MCID: CHR089
MIFTS: 72

Chronic Kidney Failure

Categories: Nephrological diseases, Genetic diseases

Aliases & Classifications for Chronic Kidney Failure

MalaCards integrated aliases for Chronic Kidney Failure:

Name: Chronic Kidney Failure 38 12
Chronic Kidney Disease 12 29 6 43 3 15 63
Kidney Failure, Chronic 44 73
Ckd 12 3
Chronic Renal Failure Syndrome 12
Chronic Kidney Disease Stage 5 73
Renal Failure - Chronic 12
Chronic Kidney Diseases 73
Chronic Renal Disease 12
Chronic Renal Failure 76
Renal Failure Chronic 55
Crf 12

Classifications:



External Ids:

Disease Ontology 12 DOID:784
ICD10 33 N18.9 N18
ICD9CM 35 585.6
MeSH 44 D007676
NCIt 50 C9438

Summaries for Chronic Kidney Failure

MedlinePlus : 43 You have two kidneys, each about the size of your fist. Their main job is to filter your blood. They remove wastes and extra water, which become urine. They also keep the body's chemicals balanced, help control blood pressure, and make hormones. Chronic kidney disease (CKD) means that your kidneys are damaged and can't filter blood as they should. This damage can cause wastes to build up in your body. It can also cause other problems that can harm your health. Diabetes and high blood pressure are the most common causes of CKD. The kidney damage occurs slowly over many years. Many people don't have any symptoms until their kidney disease is very advanced. Blood and urine tests are the only way to know if you have kidney disease. Treatments cannot cure kidney disease, but they may slow kidney disease. They include medicines to lower blood pressure, control blood sugar, and lower cholesterol. CKD may still get worse over time. Sometimes it can lead to kidney failure. If your kidneys fail, you will need dialysis or a kidney transplantation. You can take steps to keep your kidneys healthier longer: Choose foods with less salt (sodium) Control your blood pressure; your health care provider can tell you what your blood pressure should be Keep your blood sugar in the target range, if you have diabetes Limit the amount of alcohol you drink Choose foods that are healthy for your heart: fruits, vegetables, whole grains, and low-fat dairy foods Lose weight if you are overweight Be physically active Don't smoke NIH: National Institute of Diabetes and Digestive and Kidney Diseases

MalaCards based summary : Chronic Kidney Failure, also known as chronic kidney disease, is related to peritonitis and hyporeninemic hypoaldosteronism, and has symptoms including cloudy (hemodialysis) (peritoneal) dialysis effluent An important gene associated with Chronic Kidney Failure is COL4A5 (Collagen Type IV Alpha 5 Chain), and among its related pathways/superpathways are HIF-1 signaling pathway and Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics. The drugs Capsaicin and Simvastatin have been mentioned in the context of this disorder. Affiliated tissues include Bone and Adipose, and related phenotypes are cardiovascular system and homeostasis/metabolism

PubMed Health : 63 About chronic kidney disease: Our kidneys are vital organs that clean our blood and affect many different bodily functions. Various medical conditions can cause the kidneys to stop working properly for a short time – for example, if blood isn’t pumped around the body properly or if an enlarged prostate or kidney stones make urine build up in the kidneys.But if the kidneys still aren’t working at full capacity more than three months later or are permanently damaged, then the problem is considered to be chronic kidney disease. The most common causes in adults are diabetes and high blood pressure.Older people are especially prone to developing chronic kidney disease. It often goes unnoticed for a long time because poorly functioning kidneys don’t cause any problems at first.Treatment mostly aims to stop the kidney disease from getting worse, or at least delay the process. It is also important to treat complications such as anemia, acidosis or changes in bone metabolism. If the kidneys fail completely, dialysis or a kidney transplant can prolong the person’s life.

Wikipedia : 76 Chronic kidney disease (CKD) is a type of kidney disease in which there is gradual loss of kidney... more...

Related Diseases for Chronic Kidney Failure

Diseases in the Kidney Disease family:

Acute Kidney Failure Chronic Kidney Failure
Renal Infectious Disease Ren-Related Kidney Disease

Diseases related to Chronic Kidney Failure via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 168)
# Related Disease Score Top Affiliating Genes
1 peritonitis 31.3 ALB B2M CRP
2 hyporeninemic hypoaldosteronism 31.3 ACE REN
3 hyperphosphatemia 31.1 FGF23 PTH VDR
4 pyelonephritis 31.0 ACE ALB CRP
5 renal osteodystrophy 31.0 FGF23 PTH VDR
6 hemorrhagic fever with renal syndrome 31.0 ALB B2M CRP
7 hypoaldosteronism 31.0 ACE REN
8 hyperuricemia 30.9 CRP INS REN
9 hyperparathyroidism 30.9 EPO FGF23 PTH VDR
10 secondary hyperparathyroidism of renal origin 30.9 ALB EPO FGF23 PTH VDR
11 myeloma, multiple 30.8 ALB B2M CRP EPO TUG1
12 interstitial nephritis 30.8 ACE AGT ALB CRP REN
13 heart disease 30.5 ACE ALB CRP CST3 INS REN
14 diabetes mellitus, noninsulin-dependent 30.3 ACE AGT ALB CRP INS LEP
15 diabetes mellitus 30.1 ACE AGT ALB CRP EPO INS
16 end stage renal failure 30.1 ACE AGT ALB COL4A5 CRP CST3
17 kidney disease 29.1 ACE AGT ALB B2M COL4A5 CRP
18 paramyloidosis 11.3 ALB TTR
19 kwashiorkor 11.3 ALB TF TTR
20 marasmus 11.3 ALB TF TTR
21 median rhomboid glossitis 11.3 B2M TF TTR
22 burns 11.3 ALB INS TTR
23 pure red-cell aplasia 11.2 ALB EPO TF
24 fetal erythroblastosis 11.2 ALB EPO INS
25 hypertensive encephalopathy 11.2 ACE EPO REN
26 autonomic nervous system disease 11.2 ALB INS TTR
27 renal artery disease 11.2 ACE EPO REN
28 retinitis pigmentosa 7 11.2 B2M TF TTR
29 folic acid deficiency anemia 11.2 CRP EPO TF
30 testicular yolk sac tumor 11.2 ALB TF TTR
31 chronic ulcer of skin 11.2 ALB CRP TTR
32 decubitus ulcer 11.2 ALB CRP TTR
33 uremic neuropathy 11.2 B2M EPO PTH
34 abdominal obesity-metabolic syndrome quantitative trait locus 2 11.2 CRP INS LEP
35 protein-energy malnutrition 11.2 ALB LEP TF TTR
36 pyelitis 11.2 B2M CRP REN
37 urinary tract obstruction 11.2 ALB B2M REN
38 malignant otitis externa 11.2 CRP INS
39 amyloidosis aa 11.2 B2M CRP TTR
40 obstructive jaundice 11.2 ALB REN TTR
41 orthostatic proteinuria 11.2 ACE ALB B2M REN
42 renal hypertension 11.2 ACE ALB EPO REN
43 renal artery obstruction 11.2 ACE REN
44 adenine phosphoribosyltransferase deficiency 11.1
45 oligomeganephronia 11.1
46 malignant hypertension 11.1 ACE AGT REN
47 dysentery 11.1 ALB CRP TF TTR
48 benign essential hypertension 11.1 ALB REN
49 pure autonomic failure 11.1 ACE EPO REN TTR
50 immunodeficiency 43 11.1 ALB B2M

Comorbidity relations with Chronic Kidney Failure via Phenotypic Disease Network (PDN): (show top 50) (show all 116)


Acquired Thrombocytopenia Active Peptic Ulcer Disease
Acute Cystitis Acute Kidney Failure
Acute Myocardial Infarction Acute Pancreatitis
Acute Proliferative Glomerulonephritis Acute Vascular Insufficiency of Intestine
Alcoholic Liver Cirrhosis Amyloidosis
Aortic Valve Disease 1 Bacteremia 2
Benign Essential Hypertension Benign Hypertensive Renal Disease
Benign Renovascular Hypertension Bladder Cancer
Bladder Neck Obstruction Bleeding Disorder, Platelet-Type, 11
Bronchitis Bronchopneumonia
Candidiasis Cardiac Arrest
Cardiogenic Shock Cerebral Atherosclerosis
Cerebrovascular Disease Chronic Intestinal Vascular Insufficiency
Chronic Myocardial Ischemia Chronic Rapidly Progressive Glomerulonephritis
Cystitis Decubitus Ulcer
Deficiency Anemia Dermatomycosis
Diabetic Polyneuropathy Disseminated Intravascular Coagulation
Duodenitis Encephalopathy
Esophageal Candidiasis Esophageal Disease
Esophagitis Familial Atrial Fibrillation
First-Degree Atrioventricular Block Generalized Atherosclerosis
Goodpasture Syndrome Gout
Heart Disease Hemolytic-Uremic Syndrome
Hepatic Encephalopathy Hepatorenal Syndrome
Hydronephrosis Hyperparathyroidism

Graphical network of the top 20 diseases related to Chronic Kidney Failure:



Diseases related to Chronic Kidney Failure

Symptoms & Phenotypes for Chronic Kidney Failure

UMLS symptoms related to Chronic Kidney Failure:


cloudy (hemodialysis) (peritoneal) dialysis effluent

MGI Mouse Phenotypes related to Chronic Kidney Failure:

46 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.39 B2M ACE COL4A5 AGT CRP CST3
2 homeostasis/metabolism MP:0005376 10.36 B2M ACE COL4A5 AGT CRP CST3
3 hematopoietic system MP:0005397 10.25 B2M ACE COL4A5 EPO LEP FGF23
4 growth/size/body region MP:0005378 10.23 B2M ACE AGT LEP FGF23 MKS1
5 endocrine/exocrine gland MP:0005379 10.22 B2M ACE ALB PKD2 LEP FGF23
6 immune system MP:0005387 10.21 B2M ACE COL4A5 AGT CRP EPO
7 mortality/aging MP:0010768 10.16 B2M ACE COL4A5 AGT CST3 ALB
8 digestive/alimentary MP:0005381 10.1 B2M ALB LEP FGF23 MKS1 INS
9 liver/biliary system MP:0005370 9.97 EPO B2M ACE AGT ALB LEP
10 muscle MP:0005369 9.76 AGT CST3 ALB EPO LEP INS
11 renal/urinary system MP:0005367 9.73 ACE COL4A5 AGT ALB FGF23 MKS1
12 reproductive system MP:0005389 9.36 B2M ACE AGT CST3 LEP FGF23

Drugs & Therapeutics for Chronic Kidney Failure

PubMedHealth treatment related to Chronic Kidney Failure: 63

The most suitable treatment for chronic kidney disease will depend on the cause and stage of the disease, as well as on the person’s life circumstances and preferences.If the kidneys are still working at a nearly normal level, treatment should aim to stop or slow down the progression of the disease. This is mainly done using medication to lower blood pressure levels and prevent cardiovascular disease. If you have diabetes, it's important to regulate your blood sugar levels.If complications such as anemia or bone metabolism disorders have already occurred, then more medications are used – such as medicines that contain iron or stimulate the production of blood, as well as medications called “phosphate binders.” If there is too much acid in your body, bicarbonates are used. In addition to the medication, the treatment will include a diet suited to the stage of the disease, drinking the right amounts of liquids and physical exercise.Dialysis or a kidney transplant are considered if the kidneys fail completely.In the vast majority of people with complete kidney failure, at least one of these options is possible. Some people make a conscious decision not to use either, accepting the fact that they could die soon afterwards. Palliative treatment may then be suitable for them – enabling a final phase of life that is as pleasant as possible.

Drugs for Chronic Kidney Failure (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 936)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Capsaicin Approved Phase 4 404-86-4 1548943
2
Simvastatin Approved Phase 4,Phase 3,Not Applicable 79902-63-9 54454
3
Peginterferon alfa-2b Approved Phase 4,Phase 1,Not Applicable 99210-65-8, 215647-85-1
4
Ribavirin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 36791-04-5 37542
5
Nitric Oxide Approved Phase 4,Phase 1,Phase 2,Not Applicable 10102-43-9 145068 160954
6
Digoxin Approved Phase 4 20830-75-5 30322 2724385
7
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-78-2 2244
8
Acetylcysteine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 616-91-1 12035
9
Clopidogrel Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 120202-66-6, 113665-84-2 60606
10
Ticagrelor Approved Phase 4,Phase 3,Phase 1,Phase 2 274693-27-5 9871419
11
Ticlopidine Approved Phase 4,Phase 3,Phase 2,Phase 1 55142-85-3 5472
12
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 3,Not Applicable 113775-47-6 68602 5311068
13
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable 2078-54-8 4943
14
Ursodeoxycholic acid Approved, Investigational Phase 4 128-13-2 31401
15
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
16
Spironolactone Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 1952-01-7, 52-01-7 5833
17
alemtuzumab Approved, Investigational Phase 4,Phase 1,Phase 2,Not Applicable 216503-57-0
18
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1994-09-7, 94-09-7 2337
19
Tacrolimus Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 104987-11-3 445643 439492
20
Bupivacaine Approved, Investigational Phase 4,Phase 3,Not Applicable 2180-92-9, 38396-39-3 2474
21
Lidocaine Approved, Vet_approved Phase 4,Not Applicable 137-58-6 3676
22
Pregabalin Approved, Illicit, Investigational Phase 4 148553-50-8 5486971
23
Alendronate Approved Phase 4,Not Applicable 121268-17-5, 66376-36-1 2088
24
Furosemide Approved, Vet_approved Phase 4,Phase 3,Phase 1,Not Applicable 54-31-9 3440
25
Hydrochlorothiazide Approved, Vet_approved Phase 4,Phase 3,Phase 1,Not Applicable,Early Phase 1 58-93-5 3639
26
Acarbose Approved, Investigational Phase 4 56180-94-0 441184
27
Pioglitazone Approved, Investigational Phase 4,Phase 2,Not Applicable 111025-46-8 4829
28
Ezetimibe Approved Phase 4,Phase 3,Not Applicable 163222-33-1 150311
29 Benidipine Approved, Investigational Phase 4 105979-17-7
30
Fosinopril Approved Phase 4,Phase 3,Not Applicable 98048-97-6 55891
31
Angiotensin II Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
32
Perindopril Approved Phase 4 107133-36-8, 82834-16-0 107807
33
Valsartan Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 137862-53-4 60846
34
Iron Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 7439-89-6 23925
35
Candesartan cilexetil Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 145040-37-5 2540
36
Enalapril Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 75847-73-3 5362032 40466924
37
Enalaprilat Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 76420-72-9 6917719
38
Pitavastatin Approved Phase 4,Phase 3,Phase 1 147511-69-1, 147526-32-7 6366718 5282452
39
Amlodipine Approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 88150-42-9 2162
40
Telmisartan Approved, Investigational Phase 4,Phase 3,Not Applicable 144701-48-4 65999
41
Heparin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 9005-49-6 772 46507594
42
Allopurinol Approved Phase 4,Phase 3,Not Applicable 315-30-0 2094
43
Everolimus Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 159351-69-6 6442177
44
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 22916-47-8 4189
45
Sirolimus Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 53123-88-9 5284616 6436030 46835353
46
Colchicine Approved Phase 4,Phase 2 64-86-8 6167 2833
47
Mycophenolate mofetil Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 128794-94-5 5281078
48
Mycophenolic acid Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 24280-93-1 446541
49 Taurolidine Approved, Investigational Phase 4,Phase 3 19388-87-5
50
Basiliximab Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 152923-56-3, 179045-86-4

Interventional clinical trials:

(show top 50) (show all 3578)
# Name Status NCT ID Phase Drugs
1 Qutenza for Critical Ischaemia in End Stage Renal Failure Unknown status NCT01704339 Phase 4 QUTENZA
2 Simvastatin Effect on End Stage Renal Failure Patients Treated by Peritoneal Dialysis Unknown status NCT00291863 Phase 4 Simvastatin
3 Inspiratory Muscle Training in Patients With End Stage Renal Failure Unknown status NCT01347775 Phase 4
4 Effect of Sodium Rinsing Fluid on Blood Pressure and Interdialytic Weight Change in Hemodialysis Patients Unknown status NCT02590081 Phase 4 Dextrose 5%;normal saline
5 A Pilot Study to Treat Patients With Chronic Hepatitis C Virus (HCV) Genotype 1 and End-Stage Renal Disease (ESRD) Unknown status NCT01731301 Phase 4 Ribavirin;Peginterferon;Boceprevir
6 Far Infrared Therapy on AV Fistula Flow, Endothelial Function and Echocardiography in ESRD Patients Unknown status NCT01138254 Phase 4
7 Marinobufagenin as a Target for DIGIBIND in Hypertensive Patients With End-stage Renal Disease Unknown status NCT00852787 Phase 4 Digoxin immune fab;Placebo
8 Aspirin in the Prevention of Cardiovascular Events in Hemodialysis Patients Unknown status NCT01198379 Phase 4 aspirin;Placebo
9 Effect of Hydration With Sodium Bicarbonate for Long-Term Clinical Outcomes in Patients With Chronic Kidney Disease Undergoing an Emergent Coronary Procedure Unknown status NCT00716001 Phase 4 N-acetylcysteine
10 Platelet Resistance With Ticagrelor or Standard-Dose Clopidogrel Among CKD and ACS Patients Unknown status NCT02459288 Phase 4 Clopidogrel first;Ticagrelor first
11 NAC in Preventing CIN in CRF Patients Who Need Enhanced CT Scan in ED Unknown status NCT00501475 Phase 4 NAC Bicarbonate
12 Dexmedetomidine and Propofol As Sole Sedative Agent for Patients Undergoing Arteriovenous Fistula Surgery Unknown status NCT02447796 Phase 4 Propofol;Dexmedetomidine
13 Effects of On-Line Hemodiafiltration(HDF) on Vascular Health in Chronic Hemodialysis Patients Unknown status NCT00532597 Phase 4
14 A Study of Ferric Citrate to Improve Inflammation and Lipid Levels Unknown status NCT02661295 Phase 4 Ferric Citrate
15 Effect of Ursodeoxycholic Acid on Peritoneal Function in Patients on Peritoneal Dialysis Unknown status NCT02338635 Phase 4 Ursodeoxycholic Acid
16 Body Composition Monitor in Hemodialysis Patients Unknown status NCT01103167 Phase 4
17 Effect of Different Hemodialysis Modality on Adiponectin,Vascular Function and Clinical Prognosis Unknown status NCT00155363 Phase 4
18 Effects of an Exercise Program in Patients With Hypertensive Chronic Kidney Disease Unknown status NCT01155128 Phase 4
19 Opioids in Chronic Kidney Disease Patients Undergoing Hemodialysis Unknown status NCT02452437 Phase 4 Oxycodone
20 Hypervolemia in ESRD Patients in Zonguldak (Prospective Study) Unknown status NCT01468363 Phase 4
21 Cardiovascular Protective Effect of Spironolactone in Hemodialysis Unknown status NCT00277693 Phase 4 Spironolactone (drug)
22 The Canadian Prevention of Renal and Cardiovascular Endpoints Trial Unknown status NCT00231803 Phase 4
23 Anti-Oxidant Effect on Peritoneal Membrane in Peritoneal Dialysis (PD) Patients Unknown status NCT01111422 Phase 4 N-acetylcysteine
24 Standard Versus Prolonged-release Tacrolimus Monotherapy After Alemtuzumab Induction in Kidney Transplantation Unknown status NCT00807144 Phase 4 Tacrolimus (Kidney transplant maintenance immunosuppression);Kidney transplant maintenance immunosuppression
25 RAAS Inhibitor Drugs in Dialysis Patients Unknown status NCT01635387 Phase 4 aliskiren
26 More Frequent Dialysis (>3 Treatments Per Week) Unknown status NCT00575497 Phase 4
27 2% Lidocaine Plus 0.5% Bupivacaine Versus 0.5% Bupivacaine in Brachial Block for Creation of Arteriovenous (AV) Fistula Unknown status NCT00993746 Phase 4 Bupivacaine plus lidocaine;Bupivacaine 30 ml
28 The Effect and Safety of the Seasonal Trivalent Influenza Vaccine in Chronic Kidney Disease Patients Not on Dialysis Unknown status NCT02105519 Phase 4
29 Far Infrared Therapy on Peripheral Artery Disease in Hemodialysis Patients Unknown status NCT01095549 Phase 4
30 Efficacy of Pregabalin in the Management of Chronic Uremic Pruritus Unknown status NCT01073501 Phase 4 Pregabalin;Placebo
31 Clinical Impact of Bacteriuria on Chronic Inflammation in Asymptomatic Hemodialysis Patients Unknown status NCT01570556 Phase 4
32 Clinical Trial Technology Development for the Validation of Surrogate Prognostic Markers in Patients With Diabetic Nephropathy Unknown status NCT01673204 Phase 4 Calcitriol;Placebo
33 Alendronate for Vascular Calcification in Peritoneal Dialysis Patients? Unknown status NCT00299572 Phase 4 alendronate (Fosamax)
34 Effect of Intravenous Acetadote on Incidence of Contrast Induced Nephropathy Unknown status NCT00939913 Phase 4 intravenous NAC;Placebo
35 Clinical Trial to Compare Effectiveness of Diuretics in Hemodialysis Patients With Residual Renal Function Unknown status NCT01977430 Phase 4 Hydrochlorothiazide and furosemide
36 Thiazolidinedione (TZD) on the Diabetic Retinopathy and Nephropathy Unknown status NCT01175486 Phase 4 Actos (Pioglitazone);Acarbose
37 The Effects of Acetylcysteine on Alleviating Damage of Oxidative Stress in Hemodialysis Patients Unknown status NCT00247507 Phase 4 acetylcysteine
38 Ezetimibe/Simvastatin Combination in Proteinuric Nephropathy Unknown status NCT00861731 Phase 4 simvastatin;EZE/simvastatin;EZE/simvastatin
39 Benidipine and Hydrochlorothiazide in Fosinopril Treated Chronic Kidney Disease Patients With Hypertension Unknown status NCT02646397 Phase 4 Fosinopril;Benidipine;Hydrochlorothiazide
40 Revascularization of Renal Artery Stenosis Versus Medical Therapy for the Treatment of Ischemic Nephropathy Unknown status NCT01023373 Phase 4 Medical treatment
41 Effect of Valsartan vs Perindopril on HOMA-IR Index in Patients With Chronic Kidney Disease Unknown status NCT02299310 Phase 4 Valsartan;Perindopril
42 Efficacy and Safety of Abelmoschus Manihot for Chronic Kidney Disease Unknown status NCT02231138 Phase 4 Abelmoschus manihot (AM)
43 Keto-/Amino Acid Supplemented Low Protein Diet in Patients With Chronic Kidney Disease Unknown status NCT00364884 Phase 4 ketoaminoacid
44 Efficacy and Safety of Simvast Controlled Release (CR) and Zocor in Chronic Kidney Disease(CKD) Stage 3, 4 and 5 Patients With Hyperlipidemia Unknown status NCT01564875 Phase 4 Simvast CR;Zocor
45 Nutritional Therapy to Prevent Progression of Acute Kidney Injury to Chronic Kidney Disease Unknown status NCT02831062 Phase 4
46 Pure Red Cell Aplasia in Patients With Chronic Kidney Disease and in Use of Epoetin Alfa Unknown status NCT02648126 Phase 4
47 The Effects of AST-120 on Endothelial Dysfunction in Patients With Chronic Kidney Disease Unknown status NCT01157260 Phase 4 Kremezin
48 Intravenous Iron in Patients With Anemia of Chronic Kidney Disease Unknown status NCT00204256 Phase 4 Iron sucrose
49 Vitamin K2 and Vessel Calcification in Chronic Kidney Disease Patients Unknown status NCT01101698 Phase 4 Vitamin K2+10μg cholecalciferol;Vitamin D
50 The Prevention of Contrast Induced Nephropathy by Sarpogrelate in Patients With Chronic Kidney Disease Unknown status NCT01165567 Phase 4 sarpogrelate

Search NIH Clinical Center for Chronic Kidney Failure

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Chronic Kidney Failure cell therapies at LifeMap Discovery.

Cochrane evidence based reviews: kidney failure, chronic

Genetic Tests for Chronic Kidney Failure

Genetic tests related to Chronic Kidney Failure:

# Genetic test Affiliating Genes
1 Chronic Kidney Disease 29

Anatomical Context for Chronic Kidney Failure

MalaCards organs/tissues related to Chronic Kidney Failure:

41
Kidney, Bone, Heart, Endothelial, Liver, Testes, Neutrophil
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Chronic Kidney Failure:
# Tissue Anatomical CompartmentCell Relevance
1 Bone Bone Marrow Bone Marrow Stromal Cells Potential therapeutic candidate
2 Adipose Subcutaneous White Adipose Mesenchymal Stem Cells Potential therapeutic candidate
3 Kidney Proximal Tubule Proximal Tubule Cells Potential therapeutic candidate, affected by disease
4 Adipose Subcutaneous White Adipose Stromal Cells Potential therapeutic candidate

Publications for Chronic Kidney Failure

Articles related to Chronic Kidney Failure:

(show top 50) (show all 2119)
# Title Authors Year
1
Hepcidin and proinflammatory markers inA children with chronic kidney disease: AA case-control studya8c. ( 29451472 )
2018
2
Cinacalcet versus Placebo for secondary hyperparathyroidism in chronic kidney disease patients: a meta-analysis of randomized controlled trials and trial sequential analysis. ( 29449603 )
2018
3
Does Chronic Kidney Disease-Induced Cognitive Impairment Affect Driving Safety? ( 29977582 )
2018
4
Treatment of Hyperuricemia in Chronic Kidney Disease. ( 29393124 )
2018
5
Hyperuricemia and Progression of Chronic Kidney Disease: Role of Phenotype Transition of Renal Tubular and Endothelial Cells. ( 29393109 )
2018
6
Chronic kidney disease and acquired mitochondrial myopathy. ( 29266014 )
2018
7
Chronic kidney disease mortality trends in selected Central America countries, 1997-2013: clues to an epidemic of chronic interstitial nephritis of agricultural communities. ( 29437864 )
2018
8
Differential Clinical Outcomes Between Angiographic Complete Versus Incomplete Coronary Revascularization, According to the Presence of Chronic Kidney Disease in the Drug-Eluting Stent Era. ( 29449272 )
2018
9
Anti-Transforming Growth Factor I^ IgG Elicits a Dual Effect on Calcium Oxalate Crystallization and Progressive Nephrocalcinosis-Related Chronic Kidney Disease. ( 29651290 )
2018
10
Clinicopathological predictors for progression of chronic kidney disease in nephrosclerosis: a biopsy-based cohort study. ( 29788462 )
2018
11
Inhaling Difluoroethane Computer Cleaner Resulting in Acute Kidney Injury and Chronic Kidney Disease. ( 29977633 )
2018
12
A case report of remission of refractory membranous nephropathy progressing to stage 4 chronic kidney disease using low-dose rituximab: A long-term follow-up. ( 29924035 )
2018
13
Cost-Effectiveness of First-Line Sevelamer and Lanthanum versus Calcium-Based Binders for Hyperphosphatemia of Chronic Kidney Disease. ( 29566839 )
2018
14
Prediction of chronic kidney disease after acute kidney injury in ICU patients: study protocol for the PREDICT multicenter prospective observational study. ( 29980878 )
2018
15
Diagnosis and Treatment of Metabolic Acidosis in Patients with Chronic Kidney Disease - Position Statement of the Working Group of the Polish Society of Nephrology. ( 29895022 )
2018
16
Hepatitis C virus infection in chronic kidney disease: paradigm shift in management. ( 29961309 )
2018
17
Phosphate stimulates myotube atrophy through autophagy activation: evidence of hyperphosphatemia contributing to skeletal muscle wasting in chronic kidney disease. ( 29486729 )
2018
18
Intradialytic neuromuscular electrical stimulation reduces DNA damage in chronic kidney failure patients: a randomized controlled trial. ( 29529880 )
2018
19
Effector I^I' T cells in human renal fibrosis and chronic kidney disease. ( 29897565 )
2018
20
Using Machine Learning Algorithms to Predict Risk for Development of Calciphylaxis in Patients with Chronic Kidney Disease. ( 29888059 )
2018
21
No difference in renal injury and fibrosis between wild-type and NOD1/NOD2 double knockout mice with chronic kidney disease induced by ureteral obstruction. ( 29609537 )
2018
22
Prevalence of Chronic Kidney Disease in Iranian General Population: A Meta-Analysis and Systematic Review. ( 29974630 )
2018
23
Evaluation of Serum Symmetric Dimethylarginine Concentration as a Marker for Masked Chronic Kidney Disease in Cats With Hyperthyroidism. ( 29377360 )
2018
24
Proton Pump Inhibitors and Chronic Kidney Disease: Is It Related to the Accumulation of Toxic Breakdown Products Spontaneously Formed in the Enteric-Protected Tablets? ( 29452088 )
2018
25
A novel UMOD gene mutation associated with chronic kidney failure at a young age. ( 29424336 )
2018
26
Baseline Characteristics of the Autosomal Dominant Polycystic Kidney Disease Subcohort of the KoreaN Cohort Study for Outcomes in Patients With Chronic Kidney Disease (KNOW-CKD). ( 29797773 )
2018
27
Monocyte count modifies the association between chronic kidney disease and risk ofA deatha8c. ( 29974856 )
2018
28
Loop diuretics are associated with greater risk of sarcopenia in patients with non-dialysis-dependent chronic kidney disease. ( 29447254 )
2018
29
Initial surgical results of 500 Parathyroidectomies for Hyperparathyroidism related to chronic kidney disease - mineral and bone disorder. ( 29944161 )
2018
30
Leptin and ghrelin in chronic kidney disease: their associations with protein-energy wasting. ( 29980850 )
2018
31
Risk Factors for Carotid Artery Disease and Chronic Kidney Disease: Same or Unique? ( 29405657 )
2018
32
Apolipoprotein M in patients with chronic kidney disease. ( 29980057 )
2018
33
Malnutrition in Chronic Kidney Disease. ( 29974043 )
2018
34
Cardiac Magnetic Resonance Imaging of the Myocardium in Chronic Kidney Disease. ( 29444516 )
2018
35
Efficacy and safety of dual antiplatelet therapy after coronary stenting in patients with chronic kidney disease. ( 29447770 )
2018
36
Urinary orosomucoid is associated with progressive chronic kidney disease stage in patients with sickle cell anemia. ( 29327376 )
2018
37
EQ-5D-Y for the assessment of health-related quality of life among Taiwanese youth with mild-to-moderate chronic kidney disease. ( 29447362 )
2018
38
Modulation of intestinal microbiota, control of nitrogen products and inflammation by pre/probiotics in chronic kidney disease: a systematic review. ( 29974784 )
2018
39
Alkaline Phosphatases in the Complex Chronic Kidney Disease-Mineral and Bone Disorders. ( 29445837 )
2018
40
Dietary Treatment of Metabolic Acidosis in Chronic Kidney Disease. ( 29677110 )
2018
41
Pharmacological induction of hypoxia-inducible transcription factor ARNT attenuates chronic kidney failure. ( 29664738 )
2018
42
Prevention and treatment of hyperphosphatemia in chronic kidney disease. ( 29580635 )
2018
43
Progression of diabetes, ischemic heart disease, and chronic kidney disease in a three chronic conditions multistate model. ( 29914451 )
2018
44
Plasma triglycerides as a risk factor for chronic kidney disease in type 2 diabetes mellitus: Evidence from the northeastern of Thailand. ( 29448006 )
2018
45
Influence of concurrent chronic kidney disease on intraoperative parathyroid hormone monitoring during parathyroidectomy for primary hyperparathyroidism. ( 29128188 )
2018
46
The prevalence and association of chronic kidney disease and diabetes in liver cirrhosis using different estimated glomerular filtration rate equation. ( 29416767 )
2018
47
Intestinal secretion of indoxyl sulfate as a possible compensatory excretion pathway in chronic kidney disease. ( 29975986 )
2018
48
Blood pressure and heart rate variability are linked with hyperphosphatemia in chronic kidney disease patients. ( 29947550 )
2018
49
Ischaemic stroke, haemorrhage, and mortality in older patients with chronic kidney disease newly started on anticoagulation for atrial fibrillation: a population based study from UK primary care. ( 29444881 )
2018
50
Characterization of subclinical bacteriuria, bacterial cystitis, and pyelonephritis in dogs with chronic kidney disease. ( 29701531 )
2018