MCID: CHR067
MIFTS: 35

Chronic Intestinal Vascular Insufficiency

Categories: Cardiovascular diseases, Gastrointestinal diseases

Aliases & Classifications for Chronic Intestinal Vascular Insufficiency

MalaCards integrated aliases for Chronic Intestinal Vascular Insufficiency:

Name: Chronic Intestinal Vascular Insufficiency 12 15
Chronic Mesenteric Ischemia 12 71
Cmi - Chronic Mesenteric Ischaemia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8633
ICD9CM 34 557.1
UMLS 71 C0311262

Summaries for Chronic Intestinal Vascular Insufficiency

MalaCards based summary : Chronic Intestinal Vascular Insufficiency, also known as chronic mesenteric ischemia, is related to gastric dilatation and median arcuate ligament syndrome, and has symptoms including abdominal angina An important gene associated with Chronic Intestinal Vascular Insufficiency is ATP12A (ATPase H+/K+ Transporting Non-Gastric Alpha2 Subunit), and among its related pathways/superpathways are Mitochondrial LC-Fatty Acid Beta-Oxidation and Ferroptosis. Affiliated tissues include testes, lymph node and small intestine.

Related Diseases for Chronic Intestinal Vascular Insufficiency

Diseases related to Chronic Intestinal Vascular Insufficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 153)
# Related Disease Score Top Affiliating Genes
1 gastric dilatation 30.4 ATP4A ATP12A
2 median arcuate ligament syndrome 30.3 NCR3 ATP4A ATP12A
3 ischemia 11.0
4 pancreatic vasoactive intestinal peptide producing tumor 10.4 ATP4A ATP12A
5 hemangioma of intra-abdominal structure 10.4 ATP4A ATP12A
6 displacement of cardia through esophageal hiatus 10.4 ATP4A ATP12A
7 gastric hemangioma 10.4 ATP4A ATP12A
8 acquired gastric outlet stenosis 10.4 ATP4A ATP12A
9 angiodysplasia of intestine 10.4 ATP4A ATP12A
10 angiodysplasia 10.4 ATP4A ATP12A
11 benzylpenicillin allergy 10.4 ATP4A ATP12A
12 granulomatous gastritis 10.4 ATP4A ATP12A
13 bacterial esophagitis 10.4 ATP4A ATP12A
14 lingual goiter 10.4 ATP4A ATP12A
15 cascade stomach 10.4 ATP4A ATP12A
16 gastrojejunal ulcer 10.4 ATP4A ATP12A
17 fungal esophagitis 10.4 ATP4A ATP12A
18 gastric gastrinoma 10.4 ATP4A ATP12A
19 fungal gastritis 10.4 ATP4A ATP12A
20 superior mesenteric artery syndrome 10.4 ATP4A ATP12A
21 cervix erosion 10.4 ATP4A ATP12A
22 pneumatosis cystoides intestinalis 10.4 ATP4A ATP12A
23 dieulafoy lesion 10.4 ATP4A ATP12A
24 esophagus sarcoma 10.4 ATP4A ATP12A
25 esophagus melanoma 10.4 ATP4A ATP12A
26 polyposis, skin pigmentation, alopecia, and fingernail changes 10.4 ATP4A ATP12A
27 necrotizing gastritis 10.4 ATP4A ATP12A
28 central nervous system origin vertigo 10.4 ATP4A ATP12A
29 chronic laryngitis 10.4 ATP4A ATP12A
30 laryngitis 10.4 ATP4A ATP12A
31 cefuroxime allergy 10.4 ATP4A ATP12A
32 gastroduodenitis 10.4 ATP4A ATP12A
33 duodenitis 10.4 ATP4A ATP12A
34 peptic ulcer perforation 10.4 ATP4A ATP12A
35 rumination disorder 10.4 ATP4A ATP12A
36 blind loop syndrome 10.4 ATP4A ATP12A
37 crab allergy 10.4 ATP4A ATP12A
38 acute laryngitis 10.4 ATP4A ATP12A
39 duodenal gastrinoma 10.4 ATP4A ATP12A
40 esophageal tuberculosis 10.4 ATP4A ATP12A
41 diclofenac allergy 10.4 ATP4A ATP12A
42 internal hemorrhoid 10.4 ATP4A ATP12A
43 hemorrhoid 10.4 ATP4A ATP12A
44 lymphocytic gastritis 10.4 ATP4A ATP12A
45 duodenal obstruction 10.4 ATP4A ATP12A
46 pancreatic gastrinoma 10.4 ATP4A ATP12A
47 functional diarrhea 10.4 ATP4A ATP12A
48 gastritis, familial giant hypertrophic 10.4 ATP4A ATP12A
49 eosinophilic gastritis 10.4 ATP4A ATP12A
50 gastric antral vascular ectasia 10.4 ATP4A ATP12A

Comorbidity relations with Chronic Intestinal Vascular Insufficiency via Phenotypic Disease Network (PDN): (show all 18)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Acute Vascular Insufficiency of Intestine
Aortic Valve Disease 1 Deficiency Anemia
Esophagitis Familial Atrial Fibrillation
Generalized Atherosclerosis Heart Disease
Hypertension, Essential Intermediate Coronary Syndrome
Intestinal Obstruction Iron Deficiency Anemia
Mitral Valve Disease Paralytic Ileus
Peripheral Vascular Disease Protein-Energy Malnutrition

Graphical network of the top 20 diseases related to Chronic Intestinal Vascular Insufficiency:



Diseases related to Chronic Intestinal Vascular Insufficiency

Symptoms & Phenotypes for Chronic Intestinal Vascular Insufficiency

UMLS symptoms related to Chronic Intestinal Vascular Insufficiency:


abdominal angina

Drugs & Therapeutics for Chronic Intestinal Vascular Insufficiency

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Investigation of Chronic Intestinal Ischemia Recruiting NCT02914912
2 Evaluation of Covered Stents Versus Bare Metal Stents for Endovascular Treatment of Chronic Atherosclerotic Mesenteric Arterial Disease:a Randomised Study. Recruiting NCT03586739

Search NIH Clinical Center for Chronic Intestinal Vascular Insufficiency

Genetic Tests for Chronic Intestinal Vascular Insufficiency

Anatomical Context for Chronic Intestinal Vascular Insufficiency

MalaCards organs/tissues related to Chronic Intestinal Vascular Insufficiency:

40
Testes, Lymph Node, Small Intestine, Colon, Kidney, Liver

Publications for Chronic Intestinal Vascular Insufficiency

Articles related to Chronic Intestinal Vascular Insufficiency:

(show top 50) (show all 408)
# Title Authors PMID Year
1
How to manage chronic mesenteric ischemia? A deliberated strategy. 61
31580204 2020
2
The use of an upper extremity hemodialysis access site for stenting of the superior mesenteric artery for chronic mesenteric ischemia. 61
31660460 2019
3
Validation of a score chart to predict the risk of chronic mesenteric ischemia and development of an updated score chart. 61
31700639 2019
4
Superior mesenteric artery endarterectomy for chronic mesenteric ischemia: A viable alternative in poor candidates for endovascular interventions. 61
31699006 2019
5
Gastroscopy assisted laser Doppler flowmetry and visible light spectroscopy in patients with chronic mesenteric ischemia. 61
31560225 2019
6
[Endovascular treatment of chronic mesenteric ischemia]. 61
31474341 2019
7
Abdominal Pain in the Elderly: An Unusual Case of Chronic Mesenteric Ischemia in the Emergency Department. 61
31403102 2019
8
Renal Autotransplant and Celiac Artery Bypass for Aneurysmal Degeneration Related to Neurofibromatosis Type 1. 61
31043138 2019
9
Weight Loss: A Significant Cue To The Diagnosis of Chronic Mesenteric Ischemia. 61
31598442 2019
10
The radiologist's guide to duplex ultrasound assessment of chronic mesenteric ischemia. 61
31410506 2019
11
Laparoscopic Surgery in Chronic Mesenteric Ischemia: Release of the Superior Mesenteric Artery from the Median Arcuate Ligament Using the Transperitoneal Left Retrorenal Approach. 61
31009713 2019
12
Covered stents versus Bare-metal stents in chronic atherosclerotic Gastrointestinal Ischemia (CoBaGI): study protocol for a randomized controlled trial. 61
31429792 2019
13
"Aortoiliac-Mesenteric Steal Syndrome" Treated with Inferior Mesenteric to Common Iliac Artery Transposition. 61
30802588 2019
14
Improving midterm results justify the continued use of bare-metal stents for endovascular therapy for chronic mesenteric ischemia. 61
31327617 2019
15
Prevalence and Impact of Malnutrition in Patients Surgically Treated for Chronic Mesenteric Ischemia. 61
31009732 2019
16
A Rare Case of Ischemia-Reperfusion Injury After Mesenteric Revascularization. 61
30982410 2019
17
Thirty-day readmission after endovascular or surgical revascularization for chronic mesenteric ischemia: Insights from the Nationwide Readmissions Database. 61
30739588 2019
18
Acute and Chronic Ischemic Disorders of the Small Bowel. 61
31065817 2019
19
Clinical management of chronic mesenteric ischemia. 61
31080602 2019
20
Intravascular Ultrasound-Assisted Endovascular Treatment of Mesenteric Malperfusion in a Multichannel Aortic Dissection With Full True Lumen Collapse. 61
30547707 2019
21
Detection of mesenteric ischemia by means of endoscopic visible light spectroscopy after luminal feeding. 61
30055157 2019
22
The Impact of Revascularisation on Quality of Life in Chronic Mesenteric Ischemia. 61
31781520 2019
23
[Operative treatment of acute mesenteric ischaemia]. 61
30540513 2018
24
ACR Appropriateness Criteria® Imaging of Mesenteric Ischemia. 61
30392602 2018
25
Superior mesenteric artery stenting using embolic protection device for treatment of acute or chronic mesenteric ischemia. 61
29685508 2018
26
[Chronic Mesenteric Ischemia]. 61
30286488 2018
27
Spontaneous Isolated Inferior Mesenteric Artery Dissection With Chronic Mesenteric Ischemia: Case Report and Endovascular Management. 61
29716480 2018
28
Persistent symptom relief after revascularization in patients with single-artery chronic mesenteric ischemia. 61
29523436 2018
29
"Mesenteric Steal" Physiology as a Cause of Claudication and Chronic Mesenteric Ischemia. 61
29777839 2018
30
[Operative revascularization of visceral arteries in chronic mesenteric ischemia]. 61
29808329 2018
31
Exertional Abdominal Pain as a Rare Presenting Manifestation of Chronic Mesenteric Ischemia from a Single Mesenteric Vessel Stenosis. 61
29758324 2018
32
Multicenter study of retrograde open mesenteric artery stenting through laparotomy for treatment of acute and chronic mesenteric ischemia. 61
29548812 2018
33
Celiac Plexus Block as a Predictor of Surgical Outcome for Sympathetically Mediated Abdominal Pain in a Case of Suspected Median Arcuate Ligament Syndrome: A Case Report. 61
29634547 2018
34
Improved mortality in treatment of patients with endovascular interventions for chronic mesenteric ischemia. 61
29395425 2018
35
[Modern treatment of mesenteric ischemia]. 61
29776790 2018
36
A systematic review and meta-analysis of endovascular versus open surgical revascularization for chronic mesenteric ischemia. 61
29571626 2018
37
Quality Improvement Guidelines for Mesenteric Angioplasty and Stent Placement for the Treatment of Chronic Mesenteric Ischemia. 61
29574024 2018
38
Impact of Body Mass Index on Outcomes after Mesenteric Revascularization for Chronic Mesenteric Ischemia. 61
29217441 2018
39
A Nonsurgical Approach to Mesenteric Vascular Disease. 61
29419563 2018
40
Mesenteric Ischemia. 61
29413213 2018
41
Symptomatic Celiomesenteric Trunk: Variable Presentations and Outcomes in 2 Patients. 61
29556150 2018
42
Bifurcated Stent Technique: A Viable Option for Treatment of Patients With Unusual Anatomy Presenting With Combined Chronic Mesenteric Ischemia and Diffuse Ischemic Gastric Ulcers. 61
29121843 2018
43
Effective kissing stent to severe stenosis of the superior mesenteric artery replacing the common hepatic artery. 61
30652149 2018
44
Use of REBOA to stabilize in-hospital iatrogenic intra-abdominal hemorrhage. 61
30306138 2018
45
Reversal of Acute Mesenteric Ischemia by Salvation of the Meandering Mesenteric Artery with Stenting of the Left Internal Iliac Artery. 61
28890058 2018
46
Indications to open surgical revascularization of visceral arteries in the endovascular era. 61
30646738 2018
47
Patients with chronic mesenteric ischemia have an altered sublingual microcirculation. 61
30425547 2018
48
Surgical and Endovascular Management of Patients with Chronic Mesenteric Ischemia: A Single Center Experience. 61
29336771 2017
49
Endovascular Versus Surgical Revascularization for Chronic Mesenteric Ischemia: Insights From the National Inpatient Sample Database. 61
29217008 2017
50
Endovascular-First Approach for Chronic Mesenteric Ischemia: The Critical Need for Reporting Standards and High-Grade Evidence. 61
29217009 2017

Variations for Chronic Intestinal Vascular Insufficiency

Expression for Chronic Intestinal Vascular Insufficiency

Search GEO for disease gene expression data for Chronic Intestinal Vascular Insufficiency.

Pathways for Chronic Intestinal Vascular Insufficiency

Pathways related to Chronic Intestinal Vascular Insufficiency according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.98 ACSL6 ACSL5
2 10.76 ACSL6 ACSL5
3 10.3 ACSL6 ACSL5
4 9.88 ACSL6 ACSL5

GO Terms for Chronic Intestinal Vascular Insufficiency

Biological processes related to Chronic Intestinal Vascular Insufficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 potassium ion import across plasma membrane GO:1990573 9.4 ATP4A ATP12A
2 long-chain fatty acid metabolic process GO:0001676 9.37 ACSL6 ACSL5
3 long-chain fatty-acyl-CoA biosynthetic process GO:0035338 9.32 ACSL6 ACSL5
4 cellular sodium ion homeostasis GO:0006883 9.26 ATP4A ATP12A
5 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.16 ATP4A ATP12A
6 sodium ion export across plasma membrane GO:0036376 8.96 ATP4A ATP12A
7 cellular potassium ion homeostasis GO:0030007 8.62 ATP4A ATP12A

Molecular functions related to Chronic Intestinal Vascular Insufficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 acyl-CoA ligase activity GO:0003996 9.4 ACSL6 ACSL5
2 long-chain fatty acid-CoA ligase activity GO:0004467 9.37 ACSL6 ACSL5
3 sodium:potassium-exchanging ATPase activity GO:0005391 9.32 ATP4A ATP12A
4 decanoate-CoA ligase activity GO:0102391 9.26 ACSL6 ACSL5
5 arachidonate-CoA ligase activity GO:0047676 9.16 ACSL6 ACSL5
6 potassium-transporting ATPase activity GO:0008556 8.96 ATP4A ATP12A
7 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP4A ATP12A

Sources for Chronic Intestinal Vascular Insufficiency

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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