CKD
MCID: CHR089
MIFTS: 73

Chronic Kidney Failure (CKD)

Categories: Blood diseases, Bone diseases, Genetic diseases, Nephrological diseases

Aliases & Classifications for Chronic Kidney Failure

MalaCards integrated aliases for Chronic Kidney Failure:

Name: Chronic Kidney Failure 38 12
Chronic Kidney Disease 12 29 6 43 3 15 63
Kidney Failure, Chronic 44 73
Chronic Renal Disease 12 15
Ckd 12 3
Chronic Renal Failure Syndrome 12
Chronic Kidney Disease Stage 5 73
Renal Failure - Chronic 12
Chronic Kidney Diseases 73
Chronic Renal Failure 76
Renal Failure Chronic 55
Crf 12

Classifications:



External Ids:

Disease Ontology 12 DOID:784
ICD10 33 N18.9 N18
ICD9CM 35 585.6
MeSH 44 D007676
NCIt 50 C9438
SNOMED-CT 68 46177005 90688005

Summaries for Chronic Kidney Failure

MedlinePlus : 43 You have two kidneys, each about the size of your fist. Their main job is to filter your blood. They remove wastes and extra water, which become urine. They also keep the body's chemicals balanced, help control blood pressure, and make hormones. Chronic kidney disease (CKD) means that your kidneys are damaged and can't filter blood as they should. This damage can cause wastes to build up in your body. It can also cause other problems that can harm your health. Diabetes and high blood pressure are the most common causes of CKD. The kidney damage occurs slowly over many years. Many people don't have any symptoms until their kidney disease is very advanced. Blood and urine tests are the only way to know if you have kidney disease. Treatments cannot cure kidney disease, but they may slow kidney disease. They include medicines to lower blood pressure, control blood sugar, and lower cholesterol. CKD may still get worse over time. Sometimes it can lead to kidney failure. If your kidneys fail, you will need dialysis or a kidney transplantation. You can take steps to keep your kidneys healthier longer: Choose foods with less salt (sodium) Control your blood pressure; your health care provider can tell you what your blood pressure should be Keep your blood sugar in the target range, if you have diabetes Limit the amount of alcohol you drink Choose foods that are healthy for your heart: fruits, vegetables, whole grains, and low-fat dairy foods Lose weight if you are overweight Be physically active Don't smoke NIH: National Institute of Diabetes and Digestive and Kidney Diseases

MalaCards based summary : Chronic Kidney Failure, also known as chronic kidney disease, is related to end stage renal failure and calciphylaxis, and has symptoms including cloudy (hemodialysis) (peritoneal) dialysis effluent An important gene associated with Chronic Kidney Failure is COL4A5 (Collagen Type IV Alpha 5 Chain), and among its related pathways/superpathways are HIF-1 signaling pathway and Adipogenesis. The drugs Capsaicin and Simvastatin have been mentioned in the context of this disorder. Affiliated tissues include Bone and Adipose, and related phenotypes are cardiovascular system and homeostasis/metabolism

PubMed Health : 63 About chronic kidney disease: Our kidneys are vital organs that clean our blood and affect many different bodily functions. Various medical conditions can cause the kidneys to stop working properly for a short time – for example, if blood isn’t pumped around the body properly or if an enlarged prostate or kidney stones make urine build up in the kidneys.But if the kidneys still aren’t working at full capacity more than three months later or are permanently damaged, then the problem is considered to be chronic kidney disease. The most common causes in adults are diabetes and high blood pressure.Older people are especially prone to developing chronic kidney disease. It often goes unnoticed for a long time because poorly functioning kidneys don’t cause any problems at first.Treatment mostly aims to stop the kidney disease from getting worse, or at least delay the process. It is also important to treat complications such as anemia, acidosis or changes in bone metabolism. If the kidneys fail completely, dialysis or a kidney transplant can prolong the person’s life.

Wikipedia : 76 Chronic kidney disease (CKD) is a type of kidney disease in which there is gradual loss of kidney... more...

Related Diseases for Chronic Kidney Failure

Diseases in the Kidney Disease family:

Acute Kidney Failure Chronic Kidney Failure
Renal Infectious Disease Ren-Related Kidney Disease

Diseases related to Chronic Kidney Failure via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 734)
# Related Disease Score Top Affiliating Genes
1 end stage renal failure 33.1 ACE AGT ALB COL4A5 CRP EPO
2 calciphylaxis 32.4 ALB EPO FGF23 PTH VDR
3 hypoparathyroidism 31.8 FGF23 GATA3 PTH
4 deficiency anemia 31.3 ALB CRP EPO TF
5 hyperphosphatemia 31.3 FGF23 PTH VDR
6 bone disease 31.1 B2M FGF23 PTH VDR
7 arteries, anomalies of 31.0 ACE AGT ALB CRP INS LEP
8 vascular disease 30.9 ACE ALB CRP INS REN
9 myocardial infarction 30.9 ACE AGT ALB CRP INS REN
10 polycystic kidney disease 30.9 ACE PKD1 PKD2 REN
11 iron deficiency anemia 30.9 CRP EPO FGF23 TF
12 lipid metabolism disorder 30.9 ACE CRP INS LEP
13 sleep apnea 30.9 ACE CRP INS LEP REN
14 liver disease 30.9 ALB INS LEP PKD1 PKD2 TF
15 nephrolithiasis 30.9 FGF23 INS PTH VDR
16 autosomal dominant polycystic kidney disease 30.8 ACE AGT ALB FGF23 PKD1 PKD2
17 peripheral vascular disease 30.8 ACE ALB CRP
18 obstructive nephropathy 30.8 ACE AGT ALB REN
19 osteomalacia 30.7 FGF23 PTH VDR
20 iga glomerulonephritis 30.7 ACE ALB REN
21 pure red-cell aplasia 30.6 ALB EPO TF
22 renal dysplasia 30.6 ACE AGT GATA3 REN
23 analbuminemia 30.6 ALB CRP EPO TF TTR
24 nutritional deficiency disease 30.5 ALB CRP EPO LEP TF TTR
25 vesicoureteral reflux 1 30.5 AGT CRP REN
26 microvascular complications of diabetes 3 30.5 ACE AGT ALB INS
27 uremia 30.5 ALB B2M CRP EPO INS LEP
28 peripheral nervous system disease 30.5 ALB INS TTR
29 osteoporosis 30.5 ALB CRP FGF23 INS LEP PTH
30 atherosclerosis susceptibility 30.5 CRP INS TUG1
31 pyelonephritis 30.4 ACE ALB CRP
32 coronary stenosis 30.4 ACE ALB CRP
33 carotid artery disease 30.4 ACE CRP REN
34 pre-eclampsia 30.4 AGT LEP REN TUG1
35 rickets 30.3 FGF23 PTH VDR
36 malignant hypertension 30.3 ACE AGT REN
37 apnea, obstructive sleep 30.3 CRP INS LEP REN
38 membranous nephropathy 30.3 ACE ALB B2M TF
39 hypertension, essential 30.3 ACE AGT ALB COL4A5 CRP INS
40 liver cirrhosis 30.3 ALB LEP REN TF TTR
41 primary hyperparathyroidism 30.3 ALB FGF23 PTH VDR
42 microvascular complications of diabetes 5 30.2 ACE ALB INS
43 glucose intolerance 30.2 CRP INS LEP
44 hypercholesterolemia, familial 30.2 ACE AGT CRP INS
45 acute kidney failure 30.2 ALB B2M REN
46 cystic kidney disease 30.2 ALB B2M PKD1 PKD2
47 diabetic neuropathy 30.2 ACE EPO INS LEP
48 al amyloidosis 30.1 B2M TTR
49 hyperparathyroidism 30.1 EPO FGF23 PTH VDR
50 hypertensive encephalopathy 30.1 ACE EPO REN

Comorbidity relations with Chronic Kidney Failure via Phenotypic Disease Network (PDN): (show top 50) (show all 115)


Acquired Thrombocytopenia Active Peptic Ulcer Disease
Acute Cystitis Acute Kidney Failure
Acute Myocardial Infarction Acute Pancreatitis
Acute Proliferative Glomerulonephritis Acute Vascular Insufficiency of Intestine
Alcoholic Liver Cirrhosis Amyloidosis
Aortic Valve Disease 1 Bacteremia 2
Benign Essential Hypertension Benign Hypertensive Renal Disease
Benign Renovascular Hypertension Bladder Cancer
Bladder Neck Obstruction Bleeding Disorder, Platelet-Type, 11
Bronchitis Bronchopneumonia
Candidiasis Cardiac Arrest
Cardiogenic Shock Cerebral Atherosclerosis
Cerebrovascular Disease Chronic Intestinal Vascular Insufficiency
Chronic Myocardial Ischemia Chronic Rapidly Progressive Glomerulonephritis
Cystitis Decubitus Ulcer
Deficiency Anemia Dermatomycosis
Diabetic Polyneuropathy Disseminated Intravascular Coagulation
Duodenitis Encephalopathy
Esophageal Candidiasis Esophageal Disease
Esophagitis Familial Atrial Fibrillation
First-Degree Atrioventricular Block Generalized Atherosclerosis
Goodpasture Syndrome Gout
Heart Disease Hemolytic-Uremic Syndrome
Hepatic Encephalopathy Hepatorenal Syndrome
Hydronephrosis Hyperparathyroidism

Graphical network of the top 20 diseases related to Chronic Kidney Failure:



Diseases related to Chronic Kidney Failure

Symptoms & Phenotypes for Chronic Kidney Failure

UMLS symptoms related to Chronic Kidney Failure:


cloudy (hemodialysis) (peritoneal) dialysis effluent

MGI Mouse Phenotypes related to Chronic Kidney Failure:

46 (show all 17)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.49 ACE AGT B2M COL4A5 CRP EPO
2 homeostasis/metabolism MP:0005376 10.45 ACE AGT ALB B2M COL4A5 CRP
3 hematopoietic system MP:0005397 10.37 ACE B2M COL4A5 EPO FGF23 GATA3
4 growth/size/body region MP:0005378 10.36 ACE AGT B2M FGF23 GATA3 INS
5 immune system MP:0005387 10.36 ACE AGT B2M COL4A5 CRP EPO
6 endocrine/exocrine gland MP:0005379 10.3 ACE ALB B2M FGF23 GATA3 INS
7 cellular MP:0005384 10.29 ALB B2M EPO GATA3 INS LEP
8 digestive/alimentary MP:0005381 10.28 ALB B2M FGF23 GATA3 INS LEP
9 mortality/aging MP:0010768 10.25 ACE AGT ALB B2M COL4A5 EPO
10 adipose tissue MP:0005375 10.11 ACE AGT COL4A5 GATA3 INS LEP
11 integument MP:0010771 10.09 B2M EPO FGF23 GATA3 INS LEP
12 liver/biliary system MP:0005370 10.07 ACE AGT ALB B2M EPO INS
13 renal/urinary system MP:0005367 10 ACE AGT ALB COL4A5 FGF23 GATA3
14 limbs/digits/tail MP:0005371 9.95 EPO FGF23 LEP MKS1 PKD1 PTH
15 muscle MP:0005369 9.91 AGT ALB EPO GATA3 INS LEP
16 reproductive system MP:0005389 9.7 ACE AGT B2M FGF23 GATA3 INS
17 skeleton MP:0005390 9.28 EPO FGF23 GATA3 INS LEP MKS1

Drugs & Therapeutics for Chronic Kidney Failure

PubMedHealth treatment related to Chronic Kidney Failure: 63

The most suitable treatment for chronic kidney disease will depend on the cause and stage of the disease, as well as on the person’s life circumstances and preferences.If the kidneys are still working at a nearly normal level, treatment should aim to stop or slow down the progression of the disease. This is mainly done using medication to lower blood pressure levels and prevent cardiovascular disease. If you have diabetes, it's important to regulate your blood sugar levels.If complications such as anemia or bone metabolism disorders have already occurred, then more medications are used – such as medicines that contain iron or stimulate the production of blood, as well as medications called “phosphate binders.” If there is too much acid in your body, bicarbonates are used. In addition to the medication, the treatment will include a diet suited to the stage of the disease, drinking the right amounts of liquids and physical exercise.Dialysis or a kidney transplant are considered if the kidneys fail completely.In the vast majority of people with complete kidney failure, at least one of these options is possible. Some people make a conscious decision not to use either, accepting the fact that they could die soon afterwards. Palliative treatment may then be suitable for them – enabling a final phase of life that is as pleasant as possible.

Drugs for Chronic Kidney Failure (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 768)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Capsaicin Approved Phase 4 404-86-4 1548943
2
Simvastatin Approved Phase 4,Not Applicable 79902-63-9 54454
3
Ribavirin Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 36791-04-5 37542
4
Peginterferon alfa-2b Approved Phase 4,Phase 1,Not Applicable 99210-65-8, 215647-85-1
5
Nitric Oxide Approved Phase 4,Phase 1,Phase 2,Not Applicable 10102-43-9 145068
6
Digoxin Approved Phase 4 20830-75-5 30322 2724385
7
Acetylcysteine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 616-91-1 12035
8
Clopidogrel Approved Phase 4,Phase 3,Not Applicable 113665-84-2, 120202-66-6 60606
9
Ticlopidine Approved Phase 4,Phase 3 55142-85-3 5472
10
Ticagrelor Approved Phase 4,Phase 3,Phase 1,Phase 2 274693-27-5 9871419
11
Angiotensin II Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 11128-99-7, 68521-88-0, 4474-91-3 172198 65143
12
Losartan Approved Phase 4,Phase 3,Not Applicable 114798-26-4 3961
13
Olmesartan Approved, Investigational Phase 4,Phase 3,Not Applicable 144689-63-4, 144689-24-7 158781 130881
14
Candesartan cilexetil Approved Phase 4,Phase 3,Phase 2,Not Applicable 145040-37-5 2540
15
Telmisartan Approved, Investigational Phase 4,Phase 3,Not Applicable 144701-48-4 65999
16
Pentoxifylline Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 6493-05-6 4740
17
Valsartan Approved, Investigational Phase 4,Phase 3,Phase 2 137862-53-4 60846
18
Irbesartan Approved, Investigational Phase 4,Phase 3,Phase 2 138402-11-6 3749
19
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 3 2078-54-8 4943
20
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 3 113775-47-6 68602 5311068
21
Nadroparin Approved, Investigational Phase 4
22
Dalteparin Approved Phase 4,Phase 2,Phase 3,Not Applicable 9005-49-6
23
Heparin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 9005-49-6 772 46507594
24
Ursodeoxycholic acid Approved, Investigational Phase 4 128-13-2 31401
25
Furosemide Approved, Vet_approved Phase 4,Phase 3,Phase 1,Not Applicable 54-31-9 3440
26
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
27
Spironolactone Approved Phase 4,Phase 3,Phase 2,Not Applicable 52-01-7, 1952-01-7 5833
28
Chlorhexidine Approved, Vet_approved Phase 4,Not Applicable 55-56-1 2713 9552079
29
Mupirocin Approved, Investigational, Vet_approved Phase 4 12650-69-0 446596
30
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 94-09-7, 1994-09-7 2337
31
alemtuzumab Approved, Investigational Phase 4,Phase 1,Phase 2 216503-57-0
32 tannic acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
33
Tacrolimus Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 104987-11-3 445643 439492
34
Lidocaine Approved, Vet_approved Phase 4,Not Applicable 137-58-6 3676
35
Bupivacaine Approved, Investigational Phase 4,Phase 3,Not Applicable 2180-92-9, 38396-39-3 2474
36
Pregabalin Approved, Illicit, Investigational Phase 4 148553-50-8 5486971
37
Alendronate Approved Phase 4,Not Applicable 66376-36-1, 121268-17-5 2088
38
Hydrochlorothiazide Approved, Vet_approved Phase 4,Phase 3,Not Applicable 58-93-5 3639
39
Acarbose Approved, Investigational Phase 4 56180-94-0 441184
40
Pioglitazone Approved, Investigational Phase 4,Phase 2,Not Applicable 111025-46-8 4829
41
Ezetimibe Approved Phase 4 163222-33-1 150311
42
Fosinopril Approved Phase 4,Phase 3,Not Applicable 98048-97-6 55891
43
Darbepoetin alfa Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 11096-26-7, 209810-58-2
44
Amlodipine Approved Phase 4,Phase 3,Phase 2,Not Applicable 88150-42-9 2162
45
Sirolimus Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 53123-88-9 46835353 6436030 5284616
46
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 22916-47-8 4189
47
Everolimus Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 159351-69-6 6442177
48
Colchicine Approved Phase 4,Phase 2 64-86-8 6167 2833
49
Mycophenolic acid Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 24280-93-1 446541
50 Taurolidine Approved, Investigational Phase 4,Phase 3 19388-87-5

Interventional clinical trials:

(show top 50) (show all 2015)
# Name Status NCT ID Phase Drugs
1 Qutenza for Critical Ischaemia in End Stage Renal Failure Unknown status NCT01704339 Phase 4 QUTENZA
2 Simvastatin Effect on End Stage Renal Failure Patients Treated by Peritoneal Dialysis Unknown status NCT00291863 Phase 4 Simvastatin
3 Inspiratory Muscle Training in Patients With End Stage Renal Failure Unknown status NCT01347775 Phase 4
4 Effect of Sodium Rinsing Fluid on Blood Pressure and Interdialytic Weight Change in Hemodialysis Patients Unknown status NCT02590081 Phase 4 Dextrose 5%;normal saline
5 A Pilot Study to Treat Patients With Chronic Hepatitis C Virus (HCV) Genotype 1 and End-Stage Renal Disease (ESRD) Unknown status NCT01731301 Phase 4 Ribavirin;Peginterferon;Boceprevir
6 Far Infrared Therapy on AV Fistula Flow, Endothelial Function and Echocardiography in ESRD Patients Unknown status NCT01138254 Phase 4
7 Marinobufagenin as a Target for DIGIBIND in Hypertensive Patients With End-stage Renal Disease Unknown status NCT00852787 Phase 4 Digoxin immune fab;Placebo
8 Effect of Hydration With Sodium Bicarbonate for Long-Term Clinical Outcomes in Patients With Chronic Kidney Disease Undergoing an Emergent Coronary Procedure Unknown status NCT00716001 Phase 4 N-acetylcysteine
9 Platelet Resistance With Ticagrelor or Standard-Dose Clopidogrel Among CKD and ACS Patients Unknown status NCT02459288 Phase 4 Clopidogrel first;Ticagrelor first
10 NAC in Preventing CIN in CRF Patients Who Need Enhanced CT Scan in ED Unknown status NCT00501475 Phase 4 NAC Bicarbonate
11 Renoprotection by Pentoxifylline and Angiotensin Receptor Blocker in Chronic Kidney Disease (CKD) Unknown status NCT01377285 Phase 4 ARB;Pentoxifylline;Placebo (for Pentoxifylline)
12 Dexmedetomidine and Propofol As Sole Sedative Agent for Patients Undergoing Arteriovenous Fistula Surgery Unknown status NCT02447796 Phase 4 Propofol;Dexmedetomidine
13 Effect of Laparoscopic Sleeve Gastrectomy in the Morbidly Obese, Kidney Transplant Candidate Unknown status NCT01913392 Phase 4
14 Effects of On-Line Hemodiafiltration(HDF) on Vascular Health in Chronic Hemodialysis Patients Unknown status NCT00532597 Phase 4
15 A Study of Ferric Citrate to Improve Inflammation and Lipid Levels Unknown status NCT02661295 Phase 4 Ferric Citrate
16 LMWH Infusion as Anticoagulation for Home HD Unknown status NCT02957877 Phase 4 Nadroparin;Unfractionated heparin
17 Effect of Ursodeoxycholic Acid on Peritoneal Function in Patients on Peritoneal Dialysis Unknown status NCT02338635 Phase 4 Ursodeoxycholic Acid
18 The Use of Furosemide in Patients on Dialysis Unknown status NCT01815892 Phase 4 Withdrawal of furosemide;furosemide administration
19 Body Composition Monitor in Hemodialysis Patients Unknown status NCT01103167 Phase 4
20 Effect of Different Hemodialysis Modality on Adiponectin,Vascular Function and Clinical Prognosis Unknown status NCT00155363 Phase 4
21 Effects of an Exercise Program in Patients With Hypertensive Chronic Kidney Disease Unknown status NCT01155128 Phase 4
22 Opioids in Chronic Kidney Disease Patients Undergoing Hemodialysis Unknown status NCT02452437 Phase 4 Oxycodone
23 Hypervolemia in ESRD Patients in Zonguldak (Prospective Study) Unknown status NCT01468363 Phase 4
24 Cardiovascular Protective Effect of Spironolactone in Hemodialysis Unknown status NCT00277693 Phase 4 Spironolactone (drug)
25 The Canadian Prevention of Renal and Cardiovascular Endpoints Trial Unknown status NCT00231803 Phase 4
26 Intravenous Paricalcitol in Chronic Hemodialysis Patients Unknown status NCT03023748 Phase 4 Intravenous Paricalcitol
27 Chlorhexidine Gluconate Versus Mupirocin Ointment in the Prevention of Peritoneal Dialysis-Related Infection Unknown status NCT02547103 Phase 4
28 Anti-Oxidant Effect on Peritoneal Membrane in Peritoneal Dialysis (PD) Patients Unknown status NCT01111422 Phase 4 N-acetylcysteine
29 Standard Versus Prolonged-release Tacrolimus Monotherapy After Alemtuzumab Induction in Kidney Transplantation Unknown status NCT00807144 Phase 4 Tacrolimus (Kidney transplant maintenance immunosuppression);Kidney transplant maintenance immunosuppression
30 RAAS Inhibitor Drugs in Dialysis Patients Unknown status NCT01635387 Phase 4 aliskiren
31 More Frequent Dialysis (>3 Treatments Per Week) Unknown status NCT00575497 Phase 4
32 2% Lidocaine Plus 0.5% Bupivacaine Versus 0.5% Bupivacaine in Brachial Block for Creation of Arteriovenous (AV) Fistula Unknown status NCT00993746 Phase 4 Bupivacaine plus lidocaine;Bupivacaine 30 ml
33 The Effect and Safety of the Seasonal Trivalent Influenza Vaccine in Chronic Kidney Disease Patients Not on Dialysis Unknown status NCT02105519 Phase 4
34 Far Infrared Therapy on Peripheral Artery Disease in Hemodialysis Patients Unknown status NCT01095549 Phase 4
35 Efficacy of Pregabalin in the Management of Chronic Uremic Pruritus Unknown status NCT01073501 Phase 4 Pregabalin;Placebo
36 Clinical Impact of Bacteriuria on Chronic Inflammation in Asymptomatic Hemodialysis Patients Unknown status NCT01570556 Phase 4
37 Alendronate for Vascular Calcification in Peritoneal Dialysis Patients? Unknown status NCT00299572 Phase 4 alendronate (Fosamax)
38 Clinical Trial Technology Development for the Validation of Surrogate Prognostic Markers in Patients With Diabetic Nephropathy Unknown status NCT01673204 Phase 4 Calcitriol;Placebo
39 Effect of Intravenous Acetadote on Incidence of Contrast Induced Nephropathy Unknown status NCT00939913 Phase 4 intravenous NAC;Placebo
40 Clinical Trial to Compare Effectiveness of Diuretics in Hemodialysis Patients With Residual Renal Function Unknown status NCT01977430 Phase 4 Hydrochlorothiazide and furosemide
41 Thiazolidinedione (TZD) on the Diabetic Retinopathy and Nephropathy Unknown status NCT01175486 Phase 4 Actos (Pioglitazone);Acarbose
42 The Effects of Acetylcysteine on Alleviating Damage of Oxidative Stress in Hemodialysis Patients Unknown status NCT00247507 Phase 4 acetylcysteine
43 Ezetimibe/Simvastatin Combination in Proteinuric Nephropathy Unknown status NCT00861731 Phase 4 simvastatin;EZE/simvastatin;EZE/simvastatin
44 Benidipine and Hydrochlorothiazide in Fosinopril Treated Chronic Kidney Disease Patients With Hypertension Unknown status NCT02646397 Phase 4 Fosinopril;Benidipine;Hydrochlorothiazide
45 Revascularization of Renal Artery Stenosis Versus Medical Therapy for the Treatment of Ischemic Nephropathy Unknown status NCT01023373 Phase 4 Medical treatment
46 Study Response of 13-valent Conjugate Pneumococcal Vaccine in Patients With End Stage Renal Disease Completed NCT01974817 Phase 4
47 Parathyroidectomy in Endstage Renal Disease Completed NCT00745719 Phase 4
48 Evaluating Aranesp® for the Treatment of Anemia in African-American Subjects With Chronic Renal Failure (CRF) Receiving Hemodialysis Completed NCT00111995 Phase 4 Aranesp®
49 Interferon Treatment for Patients With Chronic Hepatitis C and End Stage Renal Disease Completed NCT00172809 Phase 4 Peginterferon alfa-2a;Interferon alfa-2a
50 Ombitasvir/ Paritaprevir / Ritonavir Plus Ribavirin in Management HCV and End-stage Kidney Disease Completed NCT03499639 Phase 4 Ombitasvir / Paritaprevir / Ritonavir /Ribavirin Oral Tablet

Search NIH Clinical Center for Chronic Kidney Failure

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Chronic Kidney Failure cell therapies at LifeMap Discovery.

Cochrane evidence based reviews: kidney failure, chronic

Genetic Tests for Chronic Kidney Failure

Genetic tests related to Chronic Kidney Failure:

# Genetic test Affiliating Genes
1 Chronic Kidney Disease 29

Anatomical Context for Chronic Kidney Failure

MalaCards organs/tissues related to Chronic Kidney Failure:

41
Kidney, Bone, Heart, Endothelial, Liver, Testes, Neutrophil
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Chronic Kidney Failure:
# Tissue Anatomical CompartmentCell Relevance
1 Bone Bone Marrow Bone Marrow Stromal Cells Potential therapeutic candidate
2 Adipose Subcutaneous White Adipose Mesenchymal Stem Cells Potential therapeutic candidate
3 Kidney Proximal Tubule Proximal Tubule Cells Affected by disease, potential therapeutic candidate
4 Adipose Subcutaneous White Adipose Stromal Cells Potential therapeutic candidate

Publications for Chronic Kidney Failure

Articles related to Chronic Kidney Failure:

(show top 50) (show all 3537)
# Title Authors Year
1
Cinacalcet as rescue therapy for refractory hyperparathyroidism in young children with advanced chronic kidney disease. ( 30203374 )
2019
2
Analytical validity of a genotyping assay for use with personalized antihypertensive and chronic kidney disease therapy. ( 30489456 )
2019
3
Estimated Glomerular Filtration Rates Show Minor but Significant Differences Between the Single and Subgroup Creatinine-Based Chronic Kidney Disease Epidemiology Collaboration Equations. ( 30430784 )
2019
4
Genes and environment in chronic kidney disease hotspots. ( 30451737 )
2019
5
Chronic Kidney Disease and Dietary Measures to Improve Outcomes. ( 30454747 )
2019
6
Growth hormone and chronic kidney disease. ( 30394899 )
2019
7
Methylglyoxal stress, the glyoxalase system, and diabetic chronic kidney disease. ( 30320620 )
2019
8
Sex hormones and their influence on chronic kidney disease. ( 30320621 )
2019
9
Mild to moderate chronic kidney disease and functional disability in community-dwelling older adults. The Cardiovascular risk profile in Renal patients of the Italian Health Examination Survey (CARHES) study. ( 30343147 )
2019
10
Racial-ethnic differences in chronic kidney disease-mineral bone disorder in youth on dialysis. ( 30267239 )
2019
11
Obstructive sleep apnea in non-dialyzed chronic kidney disease patients: Association with body adiposity and sarcopenia. ( 30219685 )
2019
12
DDT and its metabolites could contribute to the aetiology of chronic kidney disease of unknown aetiology (CKDu) and more studies are a priority. ( 30227991 )
2019
13
There is no evidence that organochlorine pesticides, such as DDT, cause chronic kidney disease of unknown etiology. ( 30243793 )
2019
14
An open-label, single-dose study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of cinacalcet in pediatric subjects aged 28 days to < 6 years with chronic kidney disease receiving dialysis. ( 30141180 )
2019
15
Comment: Safety and Efficacy of Apixaban Versus Warfarin in Patients With Advanced Chronic Kidney Disease. ( 30187763 )
2019
16
Does a multimethod approach improve identification of medication nonadherence in adolescents with chronic kidney disease? ( 30116892 )
2019
17
Effects of additional vasodilatory or nonvasodilatory treatment on renal function, vascular resistance and oxygenation in chronic kidney disease: a randomized clinical trial. ( 29995697 )
2019
18
Hepcidin and proinflammatory markers inA children with chronic kidney disease: AA case-control studya8c. ( 29451472 )
2018
19
Cinacalcet versus Placebo for secondary hyperparathyroidism in chronic kidney disease patients: a meta-analysis of randomized controlled trials and trial sequential analysis. ( 29449603 )
2018
20
Does Chronic Kidney Disease-Induced Cognitive Impairment Affect Driving Safety? ( 29977582 )
2018
21
Treatment of Hyperuricemia in Chronic Kidney Disease. ( 29393124 )
2018
22
Hyperuricemia and Progression of Chronic Kidney Disease: Role of Phenotype Transition of Renal Tubular and Endothelial Cells. ( 29393109 )
2018
23
Chronic kidney disease and acquired mitochondrial myopathy. ( 29266014 )
2018
24
Chronic kidney disease mortality trends in selected Central America countries, 1997-2013: clues to an epidemic of chronic interstitial nephritis of agricultural communities. ( 29437864 )
2018
25
Differential Clinical Outcomes Between Angiographic Complete Versus Incomplete Coronary Revascularization, According to the Presence of Chronic Kidney Disease in the Drug-Eluting Stent Era. ( 29449272 )
2018
26
Anti-Transforming Growth Factor I^ IgG Elicits a Dual Effect on Calcium Oxalate Crystallization and Progressive Nephrocalcinosis-Related Chronic Kidney Disease. ( 29651290 )
2018
27
Clinicopathological predictors for progression of chronic kidney disease in nephrosclerosis: a biopsy-based cohort study. ( 29788462 )
2018
28
Inhaling Difluoroethane Computer Cleaner Resulting in Acute Kidney Injury and Chronic Kidney Disease. ( 29977633 )
2018
29
A case report of remission of refractory membranous nephropathy progressing to stage 4 chronic kidney disease using low-dose rituximab: A long-term follow-up. ( 29924035 )
2018
30
Cost-Effectiveness of First-Line Sevelamer and Lanthanum versus Calcium-Based Binders for Hyperphosphatemia of Chronic Kidney Disease. ( 29566839 )
2018
31
Prediction of chronic kidney disease after acute kidney injury in ICU patients: study protocol for the PREDICT multicenter prospective observational study. ( 29980878 )
2018
32
Diagnosis and Treatment of Metabolic Acidosis in Patients with Chronic Kidney Disease - Position Statement of the Working Group of the Polish Society of Nephrology. ( 29895022 )
2018
33
Hepatitis C virus infection in chronic kidney disease: paradigm shift in management. ( 29961309 )
2018
34
Phosphate stimulates myotube atrophy through autophagy activation: evidence of hyperphosphatemia contributing to skeletal muscle wasting in chronic kidney disease. ( 29486729 )
2018
35
Intradialytic neuromuscular electrical stimulation reduces DNA damage in chronic kidney failure patients: a randomized controlled trial. ( 29529880 )
2018
36
Effector I^I' T cells in human renal fibrosis and chronic kidney disease. ( 29897565 )
2018
37
Using Machine Learning Algorithms to Predict Risk for Development of Calciphylaxis in Patients with Chronic Kidney Disease. ( 29888059 )
2018
38
No difference in renal injury and fibrosis between wild-type and NOD1/NOD2 double knockout mice with chronic kidney disease induced by ureteral obstruction. ( 29609537 )
2018
39
Prevalence of Chronic Kidney Disease in Iranian General Population: A Meta-Analysis and Systematic Review. ( 29974630 )
2018
40
Evaluation of Serum Symmetric Dimethylarginine Concentration as a Marker for Masked Chronic Kidney Disease in Cats With Hyperthyroidism. ( 29377360 )
2018
41
Proton Pump Inhibitors and Chronic Kidney Disease: Is It Related to the Accumulation of Toxic Breakdown Products Spontaneously Formed in the Enteric-Protected Tablets? ( 29452088 )
2018
42
A novel UMOD gene mutation associated with chronic kidney failure at a young age. ( 29424336 )
2018
43
Baseline Characteristics of the Autosomal Dominant Polycystic Kidney Disease Subcohort of the KoreaN Cohort Study for Outcomes in Patients With Chronic Kidney Disease (KNOW-CKD). ( 29797773 )
2018
44
Monocyte count modifies the association between chronic kidney disease and risk ofA deatha8c. ( 29974856 )
2018
45
Loop diuretics are associated with greater risk of sarcopenia in patients with non-dialysis-dependent chronic kidney disease. ( 29447254 )
2018
46
Initial surgical results of 500 Parathyroidectomies for Hyperparathyroidism related to chronic kidney disease - mineral and bone disorder. ( 29944161 )
2018
47
Leptin and ghrelin in chronic kidney disease: their associations with protein-energy wasting. ( 29980850 )
2018
48
Risk Factors for Carotid Artery Disease and Chronic Kidney Disease: Same or Unique? ( 29405657 )
2018
49
Apolipoprotein M in patients with chronic kidney disease. ( 29980057 )
2018
50
Malnutrition in Chronic Kidney Disease. ( 29974043 )
2018

Variations for Chronic Kidney Failure

ClinVar genetic disease variations for Chronic Kidney Failure:

6 (show all 16)
# Gene Variation T