CLL
MCID: CHR418
MIFTS: 48

Chronic Leukemia (CLL)

Categories: Blood diseases, Bone diseases, Cancer diseases, Immune diseases

Aliases & Classifications for Chronic Leukemia

MalaCards integrated aliases for Chronic Leukemia:

Name: Chronic Leukemia 12 54 15 70
Adult Chronic Leukemia 12
Cll 12
Cml 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1036
NCIt 50 C3483
UMLS 70 C1279296

Summaries for Chronic Leukemia

Disease Ontology : 12 A leukemia that develops slowly.

MalaCards based summary : Chronic Leukemia, also known as adult chronic leukemia, is related to chronic neutrophilic leukemia and childhood leukemia. An important gene associated with Chronic Leukemia is STAT5A (Signal Transducer And Activator Of Transcription 5A), and among its related pathways/superpathways are Akt Signaling and Focal Adhesion. The drugs Cyclophosphamide and Prednisolone have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and myeloid, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 73 Chronic leukemia is an increase of abnormal white blood cells. It differs from acute leukemia, and is... more...

Related Diseases for Chronic Leukemia

Diseases in the Leukemia family:

Chronic Leukemia Acute Leukemia
Subacute Leukemia

Diseases related to Chronic Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 377)
# Related Disease Score Top Affiliating Genes
1 chronic neutrophilic leukemia 31.9 U2AF1 LUC7L2 ASXL1
2 childhood leukemia 31.9 STAT5B STAT5A BCR
3 leukemia, chronic lymphocytic 31.8 XIAP U2AF1 STAT3 PTEN H2AC18 CCND1
4 leukemia 31.7 WT1 U2AF1 STAT3 CCND1 BCR ASXL1
5 chronic myelomonocytic leukemia 31.7 U2AF1 STAT5A LUC7L2 ASXL1
6 chronic eosinophilic leukemia 31.5 WT1 U2AF1 STAT5B STAT5A FIP1L1 ASXL1
7 juvenile myelomonocytic leukemia 31.5 U2AF1 STAT5A STAT3 PTEN LUC7L2 ASXL1
8 leukemia, chronic myeloid 31.5 WT1 U2AF1 STAT5B STAT5A PRAME LUC7L2
9 acute leukemia 30.8 WT1 PRAME DIABLO BCR
10 myeloid leukemia 30.7 WT1 U2AF1 STAT5B STAT5A STAT3 BCR
11 lymphoma, non-hodgkin, familial 30.6 XIAP U2AF1 STAT3 H2AC18 CCND1 BCR
12 t-cell lymphoblastic leukemia/lymphoma 30.6 XIAP STAT5A STAT3 CCND1
13 peripheral t-cell lymphoma 30.3 STAT5A STAT3 PTEN CCND1
14 monoclonal gammopathy of uncertain significance 30.3 U2AF1 LUC7L2 CCND1
15 polycythemia vera 30.1 U2AF1 STAT5B STAT5A STAT3 FIP1L1 ASXL1
16 t-cell acute lymphoblastic leukemia 30.1 XIAP U2AF1 STAT5B STAT5A PTEN
17 myelodysplastic syndrome 30.1 XIAP WT1 U2AF1 STAT5B STAT5A STAT3
18 indolent systemic mastocytosis 30.0 U2AF1 FIP1L1 ASXL1
19 atypical chronic myeloid leukemia 30.0 U2AF1 LUC7L2 ASXL1
20 myeloma, multiple 29.9 XIAP U2AF1 STAT3 PTEN H2AC18 CCND1
21 systemic mastocytosis 29.9 STAT5B STAT5A FIP1L1 ASXL1
22 mastocytosis 29.9 STAT5B STAT5A FIP1L1 ASXL1
23 leukemia, acute lymphoblastic 29.9 XIAP WT1 U2AF1 STAT5B STAT5A PTEN
24 pancytopenia 29.9 XIAP U2AF1 LUC7L2 H2AC18
25 gastrointestinal stromal tumor 29.9 WT1 PTGS2 PTEN CCND1
26 myelofibrosis 29.7 WT1 U2AF1 STAT5B STAT5A STAT3 ASXL1
27 peripheral nervous system disease 29.7 U2AF1 STAT3 PTGS2 PTEN H2AC18 CCND1
28 essential thrombocythemia 29.6 U2AF1 STAT5B STAT5A STAT3 CCND1 BCR
29 myeloproliferative neoplasm 29.6 WT1 U2AF1 STAT5B STAT5A STAT3 FIP1L1
30 hematologic cancer 29.6 XIAP WT1 U2AF1 STAT5B STAT5A PRAME
31 aplastic anemia 29.5 WT1 U2AF1 STAT3 LUC7L2 H2AC18 GFI1B
32 acute promyelocytic leukemia 29.4 XIAP WT1 STAT5B STAT5A STAT3 PTEN
33 leukemia, acute myeloid 29.1 XIAP WT1 U2AF1 STAT5B STAT5A STAT3
34 cll/sll 11.2
35 postgerminal center chronic lymphocytic leukemia/small lymphocytic lymphoma 10.9
36 pregerminal center chronic lymphocytic leukemia/small lymphocytic lymphoma 10.9
37 subacute leukemia 10.9
38 b-cell lymphoma 10.6
39 lymphoma 10.6
40 neutropenia 10.5
41 glioblastoma neural subtype 10.5 STAT5B STAT5A
42 microcystic stromal tumor 10.5 WT1 CCND1
43 bowenoid papulosis 10.4 PTGS2 CCND1
44 leukemia, chronic lymphocytic 2 10.4
45 diffuse large b-cell lymphoma 10.4
46 jak3-deficient severe combined immunodeficiency 10.4 STAT5B STAT5A
47 lymphoma, hodgkin, classic 10.4
48 thrombocytopenia 10.4
49 peritoneum cancer 10.4 WT1 PTEN H2AC18
50 respiratory system benign neoplasm 10.4 PTEN H2AC18 CCND1

Comorbidity relations with Chronic Leukemia via Phenotypic Disease Network (PDN):


Acute Cystitis Leukemia, Chronic Lymphocytic

Graphical network of the top 20 diseases related to Chronic Leukemia:



Diseases related to Chronic Leukemia

Symptoms & Phenotypes for Chronic Leukemia

GenomeRNAi Phenotypes related to Chronic Leukemia according to GeneCards Suite gene sharing:

26 (show all 13)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-1 9.75 BCR
2 Decreased viability GR00055-A-2 9.75 BCR
3 Decreased viability GR00106-A-0 9.75 FIP1L1 U2AF1
4 Decreased viability GR00221-A-1 9.75 HGF
5 Decreased viability GR00221-A-2 9.75 BCR HGF
6 Decreased viability GR00221-A-4 9.75 BCR HGF
7 Decreased viability GR00249-S 9.75 BCR CCND1 FIP1L1 FSTL3 GFI1B
8 Decreased viability GR00301-A 9.75 BCR
9 Decreased viability GR00342-S-3 9.75 BCR
10 Decreased viability GR00381-A-1 9.75 DIABLO WT1
11 Decreased viability GR00386-A-1 9.75 FIP1L1 GFI1B LUC7L2 PTEN
12 Decreased viability GR00402-S-2 9.75 BCR CCND1 DIABLO GFI1B U2AF1
13 Decreased sensitivity to paclitaxel GR00112-A-0 8.96 PTEN WT1

MGI Mouse Phenotypes related to Chronic Leukemia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.29 ASXL1 BCR CCND1 DIABLO GFI1B HGF
2 growth/size/body region MP:0005378 10.25 ASXL1 BCR CCND1 DIABLO FSTL3 HGF
3 hematopoietic system MP:0005397 10.22 ASXL1 BCR CCND1 GFI1B HGF PTEN
4 endocrine/exocrine gland MP:0005379 10.2 ASXL1 CCND1 FSTL3 PTEN PTGS2 SOAT1
5 homeostasis/metabolism MP:0005376 10.18 ASXL1 BCR CCND1 FSTL3 GFI1B PTEN
6 immune system MP:0005387 10.1 ASXL1 BCR CCND1 GFI1B PTEN PTGS2
7 integument MP:0010771 9.91 CCND1 GFI1B PTEN PTGS2 SOAT1 STAT3
8 liver/biliary system MP:0005370 9.9 ASXL1 BCR FSTL3 HGF PTEN PTGS2
9 neoplasm MP:0002006 9.5 ASXL1 CCND1 PTEN PTGS2 SOAT1 STAT3
10 normal MP:0002873 9.32 BCR CCND1 DIABLO PTEN PTGS2 STAT3

Drugs & Therapeutics for Chronic Leukemia

Drugs for Chronic Leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 33)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyclophosphamide Approved, Investigational Phase 2, Phase 3 50-18-0, 6055-19-2 2907
2
Prednisolone Approved, Vet_approved Phase 2, Phase 3 50-24-8 5755
3
Methylprednisolone Approved, Vet_approved Phase 2, Phase 3 83-43-2 6741
4
Fludarabine Approved Phase 2, Phase 3 21679-14-1, 75607-67-9 30751
5
Prednisolone phosphate Approved, Vet_approved Phase 2, Phase 3 302-25-0
6
Methylprednisolone hemisuccinate Approved Phase 2, Phase 3 2921-57-5
7
Lenograstim Approved, Investigational Phase 2, Phase 3 135968-09-1
8
Tacrolimus Approved, Investigational Phase 2, Phase 3 104987-11-3 6473866 445643 439492
9
Prednisolone acetate Approved, Vet_approved Phase 2, Phase 3 52-21-1
10
Prednisolone hemisuccinate Experimental Phase 2, Phase 3 2920-86-7
11 Alkylating Agents Phase 2, Phase 3
12 Immunosuppressive Agents Phase 2, Phase 3
13 Immunologic Factors Phase 2, Phase 3
14 Antirheumatic Agents Phase 2, Phase 3
15 Antilymphocyte Serum Phase 2, Phase 3
16 Gastrointestinal Agents Phase 2, Phase 3
17 Neuroprotective Agents Phase 2, Phase 3
18 Antiemetics Phase 2, Phase 3
19 Methylprednisolone Acetate Phase 2, Phase 3
20 Hormones Phase 2, Phase 3
21 glucocorticoids Phase 2, Phase 3
22 Hormone Antagonists Phase 2, Phase 3
23 Antimetabolites Phase 2, Phase 3
24 Calcineurin Inhibitors Phase 2, Phase 3
25 Anti-Inflammatory Agents Phase 2, Phase 3
26 Protective Agents Phase 2, Phase 3
27 Imatinib Mesylate Phase 3 220127-57-1 123596
28 Protein Kinase Inhibitors Phase 3
29
Busulfan Approved, Investigational Phase 2 55-98-1 2478
30
Cytarabine Approved, Investigational Phase 2 147-94-4 6253
31 Anti-Infective Agents Phase 2
32 Antiviral Agents Phase 2
33
Tyrosine Approved, Investigational, Nutraceutical 60-18-4 6057

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase III Multi-center, Open-label, Randomized Study of Imatinib Versus Nilotinib in Adult Patients With Newly Diagnosed Philadelphia Chromosome Positive (Ph+) Chronic Myelogenous Leukemia in Chronic Phase (CML-CP) Completed NCT00471497 Phase 3 nilotinib;imatinib
2 A Multi-Center, Open Label, Randomized, Active Controlled Phase II/III Clinical Trial to Evaluate the Safety and Efficacy of Processed Unrelated Bone Marrow in Patients With Acute or Chronic Leukemia Completed NCT00004255 Phase 2, Phase 3 cyclophosphamide;fludarabine phosphate;methylprednisolone;tacrolimus
3 A Phase III Randomized, Open- Label Multi-center Study of Nilotinib Versus Imatinib in Adult Patients With Ph+ Chronic Myelogenous Leukemia in Chronic Phase (CML-CP) Who Have a Suboptimal Cytogenetic Response (CyR) on Imatinib Terminated NCT00519090 Phase 3 Imatinib;Nilotinib (AMN107)
4 A Pilot Trial of OSI-461 in Patients With Chronic Lymphocytic Leukemia Completed NCT00073489 Phase 2 OSI-461
5 A Phase II Trial of Total Body Irradiation-Based Myeloablative Conditioning and Transplantation of Partially HLA-Mismatched Peripheral Blood Stem Cells for Patients With Hematologic Malignancies Completed NCT01336712 Phase 2
6 BUSULFAN AND CYCLOPHOSPHAMIDE FOR CYTOREDUCTION OF PATIENTS WITH ACUTE AND CHRONIC LEUKEMIAS AND MYELODYSPLASTIC SYNDROMES UNDERGOING ALLOGENEIC BONE MARROW TRANSPLANTATION WHO CANNOT BE TREATED WITH TOTAL BODY IRRADIATION Completed NCT00002502 Phase 2 busulfan;cyclophosphamide;cytarabine
7 Study of Predictive Immunological Parameters of Molecular Complete Remission in Patients With Chronic Myelogenous Leukemia in Chronic Phase and Treated With Tyrosine Kinase Inhibitor Unknown status NCT02842333
8 A Pilot/Observational Study Using a Biomarker Monitoring System to Evaluate Protein Profiles of Neutropenic Fever/Infection in Patients With Acute or Chronic Leukemias Undergoing Chemotherapy or Other Biologic Treatment Completed NCT01144793
9 Evaluating the Effect of a Digital Coaching Program on Self-Efficacy and Patient Reported Outcomes of Individuals With Acute and Chronic Leukemia Recruiting NCT04774744
10 Allogeneic Transplant for Hematological Malignancy Terminated NCT00176930 Cyclophosphamide;Busulfan;Equine ATG (ATGAM)

Search NIH Clinical Center for Chronic Leukemia

Genetic Tests for Chronic Leukemia

Anatomical Context for Chronic Leukemia

MalaCards organs/tissues related to Chronic Leukemia:

40
Bone, Bone Marrow, Myeloid, Liver, Spleen, T Cells, B Cells

Publications for Chronic Leukemia

Articles related to Chronic Leukemia:

(show top 50) (show all 821)
# Title Authors PMID Year
1
[Specific function of STAT5 in regulation of proliferation of chronic leukemia K562 cells: inhibitory effect of WHI-P131]. 54 61
20352702 2010
2
Expression of the MDR1 and MDR3 gene products in acute and chronic leukemias. 61 54
9150348 1997
3
Expression of the multidrug resistance-associated protein (MRP) in acute and chronic leukemias. 54 61
7911548 1994
4
Differences between blastic chronic myeloid leukemia and Ph-positive acute leukemia. 54 61
8251902 1993
5
Cytogenetic and molecular changes in leukemia found among atomic bomb survivors. 54 61
1762103 1991
6
High-throughput liquid chromatography/electrospray ionization tandem mass spectrometry method using in-source collision-induced dissociation for simultaneous quantification of imatinib, dasatinib, bosutinib, nilotinib, and ibrutinib in human plasma. 61
33772839 2021
7
Targeting RNA-binding proteins in acute and chronic leukemia. 61
33149266 2021
8
Dysregulation of oncogenic factors by GFI1B p32: investigation of a novel GFI1B germline mutation. 61
33472357 2021
9
[Synergistic role of JAK/STAT5 and PI3K/AKT signaling pathways in regulating eIF4B in acute leukemia]. 61
33244935 2020
10
Genetic Variation of Costimulatory Molecules, Including Cytotoxic T-Lymphocyte Antigen 4, Inducible T-Cell Costimulator, Cluster Differentiation 28, and Programmed Cell Death 1 Genes, in Iranian Patients With Leukemia. 61
29697355 2020
11
Hematological malignancies in Ukraine in post-Chernobyl era: sources of data and their preliminary analysis. 61
32430702 2020
12
Hematological malignancies in relation with ABO blood group at a teaching hospital, Varanasi, India. 61
32754493 2020
13
Associations between genetic polymorphisms in interleukin-10 and hematological oncology: evidence from a meta-analysis. 61
31910710 2020
14
IoMT-Based Automated Detection and Classification of Leukemia Using Deep Learning. 61
33343851 2020
15
Genetic and epigenetic factors interacting with clonal hematopoiesis resulting in chronic myelomonocytic leukemia. 61
31688455 2020
16
A sudden bilateral hearing loss caused by inner ear hemorrhage. 61
31178427 2020
17
Chemoenzymatic Synthesis of Enantiomeric, Bicyclic δ-Halo-γ-lactones with a Cyclohexane Ring, Their Biological Activity and Interaction with Biological Membranes. 61
31935977 2020
18
Targeted blocking of miR328 lysosomal degradation with alkalized exosomes sensitizes the chronic leukemia cells to imatinib. 61
31701195 2019
19
Sensor array based on single carbon quantum dot for fluorometric differentiation of all natural amino acids. 61
31784824 2019
20
MicroRNA in leukemia: Tumor suppressors and oncogenes with prognostic potential. 61
30515779 2019
21
Signaling pathways involved in chronic myeloid leukemia pathogenesis: The importance of targeting Musashi2-Numb signaling to eradicate leukemia stem cells. 61
31231484 2019
22
Effects of GST null genotypes on individual susceptibility to leukemia: A meta-analysis. 61
30659796 2019
23
THE FORECAST OF LETHAL OUTCOME IN CHRONIC LEUKEMIA PATIENTS WITH PNEUMONIA. 61
31101784 2019
24
Disparities in place of death for patients with hematological malignancies, 1999 to 2015. 61
30709864 2019
25
Evolution of survivorship in lymphoma, myeloma and leukemia: Metamorphosis of the field into long term follow-up care. 61
30093158 2019
26
Potential Leukemic Cells Engraftment After Hematopoietic Stem Cell Transplantation From Unrelated Donors With Undiagnosed Chronic Leukemia. 61
30509616 2018
27
Effects of GST variants on the risk odds of hematological malignancy: A meta-analysis. 61
30537151 2018
28
Extranodal Richter's syndrome of the urinary bladder. 61
30337788 2018
29
Safety and Outcome of Percutaneous Drainage of Pericardial Effusions in Patients with Cancer. 61
30064854 2018
30
Pemphigus and hematologic malignancies: A population-based study of 11,859 patients. 61
29198780 2018
31
Expression of aberrant antigens in hematological malignancies: A single center experience. 61
29805426 2018
32
MiR-130a is aberrantly overexpressed in adult acute myeloid leukemia with t(8;21) and its suppression induces AML cell death. 61
29493383 2018
33
Targeted drug delivery for tumor therapy inside the bone marrow. 61
29182960 2018
34
Cancer in Kenya: types and infection-attributable. Data from the adult population of two National referral hospitals (2008-2012). 61
32382698 2018
35
Ocular Manifestations in Leukemias and Their Correlation with Hematologic Parameters at a Tertiary Care Setting in South India. 61
31047297 2018
36
[Molecular markers of the oral mucosa damage in patients with leukemia.] 61
30702225 2018
37
Therapeutic targeting of CK2 in acute and chronic leukemias. 61
28951560 2018
38
Purification of polysaccharide from artificially cultivated Anoectochilus roxburghii (wall.) Lindl. by high-speed counter current chromatography and its antitumor activity. 61
28892307 2017
39
Survivorship and the chronic cancer patient: Patterns in treatment-related effects, follow-up care, and use of survivorship care plans. 61
28654153 2017
40
[Clinical Application Value of Peripheral Blood Diagnostic Report]. 61
29061005 2017
41
GTF2I Mutations Are Common in Thymic Epithelial Tumors But Not in Hematological Malignancies. 61
28982856 2017
42
Alternative Donor Graft Sources for Adults with Hematologic Malignancies: A Donor for All Patients in 2017! 61
28546462 2017
43
Exposure-Response Analysis of Alvocidib (Flavopiridol) Treatment by Bolus or Hybrid Administration in Newly Diagnosed or Relapsed/Refractory Acute Leukemia Patients. 61
28174232 2017
44
Indwelling Pleural Catheters for Patients with Hematologic Malignancies. A 14-Year, Single-Center Experience. 61
28326798 2017
45
Pulmonary Manifestations of Lymphoma and Leukemia. 61
28477632 2017
46
Atypical chronic myeloid leukemia in a German Shepherd Dog. 61
28205462 2017
47
Differential Expression of Circadian Genes in Leukemia and a Possible Role for Sirt1 in Restoring the Circadian Clock in Chronic Myeloid Leukemia. 61
30210557 2017
48
Correlation of Cadmium and Magnesium in the Blood and Serum Samples of Smokers and Non-Smokers Chronic Leukemia Patients. 61
27511371 2017
49
Higher dose of CD34+ peripheral blood stem cells is associated with better survival after haploidentical stem cell transplantation in pediatric patients. 61
27888540 2017
50
Noninvasive Ventilation in Patients With Hematologic Malignancy. 61
28142306 2017

Variations for Chronic Leukemia

Expression for Chronic Leukemia

Search GEO for disease gene expression data for Chronic Leukemia.

Pathways for Chronic Leukemia

Pathways related to Chronic Leukemia according to GeneCards Suite gene sharing:

(show all 42)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.38 XIAP STAT5B STAT5A STAT3 PTEN HGF
2
Show member pathways
12.86 XIAP STAT3 PTGS2 PTEN HGF CCND1
3
Show member pathways
12.82 STAT5B STAT5A STAT3 PTEN CCND1 BCR
4
Show member pathways
12.74 STAT5B STAT5A STAT3 PTEN CCND1
5
Show member pathways
12.68 XIAP STAT3 PTGS2 PTEN HGF
6
Show member pathways
12.54 STAT5B STAT5A STAT3 PTEN HGF CCND1
7
Show member pathways
12.47 STAT5B STAT5A STAT3 PTEN HGF CCND1
8
Show member pathways
12.44 STAT5B STAT5A STAT3 PTEN CCND1
9
Show member pathways
12.38 STAT5B STAT5A STAT3 CCND1
10 12.36 STAT5B STAT5A STAT3 PTGS2 PRAME GFI1B
11
Show member pathways
12.32 STAT5B STAT5A STAT3 PTEN CCND1
12 12.27 STAT5B STAT5A STAT3 CCND1
13 12.22 XIAP STAT5B STAT5A PTEN CCND1
14 12.15 STAT5B STAT5A STAT3 PTEN
15
Show member pathways
12.14 STAT5B STAT5A STAT3 PTEN
16
Show member pathways
12.12 STAT5B STAT5A STAT3 BCR
17
Show member pathways
12.03 XIAP STAT5B STAT5A STAT3 H2AC18
18 12 XIAP STAT5B STAT5A STAT3 PTGS2 PTEN
19 11.93 STAT3 PTGS2 HGF CCND1
20 11.86 STAT5B STAT5A STAT3 CCND1
21 11.85 STAT5B STAT5A STAT3 CCND1
22
Show member pathways
11.82 STAT5B STAT5A STAT3
23 11.82 STAT3 PTEN CCND1
24
Show member pathways
11.81 XIAP STAT5B STAT5A STAT3
25 11.78 XIAP PTGS2 PTEN CCND1
26
Show member pathways
11.75 STAT5B STAT5A STAT3 BCR
27
Show member pathways
11.73 STAT5B STAT5A STAT3
28 11.73 STAT5B STAT5A STAT3
29 11.7 STAT5B STAT5A STAT3
30 11.66 STAT5B STAT5A STAT3
31 11.56 XIAP PTEN CCND1
32 11.53 STAT3 PTGS2 CCND1
33 11.52 STAT5B STAT5A STAT3
34 11.48 STAT5B STAT5A STAT3
35
Show member pathways
11.41 STAT5B STAT5A STAT3
36 11.36 STAT5B STAT5A STAT3
37 11.36 STAT5B STAT5A STAT3 PTEN
38
Show member pathways
11.21 STAT5B STAT5A STAT3
39
Show member pathways
11.2 STAT5B STAT5A STAT3 CCND1
40 11.18 STAT5B STAT5A HGF
41
Show member pathways
11.08 STAT5B STAT5A STAT3 HGF
42 10.54 STAT5B STAT5A STAT3 CCND1

GO Terms for Chronic Leukemia

Cellular components related to Chronic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.86 XIAP WT1 U2AF1 STAT5B STAT5A STAT3
2 nucleoplasm GO:0005654 9.47 XIAP WT1 U2AF1 STAT5B STAT5A STAT3

Biological processes related to Chronic Leukemia according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.11 WT1 STAT5B STAT3 HGF GFI1B FSTL3
2 positive regulation of cell proliferation GO:0008284 9.99 STAT5B STAT3 PTGS2 PTEN PRAME CCND1
3 regulation of cell cycle GO:0051726 9.84 XIAP STAT3 PTEN CCND1
4 response to organic cyclic compound GO:0014070 9.83 STAT3 PTGS2 PTEN CCND1
5 regulation of cell proliferation GO:0042127 9.8 XIAP STAT5B STAT5A STAT3 PTGS2
6 negative regulation of apoptotic process GO:0043066 9.8 XIAP WT1 STAT5B PTGS2 PTEN PRAME
7 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 9.76 XIAP PTGS2 HGF
8 response to peptide hormone GO:0043434 9.75 STAT5B STAT5A STAT3
9 response to organic substance GO:0010033 9.73 STAT3 PTGS2 PTEN CCND1
10 lactation GO:0007595 9.72 STAT5B STAT5A CCND1
11 JAK-STAT cascade GO:0007259 9.67 STAT5B STAT5A STAT3
12 interleukin-7-mediated signaling pathway GO:0038111 9.65 STAT5B STAT5A STAT3
13 regulation of multicellular organism growth GO:0040014 9.63 STAT5B STAT5A STAT3
14 cytokine-mediated signaling pathway GO:0019221 9.63 STAT5B STAT5A STAT3 PTGS2 HGF CCND1
15 regulation of BMP signaling pathway GO:0030510 9.61 XIAP FSTL3
16 interleukin-2-mediated signaling pathway GO:0038110 9.61 STAT5B STAT5A
17 response to leptin GO:0044321 9.6 STAT3 CCND1
18 cellular response to leptin stimulus GO:0044320 9.59 STAT3 PTEN
19 taurine metabolic process GO:0019530 9.56 STAT5B STAT5A
20 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 9.54 STAT5B STAT5A STAT3
21 interleukin-15-mediated signaling pathway GO:0035723 9.5 STAT5B STAT5A STAT3
22 interleukin-9-mediated signaling pathway GO:0038113 9.13 STAT5B STAT5A STAT3
23 response to estradiol GO:0032355 9.02 STAT5B STAT3 PTGS2 PTEN CCND1

Molecular functions related to Chronic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.62 XIAP WT1 U2AF1 STAT5B STAT5A STAT3
2 enzyme binding GO:0019899 9.35 PTGS2 PTEN LUC7L2 CCND1 BCR
3 glucocorticoid receptor binding GO:0035259 9.16 STAT5B STAT3

Sources for Chronic Leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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