study. 61
32359739 2020
26
Cost-effectiveness of Intestinal Transplantation Compared to Parenteral Nutrition in Adults. 61
32453254 2020
27
Advances in chronic intestinal failure management and therapies. 61
32073503 2020
28
A framework to support quality of care for patients with chronic intestinal failure requiring home parenteral nutrition. 61
31441085 2020
29
Portuguese Prevalence of Pediatric Chronic Intestinal Failure. 61
31972731 2020
30
Repair of Central Venous Catheter in a Single-Center Adult Home Parenteral Nutrition Cohort. 61
31155738 2020
31
Determinants of Quality of Life in Patients With Intestinal Failure Receiving Long-Term Parenteral Nutrition Using the SF-36 Questionnaire: A German Single-Center Prospective Observational Study. 61
30864177 2020
32
Long-Term Use of Mixed-Oil Lipid Emulsion in Soybean Oil-Intolerant Home Parenteral Nutrition Patients. 61
30861583 2020
33
Home parenteral nutrition provision modalities for chronic intestinal failure in adult patients: An international survey. 61
30992207 2020
34
Advanced liver function assessment in patients with intestinal failure on long-term parenteral nutrition. 61
30885502 2020
35
Liver steatosis in adult patients on home parenteral nutrition. 61
31235954 2020
36
The Role of a Nutrition Support Team in the Management of Intestinal Failure Patients. 61
31936271 2020
37
Recurring Asystole and Paradoxical Air Embolization in a Patient with a Patent Foramen Ovale Treated with Home Parenteral Nutrition. 61
33194850 2020
38
Home parenteral nutrition with an omega-3-fatty-acid-enriched MCT/LCT lipid emulsion in patients with chronic intestinal failure (the HOME study): study protocol for a randomized, controlled, multicenter, international clinical trial. 61
31888740 2019
39
Hepatobiliary Complications of Chronic Intestinal Failure. 61
31668182 2019
40
Practical management of home parenteral nutrition in infancy. 61
31606228 2019
41
Incisional hernia and enterocutaneous fistula in patients with chronic intestinal failure: prevalence and risk factors in a cohort of patients referred to a tertiary centre. 61
31218774 2019
42
Non-interventional, retrospective data of long-term home parenteral nutrition in patients with benign diseases: Analysis of a nurse register (SERECARE). 61
31276929 2019
43
The Long Road to the Development of Effective Therapies for the Short Gut Syndrome: A Personal Perspective. 61
31410752 2019
44
Cholelithiasis and Related Morbidity in Chronic Intestinal Failure: a Longitudinal Cohort Study from a National Specialized Centre. 61
30324401 2019
45
Outcomes of Children With Chronic Intestinal Failure: Experience Over 2 Decades at a Tertiary Paediatric Hospital. 61
31169663 2019
46
Review article: diagnosis and management of intestinal failure-associated liver disease in adults. 61
31342540 2019
47
Experience with teduglutide treatment for short bowel syndrome in clinical practice. 61
30145039 2019
48
[Intestinal Rehabilitation in Short Bowel Syndrome and Chronic Intestinal Failure]. 61
31350749 2019
49
Insulin-like growth factor-1 as a nutritional monitoring factor in patients with chronic intestinal failure. 61
30126709 2019
50
Direct costs of a home parenteral nutrition programme. 61
30005903 2019

Variations for Chronic Intestinal Failure

Expression for Chronic Intestinal Failure

Search GEO for disease gene expression data for Chronic Intestinal Failure.

Pathways for Chronic Intestinal Failure

Pathways related to Chronic Intestinal Failure according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.88 REN IGF1

GO Terms for Chronic Intestinal Failure

Molecular functions related to Chronic Intestinal Failure according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 insulin-like growth factor receptor binding GO:0005159 8.62 REN IGF1

Sources for Chronic Intestinal Failure

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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