CNKL
MCID: CHR680
MIFTS: 14

Chronic Lymphoproliferative Disorder of Natural Killer Cells (CNKL)

Categories: Blood diseases, Immune diseases, Rare diseases

Aliases & Classifications for Chronic Lymphoproliferative Disorder of Natural Killer Cells

MalaCards integrated aliases for Chronic Lymphoproliferative Disorder of Natural Killer Cells:

Name: Chronic Lymphoproliferative Disorder of Natural Killer Cells 58
Nk-Cell Lineage Granular Lymphocyte Proliferative Disorder 58
Chronic Lymphoproliferative Disorder of Nk-Cells 58
Chronic Nk-Cell Lymphocytosis 58
Chronic Nk Lymphocytosis 58
Clpd-Nk 58
Cnkl 58

Classifications:

Orphanet: 58  
Rare haematological diseases


External Ids:

Orphanet 58 ORPHA512017

Summaries for Chronic Lymphoproliferative Disorder of Natural Killer Cells

MalaCards based summary : Chronic Lymphoproliferative Disorder of Natural Killer Cells, also known as nk-cell lineage granular lymphocyte proliferative disorder, is related to chronic nk-cell lymphocytosis and lymphoproliferative syndrome. An important gene associated with Chronic Lymphoproliferative Disorder of Natural Killer Cells is STAT3 (Signal Transducer And Activator Of Transcription 3). Affiliated tissues include nk cells.

Related Diseases for Chronic Lymphoproliferative Disorder of Natural Killer Cells

Diseases related to Chronic Lymphoproliferative Disorder of Natural Killer Cells via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 20)
# Related Disease Score Top Affiliating Genes
1 chronic nk-cell lymphocytosis 11.6
2 lymphoproliferative syndrome 10.6
3 autoimmune disease 10.3
4 allergic disease 10.3
5 chronic active epstein-barr virus infection 10.3
6 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.2
7 exanthem 10.2
8 peripheral nervous system disease 10.2
9 neuropathy 10.2
10 anemia, autoimmune hemolytic 10.2
11 deficiency anemia 10.2
12 polyneuropathy 10.2
13 thrombocytopenia 10.2
14 demyelinating polyneuropathy 10.2
15 hemolytic anemia 10.2
16 aggressive nk-cell leukemia 10.1
17 t-cell large granular lymphocyte leukemia 10.0
18 neutropenia 10.0
19 leukemia 10.0
20 large granular lymphocyte leukemia 10.0

Graphical network of the top 20 diseases related to Chronic Lymphoproliferative Disorder of Natural Killer Cells:



Diseases related to Chronic Lymphoproliferative Disorder of Natural Killer Cells

Symptoms & Phenotypes for Chronic Lymphoproliferative Disorder of Natural Killer Cells

Drugs & Therapeutics for Chronic Lymphoproliferative Disorder of Natural Killer Cells

Search Clinical Trials , NIH Clinical Center for Chronic Lymphoproliferative Disorder of Natural Killer Cells

Genetic Tests for Chronic Lymphoproliferative Disorder of Natural Killer Cells

Anatomical Context for Chronic Lymphoproliferative Disorder of Natural Killer Cells

MalaCards organs/tissues related to Chronic Lymphoproliferative Disorder of Natural Killer Cells:

40
Nk Cells

Publications for Chronic Lymphoproliferative Disorder of Natural Killer Cells

Articles related to Chronic Lymphoproliferative Disorder of Natural Killer Cells:

(show all 12)
# Title Authors PMID Year
1
Pulmonary infiltration as the initial manifestation of chronic lymphoproliferative disorder of natural killer cells: a case report and literature review. 61
33740949 2021
2
Chronic Lymphoproliferative Disorder of Natural Killer Cells: A Rare Event. 61
33062476 2020
3
A high definition picture of somatic mutations in chronic lymphoproliferative disorder of natural killer cells. 61
32321919 2020
4
Lack of Viral Load Within Chronic Lymphoproliferative Disorder of Natural Killer Cells: What Is Outside the Leukemic Clone? 61
33585237 2020
5
STAT3 mutations in natural killer cells are associated with cytopenia in patients with chronic lymphoproliferative disorder of natural killer cells. 61
30859397 2019
6
A Stab in the Back: An Unusual Case of Cutaneous Neural Infiltration as a Manifestation of Chronic Lymphoproliferative Disorder of Natural Killer Cells. 61
30371512 2019
7
The analysis of clonal diversity and therapy responses using STAT3 mutations as a molecular marker in large granular lymphocytic leukemia. 61
25281507 2015
8
Chronic lymphoproliferative disorder of natural killer cells: a distinct entity with subtypes correlating with normal natural killer cell subsets. 61
20111066 2010
9
A possible mechanism of NK cell-lineage granular lymphocyte proliferative disorder (NK-GLPD) in a patient with chronic active Epstein-Barr virus infection (CAEBV) and severe hypersensitivity to mosquito bites (SHMB). 61
12211536 2002
10
[CD16+ CD56- indolent, NK cell-lineage granular lymphocyte proliferative disorder with autoimmune hemolytic anemia]. 61
10774253 2000
11
P-glycoprotein expression on normal and abnormally expanded natural killer cells and inhibition of P-glycoprotein function by cyclosporin A and its analogue, PSC833. 61
9885221 1999
12
[Characterization of peripheral blood natural killer (NK) cells in two patients with CD16+ CD56- NK cell-lineage granular lymphocyte-proliferative disorder]. 61
7536278 1995

Variations for Chronic Lymphoproliferative Disorder of Natural Killer Cells

Expression for Chronic Lymphoproliferative Disorder of Natural Killer Cells

Search GEO for disease gene expression data for Chronic Lymphoproliferative Disorder of Natural Killer Cells.

Pathways for Chronic Lymphoproliferative Disorder of Natural Killer Cells

GO Terms for Chronic Lymphoproliferative Disorder of Natural Killer Cells

Sources for Chronic Lymphoproliferative Disorder of Natural Killer Cells

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....