MCID: CHR057
MIFTS: 35

Chronic Laryngitis

Categories: Infectious diseases, Oral diseases, Respiratory diseases

Aliases & Classifications for Chronic Laryngitis

MalaCards integrated aliases for Chronic Laryngitis:

Name: Chronic Laryngitis 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:11797
ICD10 33 J37.0
ICD9CM 35 476.0
NCIt 50 C26975
SNOMED-CT 68 29951006
UMLS 73 C0155836

Summaries for Chronic Laryngitis

Disease Ontology : 12 A laryngitis in which symptoms last longer than three weeks. Gastroesophageal reflux, and lingering bronchitis can cause the disease.

MalaCards based summary : Chronic Laryngitis is related to laryngitis and acute laryngitis. An important gene associated with Chronic Laryngitis is ATP12A (ATPase H+/K+ Transporting Non-Gastric Alpha2 Subunit), and among its related pathways/superpathways are Salivary secretion and Secretion of Hydrochloric Acid in Parietal Cells. The drugs Amitriptyline and Perphenazine have been mentioned in the context of this disorder. Affiliated tissues include trachea and skin, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Chronic Laryngitis

Diseases in the Laryngitis family:

Chronic Laryngitis Viral Laryngitis
Acute Laryngitis

Diseases related to Chronic Laryngitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 69)
# Related Disease Score Top Affiliating Genes
1 laryngitis 31.1 ATP12A ATP4A HRH2
2 acute laryngitis 29.9 ATP12A ATP4A
3 fungal esophagitis 10.3 ATP12A ATP4A
4 diclofenac allergy 10.3 ATP12A ATP4A
5 gastroduodenal crohn's disease 10.3 ATP12A ATP4A
6 neonatal candidiasis 10.3 ATP12A ATP4A
7 photoallergic dermatitis 10.3 ATP12A ATP4A
8 squamous papillomatosis 10.3 ATP12A ATP4A
9 toxic megacolon 10.3 ATP12A ATP4A
10 gastrointestinal neuroendocrine benign tumor 10.3 ATP12A ATP4A
11 gastric antral vascular ectasia 10.3 ATP12A ATP4A
12 granulomatous gastritis 10.3 ATP12A ATP4A
13 gastric neuroendocrine neoplasm 10.3 ATP12A ATP4A
14 duodenitis 10.3 ATP12A ATP4A
15 rumination disorder 10.3 ATP12A ATP4A
16 congenital disorder of deglycosylation 10.3 ATP12A ATP4A
17 bladder calculus 10.3 ATP12A ATP4A
18 ischemic neuropathy 10.3 ATP12A ATP4A
19 bile reflux 10.3 ATP12A ATP4A
20 capillary disease 10.3 ATP12A ATP4A
21 dyskinesia of esophagus 10.3 ATP12A ATP4A
22 anismus 10.3 ATP12A ATP4A
23 postsurgical hypothyroidism 10.3 ATP12A ATP4A
24 lymphocytic colitis 10.3 ATP12A ATP4A
25 esophageal atresia/tracheoesophageal fistula 10.3 ATP12A ATP4A
26 clostridium difficile colitis 10.3 ATP12A ATP4A
27 diarrhea 1, secretory chloride, congenital 10.3 ATP12A ATP4A
28 eosinophilic gastritis 10.3 ATP12A ATP4A
29 laryngotracheitis 10.3
30 esophagus adenocarcinoma 10.3 ATP12A ATP4A
31 chronic intestinal vascular insufficiency 10.3 ATP12A ATP4A
32 jejunoileitis 10.3 ATP12A ATP4A
33 pancreatic steatorrhea 10.2 ATP12A ATP4A
34 esophageal varix 10.2 ATP12A ATP4A
35 duodenal disease 10.2 ATP12A ATP4A
36 gastric lymphoma 10.2 ATP12A ATP4A
37 lower urinary tract calculus 10.2 ATP12A ATP4A
38 aspiration pneumonitis 10.2 ATP12A ATP4A HRH2
39 active peptic ulcer disease 10.2 ATP12A ATP4A HRH2
40 esophageal candidiasis 10.2 ATP12A ATP4A CYP2C19
41 blind loop syndrome 10.2 ATP12A ATP4A HRH2
42 myopathy, x-linked, with excessive autophagy 10.2 ATP12A ATP4A
43 functional gastric disease 10.2 ATP12A ATP4A HRH2
44 hernia, hiatus 10.2 ATP12A ATP4A CYP2C19
45 peptic ulcer perforation 10.2 ATP12A ATP4A HRH2
46 esophageal disease 10.2 ATP12A ATP4A HRH2
47 stomach disease 10.2 ATP12A ATP4A HRH2
48 aspiration pneumonia 10.2 ATP12A ATP4A
49 peptic ulcer disease 10.2 ATP4A CYP2C19 HRH2
50 microscopic colitis 10.2 ATP12A ATP4A LYZ

Comorbidity relations with Chronic Laryngitis via Phenotypic Disease Network (PDN):


Bronchitis

Graphical network of the top 20 diseases related to Chronic Laryngitis:



Diseases related to Chronic Laryngitis

Symptoms & Phenotypes for Chronic Laryngitis

GenomeRNAi Phenotypes related to Chronic Laryngitis according to GeneCards Suite gene sharing:

26 (show all 20)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-109 9.72 GMPS
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-116 9.72 CDK9
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.72 GMPS
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-15 9.72 GMPS KRT19
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-167 9.72 GMPS
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-173 9.72 GMPS
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-200 9.72 GMPS
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-216 9.72 GMPS
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-27 9.72 CDK9
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-34 9.72 CDK9 GMPS KRT19 SLC4A1
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-40 9.72 GMPS
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 9.72 GMPS
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-55 9.72 GMPS
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 9.72 GMPS
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-65 9.72 GMPS
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-75 9.72 KRT19 SLC4A1
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 9.72 KRT19
18 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 9.72 GMPS
19 Decreased shRNA abundance (Z-score < -2) GR00366-A-86 9.72 CDK9
20 Decreased shRNA abundance (Z-score < -2) GR00366-A-98 9.72 GMPS

Drugs & Therapeutics for Chronic Laryngitis

Drugs for Chronic Laryngitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amitriptyline Approved Phase 2, Phase 3,Phase 3 50-48-6 2160
2
Perphenazine Approved Phase 2, Phase 3,Phase 3 58-39-9 4748
3 Neurotransmitter Agents Phase 2, Phase 3,Phase 3
4 Central Nervous System Depressants Phase 2, Phase 3,Phase 3
5 Peripheral Nervous System Agents Phase 2, Phase 3,Phase 3
6 Analgesics, Non-Narcotic Phase 2, Phase 3,Phase 3
7 Antidepressive Agents Phase 2, Phase 3,Phase 3
8 Amitriptyline, perphenazine drug combination Phase 2, Phase 3,Phase 3
9 Analgesics Phase 2, Phase 3,Phase 3
10 Antipsychotic Agents Phase 2, Phase 3,Phase 3
11 Antidepressive Agents, Tricyclic Phase 2, Phase 3,Phase 3
12 Psychotropic Drugs Phase 2, Phase 3,Phase 3
13 Adrenergic Agents Phase 2, Phase 3,Phase 3
14 Tranquilizing Agents Phase 2, Phase 3,Phase 3
15 Neurotransmitter Uptake Inhibitors Phase 2, Phase 3,Phase 3
16
Omeprazole Approved, Investigational, Vet_approved 73590-58-6 4594
17 Mitogens Not Applicable
18 Anti-Ulcer Agents
19 Antacids
20 Proton Pump Inhibitors
21 Gastrointestinal Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treatment of Chronic Laryngitis With Amitriptyline Suspended NCT02552225 Phase 2, Phase 3 Amitriptyline
2 Trial of the Treatment of Chronic Laryngitis With Amitryptiline Terminated NCT02434523 Phase 2, Phase 3 Amitriptyline
3 Laryngeal and Esophageal EGF-r Expression in Patients With Reflux Laryngitis Completed NCT01806220 Not Applicable
4 Salivary Epidermal Growth Factor (EGF) Concentration Before and After Treatment of Reflux Laryngitis Completed NCT01389401 omeprazole

Search NIH Clinical Center for Chronic Laryngitis

Genetic Tests for Chronic Laryngitis

Anatomical Context for Chronic Laryngitis

MalaCards organs/tissues related to Chronic Laryngitis:

41
Trachea, Skin

Publications for Chronic Laryngitis

Articles related to Chronic Laryngitis:

(show top 50) (show all 57)
# Title Authors Year
1
Korean survey data reveals an association of chronic laryngitis with tinnitus in men. ( 29324903 )
2018
2
Insulin Resistance is Associated with Chronic Laryngitis in Korean Women. ( 29582885 )
2018
3
Efficacy of acid suppression therapy in gastroesophageal reflux disease-related chronic laryngitis. ( 27749540 )
2016
4
The role of biofilm in chronic laryngitis and in head and neck cancer. ( 26371604 )
2015
5
Metabolic Syndrome and Chronic Laryngitis: The Korean National Health and Nutrition Examination Survey 2008 to 2010. ( 26512606 )
2015
6
Association between Obesity and Chronic Laryngitis in Women--Data from the Korea National Health and Nutrition Examination Survey. ( 26138994 )
2015
7
Association between Chronic Laryngitis and Particulate Matter Based on the Korea National Health and Nutrition Examination Survey 2008-2012. ( 26177353 )
2015
8
Detection of Chronic Laryngitis due to Laryngopharyngeal Reflux Using Color and Texture Analysis of Laryngoscopic Images. ( 24314831 )
2014
9
[Perceptual and automatic voice and speech analysis of chronic laryngitis and T1 vocal cord cancer]. ( 23744089 )
2013
10
Acute laryngitis superimposed on chronic laryngitis. ( 23460211 )
2013
11
An oropharyngeal pH monitoring device to evaluate patients with chronic laryngitis. ( 23495894 )
2013
12
Incidence of chronic laryngitis. ( 24592580 )
2013
13
Predictors of acid suppression success in patients with chronic laryngitis. ( 22276941 )
2012
14
Bacterial biofilm associated with chronic laryngitis. ( 22652944 )
2012
15
Comparison of patients of chronic laryngitis with and without troublesome reflux symptoms. ( 21793907 )
2012
16
Dilated intercellular space in chronic laryngitis and gastro-oesophageal reflux disease: at baseline and post-lansoprazole therapy. ( 20735783 )
2010
17
Gastroesophageal reflux-related chronic laryngitis. Commentary. ( 20855686 )
2010
18
Gastroesophageal reflux-related chronic laryngitis: con. ( 20855684 )
2010
19
GERD-related chronic laryngitis: pro. ( 20855685 )
2010
20
Benefit of acid-suppressive therapy in chronic laryngitis: the devil is in the details. ( 20621625 )
2010
21
Effect of pantoprazole in patients with chronic laryngitis and pharyngitis related to gastroesophageal reflux disease: clinical, proximal, and distal pH monitoring results. ( 20002704 )
2010
22
Salivary egf concentration in adults with reflux chronic laryngitis before and after treatment: preliminary results. ( 17589721 )
2007
23
Gastro-oesophageal reflux disease in chronic laryngitis: prevalence and response to acid-suppressive therapy. ( 17269990 )
2007
24
Chronic laryngitis associated with gastroesophageal reflux: prospective assessment of differences in practice patterns between gastroenterologists and ENT physicians. ( 16542282 )
2006
25
Proton pump inhibitor therapy for suspected GERD-related chronic laryngitis: a meta-analysis of randomized controlled trials. ( 17037995 )
2006
26
Chronic laryngitis in glassblowers. ( 15895845 )
2005
27
Improvement in clinical course and laryngeal appearance in selected patients with chronic laryngitis after eight weeks of therapy with rabeprazole. ( 15448612 )
2004
28
Severe chronic laryngitis mimicking a granulomatous disease. ( 15628624 )
2004
29
Interaction of sleep disturbances and gastroesophageal reflux in chronic laryngitis. ( 11791245 )
2002
30
Role of esophageal pH recording in management of chronic laryngitis: an overview. ( 11051423 )
2000
31
Absence of bacterial infection in the mucosal secretion in chronic laryngitis. ( 11081617 )
2000
32
Diagnosis and management of chronic laryngitis associated with reflux. ( 10718463 )
2000
33
A possible role of helicobacter pylori infection in the etiology of chronic laryngitis. ( 23119449 )
1998
34
Langerhans and other immunocompetent cells in vocal cord epithelial hyperplastic lesions of patients with chronic laryngitis. ( 9197489 )
1997
35
A possible role of Helicobacter pylori infection in the etiology of chronic laryngitis. ( 9438124 )
1997
36
[Serum dihydrotestosterone versus total testosterone values of patients with laryngeal carcinomas and chronic laryngitis]. ( 8766382 )
1996
37
Outcomes of antireflux therapy for the treatment of chronic laryngitis. ( 7598368 )
1995
38
Herpes simplex chronic laryngitis and vocal cord lesions in a patient with acquired immunodeficiency syndrome. ( 8085735 )
1994
39
The aetiology of chronic laryngitis. ( 1031354 )
1976
40
Chronic laryngitis. ( 1031346 )
1976
41
Vitamin A and chronic laryngitis. ( 4109003 )
1972
42
CHRONIC LARYNGITIS. ( 14302922 )
1965
43
The importance of chronic laryngitis. ( 13825824 )
1960
44
Contribution to treatment of chronic laryngitis in persons who use their voices professionally. ( 21024466 )
1945
45
Prominence of the Cartilages of Santorini and Wrisberg accompanied by Chronic Laryngitis. ( 19988473 )
1931
46
Slide showing Section of a Gland removed from a man with Chronic Laryngitis and an Enlarged Gland in the Neck. ( 19983734 )
1924
47
Case of Chronic Laryngitis of Long Standing. ( 19982948 )
1923
48
Chronic Laryngitis in an Unusual Form. ( 19977894 )
1914
49
Chronic Laryngitis. ( 19975088 )
1911
50
Chronic Laryngitis in a Man aged 26.? Prolapse of Ventricle on Right Side. ( 19974415 )
1910

Variations for Chronic Laryngitis

Expression for Chronic Laryngitis

Search GEO for disease gene expression data for Chronic Laryngitis.

Pathways for Chronic Laryngitis

Pathways related to Chronic Laryngitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.35 ATP4A HRH2 LYZ
2 9.32 ATP4A HRH2

GO Terms for Chronic Laryngitis

Cellular components related to Chronic Laryngitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Z disc GO:0030018 8.8 KRT19 PDLIM1 SLC4A1

Biological processes related to Chronic Laryngitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ATP hydrolysis coupled proton transport GO:0015991 9.32 ATP12A ATP4A
2 cellular sodium ion homeostasis GO:0006883 9.26 ATP12A ATP4A
3 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.16 ATP12A ATP4A
4 cellular potassium ion homeostasis GO:0030007 8.96 ATP12A ATP4A
5 sodium ion export across plasma membrane GO:0036376 8.62 ATP12A ATP4A

Molecular functions related to Chronic Laryngitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 8.96 ATP12A ATP4A
2 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP12A ATP4A

Sources for Chronic Laryngitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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