MCID: CHR089
MIFTS: 73

Chronic Kidney Failure

Categories: Blood diseases, Bone diseases, Genetic diseases, Nephrological diseases

Aliases & Classifications for Chronic Kidney Failure

MalaCards integrated aliases for Chronic Kidney Failure:

Name: Chronic Kidney Failure 39 12
Chronic Kidney Disease 12 30 6 44 3 15 64 17
Kidney Failure, Chronic 45 74
Chronic Renal Disease 12 15
Ckd 12 3
Chronic Renal Failure Syndrome 12
Chronic Kidney Disease Stage 5 74
Renal Failure - Chronic 12
Chronic Kidney Diseases 74
Chronic Renal Failure 77
Renal Failure Chronic 56
Crf 12

Classifications:



External Ids:

Disease Ontology 12 DOID:784
ICD9CM 36 585.6
MeSH 45 D007676
NCIt 51 C9438
SNOMED-CT 69 46177005 90688005
ICD10 34 N18 N18.5 N18.9

Summaries for Chronic Kidney Failure

MedlinePlus : 44 You have two kidneys, each about the size of your fist. Their main job is to filter your blood. They remove wastes and extra water, which become urine. They also keep the body's chemicals balanced, help control blood pressure, and make hormones. Chronic kidney disease (CKD) means that your kidneys are damaged and can't filter blood as they should. This damage can cause wastes to build up in your body. It can also cause other problems that can harm your health. Diabetes and high blood pressure are the most common causes of CKD. The kidney damage occurs slowly over many years. Many people don't have any symptoms until their kidney disease is very advanced. Blood and urine tests are the only way to know if you have kidney disease. Treatments cannot cure kidney disease, but they may slow kidney disease. They include medicines to lower blood pressure, control blood sugar, and lower cholesterol. CKD may still get worse over time. Sometimes it can lead to kidney failure. If your kidneys fail, you will need dialysis or a kidney transplantation. You can take steps to keep your kidneys healthier longer: Choose foods with less salt (sodium) Control your blood pressure; your health care provider can tell you what your blood pressure should be Keep your blood sugar in the target range, if you have diabetes Limit the amount of alcohol you drink Choose foods that are healthy for your heart: fruits, vegetables, whole grains, and low-fat dairy foods Lose weight if you are overweight Be physically active Don't smoke NIH: National Institute of Diabetes and Digestive and Kidney Diseases

MalaCards based summary : Chronic Kidney Failure, also known as chronic kidney disease, is related to end stage renal failure and calciphylaxis, and has symptoms including cloudy (hemodialysis) (peritoneal) dialysis effluent An important gene associated with Chronic Kidney Failure is COL4A5 (Collagen Type IV Alpha 5 Chain), and among its related pathways/superpathways are Adipogenesis and Renin secretion. The drugs Capsaicin and Simvastatin have been mentioned in the context of this disorder. Affiliated tissues include Bone and Adipose, and related phenotypes are cardiovascular system and homeostasis/metabolism

PubMed Health : 64 About chronic kidney disease: Our kidneys are vital organs that clean our blood and affect many different bodily functions. Various medical conditions can cause the kidneys to stop working properly for a short time – for example, if blood isn’t pumped around the body properly or if an enlarged prostate or kidney stones make urine build up in the kidneys.But if the kidneys still aren’t working at full capacity more than three months later or are permanently damaged, then the problem is considered to be chronic kidney disease. The most common causes in adults are diabetes and high blood pressure.Older people are especially prone to developing chronic kidney disease. It often goes unnoticed for a long time because poorly functioning kidneys don’t cause any problems at first.Treatment mostly aims to stop the kidney disease from getting worse, or at least delay the process. It is also important to treat complications such as anemia, acidosis or changes in bone metabolism. If the kidneys fail completely, dialysis or a kidney transplant can prolong the person’s life.

Wikipedia : 77 Chronic kidney disease (CKD) is a type of kidney disease in which there is gradual loss of kidney... more...

Related Diseases for Chronic Kidney Failure

Diseases in the Kidney Disease family:

Acute Kidney Failure Chronic Kidney Failure
Renal Infectious Disease Ren-Related Kidney Disease

Diseases related to Chronic Kidney Failure via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 851)
# Related Disease Score Top Affiliating Genes
1 end stage renal failure 33.5 ACE AGT ALB COL4A5 CRP EPO
2 calciphylaxis 32.8 ALB EPO FGF23 PTH VDR
3 hypoparathyroidism 32.2 FGF23 GATA3 PTH
4 hyperphosphatemia 31.6 FGF23 PTH VDR
5 arteries, anomalies of 31.5 ACE AGT ALB CRP INS LEP
6 diabetes mellitus, noninsulin-dependent 31.5 ACE AGT ALB CRP INS LEP
7 bone disease 31.5 B2M FGF23 PTH VDR
8 liver disease 31.5 ALB INS LEP PKD1 PKD2
9 myocardial infarction 31.4 ACE AGT ALB CRP INS REN
10 sleep apnea 31.4 ACE CRP INS LEP REN
11 peripheral vascular disease 31.4 ACE ALB CRP
12 osteomalacia 31.4 FGF23 PTH VDR
13 vascular disease 31.3 ACE ALB CRP INS REN
14 polycystic kidney disease 31.3 ACE PKD1 PKD2 REN
15 nephrolithiasis 31.3 FGF23 INS PTH VDR
16 iron deficiency anemia 31.2 CRP EPO FGF23
17 microvascular complications of diabetes 3 31.2 ACE AGT ALB INS
18 hypertension, essential 31.2 ACE AGT ALB COL4A5 INS LEP
19 obstructive nephropathy 31.1 ACE AGT ALB REN
20 autosomal dominant polycystic kidney disease 31.1 ACE AGT ALB FGF23 PKD1 PKD2
21 atherosclerosis susceptibility 31.1 CRP INS TUG1
22 iga glomerulonephritis 31.1 ACE ALB REN
23 microvascular complications of diabetes 5 31.0 ACE ALB INS
24 liver cirrhosis 31.0 ALB LEP REN TTR
25 renal dysplasia 30.9 ACE AGT GATA3 REN
26 pre-eclampsia 30.9 AGT LEP REN TUG1
27 uremia 30.8 ALB B2M CRP EPO INS LEP
28 peripheral nervous system disease 30.8 ALB INS TTR
29 coronary stenosis 30.7 ACE ALB CRP
30 carotid artery disease 30.7 ACE CRP REN
31 urinary tract obstruction 30.7 ALB B2M REN
32 malignant hypertension 30.7 ACE AGT REN
33 pure autonomic failure 30.7 ACE EPO REN TTR
34 apnea, obstructive sleep 30.7 CRP INS LEP REN
35 rickets 30.6 FGF23 PTH VDR
36 primary hyperparathyroidism 30.6 ALB FGF23 PTH VDR
37 glucose intolerance 30.6 CRP INS LEP
38 membranous nephropathy 30.6 ACE ALB B2M
39 hypercholesterolemia, familial 30.5 ACE AGT CRP INS
40 acute kidney failure 30.5 ALB B2M REN
41 hypertensive encephalopathy 30.5 ACE EPO REN
42 diabetic neuropathy 30.5 ACE EPO INS LEP
43 uremic neuropathy 30.5 B2M EPO PTH
44 hyperparathyroidism 30.5 EPO FGF23 PTH VDR
45 pyelonephritis 30.5 ACE ALB CRP
46 renal osteodystrophy 30.5 FGF23 PTH VDR
47 lipid metabolism disorder 30.5 ACE CRP INS LEP
48 hypoaldosteronism 30.5 ACE REN
49 protein-energy malnutrition 30.5 ALB LEP TTR
50 multicystic dysplastic kidney 30.5 PKD1 PKD2 REN

Comorbidity relations with Chronic Kidney Failure via Phenotypic Disease Network (PDN): (show top 50) (show all 114)


Acquired Thrombocytopenia Active Peptic Ulcer Disease
Acute Cystitis Acute Kidney Failure
Acute Myocardial Infarction Acute Pancreatitis
Acute Proliferative Glomerulonephritis Acute Vascular Insufficiency of Intestine
Alcoholic Liver Cirrhosis Amyloidosis
Aortic Valve Disease 1 Bacteremia 2
Benign Essential Hypertension Benign Hypertensive Renal Disease
Benign Renovascular Hypertension Bladder Cancer
Bladder Neck Obstruction Bleeding Disorder, Platelet-Type, 11
Bronchitis Bronchopneumonia
Candidiasis Cardiac Arrest
Cardiogenic Shock Cerebral Atherosclerosis
Cerebrovascular Disease Chronic Intestinal Vascular Insufficiency
Chronic Myocardial Ischemia Chronic Rapidly Progressive Glomerulonephritis
Cystitis Decubitus Ulcer
Deficiency Anemia Dermatomycosis
Diabetic Polyneuropathy Disseminated Intravascular Coagulation
Duodenitis Encephalopathy
Esophageal Candidiasis Esophageal Disease
Esophagitis Familial Atrial Fibrillation
First-Degree Atrioventricular Block Generalized Atherosclerosis
Goodpasture Syndrome Gout
Heart Disease Hemolytic-Uremic Syndrome
Hepatic Encephalopathy Hepatorenal Syndrome
Hydronephrosis Hyperparathyroidism

Graphical network of the top 20 diseases related to Chronic Kidney Failure:



Diseases related to Chronic Kidney Failure

Symptoms & Phenotypes for Chronic Kidney Failure

UMLS symptoms related to Chronic Kidney Failure:


cloudy (hemodialysis) (peritoneal) dialysis effluent

MGI Mouse Phenotypes related to Chronic Kidney Failure:

47 (show all 17)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.49 ACE AGT B2M COL4A5 CRP EPO
2 homeostasis/metabolism MP:0005376 10.43 ACE AGT ALB B2M COL4A5 CRP
3 immune system MP:0005387 10.36 ACE AGT B2M COL4A5 CRP EPO
4 endocrine/exocrine gland MP:0005379 10.34 ACE ALB B2M FGF23 GATA3 INS
5 hematopoietic system MP:0005397 10.34 ACE B2M COL4A5 EPO FGF23 GATA3
6 cellular MP:0005384 10.33 ALB B2M EPO GATA3 INS LEP
7 growth/size/body region MP:0005378 10.32 ACE AGT B2M FGF23 GATA3 INS
8 digestive/alimentary MP:0005381 10.28 ALB B2M FGF23 GATA3 INS LEP
9 mortality/aging MP:0010768 10.22 ACE AGT ALB B2M COL4A5 EPO
10 adipose tissue MP:0005375 10.11 ACE AGT COL4A5 GATA3 INS LEP
11 integument MP:0010771 10.09 B2M EPO FGF23 GATA3 INS LEP
12 liver/biliary system MP:0005370 10.07 ACE AGT ALB B2M EPO INS
13 renal/urinary system MP:0005367 10.03 ACE AGT ALB COL4A5 FGF23 GATA3
14 limbs/digits/tail MP:0005371 9.95 EPO FGF23 LEP MKS1 PKD1 PTH
15 muscle MP:0005369 9.91 AGT ALB EPO GATA3 INS LEP
16 reproductive system MP:0005389 9.73 ACE AGT B2M FGF23 GATA3 INS
17 skeleton MP:0005390 9.28 EPO FGF23 GATA3 INS LEP MKS1

Drugs & Therapeutics for Chronic Kidney Failure

PubMedHealth treatment related to Chronic Kidney Failure: 64

The most suitable treatment for chronic kidney disease will depend on the cause and stage of the disease, as well as on the person’s life circumstances and preferences.If the kidneys are still working at a nearly normal level, treatment should aim to stop or slow down the progression of the disease. This is mainly done using medication to lower blood pressure levels and prevent cardiovascular disease. If you have diabetes, it's important to regulate your blood sugar levels.If complications such as anemia or bone metabolism disorders have already occurred, then more medications are used – such as medicines that contain iron or stimulate the production of blood, as well as medications called “phosphate binders.” If there is too much acid in your body, bicarbonates are used. In addition to the medication, the treatment will include a diet suited to the stage of the disease, drinking the right amounts of liquids and physical exercise.Dialysis or a kidney transplant are considered if the kidneys fail completely.In the vast majority of people with complete kidney failure, at least one of these options is possible. Some people make a conscious decision not to use either, accepting the fact that they could die soon afterwards. Palliative treatment may then be suitable for them – enabling a final phase of life that is as pleasant as possible.

Drugs for Chronic Kidney Failure (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 1032)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Capsaicin Approved Phase 4 404-86-4 1548943
2
Simvastatin Approved Phase 4,Phase 3,Not Applicable 79902-63-9 54454
3
Ribavirin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 36791-04-5 37542
4
Peginterferon alfa-2b Approved Phase 4,Phase 1,Not Applicable 215647-85-1, 99210-65-8
5
Nitric Oxide Approved Phase 4,Phase 1,Phase 2,Not Applicable 10102-43-9 145068
6
Digoxin Approved Phase 4 20830-75-5 2724385 30322
7
Acetylcysteine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 616-91-1 12035
8
Clopidogrel Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 120202-66-6, 113665-84-2 60606
9
Ticagrelor Approved Phase 4,Phase 3,Phase 1,Phase 2 274693-27-5 9871419
10
Angiotensin II Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 11128-99-7, 68521-88-0, 4474-91-3 172198
11
Losartan Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 114798-26-4 3961
12
Olmesartan Approved, Investigational Phase 4,Phase 3,Not Applicable 144689-24-7, 144689-63-4 158781 130881
13
Candesartan cilexetil Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 145040-37-5 2540
14
Telmisartan Approved, Investigational Phase 4,Phase 3,Not Applicable 144701-48-4 65999
15
Pentoxifylline Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 6493-05-6 4740
16
Valsartan Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 137862-53-4 60846
17
Irbesartan Approved, Investigational Phase 4,Phase 3,Phase 2 138402-11-6 3749
18
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable 2078-54-8 4943
19
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 3,Not Applicable 113775-47-6 5311068 68602
20
Sodium Citrate Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 68-04-2
21
Nadroparin Approved, Investigational Phase 4
22
Dalteparin Approved Phase 4,Phase 2,Phase 3,Not Applicable 9005-49-6
23
Heparin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 9005-49-6 46507594 772
24
Ursodeoxycholic acid Approved, Investigational Phase 4 128-13-2 31401
25
Furosemide Approved, Vet_approved Phase 4,Phase 3,Phase 1,Not Applicable 54-31-9 3440
26
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
27
Spironolactone Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 1952-01-7, 52-01-7 5833
28
Tacrolimus Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 104987-11-3 6473866 445643 439492
29
tannic acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 1401-55-4
30
alemtuzumab Approved, Investigational Phase 4,Phase 1,Phase 2,Not Applicable 216503-57-0
31
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 1994-09-7, 94-09-7 2337
32
Lidocaine Approved, Vet_approved Phase 4,Not Applicable 137-58-6 3676
33
Bupivacaine Approved, Investigational Phase 4,Phase 3,Not Applicable 38396-39-3, 2180-92-9 2474
34
Pregabalin Approved, Illicit, Investigational Phase 4 148553-50-8 5486971
35
Alendronate Approved Phase 4,Not Applicable 66376-36-1, 121268-17-5 2088
36
Hydrochlorothiazide Approved, Vet_approved Phase 4,Phase 3,Phase 1,Not Applicable,Early Phase 1 58-93-5 3639
37
Acarbose Approved, Investigational Phase 4 56180-94-0 441184
38
Pioglitazone Approved, Investigational Phase 4,Phase 2,Not Applicable 111025-46-8 4829
39
Ezetimibe Approved Phase 4,Phase 3 163222-33-1 150311
40
Fosinopril Approved Phase 4,Phase 3,Not Applicable 98048-97-6 55891
41
Perindopril Approved Phase 4 107133-36-8, 82834-16-0 107807
42
Denosumab Approved Phase 4,Phase 3,Phase 1 615258-40-7
43
Parathyroid hormone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 9002-64-6
44
Iron Approved, Experimental Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 7439-89-6, 15438-31-0 27284 23925
45
Phylloquinone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 84-80-0
46 Menaquinone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1182-68-9
47
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-78-2 2244
48
carbamide peroxide Approved Phase 4,Phase 3,Phase 2,Not Applicable 124-43-6
49
Enalaprilat Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 76420-72-9 6917719
50
Enalapril Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 75847-73-3 40466924 5362032

Interventional clinical trials:

(show top 50) (show all 3930)
# Name Status NCT ID Phase Drugs
1 Qutenza for Critical Ischaemia in End Stage Renal Failure Unknown status NCT01704339 Phase 4 QUTENZA
2 Simvastatin Effect on End Stage Renal Failure Patients Treated by Peritoneal Dialysis Unknown status NCT00291863 Phase 4 Simvastatin
3 Inspiratory Muscle Training in Patients With End Stage Renal Failure Unknown status NCT01347775 Phase 4
4 Effect of Sodium Rinsing Fluid on Blood Pressure and Interdialytic Weight Change in Hemodialysis Patients Unknown status NCT02590081 Phase 4 Dextrose 5%;normal saline
5 A Pilot Study to Treat Patients With Chronic Hepatitis C Virus (HCV) Genotype 1 and End-Stage Renal Disease (ESRD) Unknown status NCT01731301 Phase 4 Ribavirin;Peginterferon;Boceprevir
6 Far Infrared Therapy on AV Fistula Flow, Endothelial Function and Echocardiography in ESRD Patients Unknown status NCT01138254 Phase 4
7 Marinobufagenin as a Target for DIGIBIND in Hypertensive Patients With End-stage Renal Disease Unknown status NCT00852787 Phase 4 Digoxin immune fab;Placebo
8 Effect of Hydration With Sodium Bicarbonate for Long-Term Clinical Outcomes in Patients With Chronic Kidney Disease Undergoing an Emergent Coronary Procedure Unknown status NCT00716001 Phase 4 N-acetylcysteine
9 Platelet Resistance With Ticagrelor or Standard-Dose Clopidogrel Among CKD and ACS Patients Unknown status NCT02459288 Phase 4 Clopidogrel first;Ticagrelor first
10 NAC in Preventing CIN in CRF Patients Who Need Enhanced CT Scan in ED Unknown status NCT00501475 Phase 4 NAC Bicarbonate
11 Renoprotection by Pentoxifylline and Angiotensin Receptor Blocker in Chronic Kidney Disease (CKD) Unknown status NCT01377285 Phase 4 ARB;Pentoxifylline;Placebo (for Pentoxifylline)
12 Dexmedetomidine and Propofol As Sole Sedative Agent for Patients Undergoing Arteriovenous Fistula Surgery Unknown status NCT02447796 Phase 4 Propofol;Dexmedetomidine
13 Effect of Laparoscopic Sleeve Gastrectomy in the Morbidly Obese, Kidney Transplant Candidate Unknown status NCT01913392 Phase 4
14 Effects of On-Line Hemodiafiltration(HDF) on Vascular Health in Chronic Hemodialysis Patients Unknown status NCT00532597 Phase 4
15 A Study of Ferric Citrate to Improve Inflammation and Lipid Levels Unknown status NCT02661295 Phase 4 Ferric Citrate
16 LMWH Infusion as Anticoagulation for Home HD Unknown status NCT02957877 Phase 4 Nadroparin;Unfractionated heparin
17 Effect of Ursodeoxycholic Acid on Peritoneal Function in Patients on Peritoneal Dialysis Unknown status NCT02338635 Phase 4 Ursodeoxycholic Acid
18 The Use of Furosemide in Patients on Dialysis Unknown status NCT01815892 Phase 4 Withdrawal of furosemide;furosemide administration
19 Body Composition Monitor in Hemodialysis Patients Unknown status NCT01103167 Phase 4
20 Effect of Different Hemodialysis Modality on Adiponectin,Vascular Function and Clinical Prognosis Unknown status NCT00155363 Phase 4
21 Effects of an Exercise Program in Patients With Hypertensive Chronic Kidney Disease Unknown status NCT01155128 Phase 4
22 Opioids in Chronic Kidney Disease Patients Undergoing Hemodialysis Unknown status NCT02452437 Phase 4 Oxycodone
23 Hypervolemia in ESRD Patients in Zonguldak (Prospective Study) Unknown status NCT01468363 Phase 4
24 Cardiovascular Protective Effect of Spironolactone in Hemodialysis Unknown status NCT00277693 Phase 4 Spironolactone (drug)
25 The Canadian Prevention of Renal and Cardiovascular Endpoints Trial Unknown status NCT00231803 Phase 4
26 Intravenous Paricalcitol in Chronic Hemodialysis Patients Unknown status NCT03023748 Phase 4 Intravenous Paricalcitol
27 Anti-Oxidant Effect on Peritoneal Membrane in Peritoneal Dialysis (PD) Patients Unknown status NCT01111422 Phase 4 N-acetylcysteine
28 Standard Versus Prolonged-release Tacrolimus Monotherapy After Alemtuzumab Induction in Kidney Transplantation Unknown status NCT00807144 Phase 4 Tacrolimus (Kidney transplant maintenance immunosuppression);Kidney transplant maintenance immunosuppression
29 RAAS Inhibitor Drugs in Dialysis Patients Unknown status NCT01635387 Phase 4 aliskiren
30 2% Lidocaine Plus 0.5% Bupivacaine Versus 0.5% Bupivacaine in Brachial Block for Creation of Arteriovenous (AV) Fistula Unknown status NCT00993746 Phase 4 Bupivacaine plus lidocaine;Bupivacaine 30 ml
31 Safety and Effect of Elbasvir/Grazoprevir Combination Therapy in Hemodialysis Patients With Chronic Hepatitis C Unknown status NCT03022006 Phase 4 elbasvir, grazoprevir
32 The Effect and Safety of the Seasonal Trivalent Influenza Vaccine in Chronic Kidney Disease Patients Not on Dialysis Unknown status NCT02105519 Phase 4
33 Far Infrared Therapy on Peripheral Artery Disease in Hemodialysis Patients Unknown status NCT01095549 Phase 4
34 Efficacy of Pregabalin in the Management of Chronic Uremic Pruritus Unknown status NCT01073501 Phase 4 Pregabalin;Placebo
35 Clinical Impact of Bacteriuria on Chronic Inflammation in Asymptomatic Hemodialysis Patients Unknown status NCT01570556 Phase 4
36 Alendronate for Vascular Calcification in Peritoneal Dialysis Patients? Unknown status NCT00299572 Phase 4 alendronate (Fosamax)
37 Clinical Trial Technology Development for the Validation of Surrogate Prognostic Markers in Patients With Diabetic Nephropathy Unknown status NCT01673204 Phase 4 Calcitriol;Placebo
38 Effect of Intravenous Acetadote on Incidence of Contrast Induced Nephropathy Unknown status NCT00939913 Phase 4 intravenous NAC;Placebo
39 Clinical Trial to Compare Effectiveness of Diuretics in Hemodialysis Patients With Residual Renal Function Unknown status NCT01977430 Phase 4 Hydrochlorothiazide and furosemide
40 Thiazolidinedione (TZD) on the Diabetic Retinopathy and Nephropathy Unknown status NCT01175486 Phase 4 Actos (Pioglitazone);Acarbose
41 The Effects of Acetylcysteine on Alleviating Damage of Oxidative Stress in Hemodialysis Patients Unknown status NCT00247507 Phase 4 acetylcysteine
42 Effects of Cholecalciferol on Osteoprotegerin Levels in Patients on Peritoneal Dialysis Unknown status NCT02598635 Phase 4 Cholecalciferol;Placebo
43 Ezetimibe/Simvastatin Combination in Proteinuric Nephropathy Unknown status NCT00861731 Phase 4 simvastatin;EZE/simvastatin;EZE/simvastatin
44 Benidipine and Hydrochlorothiazide in Fosinopril Treated Chronic Kidney Disease Patients With Hypertension Unknown status NCT02646397 Phase 4 Fosinopril;Benidipine;Hydrochlorothiazide
45 Revascularization of Renal Artery Stenosis Versus Medical Therapy for the Treatment of Ischemic Nephropathy Unknown status NCT01023373 Phase 4 Medical treatment
46 Effect of Valsartan vs Perindopril on HOMA-IR Index in Patients With Chronic Kidney Disease Unknown status NCT02299310 Phase 4 Valsartan;Perindopril
47 Efficacy and Safety of Abelmoschus Manihot for Chronic Kidney Disease Unknown status NCT02231138 Phase 4 Abelmoschus manihot (AM)
48 Safety and Efficacy of Shenyankangfu Tablets for Chronic Kidney Disease Unknown status NCT02885857 Phase 4 Shenyan Kangfu Tablet
49 Study Evaluating Denosumab on Bone and Vascular Metabolism in Osteoporotic Chronic Kidney Disease Unknown status NCT02792413 Phase 4 Denosumab;NaCl (placebo)
50 Keto-/Amino Acid Supplemented Low Protein Diet in Patients With Chronic Kidney Disease Unknown status NCT00364884 Phase 4 ketoaminoacid

Search NIH Clinical Center for Chronic Kidney Failure

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Chronic Kidney Failure cell therapies at LifeMap Discovery.

Cochrane evidence based reviews: kidney failure, chronic

Genetic Tests for Chronic Kidney Failure

Genetic tests related to Chronic Kidney Failure:

# Genetic test Affiliating Genes
1 Chronic Kidney Disease 30

Anatomical Context for Chronic Kidney Failure

MalaCards organs/tissues related to Chronic Kidney Failure:

42
Kidney, Bone, Heart, Liver, Endothelial, Testes, Neutrophil
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Chronic Kidney Failure:
# Tissue Anatomical CompartmentCell Relevance
1 Bone Bone Marrow Bone Marrow Stromal Cells Potential therapeutic candidate
2 Adipose Subcutaneous White Adipose Mesenchymal Stem Cells Potential therapeutic candidate
3 Kidney Proximal Tubule Proximal Tubule Cells Affected by disease, potential therapeutic candidate
4 Adipose Subcutaneous White Adipose Stromal Cells Potential therapeutic candidate

Publications for Chronic Kidney Failure

Articles related to Chronic Kidney Failure:

(show top 50) (show all 5983)
# Title Authors Year
1
Adrenal crisis presented as acute onset of hypercalcemia and hyponatremia triggered by acute pyelonephritis in a patient with partial hypopituitarism and pre-dialysis chronic kidney disease. ( 30456557 )
2019
2
Chronic kidney disease and aging differentially diminish bone material and microarchitecture in C57Bl/6 mice. ( 31055118 )
2019
3
Regression of chronic kidney disease in a patient with AL amyloidosis: A case report
. ( 30935458 )
2019
4
Molecular mechanisms underlying uremic toxin-related systemic disorders in chronic kidney disease: focused on β2-microglobulin-related amyloidosis and indoxyl sulfate-induced atherosclerosis-Oshima Award Address 2016. ( 29869756 )
2019
5
No Difference in Cognitive Dysfunction Among Patients with ANCA-Associated Vasculitis, Rheumatoid Arthritis or Chronic Kidney Disease. ( 31030697 )
2019
6
Nucleotide-Binding Oligomerization Domain-Like Receptor Protein 3 Deficiency in Vascular Smooth Muscle Cells Prevents Arteriovenous Fistula Failure Despite Chronic Kidney Disease. ( 30587058 )
2019
7
Latent tuberculosis infection and non-infectious co-morbidities: Diabetes mellitus type 2, chronic kidney disease and rheumatoid arthritis. ( 30802622 )
2019
8
Comparison of incidence of acute kidney injury, chronic kidney disease and end-stage renal disease between atrial fibrillation and atrial flutter: real-world evidences from a propensity score-matched national cohort analysis. ( 31073825 )
2019
9
Real-world 2-year outcome of atrial fibrillation treatment with dabigatran, apixaban, and rivaroxaban in patients with and without chronic kidney disease. ( 31073827 )
2019
10
Cerebrovascular events, bleeding complications and device related thrombi in atrial fibrillation patients with chronic kidney disease and left atrial appendage closure with the WATCHMAN™ device. ( 31092201 )
2019
11
Risks of anticoagulation in patients with chronic kidney disease and atrial fibrillation: More than just bleeding? ( 31011695 )
2019
12
Exposure to vitamin k antagonists and kidney function decline in patients with atrial fibrillation and chronic kidney disease. ( 31011705 )
2019
13
Rho kinase activity and atrial fibrillation: insights from chronic kidney disease and dialysis patients. ( 30920496 )
2019
14
Longitudinal kidney function trajectories predict major bleeding, hospitalization and death in patients with atrial fibrillation and chronic kidney disease. ( 30777405 )
2019
15
Short-Term Outcomes in Newly Diagnosed Atrial Fibrillation and Chronic Kidney Disease: How Important Is Ethnicity? ( 30717613 )
2019
16
Management and 1-Year Outcomes of Patients With Newly Diagnosed Atrial Fibrillation and Chronic Kidney Disease: Results From the Prospective GARFIELD - AF Registry. ( 30717616 )
2019
17
Case of psoriasis vulgaris with atrial fibrillation, heart failure and chronic kidney disease which were found accidentally through blood examination during apremilast treatment. ( 30663127 )
2019
18
Chronic kidney disease predicts atrial fibrillation in patients with ST-segment elevation myocardial infarction treated by primary percutaneous coronary intervention. ( 30650039 )
2019
19
Association of metabolic syndrome and chronic kidney disease with atrial fibrillation: A nationwide population-based study in Korea. ( 30578822 )
2019
20
Demystifying the Benefits and Harms of Anticoagulation for Atrial Fibrillation in Chronic Kidney Disease. ( 30593489 )
2019
21
Uncertainty surrounds anticoagulation risks and benefits in patients with chronic kidney disease with atrial fibrillation. ( 30006370 )
2019
22
Baseline characteristics of the autosomal-dominant polycystic kidney disease sub-cohort of the KoreaN cohort study for outcomes in patients with chronic kidney disease. ( 29797773 )
2019
23
Frequency of bacteriuria in dogs with chronic kidney disease: A retrospective study of 201 cases. ( 30767319 )
2019
24
Senescent Cells in Early Vascular Ageing and Bone Disease of Chronic Kidney Disease-A Novel Target for Treatment. ( 30717151 )
2019
25
Clinical impact of advanced chronic kidney disease on outcomes and in-hospital complications of Takotsubo Syndrome (broken-heart-syndrome): Propensity-matched national study. ( 30293663 )
2019
26
Bullous pemphigoid associated with linagliptin treatment in diabetic patients with chronic kidney disease. ( 30630688 )
2019
27
Diffuse tracheobronchial calcinosis in a geriatric patient with chronic kidney disease. ( 31031358 )
2019
28
The use of cinacalcet for the treatment of calciphylaxis in patients with chronic kidney disease: A comprehensive review. ( 30666627 )
2019
29
Clinical Significance of Increased Serum Neopterin in Chronic Kidney Failure as a Biomarker of Cell-mediated Immunity. ( 30820177 )
2019
30
Pharmacological Blockade of Soluble Epoxide Hydrolase Attenuates the Progression of Congestive Heart Failure Combined With Chronic Kidney Disease: Insights From Studies With Fawn-Hooded Hypertensive Rats. ( 30728778 )
2019
31
The impact of chronic kidney disease on lower extremity bypass outcomes in patients with critical limb ischemia. ( 30154013 )
2019
32
Endovascular Therapy Using Diluted Contrast Medium for Critical Limb Ischemia in a Patient with Chronic Kidney Disease. ( 30464136 )
2019
33
Iron Deficiency Anemia in Chronic Kidney Disease. ( 30970355 )
2019
34
Is there association between chronic kidney disease and dental caries? A case-controlled study. ( 30818314 )
2019
35
Depression and neurocognitive dysfunction in pediatric and young adult chronic kidney disease. ( 31049719 )
2019
36
Relationships between illness representations, physical activity and depression in chronic kidney disease. ( 30938078 )
2019
37
Improving the appropriateness of depression treatment in patients with advanced chronic kidney disease. ( 30671913 )
2019
38
Patterns and predictors of depression treatment among adults with chronic kidney disease and depression in ambulatory care settings in the United States. ( 30515735 )
2019
39
Incremental risk of cardiovascular disease and/or chronic kidney disease for future ASCVD and mortality in patients with type 2 diabetes mellitus: ACCORD trial. ( 31088728 )
2019
40
Incremental effects of diabetes mellitus and chronic kidney disease in medial arterial calcification: Synergistic pathways for peripheral artery disease progression. ( 31090495 )
2019
41
Management of diabetes mellitus in chronic kidney disease: an overview. ( 31112029 )
2019
42
Everolimus eluting stents in patients with diabetes mellitus and chronic kidney disease: Insights from the TUXEDO trial. ( 31036397 )
2019
43
Limited Knowledge of Chronic Kidney Disease among Type 2 Diabetes Mellitus Patients in India. ( 31018581 )
2019
44
Association between polymorphism rs2032487 in the non-muscle myosin heavy chain IIA gene (MHY9) and chronic kidney disease secondary to type 2 diabetes mellitus in a population of the Canary Islands. ( 30954444 )
2019
45
A case of acute kidney injury secondary to black cherry concentrate in a patient with chronic kidney disease secondary to type 2 diabetes mellitus. ( 30963415 )
2019
46
Lactic acidosis due to metformin in type 2 diabetes mellitus and chronic kidney disease stage 3-5: is it significant? ( 30963454 )
2019
47
Renoprotective Effects of Additional SGLT2 inhibitor Therapy in Patients With Type 2 Diabetes Mellitus and Chronic Kidney Disease Stages 3b-4: A Real World Report From A Japanese Specialized Diabetes Care Center. ( 30937117 )
2019
48
Carotid intima-media thickness is an independent predictor of all-cause mortality and cardiovascular morbidity in patients with diabetes mellitus type 2 and chronic kidney disease. ( 30909780 )
2019
49
Impact of Diabetes Mellitus and Chronic Kidney Disease on Cardiovascular Outcomes and Platelet P2Y12 Receptor Antagonist Effects in Patients With Acute Coronary Syndromes: Insights From the PLATO Trial. ( 30857464 )
2019
50
SGLT-2 inhibitors and GLP-1 receptor agonists for nephroprotection and cardioprotection in patients with diabetes mellitus and chronic kidney disease. A consensus statement by the EURECA-m and the DIABESITY working groups of the ERA-EDTA. ( 30753708 )
2019

Variations for Chronic Kidney Failure

ClinVar genetic disease variations for Chronic Kidney Failure:

6 (show all 18)
# Gene Variation Type Significance SNP ID Assembly Location
1 CEL NM_001807.4(CEL): c.1975G> C (p.Ala659Pro) single nucleotide variant Uncertain significance rs587780309 GRCh37 Chromosome 9, 135946855: 135946855
2 CEL NM_001807.4(CEL): c.1975G> C (p.Ala659Pro) single nucleotide variant Uncertain significance rs587780309 GRCh38 Chromosome 9, 133071468: 133071468
3 SLC13A5 NM_177550.4(SLC13A5): c.231+2T> G single nucleotide variant Likely pathogenic rs730882222 GRCh38 Chromosome 17, 6707026: 6707026
4 SLC13A5 NM_177550.4(SLC13A5): c.231+2T> G single nucleotide variant Likely pathogenic rs730882222 GRCh37 Chromosome 17, 6610345: 6610345
5 MKS1 NM_017777.3(MKS1): c.1115_1117delCCT (p.Ser372del) deletion Pathogenic/Likely pathogenic rs754279998 GRCh37 Chromosome 17, 56285514: 56285516
6 MKS1 NM_017777.3(MKS1): c.1115_1117delCCT (p.Ser372del) deletion Pathogenic/Likely pathogenic rs754279998 GRCh38 Chromosome 17, 58208153: 58208155
7 COL4A4 NM_000092.4(COL4A4): c.4217-15T> C single nucleotide variant Conflicting interpretations of pathogenicity rs200926310 GRCh37 Chromosome 2, 227877028: 227877028
8