MCID: CHR057
MIFTS: 37

Chronic Laryngitis

Categories: Infectious diseases, Oral diseases, Respiratory diseases

Aliases & Classifications for Chronic Laryngitis

MalaCards integrated aliases for Chronic Laryngitis:

Name: Chronic Laryngitis 12 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:11797
ICD9CM 36 476.0
NCIt 51 C26975
SNOMED-CT 69 29951006
ICD10 34 J37.0
UMLS 74 C0155836

Summaries for Chronic Laryngitis

Disease Ontology : 12 A laryngitis in which symptoms last longer than three weeks. Gastroesophageal reflux, and lingering bronchitis can cause the disease.

MalaCards based summary : Chronic Laryngitis is related to laryngitis and acute laryngitis. An important gene associated with Chronic Laryngitis is ATP12A (ATPase H+/K+ Transporting Non-Gastric Alpha2 Subunit), and among its related pathways/superpathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Tight junction. The drugs Amitriptyline and Perphenazine have been mentioned in the context of this disorder. Affiliated tissues include trachea, skin and thymus.

Related Diseases for Chronic Laryngitis

Diseases in the Laryngitis family:

Chronic Laryngitis Viral Laryngitis
Acute Laryngitis

Diseases related to Chronic Laryngitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 72)
# Related Disease Score Top Affiliating Genes
1 laryngitis 31.3 ATP12A ATP4A HRH2
2 acute laryngitis 30.1 ATP12A ATP4A
3 fungal esophagitis 10.5 ATP12A ATP4A
4 diclofenac allergy 10.5 ATP12A ATP4A
5 gastroduodenal crohn's disease 10.5 ATP12A ATP4A
6 neonatal candidiasis 10.5 ATP12A ATP4A
7 photoallergic dermatitis 10.5 ATP12A ATP4A
8 squamous papillomatosis 10.5 ATP12A ATP4A
9 toxic megacolon 10.4 ATP12A ATP4A
10 gastrointestinal neuroendocrine benign tumor 10.4 ATP12A ATP4A
11 gastric antral vascular ectasia 10.4 ATP12A ATP4A
12 granulomatous gastritis 10.4 ATP12A ATP4A
13 gastric neuroendocrine neoplasm 10.4 ATP12A ATP4A
14 duodenitis 10.4 ATP12A ATP4A
15 rumination disorder 10.4 ATP12A ATP4A
16 congenital disorder of deglycosylation 10.4 ATP12A ATP4A
17 bladder calculus 10.4 ATP12A ATP4A
18 ischemic neuropathy 10.4 ATP12A ATP4A
19 bile reflux 10.4 ATP12A ATP4A
20 capillary disease 10.4 ATP12A ATP4A
21 dyskinesia of esophagus 10.4 ATP12A ATP4A
22 anismus 10.4 ATP12A ATP4A
23 postsurgical hypothyroidism 10.4 ATP12A ATP4A
24 lymphocytic colitis 10.4 ATP12A ATP4A
25 esophageal atresia/tracheoesophageal fistula 10.4 ATP12A ATP4A
26 clostridium difficile colitis 10.4 ATP12A ATP4A
27 diarrhea 1, secretory chloride, congenital 10.4 ATP12A ATP4A
28 esophagitis, eosinophilic, 1 10.4 ATP12A ATP4A
29 microscopic colitis 10.4 ATP12A ATP4A
30 laryngeal tuberculosis 10.4 ATP12A ATP4A
31 eosinophilic gastritis 10.4 ATP12A ATP4A
32 esophagus adenocarcinoma 10.4 ATP12A ATP4A
33 chronic intestinal vascular insufficiency 10.4 ATP12A ATP4A
34 polyposis, skin pigmentation, alopecia, and fingernail changes 10.4 ATP12A ATP4A
35 multifocal motor neuropathy 10.4 CD1A CD1E
36 jejunoileitis 10.3 ATP12A ATP4A
37 pancreatic steatorrhea 10.3 ATP12A ATP4A
38 esophageal varix 10.3 ATP12A ATP4A
39 aspiration pneumonitis 10.3 ATP12A ATP4A HRH2
40 active peptic ulcer disease 10.3 ATP12A ATP4A HRH2
41 blind loop syndrome 10.3 ATP12A ATP4A HRH2
42 superior mesenteric artery syndrome 10.3 ATP12A ATP4A
43 functional gastric disease 10.3 ATP12A ATP4A HRH2
44 peptic ulcer perforation 10.3 ATP12A ATP4A HRH2
45 esophageal disease 10.3 ATP12A ATP4A HRH2
46 stomach disease 10.3 ATP12A ATP4A HRH2
47 laryngotracheitis 10.3
48 gastric lymphoma 10.3 ATP12A ATP4A
49 esophageal candidiasis 10.3 ATP12A ATP4A CYP2C19
50 hernia, hiatus 10.3 ATP12A ATP4A CYP2C19

Comorbidity relations with Chronic Laryngitis via Phenotypic Disease Network (PDN):


Bronchitis

Graphical network of the top 20 diseases related to Chronic Laryngitis:



Diseases related to Chronic Laryngitis

Symptoms & Phenotypes for Chronic Laryngitis

Drugs & Therapeutics for Chronic Laryngitis

Drugs for Chronic Laryngitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amitriptyline Approved Phase 2, Phase 3,Phase 3 50-48-6 2160
2
Perphenazine Approved Phase 2, Phase 3,Phase 3 58-39-9 4748
3 Antipsychotic Agents Phase 2, Phase 3,Phase 3
4 Analgesics Phase 2, Phase 3,Phase 3
5 Antidepressive Agents Phase 2, Phase 3,Phase 3
6 Antidepressive Agents, Tricyclic Phase 2, Phase 3,Phase 3
7 Adrenergic Agents Phase 2, Phase 3,Phase 3
8 Neurotransmitter Agents Phase 2, Phase 3,Phase 3
9 Peripheral Nervous System Agents Phase 2, Phase 3,Phase 3
10 Central Nervous System Depressants Phase 2, Phase 3,Phase 3
11 Tranquilizing Agents Phase 2, Phase 3,Phase 3
12 Neurotransmitter Uptake Inhibitors Phase 2, Phase 3,Phase 3
13 Amitriptyline, perphenazine drug combination Phase 2, Phase 3,Phase 3
14 Analgesics, Non-Narcotic Phase 2, Phase 3,Phase 3
15 Psychotropic Drugs Phase 2, Phase 3,Phase 3
16
Omeprazole Approved, Investigational, Vet_approved 73590-58-6 4594
17 Mitogens Not Applicable
18 Gastrointestinal Agents
19 Proton Pump Inhibitors
20 Anti-Ulcer Agents
21 Antacids

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treatment of Chronic Laryngitis With Amitriptyline Suspended NCT02552225 Phase 2, Phase 3 Amitriptyline
2 Trial of the Treatment of Chronic Laryngitis With Amitryptiline Terminated NCT02434523 Phase 2, Phase 3 Amitriptyline
3 Laryngeal and Esophageal EGF-r Expression in Patients With Reflux Laryngitis Completed NCT01806220 Not Applicable
4 Salivary Epidermal Growth Factor (EGF) Concentration Before and After Treatment of Reflux Laryngitis Completed NCT01389401 omeprazole

Search NIH Clinical Center for Chronic Laryngitis

Genetic Tests for Chronic Laryngitis

Anatomical Context for Chronic Laryngitis

MalaCards organs/tissues related to Chronic Laryngitis:

42
Trachea, Skin, Thymus

Publications for Chronic Laryngitis

Articles related to Chronic Laryngitis:

(show top 50) (show all 60)
# Title Authors Year
1
Allergic laryngitis: chronic laryngitis and allergic sensitization. ( 30898484 )
2019
2
Chronic laryngitis caused by Mycobacterium Kansasii in a traveler. ( 30912581 )
2019
3
Identification and Management of Chronic Laryngitis. ( 31101358 )
2019
4
Korean survey data reveals an association of chronic laryngitis with tinnitus in men. ( 29324903 )
2018
5
Insulin Resistance is Associated with Chronic Laryngitis in Korean Women. ( 29582885 )
2018
6
Efficacy of acid suppression therapy in gastroesophageal reflux disease-related chronic laryngitis. ( 27749540 )
2016
7
Association between Obesity and Chronic Laryngitis in Women--Data from the Korea National Health and Nutrition Examination Survey. ( 26138994 )
2015
8
Association between Chronic Laryngitis and Particulate Matter Based on the Korea National Health and Nutrition Examination Survey 2008-2012. ( 26177353 )
2015
9
The role of biofilm in chronic laryngitis and in head and neck cancer. ( 26371604 )
2015
10
Metabolic Syndrome and Chronic Laryngitis: The Korean National Health and Nutrition Examination Survey 2008 to 2010. ( 26512606 )
2015
11
Detection of chronic laryngitis due to laryngopharyngeal reflux using color and texture analysis of laryngoscopic images. ( 24314831 )
2014
12
Acute laryngitis superimposed on chronic laryngitis. ( 23460211 )
2013
13
An oropharyngeal pH monitoring device to evaluate patients with chronic laryngitis. ( 23495894 )
2013
14
Incidence of chronic laryngitis. ( 24592580 )
2013
15
[Perceptual and automatic voice and speech analysis of chronic laryngitis and T1 vocal cord cancer]. ( 23744089 )
2013
16
Comparison of patients of chronic laryngitis with and without troublesome reflux symptoms. ( 21793907 )
2012
17
Predictors of acid suppression success in patients with chronic laryngitis. ( 22276941 )
2012
18
Bacterial biofilm associated with chronic laryngitis. ( 22652944 )
2012
19
Effect of pantoprazole in patients with chronic laryngitis and pharyngitis related to gastroesophageal reflux disease: clinical, proximal, and distal pH monitoring results. ( 20002704 )
2010
20
Benefit of acid-suppressive therapy in chronic laryngitis: the devil is in the details. ( 20621625 )
2010
21
Dilated intercellular space in chronic laryngitis and gastro-oesophageal reflux disease: at baseline and post-lansoprazole therapy. ( 20735783 )
2010
22
Gastroesophageal reflux-related chronic laryngitis: con. ( 20855684 )
2010
23
GERD-related chronic laryngitis: pro. ( 20855685 )
2010
24
Gastroesophageal reflux-related chronic laryngitis. Commentary. ( 20855686 )
2010
25
Gastro-oesophageal reflux disease in chronic laryngitis: prevalence and response to acid-suppressive therapy. ( 17269990 )
2007
26
Salivary egf concentration in adults with reflux chronic laryngitis before and after treatment: preliminary results. ( 17589721 )
2007
27
Chronic laryngitis associated with gastroesophageal reflux: prospective assessment of differences in practice patterns between gastroenterologists and ENT physicians. ( 16542282 )
2006
28
Proton pump inhibitor therapy for suspected GERD-related chronic laryngitis: a meta-analysis of randomized controlled trials. ( 17037995 )
2006
29
Chronic laryngitis in glassblowers. ( 15895845 )
2005
30
Improvement in clinical course and laryngeal appearance in selected patients with chronic laryngitis after eight weeks of therapy with rabeprazole. ( 15448612 )
2004
31
Severe chronic laryngitis mimicking a granulomatous disease. ( 15628624 )
2004
32
Interaction of sleep disturbances and gastroesophageal reflux in chronic laryngitis. ( 11791245 )
2002
33
Diagnosis and management of chronic laryngitis associated with reflux. ( 10718463 )
2000
34
Role of esophageal pH recording in management of chronic laryngitis: an overview. ( 11051423 )
2000
35
Absence of bacterial infection in the mucosal secretion in chronic laryngitis. ( 11081617 )
2000
36
A possible role of helicobacter pylori infection in the etiology of chronic laryngitis. ( 23119449 )
1998
37
Langerhans and other immunocompetent cells in vocal cord epithelial hyperplastic lesions of patients with chronic laryngitis. ( 9197489 )
1997
38
A possible role of Helicobacter pylori infection in the etiology of chronic laryngitis. ( 9438124 )
1997
39
[Serum dihydrotestosterone versus total testosterone values of patients with laryngeal carcinomas and chronic laryngitis]. ( 8766382 )
1996
40
Outcomes of antireflux therapy for the treatment of chronic laryngitis. ( 7598368 )
1995
41
Herpes simplex chronic laryngitis and vocal cord lesions in a patient with acquired immunodeficiency syndrome. ( 8085735 )
1994
42
Chronic laryngitis. ( 1031346 )
1976
43
The aetiology of chronic laryngitis. ( 1031354 )
1976
44
Vitamin A and chronic laryngitis. ( 4109003 )
1972
45
CHRONIC LARYNGITIS. ( 14302922 )
1965
46
The importance of chronic laryngitis. ( 13825824 )
1960
47
Contribution to treatment of chronic laryngitis in persons who use their voices professionally. ( 21024466 )
1945
48
Prominence of the Cartilages of Santorini and Wrisberg accompanied by Chronic Laryngitis. ( 19988473 )
1931
49
Slide showing Section of a Gland removed from a man with Chronic Laryngitis and an Enlarged Gland in the Neck. ( 19983734 )
1924
50
Case of Chronic Laryngitis of Long Standing. ( 19982948 )
1923

Variations for Chronic Laryngitis

Expression for Chronic Laryngitis

Search GEO for disease gene expression data for Chronic Laryngitis.

Pathways for Chronic Laryngitis

Pathways related to Chronic Laryngitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.59 CD1A CD1B CD1C CD1D
2 11.58 CD1A CD1B CD1C CD1D CD1E
3 11.37 CD1A CD1C CD1D
4 11.09 CD1A CD1B CD1C CD1D CD1E GP5
5 9.96 ATP4A HRH2

GO Terms for Chronic Laryngitis

Cellular components related to Chronic Laryngitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.97 ATP12A ATP4A CD1A CD1B CD1C CD1D
2 endosome GO:0005768 9.83 CD1A CD1B CD1C CD1D CD1E
3 lysosome GO:0005764 9.72 CD1B CD1C CD1D CD1E FASLG
4 endosome membrane GO:0010008 9.67 CD1A CD1B CD1C CD1D
5 Ada2/Gcn5/Ada3 transcription activator complex GO:0005671 9.46 KAT2A KAT2B
6 integral component of plasma membrane GO:0005887 9.32 ATP4A CD1A CD1C CD1D CD1E CD47
7 cell surface GO:0009986 9.26 CD1B CD1D CD47 FASLG
8 membrane GO:0016020 10.25 ATP12A ATP4A CD1A CD1B CD1C CD1D
9 integral component of membrane GO:0016021 10.07 ATP12A ATP4A CD1A CD1B CD1C CD1D

Biological processes related to Chronic Laryngitis according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.85 CD1A CD1B CD1C CD1D CD1E
2 adaptive immune response GO:0002250 9.81 CD1A CD1B CD1C CD1E
3 immune response GO:0006955 9.8 CD1A CD1B CD1C CD1D CD1E FASLG
4 regulation of immune response GO:0050776 9.73 CD1A CD1B CD1C CD1D
5 ATP hydrolysis coupled proton transport GO:0015991 9.56 ATP12A ATP4A
6 heterotypic cell-cell adhesion GO:0034113 9.55 CD1D CD47
7 positive regulation of T cell mediated cytotoxicity GO:0001916 9.55 CD1A CD1B CD1C CD1D CD1E
8 cellular sodium ion homeostasis GO:0006883 9.54 ATP12A ATP4A
9 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.52 ATP12A ATP4A
10 cellular potassium ion homeostasis GO:0030007 9.49 ATP12A ATP4A
11 sodium ion export across plasma membrane GO:0036376 9.48 ATP12A ATP4A
12 negative regulation of centriole replication GO:0046600 9.4 KAT2A KAT2B
13 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter GO:0035948 9.37 KAT2A KAT2B
14 antigen processing and presentation, exogenous lipid antigen via MHC class Ib GO:0048007 9.35 CD1A CD1B CD1C CD1D CD1E
15 internal peptidyl-lysine acetylation GO:0018393 9.32 KAT2A KAT2B
16 antigen processing and presentation, endogenous lipid antigen via MHC class Ib GO:0048006 9.02 CD1A CD1B CD1C CD1D CD1E

Molecular functions related to Chronic Laryngitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopeptide binding GO:0071723 9.55 CD1A CD1B CD1C CD1D CD1E
2 acetyltransferase activity GO:0016407 9.4 KAT2A KAT2B
3 sodium:potassium-exchanging ATPase activity GO:0005391 9.37 ATP12A ATP4A
4 endogenous lipid antigen binding GO:0030883 9.35 CD1A CD1B CD1C CD1D CD1E
5 peptide-lysine-N-acetyltransferase activity GO:0061733 9.32 KAT2A KAT2B
6 potassium:proton exchanging ATPase activity GO:0008900 9.26 ATP12A ATP4A
7 exogenous lipid antigen binding GO:0030884 9.02 CD1A CD1B CD1C CD1D CD1E

Sources for Chronic Laryngitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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