MCID: CHR284
MIFTS: 20

Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids

Categories: Immune diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Chronic Lymphocytic Inflammation with Pontine Perivascular...

MalaCards integrated aliases for Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids:

Name: Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids 54 60
Clippers 54 60

Characteristics:

Orphanet epidemiological data:

60
clippers
Inheritance: Not applicable; Prevalence: <1/1000000 (Worldwide); Age of onset: Adult;

Classifications:

Orphanet: 60  
Rare neurological diseases


External Ids:

UMLS via Orphanet 75 C3854437
Orphanet 60 ORPHA284448

Summaries for Chronic Lymphocytic Inflammation with Pontine Perivascular...

NIH Rare Diseases : 54 Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) is a treatable inflammatory disease of the central nervous system. Specifically, it is a type of encephalomyelitis, which is a general term describing inflammation of the brain and spinal cord. CLIPPERS predominantly affects the cerebellum, spinal cord, and brainstem - the part of the brain that directly connects to the spinal cord. Symptoms usually develop over weeks or months, and only rarely over days. The most common symptoms of CLIPPERS include uncoordinated walking (gait ataxia), double vision (diplopia), difficulty speaking (dysarthria), cognitive impairment, and abnormal facial sensations (such as numbness or tingling). Other symptoms may include pseudobulbar affect, ringing in the ears (tinnitis), shaking muscles (tremor), uncontrolled eye movements (nystagmus), distortion of taste, nausea, or paraparesis (partial loss of function of the legs).  The underlying cause of CLIPPERS currently is unclear. There is no one laboratory or imaging test that confirms the diagnosis, but various laboratory and imaging tests may be needed to support the diagnosis, and to confirm or rule out many other conditions that cause overlapping symptoms. A brain MRI with contrast typically has characteristic findings. An important part of the ultimate diagnosis, and a classic feature of CLIPPERS, is that symptoms and MRI findings markedly improve with corticosteroid therapy. Corticosteroids may first be taken intravenously (by IV) for several days, and then orally. Most people with CLIPPERS recover significantly within weeks of starting corticosteroids. However, depending on symptom severity and how long the disease was present before treatment, some people will not recover completely. Prolonged treatment with corticosteroids or other immunosuppressant medications (for at least one year) usually is necessary to prevent symptoms from recurring or worsening again.

MalaCards based summary : Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids, also known as clippers, is related to lymphoma and hepatitis. Affiliated tissues include testes, brain and spinal cord.

Related Diseases for Chronic Lymphocytic Inflammation with Pontine Perivascular...

Diseases related to Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 12)
# Related Disease Score Top Affiliating Genes
1 lymphoma 10.5
2 hepatitis 10.3
3 hepatitis b 10.3
4 lymphomatoid granulomatosis 10.3
5 central nervous system lymphoma 10.3
6 neuropathy 10.3
7 encephalitis 10.3
8 cutaneous sclerosis 10.3
9 limbic encephalitis 10.3
10 primary central nervous system lymphoma 10.3
11 seizure disorder 10.3
12 headache 10.3

Graphical network of the top 20 diseases related to Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids:



Diseases related to Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids

Symptoms & Phenotypes for Chronic Lymphocytic Inflammation with Pontine Perivascular...

Drugs & Therapeutics for Chronic Lymphocytic Inflammation with Pontine Perivascular...

Search Clinical Trials , NIH Clinical Center for Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids

Genetic Tests for Chronic Lymphocytic Inflammation with Pontine Perivascular...

Anatomical Context for Chronic Lymphocytic Inflammation with Pontine Perivascular...

MalaCards organs/tissues related to Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids:

42
Testes, Brain, Spinal Cord, Eye, Cerebellum, T Cells, B Cells

Publications for Chronic Lymphocytic Inflammation with Pontine Perivascular...

Articles related to Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids:

(show top 50) (show all 110)
# Title Authors Year
1
Recurrent Epstein-Barr Virus-positive (EBV+) Primary Central Nervous System Lymphoma (PCNSL) in a Patient with Clinical Features of Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids (CLIPPERS). ( 30880301 )
2019
2
Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) in limited cutaneous sclerosis: a rare disease combination. ( 30617191 )
2019
3
Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) associated with or without lymphoma: Comparison of clinical features and risk factors suggestive of underlying lymphomas. ( 31088767 )
2019
4
Isolated painful trigeminal neuropathy as an unusual presentation of chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids: A case report. ( 29863408 )
2019
5
Is chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) in children the same condition as in adults? ( 30146710 )
2019
6
Growing the phenotype of chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) in children. ( 30246371 )
2019
7
CLIPPERS: An Increasingly Recognized Chronic Inflammatory Central Nervous System Disorder. ( 30367853 )
2019
8
CLIPPERS Spectrum Disorder: A Rare Pediatric Neuroinflammatory Condition. ( 30873425 )
2019
9
A case of CLIPPERS syndrome responsive to tocilizumab. ( 30882019 )
2019
10
CLIPPERS and its mimics: evaluation of new criteria for the diagnosis of CLIPPERS. ( 31072955 )
2019
11
Diffuse white matter alteration in CLIPPERS: Advanced MRI findings from two cases. ( 31103957 )
2019
12
Switch from previous major depression comorbid with CLIPPERS to mania-like episode following glucocorticosteroid therapy: a case report. ( 30582117 )
2018
13
CLIPPERS mimickers: relapsing brainstem encephalitis associated with anti-MOG antibodies. ( 29356261 )
2018
14
Misdiagnosis: CNS Erdheim-Chester disease mimicking CLIPPERS. ( 28685649 )
2018
15
Occipital Headache in Chronic Lymphocytic Inflammation With Pontine Perivascular Enhancement Responsive to Steroids (CLIPPERS). ( 29193048 )
2018
16
Case 259: Primary Central Nervous System Lymphomatoid Granulomatosis Mimicking Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids (CLIPPERS). ( 30332362 )
2018
17
CLIPPERS with longitudinally extensive transverse myelitis: Role of T versus B cells. ( 29406923 )
2018
18
Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids with seizures and central pyrexia, in a patient requiring tracheal intubation and mechanical ventilation: A case report. ( 29796076 )
2018
19
CLIPPERS, a possible symptomatic lymphohistiocytic immune reaction. ( 29161338 )
2018
20
Reply: CLIPPERS, a possible symptomatic lymphohistiocytic immune reaction. ( 29161360 )
2018
21
Reply: A case of CLIPPERS challenging the new diagnostic criteria. ( 29244097 )
2018
22
A case of CLIPPERS challenging the new diagnostic criteria. ( 29253092 )
2018
23
CLIPPERS: Cutaneous manifestations. ( 29291480 )
2018
24
Effective treatment of CLIPPERS with long-term use of rituximab. ( 29511706 )
2018
25
Blood and virus detection on barber clippers. ( 29629677 )
2018
26
Omics-Based Approach Reveals Complement-Mediated Inflammation in Chronic Lymphocytic Inflammation With Pontine Perivascular Enhancement Responsive to Steroids (CLIPPERS). ( 29740431 )
2018
27
CLIPPERS syndrome responsive to Leflunomide: A case report. ( 30149302 )
2018
28
Two cases of CLIPPERS with increased number of perivascular CD20-positive B lymphocytes. ( 30202949 )
2018
29
Reply: Two cases of CLIPPERS with increased number of perivascular CD20-positive B lymphocytes. ( 30203037 )
2018
30
Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids (CLIPPERS) with Limbic Encephalitis. ( 28824066 )
2017
31
Comparison of neural histomorphology in tail tips from pigs docked using clippers or cautery iron. ( 27903311 )
2017
32
CLIPPERS and the need for long-term immunosuppression. ( 28110629 )
2017
33
Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS): A lymphocytic reactive response of the central nervous system? A case report. ( 28284348 )
2017
34
Therapeutic Approaches in CLIPPERS. ( 28386850 )
2017
35
Electroencephalographic responses of anaesthetized pigs (Sus scrofa) to tail docking using clippers or cautery iron performed at 2 or 20 days of age. ( 28412163 )
2017
36
CLIPPERS. ( 28726127 )
2017
37
Diagnostic criteria for chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS). ( 29050399 )
2017
38
Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS): A pediatric case report with six year follow-up. ( 29055484 )
2017
39
Clinical and radiological CLIPPERS features after complete remission of peripheral T-cell lymphoma, not otherwise specified. ( 27084205 )
2016
40
CLIPPERS with diffuse white matter and longitudinally extensive spinal cord involvement. ( 26581298 )
2016
41
IFN beta 1a as Glucocorticoids-Sparing Therapy in a Patient with CLIPPERS. ( 26813773 )
2016
42
Widespread inflammation in CLIPPERS syndrome indicated by autopsy and ultra-high-field 7T MRI. ( 27144217 )
2016
43
Reply to CLIPPERS features before, during and after lymphoma. ( 27180607 )
2016
44
CLIPPERS features before, during and after lymphoma. ( 27197600 )
2016
45
CLIPPERS with diffuse white matter and longitudinally extensive spinal cord involvement. ( 27272037 )
2016
46
Horizontal eyeball akinesia as an initial manifestation of CLIPPERS: Case report and review of literature. ( 27559963 )
2016
47
Poster 330 Rehabilitation of a Patient with Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids (CLIPPERS) Syndrome: A Case Report. ( 27673085 )
2016
48
Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) with intracranial Epstein-Barr virus infection: A Case Report. ( 27861371 )
2016
49
A Rare Cause of Dizziness and Gait Ataxia: CLIPPERS Syndrome. ( 30151443 )
2016
50
MRI evolution of CLIPPERS syndrome following herpes zoster infection. ( 25432545 )
2015

Variations for Chronic Lymphocytic Inflammation with Pontine Perivascular...

Expression for Chronic Lymphocytic Inflammation with Pontine Perivascular...

Search GEO for disease gene expression data for Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids.

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