MCID: CHR057
MIFTS: 34

Chronic Laryngitis

Categories: Infectious diseases, Oral diseases, Respiratory diseases

Aliases & Classifications for Chronic Laryngitis

MalaCards integrated aliases for Chronic Laryngitis:

Name: Chronic Laryngitis 12 15 70 32

Classifications:



External Ids:

Disease Ontology 12 DOID:11797
ICD9CM 34 476.0
NCIt 50 C26975
SNOMED-CT 67 155535001
ICD10 32 J37.0
UMLS 70 C0155836

Summaries for Chronic Laryngitis

Disease Ontology : 12 A laryngitis in which symptoms last longer than three weeks. Gastroesophageal reflux, and lingering bronchitis can cause the disease.

MalaCards based summary : Chronic Laryngitis is related to laryngitis and gastroesophageal reflux. An important gene associated with Chronic Laryngitis is ATP12A (ATPase H+/K+ Transporting Non-Gastric Alpha2 Subunit), and among its related pathways/superpathways are Tight junction and Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. The drugs Amitriptyline and Perphenazine have been mentioned in the context of this disorder. Affiliated tissues include trachea.

Related Diseases for Chronic Laryngitis

Diseases in the Laryngitis family:

Chronic Laryngitis Viral Laryngitis
Acute Laryngitis

Diseases related to Chronic Laryngitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 205)
# Related Disease Score Top Affiliating Genes
1 laryngitis 31.3 HRH2 ATP4A ATP12A
2 gastroesophageal reflux 30.6 HRH2 ATP4A ATP12A
3 acute laryngitis 30.4 ATP4A ATP12A
4 laryngeal tuberculosis 30.2 ATP4A ATP12A
5 peptic esophagitis 30.0 HRH2 ATP4A ATP12A
6 hernia, hiatus 29.8 HRH2 ATP4A ATP12A
7 vagus nerve disease 10.2 ATP4A ATP12A
8 necrotizing gastritis 10.2 ATP4A ATP12A
9 scalp dermatosis 10.2 ATP4A ATP12A
10 hemangioma of intra-abdominal structure 10.2 ATP4A ATP12A
11 acquired gastric outlet stenosis 10.2 ATP4A ATP12A
12 lingual goiter 10.2 ATP4A ATP12A
13 displacement of cardia through esophageal hiatus 10.2 ATP4A ATP12A
14 bacterial esophagitis 10.2 ATP4A ATP12A
15 benzylpenicillin allergy 10.2 ATP4A ATP12A
16 median arcuate ligament syndrome 10.2 ATP4A ATP12A
17 afferent loop syndrome 10.2 ATP4A ATP12A
18 cervix erosion 10.2 ATP4A ATP12A
19 angiodysplasia of intestine 10.2 ATP4A ATP12A
20 angiodysplasia 10.2 ATP4A ATP12A
21 granulomatous gastritis 10.2 ATP4A ATP12A
22 fungal esophagitis 10.2 ATP4A ATP12A
23 dieulafoy lesion 10.2 ATP4A ATP12A
24 esophagus melanoma 10.2 ATP4A ATP12A
25 cefuroxime allergy 10.2 ATP4A ATP12A
26 emphysematous cholecystitis 10.2 ATP4A ATP12A
27 gastric gastrinoma 10.2 ATP4A ATP12A
28 pneumatosis cystoides intestinalis 10.2 ATP4A ATP12A
29 viral laryngitis 10.2 ATP4A ATP12A
30 gastroduodenal crohn's disease 10.2 ATP4A ATP12A
31 polyposis, skin pigmentation, alopecia, and fingernail changes 10.2 ATP4A ATP12A
32 central nervous system origin vertigo 10.2 ATP4A ATP12A
33 rumination disorder 10.2 ATP4A ATP12A
34 internal hemorrhoid 10.2 ATP4A ATP12A
35 hemorrhoid 10.2 ATP4A ATP12A
36 gastroduodenitis 10.2 ATP4A ATP12A
37 duodenitis 10.2 ATP4A ATP12A
38 chronic intestinal vascular insufficiency 10.2 ATP4A ATP12A
39 barbiturate abuse 10.2 ATP4A ATP12A
40 gastric dilatation 10.2 ATP4A ATP12A
41 gastric hemangioma 10.2 ATP4A ATP12A
42 blind loop syndrome 10.2 ATP4A ATP12A
43 polycystic echinococcosis 10.2 ATP4A ATP12A
44 diclofenac allergy 10.2 ATP4A ATP12A
45 lymphocytic gastritis 10.2 ATP4A ATP12A
46 x-linked chondrodysplasia punctata 1 10.2 ATP4A ATP12A
47 mediastinitis 10.2 ATP4A ATP12A
48 duodenal obstruction 10.2 ATP4A ATP12A
49 epidermolysis bullosa simplex, ogna type 10.2 ATP4A ATP12A
50 gastric antral vascular ectasia 10.2 ATP4A ATP12A

Comorbidity relations with Chronic Laryngitis via Phenotypic Disease Network (PDN):


Bronchitis

Graphical network of the top 20 diseases related to Chronic Laryngitis:



Diseases related to Chronic Laryngitis

Symptoms & Phenotypes for Chronic Laryngitis

Drugs & Therapeutics for Chronic Laryngitis

Drugs for Chronic Laryngitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amitriptyline Approved Phase 2, Phase 3 50-48-6 2160
2
Perphenazine Approved Phase 2, Phase 3 58-39-9 4748
3 Antidepressive Agents Phase 2, Phase 3
4 Psychotropic Drugs Phase 2, Phase 3
5 Analgesics, Non-Narcotic Phase 2, Phase 3
6 Neurotransmitter Agents Phase 2, Phase 3
7 Amitriptyline, perphenazine drug combination Phase 2, Phase 3
8 Analgesics Phase 2, Phase 3
9 Adrenergic Agents Phase 2, Phase 3
10 Antipsychotic Agents Phase 2, Phase 3
11 Antidepressive Agents, Tricyclic Phase 2, Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Double-blind Placebo Controlled Trial of the Treatment of Chronic Laryngitis With Amitriptyline Recruiting NCT02552225 Phase 2, Phase 3 Amitriptyline
2 Double-blind Placebo Controlled Trial of the Treatment of Chronic Laryngitis With Amitryptiline Terminated NCT02434523 Phase 2, Phase 3 Amitriptyline

Search NIH Clinical Center for Chronic Laryngitis

Genetic Tests for Chronic Laryngitis

Anatomical Context for Chronic Laryngitis

MalaCards organs/tissues related to Chronic Laryngitis:

40
Trachea

Publications for Chronic Laryngitis

Articles related to Chronic Laryngitis:

(show top 50) (show all 272)
# Title Authors PMID Year
1
Otolaryngeal and Oropharyngeal Conditions: Dysphonia. 61
33595263 2021
2
Helicobacter pylori gastric infection in patients with laryngeal cancer and chronic laryngitis. 61
32621246 2021
3
Sensitivity, Specificity, and Reproducibility of the Brazilian Portuguese Version of the Reflux Symptom Index. 61
31586513 2021
4
The Importance of Inspiratory Maneuver for Benign Laryngeal Lesions. 61
33101520 2020
5
Extranasal Manifestations of Allergy in the Head and Neck. 61
32430587 2020
6
Validation of the Brazilian Portuguese Version of the Reflux Finding Score. 61
32057613 2020
7
Pump Proton and Laryngeal H+/K+ ATPases. 61
33363399 2020
8
Chronic laryngitis caused by Mycobacterium Kansasii in a traveler. 61
30912581 2019
9
Characteristics of swallowing disorders in patients with dysphonia. 61
32022701 2019
10
Association of Sinonasal Factors With Chronic Laryngitis in Korean Adults. 61
31415057 2019
11
Identification and Management of Chronic Laryngitis. 61
31101358 2019
12
Allergic laryngitis: chronic laryngitis and allergic sensitization. 61
30898484 2019
13
Laryngeal Cryptococcosis: An Evolving Rare Clinical Entity. 61
30678486 2019
14
[Influence of TNF-α on the immunomodulatory property of laryngeal mucosa mesenchymal stromal cells']. 61
30909341 2019
15
A comparative and correlative study of the Voice-Related Quality of Life (V-RQOL) and the Voice Activity and Participation Profile (VAPP) for voice-related quality of life among teachers with and without voice disorders. 61
30817565 2019
16
[Acute and chronic laryngitis in the subjects engaged in the voice and speech professions]. 61
30938347 2019
17
ARE THE PERSISTENT SYMPTOMS TO PROTON PUMP INHIBITOR THERAPY DUE TO REFRACTORY GASTROESOPHAGEAL REFLUX DISEASE OR TO OTHER DISORDERS? 61
30304291 2018
18
Changes After Voice Therapy in Acoustic Voice Analysis of Chinese Patients With Voice Disorders. 61
28606663 2018
19
Pharmacologic management of voice disorders by general medicine providers and otolaryngologists. 61
28944537 2018
20
Adaptation and validation of Mandarin Chinese version of the pediatric Voice Handicap Index (pVHI). 61
29287865 2018
21
[The treatment of laryngomycosis]. 61
29953053 2018
22
Insulin Resistance is Associated with Chronic Laryngitis in Korean Women. 61
29582885 2018
23
Korean survey data reveals an association of chronic laryngitis with tinnitus in men. 61
29324903 2018
24
Adaptation and validation of the Singing Voice Handicap Index into Polish. 61
28107611 2017
25
Chronic Large Non Healing Ulcer: Non-Tuberculous Mycobacterial Infection of the Laryngopharynx. 61
29026492 2017
26
A Comparative Study of the VHI-10 and the V-RQOL for Quality of Life Among Chinese Teachers With and Without Voice Disorders. 61
28041640 2017
27
Allergic laryngitis: unraveling the myths. 61
28266945 2017
28
Czy smog ma wpływ na częstość występowania zaostrzeń przewlekłego zapalenia krtani? Analiza na przykładzie mieszkańców województwa małopolskiego. 61
28541243 2017
29
[The use of fenspiride for the combined treatment of exacerbation of chronic laryngitis]. 61
29260786 2017
30
[The prevalence of the fungal flora in association with chronic inflammatory pathology of the larynx]. 61
28980592 2017
31
Efficacy of acid suppression therapy in gastroesophageal reflux disease-related chronic laryngitis. 61
27749540 2016
32
Aphthous Ulcer of the Vocal Cord Leading to Hoarseness. 61
27648652 2016
33
MicroRNA-133a suppresses the proliferation, migration, and invasion of laryngeal carcinoma cells by targeting CD47. 61
27730543 2016
34
The human laryngeal microbiome: effects of cigarette smoke and reflux. 61
27775059 2016
35
Hoarseness – causes and treatments. 61
29979539 2016
36
Prevalence of chronic cough and possible causes in the general population based on the Korean National Health and Nutrition Examination Survey. 61
27631208 2016
37
EXTRADIGESTIVE MANIFESTATIONS OF GASTROESOPHAGEAL REFLUX DISEASE: DEMOGRAPHIC, CLINICAL, BIOLOGICAL AND ENDOSCOPIC FEATURES. 61
27483705 2016
38
Toward an Understanding of the Pathophysiology of Chronic Laryngitis. 61
32864454 2016
39
Voice disorders in the elderly: A national database study. 61
26280350 2016
40
[The treatment of exacerbations of chronic laryngitis in the vocal professionals]. 61
27213657 2016
41
[The frequency and clinical aspects of extraesophageal syndromes in elderly patients with gastroesophageal reflux disease]. 61
27030180 2016
42
[The state of the larynx in the patients presenting with chronic obstructive pulmonary disease]. 61
26977564 2016
43
Soot and house dust mite allergen cause eosinophilic laryngitis in an animal model. 61
26197967 2016
44
The role of biofilm in chronic laryngitis and in head and neck cancer. 61
26371604 2015
45
Metabolic Syndrome and Chronic Laryngitis: The Korean National Health and Nutrition Examination Survey 2008 to 2010. 61
26512606 2015
46
Hoarseness-causes and treatments. 61
26043420 2015
47
Association between Obesity and Chronic Laryngitis in Women--Data from the Korea National Health and Nutrition Examination Survey. 61
26138994 2015
48
Association between Chronic Laryngitis and Particulate Matter Based on the Korea National Health and Nutrition Examination Survey 2008-2012. 61
26177353 2015
49
[Value of narrow band imaging endoscopy in detection of early laryngeal squamous cell carcinoma]. 61
25882022 2015
50
Frequency and factors associated with use of videolaryngostroboscopy in voice disorder assessment. 61
24659429 2014

Variations for Chronic Laryngitis

Expression for Chronic Laryngitis

Search GEO for disease gene expression data for Chronic Laryngitis.

Pathways for Chronic Laryngitis

GO Terms for Chronic Laryngitis

Cellular components related to Chronic Laryngitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of membrane GO:0016021 9.8 HRH2 CD1E CD1D CD1B CD1A ATP4A
2 extracellular space GO:0005615 9.72 CD1E CD1D CD1B CD1A ATP4A
3 lysosome GO:0005764 9.58 CD1E CD1D CD1B
4 endosome membrane GO:0010008 9.54 CD1D CD1B CD1A
5 endosome GO:0005768 9.46 CD1E CD1D CD1B CD1A
6 integral component of plasma membrane GO:0005887 9.35 HRH2 CD1E CD1D CD1A ATP4A
7 external side of plasma membrane GO:0009897 8.92 CD1E CD1D CD1B CD1A

Biological processes related to Chronic Laryngitis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.78 CD1E CD1D CD1B CD1A
2 immune response GO:0006955 9.65 HRH2 CD1E CD1D CD1B CD1A
3 regulation of immune response GO:0050776 9.63 CD1D CD1B CD1A
4 potassium ion import across plasma membrane GO:1990573 9.49 ATP4A ATP12A
5 positive regulation of T cell mediated cytotoxicity GO:0001916 9.46 CD1E CD1D CD1B CD1A
6 cellular sodium ion homeostasis GO:0006883 9.43 ATP4A ATP12A
7 sodium ion export across plasma membrane GO:0036376 9.4 ATP4A ATP12A
8 cellular potassium ion homeostasis GO:0030007 9.37 ATP4A ATP12A
9 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.32 ATP4A ATP12A
10 antigen processing and presentation, exogenous lipid antigen via MHC class Ib GO:0048007 9.26 CD1E CD1D CD1B CD1A
11 antigen processing and presentation, endogenous lipid antigen via MHC class Ib GO:0048006 8.92 CD1E CD1D CD1B CD1A

Molecular functions related to Chronic Laryngitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopeptide binding GO:0071723 9.46 CD1E CD1D CD1B CD1A
2 sodium:potassium-exchanging ATPase activity GO:0005391 9.37 ATP4A ATP12A
3 potassium-transporting ATPase activity GO:0008556 9.32 ATP4A ATP12A
4 potassium:proton exchanging ATPase activity GO:0008900 9.26 ATP4A ATP12A
5 exogenous lipid antigen binding GO:0030884 9.26 CD1E CD1D CD1B CD1A
6 endogenous lipid antigen binding GO:0030883 8.92 CD1E CD1D CD1B CD1A

Sources for Chronic Laryngitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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