MCID: CHR067
MIFTS: 29

Chronic Intestinal Vascular Insufficiency

Categories: Gastrointestinal diseases, Cardiovascular diseases

Aliases & Classifications for Chronic Intestinal Vascular Insufficiency

MalaCards integrated aliases for Chronic Intestinal Vascular Insufficiency:

Name: Chronic Intestinal Vascular Insufficiency 12 15
Chronic Mesenteric Ischemia 12 73
Cmi - Chronic Mesenteric Ischaemia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8633
ICD9CM 35 557.1
UMLS 73 C0311262

Summaries for Chronic Intestinal Vascular Insufficiency

MalaCards based summary : Chronic Intestinal Vascular Insufficiency, also known as chronic mesenteric ischemia, is related to fungal esophagitis and bladder calculus, and has symptoms including abdominal angina An important gene associated with Chronic Intestinal Vascular Insufficiency is NCR3 (Natural Cytotoxicity Triggering Receptor 3), and among its related pathways/superpathways are Ferroptosis and Fatty acid metabolism.

Related Diseases for Chronic Intestinal Vascular Insufficiency

Diseases related to Chronic Intestinal Vascular Insufficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Related Disease Score Top Affiliating Genes
1 fungal esophagitis 10.7 ATP12A ATP4A
2 bladder calculus 10.7 ATP12A ATP4A
3 gastrointestinal neuroendocrine benign tumor 10.7 ATP12A ATP4A
4 neonatal candidiasis 10.7 ATP12A ATP4A
5 photoallergic dermatitis 10.7 ATP12A ATP4A
6 squamous papillomatosis 10.7 ATP12A ATP4A
7 acute laryngitis 10.7 ATP12A ATP4A
8 gastroduodenal crohn's disease 10.7 ATP12A ATP4A
9 gastric neuroendocrine neoplasm 10.7 ATP12A ATP4A
10 toxic megacolon 10.7 ATP12A ATP4A
11 aspiration pneumonitis 10.7 ATP12A ATP4A
12 postsurgical hypothyroidism 10.7 ATP12A ATP4A
13 gastric antral vascular ectasia 10.7 ATP12A ATP4A
14 esophageal candidiasis 10.7 ATP12A ATP4A
15 duodenitis 10.7 ATP12A ATP4A
16 rumination disorder 10.7 ATP12A ATP4A
17 bile reflux 10.7 ATP12A ATP4A
18 granulomatous gastritis 10.7 ATP12A ATP4A
19 active peptic ulcer disease 10.7 ATP12A ATP4A
20 laryngeal disease 10.7 ATP12A ATP4A
21 ischemic neuropathy 10.7 ATP12A ATP4A
22 capillary disease 10.7 ATP12A ATP4A
23 peptic esophagitis 10.7 ATP12A ATP4A
24 duodenal disease 10.6 ATP12A ATP4A
25 dyskinesia of esophagus 10.6 ATP12A ATP4A
26 hernia, hiatus 10.6 ATP12A ATP4A
27 congenital disorder of deglycosylation 10.6 ATP12A ATP4A
28 esophageal atresia/tracheoesophageal fistula 10.6 ATP12A ATP4A
29 laryngitis 10.6 ATP12A ATP4A
30 lymphocytic colitis 10.6 ATP12A ATP4A
31 clostridium difficile colitis 10.6 ATP12A ATP4A
32 lower urinary tract calculus 10.6 ATP12A ATP4A
33 aspiration pneumonia 10.6 ATP12A ATP4A
34 diarrhea 1, secretory chloride, congenital 10.6 ATP12A ATP4A
35 chronic laryngitis 10.6 ATP12A ATP4A
36 eosinophilic gastritis 10.5 ATP12A ATP4A
37 polyposis, skin pigmentation, alopecia, and fingernail changes 10.5 ATP12A ATP4A
38 esophageal varix 10.5 ATP12A ATP4A
39 esophagus adenocarcinoma 10.5 ATP12A ATP4A
40 myopathy, x-linked, with excessive autophagy 10.5 ATP12A ATP4A
41 gastric lymphoma 10.5 ATP12A ATP4A
42 functional gastric disease 10.5 ATP12A ATP4A SPAG7
43 pancreatic steatorrhea 10.4 ATP12A ATP4A
44 pneumatosis cystoides intestinalis 10.4 ATP12A ATP4A
45 superior mesenteric artery syndrome 10.4 ATP12A ATP4A
46 paine syndrome 10.3 ATP12A ATP4A
47 jejunoileitis 10.3 ALDH7A1 ATP12A ATP4A
48 esophagitis, eosinophilic, 1 10.3 ATP12A ATP4A
49 peptic ulcer perforation 10.2 ATP12A ATP4A
50 ischemia 10.2

Comorbidity relations with Chronic Intestinal Vascular Insufficiency via Phenotypic Disease Network (PDN): (show all 21)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Acute Vascular Insufficiency of Intestine
Aortic Valve Disease 1 Chronic Kidney Failure
Chronic Myocardial Ischemia Deficiency Anemia
Esophagitis Familial Atrial Fibrillation
Generalized Atherosclerosis Heart Disease
Hypertension, Essential Intermediate Coronary Syndrome
Intestinal Obstruction Iron Deficiency Anemia
Ischemic Heart Disease Mitral Valve Disease
Paralytic Ileus Peripheral Vascular Disease
Protein-Energy Malnutrition

Graphical network of the top 20 diseases related to Chronic Intestinal Vascular Insufficiency:



Diseases related to Chronic Intestinal Vascular Insufficiency

Symptoms & Phenotypes for Chronic Intestinal Vascular Insufficiency

UMLS symptoms related to Chronic Intestinal Vascular Insufficiency:


abdominal angina

Drugs & Therapeutics for Chronic Intestinal Vascular Insufficiency

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Investigation of Chronic Intestinal Ischemia Recruiting NCT02914912

Search NIH Clinical Center for Chronic Intestinal Vascular Insufficiency

Genetic Tests for Chronic Intestinal Vascular Insufficiency

Anatomical Context for Chronic Intestinal Vascular Insufficiency

Publications for Chronic Intestinal Vascular Insufficiency

Articles related to Chronic Intestinal Vascular Insufficiency:

# Title Authors Year
1
Ascending Aorta to Hepatic and Mesenteric Artery Bypassing, in Patients with Chronic Mesenteric Ischemia and Extensive Aortic Disease-A Case Report and Review of the Literature. ( 27908818 )
2016
2
Acute acalculous cholecystitis as a rare manifestation of chronic mesenteric ischemia. A case report. ( 27394394 )
2016
3
Prolonged idiopathic gastric dilatation following revascularization for chronic mesenteric ischemia. ( 24975870 )
2014
4
Median arcuate ligament syndrome: Use of fractional flow reserve in documentation of chronic mesenteric ischemia. ( 24939929 )
2014
5
Ileocolic to right iliac arterial transposition for the treatment of chronic mesenteric ischemia. ( 24436624 )
2013
6
A rare cause of chronic mesenteric ischemia from fibromuscular dysplasia: a case report. ( 21092091 )
2010
7
Three cases of chronic mesenteric ischemia presenting as abdominal pain and Helicobacter pylori-negative gastric ulcer. ( 15628740 )
2004
8
[Chronic mesenteric ischemia--a rare differential diagnosis of Crohn disease]. ( 7975787 )
1994

Variations for Chronic Intestinal Vascular Insufficiency

Expression for Chronic Intestinal Vascular Insufficiency

Search GEO for disease gene expression data for Chronic Intestinal Vascular Insufficiency.

Pathways for Chronic Intestinal Vascular Insufficiency

Pathways related to Chronic Intestinal Vascular Insufficiency according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.86 ACSL5 ACSL6
2
Show member pathways
10.76 ACSL5 ACSL6 ALDH7A1
3 10.5 ACSL5 ACSL6
4 10.07 ACSL5 ACSL6

GO Terms for Chronic Intestinal Vascular Insufficiency

Biological processes related to Chronic Intestinal Vascular Insufficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 potassium ion import GO:0010107 9.46 ATP12A ATP4A
2 mesoderm formation GO:0001707 9.43 GPI WLS
3 ATP hydrolysis coupled proton transport GO:0015991 9.4 ATP12A ATP4A
4 long-chain fatty acid metabolic process GO:0001676 9.37 ACSL5 ACSL6
5 long-chain fatty-acyl-CoA biosynthetic process GO:0035338 9.32 ACSL5 ACSL6
6 cellular sodium ion homeostasis GO:0006883 9.26 ATP12A ATP4A
7 cellular potassium ion homeostasis GO:0030007 9.16 ATP12A ATP4A
8 sodium ion export across plasma membrane GO:0036376 8.96 ATP12A ATP4A
9 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 8.62 ATP12A ATP4A

Molecular functions related to Chronic Intestinal Vascular Insufficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 long-chain fatty acid-CoA ligase activity GO:0004467 9.26 ACSL5 ACSL6
2 sodium:potassium-exchanging ATPase activity GO:0005391 9.16 ATP12A ATP4A
3 decanoate-CoA ligase activity GO:0102391 8.96 ACSL5 ACSL6
4 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP12A ATP4A

Sources for Chronic Intestinal Vascular Insufficiency

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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