MCID: CHR284
MIFTS: 19

Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids

Categories: Immune diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Chronic Lymphocytic Inflammation with Pontine Perivascular...

MalaCards integrated aliases for Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids:

Name: Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids 53 59
Clippers 53 59

Characteristics:

Orphanet epidemiological data:

59
clippers
Inheritance: Not applicable; Prevalence: <1/1000000 (Worldwide); Age of onset: Adult;

Classifications:

Orphanet: 59  
Rare neurological diseases


External Ids:

Orphanet 59 ORPHA284448
UMLS via Orphanet 74 C3854437

Summaries for Chronic Lymphocytic Inflammation with Pontine Perivascular...

NIH Rare Diseases : 53 Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) is a treatable inflammatory disease of the central nervous system. Specifically, it is a type of encephalomyelitis, which is a general term describing inflammation of the brain and spinal cord. CLIPPERS predominantly affects the cerebellum, spinal cord, and brainstem - the part of the brain that directly connects to the spinal cord. Symptoms usually develop over weeks or months, and only rarely over days. The most common symptoms of CLIPPERS include uncoordinated walking (gait ataxia), double vision (diplopia), difficulty speaking (dysarthria), cognitive impairment, and abnormal facial sensations (such as numbness or tingling). Other symptoms may include pseudobulbar affect, ringing in the ears (tinnitis), shaking muscles (tremor), uncontrolled eye movements (nystagmus), distortion of taste, nausea, or paraparesis (partial loss of function of the legs).  The underlying cause of CLIPPERS currently is unclear. There is no one laboratory or imaging test that confirms the diagnosis, but various laboratory and imaging tests may be needed to support the diagnosis, and to confirm or rule out many other conditions that cause overlapping symptoms. A brain MRI with contrast typically has characteristic findings. An important part of the ultimate diagnosis, and a classic feature of CLIPPERS, is that symptoms and MRI findings markedly improve with corticosteroid therapy. Corticosteroids may first be taken intravenously (by IV) for several days, and then orally. Most people with CLIPPERS recover significantly within weeks of starting corticosteroids. However, depending on symptom severity and how long the disease was present before treatment, some people will not recover completely. Prolonged treatment with corticosteroids or other immunosuppressant medications (for at least one year) usually is necessary to prevent symptoms from recurring or worsening again.

MalaCards based summary : Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids, also known as clippers, is related to hepatitis and hepatitis b. Affiliated tissues include testes, brain and eye.

Related Diseases for Chronic Lymphocytic Inflammation with Pontine Perivascular...

Diseases related to Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 hepatitis 10.3
2 hepatitis b 10.3
3 lymphomatoid granulomatosis 10.3
4 lymphoma 10.3
5 neuropathy 10.3
6 viral infectious disease 10.3
7 encephalitis 10.3
8 limbic encephalitis 10.3
9 seizure disorder 10.3
10 headache 10.3

Graphical network of the top 20 diseases related to Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids:



Diseases related to Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids

Symptoms & Phenotypes for Chronic Lymphocytic Inflammation with Pontine Perivascular...

Drugs & Therapeutics for Chronic Lymphocytic Inflammation with Pontine Perivascular...

Search Clinical Trials , NIH Clinical Center for Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids

Genetic Tests for Chronic Lymphocytic Inflammation with Pontine Perivascular...

Anatomical Context for Chronic Lymphocytic Inflammation with Pontine Perivascular...

MalaCards organs/tissues related to Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids:

41
Testes, Brain, Eye, Spinal Cord, Cerebellum, B Cells

Publications for Chronic Lymphocytic Inflammation with Pontine Perivascular...

Articles related to Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids:

(show top 50) (show all 81)
# Title Authors Year
1
CLIPPERS mimickers: relapsing brainstem encephalitis associated with anti-MOG antibodies. ( 29356261 )
2018
2
Occipital Headache in Chronic Lymphocytic Inflammation With Pontine Perivascular Enhancement Responsive to Steroids (CLIPPERS). ( 29193048 )
2018
3
Case 259: Primary Central Nervous System Lymphomatoid Granulomatosis Mimicking Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids (CLIPPERS). ( 30332362 )
2018
4
Isolated painful trigeminal neuropathy as an unusual presentation of chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids: A case report. ( 29863408 )
2018
5
Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids with seizures and central pyrexia, in a patient requiring tracheal intubation and mechanical ventilation: A case report. ( 29796076 )
2018
6
CLIPPERS, a possible symptomatic lymphohistiocytic immune reaction. ( 29161338 )
2018
7
Reply: CLIPPERS, a possible symptomatic lymphohistiocytic immune reaction. ( 29161360 )
2018
8
Reply: A case of CLIPPERS challenging the new diagnostic criteria. ( 29244097 )
2018
9
A case of CLIPPERS challenging the new diagnostic criteria. ( 29253092 )
2018
10
CLIPPERS: Cutaneous manifestations. ( 29291480 )
2018
11
Effective treatment of CLIPPERS with long-term use of rituximab. ( 29511706 )
2018
12
Blood and virus detection on barber clippers. ( 29629677 )
2018
13
Omics-Based Approach Reveals Complement-Mediated Inflammation in Chronic Lymphocytic Inflammation With Pontine Perivascular Enhancement Responsive to Steroids (CLIPPERS). ( 29740431 )
2018
14
Is chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) in children the same condition as in adults? ( 30146710 )
2018
15
CLIPPERS syndrome responsive to Leflunomide: A case report. ( 30149302 )
2018
16
Two cases of CLIPPERS with increased number of perivascular CD20-positive B lymphocytes. ( 30202949 )
2018
17
Reply: Two cases of CLIPPERS with increased number of perivascular CD20-positive B lymphocytes. ( 30203037 )
2018
18
Growing the phenotype of chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) in children. ( 30246371 )
2018
19
CLIPPERS: An Increasingly Recognized Chronic Inflammatory Central Nervous System Disorder. ( 30367853 )
2018
20
Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids (CLIPPERS) with Limbic Encephalitis. ( 28824066 )
2017
21
Comparison of neural histomorphology in tail tips from pigs docked using clippers or cautery iron. ( 27903311 )
2017
22
CLIPPERS and the need for long-term immunosuppression. ( 28110629 )
2017
23
Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS): A lymphocytic reactive response of the central nervous system? A case report. ( 28284348 )
2017
24
Therapeutic Approaches in CLIPPERS. ( 28386850 )
2017
25
Electroencephalographic responses of anaesthetized pigs (Sus scrofa) to tail docking using clippers or cautery iron performed at 2 or 20 days of age. ( 28412163 )
2017
26
CLIPPERS. ( 28726127 )
2017
27
Diagnostic criteria for chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS). ( 29050399 )
2017
28
Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS): A pediatric case report with six year follow-up. ( 29055484 )
2017
29
Poster 330 Rehabilitation of a Patient with Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids (CLIPPERS) Syndrome: A Case Report. ( 27673085 )
2016
30
Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) with intracranial Epstein-Barr virus infection: A Case Report. ( 27861371 )
2016
31
A Rare Cause of Dizziness and Gait Ataxia: CLIPPERS Syndrome. ( 30151443 )
2016
32
Chronic hepatitis B infection presenting with chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS): a case report. ( 26582039 )
2015
33
Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS): postmortem findings. ( 25575138 )
2015
34
Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) after treatment for Hodgkin's lymphoma. ( 26243623 )
2015
35
MRI evolution of CLIPPERS syndrome following herpes zoster infection. ( 25432545 )
2015
36
A Case Report of CLIPPERS (Chronic Lymphocytic Inflammation with Pontocerebellar Perivascular Enhancement Responsive to Steroids) Syndrome. ( 24068102 )
2015
37
Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS): A case report and review of literature. ( 26425017 )
2015
38
Movement disorders associated with CLIPPERS. ( 24222187 )
2014
39
CLIPPERS with chronic small vessel damage: more overlap with small vessel vasculitis? ( 24487801 )
2014
40
Homing endonucleases: from genetic anomalies to programmable genomic clippers. ( 24510256 )
2014
41
CLIPPERS and its related disorders, relevance of brain 3.0 T MR. ( 24556501 )
2014
42
Supramolecular clippers for controlling photophysical processes through preorganized chromophores. ( 24623564 )
2014
43
Emergence of Primary CNS Lymphoma in a Patient with Findings of CLIPPERS. ( 24878484 )
2014
44
CLIPPERS among patients diagnosed with non-specific CNS neuroinflammatory diseases. ( 24954086 )
2014
45
Response regarding CLIPPERS. ( 24979349 )
2014
46
A central nervous system B-cell lymphoma arising two years after initial diagnosis of CLIPPERS. ( 24990651 )
2014
47
Effective antituberculous therapy in a patient with CLIPPERS: New insights into CLIPPERS pathogenesis. ( 25340062 )
2014
48
CLIPPERS: chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids. Review of an increasingly recognized entity within the spectrum of inflammatory central nervous system disorders. ( 24028073 )
2014
49
Should CLIPPERS be considered a Prelymphoma state or a new Inflammatory disease? ( 24030207 )
2013
50
Should CLIPPERS be considered a Prelymphoma state or a new Inflammatory disease. ( 24030209 )
2013

Variations for Chronic Lymphocytic Inflammation with Pontine Perivascular...

Expression for Chronic Lymphocytic Inflammation with Pontine Perivascular...

Search GEO for disease gene expression data for Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids.

Pathways for Chronic Lymphocytic Inflammation with Pontine Perivascular...

GO Terms for Chronic Lymphocytic Inflammation with Pontine Perivascular...

Sources for Chronic Lymphocytic Inflammation with Pontine Perivascular...

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....