CIF
MCID: CHR464
MIFTS: 22

Chronic Intestinal Failure (CIF)

Categories: Gastrointestinal diseases, Rare diseases

Aliases & Classifications for Chronic Intestinal Failure

MalaCards integrated aliases for Chronic Intestinal Failure:

Name: Chronic Intestinal Failure 58
Cif 58

Characteristics:

Orphanet epidemiological data:

58
chronic intestinal failure
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 58  
Rare gastroenterological diseases


External Ids:

Orphanet 58 ORPHA294422

Summaries for Chronic Intestinal Failure

MalaCards based summary : Chronic Intestinal Failure, also known as cif, is related to intestinal pseudo-obstruction and short bowel syndrome. An important gene associated with Chronic Intestinal Failure is REN (Renin). The drugs Denosumab and Parenteral Nutrition Solutions have been mentioned in the context of this disorder. Affiliated tissues include liver, bone and small intestine.

Related Diseases for Chronic Intestinal Failure

Graphical network of the top 20 diseases related to Chronic Intestinal Failure:



Diseases related to Chronic Intestinal Failure

Symptoms & Phenotypes for Chronic Intestinal Failure

Drugs & Therapeutics for Chronic Intestinal Failure

Drugs for Chronic Intestinal Failure (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Denosumab Approved Phase 4 615258-40-7
2 Parenteral Nutrition Solutions Phase 4
3 Olive Phase 4
4 Fat Emulsions, Intravenous Phase 4
5 Liver Extracts Phase 4
6 Omega 3 Fatty Acid Phase 4
7 Taurolidine Approved, Investigational 19388-87-5
8
Glucagon Approved 16941-32-5
9
Tocopherol Approved, Investigational 1406-66-2, 54-28-4 14986
10
Heparin Approved, Investigational 9005-49-6 46507594 772
11
Taurine Approved, Nutraceutical 107-35-7 1123
12
Vitamin E Approved, Nutraceutical, Vet_approved 59-02-9 14985
13 Tocotrienol Investigational 6829-55-6
14 Nutrients
15 Anti-Infective Agents, Local
16 Anti-Infective Agents
17 Glucagon-Like Peptide 1
18 Insulin, Globin Zinc
19 Mitogens
20 insulin
21 Vitamins
22 Soybean oil, phospholipid emulsion
23 Soy Bean
24 Tocotrienols
25 Tocopherols
26 Pharmaceutical Solutions
27 calcium heparin

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 Denosumab Counteracts Metabolic Bone Disease in Chronic Intestinal Failure Patients: A Randomized, Controlled Clinical Trial Completed NCT02853539 Phase 4 Denosumab
2 Intravenous Lipid Emulsions and Liver Function in Adult Chronic Intestinal Failure Patients: New Results After 5 Years. Completed NCT04347902 Phase 4 Intravenous Lipid Emulsion
3 A Prospective, Randomized, Controlled, Double-blind, Crossover-Design, Mono-center, Phase IV Study Comparing the Effect of Omegaven in Combination With Clinoleic or Lipoplus or SMOFlipid in Home Parenteral Nutrition Patients Completed NCT03149653 Phase 4 ClinOleic (baseline);ClinOleic + Omegaven;Lipoplus (baseline);Lipoplus + Omegaven;SMOFlipid (baseline);SMOFlipid + Omegaven
4 A Randomized, Controlled, Double-blind, Multicenter Clinical Trial on Home Parenteral Nutrition Using an Omega-3 Fatty Acid Enriched MCT/LCT Lipid Emulsion Recruiting NCT03282955 Phase 4 Lipidem;Lipofundin MCT 20%
5 A Randomised Double Blind Controlled Crossover Trial of Intravenous Taurine Supplementation in Parenteral Nutrition as an Effective Treatment for Reducing Hepatobiliary Complications in Chronic Intestinal Failure Unknown status NCT00135044
6 Catheter-related Bloodstream Infections in Patients With Intestinal Failure Receiving Home Parenteral Support: Risks Related to a Catheter-salvage-strategy. Completed NCT03222232
7 The Correlation Between Nutritional Support Regimens and Muscle Mass in Patients With Chronic Intestinal Failure Completed NCT03400046 Nutritional Product Supplementation
8 Essential Fatty Acid Status & Immune Function in Parenteral Nutrition Patients Completed NCT01986153
9 Taurolidine 2% Catheter Locking to Prevent Catheter-related Bloodstream Infections in Patients on Home Parenteral Nutrition With a High Infection Risk and Those With a New Central Venous Access Device Completed NCT01826526
10 Plasma Determination of Glucagon-like Peptide 2 as a Predictor of Recovery in Adults With Acute Intestinal Failure Completed NCT00180648
11 Insulin-like Growth Factor-1 as a Nutritional Monitoring Factor in Patients With Chronic Intestinal Failure Completed NCT03277014
12 Study in Adults on HPN Who Have Developed PNALD Comparing Equivalent Doses of Two Lipid Emulsions: OMEGAVEN 10%®, Enriched in n-3 EFA, and a Standard Lipid Emulsion, Intralipid 20%® Not Enriched in n-3 EFA + Vitamin E Supplement Completed NCT01284049 Intralipid 20%®;OMEGAVEN 10%®
13 The Use of Tetrasodium EDTA Catheter Lock Solution for Patients on Home Parenteral Nutrition: Ease of Use and Cost Analysis Recruiting NCT04067245
14 Searching Biomarkers of Acute Intestinal Ischemic Injuries Recruiting NCT03518099
15 Qualitative Assessment of the Needs and Knowledge of Patients With Chronic Intestinal Failure of Their Disease as Well as Those of Their Practitioners Not yet recruiting NCT04390633
16 A Monocenter Prospective Study to Evaluate the Efficacy of Peripherally Inserted Central Catheter to Tunnelled Central Catheter With Cuff in Home Parenteral Nutrition for Long-term Used: the PICCnut Study. Terminated NCT01840033

Search NIH Clinical Center for Chronic Intestinal Failure

Genetic Tests for Chronic Intestinal Failure

Anatomical Context for Chronic Intestinal Failure

MalaCards organs/tissues related to Chronic Intestinal Failure:

40
Liver, Bone, Small Intestine, Kidney, Breast

Publications for Chronic Intestinal Failure

Articles related to Chronic Intestinal Failure:

(show top 50) (show all 155)
# Title Authors PMID Year
1
Etiology of and predictive factors for chronic intestinal failure requiring long term parenteral support in the last two decades: A retrospective study. 61
32359739 2020
2
A Microsimulation Model to Compare Enteral and Parenteral Iron Supplementation in Children with Intestinal Failure. 61
32511770 2020
3
Considerations for the management of home parenteral nutrition during the SARS-CoV-2 pandemic: A position paper from the Home Artificial Nutrition and Chronic Intestinal Failure Special Interest Group of ESPEN. 61
32487434 2020
4
Advances in chronic intestinal failure management and therapies. 61
32073503 2020
5
Cost-effectiveness of Intestinal Transplantation Compared to Parenteral Nutrition in Adults. 61
32453254 2020
6
Oral intake and plasma citrulline predict quality of life in patients with intestinal failure. 61
32563769 2020
7
A framework to support quality of care for patients with chronic intestinal failure requiring home parenteral nutrition. 61
31441085 2020
8
Portuguese Prevalence of Pediatric Chronic Intestinal Failure. 61
31972731 2020
9
Home parenteral nutrition provision modalities for chronic intestinal failure in adult patients: An international survey. 61
30992207 2020
10
Liver steatosis in adult patients on home parenteral nutrition. 61
31235954 2020
11
Repair of Central Venous Catheter in a Single-Center Adult Home Parenteral Nutrition Cohort. 61
31155738 2020
12
Determinants of Quality of Life in Patients With Intestinal Failure Receiving Long-Term Parenteral Nutrition Using the SF-36 Questionnaire: A German Single-Center Prospective Observational Study. 61
30864177 2020
13
Advanced liver function assessment in patients with intestinal failure on long-term parenteral nutrition. 61
30885502 2020
14
Long-Term Use of Mixed-Oil Lipid Emulsion in Soybean Oil-Intolerant Home Parenteral Nutrition Patients. 61
30861583 2020
15
Intravenous supplementation type and volume are associated with 1-year outcome and major complications in patients with chronic intestinal failure. 61
31964752 2020
16
The Role of a Nutrition Support Team in the Management of Intestinal Failure Patients. 61
31936271 2020
17
Home parenteral nutrition with an omega-3-fatty-acid-enriched MCT/LCT lipid emulsion in patients with chronic intestinal failure (the HOME study): study protocol for a randomized, controlled, multicenter, international clinical trial. 61
31888740 2019
18
Translation of Evidence Into Practice With Teduglutide in the Management of Adults With Intestinal Failure due to Short-Bowel Syndrome: A Review of Recent Literature. 61
31802516 2019
19
Six-month outcomes of teduglutide treatment in adult patients with short bowel syndrome with chronic intestinal failure: A real-world French observational cohort study. 61
31932048 2019
20
Hepatobiliary Complications of Chronic Intestinal Failure. 61
31668182 2019
21
Practical management of home parenteral nutrition in infancy. 61
31606228 2019
22
Incisional hernia and enterocutaneous fistula in patients with chronic intestinal failure: prevalence and risk factors in a cohort of patients referred to a tertiary centre. 61
31218774 2019
23
Sensitivity of differential time to positivity compared to pour plates for diagnosing catheter-related blood stream infection: An evaluation in patients with chronic intestinal failure. 61
31866130 2019
24
The Long Road to the Development of Effective Therapies for the Short Gut Syndrome: A Personal Perspective. 61
31410752 2019
25
Cholelithiasis and Related Morbidity in Chronic Intestinal Failure: a Longitudinal Cohort Study from a National Specialized Centre. 61
30324401 2019
26
Non-interventional, retrospective data of long-term home parenteral nutrition in patients with benign diseases: Analysis of a nurse register (SERECARE). 61
31276929 2019
27
Outcomes of Children With Chronic Intestinal Failure: Experience Over 2 Decades at a Tertiary Paediatric Hospital. 61
31169663 2019
28
Review article: diagnosis and management of intestinal failure-associated liver disease in adults. 61
31342540 2019
29
Reporting on outcome measures in pediatric chronic intestinal failure: A systematic review. 61
31551169 2019
30
Cost analysis of chronic intestinal failure. 61
30115462 2019
31
Insulin-like growth factor-1 as a nutritional monitoring factor in patients with chronic intestinal failure. 61
30126709 2019
32
Direct costs of a home parenteral nutrition programme. 61
30005903 2019
33
[Intestinal Rehabilitation in Short Bowel Syndrome and Chronic Intestinal Failure]. 61
31350749 2019
34
Experience with teduglutide treatment for short bowel syndrome in clinical practice. 61
30145039 2019
35
Systematic Review: Noninvasive Assessments of Intestinal Failure-Associated Liver Disease in the Adult Population. 61
30937931 2019
36
Low circulating concentrations of citrulline and FGF19 predict chronic cholestasis and poor survival in adult patients with chronic intestinal failure: development of a Model for End-Stage Intestinal Failure (MESIF risk score). 61
31075790 2019
37
Needs-based quality of life in adults dependent on home parenteral nutrition. 61
31060719 2019
38
Assessment of Intestinal Failure Associated Liver Disease according to different diagnostic criteria. 61
29778510 2019
39
Intestinal Failure-Associated Liver Disease. 61
30947877 2019
40
Examining the pathophysiology of short bowel syndrome and glucagon-like peptide 2 analogue suitability in chronic intestinal failure: experience from a national intestinal failure unit. 61
30111847 2019
41
Poor Social Support and Unemployment Are Associated With Negative Affect in Home Parenteral Nutrition-Dependent Patients With Chronic Intestinal Failure. 61
30299548 2019
42
Outcome of kidney function in adults on long-term home parenteral nutrition for chronic intestinal failure. 61
30658227 2019
43
Emerging treatments for short bowel syndrome in adult patients. 61
30791759 2019
44
Vascular Ehlers-Danlos Syndrome: An Unusual Cause of Chronic Intestinal Failure in a Child. 61
29927864 2019
45
Clinical approach to the management of Intestinal Failure Associated Liver Disease (IFALD) in adults: A position paper from the Home Artificial Nutrition and Chronic Intestinal Failure Special Interest Group of ESPEN. 61
30017241 2018
46
The chronic intestinal pseudo-obstruction subtype has prognostic significance in patients with severe gastrointestinal dysmotility related intestinal failure. 61
30290972 2018
47
Body composition predicts clinical outcome in patients with intestinal failure on long-term home parenteral nutrition. 61
30390880 2018
48
Intestinal failure in adults: Recommendations from the ESPEN expert groups. 61
30172658 2018
49
Refeeding syndrome in the gastroenterology practice: how concerned should we be? 61
29994872 2018
50
Intravenous lipid emulsions and liver function in adult chronic intestinal failure patients: results from a randomized clinical trial. 61
29960156 2018

Variations for Chronic Intestinal Failure

Expression for Chronic Intestinal Failure

Search GEO for disease gene expression data for Chronic Intestinal Failure.

Pathways for Chronic Intestinal Failure

GO Terms for Chronic Intestinal Failure

Sources for Chronic Intestinal Failure

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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