MCID: CHR067
MIFTS: 35

Chronic Intestinal Vascular Insufficiency

Categories: Cardiovascular diseases, Gastrointestinal diseases

Aliases & Classifications for Chronic Intestinal Vascular Insufficiency

MalaCards integrated aliases for Chronic Intestinal Vascular Insufficiency:

Name: Chronic Intestinal Vascular Insufficiency 12 15
Chronic Mesenteric Ischemia 12 74
Cmi - Chronic Mesenteric Ischaemia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8633
ICD9CM 36 557.1
UMLS 74 C0311262

Summaries for Chronic Intestinal Vascular Insufficiency

MalaCards based summary : Chronic Intestinal Vascular Insufficiency, also known as chronic mesenteric ischemia, is related to ischemia and fungal esophagitis, and has symptoms including abdominal angina An important gene associated with Chronic Intestinal Vascular Insufficiency is SPAG7 (Sperm Associated Antigen 7), and among its related pathways/superpathways are Fatty acid metabolism and Fatty Acid Biosynthesis (WikiPathways). Affiliated tissues include testes, lymph node and small intestine, and related phenotype is digestive/alimentary.

Related Diseases for Chronic Intestinal Vascular Insufficiency

Diseases related to Chronic Intestinal Vascular Insufficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 77)
# Related Disease Score Top Affiliating Genes
1 ischemia 11.0
2 fungal esophagitis 10.4 ATP12A ATP4A
3 diclofenac allergy 10.4 ATP12A ATP4A
4 gastroduodenal crohn's disease 10.4 ATP12A ATP4A
5 neonatal candidiasis 10.4 ATP12A ATP4A
6 photoallergic dermatitis 10.4 ATP12A ATP4A
7 squamous papillomatosis 10.4 ATP12A ATP4A
8 toxic megacolon 10.4 ATP12A ATP4A
9 aspiration pneumonitis 10.4 ATP12A ATP4A
10 gastrointestinal neuroendocrine benign tumor 10.4 ATP12A ATP4A
11 gastric antral vascular ectasia 10.4 ATP12A ATP4A
12 granulomatous gastritis 10.4 ATP12A ATP4A
13 esophageal candidiasis 10.4 ATP12A ATP4A
14 gastric neuroendocrine neoplasm 10.4 ATP12A ATP4A
15 acute laryngitis 10.4 ATP12A ATP4A
16 laryngitis 10.4 ATP12A ATP4A
17 duodenitis 10.4 ATP12A ATP4A
18 rumination disorder 10.4 ATP12A ATP4A
19 active peptic ulcer disease 10.3 ATP12A ATP4A
20 congenital disorder of deglycosylation 10.3 ATP12A ATP4A
21 bladder calculus 10.3 ATP12A ATP4A
22 ischemic neuropathy 10.3 ATP12A ATP4A
23 bile reflux 10.3 ATP12A ATP4A
24 capillary disease 10.3 ATP12A ATP4A
25 peptic esophagitis 10.3 ATP12A ATP4A
26 dyskinesia of esophagus 10.3 ATP12A ATP4A
27 hernia, hiatus 10.3 ATP12A ATP4A
28 postsurgical hypothyroidism 10.3 ATP12A ATP4A
29 lymphocytic colitis 10.3 ATP12A ATP4A
30 esophageal atresia/tracheoesophageal fistula 10.3 ATP12A ATP4A
31 clostridium difficile colitis 10.3 ATP12A ATP4A
32 diarrhea 1, secretory chloride, congenital 10.3 ATP12A ATP4A
33 esophagitis, eosinophilic, 1 10.3 ATP12A ATP4A
34 microscopic colitis 10.3 ATP12A ATP4A
35 chronic laryngitis 10.3 ATP12A ATP4A
36 eosinophilic gastritis 10.3 ATP12A ATP4A
37 esophagus adenocarcinoma 10.3 ATP12A ATP4A
38 polyposis, skin pigmentation, alopecia, and fingernail changes 10.3 ATP12A ATP4A
39 pancreatic steatorrhea 10.3 ATP12A ATP4A
40 esophageal varix 10.3 ATP12A ATP4A
41 superior mesenteric artery syndrome 10.3 ATP12A ATP4A
42 gastric lymphoma 10.3 ATP12A ATP4A
43 functional gastric disease 10.3 ATP12A ATP4A SPAG7
44 lower urinary tract calculus 10.2 ATP12A ATP4A
45 myopathy, x-linked, with excessive autophagy 10.2 ATP12A ATP4A
46 aspiration pneumonia 10.2 ATP12A ATP4A
47 blind loop syndrome 10.2 ATP12A ATP4A
48 pneumatosis cystoides intestinalis 10.2 ATP12A ATP4A
49 microinvasive gastric cancer 10.2 ATP12A ATP4A
50 jejunoileitis 10.2 ALDH7A1 ATP12A ATP4A

Comorbidity relations with Chronic Intestinal Vascular Insufficiency via Phenotypic Disease Network (PDN): (show all 21)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Acute Vascular Insufficiency of Intestine
Aortic Valve Disease 1 Chronic Kidney Failure
Chronic Myocardial Ischemia Deficiency Anemia
Esophagitis Familial Atrial Fibrillation
Generalized Atherosclerosis Heart Disease
Hypertension, Essential Intermediate Coronary Syndrome
Intestinal Obstruction Iron Deficiency Anemia
Ischemic Heart Disease Mitral Valve Disease
Paralytic Ileus Peripheral Vascular Disease
Protein-Energy Malnutrition

Graphical network of the top 20 diseases related to Chronic Intestinal Vascular Insufficiency:



Diseases related to Chronic Intestinal Vascular Insufficiency

Symptoms & Phenotypes for Chronic Intestinal Vascular Insufficiency

UMLS symptoms related to Chronic Intestinal Vascular Insufficiency:


abdominal angina

MGI Mouse Phenotypes related to Chronic Intestinal Vascular Insufficiency:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.17 ATP12A ATP4A DYNLL1 MEIS2 POLB TNIP1

Drugs & Therapeutics for Chronic Intestinal Vascular Insufficiency

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Investigation of Chronic Intestinal Ischemia Recruiting NCT02914912
2 Evaluation of Covered Stents Versus Bare Metal Stents for Endovascular Treatment of Chronic Ischemia Mesenteric Disease. Recruiting NCT03586739 Not Applicable

Search NIH Clinical Center for Chronic Intestinal Vascular Insufficiency

Genetic Tests for Chronic Intestinal Vascular Insufficiency

Anatomical Context for Chronic Intestinal Vascular Insufficiency

MalaCards organs/tissues related to Chronic Intestinal Vascular Insufficiency:

42
Testes, Lymph Node, Small Intestine

Publications for Chronic Intestinal Vascular Insufficiency

Articles related to Chronic Intestinal Vascular Insufficiency:

(show top 50) (show all 195)
# Title Authors Year
1
Thirty-day readmission after endovascular or surgical revascularization for chronic mesenteric ischemia: Insights from the Nationwide Readmissions Database. ( 30739588 )
2019
2
Patients with chronic mesenteric ischemia have an altered sublingual microcirculation. ( 30425547 )
2018
3
Exertional Abdominal Pain as a Rare Presenting Manifestation of Chronic Mesenteric Ischemia from a Single Mesenteric Vessel Stenosis. ( 29758324 )
2018
4
"Mesenteric Steal" Physiology as a Cause of Claudication and Chronic Mesenteric Ischemia. ( 29777839 )
2018
5
Superior mesenteric artery stenting using embolic protection device for treatment of acute or chronic mesenteric ischemia. ( 29685508 )
2018
6
Spontaneous Isolated Inferior Mesenteric Artery Dissection With Chronic Mesenteric Ischemia: Case Report and Endovascular Management. ( 29716480 )
2018
7
A systematic review and meta-analysis of endovascular versus open surgical revascularization for chronic mesenteric ischemia. ( 29571626 )
2018
8
Quality Improvement Guidelines for Mesenteric Angioplasty and Stent Placement for the Treatment of Chronic Mesenteric Ischemia. ( 29574024 )
2018
9
Persistent symptom relief after revascularization in patients with single-artery chronic mesenteric ischemia. ( 29523436 )
2018
10
Multicenter study of retrograde open mesenteric artery stenting through laparotomy for treatment of acute and chronic mesenteric ischemia. ( 29548812 )
2018
11
Improved mortality in treatment of patients with endovascular interventions for chronic mesenteric ischemia. ( 29395425 )
2018
12
Impact of Body Mass Index on Outcomes after Mesenteric Revascularization for Chronic Mesenteric Ischemia. ( 29217441 )
2018
13
Bifurcated Stent Technique: A Viable Option for Treatment of Patients With Unusual Anatomy Presenting With Combined Chronic Mesenteric Ischemia and Diffuse Ischemic Gastric Ulcers. ( 29121843 )
2018
14
Chronic mesenteric ischemia: when and how to intervene on patients with celiac/SMA stenosis. ( 27998048 )
2017
15
Endovascular treatment of occluded and stenotic visceral vessels in patients with chronic mesenteric ischemia. ( 26438613 )
2017
16
Celiac and Superior/Inferior Mesenteric Angioplasty and Stenting for Chronic Mesenteric Ischemia: A Single-Center Experience. ( 27539454 )
2017
17
Endovascular Treatment of Chronic Mesenteric Ischemia in the Setting of Occlusive Superior Mesenteric Artery Lesions. ( 27581131 )
2017
18
Endovascular-First for Chronic Mesenteric Ischemia and the Importance of Long-Term Surveillance. ( 27856668 )
2017
19
Chronic mesenteric ischemia and gastric ischemia: a bad combination. ( 28283323 )
2017
20
Chronic Mesenteric Ischemia: Patient Outcomes Using Open Surgical Revascularization. ( 28301853 )
2017
21
One-year follow-up optical coherence tomography after endovascular treatment with a new-generation zotarolimus-eluting stent for chronic mesenteric ischemia. ( 28341491 )
2017
22
Symptomatic Delayed Aortic Dissection After Superior Mesenteric Artery Stenting for Chronic Mesenteric Ischemia. ( 28376703 )
2017
23
Diagnosis and treatment of chronic mesenteric ischemia: An update. ( 28395788 )
2017
24
Functional testing in the diagnosis of chronic mesenteric ischemia. ( 28395789 )
2017
25
Retrograde Aortomesenteric Bypass with Left Retrorenal Route-"French Bypass" in 16 Cases of Chronic Mesenteric Ischemia. ( 28483622 )
2017
26
Endovascular Management for Symptomatic Chronic Mesenteric Ischemia: A Single-Center Experience. ( 28764609 )
2017
27
Infrarenal aorta as the donor site for bypasses to the superior mesenteric artery for chronic mesenteric ischemia: A prospective clinical series of 24 patients. ( 28807407 )
2017
28
Comment on: Percutaneous retrograde approach for mesenteric revascularization in chronic mesenteric ischemia. ( 29089691 )
2017
29
Endovascular Versus Surgical Revascularization for Chronic Mesenteric Ischemia: Insights From the National Inpatient Sample Database. ( 29217008 )
2017
30
Endovascular-First Approach for Chronic Mesenteric Ischemia: The Critical Need for Reporting Standards and High-Grade Evidence. ( 29217009 )
2017
31
Surgical and Endovascular Management of Patients with Chronic Mesenteric Ischemia: A Single Center Experience. ( 29336771 )
2017
32
Ascending Aorta to Hepatic and Mesenteric Artery Bypassing, in Patients with Chronic Mesenteric Ischemia and Extensive Aortic Disease-A Case Report and Review of the Literature. ( 27908818 )
2016
33
Acute acalculous cholecystitis as a rare manifestation of chronic mesenteric ischemia. A case report. ( 27394394 )
2016
34
Open Mesenteric Interventions Are Equally Safe as Endovascular Interventions and Offer Better Midterm Patency for Chronic Mesenteric Ischemia. ( 26541970 )
2016
35
Chronic Mesenteric Ischemia from Diaphragmatic Compression of the Celiac and Superior Mesenteric Arteries. ( 26541971 )
2016
36
Interpretation of Abdominal CT Findings in Patients Who Develop Acute on Chronic Mesenteric Ischemia. ( 26553268 )
2016
37
Extra-Anatomic Axillo-Mesenteric Reconstruction for Chronic Mesenteric Ischemia. ( 26597240 )
2016
38
Revascularization of the superior mesenteric artery alone for treatment of chronic mesenteric ischemia. ( 26649404 )
2016
39
Chronic mesenteric ischemia outcome analysis and predictors of endovascular failure. ( 27066948 )
2016
40
Endovascular Therapy for Chronic Mesenteric Ischemia. ( 27084551 )
2016
41
Anatomic and radiologic review of chronic mesenteric ischemia and its treatment. ( 27232932 )
2016
42
Surgery for acute exacerbation of chronic mesenteric ischemia: a case report. ( 27921277 )
2016
43
Management of Loose, Frequent Stools and Fecal Incontinence in a Chronic Mesenteric Ischemia Patient with Oral Serum-derived Bovine Immunoglobulin. ( 25674029 )
2015
44
Surgical and endovascular interventions for chronic mesenteric ischemia. ( 25644829 )
2015
45
Chronic mesenteric ischemia: 20 year experience of open surgical treatment. ( 25728455 )
2015
46
Comparison of clinical outcomes of endovascular versus open revascularization for chronic mesenteric ischemia: a meta-analysis. ( 25757988 )
2015
47
Chronic mesenteric ischemia. ( 25814201 )
2015
48
Noninvasive biomagnetic detection of intestinal slow wave dysrhythmias in chronic mesenteric ischemia. ( 25930082 )
2015
49
Endovascular Versus Surgical Revascularization for the Management of Chronic Mesenteric Ischemia. ( 25964291 )
2015
50
Successful endovascular treatment of severe chronic mesenteric ischemia by concurrent triple-vessel mesenteric artery revascularization. ( 26071295 )
2015

Variations for Chronic Intestinal Vascular Insufficiency

Expression for Chronic Intestinal Vascular Insufficiency

Search GEO for disease gene expression data for Chronic Intestinal Vascular Insufficiency.

Pathways for Chronic Intestinal Vascular Insufficiency

Pathways related to Chronic Intestinal Vascular Insufficiency according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.79 ACSL5 ACSL6 ALDH7A1
2 10.5 ACSL5 ACSL6
3 10.07 ACSL5 ACSL6

GO Terms for Chronic Intestinal Vascular Insufficiency

Biological processes related to Chronic Intestinal Vascular Insufficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mesoderm formation GO:0001707 9.43 GPI WLS
2 ATP hydrolysis coupled proton transport GO:0015991 9.4 ATP12A ATP4A
3 long-chain fatty acid metabolic process GO:0001676 9.37 ACSL5 ACSL6
4 long-chain fatty-acyl-CoA biosynthetic process GO:0035338 9.32 ACSL5 ACSL6
5 cellular sodium ion homeostasis GO:0006883 9.26 ATP12A ATP4A
6 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.16 ATP12A ATP4A
7 cellular potassium ion homeostasis GO:0030007 8.96 ATP12A ATP4A
8 sodium ion export across plasma membrane GO:0036376 8.62 ATP12A ATP4A

Molecular functions related to Chronic Intestinal Vascular Insufficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 long-chain fatty acid-CoA ligase activity GO:0004467 9.26 ACSL5 ACSL6
2 sodium:potassium-exchanging ATPase activity GO:0005391 9.16 ATP12A ATP4A
3 decanoate-CoA ligase activity GO:0102391 8.96 ACSL5 ACSL6
4 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP12A ATP4A

Sources for Chronic Intestinal Vascular Insufficiency

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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