CIF
MCID: CHR464
MIFTS: 23

Chronic Intestinal Failure (CIF)

Categories: Gastrointestinal diseases, Rare diseases

Aliases & Classifications for Chronic Intestinal Failure

MalaCards integrated aliases for Chronic Intestinal Failure:

Name: Chronic Intestinal Failure 58
Cif 58

Characteristics:

Orphanet epidemiological data:

58
chronic intestinal failure
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 58  
Rare gastroenterological diseases


External Ids:

Orphanet 58 ORPHA294422

Summaries for Chronic Intestinal Failure

MalaCards based summary : Chronic Intestinal Failure, also known as cif, is related to intestinal pseudo-obstruction and short bowel syndrome. An important gene associated with Chronic Intestinal Failure is REN (Renin). The drugs Denosumab and Sorbitol have been mentioned in the context of this disorder. Affiliated tissues include liver, bone and kidney.

Related Diseases for Chronic Intestinal Failure

Graphical network of the top 20 diseases related to Chronic Intestinal Failure:



Diseases related to Chronic Intestinal Failure

Symptoms & Phenotypes for Chronic Intestinal Failure

Drugs & Therapeutics for Chronic Intestinal Failure

Drugs for Chronic Intestinal Failure (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 45)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Denosumab Approved Phase 4 615258-40-7
2
Sorbitol Approved Phase 4 50-70-4 5780
3 Olive Phase 4
4 Cathartics Phase 4
5 Omega 3 Fatty Acid Phase 4
6 Laxatives Phase 4
7 Gastrointestinal Agents Phase 4
8 Taurolidine Approved, Investigational 19388-87-5
9
Glucagon Approved 16941-32-5
10
Mecasermin Approved, Investigational 68562-41-4
11
Tocopherol Approved, Investigational 1406-66-2, 54-28-4 14986
12
Heparin Approved, Investigational 9005-49-6 772 46507594
13
Edetic Acid Approved, Vet_approved 60-00-4, 62-33-9 6049
14
Pentetic acid Approved 67-43-6
15
Taurine Approved, Nutraceutical 107-35-7 1123
16
Vitamin E Approved, Nutraceutical, Vet_approved 59-02-9 14985
17
Calcium Approved, Nutraceutical 7440-70-2 271
18 Tocotrienol Investigational 6829-55-6
19 Nutrients
20 Anti-Infective Agents, Local
21 Anti-Infective Agents
22 Incretins
23 Hormone Antagonists
24 Hormones
25 Glucagon-Like Peptide 1
26 Mitogens
27 Insulin, Globin Zinc
28 insulin
29 Vitamins
30 Trace Elements
31 Liver Extracts
32 Micronutrients
33 Tocotrienols
34 Antioxidants
35 Tocopherols
36 Protective Agents
37 Soybean oil, phospholipid emulsion
38 Parenteral Nutrition Solutions
39 Fat Emulsions, Intravenous
40 Soy Bean
41 Pharmaceutical Solutions
42 Chelating Agents
43 Anticoagulants
44 Calcium, Dietary
45 calcium heparin

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Denosumab Counteracts Metabolic Bone Disease in Chronic Intestinal Failure Patients: A Randomized, Controlled Clinical Trial Completed NCT02853539 Phase 4 Denosumab
2 A Prospective, Randomized, Controlled, Double-blind, Crossover-Design, Mono-center, Phase IV Study Comparing the Effect of Omegaven in Combination With Clinoleic or Lipoplus or SMOFlipid in Home Parenteral Nutrition Patients Completed NCT03149653 Phase 4 ClinOleic (baseline);ClinOleic + Omegaven;Lipoplus (baseline);Lipoplus + Omegaven;SMOFlipid (baseline);SMOFlipid + Omegaven
3 A Randomized, Controlled, Double-blind, Multicenter Clinical Trial on Home Parenteral Nutrition Using an Omega-3 Fatty Acid Enriched MCT/LCT Lipid Emulsion Recruiting NCT03282955 Phase 4 Lipidem;Lipofundin MCT 20%
4 A Randomised Double Blind Controlled Crossover Trial of Intravenous Taurine Supplementation in Parenteral Nutrition as an Effective Treatment for Reducing Hepatobiliary Complications in Chronic Intestinal Failure Unknown status NCT00135044
5 Catheter-related Bloodstream Infections in Patients With Intestinal Failure Receiving Home Parenteral Support: Risks Related to a Catheter-salvage-strategy. Completed NCT03222232
6 The Correlation Between Nutritional Support Regimens and Muscle Mass in Patients With Chronic Intestinal Failure Completed NCT03400046 Nutritional Product Supplementation
7 Essential Fatty Acid Status & Immune Function in Parenteral Nutrition Patients Completed NCT01986153
8 Taurolidine 2% Catheter Locking to Prevent Catheter-related Bloodstream Infections in Patients on Home Parenteral Nutrition With a High Infection Risk and Those With a New Central Venous Access Device Completed NCT01826526
9 Plasma Determination of Glucagon-like Peptide 2 as a Predictor of Recovery in Adults With Acute Intestinal Failure Completed NCT00180648
10 Insulin-like Growth Factor-1 as a Nutritional Monitoring Factor in Patients With Chronic Intestinal Failure Completed NCT03277014
11 Study in Adults on HPN Who Have Developed PNALD Comparing Equivalent Doses of Two Lipid Emulsions: OMEGAVEN 10%®, Enriched in n-3 EFA, and a Standard Lipid Emulsion, Intralipid 20%® Not Enriched in n-3 EFA + Vitamin E Supplement Completed NCT01284049 Intralipid 20%®;OMEGAVEN 10%®
12 Searching Biomarkers of Acute Intestinal Ischemic Injuries Recruiting NCT03518099
13 The Use of Tetrasodium EDTA Catheter Lock Solution for Patients on Home Parenteral Nutrition: Ease of Use and Cost Analysis Recruiting NCT04067245
14 A Monocenter Prospective Study to Evaluate the Efficacy of Peripherally Inserted Central Catheter to Tunnelled Central Catheter With Cuff in Home Parenteral Nutrition for Long-term Used: the PICCnut Study. Terminated NCT01840033

Search NIH Clinical Center for Chronic Intestinal Failure

Genetic Tests for Chronic Intestinal Failure

Anatomical Context for Chronic Intestinal Failure

MalaCards organs/tissues related to Chronic Intestinal Failure:

40
Liver, Bone, Kidney, Small Intestine, Breast, Neutrophil

Publications for Chronic Intestinal Failure

Articles related to Chronic Intestinal Failure:

(show top 50) (show all 149)
# Title Authors PMID Year
1
Home parenteral nutrition provision modalities for chronic intestinal failure in adult patients: An international survey. 61
30992207 2020
2
Liver steatosis in adult patients on home parenteral nutrition. 61
31235954 2020
3
Advanced liver function assessment in patients with intestinal failure on long-term parenteral nutrition. 61
30885502 2020
4
The Role of a Nutrition Support Team in the Management of Intestinal Failure Patients. 61
31936271 2020
5
Portuguese Prevalence of Pediatric Chronic Intestinal Failure. 61
31972731 2020
6
Intravenous supplementation type and volume are associated with 1-year outcome and major complications in patients with chronic intestinal failure. 61
31964752 2020
7
Six-month outcomes of teduglutide treatment in adult patients with short bowel syndrome with chronic intestinal failure: A real-world French observational cohort study. 61
31932048 2019
8
Translation of Evidence Into Practice With Teduglutide in the Management of Adults With Intestinal Failure due to Short-Bowel Syndrome: A Review of Recent Literature. 61
31802516 2019
9
Hepatobiliary Complications of Chronic Intestinal Failure. 61
31668182 2019
10
Home parenteral nutrition with an omega-3-fatty-acid-enriched MCT/LCT lipid emulsion in patients with chronic intestinal failure (the HOME study): study protocol for a randomized, controlled, multicenter, international clinical trial. 61
31888740 2019
11
Sensitivity of differential time to positivity compared to pour plates for diagnosing catheter-related blood stream infection: An evaluation in patients with chronic intestinal failure. 61
31866130 2019
12
Incisional hernia and enterocutaneous fistula in patients with chronic intestinal failure: prevalence and risk factors in a cohort of patients referred to a tertiary centre. 61
31218774 2019
13
Practical management of home parenteral nutrition in infancy. 61
31606228 2019
14
The Long Road to the Development of Effective Therapies for the Short Gut Syndrome: A Personal Perspective. 61
31410752 2019
15
Cholelithiasis and Related Morbidity in Chronic Intestinal Failure: a Longitudinal Cohort Study from a National Specialized Centre. 61
30324401 2019
16
Non-interventional, retrospective data of long-term home parenteral nutrition in patients with benign diseases: Analysis of a nurse register (SERECARE). 61
31276929 2019
17
Reporting on outcome measures in pediatric chronic intestinal failure: A systematic review. 61
31551169 2019
18
Review article: diagnosis and management of intestinal failure-associated liver disease in adults. 61
31342540 2019
19
Outcomes of Children With Chronic Intestinal Failure: Experience Over 2 Decades at a Tertiary Paediatric Hospital. 61
31169663 2019
20
[Intestinal Rehabilitation in Short Bowel Syndrome and Chronic Intestinal Failure]. 61
31350749 2019
21
Experience with teduglutide treatment for short bowel syndrome in clinical practice. 61
30145039 2019
22
Cost analysis of chronic intestinal failure. 61
30115462 2019
23
Insulin-like growth factor-1 as a nutritional monitoring factor in patients with chronic intestinal failure. 61
30126709 2019
24
A framework to support quality of care for patients with chronic intestinal failure requiring home parenteral nutrition. 61
31441085 2019
25
Direct costs of a home parenteral nutrition programme. 61
30005903 2019
26
Systematic Review: Noninvasive Assessments of Intestinal Failure-Associated Liver Disease in the Adult Population. 61
30937931 2019
27
Low circulating concentrations of citrulline and FGF19 predict chronic cholestasis and poor survival in adult patients with chronic intestinal failure: development of a Model for End-Stage Intestinal Failure (MESIF risk score). 61
31075790 2019
28
Assessment of Intestinal Failure Associated Liver Disease according to different diagnostic criteria. 61
29778510 2019
29
Repair of Central Venous Catheter in a Single-Center Adult Home Parenteral Nutrition Cohort. 61
31155738 2019
30
Needs-based quality of life in adults dependent on home parenteral nutrition. 61
31060719 2019
31
Poor Social Support and Unemployment Are Associated With Negative Affect in Home Parenteral Nutrition-Dependent Patients With Chronic Intestinal Failure. 61
30299548 2019
32
Intestinal Failure-Associated Liver Disease. 61
30947877 2019
33
Examining the pathophysiology of short bowel syndrome and glucagon-like peptide 2 analogue suitability in chronic intestinal failure: experience from a national intestinal failure unit. 61
30111847 2019
34
Outcome of kidney function in adults on long-term home parenteral nutrition for chronic intestinal failure. 61
30658227 2019
35
Emerging treatments for short bowel syndrome in adult patients. 61
30791759 2019
36
Long-Term Use of Mixed-Oil Lipid Emulsion in Soybean Oil-Intolerant Home Parenteral Nutrition Patients. 61
30861583 2019
37
Determinants of Quality of Life in Patients With Intestinal Failure Receiving Long-Term Parenteral Nutrition Using the SF-36 Questionnaire: A German Single-Center Prospective Observational Study. 61
30864177 2019
38
Vascular Ehlers-Danlos Syndrome: An Unusual Cause of Chronic Intestinal Failure in a Child. 61
29927864 2019
39
Clinical approach to the management of Intestinal Failure Associated Liver Disease (IFALD) in adults: A position paper from the Home Artificial Nutrition and Chronic Intestinal Failure Special Interest Group of ESPEN. 61
30017241 2018
40
The chronic intestinal pseudo-obstruction subtype has prognostic significance in patients with severe gastrointestinal dysmotility related intestinal failure. 61
30290972 2018
41
Intestinal failure in adults: Recommendations from the ESPEN expert groups. 61
30172658 2018
42
Body composition predicts clinical outcome in patients with intestinal failure on long-term home parenteral nutrition. 61
30390880 2018
43
Intravenous lipid emulsions and liver function in adult chronic intestinal failure patients: results from a randomized clinical trial. 61
29960156 2018
44
Hypogammaglobulinemic sprue manifested as chronic intestinal failure: An uncommon but effective indication for home parenteral nutrition. 61
30289397 2018
45
Refeeding syndrome in the gastroenterology practice: how concerned should we be? 61
29994872 2018
46
Five-year survival and causes of death in patients on home parenteral nutrition for severe chronic and benign intestinal failure. 61
28701261 2018
47
What's new in short bowel syndrome? 61
29702489 2018
48
Noninvasive Quantitative Assessment of Hepatic Steatosis by Proton Magnetic Resonance Spectroscopy Among Adult Patients Receiving Home Parenteral Nutrition. 61
28629281 2018
49
High Incidence of Proteinuria in Children With Chronic Intestinal Failure Under Long-term Parenteral Nutrition. 61
29077646 2018
50
Chronic Intestinal Pseudo-Obstruction in Systemic Sclerosis: An Uncommon Presentation. 61
30057521 2018

Variations for Chronic Intestinal Failure

Expression for Chronic Intestinal Failure

Search GEO for disease gene expression data for Chronic Intestinal Failure.

Pathways for Chronic Intestinal Failure

GO Terms for Chronic Intestinal Failure

Sources for Chronic Intestinal Failure

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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